Gene SpurPTP-sf1-15 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP092_AA protein Get Run
SpurP092_AA_0-221 phosphatase_domain Get Run
SpurP092_AA_234-492 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1-267 4.7e-97 320.9 In-house 61-327 (564) alignment 
Range on Protein: 1-267
Range on HMM: 61-327/564.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGeEMYFEDIVVTCEAEVHGI
|| ||.|  .  |. |||.|||.|....|...|||.|||  ..|.|||||||.....||.| |.|..||| ||.||||..| .  .....|| |.|..  
dhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeela

HDARRSLVL--HKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQR
.   |.. |  .|..|.|   .|||| |||.||| .   ||..|..|.... ... |..|||||||||||. |..|  ..|.|. . |||...|.|.|. 
dyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkq

RPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFADLRTKsDQDVTLTKLDQEFEIMNKVCHEPP
|. ||||.||| |||.|.||.|   .| .. ... .|.  |... ..| . |.|..||. ..   ....
RnamVqteeQYiFiheailealacgntevesenlkqhlqkLaev.eedtemtgleleFqrLatakeiel
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-285 1.5e-95 315.2 In-house 56-340 (515) alignment 
Range on Protein: 1-285
Range on HMM: 56-340/515.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPD-QGEEMYFEDIVVTCEAEVHG
| .||.|..| |.|||||.|||||.||  ...|||||||| .|. ||||.|.|..| ||.| |.| .  |||| |||||  |. . |  | |   .    
dsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleac

IHDARRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRR
    .| | . |....| .  |||| |||||||.. | ||..|.||  ...  . ||..|||||||||||||..|. . .||.|  ||.||||. .||.|
tggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkr

PQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFADLRTKSDQDvTLTKLDQEFEIMNKVCHEPPMDATNVGKLEENASKNRY
|..||| ||| ||..|.|| |   .|.||   | .|. || .  |     .|. .||. .. .| .||   |  |.  .|  ||||
pylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgr.grskmtkefqtlkslcpdppasqtrsgrtrdnhpknry
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-257 2.8e-87 287.5 In-house 57-313 (315) alignment 
Range on Protein: 1-257
Range on HMM: 57-313/315.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPD-QGEEMYFEDIVVTC-EAEVH
|.|||.|..| |.|.|||.|||||.|. ....|||||||. .|. ||||||.|..| ||.| |.. .  |||| .|||| ... . |  | |.  . |  
dsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslead

GiHDARRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQR
.     | ||. | || | .  |.|| ||||||....| ||..|.||  ... |  .||||||||||||||||..|. ....|.|  ||.||||. .|. 
t.dgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrak

RPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFADLRTKSDQDvTLTKLDQEFE
||..||| |.| ||.||.|| |  ..|.|.  .| .|. ||.| .|     .|. .|||
rpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgs.grskmtkefe
0051299 (Phosphotyrosine protein) phosphatases II 1-220 2e-82 272.2 In-house 62-286 (288) alignment 
Range on Protein: 1-220
Range on HMM: 62-286/288.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDqGEEMYFEDIVVTCEAEVHGI
|| ||.|  ......|||.|||||. . .....|| |||  ....|||||||...|..|.| |.||..|..||..|||. |. ....||.||.  |..  
dhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevld

HDARRSLVLH------KDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRA
.   | | .       .|.|.|   |||.| ||| ||| ... ||.|...|.... ... | .|||||||||||..||||  ... ...| ||....|. 
dytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkr

MRQRRPQMVQTPEQYEFIHDAMLEFL
.|..||.||||||||.|...|.||.|
lreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-257 2.2e-81 268.4 In-house 59-316 (318) alignment 
Range on Protein: 1-257
Range on HMM: 59-316/318.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYfEDIVVTCEAEVHGI
||.|| |. . ... |||.||.||. ......|||.|.|    | |||||||...  .|.| |.....||.|...|||..| . | ...||. . ||.  
dhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsy.gklvvelkeevels

HDARRSLVLHKD--EEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSR-DDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQ
.   |.. ....  ||.|    .|.| |||.||| ... || ....|..   . . .|..|||||||||||| ||.|  ..|.|. . ||.|..|. .|.
dyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlre

RRPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFADLRtKSDQDVTLTKLDQEFE
.|. |||| .|||||.|..||.|   || .  . . ..  .|| ..|...  |..| ||.
qrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr.eqdpesgttemdaefq
0046845 (Phosphotyrosine protein) phosphatases II 1-226 2.5e-81 268.5 In-house 41-280 (284) alignment 
Range on Protein: 1-226
Range on HMM: 41-280/284.0
DHARVILDLIGDD-PHSDYVNASYIQSF-----TKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVTCE
|| ||.|. ...| ..|||.||||.. .      .....|| |||  ....|||||||...|..|.| |.||..|..||..|||. || ....|. ||. 
dhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtll

AEVHGIHDARRSLVLHK---DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRD--DKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTG---FV
 | .  .  .| | | .   ..|.| . |||.| ||| ||| ... ||.|...|.....  ... | .|||||||||||..||||  ... ...|    |
seevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgv

DIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFLVGHDTM
|... |. .|..||.||||.|||.|...|.||.|  . |.
dvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0050432 (Phosphotyrosine protein) phosphatases II 1-223 3.8e-81 268.1 In-house 81-302 (308) alignment 
Range on Protein: 1-223
Range on HMM: 81-302/308.0
DHARVILdligdDPHSDYVNASYIQSF--TKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQ--GEEMYFEDIVVTCEAE
|| ||.|     |..|||.||||.. .   .....|| |||  ....|||||||. .|..|.| |.||..|..||..|||.   |. .......||.  |
dhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllse

VHGIHDARRSLVLHK--DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRddKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRA
 .  .  .| | | .  |.|.| . |||.| ||| ||| ... ||.|...|..|.  .. | .|||||||||||..||||  ... ...| ||.|. |. 
evlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkk

MRQRRPQMVQTPEQYEFIHDAMLEFLVGH
.|..||.||||||||.|...|.||.|  .
lReqRpgmvqtpeqylflyralleylklk
0040438 (Phosphotyrosine protein) phosphatases II 1-239 6.6e-81 267.3 In-house 56-295 (317) alignment 
Range on Protein: 1-239
Range on HMM: 56-295/317.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDqGEEMYFEDIVVTCEAEVHGI
|| ||.|  .| |..|||.||||.. . . ...|| |||   ...|||||||.  |..|.| |.|...|..||..|||. ||.....|..||.  |..  
dhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeela

HDARRSLVLH--KDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQR
.   | | .   .|.|.| . |||.| ||| ||| . . ||.|...|.....|...|.||||||||||||..||..  ... ...|.||... |. .|..
gitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreq

RPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFADL
||..|||||||.|..||.||.|  ..|..|  ... ..  |
Rpgavqtpeqyrflydalleylkrkltlepaselklkllkl
0036941 (Phosphotyrosine protein) phosphatases II 1-231 1.6e-78 259.3 In-house 52-288 (297) alignment 
Range on Protein: 1-231
Range on HMM: 52-288/297.0
DHARVILdligDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQ-GEEMYFEDIVVTCEAEVH-
|| ||.|    ||..|||.||||.. .  ....|| |||  ....|||||||.  |..|.| |.||..|..||..|||.  ||.....|..||.  . . 
dhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv

-GIHDARRSLVLHK--DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDD--KSTPLLVHCSAGVGRTGVVIALDNEMQRAK---QTGFVDIFN
   .  .| | . .  ..|.| . |||.| ||| ||| ... ||.||..|.. ..   ...| ||||||||||.|..||.|  .|. .    .| |||..
llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdile

FVRAMRQRRPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDR
.|. .|..||..|||.|||.|...|.||.|  ..|..| ..
avkklReqRpgavqtleqyrflyeallellkkkltkepllk
subfamily_PTPRB_pd Subfamily PTPRB 1-221 1.8e-78 258.6 In-house 64-286 (293) alignment 
Range on Protein: 1-221
Range on HMM: 64-286/293.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVTCEAEVHGI
||.|| |  . |...|||.||.||. .. .. .||.|||  ... |||||||.|....|.| |.||.|||.|||.|||.. |.... || ||  || .  
dhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeele

HDARRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSR--DDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQR
. . |.| ..|..| | . ..||| ||| ||| . . ||.|...|...   . ...|..|||||||||||. ||||. .|. ... .|||| .| ..|..
dwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelRee

RPQMVQTPEQYEFIHDAMLEFLV
| ..||| .|| |||...|..| 
RnllvqtekqYifihqcvldllr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-257 6.6e-78 256.8 In-house 62-315 (315) alignment 
Range on Protein: 1-257
Range on HMM: 62-315/315.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQgeEMYFEDIVVTCEAEVHGI
|..|| | |.  |||||||||..|. ..|.. |||.|||||.|. ||||.|..... .|.| ||||.. | |.||||||.  .. .  | ||   | .  
dksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnt

HDARRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRP
. . |.|    ....| .  .|.| ||| |||.    |. .|. |.| .... ....|||||||||||  |.||  ...|.    .|..||.. .|| | 
eytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnri

QMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFADLRTKSDqDVTLTKLDQEFE
.|||. |||.||.||.|| .|  || | .| .....  | . |  |   | |...||
kmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllapsp.dtgstllqeqfe
0047943 (Phosphotyrosine protein) phosphatases II 1-220 1e-76 253.3 In-house 51-272 (273) alignment 
Range on Protein: 1-220
Range on HMM: 51-272/273.0
DHARVILdligDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGE--EMYFEDIVVTCEAEVH
|| ||.|    .|..|||.||||.. . .....|| |||   ...|||||||.. |..|.| |.||..|..||..|||. |.  ....... ||.  | .
dhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet

GIHDARRSLVLHK--DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDD--KSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRA
  .   | | | .  ..|.|   |||.| ||| ||| ... ||.||..|.. .    ...| .|||||||||||..||||  ... . .| ||... |. 
kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkl

MRQRRPQMVQTPEQYEFIHDAMLEFL
.|..|| ||||||||.|...|.||.|
lrsqRpgmvqtpeqyrflyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-256 3.2e-76 251.4 In-house 61-318 (319) alignment 
Range on Protein: 1-256
Range on HMM: 61-318/319.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEdIVVTCEAEVHGI
|..||.|  . . . |||.|||.|... ... .|| |.|  . | |||||||..|. ...| |.||.|.|.|..||||..  | | . ..|| | | .  
drtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGr.livtleeeeele

HDARRSLVL-HKDEEV--RCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDD-KSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMR
.   | | | .| .||  | . ||..| |||..||..   || .......||.  .| |. |||||||||||  |.||  ..| |. | .|.|..|. .|
dyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlR

QRRPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFADLRTKsDQDVTLTKLDQEF
  |. |||.||||.||..|.||..   || |  . . . . .|. | . |   |.|..||
tqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaek.vadtgetgleref
0043336 (Phosphotyrosine protein) phosphatases II 1-219 1.6e-75 249.5 In-house 58-276 (278) alignment 
Range on Protein: 1-219
Range on HMM: 58-276/278.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPdqGEEMYFEDIVVTCEAEVHGI
|| ||.|.|.| |..|||.||||.  . . ...||.|||.  ...|||||||.  |.||.| |.||..|..|| .|||  |. ....|..||.  | |  
dhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehld

HDARRSLVLH--KDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQR
.  .| | ..  .| |.|   |.|.. ||| ||| ..| ||.|...|.. ..|...|.||||||||||||..|||.  ..... .|.||... |. .|..
dytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreq

RPQMVQTPEQYEFIHDAMLEF
||..||||.||.|...|.||.
Rpgavqtpsqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 1-220 5.1e-75 248.4 In-house 68-304 (307) alignment 
Range on Protein: 1-220
Range on HMM: 68-304/307.0
DHARVILDLIGDD-PHSDYVNASYI--------QSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVV
|| ||.|  .... ..|||.||||.        ... . ...|| |||   ...|||||.|.. |..|.| |.||..|..|| .|||| |||.......|
dhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftv

TCEAEVHGIHDARRSLVLH---KDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDD--KSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGF-
|.  | |  .  .| | ..   ...|.| . |||.|.||| ||| ... ||.||.||.. ...  |..| ||||||||||||..||..  ... ...|  
tllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtl

--VDIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFL
  ||... |. .|..||..||.||||.|...|.||.|
ldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-232 1.5e-74 245.8 In-house 64-296 (297) alignment 
Range on Protein: 1-232
Range on HMM: 64-296/297.0
DHARVILDLIGDDPHSDYVNASYIQSFTKenTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKiKCEKYWPDQGEEMyFEDIVVTCEAEVHGI
|  ||.|  ..||| |||||||..... .   .|..| |. ...||||.||....| ||.| ... .. | || .||.|.|    | |..|. ..  .  
dssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsere

HDARRSLVLHKDE--EVRCLDHFHFTRWPDKGVPR--NVSVLLRFIQEVNQSRDDKST-PLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAM
   .|.|.. |..    | .. ..|..|||| |.|  ..| || .|.||... ....  ||||||.||||||||....|. . .||..  ||||..|. .
GfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkkl

RQRRPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRF
|| ||..||| |||.|.. |.||.|. .|| |. . |
rqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-256 4e-74 244.3 In-house 58-271 (392) alignment 
Range on Protein: 1-256
Range on HMM: 58-271/392.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGkikcekywpdqgeemyfedivvtceaevhgi
| |||.|..| | |.|||.|||||.||  |..||||||||..|. ||||||.|..| ||.| |.| .                                 
dsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...............................

hdarrslvlhKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRP
          | ...|.   |||| ||||.||. .| ||.||.||.    . . ||..|||||||||||||..|. . .||.| .||.||||  .|..||
..........kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrp

QMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFADLRTKSDQDVTlTKLDQEF
 |||| ||| ||. |.|| |. ..|.||  .| .| .|| | || ||. .|  .||
ymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdvr.skqlkef
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-227 5.7e-74 244.0 In-house 69-297 (298) alignment 
Range on Protein: 1-227
Range on HMM: 69-297/298.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVTCEAEVHGI
|..||.|  . .| .|||.|||........|..||.|.| .....||||||......||.| |||....|.|..|||||.|.| | |  |   . |... 
dssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefad

HDARRSLVLHKD-EEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKS-TPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQR
   |.  | .|. |. | . ..||| |||||||.| . .| ....|..|. .   .|..|.|||||||.|  ||.|  ..|.|.   ||.|. |...|..
livrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkk

RPQMVQTPEQYEFIHDAMLEFLVGHDTMI
||..||| ||| ||..|.||.|   .. |
rpgavqteeqYvfiyeavlealdsfndei
0039614 (Phosphotyrosine protein) phosphatases II 1-224 6.3e-74 244.4 In-house 69-293 (297) alignment 
Range on Protein: 1-224
Range on HMM: 69-293/297.0
DHARVILDLIGD-DPHSDYVNASYIQSFTK-ENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKiKCEKYWPDQGEemYFEDIVVTCEAEVH
|| ||.|  ... |..|||.||||.. . .  ...||.|||.  ...|||||||.  |..|.| |.||..|. ||..|||. |.  ...|..||.  . |
dhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh

GIHDARRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDD--KSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMR
  .  .| | . ...|.| . ||..| ||| ||| ....||.|...|.. .    |..| ||||||||||||..||..  ... . .| ||... |. .|
ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelr

QRRPQMVQTPEQYEFIHDAMLEFLVGHD
..||..||||.||.|..||.||.|  ..
eqRpgavqtpsqyrflydallellkrkl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-219 6.4e-74 243.6 In-house 60-278 (288) alignment 
Range on Protein: 1-219
Range on HMM: 60-278/288.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVTCEAEVHGI
|. || |.   . . .||.|||||..  |...|||.|||.  .. |||..|......||.| |.||..|| |||.||||....  . .. ||   . .  
DekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskele

HDARRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRP
.   |.| |.|... . . ..... |||.|||..   || ... |... .... |..|||||||||||. ||||. ... ... ..|....|  .|..|.
dfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRa

QMVQTPEQYEFIHDAMLEF
..||| .|||||....|. 
llvqtlkqYefiyevllsl
subfamily_PTPN12_pd Subfamily PTPN12 1-221 1.4e-73 242.3 In-house 53-278 (290) alignment 
Range on Protein: 1-221
Range on HMM: 53-278/290.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMY-FEDIVVTCEAEVHG
|..|| |  | ....|||.||..|.  ... .|||.|||  . . |||||.|.|.|| ..|| ..|. ||.|||.|||..|||   |... ||.|.| . 
dksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekav

IHDA-RRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEM---QRAKQTGFVDIFNFVRAM
 .|   |.| .....| | .  ||.| |||.|||.... ||..|..|.. ......||.|||||||||||..||.|      .. | .  .|.|. |. .
dddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlel

RQRRPQMVQTPEQYEFIHDAMLEFLV
|..|. .||| ||||... |..|.. 
rkqraalvqtkeqyelvykavaelvq
subfamily_PTPRK_pd Subfamily PTPRK 1-256 3.2e-73 241.3 In-house 56-312 (314) alignment 
Range on Protein: 1-256
Range on HMM: 56-312/314.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEmyFEDIVVTCEAEVHGI
|..||.|  | .||.|||.||..| |... . .|. |||    ..||||.|....  .|.| |.||..|..|| ||||...|   ..|| |..       
drsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetella

HDARRSLVLHK----DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMR
    | . ..|     ||.| . .|.|..||| .|| .   ||.....|..|....  ...|||||| ||||. ||.|  .. ... | ||.|| |...|
elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlr

QRRPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFADLRtKSDQDVTLTKLDQEF
.|.. ||.| ||| ||.|..||  .  .| ||  .|   . .   . |..   ..| .||
srkvnmveteeqykfiydvileaclcgetaipvsefkalylesi.rldpqtnssqlkeef
DSPc_SM00195 1-220 3.4e-73 241.6 In-house 39-262 (263) alignment 
Range on Protein: 1-220
Range on HMM: 39-262/263.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQ-GEEMYFEDIVVTCEAEVHG
|| ||.|. . ....|||.||.||.  .|...||| |||  . ..|||||||...|..|.| |. ...||.||..|||.. |... |..| |..  . . 
dhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekk

I-HDARRSLVLHKDE--EVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMR
  .  .| | | |..  | | . ..... |||.||| . . .|.....|..|.. .|.|..|||||||||||.....|  ... ...  ||||. |...|
kdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelR

QRRPQMVQTPEQYEFIHDAMLEFL
. ||.|||| ||| ||..|.||..
kqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1-220 3.4e-73 241.6 In-house 39-262 (263) alignment 
Range on Protein: 1-220
Range on HMM: 39-262/263.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQ-GEEMYFEDIVVTCEAEVHG
|| ||.|. . ....|||.||.||.  .|...||| |||  . ..|||||||...|..|.| |. ...||.||..|||.. |... |..| |..  . . 
dhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekk

I-HDARRSLVLHKDE--EVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMR
  .  .| | | |..  | | . ..... |||.||| . . .|.....|..|.. .|.|..|||||||||||.....|  ... ...  ||||. |...|
kdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelR

QRRPQMVQTPEQYEFIHDAMLEFL
. ||.|||| ||| ||..|.||..
kqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRA_pd Subfamily PTPRA 1-242 4e-73 241.1 In-house 71-317 (330) alignment 
Range on Protein: 1-242
Range on HMM: 71-317/330.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYfEDIVVTCEAEVHGI
|..||||  .   ..|||.|||.|. . . ...||.|||   .. |||||.|...  ||.| |.| .. . ||..||||.|   |  .| |. | |.  .
dfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvty.Gnirvevedetvlv

HDARRSLVLH------KDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRA
. . | ....      .....| .  |||| ||| ||| .   .|.....|.. .. .. |. |||||||||||  |.||. ..| |  . ||.|.||. 
dytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkr

MRQRRPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFADLRTK
.|..||||||| ||||||. ..||. .  || .    . .|.  | .|
lrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynk
Y_phosphatase Protein-tyrosine phosphatase 1-218 6e-73 240.5 Pfam-A 14-235 (235) alignment 
Range on Protein: 1-218
Range on HMM: 14-235/235.0
DHARVILdlIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWP-DQGEEMYFEDIVVTCEAEV--
|. || |   |.. .|||.||.|..........||.|||   .|.||||||||..|..|.| |.|..||. ||..||| ...|.....|| |......  
dktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekeke

HGIHDARRSLVLHKDEEV---RCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRA
.  . . | | |.|..|    | . ..|.| |||.|||.... ||..|..|..|...||.|..|||||||||||...|||  ........ ||....|. 
dekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivke

MRQRRPQMVQTPEQYEFIHDAMLE
.|..||.|||. |||.|...|.||
lRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1-218 6e-73 240.5 In-house 14-235 (235) alignment 
Range on Protein: 1-218
Range on HMM: 14-235/235.0
DHARVILdlIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWP-DQGEEMYFEDIVVTCEAEV--
|. || |   |.. .|||.||.|..........||.|||   .|.||||||||..|..|.| |.|..||. ||..||| ...|.....|| |......  
dktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekeke

HGIHDARRSLVLHKDEEV---RCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRA
.  . . | | |.|..|    | . ..|.| |||.|||.... ||..|..|..|...||.|..|||||||||||...|||  ........ ||....|. 
dekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivke

MRQRRPQMVQTPEQYEFIHDAMLE
.|..||.|||. |||.|...|.||
lRkqRpgmvqsleqYiflykaile
0042113 (Phosphotyrosine protein) phosphatases II 1-220 2.8e-71 235.1 In-house 22-243 (245) alignment 
Range on Protein: 1-220
Range on HMM: 22-243/245.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDqGEEMYFEDIVVTCEAEVHGI
|| ||.|  .| |..|||.||||.  .   ...||.|||   ...|||||.|.  ..||.| |.....|..||..|||. ||.....|..||.  | |  
dhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehld

HDARRSLVLH--KDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRD-DKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQ
.  .| | ..  .| |.|   |.|.. ||| ||| ... ||.|...|.. .  |...|.||||||||||||..||..  ..... .. |.... |. .|.
dytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrs

RRPQMVQTPEQYEFIHDAMLEFL
.||..||||.||.|...|.||.|
qRpgavqtpsqyrflyeallell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-220 1.8e-70 232.2 In-house 54-276 (281) alignment 
Range on Protein: 1-220
Range on HMM: 54-276/281.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVTCEAEVHGI
|..|| .    .. ..||.||........|. |||.|||  .|...||.|||...|..|.| |. ...||.|| .||||. .|. . |..|. .|| .  
DatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeeka

HDARRSLVL-HKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVN-QSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRA-KQTGFVDIFNFVRAMRQ
. ..| . | ... | | . ....| |||.||| . . || | .||.  .. .. .||..||||||||||. ||||  .... ...  .|. . |. .|.
tyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrk

RRPQMVQTPEQYEFIHDAMLEFL
.|  ||||  ||||.. |.|. |
ernlmvqtvvqyefvykavldal
0040439 (Phosphotyrosine protein) phosphatases II 1-220 1.9e-70 232.6 In-house 24-246 (249) alignment 
Range on Protein: 1-220
Range on HMM: 24-246/249.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDqGEEMYFEDIVVTCEAEVHGI
|| ||.|  ... ..|||.|||||  .   ...|| |||   ...|||||.|.  ...|.|.|.|| .|..||..|||. |......|..||.  . .  
dhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkd

HDARRSLVLH--KDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDD--KSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMR
.  .| | |.  .| |.|   |...| ||| ||| ... ||.||..|.. ...  |..|.||||||||||||..||..  ... . .. ||... |. .|
dytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllr

QRRPQMVQTPEQYEFIHDAMLEFL
..||..||.||||.|...|.||.|
sqRpgavqnpeqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-222 1.1e-69 229.4 In-house 22-244 (250) alignment 
Range on Protein: 1-222
Range on HMM: 22-244/250.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIkCEKYWPDQGEEMYFEDIVVTCEAEVHGI
|..||.|     | .|||.|||...........||.||| ...| ||||||......||.| |||....|  ...||| .. | | .  |   . |... 
dssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllskeefad

HDARRSLVLHKD-EEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDD-KSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQR
   |.  . ..  .. | . ..||. |||||||..    | ....|..|..  ...|..|.|||||||.|  ||.|  ..|.|.   ||.|......|. 
ytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkd

RPQMVQTPEQYEFIHDAMLEFLVG
||..|.. ||| |.. ..|..|. 
rphavesleqyvfvyeiilkalds
subfamily_PTPRG_pd Subfamily PTPRG 1-227 1.2e-68 226.7 In-house 60-294 (563) alignment 
Range on Protein: 1-227
Range on HMM: 60-294/563.0
DHARVILDLIGDDPH-SDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDqGEEMYFEDIVVTCEAEVHG
|..|| |  . .  .  ||.||.||. . |.. .||.|||  . . |||||.|...|..|.| ||||..|. ||. |||   | . .. . || ..| . 
drsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevl

IHDARRSLVLHK-------D-EEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNF
.  . |.||...       . ....   ..|.|.|||.|||      | |..  .... ..  |..|||||||||||. |.||  ... .|   |..|.|
alytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgf

VRAMRQRRPQMVQTPEQYEFIHDAMLEFLVGHDTMI
.. .| .|. .||| ||| |.|||.|| . ...| .
lkhiraqRnflvqteEqYiflhdalleaiasketel
0045098 (Phosphotyrosine protein) phosphatases II 1-221 5e-67 221.5 In-house 46-273 (278) alignment 
Range on Protein: 1-221
Range on HMM: 46-273/278.0
DHARVIldligddphsDYVNASYIQSFtkENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDqGEEMYFEDIVVTCEAEVHGI
|| ||.          ||.|||||...   ...|| |||  . .||||||.|.  ...|.|.|.||..|..||..|||. |. ....|..||.. | .  
dhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevld

HDARRSLVLH------KDEEVRCLDHFHFTRWPDKGVPRNV--SVLLRFIQEVNQSRD-------------DKSTPLLVHCSAGVGRTGVVIALDNEMQR
.   | | ..      .| | | . |.|.. ||| ||| .   . .|........ ..             |...| ||||||||||||...|..  ...
dytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlel

AkqTGFVDIFNFVRAMRQRRPQ-MVQTPEQYEFIHDAMLEFLV
    | ||... |. .|..||. .||..|||.|.....||.| 
l..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Ptp69D_pd Subfamily Ptp69D 1-237 3.9e-66 218.3 In-house 61-303 (307) alignment 
Range on Protein: 1-237
Range on HMM: 61-303/307.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQgEEMYFEDIVVTCEAEVHGI
|. ||.|  |  . .|||.|||.|... .....||.|.|  . | |||||....||..|.| .|| .| . ||.||||.. .|. ..||.|..  | .  
DktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhs

HDARRSL-VLHKDEEV------RCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVR
. ..|.| | .|.||.      | .  .|.| |.|  ||.    ||..|..|..    . .|..|||||||||.|...|||  .|. |.   ||||..|.
dyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvk

AMRQRRPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFA
 .|..|. .||  |||.|.. |.|..    || .  | . ... 
dLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie
subfamily_PTPN6_pd Subfamily PTPN6 1-220 2.6e-65 215.4 In-house 67-297 (306) alignment 
Range on Protein: 1-220
Range on HMM: 67-297/306.0
DHARVILDlIGDDPHSDYVNASYIQ--SFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVTCEAEVH
||.||||    . | |||.||.||.  . .....|||.||   | ..||||||||.. . |.|.|. |..|| || .||||. |.  . .| ||. .| .
Dhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseks

GIHDARRSLVLH---KDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKS----TPLLVHCSAGVGRTGVVIALDNEMQRAKQTGF---VDI
  .   |.|...   |..| | . ..||. |||.|||.. ...| |...||. ... .     |..||||||.|||| .| .|  ..  ...|.   .||
ladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidi

FNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFL
 ..|. .|. | ..||| .|| |.. |. ...
qklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPN9_pd Subfamily PTPN9 1-224 1.6e-64 212.8 In-house 55-294 (297) alignment 
Range on Protein: 1-224
Range on HMM: 55-294/297.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWP-DQGEEMYFEDIVVTCEAEVHG
|..|| |  . .|..|||.||.... . .....|| |||    . |||||||..|| .|.|.| .|..|..|| .||| .... . | |. |.    .. 
detrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveee

IHDARRSLVLH--KDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRD-------------DKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTG
 .   |.|...  |.|| | . || |. ||| |||.. . || ....| . .               .  |..||||||.||||  |.||  ..| ...|
edykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg

FVDIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFLVGHD
 ||... |. .|..|  ..|||||||| . |.||. . ..
tvdvvetvkllrtqrafsiqtpeqyefcylavleyalelk
0037934 (Phosphotyrosine protein) phosphatases II 1-219 5.9e-63 208.0 In-house 23-241 (243) alignment 
Range on Protein: 1-219
Range on HMM: 23-241/243.0
DHARVILdligDDphSDYVNASYIQSFtkeNTYIASQGPNVTSIAD----FWRMVWQKEVETIIMATNLVDKGKIKCEKYWPdqgEEMYFEDIVVTCEAE
|| ||.|    ..  |||.||..|. .   ...||.|||   ...|    ||||.|.  ...|.| |.||..|..||..|||   .|....|..||.  |
dhsrvkl....eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gevtygdftvtllse

VHGIHDARRSLVLHK---DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQS--------RDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAkqtGf
 |. .   | |.|     |...|   |.|.. ||| ||| ... ||.|..||..          .|.. |.||||||||||||..||..  ...    | 
ehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.

VDIFNFVRAMRQRRPQ-MVQTPEQYEFIHDAMLEF
||... |. .|..||. .||||.||.|...|.||.
vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN3_pd Subfamily PTPN3 1-218 1.5e-62 206.1 In-house 54-273 (280) alignment 
Range on Protein: 1-218
Range on HMM: 54-273/280.0
DHARVILDligdDPHSDYVNASYI----QSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVTCEAE
|..||.|.    . ..||.||.|.    .| .  | |||.|||  .. .|||.|||......|.| |.||..|..|| .|||....|. . .. |.|| |
datrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkceke

VHGIHDARRSLVLHKDE--EVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRA
 .    . | |||.. |  | | . .. .. |||.||| . . .|.|...|.. |  |..|..||||||.|||||.|.|.  ..   ..  | . . || 
detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrt

MRQRRPQMVQTPEQYEFIHDAMLE
||..|  .|||..||.|. .|.|.
mrdqramlvqtasqykfvCeailk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-246 2.1e-62 206.3 In-house 74-317 (319) alignment 
Range on Protein: 1-246
Range on HMM: 74-317/319.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATnlvdkgKIKCEKYWPDQGEEMYFE-DIVVTCEAE--V
|...| |. .     |||.|||... . ... |||.|||   ..||||||.|. .. ||.. |      | || .||| .... . . .. |.   |   
dknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae

HGIHDARRSLVlHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVN--QSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAM
. . | . |    | ...| .  |||  |||.|||   | |.|... |.  .|. .. ....|||||||||||| |.||  ..| |.   ||..|||| .
yvvrdielsed.gkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdl

RQRRPQMVQTPEQYEFIHDAMLE-FLVGHDTMIPRDrFIEHFADLRTKSDQD
||.|...||   || ||. |.|| .|.||  .   | |  .. .| .||| |
rqqrntlvqdlvqykfiysalleehlfghsdvampd.fpayleelsnksdfd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-246 5.8e-62 204.8 In-house 38-281 (284) alignment 
Range on Protein: 1-246
Range on HMM: 38-281/284.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATnlvdkgKIKCEKYWPDQGEEMYFE-DIVVTC--EAEV
|...| |. .     |||.|||.|. . ... |||.|||   ..||||||.|. .. ||.. |      | || .||| .... . . .. |.   |.| 
dknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee

HGIHDARRSLVLhKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVN--QSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAM
. . | . |    | ...| .  |||  |||.|||   | |.|... |.  .|. .. ....|||||||||||| |.||  ..| |.   ||..|||| .
yvvrdielsedg.kekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdl

RQRRPQMVQTPEQYEFIHDAMLE-FLVGHDTMIPRDrFIEHFADLRTKSDQD
||.|...||   || ||. |.|| .|.||  .   | |  .. .| .||| |
rqqrntlvqdlvqykfiysalleehlfghsdvalpd.fpayleelsnksdfd
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-258 5.8e-61 201.4 In-house 61-325 (325) alignment 
Range on Protein: 1-258
Range on HMM: 61-325/325.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMV--WQkevETIIMATNLVDKGKIKCEKYWPDQ-GEEMYFEDIVVTCE-AE
|..||.|   .|||.|||.||||.... | ....|.| |. ..| |.||.|  |.    .... .| .|.|| .| .|||.. |.   |  . |    .|
dksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtie

VHGIHDaRRSLVL--HKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSR------DDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDI
    .   | | .   |. | |..  |..  |.| ||..  . |. ..| |..           |||.||||||||||||| |.|   ...  .   |||
eisdyv.hrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdi

FNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFADLRTKSDQDVTLtKLDQEFEI
|.||. .|. ||.||.| .|| .|..|. |...  .| .|   |  ... |. .      | ....||||
fgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqkl.niekefei
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1-218 2.7e-59 195.3 In-house 16-237 (237) alignment 
Range on Protein: 1-218
Range on HMM: 16-237/237.0
DHARVILDLIGDDphSDYVNASYIQSFTK-ENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVT-CEAEVH
||.||.|   | .  |||.||.|...|    ..|||.|||  .|  |||.||||.    |.| | |... ..|| ||||.  .   .  . |. .  |  
dhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeef

GIHdARRSLVLHK---DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQE-VNQSRD-DKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVR
  . . |||.| |    .||| .  ..|| |||.|||.. . |||| .. .|.|.   .|.| ..||||||||||... .|  ...||.   |||.|.| 
sdy.tvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvy

AMRQRRPQMVQTPEQYEFIHDAMLE
.. . || ..|| .|| |||...||
sieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-220 2.9e-58 192.0 In-house 59-283 (290) alignment 
Range on Protein: 1-220
Range on HMM: 59-283/290.0
DHARVILDLIGDD--PHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMyFEDIVVTCEAEVH
|  |..|  |...     .|.||.||. . ... ||| |||    ..|||...||..|  |.| || ...|| || .||||.. .. .. . ..   | .
ddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneet

GIHDARRSLVLHKDEE---VRCLDHFHFTRWPDKG-VPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRA
  .  .| | ......    . . ....| |...| |. . ..|| . . ... | .  |...||||..|||..| .|... ....|..| .|.|. .. 
lneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlks

MRQRRPQMVQTPEQYEFIHDAMLEFL
.|. .|..||| .||..|.. .|. |
qRiqkpgsvqtvqqyqgifqivltyl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1-218 1.4e-57 189.7 In-house 20-238 (239) alignment 
Range on Protein: 1-218
Range on HMM: 20-238/239.0
DHARVILDLIGDDPHSDYVNASYIQSFTK-ENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEeMYFEDIVVTCEAEVHG
||.||.|. . .||||||.||||.. .    ..|||.||   .|  |||||.||.    |.| | |..  | || .||||     | .  |   ..||  
dhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kycnlrvtlrktevfa

IHDArRSLVLHK--DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQ
 .   |..|. .  . | | . ..||| |||||||.  . .| . ... .     . | ..|||||||||| .. .|  ...||.   |||||.|.|.|.
dyii.rtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkaire

RRPQMVQTPEQYEFIHDAMLE
 ||.|||| ||| ||| |.||
drphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1-218 1.9e-57 189.2 In-house 21-239 (239) alignment 
Range on Protein: 1-218
Range on HMM: 21-239/239.0
DHARVILDLIGDDPHSDYVNASYIQSFTK-ENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEeMYFEDIVVTCEAEVHG
||.||.|. . .||||||.||||.. .    ..|||.||   .|  |||||.||.    |.| | |..  | || .||||     | .  |   ..||  
dhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kycnlrvtlrktevfa

IHDArRSLVLHK--DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQ
 .   |..|. .  . | | . ..||| |||||||.  . .| . ... .     . | ..|||||||||| .. .|  ...||.   |||||.|.|.|.
dyii.rtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkaire

RRPQMVQTPEQYEFIHDAMLE
 ||.|||| ||| ||| |.||
drphmvqtseqyvfihlavle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-237 1.8e-56 186.5 In-house 61-296 (439) alignment 
Range on Protein: 1-237
Range on HMM: 61-296/439.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKikcekYWPDQGeEMYFEDIVVTCEAEVHGI
||.||.|. |   ||| |.|| ||. . ... |||.|||.  .  ||||.|..| . ||.| ||||.  |     ||| .. |... ||.| .. ..   
dhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsda.evcygdiavrvdrnielp

HDARRSLVLHK----DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDK-STPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAM
. . | . . .     |  | . .||.. |||| || . | .| |.. .| . |..   |..||||||||||| .||||  ... |    |||   |. .
nyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvl

RQRRPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRFIEHFA
|..| ||||.  || ||..|.|| .|  |. .  |.|  .| 
rkqrkqmvqalcqyvfiynavledivyGdiavtidefkkefn
subfamily_PTPN23_pd Subfamily PTPN23 1-218 6.6e-56 184.2 In-house 56-278 (288) alignment 
Range on Protein: 1-218
Range on HMM: 56-278/288.0
DHARVILDligdDPHSDYVNASYIQSFTKE-NTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWP-DQGEEMYFEDIVVTCEAEVH
||.|| |.    . . ||.|||.... .    ..||.|.|  ....|||.||... ...|.| ..  ..|| |...||| |.|| . |.|. ||.. . .
DhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre

GIHDARRSLVL--HKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQ----SRDDKSTPLLVHCSAGVGRTGVVIALDNEMQR-AKQTGFVDIFNF
  .  .| | |  .. ..|. . | ..| ||. |||   ..||.|..||..     .    |||.||||||||||||.  .   ..   |. | .|| . 
tethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqv

VRAMRQRRPQMVQTPEQYEFIHDAMLE
|. .|. |  |||. ||..|  .|.||
vsrlreqRrfmvqekeqlkfsyeavle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-225 1.5e-54 180.0 In-house 60-283 (287) alignment 
Range on Protein: 1-225
Range on HMM: 60-283/287.0
DHARVILDligdDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEeMYFEDIVVTCEAEVHGI
|  ||.|     . | ||.||..|... ... .|....| .  . .||.......|..|.| ... .. . .| .|||..   ... .  ..   | .  
dnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevna

HDARRSLVLHK---DEEVRCLDHFHFTRWPDKG-VPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMR
.   | | ...   ... . .  ...| |...| |..  ..|| . . . . |    |...||||..|||... .| .  ....|. | .|.|. .. .|
gyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqr

QRRPQMVQTPEQYEFIHDAMLEFLVGHDT
...|..||| |||.|| |..||.|   .|
iqkpgsvqtveqykfindivleyldsfet
subfamily_CG7180_pd Subfamily CG7180 1-221 6.3e-53 174.3 In-house 55-291 (296) alignment 
Range on Protein: 1-221
Range on HMM: 55-291/296.0
DHARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKiKCEKYWPDQGEEMYFEDIVVTCEAEVHGI
|..||.|. .. . .|||.||.|..||.|.. ||  ..|   .. .|||.|...|...... |.  |  | .. .||| ...| | | .| . | .    
DynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyan

HDARRSLVLHK-----------DEEVRCLDHFHFTRWPD-KGVPRNVSVLLRFIQEVNQSRD-----DKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQT
   |   . .|           . |.| . .|..| |.  . ||   . |. ... |.. |.     ..  |..|..| |..|.|| .|.|  .. ....
lkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelveke

GFVDIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFLV
. ||.|..|. .|. |||.|.. |.| .| | .||...
eevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPRN_pd Subfamily PTPRN 1-217 5.4e-49 161.5 In-house 69-289 (297) alignment 
Range on Protein: 1-217
Range on HMM: 69-289/297.0
DHARVILDLIGDDPHSDYVNASYIQSF-TKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVTCEAEVHG
||.|| |.   .. .|||.||| |     .. .|||.|||  ...||||.|||.. |  |.. |.| ..|  .|..||||.|.|.|    |      .  
dhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwc

IHDARRSLVLH--KDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRA-KQTGFVDIFNFVRAMR
     ||. |   . .| | .  |||  ||..||| .   || | . ||.|   .|.|..||||.|.||||| |..|  ..|  |    .||   .  .|
ddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlr

QRRPQMVQTPEQYEFIHDAML
..||..|.| .|.||.  |. 
dqrpglvktkdqfefaltava
subfamily_PTPN1_pd Subfamily PTPN1 1-218 2.8e-48 159.1 In-house 45-269 (290) alignment 
Range on Protein: 1-218
Range on HMM: 45-269/290.0
DHARVILDligdDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPD--QGEEMYFEDIVVTCEAEVH
||.|..|.    . . ||.||| ..    .  || .||| .  .. ||.|||...  ...|  ..|.|..||| .|||   . .|. .||. .. .   .
dhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvklise

GIHD--ARRSLVLHK--DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSR--DDKSTPLLVHCSAGVGRTGVVIALDN---EMQRAKQTGFVDIF
 ...   .| | |..   .| | . |||.|.||| |||.  . .|.|...| .|    ..  | ..|||||.||.| .. .|    .... ...  ||| 
erksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdik

NFVRAMRQRRPQMVQTPEQYEFIHDAMLE
. . ..|. |  ..||..| .| . |.||
kvllelrkyrlGliqtadqlrfsylaile
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-219 1.9e-47 156.4 In-house 51-276 (287) alignment 
Range on Protein: 1-219
Range on HMM: 51-276/287.0
DHARVILDLIGDDpHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVT-CEAEVHG
|..||.|   |.   |||.|| |. |.|.....||.|||  ... ||||.|..... ..|. |  |.... || ||||..   |      |.  . ..  
ddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydike

IHDARRSL-VLHKDE-EVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEV----NQSRD-DKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFV
 . . |.| ... .  | | .  ...  ||||...     |.||. .|    . .|| ..  ||.||...|.||.|...|.   ..| ...| ||. . |
PeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavv

RAMRQRRPQMVQTPEQYEFIHDAMLEF
  .|..|  .||.. |. .. .|.  .
irlreyraalvqavvqlrllyealvty
subfamily_PTPN14_pd Subfamily PTPN14 1-220 2.1e-45 150.0 In-house 62-296 (300) alignment 
Range on Protein: 1-220
Range on HMM: 62-296/300.0
DHARVILDLIGDDpHSDYVNASYIQSF--TKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQG---EEMYFEDIVVTCEA
...|| |    .. ...|.||| |.    .|| .||..|||  . . |||.|||...|. |.| |.  ..|| |. ||.|...   ... |.   || . 
ednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkf

EVHGIHDARRSLVLHK--DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRD---------DKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTG
  .    . ..| |.    .| | . |. .| |||.|||..|.  | ...||.  |          ... |.|||||||||||||.|  |  ..  ..  
sedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehne

FVDIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFL
 .|| . .. .|..|  .|||  ||.|........|
eidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1-220 2.4e-42 139.6 In-house 69-283 (290) alignment 
Range on Protein: 1-220
Range on HMM: 69-283/290.0
DHARVILDligDDPHSDYVNASYIQSFtkENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQ-GEEMYFEDIVVTCEAEVH-
| .||||.   |  . ||| | |..    . ..| .||.   .. |.|||| |..| .|.|  .|...|| |||.|.|.. || . | .| |.|  | . 
dktrvilk...dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddk

GIHDARRSLVLHK--DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQsrddKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMR
  .  .. | . .  .     | |..   |||| |.     ||| .. . .     | |. ||||||.||||  .|..  .|   .   .|. . |||.|
daniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralr

QRRPQMVQTPEQYEFIHDAMLEFL
. | . ||   ||  . ...|.. 
nsrlnsvqvdiqylalveilldlG
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1-221 1.1e-40 134.5 In-house 54-278 (307) alignment 
Range on Protein: 1-221
Range on HMM: 54-278/307.0
DHARVILDLIGDdpHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWP-DQGEEMYFEDIVVTCEAEVHG
|..|... . |    |||. | |.   .| . .|..|||  ... .|| |. |..||..||  .... .|||||.||| ..|... | .   |   .  |
dkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlg

IHDA--------RRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQsrdDkSTPLLVHCSAGVGRTGVVIALDNEMQRAKQ-TGFVDIFN
..            .| .   .. |...|. .. |||.|||.     . ... |.    |   |..|||||||||.| ..|.   ...  .     |. .
akklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry...d.tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkk

FVRAMRQRRPQMVQTPEQYEFIHDAMLEFLV
.|. .|..|.  .||  || ..|  .||...
lveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1-219 1.9e-37 123.7 In-house 46-258 (267) alignment 
Range on Protein: 1-219
Range on HMM: 46-258/267.0
DHARVILDligdDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNlVDKGKIKceKYWPDQ-GEEMYFEDIVVTCEAEVHG
|..||||     .   .|.||||.... ..|..|. |.|   .|.||. .. ...| .|.. |. | ...|.  ..|| . |.   ..|..|    |   
ddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk.vftdnir..lfwPPkmgqakkyqdltvehslekee

IHDARRSLVL-HKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSrDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQR
      .| |  |.|  . .  ... .|  .   .     |  |   ||  .. . ||.|.||.||||.|  . .|  ..|||. | .|||.|.| .|..
ndyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknql.engnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsq

RPQMVQTPEQYEFIHDAMLEF
|. .|.| |.| .||. . |.
riglvdtkeryiyihellaey
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1-223 2.7e-36 119.9 In-house 61-290 (305) alignment 
Range on Protein: 1-223
Range on HMM: 61-290/305.0
DHARVILdlIGDDPHsDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPD-QGEEMYFED----IVVTCEA
|. || |   |  || .|. | |. . |. . .| .| |   . |||| | .|. ||.|.|  ||..||  || .|..  ..... ||.    |.| .|.
dnnrvkl..egpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfes

EVHGIH--DAR-----RSLVL-HKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEvnqSRDDKsTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVD
 |      ||.       ||.    |..|   |.|.  |||.|||     .| ....   .|  |  |. ||||||.|||| |. |.  ...  .   ..
svtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek...arpsk.gpivvhcsagigrtgsvvmleyildqllagqiie

I-FNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFLVGH
     .. .|..| . .|| .|| |.|. .|...  .
dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
0044763 (Phosphotyrosine protein) phosphatases II 1-217 2.8e-36 120.2 In-house 3-168 (178) alignment 
Range on Protein: 1-217
Range on HMM: 3-168/178.0
DHARVILDLIGDDPHSDYVNASYIQSFtkenTYIASQGPnvtsiADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEemyfedivvtceaevhgi
|. ||.|. . . . ||| |||.|  .     |..|..|     ||.......  . .|.. |. .  |..|| .|||.. .                  
drtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

hdarrslvlhkdeevrclDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRakqtGFvDIFNFVRAMRQRRP
                   ..... .|| |||   . .|.|.. ... .|.|  | ||||||||||.|...|..  ...    |. .... .. .|.|||
..................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp

qMVQTPEQYEFIHDAML
 .|..|.|......  |
.ivpnpgqlrqLyefel
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1-232 6.9e-34 112.2 In-house 56-283 (288) alignment 
Range on Protein: 1-232
Range on HMM: 56-283/288.0
DHARVILDligDDPHSdYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQ-GEEMYFEDIVVTCEAEVHG
| .|| |.   |||.  |..|  . |   ..  | .| |  . |  .|.|. ...|| |.| ..|..||| | ..|.| . ||.. .  .      .  .
ditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkrad

IHDARRSLVLHK--DEEVR-CLDHFHFTRWPDKGVPRNVSVLLRFIQEVnqsrDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMR
|.   .  .|.     | .  . . |.  |.|.||| |    ||... .     .   |..||.|||||||| .|     .. .. . |. | ...  .|
idklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklr

QRRPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRDRF
. | . .||  || ..|  .|| |. .     |. |
eerfkaiqtemqylyvhrcvleelllkkykvlredf
subfamily_ptpA1_pd Subfamily ptpA1 1-172 8.9e-29 95.4 In-house 60-248 (418) alignment 
Range on Protein: 1-172
Range on HMM: 60-248/418.0
DHARVILDLIGDDPHSDYVNASYIQSFtKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQ--GEEM--YF--EDIVVTCE
.|.|| |  | |   |||.|| ||.     . .|..|||   .|||||||||.. .  |.| .   .. .|||..|||.|  ||..  |   .... |  
nhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtys

AE-VHGIHDARRSLV-----LHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEV----NQ--SRDDKSTPLLVHCSAGVGRTGVVIA
 | |  |.|  | ..     |  . | | . ....  |||. .|     . .... .    ||     |.  |..||||||||||| . .
velveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1-72 7e-07 23.0 In-house 47-117 (332) alignment 
Range on Protein: 1-72
Range on HMM: 47-117/332.0
DHARVilDLIGDDPHSDYVNASYIQSFTKENTYIASQGPN-VTSIADFWRMVWQKEVETIIMATNLVDKGKIK
||.||  .|  .| . |. |||... ..|...|| .| |    .   ||||| ...   |..  .. .| | |
dhsrv..elapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-230 1.9e-73 242.3 In-house 60-293 (305) alignment 
Range on Protein: 2-230
Range on HMM: 60-293/305.0
HARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEE-MYFEDIVVTCEAEVHGI
. |.||    ....|||.||||.... ....||..|||  . .|||||....  |.||.| |.||. || ||..|||..  | . |....|. . | .  
ddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektas

HDARRSLVLHK---DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQS-RDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMR
    | | . .   |.| | . ....| |||.|||.  . ||..|..|... . || .||||||||||||||| ||.|  ..|.|. . ||.|. ....|
dyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlR

QRRPQMVQTPEQYEFIHDAMLEFLVGHDTMIPRD
..|..|||| .|| |.|||. | .   || |  .
skrmkmvqtldqYvflhdaldelitcgdtsiigs
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2-220 9.3e-66 216.7 In-house 42-268 (274) alignment 
Range on Protein: 2-220
Range on HMM: 42-268/274.0
HARVIL-DLIGDDPHSDYVNASYIQSFT-KENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEE---MYFEDIVVTCEAE
..||.|    ..|. |.|.|| ||. .  ....|.| ||| .. .||||||..|.||. |.| |.| .. . ||..|.||. .      ..|. .. |  
nsrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikveki

VHGIHDARRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKST---PLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVR
|.  .   |.|||.. |. | . |. .| |||. .|.... ||....||..||.....   | .||||||.||||. || .. ... .....||... | 
verndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivc

AMRQRRPQMVQTPEQYEFIHDAMLEFL
 .|. |  |||| ||||.|| |. ..|
nlrldrGGmvqtseqyelihralclyl
subfamily_PTPN13_pd Subfamily PTPN13 2-220 2.4e-53 176.2 In-house 51-269 (273) alignment 
Range on Protein: 2-220
Range on HMM: 51-269/273.0
HARVILDLIGDdphsdYVNASYIQSFTKENT--YIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEE-MYFED-IVVTCEAEV
..||.|.  |      |.|||.|.    ...  |||.|||  ....|||.|||....| |.| |. ..|||.||..|||.. .. .  .. . |. .  .
etrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvq

HGIHDARRSLVLHK--DEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDdKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAM
.    . |.| ...   .|.| . |..|. ||| |||..   ||.|..||.. .. ...|..||||||.||.|..|..|  ..  ..   .|. . || .
kldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrkl

RQRRPQMVQTPEQYEFIHDAMLEFL
|..|  .||| .|| |.. |.|| |
reqrqgvvqtkdqyifvykailevl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2-223 6.2e-31 102.1 In-house 66-293 (310) alignment 
Range on Protein: 2-223
Range on HMM: 66-293/310.0
HARVILDlIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVTCEAEVHG--
 .|| |  |    . ||. | |...    .|.| ||||   .| |||||..|.  |.|..  . ...|. ||  |||  |    .  | ||  .|     
tsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseef

-IHDARRSLV---LHKDEEVRCLDH-----FHFTRWPDKGVPRNVS--VLLRFIQEVnqsRddkSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDI
 | .   ..|   .  ||.   |..      ..  |||.||| .    |  |.. .|   |     | .||||||..|..||.||. .......   ||.
eicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqv...r...hgpcvvhcsagkdrlyvvvalklkidkldrglkvda

FNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFLVGH
 . .  ....| . .||. || .|.  .. |  |.
eevktellksraiciqtelqyliidrvriifarge
subfamily_egg_pd Subfamily egg 2-220 5.1e-23 76.2 In-house 54-270 (307) alignment 
Range on Protein: 2-220
Range on HMM: 54-270/307.0
HARVILDLIGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKgkIKCEKYWPDQGEEM-YF--EDIVVTC---EA
 .|| |.|       |.. | ...     |..| .| |   .  ||||||.|.||. |.| |  ..    .|| |||   ..   .    . ...   . 
ssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvds

EVHGIHDARRSLVLHKDEEVRCLDHFHFtrwpDKGVPRNVSVLLRFIQEVNQsrddKSTPLLVHCSAGVGRTGVVIALDNEMQ---RAkQTGFVDIFNFV
.   .    .  ..  |.| | |.|.      |     .|   || .. . .     |.| .|..  || ......|..  .    |   .    . . |
kadplfrvtklklvGgddeerflehwqg....dvnnssdvysplrvlrklrn....lskpvvvqdilGvskaatlvaieiallsllrG.pitkslvlrav

RAMRQRRPQMVQTPEQYEFIHDAMLEFL
  .|.||.  |... .| |..  .| |.
vflrlrrrlsvesvllylfvyrlvlfff
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 2-134 2.7e-06 20.4 In-house 41-157 (169) alignment 
Range on Protein: 2-134
Range on HMM: 41-157/169.0
HARVILDLIGDDPHSDYVNAsyiqsftkentyiasqgpnvtsiadfwRMVWQKEVETIIMATNLVDKGKIKCEKY----WPDQ-GEEMYFEDIVVTCE--
|.|| |. . .|  |||.||                           ||.|. .   |..  .  ||  .  ||      |     | | . . |  .  
htrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavilgewytdslyvrtdkv

-AEVHGIHD-ARRSLVLHKD-EEVR-CLDHFHFTRWPDKGVPRN
 | ..|..     |.|.|.  ..|   |. .|.. ||..|||..
hantsgveglfevsmvihsydddvteklsllhystwpqngvpqs
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 3-220 5e-66 217.5 In-house 35-264 (270) alignment 
Range on Protein: 3-220
Range on HMM: 35-264/270.0
ARVILDLIGDDPHSDYVNASYIQSFT-KENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEE---MYFEDIVVTCEAEVH
.||.|. . .|... |.|| |.. |. ....|||..||  |.. .||||.|...|..|.|.|.|..||. |||.||| . .|   . . .| |. ..|..
tRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseek

GIHDARRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVS------VLLRFIQEVNQSRD--DKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFN
     .. | |... | | | ||... |||.||||.         ||. ...| .|..  ||..||||||||||||||..||||  ..  ..|. ||. .
eegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvla

FVRAMRQRRPQMVQTPEQYEFIHDAMLEFL
 ....|. |...||.||||||.. |..|. 
iieelRkdRmalvqhpeqyeflykavveya
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 3-223 2.9e-35 116.3 In-house 52-272 (281) alignment 
Range on Protein: 3-223
Range on HMM: 52-272/281.0
ARVILDL-IGDDPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEE-MYFEDIVVTCEAEVHGI
.|| | . . .   .||. | ||.|   .  || .|||.  . ||||||.||..  .|.|  ....  . || .|.| .    . |. . |. |      
srvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnk

HDARRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNqsrdDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQ-TGFVDIFNFVRAMRQ-R
      | |  . | | . |. .  |||  ||    |.|. ....      .||| ..||||||||.| ..|..  .|  .    . || . |  .|   
slvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir....arstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtg

RPQMVQTPEQYEFIHDAMLEFLVGH
|   ||| .|| .|   .|.| | .
raasvqtlqqymliwkvlldfgvay
0049772 (Phosphotyrosine protein) phosphatases II 3-220 8.3e-35 116.4 In-house 60-280 (314) alignment 
Range on Protein: 3-220
Range on HMM: 60-280/314.0
ARVILDLIGDDPhSDYVNASYIQSFtkeNTYIASQGPNVTSIADF----------WRMV--WQKEVETIIM---------------------ATNLVDKG
 ||||.  . .  ||| ||||. .|   ...||.|||.   . ||          ||||  ..  | .| |                      ..|  .|
nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng

kikcekywpDQGEEMYFEDIVvtceaevhgihdarrsLVLHKDEE-VRCLDHFHFTRWPDKGVPrNVSVLLRFIQEVNQSrdDKSTPLLVHCSAGVGRTG
         ..  ....|..                  .|. .|   |   ... . .|| ..|   . ...|.. ...   || .|.||||.||.||||
.........neptaadlellk................eelydpelferlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtg

--VVIALdneMQRAKQTGFVDIFNFVRAMRQRRP--QMVQTPEQYEFIHDAMLEFL
  ||.|.   . .. .  . .....||..|  .|   .....||||||..|.||.|
tfvvaay...lmkllgvsleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_CG42327_pd Subfamily CG42327 3-148 8.8e-26 85.3 In-house 43-193 (319) alignment 
Range on Protein: 3-148
Range on HMM: 43-193/319.0
ARVILDLIGDDPHSDYVNASYIQSFTK-ENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQG---EEMYFEDIVVTCEAEVH
.||.|. ||||... |..|||.. . . .| |||.| .   | .||||.||..   .|. .|.| ..|  .| .|.| .    ..  . || ||      
trvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrev

GIHDARRSLVLHK--DEEVRCLDHFHFtRWPDKGVPRNVSVLLRFIQEVNQS
. . |  .|.|..  .|| | | |. . .|.. .|| . . |.  . ||..|
kdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 3-223 4.6e-25 83.3 In-house 33-257 (290) alignment 
Range on Protein: 3-223
Range on HMM: 33-257/290.0
ARVILDLIGDDPHSDYVNASYIQsFTKENTYIASQGPNVTS-------IADFWRMVWQKEVETIIMATNLVDKGKI----KCEKYWPDQ-GEEMYFEDIV
.||.|   |    .||. |.... . .    |..| |           | .|| |. | .|. ..|  .  .| .      |.|| |.. |||. |... 
trvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkglt

VTCEAEVHGIHDARRSLVLH-KDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNqsrdDKSTPLLVHCSAGVGRTGVVIALDNEMQRAK-QTGFVDI
| |   ..     .| ||..  |||   ..|  .  | .  |...  .||  || |.     . || .|||  |. |  .. |..  .|    ..| | .
vkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkl

FNFVRAMRQRRPQMVQTPEQYEFIHDAMLeflvgH
 . . |.|..| ......... |.  ...      
edvlkalrkqralaitsalelafvdagiv.....l
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 8-145 1.8e-26 87.7 In-house 51-193 (297) alignment 
Range on Protein: 8-145
Range on HMM: 51-193/297.0
DLIGDDPHSDYVNASYIQsFTKEN---TYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQ-GEEMYFEDIVVTCEAEVHGIHDA
 | .  . .||.|| |.  | .|.    || .|||  ... |||..|....| .|.| ..| . |. ||  |||.  .| .   |.||   ...   .| 
kllrviterdyinadyvv.fpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdr

R--RSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEV
     | |   .| | . |  |  |||.||| ..  | ||  .|
viltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 8-227 2.9e-25 83.6 In-house 61-283 (312) alignment 
Range on Protein: 8-227
Range on HMM: 61-283/312.0
DLIGDDPHsdYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVTC----EAEVHGIHDA
 | ||.    |. | ...  || . ....|||   ... ||...      .||. . .|. |  || ||  |    . .||  |      | |. |    
tlagdenf..yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskd

R---R--SLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQsrdDKsTPLLVHCSAGVGRTGVVIALDNEM---QRAKQTGFVDIFNFVRam
.   |   .|..   .   |.|. .. |||.|.|  .   ||..  |..   ||  |.. |||||||||| .. ..  .   .  ..    |.| ..|  
kithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk...dk.kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllr..

rQRRPQMVQTPEQYEFIHDAMLEFLVGHDTMI
 . | . |..  || .   ..||||  .  . 
.kdrarsvrvfpqyvyalrcvleflyskglyk
0046846 (Phosphotyrosine protein) phosphatases II 9-219 6.8e-43 141.8 In-house 5-172 (176) alignment 
Range on Protein: 9-219
Range on HMM: 5-172/176.0
LIGDDPHSDYVNASYIQSFtkenTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDqG-EEMYfedivvtceaevhgihdarrsl
|.|.|...||.||..| .      .|| ||| . ..|||..|...  ...... |..|..|..||  |||.   .. .                      
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi......................

vlhkdeevrcldHFHFTRWPDKGVPRNvSVLLRFIQEVNQSRDDKsTPLLVHCSAGVGRTGVVIALDnemqRAKQTGFVDIFNFVRAMRQRRP-QMVQTP
            ..... ||| |||   . ||........ ....  | |||||||.||||...|..      .   ...... .. .|..|| ..||||
............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

EQYEFIHDAMLEF
|||.|.....|..
eQyrflyefelll
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 12-221 4.4e-35 115.8 In-house 76-290 (305) alignment 
Range on Protein: 12-221
Range on HMM: 76-290/305.0
DDPHSDYVNASYIQS-FTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPD-QGEEMYFEDI-VVTCEAEVHGIH-DARRSL
. . |||. | |.   .  |. .|..|||   .| .|| || |. || |.|  . |. ||.|| .|||  ||| . .    ||   .  . .. ||   .
kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqi

----VLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRddksTPLLVHCSAGVGRTGVVIALDNEMQR-AKQTGFVDIFNFVRAMRQRRPQM
    . .  ..   . |...| |||.|||      | ..  .  |.     |..||||||.|||| ..|..  ... |..     . ..|.|.|..|   
tllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafs

VQTPEQYEFIHDAMLEFLV
.|.  || |||  ||....
iqndvqylfihrvmlnyfl
0041856 (Phosphotyrosine protein) phosphatases II 13-225 8.8e-46 151.1 In-house 16-176 (182) alignment 
Range on Protein: 13-225
Range on HMM: 16-176/182.0
DPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATnlvdkgkikCEKYWPdqgeemyfedivvtceaevhgihdarrslvlhkD
....||.||... .  . ...|| |||   ..|||.||...  . ||...|         .| |||                                 .
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.................................e

EEVRCLDHFHFTRWPDKGVPRnVSVLLRFIQEVNQsrddKSTPLLVHCSAGVGRTGVVIALDNEMQRakqtGfVDIFNFVRAMRQRRPQMVQTPEQYEFI
.. |   ..... ||| |||  .. ||.||.||..    .. | ||||||||||||...|..  ...    | |.... |. .|.|||.||.||.|| |.
llerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyffl

HDAMLEFLVGHDT
..|.||.| . .|
qlallellllkkt
0043147 (Phosphotyrosine protein) phosphatases II 13-213 6e-41 135.4 In-house 2-154 (172) alignment 
Range on Protein: 13-213
Range on HMM: 2-154/172.0
DPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLvdkgkikcekywpdqgeemyfedivvtceaevhgihdarrslVLHKD
|..|||.||||.    . . .|| |||    .||||||.... . .|...|.|                                          .. ..
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

EEVRCLDHFHFTRWPDKGVPrNVSVLLRFIQEVNQ-SRDDKSTPLLVHCSAGVGRTGVVIALDNEMqrakqtGFVDIFNFVRAMRQRRPQMVQTPEQYEF
 ..|   ..... ||| ||| . ..||.|.. ...    ... | ||||||||||||...|..  .        ..... |. .|..||..||.|.|| |
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IH
..
ly
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 13-61 7.4e-07 23.0 In-house 67-115 (347) alignment 
Range on Protein: 13-61
Range on HMM: 67-115/347.0
DPHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIM
|.   |.|||.|.    .. || .| |   .. |||.||    |  .. 
ddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 14-227 2e-52 172.9 In-house 57-273 (283) alignment 
Range on Protein: 14-227
Range on HMM: 57-273/283.0
PhsDYVNASYIQ---SFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYfEDIVVTCEAEVHGIHDARRSLVLH
.  ||.||..|    |  ... ||..|.|    . |||.||..... .|.| |.| .  .||| .||| .| | |  .  || . |.      .. |.|.
r..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy.Geftvtlrkettsnsfiikelllr

KD---EEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRPQMVQTPE
..   ..   | |. .  | . |    .  |..| . . . .. | .|..||||.|.|||.| ||.   .. |.    ||.|. |. ||..|. .||| .
vnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtld

QYEFIHDAMLEFLVGHDTMI
|| ..|...||  .  || |
qyklvhelvleqalcgdtqi
0051429 (Phosphotyrosine protein) phosphatases II 14-221 1.2e-50 168.0 In-house 2-226 (272) alignment 
Range on Protein: 14-221
Range on HMM: 2-226/272.0
PHSDYVNASYIQSFTK---ENTYIASQGPNVTSIADFWRMvWQKEVETIIMATNLVDKGKIKCEKYWP-----------DQGEEMYFEDIVVTCEAEVHG
| |.|.||...  ...   ......|.||   ..|||||. ..  . ||.. .... .|. ||..|||           |  ... . ...||.  |.. 
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

IHDARRSLVLH---KDEEVRCLDHFHFTRWPDKGVPRNVsvLLRFIQEVNQsrddkSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVD--------I
 .   | |.|.   . .|.| . |.|.|.||| |||..   ||........     . |.|||||||..|||.|.||.  ...   .  ||        .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFLV
...|. .|..||..|||.|||.|...|.||.| 
eeaveelraqrpgavqteeqylflyeallellr
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 14-225 1e-47 157.3 In-house 68-298 (301) alignment 
Range on Protein: 14-225
Range on HMM: 68-298/301.0
PHSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPD-QGEEMYFEDIVVTCEAEV-----------HGIH
 . .|.|||||....... .||.|||    ..||||..||. . .|.| ||| .. | |||.|||. . |. .|  . ||   |              |.
cqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiq

------DARRSLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQ-SRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRA
         |..  ..| . . .  .. | ||. || |.    |. |..| .  .     |..||||..|.|.|| ....  .  .|  | ||.|. ..|
dgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtka

MRQRRPQMVQTPEQYEFIHDAMLEFLVGHDT
.|. .| .|.| ||| .|.|.. ..|  ..|
vrrskpgaVtTLeqytsiydvidmylqlnst
0051082 (Phosphotyrosine protein) phosphatases II 14-217 3e-36 119.6 In-house 1-150 (151) alignment 
Range on Protein: 14-217
Range on HMM: 1-150/151.0
PHSDYVNASYIQSFtkentYIASQGPnvtsIADFWRMVWQKEVETIIMATNLVDKGkiKCEKYWPDQGeemyfedivvtceaevhgihdarrslvlhkde
|.||| |.||. ..     ...|.||     |||......  . ||.. ....  |  .| .|.|..|                                
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

evRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQsrdDKSTPLLVHCSAGVGRTGVVIALDNEMQRakqtgfVDIFNFVRAMRQRRPQMVQTPEQYEFIH
  . . |.... ||| |.| .   .|.|......   .|. |.|||||||.||||...||.  ...      |...  .. .|..|| .||...|. |..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DAML
 |.|
fall
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 14-225 2.4e-31 103.8 In-house 57-275 (285) alignment 
Range on Protein: 14-225
Range on HMM: 57-275/285.0
PHSDYVNASYIQSFTKE-NTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQ-GEEMYFEDIVV---TCEAEV-HG-IHDARrS
   ||. ||...   |. .|||..|||   ...|||.|..|...  ..|   |.. |  ||  |.|.. || . |    .    |. |   | | .|  .
hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnal.t

LVLHKD--EEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSrDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRPQMVQ
..  .|   |   ..| .   |||.  | .   .. . . |..  . | .|. ||||||||||  .. .|    |  .   ..... || ||  | | ||
vintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavq

TPEQYEFIHDAMLEFLVGHDT
.  |. |..  ..|...|   
shmqflflyvvlmeyfigegv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 15-221 1.2e-20 68.2 In-house 74-286 (302) alignment 
Range on Protein: 15-221
Range on HMM: 74-286/302.0
HSDYVNASYIQSFTKENTYIASQGPNVTSI---ADFWRMVWQKEVETIIMATNLVDKGKiKCEKYWP-DQGEEMYFEDIVVTCEAeVHGIHDARRSL---
  .||||| ..    ... | .| |.|.|    ..|||||.|... .. ..    .  |   ....|  .|.  ..... |     |   ....  .   
pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviE

VLHKDE-EVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRPQMVQTP
|| ..  .       ..| |..| || ... | . ...| ..  . . ....    |.|| |....|   ... ..   . | . |...|. ||..|.. 
vlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl

EQYEFIHDAMLEFLV
.|| ... |.| .. 
kQyvslyialllyik
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 15-223 1.7e-10 35.0 In-house 68-282 (303) alignment 
Range on Protein: 15-223
Range on HMM: 68-282/303.0
HSDYVNASYIQSFTKENtYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGEEMYFEDIVVT-CEAEVHGIHDARRSLVLH-KD
 | |. |||..  .. .  | .| |   . ||||.|. .. |  ...     .  |.  .  .| . . . ||. ..   |     . |     ||   .
dssyihasyleldsskk.ailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsn

EEVRCL-DHFHFTRWPDKGVPRNVS-VLLRFIQEVNQ--SRDDKSTPLLVHCSAGVGRTGVVIALDN-EMQRAKQTGFVDIFNFVRAMRQRRPQMVQTPE
 . ...    |.  || . .| . |  ... | ...    .  .||| .    .|.||.|    ..   .   ..   .|. . .  .|. | . ||   
gdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnls

QYEFIHDAMLEFLVGH
|. ...  . | ... 
qfsvvytllaehvldn
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 15-131 3.7e-08 27.7 In-house 12-126 (130) alignment 
Range on Protein: 15-131
Range on HMM: 12-126/130.0
HSDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKgkikcEKYWPDQGE-EMYFEDIVVTCeAEVHGIHDARRSLVLHKDE
  .|.|||..    . . |. .| |   .  |||.|. .. |. ...   . ..     ..||||    | | |||.||  .. .. .  . | .  ...
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtl.tdrdefknikasnleiesd

E---VRCLDHFHFTRWPDKGV
     ..|  |. . ||  | 
lneshqaltmfqisnwpsdgt
0036282 (Phosphotyrosine protein) phosphatases II 16-214 1.4e-46 153.6 In-house 2-164 (174) alignment 
Range on Protein: 16-214
Range on HMM: 2-164/174.0
SDYVNASYIQSFTKENTYIASQGPNVtsiadFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDqgeemyfedivvtceaevhgihdarrslvlHKDEEV
||| |||..  .   . .||.|||       ||.|...  ..|..| .... .|. ||  |||.                              ... ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

RCLDHFHFTRWPDKGVPRNVSvLLRFIQEVNQSRDD-KSTPLLVHCSAGVGRTGVVIALDNEMQRAKqTGFVDIFNFVRAMRQRRPQMVQTPEQYEFIHD
|   ..... ||| |||     ||.|...|.. . . .. |.||||||||||||...|..  ... . ...||....||..|. ||.|||||.||.|...
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 16-81 3.9e-14 47.1 In-house 83-154 (350) alignment 
Range on Protein: 16-81
Range on HMM: 83-154/350.0
SDYVNASYIQSF----TKEN--TYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQG
.||.||.|..        .    ||| |.|    . ||.... . .|. |.. |..|. .  ||..||.. .
nDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 16-134 2.5e-11 37.6 In-house 122-238 (244) alignment 
Range on Protein: 16-134
Range on HMM: 122-238/244.0
SDYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKgkikcEKYWPDQG-EEMYFEDIVVTC--EAEVHGIHDARRSLVLHKD
  |.|||..  . .   || .| |   .  |||.|. .. |. ...   . ..     ..||||    | | ||| ||     | . |. .   .    .
ntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmn

EEVRCLDHFHFTRWPDKGVPRN
|  ..|  |  . ||  |   |
eshqaltmfqisnwpsdgttpn
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 16-79 3.1e-09 30.6 In-house 90-155 (349) alignment 
Range on Protein: 16-79
Range on HMM: 90-155/349.0
SDYVNASYIQ--SFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPD
 ||.|| |..   .. |. ||| | |  ... ||....  ..|. ..  ..  ...  ||..|| .
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_eak_pd Subfamily eak 17-134 1.5e-14 48.1 In-house 79-197 (332) alignment 
Range on Protein: 17-134
Range on HMM: 79-197/332.0
DYVNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQG-EEMYFEDIVVTCEAEVHGIHDARRSLVLHKDEEV
 |.||| ..     . || .  .. . .  ||.|| ..   .|..  . |...  | .||.||.. ||. |  . |..   |.      | |.|.| .| 
GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnet

RCLDHFHFTRWPDKGVPRN
  . |...  | .  .|. 
hrvlhykvfGwtettlpky
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 19-211 1e-24 81.9 In-house 78-272 (301) alignment 
Range on Protein: 19-211
Range on HMM: 78-272/301.0
VNASYIQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQ-GEEMYFEDIVVTCEAEVHGI--HDARRSLVLH---KD
. | .|..  . . .||.|||   .  ||| |. | .||.|.| .. |.| . |||.| | . .|..  .   .. . . . .  .  .|.| ..   ..
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

EEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDdkstPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRPQMVQTPEQYEF
 . | . |. ...|.|.|||.    |  ... | .|..    |..||||||.||.   |. .   .. .    ... . .. .|..| . ||| .|  .
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 23-220 1e-06 21.6 In-house 107-309 (346) alignment 
Range on Protein: 23-220
Range on HMM: 107-309/346.0
YIQSFTKENTYIASQGPNV---TSIADFWRMVWQKEVETIIMATNlVDKGKIKCEKYWPD-QGEEMYFEDIVV-TCEAEVHGIHDARRSLVLHK--DEEV
|.  |  |.  | .| |..   . . ||| |..|.... . .     || |      . | .|   |   ...    |.| |        || .   . |
yfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvp.ddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsv

RCLDHFHfTRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRPQMVQTPEQYEFIHDA
 |  | | . |     | .   ....| .    .. ... . |    | ||.   |     ...  .    .|.. .....|.||  |..  ||  |.  
icqvhhh.apwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai

MLEFL
.....
vfdyi
0049260 (Phosphotyrosine protein) phosphatases II 24-214 7.6e-40 131.4 In-house 2-144 (152) alignment 
Range on Protein: 24-214
Range on HMM: 2-144/152.0
IQSFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWpdqgeemyfedivvtceaevhgihdarrslvlhkdeevrcldHFHF
|. . . . .|| |||   ..||||||...  . ||.| |.|...||.|||.|.                                          ....
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylh

TRWPDKGVPRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMqrakqtGFVDIFNFVRAMRQRRPQMVQTPEQYEFIHD
. ||| ||| .  .|| ... ... . ||. | ||||||||||||...|..  .        |.....|. .|..||..|..|.|..|...
lpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 26-94 4e-10 33.6 In-house 231-296 (440) alignment 
Range on Protein: 26-94
Range on HMM: 231-296/440.0
SFTKENTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKgkiKCEKYWPDQGEEMYFEDIVVTCE
 ..| |..||.| |  ... ||||.| . .. ||||  .| ||    |  ||| .   . |  . |   
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghk
subfamily_hpo-7_pd Subfamily hpo-7 30-222 1.5e-19 65.0 In-house 37-229 (263) alignment 
Range on Protein: 30-222
Range on HMM: 37-229/263.0
ENTYIAsqgpNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPD-QGEEMYFEDIVVTCEAEVHGIHDARRSLVL--HKDEEVRCLDHFHFTRW
 |.|.      |  |. |.... |.. |...| ..  ..|. ||..|.|  . | . .... |..   .. .    . |.    .  ... . |. .. |
knlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgW

PDKGVPRNVSVLLRFIQEVNQSRddkstPLLVHCSAGVGRTGVVIALDNEMQ------RAKQTGFVDIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFL
..|  |..    |. .. . .|.     .| ||||.|.||.      .   |      .  .|. .|  .... .|..|.. ..|| |  |    .|.|.
iekndpelareilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

VG
. 
ln
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 31-213 1.4e-23 78.2 In-house 5-197 (199) alignment 
Range on Protein: 31-213
Range on HMM: 5-197/199.0
NTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGE-EMYFEDIVVTCEAEVHGIHDARRSLVLHKD----EEVRCLDHFHFTR
  |||.| |   ..||||.|||.     |.|  .   . .     |||        .  . ||... .     .  .|.| ..       | . |. || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPrNVSVLLRFI---QEVNQS-RDDKSTPLLVHCSAGVGRTGVVIALDNEMQR--AKQTGFVDIFNFVRAMRQRRPQMVQTPEQYEFIH
| .|  | ||.... |.   .|| .   ..| .|..|||| | | ||| .|||  ..     .|  ||.|.  . .|| |  .. . ..|.||.
wkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 31-213 1.4e-23 78.1 In-house 4-196 (198) alignment 
Range on Protein: 31-213
Range on HMM: 4-196/198.0
NTYIASQGPNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQGE-EMYFEDIVVTCEAEVHGIHDARRSLVLHKD----EEVRCLDHFHFTR
  |||.| |   ..||||.|||.     |.|  .   . .     |||        .  . ||... .     .  .|.| ..       | . |. || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPrNVSVLLRFI---QEVNQS-RDDKSTPLLVHCSAGVGRTGVVIALDNEMQR--AKQTGFVDIFNFVRAMRQRRPQMVQTPEQYEFIH
| .|  | ||.... |.   .|| .   ..| .|..|||| | | ||| .|||  ..     .|  ||.|.  . .|| |  .. . ..|.||.
wkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 35-240 4.7e-21 70.0 In-house 39-235 (255) alignment 
Range on Protein: 35-240
Range on HMM: 39-235/255.0
AsqgpnvtSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPD-QGEEMYFEDIVVTCEAEVHGIHDARRS--LVLHKDEEVRCLDHFHFTRWPDKGV
        ... |.... |.. |...| ... ..|. ||..|.|  . | . ..|. ||.   .  .    .   . | .  . . . |.... |..|  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PRNVSVLLRFIQEVNQSRddkstPLLVHCSAGVGRTGVVIALDNEMQ------RAKQTGFVDIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFLvghdt
|..   .|  .. | .|.     ...||||.|.||.   .  .   |      .  .|. .|  .... .|..|.. ..|| |  |    .|...     
Pelareilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.....

mIPRDRFIEHFADLR
  |.. . ... ..|
.fpkgeleakyqeir
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 39-212 6.4e-17 55.9 In-house 99-280 (302) alignment 
Range on Protein: 39-212
Range on HMM: 99-280/302.0
PNVTSIADFWRMVWQKEVETIIMATNLVDKGKIKCEKYWPDQ-GEEMYFEDIVVT---CEAEVHGIHDARRSLVL--------HKDEEVRCLDHFHFTRW
|   ..  .| .. | .|  ..  ...|.... || .|. |. |.|. |    |.    . ...   | .   .         .|..  . .| ..|. |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDKGVPRNVSVLLRFIQEVNQSRddksTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRPQMVQTPEQYEFI
||.| |..    |  ..  .  .    . .|||||||||||| ..|.   .|  ..    |. . |  .|| |   ||. .|  ..
pdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_MTMR3_pd Subfamily MTMR3 89-174 8e-07 21.2 In-house 207-290 (442) alignment 
Range on Protein: 89-174
Range on HMM: 207-290/442.0
IVVTCEAEVHGIHD---ARRSLVLHKDEEVRCLDHFHFTRWPdkgvpRNVSVLLRFIQEVNQSRDDKSTPLLVHCSAGVGRTGVVIALD
.|    | .|..     . |.|. .. .| . | ... |.|      .|.||||.   .| .. | .. |.||||| |  ||  ..|| 
vvflglanihavrksfnslrallsqspdesnwlsalektkWl.....qnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivala
0048076 (Phosphotyrosine protein) phosphatases II 106-218 2.6e-26 87.4 In-house 35-141 (145) alignment 
Range on Protein: 106-218
Range on HMM: 35-141/145.0
SLVLHKDEEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKsTPLLVHCSAGVGRTGVVIALDnemqRAKQTGfVDIFNFVRAMRQRRPQMVQT
.|   .. ..|   ..... ||| |||   . ||.|.. ... ....  | ||||||||||||...|..      .. | |.... .. .|..||..|..
nltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqrpgavpn

PEQYEFIHDAMLE
|.|..|.... ||
pgqlrflyefele
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 113-261 1.1e-38 127.8 In-house 86-234 (440) alignment 
Range on Protein: 113-261
Range on HMM: 86-234/440.0
EEVRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDK-STPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRPQMVQTPEQYEF
 | |.| ..|.  |||||||. .. .|..||.||.|..   . |||||||||.|||||.||.|. .. ||..  .|||.|. .||. ||||||||||| |
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHDAMLEFLVGHDTMIPRDRFIEHFADLRTKsDQDVTLTKLDQEFEIMNK
.|.|.|| |.  ||.|  |   |.  ...   .  .  . |.||||   |
vheavlegllcgdtliledditerveqiqwp.nphtdksplqqefegysk
0048179 (Phosphotyrosine protein) phosphatases II 115-214 4.7e-25 83.4 In-house 46-139 (144) alignment 
Range on Protein: 115-214
Range on HMM: 46-139/144.0
VRCLDHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDdKSTPLLVHCSAGVGRTGVVIALDnemqRAKQTGfVDIFNFVRAMRQRRPQMVQTPEQYEFIHD
 |   ..... ||| |||   . ||.|.. ... .. .. | ||||||||||||...|..    . |  | ..... .. .|.|||..|..|.|..|...
eregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_CDKN3_pd Subfamily CDKN3 116-214 1.3e-06 22.1 In-house 97-190 (202) alignment 
Range on Protein: 116-214
Range on HMM: 97-190/202.0
RCLDHFHFTRWPDKGVPRNVSVlLRFIQEVNQSRDDkSTPLLVHCSAGVGRTGVVIALDNEMQrAKQTGFVDIFNFVRAMRQRRpqMVQTPEQYEFIHD
..    |    .| .||   |  |....|.. . ..  .  ||||  |.||. .|||    .    .  . |  . .| ..  |   .||  ||.....
qaglivhhypiadglvpdiasc.lkileelrinlka.yrktlvhcygglgrsslviaclllyl.ddtiepkdaidklrdlkgsr..aiqtvkqynylse
PTPc_DSPc_SM00012 119-218 3.7e-36 118.9 In-house 3-105 (105) alignment 
Range on Protein: 119-218
Range on HMM: 3-105/105.0
DHFHFTRWPDKGVPRNVSVLLRFIQEVNQSRDDKS--TPLLVHCSAGVGRTGVVIALDNEMQRAKQT-GFVDIFNFVRAMRQRRPQMVQTPEQYEFIHDA
 |.|.| |||.|||.... .|.....|.... ...  .|..|||||||||||...|||  .|. ... ..||||..|...|..||.|||| ||| |...|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

MLE
.||
lle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 120-219 2.4e-14 47.8 In-house 219-343 (350) alignment 
Range on Protein: 120-219
Range on HMM: 219-343/350.0
HFHFTRWPDKGVPRNVSVLLRFIQ----------EVNQSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQ-----RAKQ----------TGFVDIFNFVRA
....  |.| ..  |   .|. ..            . . ...|.|.||||||||||||....||  ..     .  .            .  |.  |  
qlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivne

MRQRRPQMVQTPEQYEFIHDAMLEF
.|..| .|||. .|. ||..|.| .
lrkqrismvqnldqfifiYeallfy
0038934 (Phosphotyrosine protein) phosphatases II 121-213 2.5e-10 35.8 In-house 82-170 (194) alignment 
Range on Protein: 121-213
Range on HMM: 82-170/194.0
FHFTRWPDKGVPRNVSVLLRFIQEVNQSRDD-KSTPLLVHCSAGVGRTGVVIALDneMQRAKQTGFVDIFNFvraMRQRRPQMVQTPEQYEFIH
..   .||.|.. . ..||||.. |..  .. ..   .||| ||.||||...|    .    .    .  ..   .|..|| ........| ..
ylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaY..LiyrlgmsaeeAial...frekRpgaipnqdyleall
subfamily_PTPDC1_pd Subfamily PTPDC1 121-216 3.3e-09 31.4 In-house 85-172 (182) alignment 
Range on Protein: 121-216
Range on HMM: 85-172/182.0
FHFTRWPDKGVPrNVSVLLRFIQEVNQSRDDKstPLLVHCSAGVGRTGVVIALdnEMQRAKQTGFvdiFNFVRAMRQRRPQMVQTPEQYEFIHDAM
..   |.| ||.  .  .|  .. |... ...   . ||| || |||||.||    .  ||.       . .. .|..||. .|| || |.... .
vynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliac..ylvyakrlta...ekaiklvrskrpksiqtreqvelvkefa
PTEN_1 125-213 3.4e-08 28.5 In-house 101-186 (196) alignment 
Range on Protein: 125-213
Range on HMM: 101-186/196.0
RWPDKGVPrNVSVLLRFIQEVNQSRD--DKSTPLLVHCSAGVGRTGVVIALDneMQRAKQTGFVDIFNFVRAMR-QRRPQmvqTPEQYEFIH
 ..| |.| . | |.... .. ...   ..    |||| ||.||.|.|.|    . ....  . . . .||..| ...|.   .|.| ....
pieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaay..LmykgkltadeAlelvrekRppgapn...spsqerlle
subfamily_VSP_pd Subfamily VSP 128-213 7.7e-06 20.0 In-house 103-192 (212) alignment 
Range on Protein: 128-213
Range on HMM: 103-192/212.0
DKGVPRnVSVLLRFIQEVNQS-RDDKSTPLLVHCSAGVGRTGVVIA---LDNEMQR-AKQTgfVDIFNFVRAMRQ--RRPQMVQTPEQYEFIH
|. ||. .. || | .||..   .|..  | .||  | |||| ..    |  |. . ||..  .| |   |. ..   . | |||| |. ...
dhnvpk.leellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakes..ldyfgerrtdktegekfqGvqtpsqkryvg
subfamily_PTEN_pd Subfamily PTEN 131-213 4.4e-08 28.3 In-house 91-173 (184) alignment 
Range on Protein: 131-213
Range on HMM: 91-173/184.0
VPRNVSVLLRFIQEVNQS-RDDKSTPLLVHCSAGVGRTGVVIA--LDNEMQRAKQTgfvDIFNFVRAMRQRRPQMVQTPEQYEFIH
 | ....| ........    ||.    ||| || |||||.|.  | ....  |..   .. ..  ..| .  . |. | |  ...
nppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekae...ealelfaeaRtknkkgvtiPsqrRYve
subfamily_DSP23_pd Subfamily DSP23 132-214 4.1e-06 21.5 In-house 64-140 (148) alignment 
Range on Protein: 132-214
Range on HMM: 64-140/148.0
PRNVSVLLRFIQEVNQSrDDKSTPLLVHCSAGVGRTGVVIALDneMQRAKQTGFVdifNFVRAMRQRRPQMVQTPEQYEFIHD
|  .  . .|.. |... ..|.  . |||  | |||| ..|    . . ..       . .  .|..||  |.| || . ..|
ppaleqvvefvrvveea.eekneavsvhcllgrgrtgtmlacy..lvkerklaaa...eaiaevrrlrpgsvetveqeklvrd
PTPc_motif_SM00404 136-205 9e-07 23.9 In-house 67-127 (140) alignment 
Range on Protein: 136-205
Range on HMM: 67-127/140.0
SVLLRFIQEVnqsrDDKSTPLLVHCSAGVGRTGVVIALdnEMQRAKQTGFVDIFNFVramRQRRPQMVQT
. .|.||...     .| .  |||| ||| |.. .|.   .. | .|    . ..||   ..|||.. ..
dkvldfiena....ekkggkvlVHCqaGvSRSatliia..Ylmryrqlslaeayefv...kerRpiispn
DSPc Dual specificity phosphatase, catalytic domain 138-206 9.2e-06 20.6 Pfam-A 62-121 (133) alignment 
Range on Protein: 138-206
Range on HMM: 62-121/133.0
LLRFIQEVnqsrDDKSTPLLVHCSAGVGRTGVVIALdNEMqRAKQTGFVDIFNFVramRQRRPQMVQTP
. .||...    ..|    |||| ||. |.. .|.    | . |.    . ..||   ..||...... 
avefieka....eqkgkkvlVHCqaGisRSatliia.Ylm.ktknlslneAyefv...kerrskispna
DSPc Dual specificity phosphatase, catalytic domain 138-206 9.2e-06 20.6 In-house 62-121 (133) alignment 
Range on Protein: 138-206
Range on HMM: 62-121/133.0
LLRFIQEVnqsrDDKSTPLLVHCSAGVGRTGVVIALdNEMqRAKQTGFVDIFNFVramRQRRPQMVQTP
. .||...    ..|    |||| ||. |.. .|.    | . |.    . ..||   ..||...... 
avefieka....eqkgkkvlVHCqaGisRSatliia.Ylm.ktknlslneAyefv...kerrskispna
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 147-218 2.5e-16 54.4 In-house 222-293 (297) alignment 
Range on Protein: 147-218
Range on HMM: 222-293/297.0
QSRDDKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLE
..   ....|||||||||||.|||.  |  ... ..    |.  ... .|..|...||| ||.|...||.|.
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 148-220 9.7e-11 35.6 In-house 260-344 (349) alignment 
Range on Protein: 148-220
Range on HMM: 260-344/349.0
SRDDKSTPLLVHCSAGVGRTGVVIALDNEMQ--RAKQTGFV----------DIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFL
  .|....|||||||| |||||.. ||  ..     |  ..           |.  |  .|. | .|||   |. .|..|.|...
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_CG42327_pd Subfamily CG42327 151-219 5.7e-18 59.6 In-house 245-314 (319) alignment 
Range on Protein: 151-219
Range on HMM: 245-314/319.0
DKSTPLLVHCSAGVGRTGVVIALDNEMQRAKQT-GFVDIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLEF
..  || |||| ||||||.||| | .... ...   ||| . |  .|. | . |.| ||||||.  . |.
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 157-220 1.7e-20 67.2 In-house 2-65 (69) alignment 
Range on Protein: 157-220
Range on HMM: 2-65/69.0
LVHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFL
.||||.| ||||  ||.  || | |   .||||| |. ||. || ||    .| |||||. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 158-220 3.4e-20 66.2 In-house 2-64 (69) alignment 
Range on Protein: 158-220
Range on HMM: 2-64/69.0
VHCSAGVGRTGVVIALDNEMQRAKQTGFVDIFNFVRAMRQRRPQMVQTPEQYEFIHDAMLEFL
||||.| ||||  ||.  || | |   .||||| |. ||. || ||   ..| |||||. | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
0050432 (Phosphotyrosine protein) phosphatases II 223-492 6.6e-64 211.5 In-house 15-284 (308) alignment 
Range on Protein: 223-492
Range on HMM: 15-284/308.0
HDTMIPRDRFIEHFADLRTKSDQDVTLTKLDQEFEIMNKVCHeppMDATNVGKLEENASKNRYQNVLPRDTHRPLLisfstDTSTQYINATFCQGY--KD
.|| |.   .  .  ||  . ..   |..|..||| ...|.    .  ..|..|.|| .|||| ..|| |  |  |     | .. |||| . .||  | 
rdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgysskl

REKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEA---NPNIKQPFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLS
. |.| || ||..|| || |.........||||..|   .      || .    .. .  .|. ..|.. . ...| |||||..   ...|...||....
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytn

WKEVDSVDFYQTLLDFMNNVTSQQgGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
|.. .  .  . ||||.. | ... ...|..||| .||||||.|... ..|.||| |  ||||..|| ||.   .|.|.
WpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
0051299 (Phosphotyrosine protein) phosphatases II 224-492 2.2e-63 209.7 In-house 2-271 (288) alignment 
Range on Protein: 224-492
Range on HMM: 2-271/288.0
DTMIPRDRFIEHFADLRtksdqDVTLTKLDQEFEIMNKVCHEppmDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREK
|| |. . .....  |.        ||.| .||| . ....      .....|.|| .||||...|| |  |  | ... . .. |||| . .||.   |
dteisveellklvlkll.....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk

IITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELK------HRKNTRIIQHFQFLSWK
 | || ||..|| || |.........||||..|   .   .  || . .. .  ... . |.... ...| ||||..        ...|...||....| 
fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp

EVDSVDFYQTLLDFMNNVTSQ-QGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
. .  |  . ||||.. | .. . |..||.||| .||||||.|... ..|.||| |  |||...|| ||.  ..|.|.
dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 226-492 9.3e-51 167.4 In-house 1-268 (290) alignment 
Range on Protein: 226-492
Range on HMM: 1-268/290.0
MIPRDRFIEHFAdlrtkSDQDVTLTKLDQEFEIMNKVCHEppmDATNVGKLEENASKNRYQNVLPRDTHRPLLI--SFSTDTSTQYINATFCQGYKDREK
.|| |.| |. |      ..    ..  ..|. ...  .|    ...||  ..|  .||..|....| .|  |   |   | . .||||.. .|||....
lipvdkfgefva.....nghakgnegfrnqfkmldsgese...htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkq

IITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRKN---TRIIQHFQFLSWKEVD
 | || |.|.|. || .||.. ... |||| .  .|.      || ... .  ..||...|.  . .. .||.||.|....   .......|. .|.. .
yiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstg

SVDFYQTLLDFMNNVTS--QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
.|  .|| |  .....    . |. ...||| ..|||..|||.... ... . |  .||||..| .|    ...|.
kvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqt
subfamily_PTPRB_pd Subfamily PTPRB 227-492 9.6e-55 180.7 In-house 7-270 (293) alignment 
Range on Protein: 227-492
Range on HMM: 7-270/293.0
IPRDRFIEHFADLRTKSDqdvtlTKLDQEFEIMNKVCHEPPMDAtnvGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIIT
|  ..| ||.......||     ... .|.| ...| ..  ..|    .|..|..||||.|.|| |. |  | . ...... |||| . .||. . . |.
iklekfeehvkkmkadsd.....lrfseeyeelkavgkdqavka...aelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefia

TQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--SSIYWDEA-NPNIKQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFY
|| || .|| || |.... . |.|||| .|  .       || .  .| .    ..... . | |.|. |.|.....|..| .....|.|| . .  .  
tqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPekt

QTLLDFMNNVTSQQ---GGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
.|||||...| ...     ..|..|||  ||||||.|  ... |...| || ||.| || .||.. ....|.
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqt
subfamily_PTPRG_pd Subfamily PTPRG 227-491 1.3e-46 154.0 In-house 1-271 (563) alignment 
Range on Protein: 227-491
Range on HMM: 1-271/563.0
IPRDRFIEHFADLRTKSDqdvtlTKLDQEFEIMNKVCHEPPMDATNvGKLEENASKNRYQNVLPRDTHRPLLISFSTDTST-QYINATFCQGYKDREKII
.| ..| .| |.| ...|     .....||| ... . .  .||.   . .||  |||| |... |  |  | . .   ..  |||| . .||.  .. |
vpvkefakhvaslhadgd.....igfseefealqsetiskdldaeh.sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafi

TTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKH--------RKNTRIIQHFQFLSWK
.|| || .|. || |.|.. . ..|||. .| ..      .|| . ..   . ....  ..      |.||| .|.        ... . ...... .| 
atqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP

EVDSVDFYQTLLDFMNNVTS-QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQ
.... ..    | |..     ..    |..||| .||||||...|..  | |.. |.||.||...| .|     ..|
dhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 228-493 4.2e-36 119.3 In-house 3-265 (439) alignment 
Range on Protein: 228-493
Range on HMM: 3-265/439.0
PRDRFIEHFADLrTKSDQDVtltkLDQEFEIMNKVCHEPPMDATNVGKlEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITT
 || | ||  .|  | .|..    ....|| .| .  .   .|. . . | . .||||..| . |  |  |        ..|||| . .|| | .  |.|
grdefqehvekl.dknkqei....fkeifekinstspdyaciaslaaq.eydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiat

QMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAssiYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHR----KNTRIIQHFQFLSWKEVDSVDFY
|.|  .|. || ||... . .||||| .| .      ||   .  .    .. |   .|  ... | . .  .    .. | . .|....| . .     
qgpkkettddfwrlviekktvtivmltnlvesyk...ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqa

QTLLDFMNNVTSQQG--GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSL
  .|||.  . | .      ||.|||  ||||||    . ..|.|| .|. ||.  ||| ||..  ||.|.|
shvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqal
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 235-493 1.8e-50 167.1 In-house 19-277 (319) alignment 
Range on Protein: 235-493
Range on HMM: 19-277/319.0
HFADLRTKSDQDVTLTKLDQEFEIMNKVChePPMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQT
.. .| .||| |  ||||  ||  . |.   ..    .   |..|  |||. |.|. |  .  |        . ||||.| .||. ..| |..| ||  |
yyqqlsnksdfdddltklevefrracklg..vnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldnt

VTDFLRLIYDYRISTIVMLNdlskEDASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMN
. || |.|..|..||||.|     .|  | ||       .. | ..|    |.. .. | .|| .    |. | |. | || | .|   |.   |. ...
ladfWrmiweyncstivllt....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvk

N---VTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSL
.   .||.. .  ...|||  |||||||. |... ||... |. |||...|. || .  ...|.|
kvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl
subfamily_PTPN6_pd Subfamily PTPN6 238-491 2.3e-36 120.4 In-house 15-281 (306) alignment 
Range on Protein: 238-491
Range on HMM: 15-281/306.0
DLRTkSDQDVTLTKLDQEFEIMNKVCHEPPMDaTNVGKLEENASKNRYQNVLPRDTHRPLLIsFSTDTSTQYINATFCQGY--KDREKIITTQMPLSQTV
.|.  ...... . . .||| ...  ..  ..  . |.  ||..||||.|.|| |  |  |   .  . ..|||| . ..   . ... |.||  |..||
elek.eeeslekagfeeefeelqqeeakklls.rkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettv

TDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIKQ-PFSMNVLDTVESEHWTERTLELK---HRKNTRIIQHFQFLSWKEVDSVDFYQTLLDF
.|| |....     |||.        .  . || ... . .    |.. ..  . .... |.| ..   . |..| . ...| || . .     ...|||
sdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdf

MNNVTSQQGGDS-----PVLVHCLNGVGRTGVFCVVKMCLDQLEV---EDAVDVFQIVKALRHDNFQMIQ
...|...|   .     |..||| .|.|||| | |. . |...|    .  .|. ..|| .|.   ...|
ledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvq
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 241-492 6.9e-64 210.9 In-house 18-275 (298) alignment 
Range on Protein: 241-492
Range on HMM: 18-275/298.0
TKSDQDVTLTKLDQEFEIMNKVCHEPPMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLR
.. ... .||....||. .|.| .| . . ..|.. .|| .||||..... |  | .| . ..|  ..||||.| ..||.|.  |.|| || .||.|| |
aavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWr

LIYDYRISTIVMLNDLSKEDA--SSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVT--
.. .. |.|||||..|   |    . || . . .    .....| . |    . |.|.....|  ..| .....| || . .    ....||....|   
mvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvras

SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
 || |..||.|.| .||||.| |....  |.... |  |||||.||.||..  ...|.
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 242-492 2e-49 163.1 In-house 12-263 (287) alignment 
Range on Protein: 242-492
Range on HMM: 12-263/287.0
KSDQDVTLTKLDQEFEIMNKVCHEPPMDATNVGklEENASKNRYQNVLPRDTHRPLLIsfstDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRL
.....   .   . | ....| ...     |.   ..|  |||....|..| .| ||     ..  .||||.| .|||.. . | .. |...|. .| .|
akghakgnegfknqftvleqvtqredevthnia..sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkl

IYDYRISTIVMLNDLSKEDAS--SIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRK---NTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNV--T
| | ....|||| ..  .| .    || | .  .  ......|.   .....||.||.|...   ... .. .|. .|..   |  .|| |  ...   |
iddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
 .. |.....||| ..|||...|| . . ... . | ..||||..|  |    ...| 
qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqt
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 243-483 8.3e-23 75.4 In-house 4-244 (281) alignment 
Range on Protein: 243-483
Range on HMM: 4-244/281.0
SDQDVTLTKLDQEFEimnKVCHEPPMDATNVGKLEENASKNRYQNVLPRDTHRPLL-ISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRL
| | .||  . |||    ..  .|| |   | .   |  |||| |.   |  |  | . .    ||.|| | . .    .   | || |  .| .|| |.
ssqkmtlddfkqefs...nlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrm

IYDYRISTIVMLNDLS---KEDASSIYWDEANPNIK-QPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQ
|..   ..|||| ..    .| ..  .  .|   .. . .|..  |.   .      |.| .  .||.| |. .  | . .  .  . .|  . .. .. 
iwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars

ggdSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDA-VDVFQIVKALR
   .| ..||  ||||.| .  |...|. .    .  |. |||  ||
...tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 245-492 1.2e-56 187.1 In-house 18-268 (319) alignment 
Range on Protein: 245-492
Range on HMM: 18-268/319.0
QDVTLTKLDQEFEIMNKVCHEppmdATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYD
.. . |.|..||. ...   .     ..  . ||| .||||||.|. |  |  | ..    ...||||.| .||..||| | || ||..|. || |....
astgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWe

YRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRKN---TRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTS-QQG
...|..|||..|. .     . ||.|.|..    . .....  | |..  | |.|.....   || ..|||...| . |  .  ..|||.....   ...
eessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek

-GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
  . |. ||| .|||||| |.|... |.... | ..|||..|. ||     |.| 
tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqr
subfamily_PTPN14_pd Subfamily PTPN14 245-493 1.9e-33 110.8 In-house 18-282 (300) alignment 
Range on Protein: 245-493
Range on HMM: 18-282/300.0
QDVTLTKLDQEFEIMNKVCHeppMDATNVGKLEENASKNRYQNVLPRDTHRPLLISfSTDTSTQYINATFCQGY--KDREKIITTQMPLSQTVTDFLRLI
. .  .|. .|.| . |  .      ....||.|||.|||...||| .  |  |.. . ..||.||||.  .      . . |..| || .||.|| ...
kkleegkvfteyeripkkre...dallstaklpenaeknrfkdvlPyednrvelsp.tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmv

YDYRISTIVMLNDLS--KEDASSIYWDEANPNIK----QPFSMNVLDTVESEHWTERTLELKHR--KNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVT
..  .. |||| .      . |  |. . . . |    . | .    . .|.  . ..|.|||   |. | . |.|.  | . .  .  .. |.....| 
WeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevq

SQ----------QGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSL
|           .  . ||||||..|||||||  .. . .  || .. .|. .... ||.    ..|.|
svrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 245-491 1.5e-18 61.5 In-house 19-273 (305) alignment 
Range on Protein: 245-491
Range on HMM: 19-273/305.0
QDVTLTKLDQEFEIMNKVCHePPMDA--TNVGK-LEENASKNRYQNVLPRDTHrplLISFSTDTSTQYINATFCQGYK-DREKIITTQMPLSQTVTDFLR
 || . || .||  . |    | |     |  .  . . .|||||.|  .|     .. ..  . ..|| | .         ..| .| || ||. .|  
ldvgvdklreefrglakytr.pdmtqvafnanqsadiaitknryqdvpcqdqs...avkldkpspsdyihanyvgcpmipekrficaqgpldqtidefww

LIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELK-------H-RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFM
.. . ..  ||||    .      . ||  |. . ..  |  |.. |   .  ||  |..       .  ...  ..|.|.  | .        | |...
mviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslell

NNVtsqQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQL-EVEDAVDVFQIVKALRHDNFQMIQ
  .   .|   |..|||  |.||||    ..  |... |  ..  . ..||||| .    ||
sai...rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiq
0036941 (Phosphotyrosine protein) phosphatases II 246-492 9e-58 191.3 In-house 9-262 (297) alignment 
Range on Protein: 246-492
Range on HMM: 9-262/297.0
DVTLTKLDQEFEIMnkvCHEPPMDATNVGKLEENASKNRYQNVLPRDTHRPLLisfsTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDY
   |..| .||| .   ..  ..  ..|..|.|| .|||| ..|| |  |  |    .| .. |||| . .||.   |.| || ||..|| || |.....
llflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

RISTIVMLNDLSKEDA--SSIYWDEA--NPNIKQPFSMNVLDTVE--SEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQ
....||||..|   .      || .   ..    .|....|.. .  ....| ||||...   ...|...||....| . .  . ...||||.. | ...
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

G---GDSPVLVHCLNGVGRTGVFCVVKMCLDQLE---VEDAVDVFQIVKALRHDNFQMIQS
    ...|||||| .||||.|.|... ..|.|||    |  ||....|| ||.  ....|.
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqt
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 246-491 2.1e-21 71.2 In-house 12-261 (307) alignment 
Range on Protein: 246-491
Range on HMM: 12-261/307.0
DVTLTKLDQEFEIMNKVCHEppmdATNVGKLEENASKNRYQNVLPRDTHRpLLISFStDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDY
|  ...| .||... |   |    . .|  .. |. |||||.|  .|  | ... |.   ...|| | .     .  |.| .| || .|. .|  .. . 
dkgvqalvdefrvlakktpe....gvtveafsantdknryqdvkcqdkgr.ivvkfd.glasdyihanylgiaikpkkficaqgplentqysfwamaiqe

RISTIVMLNDLSKED--ASSIYWDEANPN----IKQPF--SMNVLDT----VESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSvdfYQTLLDFMNNV
.. ...|| .. .        ||   . .     ..|   |.. | .     . .     ||...  ...| |||.|.  | .       |. |  .| .
kvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgv...pqinltainll

TSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQL-EVEDAVDVFQIVKALRHDNFQMIQ
 . ..   ||.|||  ||||.|    . .  |.. . ..  |. ..|. || .    ||
eavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiq
0047943 (Phosphotyrosine protein) phosphatases II 247-492 2.8e-59 196.2 In-house 9-257 (273) alignment 
Range on Protein: 247-492
Range on HMM: 9-257/273.0
VTLTKLDQEFEIMNKVCHeppMDATNVGKLEENASKNRYQNVLPRDTHRPLLisfsTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYR
  ||.| .||| . ....   .  ..|..|.|| .||||...|| |  |  |    .| .. |||| . .||.   |.| ||.||..|| ||.|......
lgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

ISTIVMLNDLSKEDA--SSIYWDEAN---PNIKQPFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQG-
...||||..|   .      || . .   . .  .|. ..|.. . ...| |||||..   ...|...||....| . .  . .. ||.|.. | ...  
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
  ...||.||| .||||||.|... ..||||| |  |||...|| ||   . |.|.
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqt
0039614 (Phosphotyrosine protein) phosphatases II 247-492 9.9e-58 191.3 In-house 29-274 (297) alignment 
Range on Protein: 247-492
Range on HMM: 29-274/297.0
VTLTKLDQEFEIMNKVCHEppmdaTNVGKLEENASKNRYQNVLPRDTHRPLLISFST-DTSTQYINATFCQGYKD-REKIITTQMPLSQTVTDFLRLIYD
   |.|..||| . .. ..     . ...|.|| .||||...|| | .|  | ..   | .. |||| . .||.    |.| || ||..|| ||.|....
nsktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

YRISTIVMLNDLSKEDA-SSIYWDEANPnIKQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQG---GD
.....||||..|   .     || |       .|. ..|.. . ...| ||||... . .|...|||...| . .  .  ..||.|.. | ...    ..
qgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkg

SPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
 |||||| .||||||.|..  ..|.||| |  |||...|| ||    ...|.
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqt
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 247-492 5.3e-12 39.8 In-house 23-270 (302) alignment 
Range on Protein: 247-492
Range on HMM: 23-270/302.0
VTLTKLDQEFeimnKVCHEPPMDATNVGKLEENASKNRYQNVLPRDTHRpllISFsTDTSTQYINATFCQGYKDREKIITTQMPLSQTV---TDFLRLIY
.. ... .||    | ...  .|. .     .| .||. ..|   |...   .   . .  .|.||.  .  . ...|| .|.| ....    .| |...
ldtaevkkef....kkidtmkvdlekCkafkknlkknqsedvpildsnl...vkl.eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvf

DYRISTIVMLNDLSKED--ASSIYW--DEANPNIKQPFsMNVLD--TVESEHwTERTLEL--KHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNV-T
. .| ..|.|    . .   | ..    ..  . .. | .|.     .| |. |. ..|.  .   |. ...   .  ||.    . | .|   . .| .
qekivsvvilvgeeelkktlselfpkksgdykeygkmf.vNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfa

SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
... .|.....   ||.|| |.| .. . ...|. .... . .|||..| .  ....|
kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravds
0045450 (Phosphotyrosine protein) phosphatases II 248-492 3.1e-55 183.4 In-house 25-289 (307) alignment 
Range on Protein: 248-492
Range on HMM: 25-289/307.0
TLTKLDQEFEIMNKVCHEPpMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTD-TSTQYINATFC--------QGYKDREKIITTQMPLSQTVTDF
 ||.| .||| ...|....  . .....|.|| .||||...|| | .|  | | . .  .. ||||..         .||.   |.| || ||..|| ||
fltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

LRLIYDYRISTIVMLNDLSKEDA--SSIYWDEA-NPNIKQPFSMNVLDTVESEHWTERTLELK---HRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNN
.|.........||||..|   .      || .   .    .| ...|.. . ...| ||||..     ...|...||....| . .  .. ..||||.. 
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

VTSQQG---GDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDA---VDVFQIVKALRHDNFQMIQS
| . ..   ...||||||  ||||||.|..  ..|.||| |     ||....|| ||    ...|.
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqn
subfamily_PTPN12_pd Subfamily PTPN12 249-492 2.6e-43 143.0 In-house 7-262 (290) alignment 
Range on Protein: 249-492
Range on HMM: 7-262/290.0
LTKLDQEFEIMNKVCHEPPMDA---TNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDY
  .. .||. . |. ..  ...   |..|. |||  ||||...|| |. |  |   . .   .|||| | .| ... . | .| ||..|..|| |.|...
eeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwek

RISTIVMLNDLSKED--ASSIYWDEANPNI--KQPFSMNVLDT-VESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQ-GG
... .||.  .   .      || | . .    ..|.... .    .. .. |||.....|..|... |.. .| . .     ..||.....| . |   
nveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqese

DSPVLVHCLNGVGRTGVFCVVKMCLDQLEV---EDAVDVFQIVKALRHDNFQMIQS
|.|..|||  ||||||. ... .  ..|.    .. .|||..|  ||..   ..|.
daPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqt
subfamily_PTPN23_pd Subfamily PTPN23 249-491 3.3e-38 126.2 In-house 14-264 (288) alignment 
Range on Protein: 249-491
Range on HMM: 14-264/288.0
LTKLDQEFEIMNKVCHEPpMDATNVGKLEENASKNRYQNVLPRDTHRPLLIsfstDTSTQYINATFCQGYKDR-EKIITTQMPLSQTVTDFLRLIYDYRI
 |.||..|. ...  ..     . .   . ...|||....|| |  |  |     ..   ||||.| ..      ..|.|| || .|. || ...|. . 
ktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

STIVMLNDLSKEDAS--SIYWDE--ANPNIKQPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTS-----Q
|.|||| . .. .    . || |   ...  ...|. . .. |.|.. ||.|.|....  ... ..| |. || |.   .  .|||.|...| |     |
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavq

QGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDA-VDVFQIVKALRHDNFQMIQ
.  . |..|||. ||||||||..|   . .||...  .|. |.|. ||..   |.|
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvq
subfamily_ptpA1_pd Subfamily ptpA1 249-484 1.4e-23 78.4 In-house 20-277 (418) alignment 
Range on Protein: 249-484
Range on HMM: 20-277/418.0
LTKLDQEFEIMNKVCHepPmDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDReKIITTQMPLSQTVTDFLRLIYDYRIS
. |. .|| ....     |   |. |  . |.||||| |.|| .  |  |        ..|||| . .|   . ..| || || .|..|| |.... |  
ihkikeefrlleesvg..p.setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcr

TIVMLNDLSKED--ASSIYWDEAN--------PNIK---QPFSMNVLDTVESE--HWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNV
 ||||.  |..       || |           | .     .|..... ..        | . |    .|| | ..|.  | . .  |. | . ... ..
iivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsi

TSQQG-------GDSPVLVHCLNGVGRTGVFCVVKMCLDQLE----VEDAVDVFQIVKALRH
| .|         . |..|||  |||||| ||   . . .|.      ||  . |.|  . |
tnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkqldatpidqvvdpfth
subfamily_eak_pd Subfamily eak 249-432 3.3e-10 33.9 In-house 22-206 (332) alignment 
Range on Protein: 249-432
Range on HMM: 22-206/332.0
LTKLDQEFEIMNKVCHEPPMDATNVGKLEENASKNrYQNVLPRDTHRPLLISfSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRIS
  ...|  .|.... .  .. . ....  |.  .|   ...|.| .   | | |      ||||.  .  .  .| | | ..  . |  | ..... .  
wnrinqrinivadlddyqrllsisetarleavnrn.vvkivpydrylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqksp

TIVMLNDLSKED--ASSIYWDEAN-PNIKQ-PFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDsVDFYQTLLDFMNN
.||.| .  ...   |  |. .    ..|   . ..  . |. .    | |||.   .|  ..|...  | |.. .  |. .| . . 
aivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtett.lpkyedflalrkv
0040438 (Phosphotyrosine protein) phosphatases II 250-492 1.8e-58 193.6 In-house 18-261 (317) alignment 
Range on Protein: 250-492
Range on HMM: 18-261/317.0
TKLDQEFEIMNKVchepP-MdATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRIS
|.| .||| . ..    .    ..|..|.|| .|||| ..|| |  |  | ... | .. |||| . .|.. . |.| || ||..|| ||.|........
talleefedllsl....kld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

TIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGG-DSPV
.||||..|   .   .  || . ..    .|....|...| ...| ||||...   ...|...||....| . .  .  ..||||.. | ... . ..||
vivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpv

LVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
|||| .||||||.|... ..|.||| |  |||...|| ||.   ...|.
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 250-492 1.3e-56 186.8 In-house 21-264 (288) alignment 
Range on Protein: 250-492
Range on HMM: 21-264/288.0
TKLDQEFEIMNKVCHeppMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRIST
| . .|.. . .. .    .....|.| .||.||||.|.|| | .|  |    . ... ||||.. .|.| ..| |.|| || .|| || .|.|....||
tgfseeynsLaalek...tksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

IVMLNDL--SKEDASSIYWDEA-NPNIKQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGD-SPVLV
||||..|    .     || .| .|.    . . .... | |....|.|.|...|. . |...|.|.| . .  .  . ||.....|  ..  |  |..|
ivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiiv

HCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
|| .||||||.| .... .|..| || .||. .|. ||.  ....| 
hCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqt
subfamily_Ptp69D_pd Subfamily Ptp69D 250-493 1.3e-51 170.6 In-house 22-272 (307) alignment 
Range on Protein: 250-493
Range on HMM: 22-272/307.0
TKLDQEFEIMNKVchEPPmDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRIST
  | .|.| ...   | .   |.|.. .||| ||||... . | .|  |     . ...|||| | .|||...| |. | |. .|. || |.| .  . .
fglakeyekLear..eid.kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtl

IVMLNDLSKEDA--SSIYWDEAnpNIKQPFSMNV--LDTVESEHWTERTLELKHRK-------NTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNV-TSQQ
|||| .|.  .    . || .   ...|  ...|   .. . .....|.|.. . |       ..| .  .....||..   .  ..||.....|   ..
ivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyk

GGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSL
   ||..||| .||||.|.|  ... |.||. || ||.|..|| ||..   ..|||
lnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsl
subfamily_PTPRN_pd Subfamily PTPRN 250-491 5.2e-37 122.2 In-house 29-276 (297) alignment 
Range on Protein: 250-491
Range on HMM: 29-276/297.0
TKLDQEFEIMNKVCHEPpmDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREK-IITTQMPLSQTVTDFLRLIYDYRIS
..|..|.| . .   ||   ...|.| |.|..|||...||| |  |  | . .......||||..      |.   |.|| ||..||.|| .....  . 
drlekewealcayeaep..stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

TIVMLNDLSKEDASSI--YWDEANPNIKQPFSMNVL-DTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVT-SQQGGDSP
 ||.|  |..|. .    || .   .. . . .... . . .. .  |.. ||    ..|| .  | ||||.| .     ..||.|   |  | .|  .|
vivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscp

VLVHCLNGVGRTGVFCVVKMCLDQLEV-EDAVDVFQIVKALRHDNFQMIQ
..||| .|.|||||.... . |..|      .|.   .. || .  ....
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvk
subfamily_egg_pd Subfamily egg 250-464 1.7e-13 44.9 In-house 14-225 (307) alignment 
Range on Protein: 250-464
Range on HMM: 14-225/307.0
TKLDQEFEIMNKVCHEPPMDATNVgklEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRIST
 .|.. .|.......| ..  .     ..|  | | . |  .|. |  |       . ..| |   .|    .. | .| ||  || || |...  ..  
qelerrlevleesvdeislttaas...dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqy

IVMLNDLSKEDASSIYWDEANPN--IKQP--FSMNVLDTVESEHWTERTLELKHR---KNTRIIQHFQflsWKEVDSVDFYQTLldfmNNVTSQQGGDSP
||||.   . .    ||  |. .  .  |  . .. |.  .      |  .||     .. | ..|.|   .    | | |  |    . .   .    |
ivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq...gdvnnssdvyspl....rvlrklrnlskp

VLVHCLNGVGRTGVFCVVKMCL
|.|.. .|| .....  ... |
vvvqdilGvskaatlvaieial
0043336 (Phosphotyrosine protein) phosphatases II 251-492 5.9e-57 188.6 In-house 21-262 (278) alignment 
Range on Protein: 251-492
Range on HMM: 21-262/278.0
KLDQEFEIMNKVCHeppmDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTI
.| .||| .... .    | .....|.|| .|||| ..|| | .|  | ... | .. |||| .  ||.  .|.| || ||..|| || |........||
llllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

VMLNDLSKEDA--SSIYWDeANPNIKQPFSMNVLDTVESEHWTERTLELK--HRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQG-GDSPVLV
|||..|   .   .  ||   ..    .|. ..|.. . ...| ||||..    ...|...|...|.| . .  .  ..||||.. | ...   ..||||
vmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlV

HCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
|| .||||||.|... ..|.||| |  ||....|| ||.  ....|.
HCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 251-491 3.1e-53 175.9 In-house 21-264 (318) alignment 
Range on Protein: 251-491
Range on HMM: 21-264/318.0
KLDQEFEIMNKVCHePPMdATNVgKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTI
.|..|.| .... .  .  ...    . |. ||||.|.|. |. | .|  ....... |||| . .||. ... | .| ||..|..|| |....   ..|
llseeyerlsrsee.tvt.slks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavi

VMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQ--GGDSPVL
||| ... .       || . ...  .   ... ..||..... |........  ..|... ... || . .. .   .|||.. .|.. |   | .|..
vmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpiv

VHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQ
|||  ||||||||..|.. |.... |  |||||.|| ||.    |.|
vhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 251-492 5.8e-37 122.0 In-house 11-262 (287) alignment 
Range on Protein: 251-492
Range on HMM: 11-262/287.0
KLDQEFEIMNKVCHEPPMDATNVGKLeENASKNRYQNVLPRDTHRpLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTI
..|.|.. . .  .  ..   .  .|  ...|||| .||| |  | .|.|  ..  ..|||| .  .|.| |. |..| |.. || || |.... | ...
dvdkevdalkedsesstatfkaaeel.aavkknryadvlPiddtr.vllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasv

VMLNDLSkEDASS---IYWDEAN-PNIKQPFSMNVLD-TVESEHWTERTLELKHR--KNTRIIQHFQFLSWKEVD----SVDFYQTLLDFMNNVTSQQGG
...     |.|      || | . |     .|. .|| .. . ... |.| | .   ...|... ...||| .      .| . .  ||  ...  .. .
itmtrev.eearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielarda

--DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
    |..||.  |.||.|..  . .....||    ||| ..|  ||     ..|.
sevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqa
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 251-492 2.8e-32 106.8 In-house 7-244 (267) alignment 
Range on Protein: 251-492
Range on HMM: 7-244/267.0
KLDQEFEIMNKVCHEPPMDATNVGklEENASKNRYQNVLPRDTHRpLLIsfStDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTI
....||| ..|. ..    .. ..  |.|. .||....|| |  | . .  . ..  .||||.. .||| ... | || ||..|.|||| .| |.....|
eiekefelikkisdtsstisqsia..eknqernrlddnlpyddtr.vil..r.tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLNDLSKEDaSSIYWDEANPNIKQPFSMNVLDTVESE--HWTERTLELKHRKNT-RIIQHFQFLSWKEV-DSVDFYQTLLDFMNNVtSQQGGDSPVLVH
|.|    ...    .|     . |.   . |  ..| |   .   ||||| .... . .  . .  |.   .   . . |.  . .    . |. |..|.
vlltkvftdn.irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilakn.qlengnrPlvva

CLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
| .||||.| | |..  |...  |. .|.|. .. .|.    ....
csdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdt
0046845 (Phosphotyrosine protein) phosphatases II 252-492 1.3e-59 197.3 In-house 2-259 (284) alignment 
Range on Protein: 252-492
Range on HMM: 2-259/284.0
LDQEFEIMNKVCHEPPmDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTD-TSTQYINATFCQGY-----KDREKIITTQMPLSQTVTDFLRLIYDY
|..||| .... . .    ..|..|.|| |||||...|| |  |  | |.. |  .. |||| . .||     . . |.| ||.||..|| || |.....
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RISTIVMLNDLSKED--ASSIYWDEAN-PNIKQPFSMNVLDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGG
....||||..|   .    . || . . . .  .|. ..|.. . ...| |||||..    ...|...||...|| . .  .  . ||.|.. | ...  
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

---DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVED---AVDVFQIVKALRHDNFQMIQS
   ..|..||| .||||||.|... ..|.||| |.    |||...|| ||   ..|.|.
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
DSPc_SM00195 252-492 1.4e-55 183.8 In-house 2-247 (263) alignment 
Range on Protein: 252-492
Range on HMM: 2-247/263.0
LDQEFEIMNKVCHEPpmdATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIV
|..||| ...  ..     |. .. ..| |||||.|.|| |  |  | .  ......|||| . .|.. ..|.| ||.||..|| || |.... ....||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDLSKE--DASSIYWDEA--NPNIKQPFSMNVLDTVESE-HWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGG-DSPV
||.. ...     . || |   ...  . .| .. .. . . ... |||||.. .  .|| ....|. .|.. .  |  . .|.... |....   ..|.
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
.||| .||||||.|......|..|| |. ||.|.|||.||.  ..|.|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt
PTPc_SM00194 252-492 1.4e-55 183.8 In-house 2-247 (263) alignment 
Range on Protein: 252-492
Range on HMM: 2-247/263.0
LDQEFEIMNKVCHEPpmdATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIV
|..||| ...  ..     |. .. ..| |||||.|.|| |  |  | .  ......|||| . .|.. ..|.| ||.||..|| || |.... ....||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDLSKE--DASSIYWDEA--NPNIKQPFSMNVLDTVESE-HWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGG-DSPV
||.. ...     . || |   ...  . .| .. .. . . ... |||||.. .  .|| ....|. .|.. .  |  . .|.... |....   ..|.
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
.||| .||||||.|......|..|| |. ||.|.|||.||.  ..|.|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 252-492 6.3e-46 151.5 In-house 8-251 (283) alignment 
Range on Protein: 252-492
Range on HMM: 8-251/283.0
LDQEFEIMNKVCHePPMDaTNVGKLEENASKNRYQNVLPRDTHRPLLISFSTdtstQYINATFCQ---GYKDREKIITTQMPLSQTVTDFLRLIYDYRIS
 .  .| .....  |..| ...   .||  |||.|...| | .|  | | |     .||||.|      ||. .| | .| || .|| || ....| .|.
nklfrevlkrlsv.pdld.adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

TIVMLNDLSK--EDASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHR---KNTRIIQHFQFLSWKEVDSVDFYQTLLDFmNNVTSQQG--GDS
.||||  |    . . | || .       .| . . . . |. .. . | |..    |.| .. |.|.  | |..      .|. | | | |.|    ..
aivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvislqteskkg

PVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
|..||| .|.|||.||. .   ....  |  ||||..|| .| .   ..|.
PivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 252-492 6.8e-42 138.5 In-house 17-261 (281) alignment 
Range on Protein: 252-492
Range on HMM: 17-261/281.0
LDQEFEIMNKVCHEPPMDATnvgKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIV
. .|.| ....  . .  |.   | .||  ||||.|.   |  |  .   .....| |||| |..|||. .. |.|| |. .....| ........|.||
fieeyeklaaigvdntatas...kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLNDLSKEDA--SSIYWDEANPNIK-QPFSMNVLDTVESEHWTERTLEL-KHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQG--GDSPVLV
|.    ...      || . | ..|   . .. . . |.... ||...| ..  .|| ........| .    .  . ||.| ..|.. .    . |...
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCLNGVGRTGVFCVVKMCLDQLEVE-DAVDVFQIVKALRHDNFQMIQS
||  ||||||..  .   ....| |   .|| ..|. ||..   |.|.
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqt
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 252-483 3e-14 47.4 In-house 24-263 (305) alignment 
Range on Protein: 252-483
Range on HMM: 24-263/305.0
LDQEFEIMNKVCHEPPMDATnvgKLEENASKNRYQNVLPRDTHRPLLisfSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIV
| .||  |...     | |    |  ..| ||||..|   |  |  |    .    .|| | .     . ...| || || .| .||  . .. .. .| 
lraefvamkrfndfekmkaf...keaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaif

MLNDLSKED------------ASSIYWDEANPNIKQPFSMNVLDTVESE-----HWTERTLELKhRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVT
|| .| .                 . ..| .  |   |   |    ...       |. ..|    ...| ..|. .  | .       ...|.....  
mlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvpaadlailellekar

SQQGgdsPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVD-VFQIVKALR
. .|   |. |||  |.||||   ...  ||||   . ..   .|.. .|
pskg...pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkir
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 252-328 8.9e-09 29.4 In-house 21-94 (95) alignment 
Range on Protein: 252-328
Range on HMM: 21-94/95.0
LDQEFEIMNKVCHEPPMDATNVGKLEENASKNRYQNVLPRDTHRpllISFSTDTSTQYINATFCQGYKDREKIITTQ
 ||||.   |        .  ||  | |  |||. |..| |. |   . ..|   ..|||| | .||  ..  |..|
sdqefdnefksismtsgapytvgsseanipknrflnifpydatr...vvlttkrdsdyinacfvdgyarkncyiaaq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 253-493 1.2e-57 190.4 In-house 21-269 (305) alignment 
Range on Protein: 253-493
Range on HMM: 21-269/305.0
DQEFEIMNK-VCHEppMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIV
|...|   | ...|   ....||| |.|..|||.... . |..|  |   ...  ..||||.. .||| ..| |..| || .||.|| |||.....||||
dkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLNDLSKED--ASSIYWDEANPN--IKQPFSMNVLDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGD--SP
|| .| ...      || |.  .    ..||... .. . . ..|| |..      |..| . ..|. .| .   ..|  .||.....|. .|  |   |
mltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvp

VLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSL
.|||| .||||||||..|.. |..|. |. ||||...|.||.   .|.|.|
llVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl
subfamily_PTPN13_pd Subfamily PTPN13 254-492 3.4e-37 123.2 In-house 15-254 (273) alignment 
Range on Protein: 254-492
Range on HMM: 15-254/273.0
QEFEIMNKVchePPMDATNVGKLEENASKNRYQNVLPRDTHRPLLisfSTDTStqYINATFCQG--YKDREKIITTQMPLSQTVTDFLRLIYDYRISTIV
.||. ....    |.| ..||| .|| .||||.|||| |  |  |   . ...  ||||.. .    ||. . | .| || .||.|| ..... . . |.
eefkelrel...kpldtcevgkkkenkdknryrnvlPydetrvkl...gdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MLN-DLSKED-ASSIYWDEANP---NIKQPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGDSPVL
|.  .  |.      || | .     ... . ...|.... . .. |.|..|. .  ..| ..|..| .| . .     . || |. .| . |   .|..
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPiv

VHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
|||  |.||.|.. .... |. .| .  .|| .||. ||.    ..|.
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 256-493 5e-40 132.1 In-house 17-279 (301) alignment 
Range on Protein: 256-493
Range on HMM: 17-279/301.0
FEIMNKVCHEPPMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFST--DTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVML
||   |  .|   . ..||  |||.  ||..|. . | .| .|   ..   ....||||.. .||....| | .| |. .|..|| |||.... ..|||.
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmv

NDLSKE--DASSIYWDEANPNIK--QPFSMNVLDTV-----------------ESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNN
 .| ..  . .  || ... . .   ||.. . ..                   ..  .||... |..|... .  .|  .| .   |  ..| |  ...
tnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvidd

VT--SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSL
|    |. | .||.||| ..|.|.||.| | . |.|   |  |||||..||.|.    ... |
vihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTL
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 256-491 6e-24 79.2 In-house 31-267 (290) alignment 
Range on Protein: 256-491
Range on HMM: 31-267/290.0
FEIMNKVCHEPPMDATNVGKLEENA--SKNRYQNVLPRDTHRPLLisfSTDTSTQYINATFCQGYKDreKIITTQMPLSQTVTDFLRLIYDYRISTIVML
 | ..|.    | .  .   ...|.   ||||..|   |  | .|   .     .|. | . .| |    .| || .| .|| |. |.. . ....||||
keyleklkpylpvqylerkifdkntefkknrykdvvcndktrvil...kdGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivml

NDLSKEDA--SSIYWDEANPNIKQPFSMNVLDTVE---SEHWTERTLELKHRKNT--RIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGgdsPVLVH
 .| ..     . |. | . ..    .. || . |    ..   .|| ......    ...|..  || .        .||  .  .    |   || ||
celiedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG...pvvvh

CLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQ
|  |.|||| |  ....|. |    ..|. ..|.|||.   . .|
csaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 257-492 1.9e-23 77.9 In-house 19-256 (288) alignment 
Range on Protein: 257-492
Range on HMM: 19-256/288.0
EIMNKVCHEPPMDAT--NVGKLEENASKNRYQNVLPRDTHRPLLIsfstDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLN
| ..|  .. | .|.   . .  .|....||.|.   |. |  |     | .  ||.|      | ....| .| ||  |.  . ... .  .  ||||.
eglkkeyrdspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlc

DLS-KEDASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQ------FLSWKEVDSVDFYQTLLDFMNNVtsqQGGDSPVLVHC
.|  |    |  .   .   |  .  .  .. ..    ......   .... ... .      .| |..    . |.. | ... .   .  . |..||.
ellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl...kslqkPivvhs

LNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
 .|||||| . .. . |..| ..| . . .... || . |. ||.
saGvGrtgtlililialeslrlddflgirsllaklreerfkaiqt
subfamily_PTPN1_pd Subfamily PTPN1 258-491 9.7e-32 104.8 In-house 11-255 (290) alignment 
Range on Protein: 258-491
Range on HMM: 11-255/290.0
IMNKVCHEPPMDATNVGKLEENASKNRYQNVLPRDTHRPLLisfsTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLS
|.... .|     |.. ||.|| ..|||..| | |  |  |     .....||||.. .  . . . | || ||..||. | ..... .  ..|||| . 
iyldirkeasdfptreaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvv

KEDA--SSIYWDEANP--NIKQP---FSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVT---SQQGGDSPVLV
 ..      || . .   ...     ...... . .....| |.|||.    ..|| | || ...| .    .  ...|.|. .|    | .    |...
ekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavi

HCLNGVGRTGVFCVVKMCLDQLEVEDA---VDVFQIVKALRHDNFQMIQ
||  |.||.| ||.|  || ..| .|    ||. . . .||.  . .||
hcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliq
subfamily_PTPN9_pd Subfamily PTPN9 261-491 6.6e-44 145.1 In-house 24-274 (297) alignment 
Range on Protein: 261-491
Range on HMM: 24-274/297.0
KVCHEPPMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKED
.. .||.    .. ||  | .||||..||  |  |  | . . |. . |||| |..||| .. .|.|| || .||.|| |.... .. .|||   .  . 
eirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvverg

--ASSIYWDEANPNIKQ--PFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQG--------------GD
    . ||.. . . ..   .|.......|.|....|.||.|.   ...| . ||||||| .    .  ..|||....| ..|.               .
rlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsg

SPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQ
 |..|||  |.|||| |. . .||..|| .. |||.. || ||     .||
PPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiq
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 262-493 2.7e-47 156.6 In-house 7-241 (284) alignment 
Range on Protein: 262-493
Range on HMM: 7-241/284.0
VCHEPPMD-ATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNdlskED
.|. ..     .   |..|  |||. ..|. |  .  |        . ||||.| .||. ..| |.|| ||  |. || |.|..|..||||.|     .|
acklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt....kd

ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNN---VTSQQGGDSPVLVHCLNGVGRT
  | ||       .. | ..|    ||| .. | .|| .    |. | |. | || | .|   |.   |. ....   .||.. . ....|||  |||||
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSL
||. |... ||... |. |||...|. || .  ...|.|
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 264-439 2.3e-23 77.2 In-house 30-167 (392) alignment 
Range on Protein: 264-439
Range on HMM: 30-167/392.0
HEPPMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDass
 .|..  ..|.. | |  ||||.|.|| |. |  |      . ..|.||.. ....  .  |..|.| . .. || |.... ...||.|...| . |   
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...

iywdeanpnikqpfsmnvldtvesehwtertlelkHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGG
                                   . ...| .  |.|  | . |   .  .|| |...| .. | 
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq
subfamily_PTPRD_pd Subfamily PTPRD 265-492 5.4e-63 208.5 In-house 34-266 (564) alignment 
Range on Protein: 265-492
Range on HMM: 34-266/564.0
EPPMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--S
|..   ... . ..| .||||.|... |. |  | ..  | .. ||||.|..||. |.. | || ||..|. || |.......||||||. |. ..    
egqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkc

SIYWDEANPNIKQPFSMNVLDTVESEHWTERTLEL--KHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQG-GDSPVLVHCLNGVGRTGVFCV
. || | ..   . .  .. ...| .. . ||..|  |.....| ...|.| || . .  .. ..|||....|.. .  .  |..||| .||||||.|.|
hkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfiv

VKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
....|.... |. ||..|.|||||..   |.|.
idamlerikeektvDiyqyvkalrkqRnamVqt
subfamily_PTPRK_pd Subfamily PTPRK 265-492 1.1e-56 187.0 In-house 29-262 (314) alignment 
Range on Protein: 265-492
Range on HMM: 29-262/314.0
EPPMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKED--AS
|  ..  .. | .|| .|||....|. | .|. ||.   |.|..||||..  .||  .. | || || .||.|| ||.||.. ..||||..| ..     
eslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkC

SIYWDEANPNiKQPFSMNVLDTVESEHWTERTLELKH----RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQ-QGGDSPVLVHCLNGVGRTGVF
. || |      ... .....|   .    |.. ...     ...|....||||.| . |     ..||... .| .. . .. ...|||..| ||||.|
lkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtf

CVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
..... || .| |. ||||..||.||     |.. 
iaidivldmieregvvdvfnavktlrsrkvnmvet
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 265-492 5.3e-50 165.0 In-house 30-262 (315) alignment 
Range on Protein: 265-492
Range on HMM: 30-262/315.0
EPPMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--S
.|..  ..|.. ..| .||||.|.|| |. |  |     .    ||||.. ....| .  |..|.||  .| || |........||||.......|    
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc

SIYWDEANPNIK--QPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGG-DSPVLVHCLNGVGRTGVFCV
  || . . .      .....|..      . | | ... ...| .  |||  | .  .     .|| .. .| ...|  . ..||||. |||||||.. 
rqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvis

VKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
.. ...|.. ...||||..|| || .  ...|.
idevvaqikrtrsvdvfnfvknlrakrpylvqt
0045098 (Phosphotyrosine protein) phosphatases II 266-492 1.3e-49 164.4 In-house 20-257 (278) alignment 
Range on Protein: 266-492
Range on HMM: 20-257/278.0
PPMDATNVGKLEENASKNRYQNVLPRDTHRPLlisfstdtstQYINATFCQGYkdREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASS
....  ... ...|..|||| ..|| |  |             ||||.. .||  . | | || || .|| ||.|......|..||||..|   .     
gipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

IYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKHR----KNT--RIIQHFQFLSWKEVDSVDFY--QTLLDFMNNVTSQQG--------------GDS
 || | .. .  .|. ..|.. . ...| |||.. .     ..   | ..|...|.| . .. ..   . .|.... . . .               .. 
qywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PVLVHCLNGVGRTGVFCVVKMCLDQLevEDAVDVFQIVKALRHDNFQ-MIQS
||||||  ||||||..... ..|..|  |. ||....|| ||    . ..|.
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqn
subfamily_PTPN3_pd Subfamily PTPN3 266-492 5.3e-39 128.8 In-house 28-260 (280) alignment 
Range on Protein: 266-492
Range on HMM: 28-260/280.0
PPMDATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTdtstQYINATFCQ----GYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA
 |  |... .. ||.|||||...|| |. |  | . .|     |||| . .    . .   . |.|| ||..|.||| ..... ..|.|||| .|  .  
kpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr

--SSIYWDEANPNIK-QPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQ-GGDSPVLVHCLNGVGRTG
     || | . ...   ||...  . |.. .  | | ||...  . | | ..|.|.| . .  |  . .|.|...| ... | ..||.|||  |.||||
vkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtG

VFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
|. .....|  .| ...| . .||. .|     ..|.
vlilletalalieaaepvypldivrtmrdqramlvqt
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 267-492 3.5e-45 149.2 In-house 15-253 (274) alignment 
Range on Protein: 267-492
Range on HMM: 15-253/274.0
PMDA-TNVGKLEENASKNRYQNVLPRDTHRPLLIS-FSTDTSTQYINATFCQGYKDREKI-ITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA--
|..  ..  ..  ...||||...|| .. | || |  |.|  ..|||| . .||. ..|. . || ||..||.|| |.||  ... |||| .|. ..   
PlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqk

SSIYWDEANPN-I---KQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQ---GGD-SPVLVHCLNGVGR
 . |. .|.   |    . ....| ..|| .... |.| ||. ...| ..|. . .| . .| |  .||||....| ...       .||.|||  |.||
CavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGr

TGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
||.|  ..... ||. |  |||..||  || |   |.|.
tGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqt
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 267-364 1.5e-08 28.6 In-house 26-127 (347) alignment 
Range on Protein: 267-364
Range on HMM: 26-127/347.0
PMDATNVgKLEENASKNRYQNVLPRDTHRPLLISF-----STDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA
| . | | . | . |||| ..|   |. | .|         .| .  ||||.  .  . ... | || || .|| || ....  ... .| . .  |..|
pskftsv.ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdea

SSI
   
iee
subfamily_PTPRA_pd Subfamily PTPRA 269-492 2.8e-49 162.8 In-house 48-280 (330) alignment 
Range on Protein: 269-492
Range on HMM: 48-280/330.0
DATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLS--KEDASSIYW
 . .. . |||  |||. |.|| |  |  |   .   .. ||||.| .|||...| |..| |...|| || |.|.... .||||| .|   ||.    ||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

DEANPNIKQPFSMNVLDTVESEHWTERTLELK------HRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQG-GDSPVLVHCLNGVGRTGVFCV
 .          ..| |.......| | . ..      ..|..|... | | || .|      . .|.....| ...    .|. |||  |||||| |.|
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfiv

VKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
..  |.... |  ||||..|| ||    ||.|.
ldavlervkaerkvdvfefvkrlrlqrpqmvqt
subfamily_CG7180_pd Subfamily CG7180 269-492 9.6e-44 144.2 In-house 32-275 (296) alignment 
Range on Protein: 269-492
Range on HMM: 32-275/296.0
DATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA-SSIYWD
.    |  .||  |||. .|.| |  |..| ..  . ...||||.. ...   .. | |..|  .|| .| ||.||  ||..|.| .          || 
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywp

EANPNIKQPFSMNVLDTVESEHWTERTLELKHR------------KNTRIIQHFQFLSWKEVDSVDFY-QTLLDFMNNVTSQQGGD------SPVLVHCL
.   .  ... .... . .  . . ||. |...             .|||...||.  |.  |.| .  ..|..... | . ..        .||.|.. 
nkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvss

NGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
.|..|.||.. . ..|...| |. ||||. || ||..  |....
dGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 270-492 2.5e-47 156.6 In-house 39-273 (325) alignment 
Range on Protein: 270-492
Range on HMM: 39-273/325.0
ATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKED-ASSIYWDE
| .|  . || .|||..||.. |  |. | .   |.|. ||||.. . .|...  ...|.||..|. |. ||..|.| | .|.|| | ...   ..|| .
akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpk

ANPNIKQPFSMNV-LDTV-ESEHWTERTLELKHRKN--TRIIQHFQFLSWKEVDSVDFYQTLLDF-------MNNVTSQQGGDSPVLVHCLNGVGRTGVF
   . |.  ...| | |. |   .  | |..|  |.  || .. ||. ||...    .  ||. .        . ||..  . .|.|||| .||||||||
emgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvf

CVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
  .   |...  |  ||.|. || ||.|  .|...
islysalakvieesrvdifgfvkklrkdrpsmvet
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 270-492 9.6e-40 131.3 In-house 11-249 (270) alignment 
Range on Protein: 270-492
Range on HMM: 11-249/270.0
ATNVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDRE-KIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYW
 ... .   ..  |||...||  . |  | . ..|  |.|||| . .|..... | |... ||  |...|.|.|.. . ..|||. .|  .  .  . ||
esdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYW

DEANPN-IKQPF-SMNVLDTV--ESEHWTERTLELKHRKNTRIIQHFQFLSWKE------VDSVDFYQTLLDFMNNV--TSQQG-GDSPVLVHCLNGVGR
 . . . .|  .  ..|| .    .| .  . |.|... ..| . ||.. .| .       ||.   . ||  ...|  ....    .|.|||| .||||
paepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

TGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
||.. .. ...  || .  ||| .|...||.|  ...| 
tGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqh
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 272-492 2.5e-55 182.7 In-house 44-269 (297) alignment 
Range on Protein: 272-492
Range on HMM: 44-269/297.0
NVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDreKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAS-SIYWDEAN
 | .   | .|.||.|.|| |. |  | .  .| .  |.|| | .|.|   ..||||||  .|| || ....|...||||||||....| .   || .  
tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkg

PNIKQPFSMNVLDTVESEHWTERTLELKHRK--NTRIIQHFQFLSWK--EVDSVDFYQTLLDFMNNVTSQQG--GDSPVLVHCLNGVGRTGVFCVVKMCL
 .     |. .| . | |   .|.||... |  ..|... .||..|   .|.  |  ..||.....|  . .   ..|.|||||.|||||||.. .. ..
vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

DQLEVEDAVDVFQIVKALRHDNFQMIQS
 . . |..||.|..|| ||..  ...| 
aeakrekevdifglvkklrqerpylvqt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 272-492 5.7e-54 177.9 In-house 2-227 (250) alignment 
Range on Protein: 272-492
Range on HMM: 2-227/250.0
NVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA-SSIYWDEAN
.|.|  .|  |||| .... |  | .| . ..|  . ||||.| .||..|.  |.|| ||..|. || |..... ..|||||..|. ..   . ||   .
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvek

PNIKQPFSMNVLDTVESEHWTERTLELKHRKNT--RIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTS--QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQ
...     ...|.. |   .| |.| | ..|..  ||.....|..| .    . ... |.....| .  || |..||.|.| .||||.| |....  |..
aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

LEVEDAVDVFQIVKALRHDNFQMIQS
|. |  ||||...|.||.|  ....|
lkkekvvdvfkvikvlrkdrphaves
0040439 (Phosphotyrosine protein) phosphatases II 272-492 2.3e-53 176.7 In-house 4-231 (249) alignment 
Range on Protein: 272-492
Range on HMM: 4-231/249.0
NVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEA
.|..|.|| .||||...|| | .|. | ...    . |||| .  ||.   ..| || ||..|| ||.|......|..||||..|          ||.. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

NPNIKQPFSMNVLDTVESEHWTERTLELK--HRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQG---GDSPVLVHCLNGVGRTGVFCVVKMCL
..     |. ..|.. .....| |||||.    ...| ..|.|...| . .  .. ..||||.. | . .     ..|||||| .||||||.|..  ..|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

DQLEVEDAVDVFQIVKALRHDNFQMIQS
.||| |  ||....|| ||.  ....|.
eqlekelgvdleeavkllrsqRpgavqn
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 272-492 4.6e-50 165.3 In-house 42-264 (315) alignment 
Range on Protein: 272-492
Range on HMM: 42-264/315.0
NVGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDASS--IYWDEA
.| |  ||  |||| |... |  |. |    .|  ..|.||.| .||. ... |..| |. ..| || ||.... |..||||..| ... .    || . 
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

nPNIKQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQG-GDSPVLVHCLNGVGRTGVFCVVKMCLDQLE
   |  ....   .    ...| |||    ..| | .  ... || ...   .  .|.... .|   .    ....||| .|||||| |. ..  |||.|
.kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqae

VEDAVDVFQIVKALRHDNFQMIQS
.|.|.||..... .|.   .|.|.
aenaidvynfitgvrqnrikmvqv
0037934 (Phosphotyrosine protein) phosphatases II 272-492 5e-47 155.9 In-house 3-227 (243) alignment 
Range on Protein: 272-492
Range on HMM: 3-227/243.0
NVGKLEENASKNRYQNVLPRDTHRPLLisfstDTsTQYINATFCQGYKdreKIITTQMPLSQTVTD----FLRLIYDYRISTIVMLNDLS--KEDASSIY
....|.|| |||||...|| |  |  |     .  . |||| ......   ..| ||.||..|| |    |.|......|..||||..|   .      |
siallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WDeaNPNIKQPFSMNVLDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTS---------QQGGDSPVLVHCLNGVGR
|   ..    .|. ..|.. . ...| |||.|..    . || ..|...|.| . .  |  . ||||.. |..         .  ...||||||  ||||
wp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGVFCVVKMCLDQLeveDaVDVFQIVKALRHDNFQ-MIQS
||....  ..|..|   . ||....|| ||   .. ..|.
tGtliaaylmllll...g.vdleeavkllreqRpgkavqt
0049772 (Phosphotyrosine protein) phosphatases II 272-490 1e-31 106.2 In-house 39-263 (314) alignment 
Range on Protein: 272-490
Range on HMM: 39-263/314.0
NVGKLEENASKNRYQNVLPRDtHRPLLiSFSTDTSTQYINATFCQGYkdrEKIITTQMPLSQTVTDF----------LRLI--YDYRISTIVM-------
 |..|..| .||||...|| | .|  | ..    .. |||| .  |.    | | || ||. || ||          .|..  .|... .|||       
lvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LNDLSKEDassiywdeanpnikqpfsmN------VLDTVesehwtERTLELKHRKNT-RIIQHFQFLSwKEVDSVDFYQTLLDFMN
              |..|.                      |      . .        |.. . .. ...     .. .    .... .... .|.|..
delsrLdaAlgKtpllildgng...................neptaadlellk......eelydpelferlgikylripvpD.gsaplledfdeflefie

NVtsqqGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVeDAVDVFQIVKALRH--DNFQMI
..      ..||||||  |.||||.|.|. ... .| | .. .... |.. |.   |. .|
ea....dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfi
0042113 (Phosphotyrosine protein) phosphatases II 273-492 1.1e-51 170.9 In-house 3-228 (245) alignment 
Range on Protein: 273-492
Range on HMM: 3-228/245.0
VGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEAN
|..|.|| .|||| ..|| |  |  | . ..|  . |||| .  ||.  .|.| || ||..|| ||.|......|.|||||...   .   .  || . .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

PNIKQPFSMNVLDTVESEHWTERTLELK--HRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQG--GDSPVLVHCLNGVGRTGVFCVVKMCLDQ
.     |....|..   ...| ||||..    . .| ..|...|.| . .  |  ..||||.. | ...   .. ||||||  ||||||.|... ..|.|
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

LEVEDAVDVFQIVKALRHDNFQMIQS
|| |  |.....|| ||    ...|.
lekelgvsleeavkelrsqRpgavqt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 273-492 2.6e-45 149.5 In-house 37-261 (515) alignment 
Range on Protein: 273-492
Range on HMM: 37-261/515.0
VGKLEENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAS--SIYWDEAN
| . | | .||||.|.|| |. |  |     .    |.||.. ....     |..|.|.  .| || ||.......||.|...|...| .  . || .  
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

PNIK--QPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGG-DSPVLVHCLNGVGRTGVFCVVKMCLDQL
 .      ...... .      . |.|.. . ...| .  |.|  | .  .    ..|| .. .| ...|    |...||. |||||||.. .. .. . 
gdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

EVEDAVDVFQIVKALRHDNFQMIQS
.  ..||||..|. .| .  ...| 
kttrmvdvfnfvtnirqkrpylvqt
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 273-490 1.8e-15 51.9 In-house 13-242 (290) alignment 
Range on Protein: 273-490
Range on HMM: 13-242/290.0
VGKLEENASKNRYQNVLPRDThRPLLISFSTDTSTQYINATFCQgYKDREKIITTQMPLSQT-------VTDFLRLIYDYRISTIVMLNDLSKEDAS---
   ..... ..|... |  .| |  |  . .  . .|| | . . . .  ..| || |. ..       . .|. .. . ..  .||| . ....|    
tdyvkkhemdqRlevpLveat.rvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl

---SIYWDEA-NPNIK-QPFSMNVLDTVESEHWTERTLELKHRKNTR-IIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQggdSPVLVHCLNGVGRTGV
   . |  |. . ..| . ....  . .. .   .|.|..|. ..    ..| .. .|...   .  .|||. ...|  ..   .||.||| .|. |  .
faCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkask...tpvivHcvdGiSrsAa

FCVVKMCLDQLE-VEDAVDVFQIVKALRHDNFQMI
.  ...    .   ...| . ...||||.   ..|
laaiilgyQkiaetsgsvkledvlkalrkqralai
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 273-371 1.4e-09 32.2 In-house 41-155 (350) alignment 
Range on Protein: 273-371
Range on HMM: 41-155/350.0
VGKLEENASKNRYQNVLPRDTHRPLLI---------SFSTDTsTQYINATFCQGY------KDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLS
. .  |  .||||.|.|| .  |  |            |. |   |||| . .        .   | | || || .|| || ..|.   .  |..|... 
lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslst.nDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdv

KEDA--SSIYWDEANP
  .     .||.| . 
elnlekcyrYWqegsy
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 274-357 2.8e-08 27.8 In-house 42-118 (303) alignment 
Range on Protein: 274-357
Range on HMM: 42-118/303.0
GKLEENASKNRYQNVLPRDTHRPLLisfsTDTStqYINATFCQgYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLS
 .. .|  |||. .|.  |  .  |    .|.|  || |.. .  . . | | ||.|||.| .|| ..| . ..  ...|   |
nqfvknmdknrfvdvicldhskvkl....sdss..yihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltds
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 275-492 1.1e-14 49.1 In-house 31-255 (285) alignment 
Range on Protein: 275-492
Range on HMM: 31-255/285.0
KLEENASKNRYQNVLPRDTHRPLLISFSTDtstqYINATFCQ-GYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANP
  | |   ||| .|   .  | .|  .  |    || |.. .   ||.   |||| || .|..|| ..||. .|. ..||  | .   .  ..|. |   
ayeanpdlnryadvrcieetrvvlknhdrd....yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

NIKQPFSMNV-LDTVESEH-----WTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMC
.. .    .. |  .. |      .   |.        .   ..| |   | .  . .  . .... . |   .  . |. |||  |||||  |  .  .
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidya

LDQLEVEDAVDVFQIVKALRHDNFQMIQS
  ..  .  .....||. .|   || .||
tirimenpniemldivremramrfqavqs
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 275-319 4.5e-06 20.5 In-house 35-78 (244) alignment 
Range on Protein: 275-319
Range on HMM: 35-78/244.0
KLEENASKNRYQNVLPRDTHRPLLiSFSTDTSTQYINATFCQGYK
 |  ||.|||| |.|| |  | .| | |   ...|||| . || .
vlsanatknryinilpfdetrvil.ssskkegsdyinanyiqgsq
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 277-492 2.4e-26 87.4 In-house 6-226 (239) alignment 
Range on Protein: 277-492
Range on HMM: 6-226/239.0
EENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREK-IITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNI
  | .|||| |..  |  | .|  .| |  ..||||.. . |    |  |.||  .. .  || |.... |   ||||  | .        || ..  . 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

KQpFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQ-QGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVE
 . . . .  |     .  ||. . .  . . | . ...|  | .    ..  ..| .  ..| .   |  | ..||  |||||| | |.   | | . .
cn.lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

DAVDVFQIVKALRHDNFQMIQS
 .||.|. |||.| |  .|.|.
ktvdifnyvkairedrphmvqt
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 277-366 1.6e-11 38.3 In-house 50-140 (310) alignment 
Range on Protein: 277-366
Range on HMM: 50-140/310.0
EENASKNRYQNVLPRDTHRPLLiSFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDASS--IYW
...  |||| .|. .|| |  |         .|| | . .    |. .| .| || .|. || |.|.. |  .|..|   ..|       ||
kkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 278-491 2.6e-28 93.8 In-house 2-223 (237) alignment 
Range on Protein: 278-491
Range on HMM: 2-223/237.0
ENASKNRYQNVLPRDTHRPLLISFSTDtsTQYINATFCQGYKDRE-KIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEAN-PNI
||  |||| |.   |  | .|    ..  ..|||||. .|.     | |..| ||  .  || ..... . | ||||  | .        || ... |. 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

KQPFSMNVLDTVESEHWTERTLELKHR---KNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGG---DSPVLVHCLNGVGRTGVFCVVKMCLDQL
   ... .    |   .| |.| | .|   |. |.|. .|| || .    .   .|| |  |.  .       .| ..||  ||||||.| |.   | | 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

EVEDAVDVFQIVKALRHDNFQMIQ
. .  ||... |...  |   .||
kekkvvdiynyvysieedrpyiiq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 278-492 2.7e-26 87.2 In-house 6-225 (239) alignment 
Range on Protein: 278-492
Range on HMM: 6-225/239.0
ENASKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDREK-IITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIK
 | .|||| |..  |  | .|  .| |  ..||||.. . |    |  |.||  .. .  || |.... |   ||||  | .        || ..  .  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

QpFSMNVLDTVESEHWTERTLELKH--RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQ-QGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVED
. . . .  |     .  ||. . .  . . | . ...|  | .    ..  ..| .  ..| .   |  | ..||  |||||| | |.   | | . . 
n.lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

AVDVFQIVKALRHDNFQMIQS
.||.|. |||.| |  .|.|.
tvdifnyvkairedrphmvqt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 278-417 2.1e-17 57.9 In-house 32-177 (297) alignment 
Range on Protein: 278-417
Range on HMM: 32-177/297.0
ENASKNRYQNVLPRDTHRPLLISFStdTSTQYINATFCQGYKDR--EKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNI
    ||||...|  |. |  |      | ..|||| .    ..    | | .| |||.|| || .|...  . .|||.  | ..       || ... . 
sslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

KQPFSM------NVLDTVESEHWTErtLELKHRKNTRIIQHFQFLSWKEV
..  ..      .. |  .  . ||  |.| .|...| ..| ||||| . 
lkagdvvveflsstsdefdrvilte..lqliyrsesrvvrhvqflswpdh
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 278-372 5e-07 23.4 In-house 47-159 (349) alignment 
Range on Protein: 278-372
Range on HMM: 47-159/349.0
ENASKNRYQNVLPRDTHRPLL---------ISFSTDTS-----TQYINATFCQ--GYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDA
|  .||||...|| .  |  |         |  || .|      .|||| . .   ..  .| |.||.||  || ||...|   ..  .. |||  ... 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

SS--IYWDEANPN
    |||.| . .
ekcdiywqelsys
Y_phosphatase Protein-tyrosine phosphatase 279-492 1.5e-55 183.6 Pfam-A 1-222 (235) alignment 
Range on Protein: 279-492
Range on HMM: 1-222/235.0
NASKNRYQNVLPRDTHRPLLisfS-TDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWD--EANPNI
| .||||...|| |  |  |   . ......|||| . .|||. .|.| ||.||..|. || |.........||||..| ..   . . ||.  | ... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

KQPFSMNVL-DTV-ESEHWTERTLELKHRKNT---RIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQ-GGDSPVLVHCLNGVGRTGVFCVVKMCLDQL
 . .....  ..  .....| |.||||..|.    |....... .|.. .  . .. |||....| ...   ..||.||| .||||||.|......|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

EVEDAVDVFQIVKALRHDNFQMIQS
| |. |||.|||| ||.  ..|.||
eaeeevdvlqivkelRkqRpgmvqs
Y_phosphatase Protein-tyrosine phosphatase 279-492 1.5e-55 183.6 In-house 1-222 (235) alignment 
Range on Protein: 279-492
Range on HMM: 1-222/235.0
NASKNRYQNVLPRDTHRPLLisfS-TDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWD--EANPNI
| .||||...|| |  |  |   . ......|||| . .|||. .|.| ||.||..|. || |.........||||..| ..   . . ||.  | ... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

KQPFSMNVL-DTV-ESEHWTERTLELKHRKNT---RIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQ-GGDSPVLVHCLNGVGRTGVFCVVKMCLDQL
 . .....  ..  .....| |.||||..|.    |....... .|.. .  . .. |||....| ...   ..||.||| .||||||.|......|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

EVEDAVDVFQIVKALRHDNFQMIQS
| |. |||.|||| ||.  ..|.||
eaeeevdvlqivkelRkqRpgmvqs
0041856 (Phosphotyrosine protein) phosphatases II 279-492 2.6e-33 110.5 In-house 1-156 (182) alignment 
Range on Protein: 279-492
Range on HMM: 1-156/182.0
NASKNRYQNVLPRDTHRpllisfstdtSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNdlskedaSSIYWDEANpnikqpfs
| .||||...|| |  |             |||| .  |.    ..| || || .|| ||||......|.|||.|.       .  || |          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.......eelywpell........

mnvldtvesehwtertlelkhrknTRIIQHFQFLSWKEVDSVDfYQTLLDFMNNVTSqqgGDSPVLVHCLNGVGRTGVFCVVKMCLDQlevedAVDVFQI
                        .| . ....|.|   .  |  ..||||.. | .    . ||||||  ||||||....  ... .      |.....
........................erlgiqylylpwpDhgvpd.ldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleea

VKALRHDNFQMIQS
|| .|   ..|...
vklvrsrRpgmvit
subfamily_CG42327_pd Subfamily CG42327 281-420 2.3e-13 44.5 In-house 30-177 (319) alignment 
Range on Protein: 281-420
Range on HMM: 30-177/319.0
SKNRYQNVLPRDTHRPLLISFSTDTSTQYINATFCQGYKDRE-KIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEA--NPNIKQ
 |.|. ||.|    |. | . . | ...|..|.. .||.| .   |..|..| .. .|| |.... .  .|| | |||.      . |.      .| . 
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

PFSMNV--LDTVESEHWTERTLELKH--RKNTRIIQHFQFlSWKEVDSV
   . |   .    ...   || ||.  ....| . |. .  | | .  
yGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevP
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 282-491 8.9e-20 65.6 In-house 53-265 (301) alignment 
Range on Protein: 282-491
Range on HMM: 53-265/301.0
KNRYQNVlPRDTHRplLISFSTDTSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLS--KEDASSIYWDEANPNIKQ--PF
|.||..| | . .    .   .|     | | . .   . .. |.|| ||..|  ||  ..  | . .||||      .|.  . |     ..  .   |
khryptv.PckPst..avevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

SMNV--LDTVESEHWTERTLELKH---RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSqqgGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDA
....   ... ... ..||||..    . .|| . |.|. .| . .    .  | |.|. |      . |..||| .|.||.  |   ..   ..| .  
kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk...sekPivvhcsaGiGrsvafigteylareveadpt

VDVFQIVKALRHDNFQMIQ
... . .| ||.. .. .|
ieltealkhlrehrwngvq
0044763 (Phosphotyrosine protein) phosphatases II 290-481 7.6e-19 63.5 In-house 1-152 (178) alignment 
Range on Protein: 290-481
Range on HMM: 1-152/178.0
PRDTHRPLLISFSTDTSTQYINATFCQGYkdreKIITTQMPlsqtvTDFLRLIYDYRISTIVMLNDLSK---EDASSIYWDEANpnikqpfsmnvldtve
| | .| ||....   ...||||..  ..     ..... |      |.|.|.... |..||.|..      ..    ...||.                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

sehwtertlelkhrkntRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGgdSPVLVHCLNGVGRTGVFCVV-KMCLDQLEVEDAVDVFQIVKA
                    .|. .  ... |. .. . ...|.... ...|  .||||||  ||||.|....   |.  .| .|.|.. .. .. 
.................iqylhipipDhgvpdllehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp
0046846 (Phosphotyrosine protein) phosphatases II 303-491 1.1e-24 82.6 In-house 8-157 (176) alignment 
Range on Protein: 303-491
Range on HMM: 8-157/176.0
TDTSTQYINATFCQGYkdreKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAS--SIYWDE-ANPNIkqpfsmnvldtvesehwtertlelkh
 | .  |||| .  |.    . |.|| || .|. |||.......|...|.|...   .      ||.|  ...|                          
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

rkntriiqHFQFLSWKEVDSVDFyQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKmcldQLEVEDAVDVFQIVKALRHDNF-QMIQ
        ....| | . .  |. . ||.... . ...  . ||||||  |.||||....       || |  ..|..... .|   . ...|
........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 305-371 1.7e-06 22.4 In-house 11-74 (130) alignment 
Range on Protein: 305-371
Range on HMM: 11-74/130.0
TSTQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAssiYWDEANP
   .|||| |        . . || ||..| .|| ... .  .  .|.|  . .||    || ...|
qgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede...ywpdseP
0043147 (Phosphotyrosine protein) phosphatases II 306-491 3.4e-28 93.9 In-house 4-145 (172) alignment 
Range on Protein: 306-491
Range on HMM: 4-145/172.0
STQYINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLskedassiywdeanpnikqpfsmnvldtvesehwtertlELKHRKNTRI
.. |||| .  .|    ..| || ||. |. ||.|..... |..||.|..|                                       ..   . .| 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.......................................lydpellerl

IQHFQFLSWKEVDSVdFYQTLLDFMNNVTS--QQGGDSPVLVHCLNGVGRTGVFCVVKMCLdqleveDAVDVFQIVKALRHDNFQMIQ
. ....|.|   .     . ||.|.. . .  ..  . ||||||  ||||||....  ..|        ......|. .|.  ....|
giqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq
0051429 (Phosphotyrosine protein) phosphatases II 307-492 3.6e-28 94.4 In-house 4-210 (272) alignment 
Range on Protein: 307-492
Range on HMM: 4-210/272.0
TQYINATFCQGYKD---REKIITTQMPLSQTVTDFLRLiYDYRISTIVMLNDLS--KEDASSIYWD------------EANPNIKQPFSMNVLDTVESEH
. |||| .  ||     . ... ...||  |. || || ....|.|||.| ...  . .  . ||             .| .     ... .| ..  ..
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

WTERTLELK---HRKNTRIIQHFQFLSWKEVDSV-DFYQTLLDFMNNvtsqqggDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVD--------VFQ
.. |.|.|.   . ...| . |.....|       . . .||.....       . ||||||  |..|||..... ..| ... |. ||        ...
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

IVKALRHDNFQMIQS
.|. ||    ...|.
aveelraqrpgavqt
0051082 (Phosphotyrosine protein) phosphatases II 307-491 5.8e-24 79.8 In-house 3-137 (151) alignment 
Range on Protein: 307-491
Range on HMM: 3-137/151.0
TQYINATFCQGYkdrekIITTQMPLSqtvtDFLRLIYDYRISTIVMLNDLSKEDASSIYWDEANpnikqpfsmnvldtvesehwtertlelkhrkntRII
. |||...  |.     .. ...||.    |||.|.... |.|||.|...   .    |. |..                                 . .
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg.................................iev

QHFQFLSWKEVDSVDFYQTLLDFMNNVTSqqGGDSPVLVHCLNGVGRTGVFCVVKMCLDQlevedaVDVFQIVKALRHDNFQMIQ
 |...|.|.. .  ......|.|.. . .   .. ||||||  |.||||..... ..| .      |....... .|  .. ..|
lhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvq
0036282 (Phosphotyrosine protein) phosphatases II 308-492 3.8e-29 97.0 In-house 3-155 (174) alignment 
Range on Protein: 308-492
Range on HMM: 3-155/174.0
QYINATFCQGYKDREKIITTQMPLSqtvtdFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEanpnikqpfsmnvldtvesehwtertlelKHRKNTRI
 ||||... ..   ...| .| ||.     |........|.|.|||...   .      || |                             ..   .| 
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredlerl

IQHFQFLSWKEVDSVDFYQtLLDFMNNVTSQQGG--DSPVLVHCLNGVGRTGVFCVVKMCLDQLEvEDAVDVFQIVKALRHDNFQMIQS
. ....| |      |. . ||.|.. | . .    . ||||||  ||||||....  ..| .|. |..||....|..||  . .|.|.
giqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 309-371 9.9e-06 19.3 In-house 124-183 (244) alignment 
Range on Protein: 309-371
Range on HMM: 124-183/244.0
YINATFCQGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKEDAssiYWDEANP
||||.|        . | || ||..|  || ... .  .  .|.|  . .||    || ...|
yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede...ywpdsep
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 316-486 1.8e-32 107.2 In-house 230-417 (440) alignment 
Range on Protein: 316-486
Range on HMM: 230-417/440.0
QGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSkEDASSIYWDEANPNI-KQPFSMNVLDTVESEHWTERTLELKHRKNTRIIQHFQFLSW
.||  .. .|.|||||  || || ||..|||||||.|||.|  . . ||||      .   ||..    . . .    ||||||....   |. |.  .|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqln.dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtw

K---EVDSV-------DFYQTLLDFMNNVT-------SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDN
    . | |       |    |.|.....        |. |   |.||||| |.  .|||| |  ||.||. . |.|||| .. ||   
ptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsr
0049260 (Phosphotyrosine protein) phosphatases II 316-491 2.2e-23 78.1 In-house 3-134 (152) alignment 
Range on Protein: 316-491
Range on HMM: 3-134/152.0
QGYKDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWdeanpnikqpfsmnvldtvesehwtertlelkhrkntriiqHFQFLS
.||.   ..| || |...|. ||.|..... |.|||||..|.  .      |.                                         ....| 
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlp

WKEVDSVDFYQTLLDFMNNVTS-QQGGDSPVLVHCLNGVGRTGVFCVVKMCLdqleveDAVDVFQIVKALRHDNFQMIQ
|      |. | ||...  .   ..  . ||||||  ||||||....  ..|        |.....|. .|  . ....
wpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavp
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 319-493 2.6e-19 64.2 In-house 2-190 (199) alignment 
Range on Protein: 319-493
Range on HMM: 2-190/199.0
KDREKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDT-VE-SEHWTERTLELK----HRKNTRIIQHFQ
| . . |.|| || .|..|| .....     |||.||  |.     ..||  ..    .  |..|    .     .|  .| |         || | |.|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FLSWKEVD--SVDFYQTLLDFMNNVTS--QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVE--DAVDVFQIVKALRHDNFQMIQSL
| ||||     | ..  ..    .|.   .|  |.||.||| .| | ||||  . . .   |      ||.|.. | ||     .| ||
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 321-493 3.6e-19 63.7 In-house 3-189 (198) alignment 
Range on Protein: 321-493
Range on HMM: 3-189/198.0
REKIITTQMPLSQTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDT-VE-SEHWTERTLELK----HRKNTRIIQHFQFL
. . |.|| || .|..|| .....     |||.||  |.     ..||  ..    .  |..|    .     .|  .| |         || | |.|| 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWKEVD--SVDFYQTLLDFMNNVTS--QQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVE--DAVDVFQIVKALRHDNFQMIQSL
||||     | ..  ..    .|.   .|  |.||.||| .| | ||||  . . .   |      ||.|.. | ||     .| ||
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl
subfamily_hpo-7_pd Subfamily hpo-7 324-465 8.1e-11 36.3 In-house 42-179 (263) alignment 
Range on Protein: 324-465
Range on HMM: 42-179/263.0
IittqmpLSQTVTDFLRLIYDYRISTIVMLNDLSKE--DASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLELKH----RKNTRIIQHFQFLSWKEV
.      | ||.  |.. |   . ...||| |   |  .  | |.     . ..   .||  |   .    .||||      .|.|. ..|...  | |.
l......lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiek

DSVDFYQTLLDFMNNVTSQqggdSPVLVHCLNGVGRTGVFCVVKMCLD
  .   .  |  .. ..       .. ||| .|.||.  | |. .   
ndpelareilnilkvarns....kslvvhcstGiGrsaafsvaElvyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 329-465 7.8e-12 39.8 In-house 39-173 (255) alignment 
Range on Protein: 329-465
Range on HMM: 39-173/255.0
MplsqTVTDFLRLIYDYRISTIVMLNDLSKED--ASSIYWDEANPNIKQPFSMNVLDTVESEHWTERTLEL----KHRKNTRIIQHFQFLSWKEVDSVDF
.    ||  |.. |   . ...||| |.  |.    | |.     . ..   .||  |  | .   ||||.     ..|.|. ..|...  | |  . . 
l....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel

YQTLLDFMNNVTSQqggdSPVLVHCLNGVGRTGVFCVVKMCLD
 . .|  .  |.       .|.||| .|.||.  | .. .   
areilnilkvvrds....ksvvvhCstGiGrsaafvlaelvyq
subfamily_DSP12_pd Subfamily DSP12 382-482 2.8e-07 25.0 In-house 31-125 (155) alignment 
Range on Protein: 382-482
Range on HMM: 31-125/155.0
LDTVESEHWtertLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQqggDSPVLVHCLNGVGRTGVFCVVK-MCLDQLEVEDAVDVFQIVK
. .| .|.      | |..|..   .. | |   |.| ...... .||...  ..   .  |||||  || |   ...   |  ..|..|.|... . .|
vlsvikeel....pehklkkgkvstkfiqilDepeediLshldeavdFieealee...egavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekk

AL
  
pe
PTPc_motif_SM00404 388-490 1.3e-08 29.8 In-house 38-131 (140) alignment 
Range on Protein: 388-490
Range on HMM: 38-131/140.0
EHWTertlelKHRKNTRIIQHFqFLSWKEVDSVDFYQTLLDFMNNVTSQQGgdsPVLVHCLNGVGRTGVFCVV-KMCLDQLEVEDAVDVFQIVKALRHDN
  .|      |. .. .|.|       .. . ... . .|||..|.....|    |||||  || |.. ....  |. .||....|.....  .     |
vslt......kensgfqilqip.lddnekdklskyldkvldfienaekkgg...kvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispn

FQMI
.. .
lnfv
0038934 (Phosphotyrosine protein) phosphatases II 392-480 1.2e-09 33.6 In-house 67-156 (194) alignment 
Range on Protein: 392-480
Range on HMM: 67-156/194.0
ERTLELKHRKN-TRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQqGGDSPVLVHCLNGVGRTGVFCVVKMCL-DQLEVEDAVDVFQIVK
||. . .. ..    . ...| .  .| | . ... ||... ....   .  |.|||  |.||||....  .    .. .|.|.. |....
eryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR
subfamily_DSP11_pd Subfamily DSP11 392-480 3.5e-06 21.0 In-house 67-157 (178) alignment 
Range on Protein: 392-480
Range on HMM: 67-157/178.0
ERTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTS-QQGGDSPVLVHCLNGVGRTGV-FCVVKMCLDQLEVEDAVDVFQIVK
.|  . |. ... .  .  . . .||.. . .... ..... .  ..  |. . ||| .|| |||   |   .  ...| |||...|. ..
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear
0048076 (Phosphotyrosine protein) phosphatases II 393-491 5.3e-16 54.1 In-house 34-127 (145) alignment 
Range on Protein: 393-491
Range on HMM: 34-127/145.0
RTLELKHRKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDqlevEDaVDVFQIVKALRHDNFQMIQ
 .|    .  .| . ....|.|   .  |....||.|.. . . .  . ||||||  ||||||....  ..|     .. |....... .|   .....
lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavp
0048179 (Phosphotyrosine protein) phosphatases II 394-491 6.2e-16 53.9 In-house 22-129 (144) alignment 
Range on Protein: 394-491
Range on HMM: 22-129/144.0
TLELKHRKNTRI---------------IQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLdqleVEDaVDVFQI
  .||. . | .               . ....|.|   .  |... ||.|.. . . .  . ||||||  ||||||....  ...    ... ......
lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleea

VKALRHDNFQMIQ
.. .|  ......
lalvrsrrpgavp
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 394-491 3.7e-08 27.2 In-house 174-272 (302) alignment 
Range on Protein: 394-491
Range on HMM: 174-272/302.0
TLELKH----RKNTRIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQggdSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQM
|.|.|     .|  . .. ..| .| .  . .  .| || ..   | .     ||||| .|||||| .  .|  ..    ..  |. .||. .|.  .  
tveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGa

IQ
.|
vq
subfamily_DSP15_pd Subfamily DSP15 401-488 1.7e-06 22.2 In-house 37-127 (151) alignment 
Range on Protein: 401-488
Range on HMM: 37-127/151.0
KNTRIIQH--FQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVK-MCLDQLEVEDAVDVFQIVKALRHDNFQ
 . .....  ..... ..  |... . . . .. . . .  .  |||||| || |    .|.  |   .|. .||..| .  ... . || 
nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfG
DSPc Dual specificity phosphatase, catalytic domain 402-491 4.1e-08 28.2 Pfam-A 36-125 (133) alignment 
Range on Protein: 402-491
Range on HMM: 36-125/133.0
NTRIIQHFQFL--SWKEVDSVDFYQTLLDFMNNVtsqQGGDSPVLVHCLNGVGRTGVFCVV-KMCLDQLEVEDAVDVFQIVKALRHDNFQMIQ
..  |....      .| . ... . . .|....   .     |||||  |. |.. ....  |. ..|....|.....  .     |.. ..
kkseieylripvedetetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflr
DSPc Dual specificity phosphatase, catalytic domain 402-491 4.1e-08 28.2 In-house 36-125 (133) alignment 
Range on Protein: 402-491
Range on HMM: 36-125/133.0
NTRIIQHFQFL--SWKEVDSVDFYQTLLDFMNNVtsqQGGDSPVLVHCLNGVGRTGVFCVV-KMCLDQLEVEDAVDVFQIVKALRHDNFQMIQ
..  |....      .| . ... . . .|....   .     |||||  |. |.. ....  |. ..|....|.....  .     |.. ..
kkseieylripvedetetkiskeleeavefieka...eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflr
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 404-491 1e-06 22.7 In-house 176-260 (312) alignment 
Range on Protein: 404-491
Range on HMM: 176-260/312.0
RIIQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQggdSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQ
  ..|.|. || .    |  .| | ..  |  ..    ||. ||  |||||| .....  .  |      .| ..   ||.|  . ..
sklnhyqwaswpdhgmpdscdtalrllsavkkdk...kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvr
PTPc_DSPc_SM00012 406-492 2.7e-21 71.1 In-house 2-92 (105) alignment 
Range on Protein: 406-492
Range on HMM: 2-92/105.0
IQHFQFLSWKEVDSVDFYQTLLDFMNNVTSQQGGD---SPVLVHCLNGVGRTGVFCVVKMCLDQLEVE-DAVDVFQIVKALRHDNFQMIQS
..|.....|..    .  . .|.....| ...      .||.||| .||||||.|... ..|.||| | . ||.|||||.||.   .|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqt
subfamily_DSP19_pd Subfamily DSP19 410-481 3.7e-06 21.4 In-house 62-128 (152) alignment 
Range on Protein: 410-481
Range on HMM: 62-128/152.0
QFLSWKEVDSVDFYQTLLDFMNNVTSQQggdSPVLVHCLNGVGRTGVFCVVKMcLDQLEvEDAVDVFQIVKA
. |  .| | ...... |||.... |..     |||||  || |.  . .  . . . |  .  . .. |..
eilDlpetdllsylkealdFieearskd...gavlvHCnAGvSRsasvviayl.mkkee.lsleealelvre
subfamily_DSP6_pd Subfamily DSP6 416-493 8.1e-06 19.4 In-house 69-147 (158) alignment 
Range on Protein: 416-493
Range on HMM: 69-147/158.0
EVDSVDFYQTLLDFMNNVTSQQGGDSPVLVHCLNGVGRTGVFCVV-KMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSL
.. | .. . . . .. .   .  .| |||||| |. |.   ..   |   .| ..|| |. .  |.    ||.... |
dhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgql
subfamily_DSP1_pd Subfamily DSP1 418-493 4.3e-07 24.2 In-house 76-149 (163) alignment 
Range on Protein: 418-493
Range on HMM: 76-149/163.0
DSVDFYQTLLDFMNNVTSQQGgdsPVLVHCLNGVGRTGVFCVVK-MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSL
|    ... ..|...|....|    ||.||  |. |   .|..  |  .....|.| |  . .... . |.  ...|
dislvfeeviefidevkkknG...kvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqL
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 425-471 9.3e-07 22.5 In-house 249-296 (349) alignment 
Range on Protein: 425-471
Range on HMM: 249-296/349.0
TLLDFMNN-VTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVED
 |.| ..     ..   |..||||  | |||||.. . . |. ||   
dliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 430-469 2.8e-07 24.6 In-house 252-291 (350) alignment 
Range on Protein: 430-469
Range on HMM: 252-291/350.0
MNNVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEV
. .  ...   ||.||||  ||||||... . . | ..|.
faeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfei
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 432-493 1.1e-06 22.7 In-house 220-281 (297) alignment 
Range on Protein: 432-493
Range on HMM: 220-281/297.0
NVTSQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQSL
 . ...  . ..||||  ||||.||    .. |..|  .   ||  |.. ||.   ...|.|
slraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtl
subfamily_CG42327_pd Subfamily CG42327 435-492 1e-09 32.5 In-house 242-300 (319) alignment 
Range on Protein: 435-492
Range on HMM: 242-300/319.0
SQQGGDSPVLVHCLNGVGRTGVFCVVKMCLDQLEVE-DAVDVFQIVKALRHDNFQMIQS
...    |. ||| .||||||.     . . .||    .||. |.|  .|.|  . ...
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavlt
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 440-492 1.5e-06 22.0 In-house 223-275 (310) alignment 
Range on Protein: 440-492
Range on HMM: 223-275/310.0
DSPVLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
  |..|||  |..|..| . .|. .|.|.  . ||. ...  |...... ||.
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 443-492 2.3e-15 50.9 In-house 321-370 (392) alignment 
Range on Protein: 443-492
Range on HMM: 321-370/392.0
VLVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHDNFQMIQS
.||||| | |||||||    |. |.   |.||.|| || || | .|..|.
ilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqt
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 444-484 6.3e-06 20.5 In-house 2-42 (69) alignment 
Range on Protein: 444-484
Range on HMM: 2-42/69.0
LVHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRH
.|||  | |||| |  . . . ..  |  ||.|  |. .| 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 445-485 8.3e-06 20.1 In-house 2-42 (69) alignment 
Range on Protein: 445-485
Range on HMM: 2-42/69.0
VHCLNGVGRTGVFCVVKMCLDQLEVEDAVDVFQIVKALRHD
|||  | |||| |  . . . ..  |  ||.|  |. .|  
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkc