Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
Y_phosphatase | Protein-tyrosine phosphatase | 1-42 | 4.2e-09 | 31.5 | Pfam-A | 192-233 (235) | alignment | ||
Range on Protein: 1-42
Range on HMM: 192-233/235.0
MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
..|.||| |. |||.|||| ||. ..|.|||| |. .|...
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 1-42 | 4.2e-09 | 31.5 | In-house | 192-233 (235) | alignment | ||
Range on Protein: 1-42
Range on HMM: 192-233/235.0
MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
..|.||| |. |||.|||| ||. ..|.|||| |. .|...
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
|
|||||||||
DSPc_SM00195 | 1-46 | 1.5e-08 | 29.7 | In-house | 217-262 (263) | alignment | |||
Range on Protein: 1-46
Range on HMM: 217-262/263.0
MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
..|..|| |. ||.|.|||.||. ..|.|.|| |. .|... ...
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
PTPc_SM00194 | 1-46 | 1.5e-08 | 29.7 | In-house | 217-262 (263) | alignment | |||
Range on Protein: 1-46
Range on HMM: 217-262/263.0
MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
..|..|| |. ||.|.|||.||. ..|.|.|| |. .|... ...
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
0050432 | (Phosphotyrosine protein) phosphatases II | 1-46 | 3.6e-08 | 28.6 | In-house | 254-299 (308) | alignment | ||
Range on Protein: 1-46
Range on HMM: 254-299/308.0
MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
..|.||| | ||||..|| ||. .|.|..| |...||.| ...
llleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 1-45 | 9e-08 | 27.4 | In-house | 241-285 (288) | alignment | ||
Range on Protein: 1-45
Range on HMM: 241-285/288.0
MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
..|.||| | |||...|| ||. ..|.|..| |...|..| ..
llleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 1-46 | 1.2e-07 | 26.9 | In-house | 226-274 (284) | alignment | ||
Range on Protein: 1-46
Range on HMM: 226-274/284.0
MCLDQLEVED---AVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
..|.||| |. |||...|| || ..|.|.|| |...|..| ...
llleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
|
|||||||||
PTPc_DSPc_SM00012 | 1-43 | 2.7e-07 | 26.1 | In-house | 61-104 (105) | alignment | |||
Range on Protein: 1-43
Range on HMM: 61-104/105.0
MCLDQLEVE-DAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILN
..|.||| | . ||.|||||.||. .|.|..|.| .||.|.
illqqleketkevdifqivkelrkqRpgmvqteeqylflyrall
|
|||||||||
subfamily_PTPN9_pd | Subfamily PTPN9 | 1-42 | 7.7e-07 | 23.4 | In-house | 245-286 (297) | alignment | ||
Range on Protein: 1-42
Range on HMM: 245-286/297.0
MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
.||..|| .. |||.. || || .|| | |..|| .
iclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 1-44 | 9.2e-07 | 24.1 | In-house | 227-270 (273) | alignment | ||
Range on Protein: 1-44
Range on HMM: 227-270/273.0
MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNH
..||||| | |||...|| || . |.|..| |...|..| .
llldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 1-45 | 1.1e-06 | 23.6 | In-house | 229-276 (297) | alignment | ||
Range on Protein: 1-45
Range on HMM: 229-276/297.0
MCLDQLE---VEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
..|.||| | ||....|| ||. ....|.|| |. .|..| .|
lmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 1-46 | 3.4e-06 | 22.0 | In-house | 231-276 (317) | alignment | ||
Range on Protein: 1-46
Range on HMM: 231-276/317.0
MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
..|.||| | |||...|| ||. ...|..| |. .|..|....
lmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
|
|||||||||
subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 1-46 | 7.3e-06 | 20.2 | In-house | 233-278 (287) | alignment | ||
Range on Protein: 1-46
Range on HMM: 233-278/287.0
MCLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
. ... . | ..||||..| | ...| | || . |. . .
ttinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 2-56 | 1.4e-10 | 35.8 | In-house | 239-293 (305) | alignment | ||
Range on Protein: 2-56
Range on HMM: 239-293/305.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQENTLQS
|..|. |. ||||...|.||. .|.|.|. | .. .|. |. . . . |
alerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigs
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 2-47 | 2.7e-10 | 34.4 | In-house | 246-291 (296) | alignment | ||
Range on Protein: 2-47
Range on HMM: 246-291/296.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMA
.|...| |. ||||. || ||.. |.... |.|| .| .|.. .
nlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 2-54 | 4e-10 | 34.0 | In-house | 237-289 (564) | alignment | ||
Range on Protein: 2-54
Range on HMM: 237-289/564.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQENTL
.|.... |. ||..|.|||||.. |.|. | | ....... .|. ...
mlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteve
|
|||||||||
subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 2-46 | 1.6e-09 | 32.1 | In-house | 235-279 (315) | alignment | ||
Range on Protein: 2-46
Range on HMM: 235-279/315.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
|||.|.|.|.||..... .|. .|.|..| |.. | .| .
vldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
|
|||||||||
subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 2-58 | 2.2e-09 | 31.8 | In-house | 239-296 (319) | alignment | ||
Range on Protein: 2-58
Range on HMM: 239-296/319.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQ-ENTLQSTQ
|.... | ..|||..|. || |.| | ||..| .| . . . . | .| .
mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlr
|
|||||||||
subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 2-50 | 3.8e-09 | 30.7 | In-house | 249-297 (301) | alignment | ||
Range on Protein: 2-50
Range on HMM: 249-297/301.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQ
|.| | |||||..||.|. ... || | | ... ... .
glEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
|
|||||||||
subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 2-54 | 5.2e-09 | 30.6 | In-house | 240-291 (297) | alignment | ||
Range on Protein: 2-54
Range on HMM: 240-291/297.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMaMSQENTL
.. . . |..||.|..|| ||.. ...| |.||. | ... . .|.. .
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal.lsedtri
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 2-45 | 8.5e-09 | 29.2 | In-house | 394-437 (440) | alignment | ||
Range on Protein: 2-45
Range on HMM: 394-437/440.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
||.||. . |.|||| .. || ... .| || |||..| |
cleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykllthh
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 2-61 | 1.2e-08 | 29.2 | In-house | 233-290 (315) | alignment | ||
Range on Protein: 2-61
Range on HMM: 233-290/315.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMamSQENTLQSTQEFD
...|.. ...||||..|| || . ...|. |.| . | .. . ||| |
vvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl..lwrntlilvihft
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 2-48 | 1.6e-08 | 29.0 | In-house | 235-281 (288) | alignment | ||
Range on Protein: 2-48
Range on HMM: 235-281/288.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAM
.|..| || .||. .|. ||. ....| |. | .|..| .|.
lidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
|
|||||||||
subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 2-44 | 6e-08 | 26.5 | In-house | 341-383 (392) | alignment | ||
Range on Protein: 2-44
Range on HMM: 341-383/392.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNH
|. |. |.||.|| || || | .|..|. |.| . | . .
ciaqiaegdsvdifqtvkilradrmqfvqteeeyafvydvire
|
|||||||||
subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 2-45 | 5.3e-07 | 24.0 | In-house | 224-267 (274) | alignment | ||
Range on Protein: 2-45
Range on HMM: 224-267/274.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
.. ||. | |||..|| || | |.|. | |.| .|.| .
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
|
|||||||||
subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 2-44 | 8.6e-07 | 23.1 | In-house | 239-281 (290) | alignment | ||
Range on Protein: 2-44
Range on HMM: 239-281/290.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNH
... . | .||||..| .| ...|. . |.. ..|. .
tinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
|
|||||||||
subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 2-46 | 4.6e-06 | 20.8 | In-house | 220-264 (270) | alignment | ||
Range on Protein: 2-46
Range on HMM: 220-264/270.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
.. || . ||| .|...||.| ...| | |.. |. . . .
avrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
|
|||||||||
subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 2-69 | 8.7e-06 | 19.4 | In-house | 235-300 (439) | alignment | ||
Range on Protein: 2-69
Range on HMM: 235-300/439.0
CLDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMamSQENTLQSTQEFDMEKDDGLS
.|.|| .|. ||. ||| ||.. ||.|.| .| . | . . .. . .|| | . |.|
aleqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi..vyGdiavtidefkkefnagfs
|
|||||||||
subfamily_PTPRA_pd | Subfamily PTPRA | 3-46 | 6.1e-10 | 33.5 | In-house | 252-295 (330) | alignment | ||
Range on Protein: 3-46
Range on HMM: 252-295/330.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLM
|.... | ||||..|| || ||.|..| |...|..| .
lervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 3-47 | 6.8e-10 | 33.7 | In-house | 247-291 (298) | alignment | ||
Range on Protein: 3-47
Range on HMM: 247-291/298.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMA
|.... | |||||.||.||.. ...|. |.|. .| . . ..
lervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 3-50 | 7e-10 | 33.5 | In-house | 243-290 (307) | alignment | ||
Range on Protein: 3-50
Range on HMM: 243-290/307.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQ
|.||. || ||.|..|| ||.. ..|||| |. .|| | . ...
lqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 3-50 | 2.3e-09 | 31.8 | In-house | 199-246 (250) | alignment | ||
Range on Protein: 3-50
Range on HMM: 199-246/250.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQ
|..|. | ||||...|.||.| ....||| | .|.|. . . ..
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 3-52 | 4.5e-09 | 30.8 | In-house | 237-286 (318) | alignment | ||
Range on Protein: 3-52
Range on HMM: 237-286/318.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQEN
|.... | |||||.|| ||. |.| . |...| .| .| . .
lerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 3-50 | 4.8e-08 | 27.5 | In-house | 245-292 (325) | alignment | ||
Range on Protein: 3-50
Range on HMM: 245-292/325.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQ
|... | ||.|. || ||.| .|... . | |.| | . ..
lakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 3-42 | 6.4e-08 | 26.8 | In-house | 234-273 (314) | alignment | ||
Range on Protein: 3-42
Range on HMM: 234-273/314.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
|| .| |. ||||..||.|| |.. | ||..| ..
ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
|
|||||||||
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 3-45 | 2.8e-07 | 24.0 | In-house | 233-275 (515) | alignment | ||
Range on Protein: 3-45
Range on HMM: 233-275/515.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHL
. . . ..||||..|. .| . ...| |.| . | ..
vahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
|
|||||||||
subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 3-49 | 5.1e-07 | 24.5 | In-house | 212-260 (284) | alignment | ||
Range on Protein: 3-49
Range on HMM: 212-260/284.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILN--HLMAMS
||... |. |||...|. || . ...|.| .||..| | ||.. |
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
|
|||||||||
subfamily_PTPRG_pd | Subfamily PTPRG | 3-58 | 5.7e-07 | 23.1 | In-house | 244-298 (563) | alignment | ||
Range on Protein: 3-58
Range on HMM: 244-298/563.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAmSQENTLQSTQ
| |.. |.||.||...| .| ..|. |.| . .| ..| |.|. |...|
lkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia.sketellaeq
|
|||||||||
subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 3-49 | 6.1e-07 | 24.0 | In-house | 248-296 (319) | alignment | ||
Range on Protein: 3-49
Range on HMM: 248-296/319.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL-N-HLMAMS
||... |. |||...|. || . ...|.| .||..| | . ||.. |
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
|
|||||||||
subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 3-42 | 2e-06 | 21.9 | In-house | 223-262 (283) | alignment | ||
Range on Protein: 3-42
Range on HMM: 223-262/283.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRIL
.... | ||||..|| .| . ..|.|. ||| . .
vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
|
|||||||||
subfamily_PTPRB_pd | Subfamily PTPRB | 3-51 | 3.5e-06 | 21.3 | In-house | 242-290 (293) | alignment | ||
Range on Protein: 3-51
Range on HMM: 242-290/293.0
LDQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQE
|...| || ||.| || .||.. ....|. ..| .. . .|. ..|
lqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
|
|||||||||
subfamily_PTPN12_pd | Subfamily PTPN12 | 4-50 | 1.6e-06 | 22.2 | In-house | 235-281 (290) | alignment | ||
Range on Protein: 4-50
Range on HMM: 235-281/290.0
DQLEVEDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQ
. ... .|||..| ||.. ..|. | |.| |. . .|. .
kaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkel
|
|||||||||
AAA_PrkA | PrkA AAA domain | 9-68 | 4.8e-06 | 11.7 | Pfam-A | 217-276 (358) | alignment | ||
Range on Protein: 9-68
Range on HMM: 217-276/358.0
EDAVDVFQIVKALRHDNFQMIQSLEDYKLCYRILNHLMAMSQENTLQSTQEFDMEKDDGL
|. |... || . | ... .| .| ..| .|... ||....||... . . ||.
endpdaysysGalnranrGllefvemfkadikvlhplltatqegnyksteklslipfdgi
|