Gene SpurPTP-sf2-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP097_AA protein Get Run
SpurP097_AA_9-244 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 8-240 6.2e-50 164.9 In-house 60-276 (315) alignment 
Range on Protein: 8-240
Range on HMM: 60-276/315.0
KEDRSRPYL-MTPGDRagSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNtrSVTFGPFTVGHKGS
  |.||..| ..  |     .|.||.|. ||.||. .||.| |. ..| ||||||... |..|.||..| .   . .  ||| .   |..|..|| .|  
aydksrvqlpllendp..hsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkse

ENMNRVKVRTLELKYKEEVHEIRQFEVQTWPTwiqsDGVqsqeqCmDAVLQLMDYLRKCEIQRSSEQsrpgdgPPILVHCLSGIEESGVFCTVMNCLEQL
|  ... ||||   ......|. |... .||.     ||     .    . ||.. |.    . ..        .|.||| .|.  .| |.|.   |.|.
evnteytvrtlsvvfgdnirevvqlhytswpd....mgv.....p.kytiplmnlirtvkqhhtnsv......gaivvhcsaGvGrtGtfitldavldqa

NNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
. . ||||.. .. .|  | . | ..  | . |. | 
eaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 9-242 1.3e-50 167.3 In-house 58-282 (305) alignment 
Range on Protein: 9-242
Range on HMM: 58-282/305.0
EDRSRPYlMTPGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQ---LNDKTCSIYWPVNTRS-VTFGPFTVGHKGSE
 | .|   .|. .  . ..|||||.. ||..|...|..| ||..|| |||||. ....|||.|| .    ... |  ||| ...  . ||.|.|  | ..
ldddrii.ltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksek

NMNRVKVRTLELKY---KEEVHEIRQFEVQTWPtwiqSDGVQSQeqcMDAVLQLMDYLRKceiqrsseQSRPGDGPPILVHCLSGIEESGVFCTVMNCLE
...    | |..     ..| . . |... .||     .||  .     ..|.|.. ..|        . . . | |.||||  |.  .|||..|   ||
tasdyieRklkisiededkesrtvlqyqltdWP....dhGvpqf...atsllslikrvqk........dqkkdkgvpllVhCsagvgRtGvfiavdiale

QLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHH
.|.... .|||. |. || .|.. | ||  |  ..  |   
rlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_PTPRK_pd Subfamily PTPRK 9-239 5.6e-47 155.1 In-house 55-273 (314) alignment 
Range on Protein: 9-239
Range on HMM: 55-273/314.0
EDRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKT---CSIYWPVNTRSvtFGPFTVGHKGSEN
 ||||. |.|  .   |..||||... .| . .|||.|| ||..|| ||||||.|.. ..|.||..| ...   |. ||| .|.   .|.. |    .| 
ydrsrvflitidg.dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetel

MNRVKVRTLELKY----KEEVHEIRQFEVQTWPTWiqsdGVQSQEQcmdAVLQLmdyLRKCEIQRSSeqsrpGDGpPILVHCLSGIEESGVFCTVMNCLE
 . . ||.. ..     .||..|.|||.  .||..    .|  ...   ..|.|   .|. . ..       ..| .|.|||..|   .|.|...   |.
laelvvrifrveklargqeeirevrqfqflgWpdh....dvPvsat...gllkl...vrrvkksqee.....eaG.rivvhCsaGaGrtGtfiaidivld

QLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLL
 ....| .|||.  . || ...|.| |   | ..|  .
mieregvvdvfnavktlrsrkvnmveteeqykfiydvi
0046845 (Phosphotyrosine protein) phosphatases II 10-243 1.3e-57 190.7 In-house 41-274 (284) alignment 
Range on Protein: 10-243
Range on HMM: 41-274/284.0
DRSRPYLMTPGDRAGSNNYINASFMSGY-----SKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHK
|.|| .| ..... ....|||||...||      .|..|||||.||..|| ||||.|.......|.||..| ..    |. ||| .  ..|.|.|||  .
dhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtll

GSENMNRVKVRTLELKY---KEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLRKceiqrsseqsrPGDGPPILVHCLSGIEESGVFCTVM
  |... ..||||||..   ..|......| . .||     .||  | |. .. . .. ..|..            ..|.||.|||  |.  .|.|....
seevkddytvrtleltnlgytgesrtvthfhytswp....dhgvppspedlleflrlvrellen...........lpgggpivVHCsaGvgRtGtfiald

NCLEQLNNDG---AIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
 .||||...|    .||.. .. ||  ||..| ||  |...|..| .. 
llleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 10-241 2.4e-57 190.0 In-house 62-284 (288) alignment 
Range on Protein: 10-241
Range on HMM: 62-284/288.0
DRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVnTRSVTFGPFTVGHKGSENM
|.|| .| ....  ....|||||...|| .|..||||| ||..|| ||||.|.......|.||..| ..   .|  |||    |.|.|..||  .  | .
dhsRVkLsvldg.vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevl

NRVKVRTLELK------YKEEVHEIRQFEVQTWPtwiqSDGVQS-QEQCMDAVLQLMDYLRkceiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNC
. ..|||||..      ...|......| . .||     .|| .  |...| . .....|.              .|.|..|||  |.  .|.|...  .
ddytvrtlevtnldlldgdgesrtvthfhytnwp....dhgvpdspellldflrlvrkala.............sgggpvvVHCsaGvgRtgtfialdll

LEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
||||.. | .||.. .. ||  ||. |.|.  |...|..| .
leqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0050432 (Phosphotyrosine protein) phosphatases II 10-243 2.6e-57 189.9 In-house 81-299 (308) alignment 
Range on Protein: 10-243
Range on HMM: 81-299/308.0
DRSRPYLmtpgdrAGSNNYINASFMSGY--SKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN--TRSVTFGPFTVGHKG
|.|| .|       ....|||||...||   ....||||| ||..|| ||||.|.......|.||..| .   ..|  ||| .    |...|.||| .. 
dhsRVkl......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtlls

SENMNRVKVRTLELKY--KEEVHEIRQFEVQTWPtwiqSDGVQSQeqcMDAVLQLMDYLRKCEiqrsseqsrpgDGPPILVHCLSGIEESGVFCTVMNCL
 |... ..||||||..  ..|......|   .||     .|| ..   ....|......||.            .|.||.|||  |.  .|.|...  .|
eevlddytvrtleltnlgdgesrtvthfhytnWp....dhgvPps...peilldflelvrksl...........pggpivVHCsaGvGRtGtfialdlll

EQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
|||. .| .|||. .. ||  ||. |.|.  ||..|..| .. 
eqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
subfamily_PTPRD_pd Subfamily PTPRD 10-243 2.8e-55 183.0 In-house 61-281 (564) alignment 
Range on Protein: 10-243
Range on HMM: 61-281/564.0
DRSRPYLMTPGDRaGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTrSVTFGPFTVGHKGSENM
|.||  | .      . .||||||. || |..|.|||| || .|. ||||.| ....|||.||..|..|    |. ||| .. . |.| .||  . .|..
dhsRVvLskvegd.egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeel

NRVKVRTLELK--YKEEVHEIRQFEVQTWPtwiqSDGVQSQEqcmDAVLQLMDYLRKCEiQrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLN
. . .||..||   ..|..|.|||    ||    . ||  .     ..|.|..  |... .         |  ||.||| .|.. .|.|...  .||...
adyeirtfklkkkkssesreVrqFhFtsWP....dhgvpesa...tslLdlirkvraln.e........pdagPivVhCSaGVGRTGtfividamlerik

NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
... .|..| ...||  |.  | | . |  ... . .  
eektvDiyqyvkalrkqRnamVqteeQYiFiheaileal
0036941 (Phosphotyrosine protein) phosphatases II 10-243 4.5e-55 182.4 In-house 52-277 (297) alignment 
Range on Protein: 10-243
Range on HMM: 52-277/297.0
DRSRPYLmtpgdRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN-TRSVTFGPFTVGHKGSEN
|..| .|       ....|||||...||. |..||||| ||..|| ||||.|.......|.||..| .   ..|  ||| .   |.|.|.|||  .. | 
dhtRVkl.....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvev

--MNRVKVRTLELKY--KEEVHEIRQFEVQTWPtwiqSDGVQS-QEQCMDAVLQLMDYLRKCeiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCL
   . ...||||...  ..|......| . .||     .|| .  ....| . .. ..|..             .|.|.||||  |.  ||.|...  .|
vllddytlrtlevtdtgngesrtvthfhytgwp....dhgvpespaslldfielvrkvlkll...........psggpvlVHCsaGvgRsgtfiaadlml

EQLN---NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
.||.     | .|... .. ||  ||. |.||  |. .| .| .. 
qqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0040438 (Phosphotyrosine protein) phosphatases II 10-243 1.8e-54 180.5 In-house 56-276 (317) alignment 
Range on Protein: 10-243
Range on HMM: 56-276/317.0
DRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVnTRSVTFGPFTVGHKGSENM
|.|| .|  .|    ...|||||...|...|..||||| ||..|| ||||.|.......|.||..| ..   .|  |||    ..|.|.||| ... | .
dhsRVkLsplgg.dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeel

NRVKVRTLELK--YKEEVHEIRQFEVQTWPtwiqSDGVQSqeqCMDAVLQLMDYLRKCEiqrsseqSrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLN
. ...||||..  ...|......|   .||     .|| .    .| .|......|..        .  ..| |.||||  |.  .|.|...  .||||.
agitlrtlevedlgdsesrtvthfhytgWp....dhgvpp...spdllldfleavreal.......e..dpggpvlVHCsaGvgRtGtfiaaylmleqle

NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
  | .||.. .. ||  ||. |.|.  |  .|..| ...
keggvdveeavkelreqRpgavqtpeqyrflydalleyl
0039614 (Phosphotyrosine protein) phosphatases II 10-242 5.5e-54 179.0 In-house 69-288 (297) alignment 
Range on Protein: 10-242
Range on HMM: 69-288/297.0
DRSRPYLMTPGDRAGSNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKT--CSIYWPVNTRsvTFGPFTVGHKGSENM
|.|| .| .....  ...|||||...||.. ...||||| ||..|| ||||.|.......|.||..|...   |  ||| ..   |.|.|||  .. |  
dhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehl

NRVKVRTLELKYKEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLRKCeiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNN
. ..|||||.....|......| .  ||     .||  | |...... .....|...           ..| |.||||  |.  .|.|..   .||||. 
dgytvrtlevtnngesrtvthfqytgwp....dhgvppslellleflelvrealael...........pkggpvlVHCsaGvgRtGtfiaaylmleqlek

DGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHH
 | .||.. .. ||  ||. |.|.  |  .|..| ..
eggvdvleavkelreqRpgavqtpsqyrflydallel
0047943 (Phosphotyrosine protein) phosphatases II 10-241 6.1e-54 178.7 In-house 51-270 (273) alignment 
Range on Protein: 10-241
Range on HMM: 51-270/273.0
DRSRPYLmtpgdRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTR--SVTFGPFTVGHKGSE
|.|| .|       |...|||||...|| .|..|||||.||..|| ||||.|.......|.||..| ..   .|  ||| .    |.|.|.||| ... |
dhsrvkl.....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllsee

NMNRVKVRTLELKY--KEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLRKCEIQrsseqsrpgdgPPILVHCLSGIEESGVFCTVMNCLE
. . ..||||||..   .|......| . .||     .||  | |.... . .....|...  .           .|..|||  |.  .|.|...  .|.
tkddytvrtleltnlgtgesrtvthfhytgwp....dhgvppslesllefielvrkalealpsn...........gpvvVHCsaGvgRtgtfialdllld

QLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
||.  | .||.. ..|||  ||. |.|.  |...|..| .
qlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 10-241 2.9e-53 177.0 In-house 68-302 (307) alignment 
Range on Protein: 10-241
Range on HMM: 68-302/307.0
DRSRPYLMTPGDRAGSNNYINASFM--------SGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVNTRSVTFGPFTV
|..| .|...... ....|||||..        .|| .|..||||| ||..|| ||||.........|.||..|    .. |  ||| .  ..|.|.|||
dhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftv

GHKGSENMNRVKVRTLELK---YKEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLRKceiqrsseqsrPGDGPPILVHCLSGIEESGVFC
  .. | .. ..|||||..   ...|......|   .||     .||  | |.. | . .....|..            ..| |.||||  |.  .|.|.
tllseehldgytvrtlevtdldgtgesrtvthfhytgwp....dhgvppsfeelldfieevrkalee...........lpkggpvlVHCsaGvgRtGtfi

TVMNCLEQLNNDGA---IDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
.   .|.||...|    .|... ..|||  ||. |...  |  .|..| .
aaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 10-240 3.4e-53 175.8 Pfam-A 14-234 (235) alignment 
Range on Protein: 10-240
Range on HMM: 14-234/235.0
DRSRPYLmtpGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWP-VNTRSVTFGPFTVGHK-GSE
|..|  |    .. |...||||....||..|..|||||.||.||. ||||.| ......|.||..|..|   .|. |||  . .|.|.| ..|  |  ..
dktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekek

-NMNRVKVRTLELKYKEEV---HEIRQFEVQTWPTWIqsdgvqsQEQCMDAVLQLMDYLRKCEiqrsseqsrPGDGPPILVHCLSGIEESGVFCTVMNCL
 ..... .|.|||| |.|    .|..|. ...|| .          .. ...|.|.. ..| .           .  |..|||  |.. .|.|.... .|
edekeytlrklelkkkkeesekrevkqlhytnWpdhg.......vpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgtfvaldill

EQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
|||.... .||.| .. || .||. | .|. |  .||...
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 10-240 3.4e-53 175.8 In-house 14-234 (235) alignment 
Range on Protein: 10-240
Range on HMM: 14-234/235.0
DRSRPYLmtpGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWP-VNTRSVTFGPFTVGHK-GSE
|..|  |    .. |...||||....||..|..|||||.||.||. ||||.| ......|.||..|..|   .|. |||  . .|.|.| ..|  |  ..
dktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekek

-NMNRVKVRTLELKYKEEV---HEIRQFEVQTWPTWIqsdgvqsQEQCMDAVLQLMDYLRKCEiqrsseqsrPGDGPPILVHCLSGIEESGVFCTVMNCL
 ..... .|.|||| |.|    .|..|. ...|| .          .. ...|.|.. ..| .           .  |..|||  |.. .|.|.... .|
edekeytlrklelkkkkeesekrevkqlhytnWpdhg.......vpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgtfvaldill

EQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
|||.... .||.| .. || .||. | .|. |  .||...
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 10-241 1.3e-51 170.7 In-house 61-286 (325) alignment 
Range on Protein: 10-241
Range on HMM: 61-286/325.0
DRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN--DKTCSIYWPVN-TRSVTFGPFTVGHKGSENM
|.||. | | .| ..| .|||||..  . ||. |.|.|.|| .|. |.|||| |.| | ...||.|.  .. |..||| .   |.|||.. |  .  |..
dksrvvletkkd.dpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei

NRVKVRTLELKYKE--EVHEIRQFEVQTWPTWiqsdGVQSQEQCMDAVLQLMDYLRKCeIQRSSEQSRpgdgpPILVHCLSGIEESGVFCTVMNCLEQLN
     | |..|  .  |   ..||..|.|.      ||| .  .. ..|||.. . .. ..  .. |      |||||| .|.  .||| ..   |... 
sdyvhrvldvkqvkkGetrsvkqfqlqswddm....Gvqkrpatlisilqlvkavser.vtantkast.....pilvhcsaGvGrtGvfislysalakvi

NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
..  .|.|. .. ||  ||. | |   | |.|. |. 
eesrvdifgfvkklrkdrpsmvetvdqyiliyealve
0043336 (Phosphotyrosine protein) phosphatases II 10-241 3.2e-51 169.8 In-house 58-275 (278) alignment 
Range on Protein: 10-241
Range on HMM: 58-275/278.0
DRSRPYLMTPgDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPvnTRSVTFGPFTVGHKGSENM
|.|| .|    .   ...|||||...||.....||||| ||..|| ||||.|......||.||..| ..   .|  |||    |.|.|.|||  .. | .
dhsrvklsll.ggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehl

NRVKVRTLELK--YKEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLrkceiqrsseqsRpGDGPPILVHCLSGIEESGVFCTVMNCLEQL
. ..|||||..  .. |.......    ||     .||  | .. .| . .....|            .  .. |.||||  |.  .|.|...  .||||
ddytvrtlevtnlgdgesrtvthyhylgwp....dhgvpeslsllldflkavreal............e.dsngpvlVHCsaGvgRTGtfialyllleql

NNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
.. | .|... .. ||  ||. |.|.  |  .|..| .
ekeggvdleeavkelreqRpgavqtpsqyrflyealle
DSPc_SM00195 10-240 3.3e-51 169.5 In-house 39-259 (263) alignment 
Range on Protein: 10-240
Range on HMM: 39-259/263.0
DRSRPYLMTPGDRaGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN-TRSVTFGPFTVGHKGSEN
|..|  | .. ..  ...||||....|..||...||||.||.||| ||||.| . ....|.||.. ..   ..|. ||| .  .. ||| ..|  .  |.
dhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevek

MN-RVKVRTLELKYKE--EVHEIRQFEVQTWPTWiqsdGVQSQEQcmdAVLQLMDYLRKCEIQRsseqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQ
..  ...|||||....  | ....|.....||      ||.....    ||.|. ...|.. .           .||.|||  |.. .|.|.|.  .|..
kkdeiilrtleltkegkeetrkvtqyqyknWpdh....gvpdstk...svlellravkksksts.........sgpivVhCsaGvgRtgtfvtidiilsk

LNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
|...  .|.|. .. || .||. | ||. || .|. . 
leeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
PTPc_SM00194 10-240 3.3e-51 169.5 In-house 39-259 (263) alignment 
Range on Protein: 10-240
Range on HMM: 39-259/263.0
DRSRPYLMTPGDRaGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN-TRSVTFGPFTVGHKGSEN
|..|  | .. ..  ...||||....|..||...||||.||.||| ||||.| . ....|.||.. ..   ..|. ||| .  .. ||| ..|  .  |.
dhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevek

MN-RVKVRTLELKYKE--EVHEIRQFEVQTWPTWiqsdGVQSQEQcmdAVLQLMDYLRKCEIQRsseqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQ
..  ...|||||....  | ....|.....||      ||.....    ||.|. ...|.. .           .||.|||  |.. .|.|.|.  .|..
kkdeiilrtleltkegkeetrkvtqyqyknWpdh....gvpdstk...svlellravkksksts.........sgpivVhCsaGvgRtgtfvtidiilsk

LNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
|...  .|.|. .. || .||. | ||. || .|. . 
leeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
0040439 (Phosphotyrosine protein) phosphatases II 10-241 3.8e-50 166.2 In-house 24-244 (249) alignment 
Range on Protein: 10-241
Range on HMM: 24-244/249.0
DRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVnTRSVTFGPFTVGHKGSENM
|.||..|   ..    ..|||||...||  |..||||| ||..|| ||||......|..|.||..|     ..|  |||    |...| |||  .  | .
dhsrvklsilpg.lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevk

NRVKVRTLELK--YKEEVHEIRQFEVQTWPtwiqSDGVQ-SQEQCMDAVLQLMDYLRKCeiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQL
. ..||||||.  |. |....... .  ||     .||  | |...| . .....|...           ..| |.||||  |.  .|.|..   .||||
ddytvrtleltnlydgesrtvlhiqytdwp....dhgvppsfedlldfieavrkaleel...........pkggpvlVHCsaGvgRtGtfiaaylmleql

NNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
.  . .|... ..|||  ||. |...  |  .|..| .
ekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 10-242 4.6e-47 156.1 In-house 37-271 (278) alignment 
Range on Protein: 10-242
Range on HMM: 37-271/278.0
DR---------SRPYlmtpgdragsnNYINASFMSGYskKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPvNTRSVTFGPFT
.|         || .           .|||||...||  ...||||| ||.||| ||||......|..|.||..| ..    |  ||| .  |.|.|.||
nRykdilpydhsrVk...........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.eggsltygdft

VGHKGSENMNRVKVRTLELK------YKEEVHEIRQFEVQTWPtwiqSDGVQSQE--QCM-DAVLQLMDYLRKCEIQRSSEQSRPGDGPPILVHCLSGIE
|  .  |... . .|||..       .  | ......   .||      || |..  . . ... .. ..|..   . .|. .  ..| |.||||  |. 
vtllseevlddytlrtllvtnltveredlesrgvthlhylpwp....dhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

ESGVFCTVMNCLEQLnnDGAIDVFQNLRLLRLSRPN-FVPTLTDYLLCYKLLTHH
 .|... .. .||.|  .| .|... .. ||  ||.  |..|  |  .|..| ..
RtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
0042113 (Phosphotyrosine protein) phosphatases II 10-239 1.4e-46 154.2 In-house 22-239 (245) alignment 
Range on Protein: 10-239
Range on HMM: 22-239/245.0
DRSRPYLMTPGDRAGsNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVnTRSVTFGPFTVGHKGSENM
|..| .|. .| . . ..|||||...||  .. ||||| ||..|| ||||......|.||.||... .   ..|  |||    |.|.| |||  .. |..
dhtrvklspdggdld.sdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehl

NRVKVRTLELK--YKEEVHEIRQFEVQTWPtwiqSDGVQSQEQCMDAVLQLMDYLRKCeiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLN
. ..|||||..  .. |..|....    ||     .|| .  . .. .|....  ..            ... |.||||  |.  .|.|...  .||||.
ddytvrtlevtnlgddesrevihyhylpwp....dhgvpdllellldflefvrkalae...........dsngpvlVHCsaGvgRtGtfiaaylmleqle

NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLL
  . ..... .. ||  ||. |.|.  |  .|..|
kelgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 10-251 2e-46 153.5 In-house 61-291 (319) alignment 
Range on Protein: 10-251
Range on HMM: 61-291/319.0
DRSRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNtRSVTFGPFTVGHKGSENM
||.|  |..  .   . .||||||. || ....||||| ||. |. ||||.| ....|...||..|..|    .. ||| .   ...| ..|  .  |..
drtrvvlseldg.vegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeel

NRVKVRTLELKYKEE-V--HEIRQFEVQTWPtwiqSDGVQSQeqcmdaVLQLMDYLRKceIQRSSEQsrPGDGpPILVHCLSGIEESGVFCTVMNCLEQL
. . .| |.|. | . |   |. .|  . ||     ..|  .       ..|.| |..  |..| |.  . .| || |||  |.   | |...   ||..
edyiirklklnkkssevetRevkhfqyteWp....dhdvPek......atslldllkr..irksrek..tqsg.PivvhCsaGvGRtGtfivldamlerv

NNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHHTLCRSEEE
...|..|||.  . ||. |.  | .   | ..|. | .  .   .| |
keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteie
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 10-242 1.9e-44 147.0 In-house 59-279 (318) alignment 
Range on Protein: 10-242
Range on HMM: 59-279/318.0
DRSRPYLMTPGDRAGSnNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPvNTRSVTFGPFTVGHKGSENM
|..|  | .  .  || .||||... || .|.|.||.| ||  |. ||||.| .   ..|.|| |....    .  ||| .  | ..|  .|  | . ..
dhtrvkLqmlegeegs.DyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsygklvvelkeevel

NRVKVRTLELKYKE--EVHEIRQFEVQTWPtwiqSDGVQSQEqcmdavLQLMDYLRKCEiqrsSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLN
.   .|..... .|  |. ..||... .||      || ..        .|.| .|. .    . | ..| | ||.||| .|.   |||..|   ||...
sdyvlrefkvtrteeeesrqvrqyhytsWp....degvpesg......aslldlvrqvs....kaqqksgag.pivvhCsaGvGrtGvfiavdillerik

NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHH
... .||||  . ||  |.  | |   | ..|. |.  
aealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 10-240 2.8e-44 146.4 In-house 64-281 (297) alignment 
Range on Protein: 10-240
Range on HMM: 64-281/297.0
DRSRPYLMTPGDRAGSnNYINASFMSGYSKknAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN--DKTCSIYWPVNTrSVTFGPFTVGHKGSENMN
|.||  |   .|   | .|.||||. |. .   .|.|||| ..|| |||..| |...|||.|||..|  || |  ||. .. ..|||  .|  .  .. .
dssRvkLaivnddpds.Dyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkg.vttfGdvsvvllsvsere

RVKVRTLELKYKE--EVHEIRQFEVQTWPTwiqsdGVQSQEQCMDAVLQLMDylrkcEIQRSSEQSRPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNN
    |.||..  .    . ..|..   ||.      .  ... . ..|.|..     |.. . .|   |   |.|||||.|.   ||..|. ... . ..
GfikrelevtkgkakarrvvkqyqfveWPd.....kaverkdsassllklis.....evrkdfsqnaeg...PllvhclaGvGrtgvlltidsvvaeakr

DGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
. ..|.|. .. || .||..| |  .| . |... 
ekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_PTPRG_pd Subfamily PTPRG 10-241 4.7e-44 145.5 In-house 60-285 (563) alignment 
Range on Protein: 10-241
Range on HMM: 60-285/563.0
DRSRPYLMTPGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVnTRSVTFGPFTVGHKGSENM
||||  |    .  .. .||||... || |..|||||| || .|. ||||.. . . ..|.|. .|..   . | .|||    |.|.| ..|  . .| .
drsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevl

NRVKVRTLELKY-----K---EEVHEIRQFEVQTWPTWIQSDgvqSQeqcmdaVLQLmDYLRKCeiqrssEQSRPGDGPPILVHCLSGIEESGVFCTVMN
    |||| .|      |   ......||..  .||     .   ..      . .|  . .|       ..... .  ||.||| .|. ..|... .  
alytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe...hs......lpvL.ifvkks......saankaeaGPivvHcsaGvgrtGtyivldt

CLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
 |.|.... |..||. |. .|. |.. | |  .|.  .. |  
llkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_CG7180_pd Subfamily CG7180 10-246 2.1e-43 143.0 In-house 55-292 (296) alignment 
Range on Protein: 10-246
Range on HMM: 55-292/296.0
DRSRPYLMTPGDRAGSNnYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK--TCSIYWPVNTrSVTFGPFTVGHKGSENMN
|  |..| . .  . |. ||||... .. ||...| |..| ..|| .|||||.|  ||....| .  |    .  ||| ..    .|.. |    .... 
DynRvvLekldGeeksd.YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks.keqygeifveiveekqya

RVKVRTLELKYK----EEVHEIRQFEVQTWpTWIQSDGVQSQEQCMDAVLQLMDYLRKCEIQRSSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQL
 .| ||. |. |     | ..  . |. .  . .|    ......      |.. .|. .. |   . .|  | |..|..  |   |||....  .||..
nlkirtfkltkkivalteqekqvkaetRiv.klfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg.PvvvvssdGasRsGvylaidanlelv

NNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHhTLC
.... .|||. .. || |||. | . ..|  .| .| ..  ||
ekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea.vlc
subfamily_PTPRB_pd Subfamily PTPRB 10-240 5.7e-43 142.0 In-house 64-282 (293) alignment 
Range on Protein: 10-240
Range on HMM: 64-282/293.0
DRSRPYLMTPGDRAGsNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKGSENM
| ||  |..  |..| ..||||....||. .. ||||| || .|| ||||.|.. . |.|.|| || .|    |  ||| ....|..|  .|  . .|..
dhsrvkLaalkdesg.sDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeel

NRVKVRTLELKYKEEVHEIRQFEVQTWPTWiqsdGVQSQEQCMdavLQLMDYLRKCeIQRSSEQSrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNND
.   .|.|... ..| ...||.. ..|| .    || .. . .   |...  .|.  |.......      ||.||| .|.  .|.| .. . |......
edwvirelkiekekeerkvrqyhftsWpdh....gvPektktl...ldfvrtvrea.iektaskr......PivvhCsaGvGRtGtfialdrllqaieee

GAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
  .|.|  .  || .| ..| | ..|.  .. . 
dyvdifgivaelReeRnllvqtekqYifihqcvl
0037934 (Phosphotyrosine protein) phosphatases II 10-241 1.5e-42 141.2 In-house 23-240 (243) alignment 
Range on Protein: 10-241
Range on HMM: 23-240/243.0
DRSRPYLmtpgdrAGsNNYINASFMSGYSKknaFIATQMPLDSTVLD----FWRLVHDYRISTIIMLNQLN---DKTCSIYWPvntRSVTFGPFTVGHKG
|.|| .|       | ..||||... .. .   .||||.||..|| |    |||......|..|.||..|     . |  |||    .||.|.|||  ..
dhsrvkl......eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gevtygdftvtlls

SENMNRVKVRTLELKY---KEEVHEIRQFEVQTWPtwiQSDGVQSQEQCMDAVLQLMDYLRKCEiqrssEQSRPGDGPPILVHCLSGIEESGVFCTVMNC
.|... ..||||.|..   ..........    ||     .  .| |...| . .. ......            .| |.||||  |.  .|....   .
eehlddytvrtlllenldlddltrlvihyhylpwp...dhgvPdspedlldfldevrefieell.....sllaldsggpvlVHCsaGvgRtGtliaaylm

LEQLnndGaIDVFQNLRLLRLSRPN-FVPTLTDYLLCYKLLTH
|..|   | .|... ..|||  ||.  |.|.  |  .|..| .
llll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 10-243 8.6e-39 128.3 In-house 41-268 (274) alignment 
Range on Protein: 10-243
Range on HMM: 41-268/274.0
DRSRPYLMTPGDRAGSNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTRS---VTFGPFTVGHKG
..||  | .   ..   .|||| .. ||.. ..|..||| || .|| ||||...  ... |.|| .|..   . |. |.| ..      ..| . .  ..
ensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvek

SENMNRVKVRTLELKYKEEVHEIRQFEVQTWPTWIQSDGVQSQEQCMDAVlqlmdylrkceiqRSSEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQ
  . |  .||.| ||| |. ...  .    ||   . | ...  . .. |             ..|....     |..||| .||   |.| .. ... |
iverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvlev.............eesreeenaklapvvvhCsaGiGrtGcfiaisiavrq

LNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHH
|.... .||..    ||| |   | |   | | .. |....
lreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 10-237 3.6e-29 96.7 In-house 16-233 (237) alignment 
Range on Protein: 10-237
Range on HMM: 16-233/237.0
DRSRPYLMTPGDRagsNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL---NDKTCSIYWPVNTRSVTFGPFTVGHKGSEN
| ||  |  .|      .||||... |.    . .||.| ||.|.  |||..| . . | |.||  |   |.. |  |||   .  ..| .||  |  |.
dhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkee

MNRVKVRTLELKYKEEVHEIRQFEVQTWPTWIqSDGVQSQeqcMDAVLQlmdyLRKCEIQRSSEQSRPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNN
.    ||.| | .. ...|.|      . .|    ||  |     |.|.    .||  |.||   |. |   | ..|| .|.  .|.|  .   | | ..
fsdytvrslllskrltlkevrlihqyqftswp.drgvpqq...taallr....frkniinrsphvsesg...pwiihcsagvgrtgiflvidamlrqake

DGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYK
   .|... .  .   ||  . |  .|.. ..
kkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 11-241 1.9e-52 173.4 In-house 70-288 (298) alignment 
Range on Protein: 11-241
Range on HMM: 70-288/298.0
RSRPYLMTPGdRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNtRSVTFGPFTVGHKGSENMN
 ||  | .        .||||||...|...||||||| || .|| ||||.| .. |.||.||..|...   ... ||| . .. |.| .||  . .|.. 
ssRvvLeked.adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefa

RVKVRTLELKYKE--EVHEIRQFEVQTWPtwiqSdgvQSQEQCMDAVLQLMDylrkcEIQRssEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNN
 . ||.|... |.  . .|.||... .||    .   ..  . . .||.|..     ....   |.. |.  |..|.| .|.. || |. .   ||....
dlivrklkvskkkeekerevrqlhftsWp....d...kgvpenatsvldllr.....kvra..sqqqagnk.pvivqCsaGvgRsGtfiaidsvlervkk

DGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
.  .|||| .. || .||. | | ..|  .|..  .
eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle
subfamily_PTPN9_pd Subfamily PTPN9 12-240 1.3e-43 144.2 In-house 57-287 (297) alignment 
Range on Protein: 12-240
Range on HMM: 57-287/297.0
SRPYLMTPGDrAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPV-NTRSVTFGPFTVGHKGSENMN
.|  | .  .     .||||.|. || .|.|||||| ||. || ||||.| . .. .|.|  .. ..    |. |||  .  |  || ..| .   |...
trvvlakvde.deasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeee

RVKVRTLELK--YKEEVHEIRQFEVQTWPTWiqsdGVQSQEQCMDAVLQLMDYLRKCEIQRSSEQ-SRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLN
  |||.||.|   .||  ..  | . .|| .    || |. . .  ||. .   . . ..  ...   . .||||.||| .||  .| |.|.  ||..|.
dykvrvleiknvkteesrkvthfqflsWPdy....GvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrle

NDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
. | .||.. ..|||  |   . |   | .||. . 
evgtvdvvetvkllrtqrafsiqtpeqyefcylavl
0049772 (Phosphotyrosine protein) phosphatases II 12-244 9.7e-28 93.2 In-house 60-281 (314) alignment 
Range on Protein: 12-244
Range on HMM: 60-281/314.0
SRPYLmtPGDRAGSNNYINASFMSGYskkNAFIATQMPLDSTVLDF----------WRLV--HDYRISTIIM---------------------LNQLNDK
.|  |  ||    . .|||||...|.   ..||||| ||. || ||          ||.|   |... .| |                     |..|  .
nrvil..pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgn

TcsiywpvntrsvtfgpftvGHKGSENMNRVKvrtlelkykeevheirqfEVQTWPTWIQSDGVQS--------QEQCMDAVLQLMDYLRKCeiQrsseq
.                   ..   ...   |                  |....| . .  |..         ..   . ...........  .     
g...................neptaadlellk..................eelydpelferlgikylripvpDgsaplledfdeflefieea..d.....

srpgDGPPILVHCLSGIEESGVFCTVMNCLEQLNndgaIDVFQNLRLLRLSRP-----NFVPTLTDYLLCYKLLTHHHT
    .| |.|||| .|.  .|.|.... .. .|.    ... . |. .|| ||     .|...| .|. ... | ..  
....kggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk
0041856 (Phosphotyrosine protein) phosphatases II 13-241 1.2e-30 101.8 In-house 8-169 (182) alignment 
Range on Protein: 13-241
Range on HMM: 8-169/182.0
RPYLMTPGDRagSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNqlndktCSIYWPvntrsvtfgpftvghkgsenmnrvkvr
. .|. . .|   ..||||... |. . . ||||| ||.||| ||.|......|.||..|.      .  |||                           
sdilpydhsr..dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp...........................

tlelkyKEEVHEIRQFEVQTWPTWIQSDgvqsqeqcMDAVLQLMDYLRKceiqrsseqsrpgDGPPILVHCLSGIEESGVFCTVMNCLEQlnndGaIDVF
      ... ... |.    || .   |        .| .|....  ..             .| |.||||  |.  .|...    ....    | ....
......ellerlgiqylylpwpDhgvpd........ldelldfieevle.............eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsle

QNLRLLRLSRPNFVPTLTDYLLCYKLLTH
. ..|.|  ||. | |.  | ... .| .
eavklvrsrRpgmvitpnqyfflqlalle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 16-240 2.1e-48 159.9 In-house 65-276 (288) alignment 
Range on Protein: 16-240
Range on HMM: 65-276/288.0
LMTPGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL---NDKTCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVR
 .. ..   ...|||||.. |. ||...|||| || .|| |||.||.....|||.||..|   ....|  ||| . . . .| .||  ..|.... . .|
klkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlr

TLELKYKEEVHEIRQFEVQTWPtwiqSDGVQSQEQcmdavlQLMDYLRKCEIQRSSEqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVF
.|.|. |..  || |.. ..||     .||  ...      .|...||. ... ...        ||.|||  |.  .|.| .. . .......  |||.
klllekkkteleitqyqylaWp....dhgvPeska......pllellrqvkvanqad......tgpiivhCsaGvGrtgtFialdalidaveeedyiDva

QNLRLLRLSRPNFVPTLTDYLLCYKLLT
  .  || .|...| ||. |  .|. | 
gtvaklRkqRallvqtlkqYefiyevll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 16-240 2.4e-33 110.5 In-house 59-273 (281) alignment 
Range on Protein: 16-240
Range on HMM: 59-273/281.0
LMTPGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVR
 .|| ... ...||||.|..||......|||| |. ... .||..| ....|.|.|. .        |  ||| .. ....| .|| .. .|. ..   |
kvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyier

TLEL-KYKEEVHEIRQFEVQTWPtwiqSDGVQSQEQcmdavlQLMDYLRkcEIQRSSEQSRPgdgPPILVHCLSGIEESGVFCTVMNCLEQLNND-GAID
...| . . |  |..|.. ..||      || .. .      .|... .  |... .|...     |...|| .|.  .|.. ..   .......   .|
kfkleresgetreveqlaytaWP....dhGvPattk......ellefrk..evlkltekktk...aplvihCsaGvGrtGtyialDrlvkaveaeleeld

VFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
| . .. || .|  .| |.. |   || . 
vkavvaelrkernlmvqtvvqyefvykavl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 18-240 6.6e-44 144.9 In-house 68-280 (290) alignment 
Range on Protein: 18-240
Range on HMM: 68-280/290.0
TPGDRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVNTRSVtFGPFTVGHKGSENMNRVKVRTL
 .|..  .|.||||... ||..|...|||| |. .|. |||.|. . ... |.|| . .    ..|  ||| .  .  .|.|..     |..|.   |.|
isghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierkl

ELKYKEE---VHEIRQFEVQTWPtwiqSDGVQSQEQCMDAVLQlmdylRKCEIQRsseqsRPGdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDV
|.| |..    ... |.....|.    |.|   ..| .  |..     .  ..||     ..|   .|.|||  ..  |.|||.... ... . .| |||
evknknsagakqsvtqyqitnwd....stgkvtnpqtillvie.....emyktqr.....krg.ntsivvHCSdtvgrsavfcaaattinkcktegvidv

FQNLRLLRLSRPNFVPTLTDYLLCYKLLT
|| |. .|  .|. | |   | . .... 
fqvlksqRiqkpgsvqtvqqyqgifqivl
subfamily_ptpA1_pd Subfamily ptpA1 20-204 3.1e-19 64.0 In-house 70-257 (418) alignment 
Range on Protein: 20-204
Range on HMM: 70-257/418.0
GDRAGSnNYINASFMSGYSKKnAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHK--GSENM--------
 |. || .|||| .. |   |  ||.|| ||  |. ||||.| . |   |.||.. ...    |  ||| .     |  .  | .  |. ..        
qdkegs.dyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqd

--NRVKVRTLELKYKEEVHEIRQFEVQTWPTWIQSDGVQSQEQCMDAVLQlmdylRKCEIQRSSEQSRpgdgpPILVHCLSGIEESGVFCTVMNCLEQLN
    .  | . | .. | ..| |.. . ||     |  |   | . .. .     |. .|  ||..       ||.||| .|.  .| ||| .  ...|.
pereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitn.....rqnqiipssdrnv.....piivhcsagvgrtgtfctavimmkkld
subfamily_PTPRA_pd Subfamily PTPRA 21-250 4.4e-44 145.7 In-house 81-302 (330) alignment 
Range on Protein: 21-250
Range on HMM: 81-302/330.0
DRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELK
.   . .||||||. || .|. |||.| |.. || ||||.. ... .||.|| .|..   . |  ||| .  .||.|  .|  . .. .. . || . ..
eGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvq

------YKEEVHEIRQFEVQTWPTWiqsdGVQSQEQCMdavLQLMDYLRKCEIQRsseqsrpGDgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDV
       ....  .|||  ..||      || .. . |   |.|.  ..|.. |        ..  || ||| .|.  .| |... . ||... .. .||
qlpdatrekksrlvrqfhftswPdv....GvPfepiGm...lkllkkvkklnqqs.......ag..pivvhcsaGvGrtGtfivldavlervkaerkvdv

FQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHHTLCRSEE
|. .. ||| ||. | |.  | ..|| | ...    .| 
fefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel
subfamily_PTPN12_pd Subfamily PTPN12 21-240 1.9e-38 127.0 In-house 63-274 (290) alignment 
Range on Protein: 21-240
Range on HMM: 63-274/290.0
DRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQ---LNDKTCSIYWPVN-TRSVTFGPFTVGHKGSENMN-RVKVRTLE
.    ..||||.|. | ..| ..||.| ||  |. ||||.. ..... ..|. .   |. | |  ||| .  ....||.|.|  .  ....    .|||.
eeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLk

LKYKEEVHEIRQFEVQTWPTwiqsDGVQSQeqcMDAVLQLMDYLRKCEIqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNND---GAIDVF
.. ..| ....||. . ||      || |.   .. .|.|.. .|. .           .  |..||| .|.   |. ...    |.|...     .|||
veaqkesrkvyqfhYtaWPD....hgvPss...aksllelielvrelqe.........sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvf

QNLRLLRLSRPNFVPTLTDYLLCYKLLT
. .. ||  |.  | |   | | || ..
dlvlelrkqraalvqtkeqyelvykava
0044763 (Phosphotyrosine protein) phosphatases II 21-241 6.5e-18 60.4 In-house 13-169 (178) alignment 
Range on Protein: 21-241
Range on HMM: 13-169/178.0
DRAGSNNYINASFMSGYskknaFIATQMPLdstvLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTRsvtfgpftvghkgsenmnrvkvrtlelk
 .  .  |||||.. ..     ..... |      |...|.... |..|..|..        |  ||| ..                             
eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag............................

ykeevheirqfeVQTWPTWIQSDGVQSQEQCMDAVLQLMDYLRkceiqrsseqsrPGDGPPILVHCLSGIEESGVFCTVMNCLEQlnndgAIDVFQNLRL
            .|   . |  .||..  . ......... ..            . .| |.||||  |.  ||...    ....      ..... ..|
............iqylhipipDhgvpdllehflefvefieeal............dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

LRLSRPnFVPTLTDYLLCYKLLTH
.|  || .||.  ..  .|..  .
vrerRp.ivpnpgqlrqLyefelr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 21-211 2.3e-14 47.7 In-house 74-258 (310) alignment 
Range on Protein: 21-211
Range on HMM: 74-258/310.0
DRAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKgSENMNRVKVRTLELK
|..  ..|| | ..     ...|| .| ||. |..||||.. . |  .|..| .  ..    |  |||    . |.|   |    ||  .  ..  | . 
dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnl.sesseefeicnlavt

Y-------KEEVHEIRQFEVQ--TWPTWIQSdGVqSQEQCMDAVlqlmdylrkceiQRSSEQSRPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGA
.        |.  ..... |.   || | .  ||  .|.|                ||   | | |   | .||| .|..  .| ...   ...|..   
fvpdnvpvdeqpanlkelrvslikwpnwpdr.gv.pdekchtvp............qrllaqvrhg...pcvvhcsagkdrlyvvvalklkidkldrglk

IDV
.|.
vda
subfamily_PTPN6_pd Subfamily PTPN6 22-244 7.2e-34 112.2 In-house 77-298 (306) alignment 
Range on Protein: 22-244
Range on HMM: 77-298/306.0
RAGSNNYINASFMSGY--SKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLEL
    ..||||.....   ......||||  |..|| ||||.| .     |.|. . ...    |. ||| .... ..|  .| .  ...... ..|.| .
svpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsv

---KYKEEVHEIRQFEVQTWPtwiqSDGVQSQEQcmdAVLQLMDylrkcEIQRSSEQSRPGDGPPILVHCLSGIEESGVFCTV---MNCLEQLNNDGAID
   | |.| .|..|.. ..||      ||... .   |||....     ...| .|...  .  ||.||| .||   | |  .   .. .|.  .|  ||
skkkkkkeerevfqyhfksWP....dhgvpkdpg...avLdfle.....dvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadid

VFQNLRLLRLSRPNFVPTLTDYLLCYKLLTHHHT
. .  ...|  |  .| | . | . || ....  
iqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_PTPN14_pd Subfamily PTPN14 22-241 1.7e-32 107.6 In-house 72-294 (300) alignment 
Range on Protein: 22-241
Range on HMM: 72-294/300.0
RAGSNNYINASFMSG--YSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL--ND-KTCSIYWPVN---TRSVTFGPFTVGHKGSENMNRVKVRT
.  |..||||| ..    .|.  .|..| ||. || |||..| .  .. |.|| .   .  . .  |.| .    ..|.|| | |  | ||. ..|  ..
kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittg

LELKYKEEVHEIRQFEVQtWPTWiqsdgvqSQEQCMDAVLQLMDYLRKCEI-QRSSEQSRP--GDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAID
|.||.    .|   . .| .  |       ..... . | . ..||.. .  .| ......     ||.||||. |.  .||  ..   .. |...  ||
lklkhlpskeertvwhlq.ytDW.......pdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeid

VFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
. . |. ||  |  .|.||. |   ||.| .
ikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 22-134 1.6e-15 51.5 In-house 69-143 (392) alignment 
Range on Protein: 22-134
Range on HMM: 69-143/392.0
RAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKTcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkYKEE
    ..|.|||.. ..  ..|.||.|.|  ... ||||.|.. ...||.|...|..                                          ..
dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......................................kgdd

VHEIRQFEVQTWP
.. . || .  ||
artvaqfhftewP
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 22-84 1.5e-09 31.6 In-house 86-153 (349) alignment 
Range on Protein: 22-84
Range on HMM: 86-153/349.0
RAGSNNYINASFMS--GYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYW
 .  ..|||| ...   .| .. .||||.|| ||| ||....   ..  .. ||. ..   . | |||
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 22-135 2.6e-09 31.5 In-house 9-123 (130) alignment 
Range on Protein: 22-135
Range on HMM: 9-123/130.0
RAGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKtcSIYWPVNTRSV-TFGPFTVGHKGSENMNRVKVRTLELKYK-
|   |.||||||.    . . .. || ||  | .|||... .  .  ...|  ....    |||            .|     .... .|   || . . 
rlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee..deywpdsePlewyeediivtltdrdefknikasnleiesdl

-EEVHEIRQFEVQTWPT
 |  . .  |..  ||.
neshqaltmfqisnwps
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 22-78 4.5e-09 30.2 In-house 56-113 (332) alignment 
Range on Protein: 22-78
Range on HMM: 56-113/332.0
RAGSNNYINASFMSGYSKKNAFIATQMPL-DSTVLDFWRLVHDYRISTIIMLNQLNDK
. | ... |||.. |||||.|.| .| |. | |   |||.| . . | |... ....|
qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 23-239 1.3e-43 144.1 In-house 69-273 (315) alignment 
Range on Protein: 23-239
Range on HMM: 69-273/315.0
AGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL--NDK-TCSIYWPV-NTRSVTFGPFTVGHKGSENMNRVKVRTLELKY
   ..|||||.. .. . .|.||.|.||...| ||||.| .....||.|....  .||  |  |||  .. || || . |     |      .| | .. 
sPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrk

KEEVHEIRQFEVQTWPTwiqsDGVQSQEQcmdavlQLMDYLRKCEiqRSSEQsrpgDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLL
 || . . ||. . ||      ||. |         |. ....     . ..    .  ..||||..|.  .||.........|...  ..|||. .. |
seesrtvtqfqftewPd....kGvdkqts......sllklikevk..adngk....kefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknl

RLSRPNFVPTLTDYLLCYKLL
|  || .| |  .| . |  .
rakrpylvqteeeyafiydav
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 23-241 7.6e-40 131.5 In-house 67-291 (301) alignment 
Range on Protein: 23-241
Range on HMM: 67-291/301.0
AGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPV-NTRSVTFGPFTVGHKGSENMNRVKVR------
  ...|||||...|||.|..|||.| |...|. |||||. ... ..|.|. .|...    |  |||  ...| .||||||  . . ..    .|      
lcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvki

-----------TLELKYKEEVHEIRQFEVQTWPTwiqsDGVQSQEQcmdAVLQLMDYLrkceIQRsseQSRPGDGpPILVHCLSGIEESGVFCTVMNCLE
           ... | . . ... |..|  ||.    |||  . .    ||| .|      |.|   | ..| | |..|||  ..  |||.|.|   ||
qdgsnngyierkfkvksdksswdvlqlqvtdWpq....dGvvrepr...tvLqviddv....ihr...qqkiggg.pvvVHCSdtVsrsGvYcsvsiglE

QLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
|   .| .||||  . .| |.|  | ||  |   |. .. 
QckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
subfamily_PTPN23_pd Subfamily PTPN23 23-240 7.9e-33 108.5 In-house 64-277 (288) alignment 
Range on Protein: 23-240
Range on HMM: 64-277/288.0
AGSNNYINASFMSGYSKK-NAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL---NDKTCSIYWPVNT-RSVTFGPFTVGHKGSENMNRVKVRTLELK
 . ..||||||. . |     ||||| ||.||. |||..|.. . |.|.|| .    ... .. ||| .. ..|.||...|  |  .... .  |.|.|.
gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkle

YKE--EVHEIRQFEVQTWPTWiqsdGVQSQEqcmDAVLQLMDYLRKC-EIQRSSE-QsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNN-DGAIDVF
 ..  .|....  ....||      || .     . .||..|  ... | ..    .       |..|||..|.. .|||. |.  ...|.. .| .|. 
tldadavksvshlqltsWpel....GvPasP...etllqfldevesayeavqrkskt.......PlvvhCsaGvgRtgvfalvyaavrelekgnglldii

QNLRLLRLSRPNFVPTLTDYLLCYKLLT
| .. ||  | . | . . .  .|.   
qvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 23-241 3.2e-31 103.2 In-house 63-276 (287) alignment 
Range on Protein: 23-241
Range on HMM: 63-276/287.0
AGSnNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIML-NQLND--KTCSIYWPVNTRSVTFGPFTVGHKGSENMN-RVKVRTLELKY
 || .|||| ....| ...||||.| |. .|| ||||.| . | ...|..  ....  . |  ||| . . .  | ..|     ....    ||.| |  
lGs.dyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlid

KE--EVHEIRQFEVQTWPtwiqsDGVQSQeQCMDAVLQLMDYLRKCEIQRSSEQSrpgdGPpILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLR
 |  | . ..|... .||     |.| .   ..  .   .|  .. |..|....     || ..||.  ||  ||.. ... ....|.. | .|| . . 
letrearvvkqldllswP.....dkvlaP.tavglirfvldvkqhielardasev....GP.lvvhddvGiGrsGillatlvlvsrledlGrvdvaavvi

LLRLSRPNFVPTLTDYLLCYKLLT-H
 ||  |  .| .   . | |. |. .
rlreyraalvqavvqlrllyealvty
subfamily_PTPN13_pd Subfamily PTPN13 23-239 1.7e-29 97.9 In-house 57-265 (273) alignment 
Range on Protein: 23-239
Range on HMM: 57-265/273.0
AGSNNYINASFMSGYSKKNAF--IATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSV-TF-GPFTVGHKGSENMNRVKVRTLE
 .. .|||||..     |. .  ||.| ||  || |||..| . . . |.|. .  .|    |  |||.....  .  . ..|   . ....  .||.|.
gdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvrala

LKYK--EEVHEIRQFEVQTWPTwiqsDGVQSQEQcmdAVLQLMDYLRKceIQRSSEqsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQ
.| .  .|..|. ...  .||      || |. .    .||.. ..|.  .|...         ||.||| .||  ||.. |.   |. ...|  .|| .
vkdsesgesrevahlnfvkwPd....hgvPssaa...ellqfvaevrr..lqtdag........PivvhcsaGiGrsGtlitidvvlglierdkefdvke

NLRLLRLSRPNFVPTLTDYLLCYKLL
 .| ||  |   | |   |...|| .
ivrklreqrqgvvqtkdqyifvykai
0046846 (Phosphotyrosine protein) phosphatases II 23-238 3.5e-21 71.2 In-house 9-168 (176) alignment 
Range on Protein: 23-238
Range on HMM: 9-168/176.0
AGSNNYINASFMSGYskknAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVnT-RSVTfgpftvghkgsenmnrvkvrtlelky
 .. .||||... |.    ..|||| || .|. ||........|.....|...       |  |||.   .                             
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi..........................

keevheirqfevQTWPTWIQSDGVQSQEQCMDAVLQLMDYLrkceiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMncleQLNNDGAIDVFQNLRLL
            | . . .   || . |...... .. ..|               .| |.||||  ||  .|...        |  .  ..|.. |.|.
............qylhlpwpDhgvpdlelllellefireal..............keggpvlVHCsaGigRtgtlvaay....llelekglsveealalv

RLSRP-NFVPTLTDYLLCYKL
|  || . |.|   |  .|. 
reqRplgavqtpeQyrflyef
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 23-241 4.4e-18 59.9 In-house 63-267 (281) alignment 
Range on Protein: 23-241
Range on HMM: 63-267/281.0
AGSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL---NDKTCSIYWPVNTRS-VTFGPFTVGHKGSENMNRVKVRTLELKY
  | .|| | ..     |  .| || |   |  ||||.. .   ..|.|| |.   | . |. |.| |..  . |  ..| .. |   . .    |.| |
knstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy

KEEVHEIRQFEVQTWPTWIQSDgvqSQEqcmdAVlqlMDYLRKCEIqRSSeqsrpgdgPPIlVHCLSGIEESGVFCTVMNCLEQLNNDGAI-DVFQNLRL
. | . | ..  . || |   .   | |     .   .  |||    ||.        ||. .|| .|.  || . .|  .|. . .  .. |. | .  
egetrlithwlwkewpdwqvpe...sse....vm...lkilrkira.rst........ppv.ihcsagvgrsgtlmaveialqsihshftlpdikqivsh

LRL-SRPNFVPTLTDYLLCYKLLTH
||.  |   | || .|.| .|.|  
lrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 23-237 2.3e-13 44.5 In-house 77-283 (305) alignment 
Range on Protein: 23-237
Range on HMM: 77-283/305.0
AGSNNYINASFMSG-YSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQ---LNDKTCSIYWPVNT---RSVTFGPFTVGHKGSENMNR---VKVR
    .|| | ..      .. ||..| ||| |. .|| .| . ..  |.|| .   |    |. |||.     ...  |       ||  |.|   ... 
pspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqit

TLELKY-KEEVHEIRQFEVQTWPtwiqSDGVQsqeQCMDAVLQLMDYLRKCEIqrsseqsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDV
.|.| |  ..   .|...   ||      ||     |  . |.|.  .|  ..             ||.||| .||  .|   ..   ||.. ..     
llnltysgdqkmsvrhlqwtewp....drgvp...pckltslellsairgskv.............pivvhcsagigrtgtivaieyilekiaenkpcpp

FQN-LRLLRLSRPNFVPTLTDYLLCYK
. . .. ||  |   . .  .||  ..
mpelvkalrdqrafsiqndvqylfihr
subfamily_Ptp69D_pd Subfamily Ptp69D 24-252 1.8e-41 137.3 In-house 74-295 (307) alignment 
Range on Protein: 24-252
Range on HMM: 74-295/307.0
GSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNtRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE
 . .||||||. || .|. ||| | |...|. ||||.. .  . .|.|| .|..   | |. |||..   | .|   |    .|...    |.|..  |.
edsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkk

-------EVHEIRQFEVQTWPtwiqsDGVqsQEQCMDAVLQLMDYLRKCEIQRsseqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQ
       . ... |.. ..|.     |      ..  ..|.|.. .|. . .            ||.|||  | ..||.| ..   |.||...  .|.|.
eesgevedsrkvvqyhytgWk.....Dsk..vPevargllklieqvrelykln.........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife

NLRLLRLSRPNFVPTLTDYLLCYKLLTHHHTLCRSEEEL
  . ||  |. .|  |  |  .|. |  ...   ..|..
tvkdLrsqRnllvqsleqYvflyralldyssygdtdedv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 24-246 1.7e-37 123.8 In-house 55-268 (283) alignment 
Range on Protein: 24-246
Range on HMM: 55-268/283.0
GSNNYINASFMS---GYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNtRSVTFGPFTVGHKGSENMNRVKVRTLELK
 |..||||.|.     | ... .|..| ||| || |||..|.| .|..|.|| .| .   . || ||| .  |. .|.|||  .     |   .. | |.
esrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr.GsedyGeftvtlrkettsnsfiikelllr

YK---EEVHEIRQFEVQTWptwiqsdgvqsQEQCMDAVLQLM-DYLRKCEIQRSSEQSrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQ
..   ..   .  . |. |            |   .|..  .  . .    |. |...      ||.||| .||  ..||....  ....  .  .|||.
vnssakstlllahyqvidW...........leygeqaiinslvkfnkvislqteskkg......PivvhCstgiGrtavfiaasasvkdaltesvvdvfa

NLRLLRLSRPNFVPTLTDYLLCYKLLThHHTLC
 .. .|  |.  | ||  | | ..|    ..||
vvkimreqrmmavqtldqyklvhelvl.eqalc
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 24-243 7.3e-35 115.3 In-house 55-259 (267) alignment 
Range on Protein: 24-243
Range on HMM: 55-259/267.0
GSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKTCSIYWPVN-TRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEE-
  ..|||||.. || .|||||.|| ||. |. ||. ..||.....|..| .        .|| .  ..  .  .|| |   .. |  .. |||||.|.| 
keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknes

VHEIRQFEVQTWPtwiqsdgVQSQEQCmdAVLQLMDYLRKCEIQRsseqsrpGdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLS
 |..  .  . |        ......    .  |.  | | ...        | ..|..|.|  |.  || | ..   ||.. ..|  |.|. || .|  
ahnvtlyyykkwn.......intnnkp..ylkplfgilaknqlen.......g.nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsq

RPNFVPTLTDYLLCYKLLTHHH
|. .| |.  |. ...||... 
riglvdtkeryiyihellaeya
subfamily_PTPN3_pd Subfamily PTPN3 24-235 2.4e-29 97.1 In-house 63-268 (280) alignment 
Range on Protein: 24-235
Range on HMM: 63-268/280.0
GSNNYINASFMS----GYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLEL
....||||....    . .  | .|||| ||..|. |||..|.. ..|.|.|| .| ..    |  ||| .. ....| |.|  . ... . . .| | |
setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvl

KYKE--EVHEIRQFEVQTWPtwiqSDGVQSQEQcmdAVLQLMDYLRKCEiqrsseqsrPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQN
| ||  | ..| |.    ||      || ....    .|.... .||.           |.  |..||| .||. .||. ..  .|  ...  .. . . 
kdketkeerkilqlqylaWp....dhgvPddsa...dflefvervrklr.........sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldi

LRLLRLSRPNFVPTLTDYLL-C
.| .|  | ..|.| . | . |
vrtmrdqramlvqtasqykfvC
subfamily_PTPN1_pd Subfamily PTPN1 24-229 1.1e-25 84.9 In-house 54-257 (290) alignment 
Range on Protein: 24-229
Range on HMM: 54-257/290.0
GSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTR--SVTFG--PFTVGHKGSENMNRVKVRTLEL
..|.|||||..     |  .| || || .||  ||..| . .  ...|||.. .|    |  ||| . .  ....    ..|     |. .  .||.|||
adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllel

KY--KEEVHEIRQFEVQTWPTWiqsdGVQSqeqCMDAvlqLMDYLRKCeiqRSSEQSRPGDGPPiLVHCLSGIEESGVFCTVMNCLEQLNNDGA---IDV
.    .| .|| .|   ||| .    || .   .  |   ....| |.   |.|    .  ||. ..|| .||  || || |  || .... .    .|.
enlktqetreilhfhyttwpdf....gvpe...spaa...flkflfkv...resGslssdvGpa.vihcsaGiGrsGtfclvdtclvliekkddlssvdi

FQNLRLLRLSRPNFVPTL
 . |  ||  |  .. | 
kkvllelrkyrlGliqta
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 24-239 1.7e-23 77.7 In-house 79-279 (290) alignment 
Range on Protein: 24-239
Range on HMM: 79-279/290.0
GSNNYINASFMSGYskKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN-TRSVTFGPFTVGHKGS-ENMNRVKVRTLELKY
.  .|. | .. |   |  || || .| .||.|.||.| . ....|.|| .| .     |. |.| .  . .||| .||    . .. .... .|| .. 
ydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrd

KEE--VHEIRQFEVQTWPtwiqsDgvQSQEQCMDAVLQLMDYLRKCeiqrsseqsrPGdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLR
|..   | .. .....||     |  .|  .   |.|...  |||           .|   |. ||| .||  .| | ..  .|. | .  ..|. .  |
kdsGkehklkhlkikswp.....d..ksvalstlallrtlrilrka..........sG...pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvr

LLRLSRPNFVPTLTDYLLCYKLL
 || || | |   ..||.  ..|
alrnsrlnsvqvdiqylalveil
subfamily_PTPRN_pd Subfamily PTPRN 24-237 1e-20 68.6 In-house 82-286 (297) alignment 
Range on Protein: 24-237
Range on HMM: 82-286/297.0
GSNNYINASFMSGY-SKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTrSVTFGPFTVgHKGSENM--NRVKVRTLELK
 ...|||||..     .. |.|||| || ||| |||..| .  .  |..| .|..   | |. ||| .  | ... . | |  || .  .   ||.. ||
eksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG.sevyhiyev.hlvsehiwcddylvrsfylk

Y--KEEVHEIRQFEVQTWPtwiqSDGVQSQEQcmdavlQLMDYLRKCEiqrsseQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNND-GAIDVFQN
   ..|   . ||   .||    . || .. .       |... || .      .|  |   ||.||| .|   .||.. .   |..|..    ||.   
nlqtsetrtvtqfhflswp....eegvPasak......sllefrrkvn......ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaat

LRLLRLSRPNFVPTLTDYLLCYK
|  ||  ||..| |  .. ....
lehlrdqrpglvktkdqfefalt
subfamily_CG42327_pd Subfamily CG42327 24-166 6.9e-17 56.1 In-house 54-201 (319) alignment 
Range on Protein: 24-166
Range on HMM: 54-201/319.0
GSNNYINASFMSGYS-KKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKT---CSIYWPVNT---RSVTFGPFTVGHKGSENMNRVKVRTLEL
 ...|..||.. ||   .| .||.|..|...  ||||.| . .  .|. | .| ..    |. |.| .       ..| . |  || |  .|  . || |
dkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll

KYKEEvHEIRQFEvQTWPTWIQSDgVQSQEQ-CMDAVLQLMDYLRKCEIQR
|  .. .| |.     |  |.... | ..|.  .  .|.  . |.   ...
krvdk.eesrelt.hywykwleae.vPaeeaaliamllevrsslksysleq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 24-241 1.9e-14 48.4 In-house 65-275 (307) alignment 
Range on Protein: 24-241
Range on HMM: 65-275/307.0
GSNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVN-TRSVTFGP----FTVGHKGSENM----NRVKV
 . .|| | ..    | . ||..| ||..|. .|| .. . .. ..||| .. .     |  |||..  .  .||      .|   |....    . ..|
lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinv

RTLELKYKEEVHEIRQFEVQTWPtwiqSDGVQSqeQCMDAVlQLMDYLRkceiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQLN-NDGAID
 ||.... ..   |.... . ||      ||      . |.  |..  |             .|  |..||| .|.  ||   ..    ...       |
ttlkvdwaqksrtiqhlqwenwp....drgvpq..inltai.nlleavr.............ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckd

VFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
. . .. ||  |.  . |   ||  ...| .
mkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 24-240 6.8e-10 32.8 In-house 73-282 (302) alignment 
Range on Protein: 24-240
Range on HMM: 73-282/302.0
GSNNYINASFMSGYSKKNAFIATQMPLDSTV---LDFWRLVHDYRISTIIMLNQLNDK--TCSIYWPVNT-RSVTFGPFTVGHKGSENMNRVK-VRTLEL
  ..|.||| ..  . ..  | .|.|  ...    .|||.|.. .| .. .| . ..   | | ..| ..   ...| . |  .  |...  |   ..|.
epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEv

KyKEEVHEIRQFEVQTWPTWIQSDGVQSQEQCMDAVLQLmdylrkceiqrsSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLR
   |.. .    .|.    | |. . ... . . .. ..             ... ..|  ....    |.   |.| |..  .|.|... .  . . ..
l.PegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv............fakkikade.ntvivSknGaGRagafltlavaveklqkgkepnikeivk

LLRLSRPNFVPTLTDYLLCYKLLT
 .|  ||. | .|. |   |  | 
siRsqRpravdslkQyvslyiall
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 25-242 8.6e-49 161.0 In-house 36-241 (250) alignment 
Range on Protein: 25-242
Range on HMM: 36-241/250.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN--DKTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEV
  .||||||. ||....|||||| || .|. ||||.| .. ..||.||..|.  .||.. ||||.. . ..|  ||  . .|..  ...|.| |  ... 
esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvek.aekyGdvtvsllskeefadytkrklklskakka

HE--IRQFEVQTWPtwiqsDgvQSQEQCMDAVLQLMDylrkcEIQRSSEQSrpgDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRL
.|  .||..  .||     |  ..  . . |||.|..     ..|.| .|.   .  |..|.| .|.  || |...   ||.|...  .|||. .. || 
derivrqlhfvvWP.....d..kgvPevatavLellk.....kvqasqqqa...gnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrk

SRPNFVPTLTDYLLCYKLLTHH
 ||. | .|. |  .|... . 
drphavesleqyvfvyeiilka
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 25-239 8.7e-42 137.9 In-house 70-272 (515) alignment 
Range on Protein: 25-239
Range on HMM: 70-272/515.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL--NDKT-CSIYWPV-NTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE
 ..|.|||.. ..   .|.||.|.|....| |||||| .....||.|...|  .||  |. |||   . || || . |     |       |.|..   .
hsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgd

EVHEIRQFEVQTWPtwiqSDGVQSQeqcmdaVLQLMDYLRkcEIQRSSEQSRpgdgPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRL
... . ||. . ||      ||. .         |. ...  |.. . .|       |...||..|.   ||........ . ..  ..|||. .. .| 
dsrtvtqfhfteWP....dkGvpkh......tssllklik..evkadhgqyt....hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirq

SRPNFVPTLTDYLLCYKLL
 || .| |  .| . |  .
krpylvqtqeqyafiygav
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 25-249 5.6e-41 135.9 In-house 88-297 (319) alignment 
Range on Protein: 25-249
Range on HMM: 88-297/319.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNqlnDKTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKY---KEE
  .||||||..|| .|. .||.| ||| |. ||||.. .|..|||..|     . || ||| ..  .. . | |  .  |. .   || .||     ...
fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt...kdkcsqywplki.vikeerfkvkvdsveetaeyvvrdielsedgkekd

VHEIRQFEVQTWPTWIQSDgvqsqeqcmdAVLQLMDYLRKCEIQRSSEQSRpgdgPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLS
. .|.||  . ||   . |             .||  ..| .  .| |. |     .|.||| .|.  .||. ..   |......  .||.. .| ||  
irkitqfhflGwpdvGvpd..........ypsdlmrlvkkvrhltskenhr....anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqq

RPNFVPTLTDYLLCYKLLTHHHTLCRSE
|...|  |..| ..|  |  .| . .|.
rntlvqdlvqykfiysalleehlfghsd
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 25-238 9.2e-40 131.4 In-house 70-273 (287) alignment 
Range on Protein: 25-238
Range on HMM: 70-273/287.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPvNTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKE-
 ..||||.|. ||..|.|||... |. .|. .||.|..| ....|.|| |...   . |  ||| ...||..|....     | .. . .|.||.| |. 
hpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWp.eeksvvlGeyniellneevnagyierklevknknk

--EVHEIRQFEVQTWPtwiqSDGVQSQEQcmdAVLQLMDylrkceiQRSSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLL
  . ....|... .|.    | |  .. |   ..| ...       ..  .| ..|.. .|.|||  ..  |..|| .   ... ...|.||||| |.  
agdkqqvkqyqitnWd....stgkvtepq...tillvie.......emyktqrkrgnt.sivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksq

RLSRPNFVPTLTDYLLCYKL
|  .|. | | . |   ...
riqkpgsvqtveqykfindi
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 25-242 4.7e-36 119.2 In-house 47-263 (270) alignment 
Range on Protein: 25-242
Range on HMM: 47-263/270.0
SNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRS---VTFGPFTVGHKGSENMNRVKVRTLELK
  .|||| .. |... |...||.. ||..|. .|||.. . . ..|.|. .|..|    |. ||| .. .   ...|  .|    .|...   .. |.|.
ataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle

YKEEVHEIRQFEVQTWPtwiqSDGVQSQEQCMDAVLQLMDYLRKceIQRSSEQSRPGDgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRL
.| | ...  |  .|||     .|| ..|.      ||.  ||.  ..||... . ..  |.||||  |.. .|.. ..  ... |.... .|| . .. 
ekgeerrlvHfwyntWp....dhgvpreedsslstdqllkmlra..vrrsekeldkae..PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiiee

LRLSRPNFVPTLTDYLLCYKLLTHH
||  |...| .   | . || ....
lRkdRmalvqhpeqyeflykavvey
0043147 (Phosphotyrosine protein) phosphatases II 25-237 2e-25 84.9 In-house 4-155 (172) alignment 
Range on Protein: 25-237
Range on HMM: 4-155/172.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelK--YKEEV
...|||||....| . . ||||| ||..|. ||||..... |..|..|..|                                            .. ..
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpelle

HEIRQFEVQTWPtwiqSDGVQsQEQCMDAVLQLMDY--LRKCeiqrsseqsrpgdGPPILVHCLSGIEESGVFCTVMNCLeqlnndGAIDVFQNLRLLRL
... |.    ||      ||.   . .. .|...|   ...              | |.||||  |.  .|...    .|        ..... ..|.| 
rlgiqylylpwp....Dhgvp.llellleflefidellalsp.............ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvre

SRPNFVPTLTDYLLCYK
 ||. |..   | ..|.
kRpgavqnpsqyrflyy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 25-238 5.1e-25 82.8 In-house 75-274 (439) alignment 
Range on Protein: 25-238
Range on HMM: 75-274/439.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKTCsiYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEV--
   |||| .. || ... .||||.| . |. |||||| . . .||.|| .| .     ||| ..  | .|  .|      .. .  .| . .  . .   
hshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk..ywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdtte

--HEIRQFEVQTWPTwiqsDGVQSQEQcmdavlQLMDYLRKCEIQRSSEQSrpGdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRL
  . . ||   .||       | .|         ..|.||  .    .|.   |   |..||| .|.  .|   ..  .||||. .  .|.   ...|| 
kertvlqfhyiawpd....knvpaqas......hvldflrainsandkeey..g...pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrk

SRPNFVPTLTDYLLCYKL
 | ..| .| .|.. |. 
qrkqmvqalcqyvfiyna
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 25-238 8.2e-25 82.3 In-house 58-290 (297) alignment 
Range on Protein: 25-238
Range on HMM: 58-290/297.0
SNNYINASFMSGYS--KKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPV-NTRSVTFGPFTVGH--KGSENMNRVKVRTLEL
 ..|||| ..      ..  .| .| ||..|| |||.|| .  . .|.|. .|..     |  |||  .    . | . | .  . |.. .||..  |.|
erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelql

KYKEEVHEIRQFEVQTWPTWIQS----DGVQSQEQCM------DAVLQLMD-YLRKCEIQRSSEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNN
 |..|   .|  .  .||         | |. | |          .| |.. .     .|  | ..      ..|||| .|.  |||    .  |..| .
iyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrk

DGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKL
.   ||   |. ||  |.  | ||  . |.|..
kripdvaailsilreqrarlvqtleqfellyda
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 25-235 1.2e-19 65.4 In-house 34-232 (239) alignment 
Range on Protein: 25-235
Range on HMM: 34-232/239.0
SNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVNTRsvTFGPFTVGHKGSENMNRVKVRTLELKYKE
 ..|||||..  |    .|.||||  .  .  ||||.. . |   |.||  |     | |  ||| .|    .  . |  . .| .    .||. .    
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnlrvtlrktevfadyiirtfvmsqvg

EV--HEIRQFEVQTWPtwiqSDGVQsqeQCMDAVLQLMdylRKceIqrsSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLL
.   . . |. .  ||      ||    |   ||| |    ||  |   ...| ||   | ..|| .|.  .| |  .   | | ... ..|.|. .. .
qteeryvyqyhftvwp....dkgvp...qyatavlglr...rk..i...tkdslpgar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkai

RLSRPNFVPTLTDYLLC
|  || .| |  .|.. 
redrphmvqtseqyvfi
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 25-235 1.3e-19 65.4 In-house 35-233 (239) alignment 
Range on Protein: 25-235
Range on HMM: 35-233/239.0
SNNYINASFMSGYSK-KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLN---DKTCSIYWPVNTRsvTFGPFTVGHKGSENMNRVKVRTLELKYKE
 ..|||||..  |    .|.||||  .  .  ||||.. . |   |.||  |     | |  ||| .|    .  . |  . .| .    .||. .    
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnlrvtlrktevfadyiirtfvmsqvg

EV--HEIRQFEVQTWPtwiqSDGVQsqeQCMDAVLQLMdylRKceIqrsSEQSRPGDGpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLL
.   . . |. .  ||      ||    |   ||| |    ||  |   ...| ||   | ..|| .|.  .| |  .   | | ... ..|.|. .. .
qteeryvyqyhftvwp....dkgvp...qyatavlglr...rk..i...tkdslpgar.pwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkai

RLSRPNFVPTLTDYLLC
|  || .| |  .|.. 
redrphmvqtseqyvfi
subfamily_egg_pd Subfamily egg 25-255 3.8e-17 56.9 In-house 67-285 (307) alignment 
Range on Protein: 25-255
Range on HMM: 67-285/307.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND-KTCSIYWPVN-TRSVTF--GPFTVGHKGSENMNRVKVRTLELKYKE
....| |  ..|    | || .| ||  || ||||.|.  ..  |.||.   . . |  |||   . |. .  | . .   . ..      |  .||   
lddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvG

EVHEIRQFEvqTWptwiQSDgvqsqEQCMDAVLQLMDYLRKCeiqRssEQSRpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGA--IDVFQNLRLL
  .| |  |   |    | |      . .  |   .  |||    |  . |.     |..|..  |.  .... ..   | .|         | .   .|
gddeerfle..hw....qgd.....vnnssdvysplrvlrkl...r..nlsk.....pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvfl

RLSRPNFVPTLTDYLLCYKLLT-HHHTLCRSEEELDY--E
|| |.  | .   ||. |.|.    . .  | .|||   |
rlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdye
subfamily_eak_pd Subfamily eak 25-134 6.2e-13 42.8 In-house 77-190 (332) alignment 
Range on Protein: 25-134
Range on HMM: 77-190/332.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQ-LNDK--TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRVKVRTLELKYKE
 . ||||| .      . .| | .. .. |  ||..| . .  .|..| . .. |      |.| .||  . || . |  |   . | ...| |||.  .
rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGn

EVHEIRQFEVQTWP
| |..  ..|  | 
ethrvlhykvfGwt
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 25-226 5.1e-12 40.5 In-house 45-242 (290) alignment 
Range on Protein: 25-226
Range on HMM: 45-242/290.0
SNNYINASFMSgYSKKNAFIATQMPL-------DSTVLDFWRLVHDYRISTIIMLNQLNDK-------TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRV
...|| |.... ...  ..|.|| |.       .||. .|| .... ..  ..|| . ..|       .|. | | .   ...|. .||  |  |. . |
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

KVRTLELKYKEEV-HEIRQFEVQTWptwIQSdGVQSQEQCMdavLQLMDYLRkCeiqrsSeqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLN-NDG
..|.|..|. .|. . .    .. |    ..  || ... .   |.|..... .     |       . |..|||  ||  | .. ..      .    |
etRelvvkfddeeeftvtHsllkgW...nkl.nvqedtktl...lsliqkvk.a.....s.......ktpvivHcvdGiSrsAalaaiilgyQkiaetsg

AIDVFQNLRLLRLSRPNFV
.. . . |  ||  | . .
svkledvlkalrkqralai
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 25-135 7.2e-11 36.2 In-house 121-232 (244) alignment 
Range on Protein: 25-135
Range on HMM: 121-232/244.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKtcSIYWPVNTRSVTF-GPFTVGHKGSENMNRVKVRTLELKYK-EEV
.| ||||||.    .   .| || ||  | .|||... .  .  ...|  ....    |||       .    ||     ...  .|   ||..   .| 
gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee..deywpdseplewyeeditvtltdrdefknikasnleiesdmnes

H-EIRQFEVQTWPT
|  .  |..  ||.
hqaltmfqisnwps
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 25-87 1.2e-10 35.7 In-house 82-153 (350) alignment 
Range on Protein: 25-87
Range on HMM: 82-153/350.0
SNNYINASFMSGY----SKKNAF--IATQMPLDSTVLDFWRLVHDYRISTIIMLNQL---NDKTCSIYWPVN
.|.||||....      . .  |  |||| || ||| ||....    .  |..|...   | . | .||.  
tnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 25-73 9e-09 29.3 In-house 69-117 (347) alignment 
Range on Protein: 25-73
Range on HMM: 69-117/347.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLN
...||||| .     .. .| || || .|| |||..|.  ... .. . 
vetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 25-77 7.1e-06 19.9 In-house 66-118 (312) alignment 
Range on Protein: 25-77
Range on HMM: 66-118/312.0
SNNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND
 | || | |.   .| . |..|| ||..|.  ||.|.     ..||.|  . .
enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfve
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 26-249 6.1e-41 135.8 In-house 53-261 (284) alignment 
Range on Protein: 26-249
Range on HMM: 53-261/284.0
NNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNqlnDKTCSIYWPVNTrSVTFGPFTVGHKGSENMNRVKVRTLELKY---KEEV
 .||||||..|| .|. .|||| ||| |. ||||.. .|..|||..|    .. || ||| ..  .. . | |  .  |. .   || .||     ....
sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...kdkcsqywplki.vikeerfkvkvdsveeseeyvvrdielsedgkekdi

HEIRQFEVQTWPTWIQSDgvqsqeqcmdAVLQLMDYLRKCEIQRSSEQSRpgdgPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSR
 .||||  . ||   . |             .||  ..| .  .| |. |     .|.||| .|.  .||. ..   |......  .||.. .| ||  |
rkirqfhflgwpdvgvpd..........ypsdlmrlvkkvrhltskenhr....anivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqr

PNFVPTLTDYLLCYKLLTHHHTLCRSE
...|  |..| ..|  |  .| . .|.
ntlvqdlvqykfiysalleehlfghsd
0051429 (Phosphotyrosine protein) phosphatases II 26-241 9.9e-32 106.0 In-house 4-223 (272) alignment 
Range on Protein: 26-241
Range on HMM: 4-223/272.0
NNYINASFMSGYSK---KNAFIATQMPLDSTVLDFWRLvHDYRISTIIMLNQLN---DKTCSIYWP-----------VNTRSVTFGPFTVGHKGSENMNR
..||||....|| .   .........||. |. ||||| ....|.||..| ...      |. |||             . ....| ..| .   |... 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

VKVRTLELKYKEEVHEIRQFEVQTWPTWIQSDGVQsqeqcmDAVLQLMDYLRKceiqrsseqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGA
. .|.|.|...   .|.|.. . ..  |.     |      .|.|.|...|..              | |.|||| .|.  .|... .  .|.... .  
yilrellltlllsagearevmhlhytdwpdhgvpq......eallellellld..............ggpvlvHCsaGkdRTGtvvallllllgvsleti

ID--------VFQNLRLLRLSRPNFVPTLTDYLLCYKLLTH
.|        ... .. ||  ||..|.| . || .|. | .
vddYlltnlyleeaveelraqrpgavqteeqylflyealle
0036282 (Phosphotyrosine protein) phosphatases II 26-237 1.2e-26 88.9 In-house 2-164 (174) alignment 
Range on Protein: 26-237
Range on HMM: 2-164/174.0
NNYINASFMSGYSKKNAFIATQMPLDstvldFWRLVHDYRISTIIMLNQLNDKT---CSIYWPVntrsvtfgpftvghkgsenmnrvkvrtlelKYKEEV
..|||||.....   . .||.| ||.     ||.......|.|..||.... .    |  |||                               ... ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

HEIRQFEVQTWPTWIQSDGVQsQEQCMDAVLQLMdylrkceiqrsseqSRpGDGPPILVHCLSGIEESGVFCTVMNCLEQLNnDGAIDVFQNLRLLRLSR
... |.    ||     |  .  ......| . .              |. ..| |.||||  |.  .|...  . .| .|   ...|... .| ||| |
rlgiqylylpwpDhgvpdlsi.llefvkfveeal..............se.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqr

PNFVPTLTDYLLCYK
|. |.|   |  .|.
pgmvqtpsQyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 26-238 2.9e-21 71.1 In-house 3-148 (151) alignment 
Range on Protein: 26-238
Range on HMM: 3-148/151.0
NNYINASFMSGYskknaFIATQMPLDstvlDFWRLVHDYRISTIIMLNQLN-DKTCSIYWPVNTrsvtfgpftvghkgsenmnrvkvrtlelkykeevHE
..|||.|.. |.     ......||.    ||..|.... |.||..|...   ..|  |.| .                                   .|
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg..................................ie

IRQFEVQTWPTWIqsdgvqsQEQCMDAVLQLMDYLRKceiqrsseqsrpGDGPPILVHCLSGIEESGVFCTVMNCLEQlnndgaIDVFQNLRLLRLSRPN
.... .  ||.          ... ||||.....|..             .. |.|||| .|.  .|... .. .|..      ..... |. .||.||.
vlhipildwpdpg.......lplsfdavleflellld............kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpg

FVPTLTDYLLCYKL
.| . . .|.... 
vvqpnqqflfqlfa
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 26-240 9.4e-15 49.1 In-house 73-284 (305) alignment 
Range on Protein: 26-240
Range on HMM: 73-284/305.0
NNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTRSVTfgPFtvGHKGSEnMnRVKVR-TLELKYKEE
 .|| | ..|  .. . || || ||. |  ||| .  . .. .|.|| .| .|    |. |.. . . |    |    ||   .  ||.  . .||....
heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl..ef..eekgqk.i.svkfessvtlkfrkd

vheiRQFEVQTWPTWIQSDGVQSQEQCMDAVLQLMDYL---RKCEIQRSSEQSRPGDGPpILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQ-NLRL
     . .|.     |.  | ...        .  |         |    |..||  || | ||| .||  .|    .   |.|| .   |.  .  |. 
....akakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskgp.ivvhcsagigrtgsvvmleyildqllagqiiedtdkilqk

LRLSRPNFVPTLTDYLLCYKLLT
.|  | | . | ..||. .... 
ireqrnnsiqtdaqylfvhqvil
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 26-241 1.2e-12 42.5 In-house 67-269 (288) alignment 
Range on Protein: 26-241
Range on HMM: 67-269/288.0
NNYINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKT---CSIYWPVNT-RSVTFGPF-TVGHKGSENMNRVKVRTLeLKYKE
. ||.|  .|    |. .| .| ||..|.  .|... .  .  |.||..| .|       |.|..  ... .| . ||  |  ...... . .| |. ..
dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsl.lrisk

EVHEIRQFEVQTWPTWIQsDGVQSqeqcmdavlQLMDYLRKCEIQRSSEQsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRL
|..|     .  .  | . |||           . . .|| .|. .| ..       ||.||.  |.  .| .  ..  ||.|  |  . . . |  || 
egeekvivkilhlleWdd.dgvPe.........nylsplrllevlkslqk.......PivvhssaGvGrtgtlililialeslrlddflgirsllaklre

SRPNFVPTLTDYLLCYKLLTH
.| . . |   ||  .... .
erfkaiqtemqylyvhrcvle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 26-240 2.8e-11 37.9 In-house 59-267 (285) alignment 
Range on Protein: 26-240
Range on HMM: 59-267/285.0
NNYINASFMSGYSKK-NAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNT-RSVTFGPFTVG--HKGSENMNRVKVRTLELKY
 .|| ||.|    |  ...|.|| ||  |. |||..... .|. ..||  | .   . |..|.| .    | || . .       | .    . .| .  
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvin

KEEVHEIRQFEVQT-WPTWIqsDGVQSqEQcMDAVLQLMDYLRKCEIQRSseqsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRL
 |.      .  .   | |   | .   |.    ...|  ...| . .            || ||| .|.  .  |  .  .  .. ..  |.... .| 
tedasseplymnhvqvpwwp..dqlap.ed.arpmielykwvkkvnpkek..........picvhcsagvgrtatfvgidyatirimenpniemldivre

LRLSRPNFVPTLTDYLLCYKLLT
.|  | . | .  ..|. | .| 
mramrfqavqshmqflflyvvlm
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 26-242 2.4e-10 34.5 In-house 69-278 (303) alignment 
Range on Protein: 26-242
Range on HMM: 69-278/303.0
NNYINASFMSGYSKKNAfIATQMPLDSTVLDFWRLVHDYRISTIIML---NQLNDKTCSIYWPVNTRSVTFGPF--TVG-HKGSENMNRVKVRTLELKYK
  || ||..   |.|.| | ||.||  |  |||... . ..  ...|   .. ..      .| |   . |      ||  |  | ..  ... | .   
ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsng

EEVHEIRQFEVQTWPT-WIQSDGvqsQEQCMDAVLQLMDYLRKCeiqrsSeqsrpgDGPPILVHCLSGIEESGVFCTVMNCLEQL-NNDGAIDVFQNLRL
.    .     ..||   | |||     . .  . ||  .|||      |      |. | .   |||   .| |.    .   | ... ..|. . |  
dyksflhvhhykawphnsipsdg...spkfvkqiwqlqsvlrky.....s......dstptvymslsgcgragtfalfetahlslhseqasldlvkclen

LRLSRPNFVPTLTDYLLCYKLLTHH
.|  |   |  |... . | ||. |
vrngrlhavqnlsqfsvvytllaeh
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 28-227 4.8e-17 56.6 In-house 77-265 (301) alignment 
Range on Protein: 28-227
Range on HMM: 77-265/301.0
YINASFMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTR-SVTFGPFTVGHKGSENMNR--VKVRTLELKYKEE
 | | ...   . . ||||| ||..|  ||| ..  | . .|.|| |  .   . |. | ||... ..  | |..  | .| . .  .. ||||..   .
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

VHEIRQFEVQTWPTWIQSDGVQSQEQCMDavlqLMDYLRKCEiqrsseQsrpgdgpPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLS
  . |      . .| . .  .|  ...|    ||. ..| |      .       ||.||| .||  |  | .      ....|  |.. . |. ||  
kfatrtvthyqysewtdrgvPkshaelfd....lmelvkkse......k.......PivvhcsaGiGrsvafigteylareveadptieltealkhlreh

RPNFVP
| | | 
rwngvq
0049260 (Phosphotyrosine protein) phosphatases II 33-237 9.1e-22 72.8 In-house 1-144 (152) alignment 
Range on Protein: 33-237
Range on HMM: 1-144/152.0
FMSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfe
|..|| ....||||| |.. |. ||||..... |.||.||..| ..    |  |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

vQTWPTWIQSDGVQSQEQCMDAVLQLMDYLrkceiQ---RSseqsrpgdgpPILVHCLSGIEESGVFCTVMNCLeqlnndGAIDVFQNLRLLRLSRPNFV
 |   ...  .||.. .|... .|.... |     .               |.||||  |.  .|...    .|        ..... ..|.|  ||. |
.qylhlpwpDhgvpdlsqlllflllfiekl.....aldkgg..........pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgav

PTLTDYLLCYK
|.   . ..|.
pnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 34-245 1.7e-165 545.6 In-house 229-440 (440) alignment 
Range on Protein: 34-245
Range on HMM: 229-440/440.0
MSGYSKKNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQLNDKTCSIYWPVNTRSVTFGPFTVGHKGSENMNRVKVRTLELKYKEEVHEIRQFEVQTW
. ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtw

PTWIQSDGVQSQEQCMDAVLQLMDYLRKCEIQRSSEQSRPGDGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYL
||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyl

LCYKLLTHHHTL
||||||||||||
lcykllthhhtl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 40-237 5.7e-09 30.4 In-house 4-198 (199) alignment 
Range on Protein: 40-237
Range on HMM: 4-198/199.0
KNAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL--NDK-TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRVKVRTLELKYKEE----VHEIRQFEVQ
.  .|||| ||  |. |||..| .     |.|.|.   | .   ..|||.    .  .| ..|  |         . .| |  .        || ...  
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWptwiqsdgvqsQEQCMDAVLQLMDY-LRKCEIQRSSEQSRpgDgPPILVHCLSGIEESGVFCTVMNCLEQLN--NDGAIDVFQNLRLLRLSRPNFVPT
.|           .|.    |  .. . .   |. .  || .  |  |..|||  |   .||| ..   .   .  .   .|.|.  . || .|   . .
sw...........kekttpnvalfvgfvvasrevskkyeqek..d.apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss

LTDYLLCYK
|  | . |.
lqhynfiyq
subfamily_hpo-7_pd Subfamily hpo-7 40-227 8.1e-07 23.2 In-house 37-211 (263) alignment 
Range on Protein: 40-227
Range on HMM: 37-211/263.0
KNAFIAtqmpLDSTVLDFWRLVHDYRISTIIMLNQLNDK---TCSIYWPVNTR-SVTFGPFTVGHKGS--ENMNRVKVRTLELKYKEEVHEIRQFevqTW
|| ..     |  |.  |.. .   . ....||   |..    || |.|..      .   .|    .  . . . .. .  |. | ..|.....    .
knlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhy...sy

PTWIQSDGVQSQEQCMDaVLQLMDYLRKCEIQRSSEQSRPGDgppilvhclSGIEESgVFCTVMNCLEQLnNDGAIDVFQNLRLLRLSRPNFVP
  ||.  ... ... .  .|..   ... ..  |.   |              ..|. |. ...  |..  . . .|  . |. || ||.  ..
kgWiekndpelareiln.ilkvarnskslvvhcstGiGrsaa.........fsvaEl.vyqkmirsldtt.stveldylsLleelrssrkraih
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 41-237 6.3e-09 30.3 In-house 4-197 (198) alignment 
Range on Protein: 41-237
Range on HMM: 4-197/198.0
NAFIATQMPLDSTVLDFWRLVHDYRISTIIMLNQL--NDK-TCSIYWPVNTR-SVTFGPFTVGHKGSENMNRVKVRTLELKYKEE----VHEIRQFEVQT
  .|||| ||  |. |||..| .     |.|.|.   | .   ..|||.    .  .| ..|  |         . .| |  .        || ...  .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WptwiqsdgvqsQEQCMDAVLQLMDY-LRKCEIQRSSEQSRpgDgPPILVHCLSGIEESGVFCTVMNCLEQLN--NDGAIDVFQNLRLLRLSRPNFVPTL
|           .|.    |  .. . .   |. .  || .  |  |..|||  |   .||| ..   .   .  .   .|.|.  . || .|   . .|
w...........kekttpnvalfvgfvvasrevskkyeqek..d.apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl

TDYLLCYK
  | . |.
qhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 45-144 7.5e-06 20.2 In-house 39-134 (255) alignment 
Range on Protein: 45-144
Range on HMM: 39-134/255.0
AtqmpldsTVLDFWRLVHDYRISTIIMLNQLND---KTCSIYWPVNTR-SVTFGPFTVGHKG--SENMNRVKVRTLELKYKEEVHEIRQFEVQTWPtwiQ
        ||  |.. .   . ....||  ...   . || |.|..      .   .|      .. . |  . |..|  | . |... .. . |.   .
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWi...e

SDGVQS
  . . 
knaPel
0048076 (Phosphotyrosine protein) phosphatases II 99-240 8.9e-12 40.4 In-house 36-140 (145) alignment 
Range on Protein: 99-240
Range on HMM: 36-140/145.0
GhkgsenmnrvkvrtlelKYKEEVHEirQFEVQTWPTWIQSDGVQSQEQCMDAVLQLMDYLRKCeiqrsseqsrpgdGPPILVHCLSGIEESGVFCTVMN
                   . .| .|  .. .| . . .   ||..  . ....|.... ..|              | |.||||  |.  .|...  . 
l.................tselelle..rlgiqylylpwpDhgvpdllellleflefieealke.............ggpvlVHCsaGvgRtgtlvaayl

CLEqlnnDGaIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLLT
.|.     | ..... |.|.|  ||..||.   .  .|....
mll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 116-240 4.5e-17 56.5 In-house 271-382 (392) alignment 
Range on Protein: 116-240
Range on HMM: 271-382/392.0
LKYKEEVHEIRQFEVQTWPTWiQSDgvqsQEQCMDAVLQLMdylRKceIQRSSEQSRpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNL
..     | . |..   ||    ||    |..   ..|.|.   |   .. |... .      ||||||||   .||||| |.|. |. .  ..|.|| .
frslkashtvtqyqfhgwpkh.gsd....qqsgarsllkli...ra..vkgstnskk...efsilvhclsgagrtgvfctameciaqiaegdsvdifqtv

RLLRLSRPNFVPTLTDYLLCYKLLT
..||  | .|| |  .| . |..  
kilradrmqfvqteeeyafvydvir
PTPc_DSPc_SM00012 125-239 1.5e-17 59.1 In-house 2-103 (105) alignment 
Range on Protein: 125-239
Range on HMM: 2-103/105.0
IRQFEVQTWPTWiqsdGVQSQEqcmDAVLQLMDYLRKCEIQRSSeqsrpgdGPPILVHCLSGIEESGVFCTVMNCLEQLNND-GAIDVFQNLRLLRLSRP
...... .||      || ..    |..|.|.....|.. ...|       ..|..|||  |.  .|.|...  .|.||..  . .|.|| .. || .||
vkhyhytgwpdh....gvPees...dsilellravkknknkses.......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRp

NFVPTLTDYLLCYKLL
. | |...|| .|. |
gmvqteeqylflyral
0048179 (Phosphotyrosine protein) phosphatases II 130-237 3.4e-10 35.4 In-house 50-139 (144) alignment 
Range on Protein: 130-237
Range on HMM: 50-139/144.0
VQTWPTWIQSDGVQSQEQCMDAVLQLMDYLrkceiqrsseqsRPgDGPPILVHCLSGIEESGVFCTVMNCLeqlnNDGaIDVFQNLRLLRLSRPNFVPTL
.| . . .   || .  . ....|.... .            .. .| |.||||  |.  .|....   ..      | ..... |.|.|  ||. ||. 
iqylhlpwpDhgvpdllellleflefieea............le.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnp

TDYLLCYK
  .  ...
gqlrfLle
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 180-238 3.1e-07 24.7 In-house 2-60 (69) alignment 
Range on Protein: 180-238
Range on HMM: 2-60/69.0
LVHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKL
.||| ||   .| | ..|  . ..  .  .|.| |.. .|  ||  |    .|.. .  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 181-239 6.4e-07 23.6 In-house 2-60 (69) alignment 
Range on Protein: 181-239
Range on HMM: 2-60/69.0
VHCLSGIEESGVFCTVMNCLEQLNNDGAIDVFQNLRLLRLSRPNFVPTLTDYLLCYKLL
||| ||   .| | ..|  . ..  .  .|.| |.. .|  ||  |    .|.. .  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal