Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 1-21 | 1.8e-07 | 24.7 | In-house | 347-367 (515) | alignment | ||
Range on Protein: 1-21
Range on HMM: 347-367/515.0
QRNRVILDSPDQDYINASQMK
|||||||||||.|||||||||
qrnrvildspdhdyinasqmk
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 1-22 | 2.2e-06 | 21.8 | In-house | 57-82 (315) | alignment | ||
Range on Protein: 1-22
Range on HMM: 57-82/315.0
QRNRVIL----DSPDQDYINASQMKS
...||.| ||||.||||||..||
dsarvkleviddsPdsdyinasyiks
|
|||||||||
0050432 | (Phosphotyrosine protein) phosphatases II | 2-60 | 2.7e-14 | 48.7 | In-house | 82-190 (308) | alignment | ||
Range on Protein: 2-60
Range on HMM: 82-190/308.0
RNRVILdSPDQDYINASQMKSC------------------------------------------------AQYWPDA---DSAQFGSYSVATLSTSSDGD
..||.| ... |||||| .. . |||||. .| ..| ..| .||. ...|
hsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevldd
VTTRQMKVTR
.|.|....|
ytvrtleltn
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 2-60 | 1e-13 | 46.8 | In-house | 52-159 (273) | alignment | ||
Range on Protein: 2-60
Range on HMM: 52-159/273.0
RNRVILDSPDQDYINASQMKS----------------------------------------------CAQYWPDAD---SAQFGSYSVATLSTSSDGDVT
..||.|.... |||||| .. ||||||. | ..| ..| .||. ...|.|
hsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddyt
TRQMKVTR
.|....|.
vrtleltn
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 2-61 | 1.2e-13 | 46.7 | In-house | 63-172 (288) | alignment | ||
Range on Protein: 2-61
Range on HMM: 63-172/288.0
RNRVILDS----PDQDYINASQMKS----------------------------------------------CAQYWPDADSAQFGSYSVATLSTSSDGDV
..||.| . .. |||||| .. ||||||. .| ..| ..| .||. ...|.
hsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddy
TTRQMKVTRN
|.|...||..
tvrtlevtnl
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 2-60 | 1.4e-12 | 43.0 | In-house | 53-161 (297) | alignment | ||
Range on Protein: 2-60
Range on HMM: 53-161/297.0
RNRVILDSPDQDYINASQMKS----------------------------------------------CAQYWPDA--DSAQFGSYSVATLSTSS--DGDV
..||.||... |||||| .. ||||||. .| ..| ..| .||... ..|.
htRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddy
TTRQMKVTR
|.|...||
tlrtlevtd
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 2-61 | 2.7e-12 | 42.1 | In-house | 42-158 (284) | alignment | ||
Range on Protein: 2-61
Range on HMM: 42-158/284.0
RNRVILDS-----PDQDYINASQMKS---------------------------------------------------CAQYWPDAD-SAQFGSYSVATLS
..||.|.| .| |||||| .. ||||||. . . ..| ..| .||
hsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtlls
TSSDGDVTTRQMKVTRN
. ..|.|.| ...|..
eevkddytvrtleltnl
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 2-61 | 3.2e-12 | 41.8 | In-house | 57-166 (317) | alignment | ||
Range on Protein: 2-61
Range on HMM: 57-166/317.0
RNRVILDSPD----QDYINASQMKS----------------------------------------------CAQYWPDADSAQFGSYSVATLSTSSDGDV
..||.| ... |||||| .. ||||||. .. ..| ..| .||. ....
hsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagi
TTRQMKVTRN
| |...|. .
tlrtlevedl
|
|||||||||
0045450 | (Phosphotyrosine protein) phosphatases II | 2-61 | 3.1e-11 | 39.0 | In-house | 69-188 (307) | alignment | ||
Range on Protein: 2-61
Range on HMM: 69-188/307.0
RNRVILDS-----PDQDYINASQM------------------------------------------------------KSCAQYWPDADSA-QFGSYSVA
..||.| | .| |||||| . . ||||||| .. ..| . |
htRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvt
TLSTSSDGDVTTRQMKVTRN
.||.. ....| |...||..
llseehldgytvrtlevtdl
|
|||||||||
0043336 | (Phosphotyrosine protein) phosphatases II | 2-61 | 8e-11 | 37.4 | In-house | 59-167 (278) | alignment | ||
Range on Protein: 2-61
Range on HMM: 59-167/278.0
RNRVILDSPD----QDYINASQM----------------------------------------------KSCAQYWPdADSAQFGSYSVATLSTSSDGDV
..||.|.. . |||||| . . |||||| .| ..| ..| .|.. ...|.
hsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddy
TTRQMKVTRN
|.|...||..
tvrtlevtnl
|
|||||||||
0039614 | (Phosphotyrosine protein) phosphatases II | 2-61 | 9.2e-11 | 37.2 | In-house | 70-179 (297) | alignment | ||
Range on Protein: 2-61
Range on HMM: 70-179/297.0
RNRVILDS-----PDQDYINASQMKS----------------------------------------------CAQYWPDADSaQFGSYSVATLSTSSDGD
..||.| . .| |||||| .. ||||||. . ..| ..| .|.. ...
hsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldg
VTTRQMKVTRN
.|.|...||.|
ytvrtlevtnn
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 2-60 | 1.3e-10 | 36.6 | In-house | 23-131 (245) | alignment | ||
Range on Protein: 2-60
Range on HMM: 23-131/245.0
RNRVILDSPD----QDYINASQM----------------------------------------------KSCAQYWPDADSAQFGSYSVATLSTSSDGDV
..||.| ... |||||| . . ||||||. .| ..| ..| .||. ...|.
htrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddy
TTRQMKVTR
|.|...||.
tvrtlevtn
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 2-60 | 3.6e-10 | 35.4 | In-house | 25-133 (249) | alignment | ||
Range on Protein: 2-60
Range on HMM: 25-133/249.0
RNRVILDS----PDQDYINASQMKS----------------------------------------------CAQYWPDADSAQFGSYSVATLSTSSDGDV
..||.| . .. |||||| .. ||||||. .| ..| ..| .||. . .|.
hsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddy
TTRQMKVTR
|.|....|.
tvrtleltn
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 2-60 | 2.3e-09 | 32.6 | In-house | 47-143 (278) | alignment | ||
Range on Protein: 2-60
Range on HMM: 47-143/278.0
RNRVIldspdqDYINASQMK--------------------------------------------SCAQYWPDADSAQFGSYSVATLSTSSDGDVTTRQMK
..||. |||||| .. ||||||. .| ..| ..| .||.. .|.|.| ..
hsrVk......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtll
VTR
||
vtn
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 2-60 | 1.3e-08 | 30.2 | In-house | 24-125 (243) | alignment | ||
Range on Protein: 2-60
Range on HMM: 24-125/243.0
RNRVILdsPDQDYINAS-----------------------------------------------QMKSCAQYWPdaDSAQFGSYSVATLSTSSDGDVTTR
..||.| .. |||||. ... |||||| .. ..| ..| .||... .|.| |
hsrvkl..egsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygdftvtllseehlddytvr
QMKVTR
.....
tlllen
|
|||||||||
subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 16-62 | 3.6e-09 | 30.9 | In-house | 126-172 (290) | alignment | ||
Range on Protein: 16-62
Range on HMM: 126-172/290.0
NASQMKSCAQYWPDADSAQFGSYSVATLSTSSDGDVTTRQMKVTRNS
. .. . | |||||.|....| .|. |. .. . ..|...|. ..
ieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknkn
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 17-61 | 4.9e-06 | 20.4 | In-house | 120-164 (296) | alignment | ||
Range on Protein: 17-61
Range on HMM: 120-164/296.0
ASQMKSCAQYWPDADSAQFGSYSVATLSTSSDGDVTTRQMKVTRN
...| . .||| .|.| | .... . ....|..|.|..
fdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkk
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 18-60 | 2.2e-06 | 22.1 | In-house | 127-171 (325) | alignment | ||
Range on Protein: 18-60
Range on HMM: 127-171/325.0
SQMKSCAQYWPDA--DSAQFGSYSVATLSTSSDGDVTTRQMKVTR
. ..||.|||. .| .||. | . | |...| .
lgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkq
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 19-62 | 1e-07 | 26.4 | In-house | 129-172 (307) | alignment | ||
Range on Protein: 19-62
Range on HMM: 129-172/307.0
QMKSCAQYWPDADSAQFGSYSVATLSTSSDGDVTTRQMKVTRNS
. | ||.|||. | |.|. | . |... .| . |...|...
nrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkk
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 19-61 | 9.7e-07 | 23.2 | In-house | 127-171 (305) | alignment | ||
Range on Protein: 19-61
Range on HMM: 127-171/305.0
QMKSCAQYWPDADSA--QFGSYSVATLSTSSDGDVTTRQMKVTRN
. . | ||||.. . .||..|| |... | ..|..|.. .
gkdkCrqYWpesktekkefgefsvelksektasdyieRklkisie
|
|||||||||
subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 20-62 | 1.8e-09 | 32.2 | In-house | 130-172 (297) | alignment | ||
Range on Protein: 20-62
Range on HMM: 130-172/297.0
MKSCAQYWPDADSAQFGSYSVATLSTSSDGDVTTRQMKVTRNS
|.||.||.| ...||. || .||.|. |...||...
dkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgk
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 20-62 | 3e-08 | 28.2 | In-house | 90-132 (250) | alignment | ||
Range on Protein: 20-62
Range on HMM: 90-132/250.0
MKSCAQYWPDADSAQFGSYSVATLSTSSDGDVTTRQMKVTRNS
| . |||| . ..|. | ||. .|.|.|..|.....
ektyhqywPvekaekyGdvtvsllskeefadytkrklklskak
|
|||||||||
subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 20-61 | 5.7e-07 | 23.8 | In-house | 125-166 (287) | alignment | ||
Range on Protein: 20-61
Range on HMM: 125-166/287.0
MKSCAQYWPDADSAQFGSYSVATLSTSSDGDVTTRQMKVTRN
. | ||||. .| .| |... |. ... |...|...
eevcyqyWpeeksvvlGeyniellneevnagyierklevknk
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 20-60 | 2.2e-06 | 21.7 | In-house | 125-164 (314) | alignment | ||
Range on Protein: 20-60
Range on HMM: 125-164/314.0
MKSCAQYWPDADSAqFGSYSVATLSTSSDGDVTTRQMKVTR
| .|||. . .| | ..|. . .. .| ..|..
rvkClkyWPedtev.ygdikvelvetellaelvvrifrvek
|
|||||||||
DSPc_SM00195 | 20-61 | 6.8e-06 | 21.0 | In-house | 108-152 (263) | alignment | |||
Range on Protein: 20-61
Range on HMM: 108-152/263.0
MKSCAQYWPDA--DSAQFGSYSVATLSTSSDG-DVTTRQMKVTRN
. |..|||. .. .||..|| . .. .. ....|....| .
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltke
|
|||||||||
PTPc_SM00194 | 20-61 | 6.8e-06 | 21.0 | In-house | 108-152 (263) | alignment | |||
Range on Protein: 20-61
Range on HMM: 108-152/263.0
MKSCAQYWPDA--DSAQFGSYSVATLSTSSDG-DVTTRQMKVTRN
. |..|||. .. .||..|| . .. .. ....|....| .
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltke
|
|||||||||
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 21-62 | 9.9e-19 | 61.8 | In-house | 410-451 (515) | alignment | ||
Range on Protein: 21-62
Range on HMM: 410-451/515.0
KSCAQYWPDADSAQFGSYSVATLSTSSDGDVTTRQMKVTRNS
||||||||||.| |||||||.|||||||||.| ||..|||||
kscaqywpdansvqfgsysvstlstssdgdmtirqlqvtrns
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 21-62 | 2.8e-07 | 24.9 | In-house | 130-172 (288) | alignment | ||
Range on Protein: 21-62
Range on HMM: 130-172/288.0
KSCAQYWPDADS-AQFGSYSVATLSTSSDGDVTTRQMKVTRNS
. | .|||||| ..|| | ... .|...|.. . ..
tkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkk
|
|||||||||
subfamily_PTPN9_pd | Subfamily PTPN9 | 21-60 | 9.9e-07 | 23.1 | In-house | 125-166 (297) | alignment | ||
Range on Protein: 21-60
Range on HMM: 125-166/297.0
KSCAQYWP--DADSAQFGSYSVATLSTSSDGDVTTRQMKVTR
|.|||| . .||.||..||..... . | ..|......
lkcgqyWpleeessaefgdlsvsnveveeeedykvrvleikn
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 21-61 | 1.6e-06 | 22.1 | In-house | 131-171 (564) | alignment | ||
Range on Protein: 21-61
Range on HMM: 131-171/564.0
KSCAQYWPDADSAQFGSYSVATLSTSSDGDVTTRQMKVTRN
. |..|||. .....|.. | .. |.. |..|....
vkchkYWPekgtetygeltVtleeeeeladyeirtfklkkk
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 21-61 | 2e-06 | 22.1 | In-house | 129-169 (318) | alignment | ||
Range on Protein: 21-61
Range on HMM: 129-169/318.0
KSCAQYWPDADSAQFGSYSVATLSTSSDGDVTTRQMKVTRN
. ...|||. .| ..|. | .. . .| . |..||||.
akvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrt
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 21-61 | 7.6e-06 | 20.9 | Pfam-A | 82-126 (235) | alignment | ||
Range on Protein: 21-61
Range on HMM: 82-126/235.0
KSCAQYWP--DADSAQFGSYSVATL-STS-SDGDVTTRQMKVTRN
. |||||| . .| ..|...| . ... . ..|.|..... .
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkk
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 21-61 | 7.6e-06 | 20.9 | In-house | 82-126 (235) | alignment | ||
Range on Protein: 21-61
Range on HMM: 82-126/235.0
KSCAQYWP--DADSAQFGSYSVATL-STS-SDGDVTTRQMKVTRN
. |||||| . .| ..|...| . ... . ..|.|..... .
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkk
|
|||||||||
NTP_transf_2 | Nucleotidyltransferase domain | 21-51 | 8.9e-06 | 12.5 | Pfam-A | 6-36 (93) | alignment | ||
Range on Protein: 21-51
Range on HMM: 6-36/93.0
KSCAQYWPDADSAQFGSYSVATLSTSSDGDV
... .....|. . |||| || || |.
erlkelygvaevvlfGSyarGtllpgSDiDl
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 22-63 | 3.9e-16 | 53.8 | In-house | 128-170 (315) | alignment | ||
Range on Protein: 22-63
Range on HMM: 128-170/315.0
SCAQYWPD--ADSAQFGSYSVATLSTSSDGDVTTRQMkVTRNSN
.|.||||| |||..|||..|..||...|.| ..|.. |||.|.
kcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkse
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 22-62 | 2.5e-07 | 25.2 | In-house | 140-180 (298) | alignment | ||
Range on Protein: 22-62
Range on HMM: 140-180/298.0
SCAQYWPDADSAQFGSYSVATLSTSSDGDVTTRQMKVTRNS
. .|||| ....|. .| ||. . .|...|..||....
kyhkywPdegketygeitvsllskeefadlivrklkvskkk
|
|||||||||
subfamily_PTPN3_pd | Subfamily PTPN3 | 22-61 | 1.8e-06 | 22.1 | In-house | 125-165 (280) | alignment | ||
Range on Protein: 22-61
Range on HMM: 125-165/280.0
SCAQYWPDA-DSAQFGSYSVATLSTSSDGDVTTRQMKVTRN
| ||||. |. ..|..|| ..... . .|.. ....
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdk
|
|||||||||
subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 39-62 | 9.1e-06 | 19.3 | In-house | 251-274 (392) | alignment | ||
Range on Protein: 39-62
Range on HMM: 251-274/392.0
SVATLSTSSDGDVTTRQMKVTRNS
...|||||||||...|.|..|..
hlqdlstssdGdvrskqlkefrsl
|