Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| 0045450 | (Phosphotyrosine protein) phosphatases II | 128-417 | 3.5e-82 | 271.9 | In-house | 4-304 (307) | alignment | ||
Range on Protein: 128-417
Range on HMM: 4-304/307.0
SLPGSIAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGI---AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDD-PHSDYYNANYI--------RDD
.| | ...|. .| .... . |.. || |.| . ..|..|||| |||.|.|...||.||.| .|... ..|||.||.|.
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy
KGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV-SGGETRSVHQFHY
. |..|||.|.| ...||||..|...| .||.|. | |. | ||| | | ..|.| . |.|. .|. .. ..|.| |. ||.| |..|||
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy
QSWPDMGVPQYPTTLISYTQTVKHVHERItantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESR---VDIFGFIQKMRKDRPNMVQTADQYILIHT
.|||.|||... .|.. . |....|. ....|.||||||||||||||| .| || |. .| ||.. ....|. ||..||. .||. ..
tgwpdhgvppsfeelldfieevrkaleel....pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye
ALVEAY
|| | .
allell
|
|||||||||
| subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 129-454 | 4.1e-203 | 668.5 | In-house | 1-325 (325) | alignment | ||
Range on Protein: 129-454
Range on HMM: 1-325/325.0
LPGSIAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPN
||||||||||||||||||||||||||||||||||||||||.|||||||||||||||.||.|.|||||||.||||.|||.||.|.||||.|..|.|||||.
lpgsiavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPl
TASINDFWRLI--WQenvCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYP
||.|||.|||. |. ||||.|.|.|..|||||.|||||||||||||||.|||||||||.||.||||||||||..||||||.||..|||.||||...|
tatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrp
TTLISYTQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPV
.||||..|.||.|.||.|||||.|||.||||||||||||.|||||..||.||||||||||||..|.|||||.||.|.||||||..|||||||||||||||
atlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpv
SSFEAKLSSLQERNPLTQKLNIEQEFEI
|||||||||||||||||||||||.||||
ssfeaklsslqernpltqklniekefei
|
|||||||||
| subfamily_Ptp69D_pd | Subfamily Ptp69D | 131-436 | 2.6e-82 | 271.4 | In-house | 2-305 (307) | alignment | ||
Range on Protein: 131-436
Range on HMM: 2-305/307.0
GSIAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDD-GIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNT
|.||...| | ....| . . |.|.|. |.. .|. | ||. |||...|.|||. ||.|.... . .||| ||..|. | ||.|||||.|
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve
ASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVS--G---GETRSVHQFHYQSWPDMGVPQ
| |.||||.|.. .| .||..|. | ...| |||.| . . .| | ||| |. ||...| ||| .. . ..| | |.||..|.|. ||.
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPe
YPTTLISYTQTVKHVHERItantkgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDV
...|. . . |..... .|..|||||||||.|.|..| .| |. .| .|||| .....|..|. .|| .||. .. ||.. . |.||.
vargllklieqvrelykln......rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtde
PVSSFEAKLSSL
| ..| .. .|
dvddledaierl
|
|||||||||
| subfamily_PTPRB_pd | Subfamily PTPRB | 132-420 | 3.9e-91 | 300.1 | In-house | 6-288 (293) | alignment | ||
Range on Protein: 132-420
Range on HMM: 6-288/293.0
SIAVVNLVEHVEKKKAQDQDGFAHEFGLLPS-DDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTA
| . .. |||.|.||... .|..|. | . . |...| ...|.||||..||...||||| |..|||...||| |||||.. . .. |||.| |
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe
SINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQvsGGETRSVHQFHYQSWPDMGVPQYPTTLI
...||||..|.... .||.|...|.|| .| |||.. .. ..| |.|.| . || .|.| | | ... . |.|.|.|.|..|||| |||. ..||.
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll
SYTQTVKHVHERitanTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSG
....||....|. |. ..|..||||||||||||||.| .| .. || |||||.....|..| ..||| .||| ||..... ...
dfvrtvreaiek....taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
|
|||||||||
| subfamily_PTPRD_pd | Subfamily PTPRD | 133-494 | 4e-123 | 407.0 | In-house | 5-357 (564) | alignment | ||
Range on Protein: 133-494
Range on HMM: 5-357/564.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
| | .| |||.| ||... | .|. . . . ...| ||.||||||..||||.|||||||.... |. ||| ||..| . .|..||.|.| .|
ipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti
NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmGkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISY
.||||..|..|....||.|.. | ||..| |||.. | ..|.|...|.| ||..| . | . .|. . |.| |.|||. |||| |||...|.|..
edFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl
TQTVKHVHEritantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAK
..|....| ... |..|||||||||||||| . .|| .. || |||.......||.|. |||| .||| ||.|..|| .|||.|........
irkvralne......pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqh
LSSLQERNPLTQKLNIEQEFEILNqLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCL
|. |.| .. |. ..|.||. |. . .. .. |..| | | .||||.|.|..|..| |
lqkLaeveedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilalescrvvl
|
|||||||||
| subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 133-454 | 5.2e-96 | 316.4 | In-house | 2-317 (318) | alignment | ||
Range on Protein: 133-454
Range on HMM: 2-317/318.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLL-PSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTAS
| | .| .||.. ... . . .|. | .|.. .... ...| ||||||. ||.|.||.|| |..|.... ||| ||||| . ||..|||||| .
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet
INDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLIS
|.||||..|. | . .||.|.. | ||... |||.. .|...| . |.|. |.||.| | . |.. |.| |.|.|| |||| |||. ...|..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslld
YTQTVKHVHeritaNTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEA
..|.... ...| .|..|||||||||||.|| . .| .. .|. ||.|......|. |. |||| |||..|...|.|| .||.|.| | . .
lvrqvskaq.....qksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrs
KLSSLQERNPLTQKLNIEQEFEI
.. |.|..| . . ... ||.
rirelreqdpesgttemdaefqr
|
|||||||||
| 0051299 | (Phosphotyrosine protein) phosphatases II | 133-417 | 1.5e-90 | 298.9 | In-house | 5-286 (288) | alignment | ||
Range on Protein: 133-417
Range on HMM: 5-286/288.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAK-TVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTAS
| | .|...|.|..| .. |.. || |.| . ..|..|||. |||...|...|||||.| .|.....|||.||.||. . |..|||.|.| .
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt
INDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKemGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV----SGGETRSVHQFHYQSWPDMGVPQYPT
..||||..|..|| .||.|.. | |. | ||| |.|.|.| | |.|. .|...| ..|.| |. . .||.| |..||| .|||.|||..|.
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe
TLISYTQTVKHVHEritantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAY
|... . |..... .|. |..|||||||||||||| |...| |. .| .||........|. ||.|||| .||.... ||.|..
llldflrlvrkala......sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
|
|||||||||
| subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 133-452 | 1.8e-90 | 298.2 | In-house | 5-318 (319) | alignment | ||
Range on Protein: 133-452
Range on HMM: 5-318/319.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
| | .| |.... ... . ....|| || . . | |.||| |||..||.|.|..|||| .|.. . ||| ||..| . .. |||.||| |
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti
NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGG-ETRSVHQFHYQSWPDMGVPQYPTTLIS
.||||..|.|.. |||.|.. | .| .. |||.| . ...| . |.| || .| . | | ... |. |||.| .|.|..||| .||.. |.|.
edfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslld
YTQTVKHVHERitantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEA
. ... .|. . | |. |||||||||||||| | || .| ||. .|.| .....| |. |||. .||..|. ||.|| .|.|.. | ..
llkrirksrek.....tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrd
KLSSLQERNPLTQKLNIEQEF
.| .|.|... | . .|.||
rlkqlaekvadtgetgleref
|
|||||||||
| subfamily_PTPRA_pd | Subfamily PTPRA | 133-452 | 3e-88 | 290.9 | In-house | 14-330 (330) | alignment | ||
Range on Protein: 133-452
Range on HMM: 14-330/330.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPS-DDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTAS
. | .| | .....|.| | || ||. . . .| | ||| |||. ||. .|.|||.| ... ..||| || .| | |..||||| | . .
lpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeet
INDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmGkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGE----TRSVHQFHYQSWPDMGVPQYPT
..||||.||. . ...||.|.. | ...|. |||.| | . |.| | |... .. | | . |.|.. . .| |.|||..||||.||| |
vedfwrmiweqksativmltelkerkeekcaqywPde.G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepi
TLISYTQTVKHVHERitantKGStPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVS
.... . ||..... ... |. |||||||||||||| | .|..| | .||.|.|....|. ||.|||| || .|. .| | |. |.|.. ||
Gmlkllkkvkklnqq.....sag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvs
SFEAKLSSLQERNPLTQKLNIEQEF
|.| .| .|... . |.| .|.||
slekhlqklynkitgtdkigleeef
|
|||||||||
| subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 133-437 | 4.1e-85 | 280.6 | In-house | 4-303 (305) | alignment | ||
Range on Protein: 133-437
Range on HMM: 4-303/305.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDdGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
||. .| ............|. ... .|... . . | | .||||||.|.|. .|..|. | . .....||| ||.|. |.||..|.||.| .
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv
NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQ-VSGGETRSVHQFHYQSWPDMGVPQYPTTLIS
.||||||..| | ..||.|.. |||||.| |||......| || ..|.|. ...||.. | | . . . |.|.| |.. .||| ||||..|.|.|
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls
YTQTVKHVHeritaNTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEA
. |.. . . .|.||||||||||||.||.. .| .. .| ||.|. ....|. |..|||| ||| .| || | .|.|.. .| ..|
likrvqkdq.....kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlra
KLSSLQ
.. |.
rvnklk
|
|||||||||
| subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 133-452 | 4.2e-84 | 277.1 | In-house | 6-314 (315) | alignment | ||
Range on Protein: 133-452
Range on HMM: 6-314/315.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
| . .|. .| .||| ..|| ... .| . || | ||| |||. ||.|.|.||| | |. |||||| |||.| . |. .||||.||.||.
ipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasv
NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgkSKTFGGIEVKLRTIEEFSDHVHRVLdvKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISY
.|||||...|.. .||.||. || | .. ||| . ..| | | .. | ... | | |.| . | | |.|| ||||||||.| ..|. .
kdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnl
TQTVKHVHERITantkgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAK
.||| |. ....||||||||||||||.| ..| |. | .|.. ||...|. | .|||.|.|| .|. ||.|... |.| . . .
irtvkqhhtnsv......gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqr
LSSLQERNPLTQKLNIEQEF
|| .| | ....|
ydsllapspdtgstllqeqf
|
|||||||||
| subfamily_PTPRK_pd | Subfamily PTPRK | 133-453 | 1e-81 | 269.2 | In-house | 4-313 (314) | alignment | ||
Range on Protein: 133-453
Range on HMM: 4-313/314.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDdgiaKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
| | .|.... . |. . || .|. |. .| | ||..|||...|.|.|.|||.| |...||.||| ||..| | . ||..| | .
irvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetv
NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVS--GGETRSVHQFHYQSWPDMGVPQYPTTLI
.|||||...|| .|.||.|.. | |. .|. |||.. ....| |.|.| | .. |.|.. |.... |.| |.||.. .||| .||.. |.|.
kdfWrlvydencasivmltelvevgrvkClkyWPed...tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgll
SYTQTVKHVHERitantkGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFE
.. . ||. .| . ...|||||| ||||||| . .| . .|. ||.| ....|. ..|||.| .||..|. ...|| . |.| .||| |.
klvrrvkksqee......eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefk
AKLSSLQERNPLTQKLNIEQEFE
| . .. .| |. ....||.
alylesirldpqtnssqlkeefq
|
|||||||||
| subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 133-419 | 1.6e-70 | 232.3 | In-house | 2-285 (290) | alignment | ||
Range on Protein: 133-419
Range on HMM: 2-285/290.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPSDD-GIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLK--DDPHSDYYNANYIRDDKGKKTFIAAQAPNT
| | .. |.|....|. ..|| ..|. | | . . ||.. ..|| .|||.||| | |..| . | .| || || . | || .||.|.| .
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs
ASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSG-GETRSVHQFHYQSWPDMG-VPQYPT
. |||.|||||.|. .||.||| | ||..| |||.. ..|..| ...|| |.... ..| |.||. . |...||.|.. ..|.. | |... |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt
TLISYTQTVKhvheriTANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMS
|..... .| | .| |...||||..|||...|.... . .. | .|.| ....| .|..|||..|| .|.. .... |
illvieemyk......tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
|
|||||||||
| subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 133-423 | 1.1e-66 | 219.8 | In-house | 2-284 (287) | alignment | ||
Range on Protein: 133-423
Range on HMM: 2-284/287.0
IAVVNLVEHVEKKKAQDQDGFAHEFGLLPS--DDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLEtlkdDPHSDYYNANYIRDDKGKKTFIAAQAPNTA
|.| .. | |.| .|. ..|| . | .| . .. |... ..|| |||...|. | ||.|. . | || || .| | || ||.|..| .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn
SINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVS-GGETRSVHQFHYQSWPDMG-VPQYPTT
. .||.||...|| .||... | .. | |||.| || ..| ...| | .. . | |.||. . |....|.|... .|.. | |... |
tarnfWkliddrnvtaivmlcqekendeevcyqyWpee..ksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti
LISYTQTVKhvheriTANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTD
|. . .| | .| |...||||..|||...|.. . .. .| .|.| ....| .|..|||..||. | ...| |..|
llvieemyk......tqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
|
|||||||||
| subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 133-213 | 5.5e-14 | 46.3 | In-house | 6-84 (440) | alignment | ||
Range on Protein: 133-213
Range on HMM: 6-84/440.0
IAVVNLVEHVEKKKaqDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIR
| |......|.... | |. |||| .| |.|| |||..||.|.|||||.|| .| |.||| || ||
iivadfadyvqnnr..rsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
|
|||||||||
| 0050432 | (Phosphotyrosine protein) phosphatases II | 134-422 | 5.4e-91 | 300.4 | In-house | 27-304 (308) | alignment | ||
Range on Protein: 134-422
Range on HMM: 27-304/308.0
AVVNLVEHVEKkkAQDQDGFAHEFGLLPSDDGIAK-TVAMKPENKAKNRFKNIVAFDHSRVVLetlkdDPHSDYYNANYIRDD--KGKKTFIAAQAPNTA
| .|....|| | | .. || |.| . . .||..|||| |||.|.|...|||||.| |..|||.||.|.. | ...|||.|.|
svldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpn
SINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMG-KSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTL
...||||..|..|| .||.|.. | |. | ||| |.| .|...|.. |.|. .|...|...|.| .. ...||.| |..||| .|||.|||..|. |
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeil
ISYTQTVKHVHeritantkGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNT
... . |.... .. |..|||||||||||||| |...| |. .| .||.|. ..|.|. ||.|||| .||.... ||.| ... |
ldflelvrksl........pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
|
|||||||||
| 0043336 | (Phosphotyrosine protein) phosphatases II | 134-415 | 2.8e-83 | 274.9 | In-house | 3-275 (278) | alignment | ||
Range on Protein: 134-415
Range on HMM: 3-275/278.0
AVVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASIN
| .|......... .. .. || |.| . . ...|..|||| |||.|.|...|||||.|. |. |..|||.||.|. . ...|||.|.|.. ...
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve
DFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPkemGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYT
||||..|...| ..||.|. | |. | ||| |.|.|.|.. |.|. .|...| ..|.| |. ||.| |...|| .|||.||| ...|...
dFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl
QTVKHVHEritantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
..|... | . ..|.||||||||||||||| || .| |. | .||.. ....|. ||..||| .||. .. || |
kavreale......dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
|
|||||||||
| subfamily_PTPRG_pd | Subfamily PTPRG | 134-430 | 2.1e-81 | 268.9 | In-house | 2-300 (563) | alignment | ||
Range on Protein: 134-430
Range on HMM: 2-300/563.0
AVVNLVEHVEKKKAQDQDGFAHEFG---LLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHS-DYYNANYIRDDKGKKTFIAAQAPNT
| ....|| . .|... ||..|| .. . . . ||||| ||| ||||.|.||| |. | . .. || ||||| . .| |||.| | .
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk
ASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKemGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV--SG----GETRSVHQFHYQSWPDMGVP
..||||.||..|| .||.||. | |. | ||||| .|.|.| ..|.| . | .. | | .|.. . . | |.|| .|||.|||
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP
QYPTTLISYTQTVkhvherITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTD
.... ... . .|| . |..||||||||||||.| | .| |. .|. |..|||....| |...||| .||| .| ||.|| .|..|.
ehslpvLifvkks......saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete
VPVSSFE
. . |
llaeqve
|
|||||||||
| subfamily_Sponge-PTP3_pd | Subfamily Sponge-PTP3 | 135-225 | 6.8e-12 | 39.4 | In-house | 7-94 (95) | alignment | ||
Range on Protein: 135-225
Range on HMM: 7-94/95.0
VVNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDdphSDYYNANYIRDDKGKKTFIAAQ
| . || . ... .. | || .. | . || | |||| ||. .| .|||| | .| ||| || .. |. .||||
vsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaq
|
|||||||||
| 0040438 | (Phosphotyrosine protein) phosphatases II | 136-453 | 4.3e-89 | 294.2 | In-house | 3-312 (317) | alignment | ||
Range on Protein: 136-453
Range on HMM: 3-312/317.0
VNLVEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDF
..|...... .. | .. || |.| . .||..|||| |||...|. .|||||.| |. |..|||.||.|. . |..|||.|.| ...||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF
WRLIWQENVCSVVMVTNILEGGKDRCTVYWPKemGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQT
||..|...|...||.|. | |. | ||| |...|.|.. |.|. .|| .. ..|.| |. ..|.| |..||| .|||.|||..|..|.. .
wrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea
VKHVHEritantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSS
|... | ....|.||||||||||||||| .|.|| |. .| .||.. ....|. ||..||| .||. ...|| | .. ..|..|.|.. ||
vreale......dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllk
LQERNPLTQKLNIEQEFE
|.. .|.. ..|.|..
lliplalddvklkekelk
|
|||||||||
| subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 136-416 | 9.6e-88 | 289.0 | In-house | 6-278 (288) | alignment | ||
Range on Protein: 136-416
Range on HMM: 6-278/288.0
VNLVEHVEKKKAQDQDGFAHEFGLL-PSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASIND
.. |..| ||.|....|| .|. | . . ..|.. ...|. |||..||...|. || |. |.. . .|| ||.|| ..|.||..||.|.|.....||
ispvakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvnd
FWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKqvSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQ
||.|...... .||.|...|||| .| |||.. .| | .| ..|.|. .| |.|.| | .. .. . ..|..|..|||.|||. . |. . .
fWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellr
TVKHVHERItantkgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
.|| .. . |..||||||||||||||.| ... .| || .|..|...|.|| |...||| ||. |. .|..
qvkvanqad......tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
|
|||||||||
| subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 137-424 | 2e-88 | 291.5 | In-house | 13-297 (298) | alignment | ||
Range on Protein: 137-424
Range on HMM: 13-297/298.0
NLVEHVEKKKAQDQDGFAHEFGLLPSDDG----IAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASI
| . ...||... |.|.|| | | |.|| ||||| |||. .|.|.|.||||||. ..| .||| || .. ||...|||.||| |...
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv
NDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISY
.||||....|.. ..||.||. | .| ... |||.| ...|.| |.|.|. |||.| . | | |.. . ..|.|.|.|. |||| |||.. |... .
edFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl
TQTVKHvheriTANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDV
. |. . . | .|..|.|||||||.|||| .. .| .| .|. ||.| .. .||.||..||| .||. |..| || |.|...
lrkvra.....sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
|
|||||||||
| subfamily_PTPN9_pd | Subfamily PTPN9 | 137-416 | 1.5e-71 | 235.9 | In-house | 5-289 (297) | alignment | ||
Range on Protein: 137-416
Range on HMM: 5-289/297.0
NLVEHVEKKkaqDQDGFAHEFGLLPSDDGIAKT-VAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDF
.||..|..| .. | .|. . . . ..... | |||..... .|..||||.....|..||| |||.. | ||.|||.| | ..||
elvayvkek...gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf
WRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQT
||..|...| .||.| ..| |. .|. |||.| ..|. || ..|. .|| .|...||| .|.| .|.|.| | . |||| |||. ..|. ..
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek
VKHV----HERITANTKGS---TPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
|.. . .....|| |..||||||.|||||||.| |... |.. ||.. ....|. | ..|| .|| . . |..|
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
|
|||||||||
| subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 138-417 | 4.5e-81 | 267.0 | In-house | 2-276 (281) | alignment | ||
Range on Protein: 138-417
Range on HMM: 2-276/281.0
LVEHVEKKKAQDQDGFAHEFGLLPS-DDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFW
| .|.......|. ||..|. | . . . . | . ..||. |||..||||.|..||... ... ..|| |||.. ||.| .||.|.| ||...||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW
RLIWQENVCSVVMVTNILEGGKDRCTVYWPkEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVkQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTV
...|...|. .||||. .|.|| .| ||| . .. ..| . || . || . ...|.. . . ..||||.|.|..|..||| |||. .. |... . |
qmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkev
KHVHERITAntkgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEE-SRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAY
....|. | .|...|||||||||||.|.| .. .| .| ...|. ....||.| |||| || .. |...|
lkltekktk.....aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
|
|||||||||
| subfamily_PTPN6_pd | Subfamily PTPN6 | 138-420 | 4.6e-77 | 254.0 | In-house | 12-299 (306) | alignment | ||
Range on Protein: 138-420
Range on HMM: 12-299/306.0
LVEHVEKK-KAQDQDGFAHEFGLLP---SDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLEtLKDDPHSDYYNANYIRD--DKGKKTFIAAQAPNTAS
|...||. . .. || || | . . . .. . ||||| |||.|||. |||.||.|. .. | ||| |||||.. . .|..||.| ..
rvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclett
INDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKtFGGIEVKLRTIEEFSDHVHRVLDVK-QVSGGETRSVHQFHYQSWPDMGVPQYPTTLI
..||||..|||| .||.|. .| ||..|. |||.| |.. .| |.|. . .. .| . | | |. . ...|.|.|.|.|..|||| |||. | ...
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL
SYTQTVKHVHERITANtkGSTPMLVHCSAGVGRTGTFISLYCMLAQVIE---ESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALvEAYMSG
.. ..|.. .|..... . |..||||||.||||||| . ..| .. . . .|| .....|. | .|||..|| ....|. ..|.
dfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai.kkyiet
|
|||||||||
| subfamily_PTPN23_pd | Subfamily PTPN23 | 138-415 | 1.6e-64 | 212.5 | In-house | 2-278 (288) | alignment | ||
Range on Protein: 138-415
Range on HMM: 2-278/288.0
LVEHVEKKKAQDQDGFAHEFGLLPSDDG---IAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDdphsDYYNANYIRDD-KGKKTFIAAQAPNTASIN
|||....|. ... .. ..| .| ... ...|. . |||...|. .||.||.|. || || || ...| | .|||.||| ..|
lveelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstln
DFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYT
|||...... . .||... | || .. |||.. |....|| ..| |. .| . ||.||| .. . ...|| ...|||..|||. | ||. .
DFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfl
QTVKHVHERITAntKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESR-VDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
. |.. .| | ||..|||||||||||.| .|. .... .. .|| ....|..| .|||. .|. | .|
devesayeavqr..ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
|
|||||||||
| subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 138-432 | 2.4e-60 | 199.2 | In-house | 7-294 (439) | alignment | ||
Range on Protein: 138-432
Range on HMM: 7-294/439.0
LVEHVEKKKAQDQDGFAHEFGLLPSDDG---IAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASIND
. ||||| . ..|. | ..| . | . ..| . ...|||.|...||||.||.|. . ||| |.|||||. .| .||.|.|. . .|
fqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettdd
FWRLIWQENVCSVVMVTNILEGGKdrctvYWPKEmgKSKTFGGIEVKLRTIEEFSDHVHRVLDV--KQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISY
||||...... .||.||..| | ||| . . .| | |. |. ..| | . | .. .. |.| |||| .||| || . .. .
fwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf
TQTVKHVHeritaNTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAK
.... ... |..|||||||||||| |.| | |. | .||| | .. .||.| .|||. ||..|. |..| . |.. | . |. .
lrainsan.....dkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkke
|
|||||||||
| subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 139-415 | 3.8e-40 | 132.5 | In-house | 10-285 (305) | alignment | ||
Range on Protein: 139-415
Range on HMM: 10-285/305.0
VEHVEKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKP-ENKAKNRFKNIVAFDHSRVVLETlkDDPHsDYYNANYIRDDKGKKTFIAAQAPNTASINDFWR
.. |.. . |. || . . . | |.| ... |||.|.. .|. || ||. || .| |||. | || .||| . |||
lkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkleg..pwph.eyihanyvstptnpkrfictqaplektcadfwy
LIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGG----IEVKLRTIEE--FSDH----VHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPT
. .|..| .. |. |.|| | .|. |.. . .. .| | ||. . .. | .. | . | . .|...| | ..|. ||| ||| .
mclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadl
TLISYTQTVKhvheritaNTKGstPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIF-GFIQKMRKDRPNMVQTADQYILIHTALVE
... . . .|| |. ||||||.||||. . | .| |... .. .||.|..| | .|| .||...| ...
ailellekar........pskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
|
|||||||||
| subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 141-437 | 4.7e-67 | 221.1 | In-house | 12-256 (392) | alignment | ||
Range on Protein: 141-437
Range on HMM: 12-256/392.0
HVEKKKaqDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIW
|||.. |..|| ||. | .||| |. |. |||.|||. .| .||.|| . | |.|||.|| ||. . .|..||.|.||.||..||||...
fveknr..hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvf
QENVCSVVMVTNILEGGkdrctvywpkemgksktfggievklrtieefsdhvhrvldvkqvSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVH
||||....|||.. || | ..|.| |||. ||| .||.. ..|. . . || .
qenvttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf
ERITantkgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQ
. | |...|||||||||| ||. ...|. . ||.| |. ..|. || |||| .|| .|. |..| . || .|| | .|. |.
Gqyt......hpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls
|
|||||||||
| 0039614 | (Phosphotyrosine protein) phosphatases II | 142-422 | 2.4e-82 | 272.0 | In-house | 23-294 (297) | alignment | ||
Range on Protein: 142-422
Range on HMM: 23-294/297.0
VEKKKAQDQDGFAHEFGLLPSDDGIaKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKD-DPHSDYYNANYIRDDKG-KKTFIAAQAPNTASINDFWRLI
. ..|| . .. || |.| ...|..|||| |||.|.|...|||||.| .... |..|||.||.|. . ...|||.|.|.. ...||||..
lllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv
WQENVCSVVMVTNILEGGKdRCTVYWPKEMGkskTFGGIEVKLRTIEEFSDHVHRVLDVKQvsGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHV
|...| ..||.|. | |. | ||| |.| |.|.. |.|...|. .. ..|.| |. .||.| |..|.| .|||.|||.....|.. . |...
weqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrea
HERItantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNT
... ....|.||||||||||||||| .| || |. .| .||.. ....|. ||..||| .||. .. ||.| .. ..|
lael....pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
|
|||||||||
| subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 143-419 | 3.7e-57 | 188.3 | In-house | 7-294 (301) | alignment | ||
Range on Protein: 143-419
Range on HMM: 7-294/301.0
EKKKAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKD--DPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIW
... |. ...|.... | . . || .. |||| ||||||. .|. |..|.. .. . .| ||.|| . . || |||||.| . |||||||
thvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw
QENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGE---------------TRSVHQFHYQSWPDMGVPQY
|| . |.||||| || |..|. |||. .|..|| ..|.| . |.| | | || | . ...| |.. .||. || .
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre
PTTLISYTQTVKHVHERItantkGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALvEAYMS
| | . . | | .| | |..||||..|.|.|...|. | |. | ||.|. .. .|. .| .|.| .||. |. .. . |..
prtvLqviddvihrqqki.....gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi.dmylq
|
|||||||||
| subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 145-215 | 7.7e-08 | 26.2 | In-house | 7-77 (244) | alignment | ||
Range on Protein: 145-215
Range on HMM: 7-77/244.0
KKAQDQDGFAHEF-GLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDpHSDYYNANYIRDD
. ||.. .|| || . .| |. | .|||. ||. ||..||.| . | . ||| |||||.
srlqdeevakeefvglsdhtreflqtnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqgs
|
|||||||||
| 0047943 | (Phosphotyrosine protein) phosphatases II | 146-416 | 9.6e-86 | 282.9 | In-house | 7-271 (273) | alignment | ||
Range on Protein: 146-416
Range on HMM: 7-271/273.0
KAQDQDGFAHEFGLLPSDDGIA-KTVAMKPENKAKNRFKNIVAFDHSRVVLetlkDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENV
|. . .... || ||.| . ..||..|||| |||.|.|...|||||.| .|..|||.||.|.. . |..|||.|.| ...||||..|..||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv
CSVVMVTNILEGGKDRCTVYWPKEMGK-SKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERI
.||.|.. | |. | ||| |.|. |.|.| . |.|. .|...|...|.| .. .. ||.| |..||| .|||.|||.... |... . |....| .
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal
TANtkgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
| .|..|||||||||||||| |...| |...| .||.. ....|. ||.|||| .||.... ||.|
psn....gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
|
|||||||||
| subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 146-453 | 5e-81 | 267.0 | In-house | 14-313 (315) | alignment | ||
Range on Protein: 146-453
Range on HMM: 14-313/315.0
KAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVC
| . |..|| || | ..|| ...| |||.|||. .|..||.|| . |.|.|||.|| ||. . |..||.|.|. ||..||||...||.|
knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvt
SVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLdVKQvSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHErita
..||||. || | .| |||.. ..| || |.|.| .| .| |.| | | . . |.| | ||... ||| ||.. ..|. . . || ..
tivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtr.kseesrtvtqfqftewPdkGvdkqtssllklikevkadng....
ntKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQERNPLTQK
| ..|||||||||||| .||. ..||. ... ||.| |....|..|| .||| ..| .|. |. | . || ..| | .| |. . .
..kkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgr
LNIEQEFE
.. .|||
skmtkefe
|
|||||||||
| subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 146-430 | 1.7e-76 | 252.2 | In-house | 21-297 (297) | alignment | ||
Range on Protein: 146-430
Range on HMM: 21-297/297.0
KAQDQDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGkkTFIAAQAPNTASINDFWRLIWQENVC
| .. | | .|| ||. ..||| | | |.|.|||. .| ||| |. . ||| ||| || ... | .|. | |. |...|||.....|.|
knrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvs
SVVMVTNILEGGKdRCTVYWPKEMgkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQ--YPTTLISYTQTVKHVHERi
.||... |. | .|. ||... ..||| . |.| ...| . ..| |.|.. . .| |.|... .||| |.. ..|. . . |.....
tivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsq.
taNTKGstPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFE
|..| |.||||.||||||| .... ..|.. .| |||||...|.|..||..||| .|| ... |..|| .| .|....| ||
..naeg..PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyfe
|
|||||||||
| subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 150-461 | 5.2e-85 | 280.5 | In-house | 17-320 (515) | alignment | ||
Range on Protein: 150-461
Range on HMM: 17-320/515.0
QDGFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVM
|. || || . .||| . | |||.|||. .| .|| || ..|.|||||.|| ||. . |..||.|.|| ||..|||||..|||| ..|
ttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiam
VTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVkqVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITantkg
||. || | .|. |||. |.| || |.|.| ..| .. . | | | . | ..| | |||.. ||| |||. ..|. . . || |...|
vtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.....
sTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQERNPLTQKLNIE
|...|||||||||| .||. ..|.. . ||.| |....|..|| .||| .|| .|. |. | . || .|| | .| |. . ..
.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmt
QEFEILNQLTPP
.||. |. |.|
kefqtlkslcpd
|
|||||||||
| subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 150-438 | 9.2e-76 | 250.2 | In-house | 33-312 (319) | alignment | ||
Range on Protein: 150-438
Range on HMM: 33-312/319.0
QDGFAHEFGLLPS--DDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSV
. . || .. .. .| | ..|| |||. ||.|||...| || | ||| || .. . |. .|||| | ...||||.||. |....
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti
VMVTnileggKDRCTVYWPKEMgkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQ-VSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitan
|..| ||.|. |||... .. . .||. ..|| ...| | ... . . |...|||.. |||.|||.||. |. . |.|....
vllt......kdkcsqywplki..vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk....
TKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQE
.. ....|||||||||||..| | ..| .. ||..||.. |.. .|..|...|| || .|..||.| .. |..|| . | | | | .
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsn
|
|||||||||
| subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 150-415 | 1e-40 | 134.2 | In-house | 10-267 (281) | alignment | ||
Range on Protein: 150-415
Range on HMM: 10-267/281.0
QDGFAHEFGLLPSDDGIA-KTVAMKPENKAKNRFKNIVAFDHSRVVLET-LKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSV
| | .|| || | || .| |. |||. || ..| ||| |. . . .|| ||||| |. .| .| |. . ||||.||||| ..
lddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai
VMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKqvSGGETRSVHQFHYQSWPDMGVPQYPTTLIsytqtvkHVHERITANt
||. ..|| ...|. |.|.. | . |. | |.. |||| . .. .. ||| ||. .. .. .| |
vmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls..yegetrlithwlwkewpdwqvpessevml.......kilrkirar.
kgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEE-SRVDIFGFIQKMRK-DRPNMVQTADQYILIHTALVE
||| ..||||||||.||.... | . . || . ..| | ||| .||.|| |..
..stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
|
|||||||||
| subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 152-425 | 1.1e-34 | 114.4 | In-house | 28-297 (310) | alignment | ||
Range on Protein: 152-425
Range on HMM: 28-297/310.0
GFAHEFGLLPSDDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETlKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVT
|..... | ... . | .. |||. ..| | ||| |. . || |||.. . ..||| .| | .| ||||.|.|| |....
glvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklki.dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc
NILEGGKDRCTVYWPKeMGKSKTFGGIEVKL--RTIEEFSD---HVHRVLDV----KQVSGGETRSVHQFHYQSWPDMGVPQypttlisytQTVKHVHER
.. | |. .| ||| .| ..|.| | | . ||| | | | .| . . | .. |||.|||. . .. | .|
kvgeegrpkcvgywps.lgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd.........ekchtvpqr
ITANTKgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVeAYMSGNTDVP
. |. . | .||||||..|... ..| . .. . .||. . ...|.| .|| ||..|. . .. |.|.|
llaqvr.hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargeteva
|
|||||||||
| subfamily_CG42327_pd | Subfamily CG42327 | 153-337 | 3.9e-31 | 102.9 | In-house | 7-191 (319) | alignment | ||
Range on Protein: 153-337
Range on HMM: 7-191/319.0
FAHEFGLLPsdDGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRD-DKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVT
| || || ||.. .. . | |.|. |.| . ..||||. ||... | .|.|.| |. . .||||.. | ||||..|. . .| .|
vaeefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt
NILEGGKDRCTVYWPKEMGK--SKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYqSWPDMGVPQYPTTLISYTQTVK
.. | | ..|. |.| . . ...| | | |. | .. | .|.| . |.| . . | |.. .|| ...||. |.
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
|
|||||||||
| subfamily_ptpA1_pd | Subfamily ptpA1 | 154-375 | 9e-39 | 128.4 | In-house | 24-254 (418) | alignment | ||
Range on Protein: 154-375
Range on HMM: 24-254/418.0
AHEFGLLPSDDGIAKTV-AMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIrDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTN
|| || | ..| | | .|||. ||. .|.|| |. ..| ||| ||||| | | ||..| | .| ||||..|.. . .||..
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi.dgaypkqfictqgplpntiadfwrmvwenrcriivmlsr
ILEGGKDRCTVYWPKEMGKS---------KTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERI
| . .| |||...| . || |.| . . .. ... |||| . |..|. ||| .|.. . ... ...|
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqi
TANTKGSTPMLVHCSAGVGRTGTFISLYCMLA
.. |..||||||||||||| . |.
ipssdrnvpiivhcsagvgrtgtfctavimmk
|
|||||||||
| subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 156-415 | 2.2e-67 | 222.0 | In-house | 10-266 (274) | alignment | ||
Range on Protein: 156-415
Range on HMM: 10-266/274.0
EFGLLPSDDgiAKTVAMKPENKAKNRFKNIVAFDHSRVVLET-LKDDPHSDYYNANYIRD-DKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNI
|| ||.. . . . .. |||.|.|. ..|||.||. .|. |.| |||||. |. .|...|.| | . ..||||.|.||.| .||.|..
eflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltkl
LEGGKDRCTVYWPKEMGK--SKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGgeTRSVHQFHYQSWPDMGVPQYPTTLIsytQTVKHVHERITANTKGST
| ...|.||.|.. . |...|..|.| . | | |. | | .|... .|||. . | .|||. .|. ..||. ..|..|.| ..... .
keaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantll...dlvleveesreeenakla
PMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
|..||||||.|||| ||. . |. ||. ||... . ..| || ||||..|| ||| ||..
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
|
|||||||||
| subfamily_PTPN3_pd | Subfamily PTPN3 | 164-419 | 9.1e-62 | 203.5 | In-house | 29-277 (280) | alignment | ||
Range on Protein: 164-419
Range on HMM: 29-277/280.0
DGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLEtlkDDPHsDYYNANYIRDDKGK----KTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKD
|.| ..| |||| .|||...|...|. || |. . . || ||||. . . .||.| | . . .|||...|.... .||.|...| |.
pglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv
RCTVYWPKeMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHeritanTKGSTPMLVHCSA
.| |||. .... ..|...||.. .| . .| | | .|. . | |...|. | .||| |||. .. .......|.... . ..|..|||||
kChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr......sgkeePvvvhCsa
GVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMS
|.|||| .| | || . .. | . ...|| | ..||||.|| .. |....|.
GigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
|
|||||||||
| subfamily_PTPRN_pd | Subfamily PTPRN | 164-415 | 4.6e-54 | 178.1 | In-house | 44-290 (297) | alignment | ||
Range on Protein: 164-415
Range on HMM: 44-290/297.0
DGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKG-KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCT
. .|.|| ...| ||| |.....||||| |.. .. .||| || | |. . ..||.|.| .... |||...|.. |. .|..|.. | | .|.
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck
VYWPKEmGkSKTFGGIEVKLRTIEEFS-DHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitantkGSTPMLVHCSAGV
|||.| | |.... ||.| . .. |.. | . .|.. |||.| |||. |||..||| . .|. . . | . |.|..||||.|.
rywpde.G.sevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG......rscpivvhcsdGa
GRTGTFISLYCMLAQVIEES-RVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
||||..| . .|.... ..|| ....| .||..|.| ||. .. ||..|
GrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
|
|||||||||
| subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 164-407 | 4.4e-31 | 102.8 | In-house | 40-271 (301) | alignment | ||
Range on Protein: 164-407
Range on HMM: 40-271/301.0
DGIAKTVAMKPENkaKNRFKNIvAFDHsRVVLETLKDDPHSdYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTV
| | .. | |.. |.|.... . .| ..| ||.| . . |||.|.| ... .||| .. | .| .||... .| ...|.
dhitesyaylpkd..khryptv.PckP.stavevivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekcee
YWPKEMGKSKTFGGIEVKLRTIEEFS-D-HVHRVLDVKQVSGG-ETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKhvheritantKGSTPMLVHCSAG
| | ..... | ..|... | . ..| |.|. .| .||.| . |..|.| |||. . | . || | |..||||||
ylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk..........ksekPivvhcsaG
VGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYI
.||. .||. .. .| . .... ....|..| | ||| |
iGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
|
|||||||||
| subfamily_egg_pd | Subfamily egg | 164-414 | 6.5e-31 | 102.1 | In-house | 28-267 (307) | alignment | ||
Range on Protein: 164-414
Range on HMM: 28-267/307.0
DGIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGgkDRCTV
| |. | |.. .|. | | | . | ||| || . |. ||... . .|| |||| . .||||...||.| .||.| | .||
deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey
YWPKEMGKSKTF--GGIEVKLRTIEEFSDHVHRVLDVKQvSGGETRSVHQFHYQSwpDMgvpQYPTTLISYTQTVKHVHeritantKGSTPMLVHCSAGV
|||| .| . |..... ... .| . || .| ||. . |.| |. .. . . | . .... . |.|..|.. ||
ywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg..dv...nnssdvysplrvlrklr.......nlskpvvvqdilGv
GRTGTFISLYCMLAQVIEE--SRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
...|.... | ... . . .. .|. |. |... .|.... ..
skaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
|
|||||||||
| subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 165-438 | 1.1e-74 | 246.5 | In-house | 14-276 (284) | alignment | ||
Range on Protein: 165-438
Range on HMM: 14-276/284.0
GIAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTnileggKDRCTVY
| .| | ..|| |||. .|.|||...| || | ||| || .| . |. .||.| | ...||||.||. |....|..| ||.|. |
gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy
WPKEMgkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQ-VSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitanTKGSTPMLVHCSAGVGR
||... .. . .||. ..|| ...| | ... . . |...|||.. |||.|||.||. |. . |.|.... .. ....|||||||||
wplki..vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk....enhranivvhcsagvgr
TGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQE
||..| | ..| .. ||..||.. |....|..|...|| || .|..||.| .. |..|| . | | | | .
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsn
|
|||||||||
| subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 165-415 | 8.7e-43 | 141.2 | In-house | 24-257 (267) | alignment | ||
Range on Protein: 165-415
Range on HMM: 24-257/267.0
GIAKTVAMKpeNKAKNRFKNIVAFDHSRVVLETLKDDphsdYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNIlegGKDRCTVY
|.. .|.| |...||. . . .|..||.| | ... | || |. | |..||. | | .| ||. .| ...| .|..|.. ..| .
tisqsiaek..nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlf
WPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSgGETRSVHQFHYQSWpDMGVPQYPttlisYTQTVKHVHERITaNTKGSTPMLVHCSAGVGRT
|| .||..| . . |. .| |. .|..| .. | ..|. | .. . . | | . . . . .|. |..|.||.||||.
wPPkmgqakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkw.nintnnkp.....ylkplfgilaknq.lengnrPlvvacsdGvGrs
GTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
|||. .. .| .. .|. .||| |..|.|. |. .|.| ..|| || |.|
Gtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
|
|||||||||
| 0046845 | (Phosphotyrosine protein) phosphatases II | 166-423 | 4.1e-88 | 290.7 | In-house | 15-280 (284) | alignment | ||
Range on Protein: 166-423
Range on HMM: 15-280/284.0
I---AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDD-PHSDYYNANYIRDD-----KGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEG
.||..|||. |||.|.|...|||||.| .|..| ..|||.||.|.. . ||.|||.|.| ...||||..|..|| .||.|.. |
klllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelven
GKDRCTVYWPKEmGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVS-GGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitanTKGSTPMLV
|. | ||| | |...|.|.. |.|. .|...|...|.| .. .. .||.| |..||| ||||.|||..|. |... ..|....|. ..|. |..|
grekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen....lpgggpivV
HCSAGVGRTGTFISLYCMLAQVIEES---RVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTD
||||||||||||| |...| |...|. .||... ....|. ||.|||| .||.... ||.|......|
HCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
|
|||||||||
| subfamily_PTPN12_pd | Subfamily PTPN12 | 166-416 | 4.1e-79 | 260.5 | In-house | 30-276 (290) | alignment | ||
Range on Protein: 166-416
Range on HMM: 30-276/290.0
IAKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYW
. .... |.||..|||.|.|. .|.|||.|.. .....||| |||.|. .||...||||.| .. ..||||.||. || |||. ...| || .| ||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW
PKEMGKSKTFGGIEVKLRTIEEFS-DHVHRVLDVKQVsgGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHEritantKGSTPMLVHCSAGVGRT
|.|.... .|| .||.| . . .. |.. | | |.. .|.|.|.||||..||| |||. ...|.. ...|....| . ..|..||||||||||
peegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe......sedaPlvvhCsaGvGrt
GTFISLYC---MLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
|| |.. .| . . ....|.| ....||.|. .||| .|| |.. |..|
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
|
|||||||||
| 0036941 | (Phosphotyrosine protein) phosphatases II | 167-427 | 3.9e-88 | 290.9 | In-house | 30-287 (297) | alignment | ||
Range on Protein: 167-427
Range on HMM: 30-287/297.0
AKTVAMKPENKAKNRFKNIVAFDHSRVVLetlkDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWP
..||..|||. |||.|.|...||.||.| ||..|||.||.|. . |..|||.|.| ...||||..|..|| ..||.|. | |. | |||
slsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywp
KEMGKSKTFGGIEVKLRTIEE--FSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERItantKGSTPMLVHCSAGVGRT
|.|.|.|.|.. |.|...|. ..| . |.| |. . .||.| |..||| .|||.|||..|..|... . |..|.. . ...|.||||||||||.
leegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll....psggpvlVHCsaGvgRs
GTFISLYCMLAQVI---EESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVPVS
|||| ...|| |. .| .|||. ...|.|. ||..||| .||. .. || | .....|..|..
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll
|
|||||||||
| DSPc_SM00195 | 167-417 | 4.5e-83 | 273.9 | In-house | 17-262 (263) | alignment | |||
Range on Protein: 167-417
Range on HMM: 17-262/263.0
AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWP
.| | |..||.|||.|||. .||.|| |.. .....|||.|||||. .. ||..||.|.| ..||||..|.|.| .||.|. | || .|. |||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp
KEMGKSKTFGGIEVKLRTIEEFS-DHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERItantkgSTPMLVHCSAGVGRTG
.|.|...||| |.|||. |. . . . |.| ... |||.|.|..|..||| |||. .. .... ..||. .... |.|..|||||||||||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts......sgpivVhCsaGvgRtg
TFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAY
||... ..| .. ||..|||| ....|| ||.|||| .||. |..|..|..
tfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
| PTPc_SM00194 | 167-417 | 4.5e-83 | 273.9 | In-house | 17-262 (263) | alignment | |||
Range on Protein: 167-417
Range on HMM: 17-262/263.0
AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWP
.| | |..||.|||.|||. .||.|| |.. .....|||.|||||. .. ||..||.|.| ..||||..|.|.| .||.|. | || .|. |||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp
KEMGKSKTFGGIEVKLRTIEEFS-DHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERItantkgSTPMLVHCSAGVGRTG
.|.|...||| |.|||. |. . . . |.| ... |||.|.|..|..||| |||. .. .... ..||. .... |.|..|||||||||||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts......sgpivVhCsaGvgRtg
TFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAY
||... ..| .. ||..|||| ....|| ||.|||| .||. |..|..|..
tfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
| subfamily_PTPN14_pd | Subfamily PTPN14 | 167-415 | 1.5e-56 | 186.6 | In-house | 40-294 (300) | alignment | ||
Range on Protein: 167-415
Range on HMM: 40-294/300.0
AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDpHSDYYNANYIRDDKG--KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVY
..| |||. |||||... ....|| | . |.. ...| || |. | ....|.||.| ..|||...|...| .||.|.. |.||... |
llstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky
WPKE--MGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITANTK---GSTPMLVHCSA
.||. |. .|| .| . |. . . . | .| . .| |.|. . |. ||| |||. ... .|| . |. | .. . ... . |.||||||
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsa
GVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
|||||| | ..| . . ..|| ....|. | .||| || ....|..
GvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
|
|||||||||
| subfamily_PTPN1_pd | Subfamily PTPN1 | 167-418 | 4.3e-56 | 184.8 | In-house | 23-272 (290) | alignment | ||
Range on Protein: 167-418
Range on HMM: 23-272/290.0
AKTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDdphsDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWP
..| .|||...||.... .||||..|| . || ||. . .. |. .| .| | . .. ||...|... .|||. ...| .. .|. |||
ptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP
KEMG-KSKTFG--GIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVheriTANTKGSTPMLVHCSAGVGR
.. |. .. ..||| . |. | .. |.|...... |||.. .||| .|||.|||. |...... . |.. . .. | ..|||||.||
qgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvres....GslssdvGpavihcsaGiGr
TGTFISLYCMLAQVIEESR---VDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
.|||. . ..|... .. ||| . ..|| | ..||||| . ..|..|
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
|
|||||||||
| 0045098 | (Phosphotyrosine protein) phosphatases II | 168-418 | 6.2e-74 | 244.2 | In-house | 25-273 (278) | alignment | ||
Range on Protein: 168-418
Range on HMM: 25-273/278.0
KTVAMKPENKAKNRFKNIVAFDHSRVVletlkddphsDYYNANYIRDDkgKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPk
|.|....|..|||.|.|...|||||. || ||.||. .|.|||.|.| ..||||..|.... ..||.|. .|.|. | |||
itpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.
EmGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV----SGGETRSVHQFHYQSWPDMGVPQYP--TTLISYTQTVKHVHERITANT-------KGSTPML
| |.|.|.|...|.| .|...| ..|.| | . ...|.| |...|| .|||.||| .| . ...... ........ . ...|.|
e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl
VHCSAGVGRTGTFISLYCMLAQVieESRVDIFGFIQKMRKDRPN-MVQTADQYILIHTALVEAYM
||||||||||||.. .|.|| .. |..||.. ....|. ||. .||. .||. .. .|.| ..
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
|
|||||||||
| subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 168-424 | 2e-56 | 186.0 | In-house | 25-273 (283) | alignment | ||
Range on Protein: 168-424
Range on HMM: 25-273/283.0
KTVAMKPENKAKNRFKNIVAFDHSRVVLETLKDdphsDYYNANYIR---DDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVY
..|. ||| |||...||. | || |... || || .| ..| .| .|.||.| . |||.....|.....||.|.. |. . .|. |
adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy
WPKEmGkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV-SGGETRSVHQFHYQSWPDMGVPQYPTTLISYtqtvKHVHERITAntKGSTPMLVHCSAGVGR
|||. | |. .| | || . . | ... | .| . . .. | ..| .|. . | | . .|..||||.|.||
WPkr.G.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf....nkvislqte..skkgPivvhCstgiGr
TGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDV
|..||.. . . .. || ||.| .. ||..|. .||| ||| |.|.. .| . |.|..
tavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqi
|
|||||||||
| subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 168-418 | 6.9e-45 | 148.4 | In-house | 33-278 (307) | alignment | ||
Range on Protein: 168-418
Range on HMM: 33-278/307.0
KTVAMKPENKAKNRFKNIVAFDHSRVVLETlkDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPK
|| | |||.... . |..|.|... | ||| |||. | ||.|| | ... .|| .. ||.| ||.|. ...| .| .| |||
vtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpl
EMGKSKTFGG----IEVKLRTIEEFS--DHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKhvheritantKGSTPMLVHCSAGV
| |. ..|| | |. ..... ... | ..| . ....|..... .. ||| |||| | | ..|. |..|||||||
eegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr..........ydtnpvvvhcsaGv
GRTGTFISLYCMLAQVIE-ESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
||.|| ... . ..|. . |. .....|..|. .|| ||. .| |.| ..
GrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
|
|||||||||
| subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 169-419 | 3.8e-80 | 263.7 | In-house | 2-244 (250) | alignment | ||
Range on Protein: 169-419
Range on HMM: 2-244/250.0
TVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDrCTVYWPKE
.|| ||.|| |||. .|.|.|.||||||. | | .||| || .. ...|.|||.|.| .|.|.||||....|.. ..||.||. | .| .. ||| |
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve
mgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERItantkGSTPMLVHCSAGVGRTGTFI
|....|.. |.| |||.| ..|.| . . . . | | |.|. .||| |||.. |. . . . |. .... |..|..|.|||||||.|.||
..kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.....gnaPvivqCsaGvgrsGafi
SLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMS
....| .. .| ||.| .|...|||||..|.. .||. ..... .| |
aidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
|
|||||||||
| 0040439 | (Phosphotyrosine protein) phosphatases II | 169-417 | 5.4e-78 | 257.3 | In-house | 4-246 (249) | alignment | ||
Range on Protein: 169-417
Range on HMM: 4-246/249.0
TVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKe
.||..|||| |||...|...|||||.|. |.. ..|||.||.|| . |..|||.|.| . ...||||..|.... ..||.|. | |. | |||
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.
mGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERItantKGSTPMLVHCSAGVGRTGTFI
|.|...|.. |.|. .|...| ..|.| .. . ||.| |....| .|||.|||... .|... . |....|.. . ..|.|||||||||||||||
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel....pkggpvlVHCsaGvgRtGtfi
SLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAY
.| || |. .| .||.. ....|. ||..||. .||. .. || | .
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
|
|||||||||
| 0042113 | (Phosphotyrosine protein) phosphatases II | 169-415 | 1.5e-75 | 249.1 | In-house | 2-241 (245) | alignment | ||
Range on Protein: 169-415
Range on HMM: 2-241/245.0
TVAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKe
.||..|||| |||...|...||.||.| . |..|||.||.|. .. ...|||.|.| . ...||||..|.... ..||.|. | |. | |||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.
mGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitantKGSTPMLVHCSAGVGRTGTFI
| |.|.|.. |.|...| ..| ..|.| |. . .|.| |...|| .|||.||| .. .|.. . |... .. ....|.|||||||||||||||
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtfi
SLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
.| || |. .| .|... ....|. ||..||| .||. .. || |
aaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
|
|||||||||
| 0037934 | (Phosphotyrosine protein) phosphatases II | 169-415 | 1.3e-70 | 233.0 | In-house | 3-240 (243) | alignment | ||
Range on Protein: 169-415
Range on HMM: 3-240/243.0
TVAMKPENKAKNRFKNIVAFDHSRVVLetlkDDphSDYYNANYIRDDKgkkTFIAAQAPNTASIND----FWRLIWQENVCSVVMVTNILEGGKDRCTVY
..|..|||. |||...|...|||||.| .. |||.|||.|. . ..|| |.| . ...| |||..|.... ..||.|. | |. | |
siallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy
WPkemgKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVS-GGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITA--NTKGSTPMLVHCSAGV
|| ..|.|...|.| .|...| ..|.| .. .. ...|| |...|| .|||.|||. |. |... . |. . |... . ... |.||||||||
wp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv
GRTGTFISLYCMLAQVieesRVDIFGFIQKMRKDRPN-MVQTADQYILIHTALVE
|||||.| .| || .. .||.. ....|. ||. .||| .||. .. || |
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
|
|||||||||
| subfamily_PTPN13_pd | Subfamily PTPN13 | 169-416 | 4.8e-60 | 198.1 | In-house | 29-268 (273) | alignment | ||
Range on Protein: 169-416
Range on HMM: 29-268/273.0
T-VAMKPENKAKNRFKNIVAFDHSRVVLETLKDdphsdYYNANYIRDDKGKKTF--IAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYW
. |. | |||.|||..|.. .|..|| |. | ||..|. ||... ||.| | ...|||...|. .. ..|||. |.|| .| ||
cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw
PKEMGKSKTFGG-IEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHEritantkGSTPMLVHCSAGVGRT
|....|. . . .||.| ... .. | | | ||.. ||.| | .... .||| |||. .. |. . . |..... ..|..||||||.||.
PesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.......dagPivvhcsaGiGrs
GTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
||.|... .| . . .|. ..|.|. | .||| ||||... |..|.
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
|
|||||||||
| subfamily_eak_pd | Subfamily eak | 169-416 | 2.3e-13 | 44.2 | In-house | 45-304 (332) | alignment | ||
Range on Protein: 169-416
Range on HMM: 45-304/332.0
TVAMKPENKAKNrFKNIVAFDHSRVVLETLKDDPhSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKE
... . |. .| .|| .|. | | . . .. | || . . . .| . ... . ||... ... ..|.. . .| . .. |.|..
setarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk
MGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQvsGGETRSVHQFHYQSWPDMGVPQYPTtLISYTQTVKHVHERITANTKG---------------STPM
. || ..|. . . . | | ... | || |. ... | .. .|.| .... ...|.| ...| |
treelkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpkyed.flalrkvmkevGvlllivmksallsstlkkyihtppsfap
LVHCSAGVGRTGTFISLyCMLAQVIEESRVDIF---GFIQKMRKDRPNMVQTADQYILIHTALVEA
.. .. | |.|.|. . .| ..|.. . . . .| |... | | .| |. .|. ....
iiqsarGsaraGvfvvi.dllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
|
|||||||||
| subfamily_CG7180_pd | Subfamily CG7180 | 170-421 | 5.1e-53 | 174.6 | In-house | 36-294 (296) | alignment | ||
Range on Protein: 170-421
Range on HMM: 36-294/296.0
VAMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKdRCTVYWPKEM
... ||. ||| ..| .|. |||||.|. . .||| || |. || .| .|| . ....||||...|.. .||..|. . | . |||...
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks
gkSKTFGGIEVKLRTIEEFSDHVHRVLDVKQV----------SGGETRSVHQFHYQSWPD-MGVPQYPTTLISYTQTVKHVHERItANTKGSTPMLVHCS
. .| |.|.. . ..... . | . ... ||| |..|... |. || ..|| . |. . |.. . . |..|..|
..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv.dedpeegPvvvvss
AGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGN
|..|.| .... | .|..| .||.|......|..||..|.. ..| | | ||.. .
dGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
|
|||||||||
| subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 170-414 | 7.6e-46 | 151.3 | In-house | 27-292 (297) | alignment | ||
Range on Protein: 170-414
Range on HMM: 27-292/297.0
VAMKPENKAKNRFKNIVAFDHSRVVLetLKDDPHSDYYNANYIR--DDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPK
.| .. |||...|.|.| .|| | |. . .|| ||.|. |.. . .| || | |...|||.|.....| .|||... |.|.|.|. |||.
sakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps
EMGKSKTFGGIEVKlrTIEEFSDHVHRV--LDVKQVSGGETRSVHQFHYQSWPDMGVP-------QY-----------P--TTLIS-YTQTVKHVHERIT
.. .. | . |. . ..||. .|| ... . |.| |. . |||| ||| .. | .|. .| | | .
vvqerlkagdvvve..flsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslr
ANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
|. ....||||||||||.| . .||.. . |. .....|. |. .||| .|. |...| .
aemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
|
|||||||||
| 0049772 | (Phosphotyrosine protein) phosphatases II | 170-415 | 7.6e-37 | 123.1 | In-house | 40-278 (314) | alignment | ||
Range on Protein: 170-415
Range on HMM: 40-278/314.0
VAMKPENKAKNRFKNIVAFDhSRVVLETLKDDPhSDYYNANYIRDDkgkKTFIAAQAPNTASINDF----------WRLI--WQENVCSVVM--------
|| ...|. |||...|. .| .||.| .| . |||.||.|.. ..|||.|.|. ..|| ||.. .. || .||
vadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad
-------------VTNILEGGkdrcTVYWPKEMGKSKtfggievklrtiEEFSDHVHRvldvkqvsggeTRSVHQFHYQSWPDMGVPqyptTLISYTQTV
... ..| ...... | || |. . .| . .... .|| ..| .| . . .
elsrLdaAlgKtpllildgng....neptaadlellk............eelydpelf...........erlgikylripvpDgsap....lledfdefl
KHVHERitantKGSTPMLVHCSAGVGRTGTF-ISLYCMLAQvieesRVDIFGFIQKMRKDRP-----NMVQTADQYILIHTALVE
....| . .| ||||.||.|||||| . |.|... .|.. .. .|. || ..... .||. |. || |
efieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealle
|
|||||||||
| subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 171-416 | 4.3e-75 | 246.9 | In-house | 2-239 (239) | alignment | ||
Range on Protein: 171-416
Range on HMM: 2-239/239.0
AMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKG-KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEM
| | ||||||. |||..|||||||| | .|||||| ||.|.|| | |..||.| ..| ||||..||| | .||.| ..|| | .| |||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst
GKsktFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQtvkhvheRITA-NTKGSTPMLVHCSAGVGRTGTFI
| . . | || | |.|.. | . . || | | |.|.|. ||| ||||| |... . .|| . |. | ..||||||||||.|.
sk...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.......kitkdslpgarpwvihcsagvgrtgafl
SLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEA
. .|| | .. |||| ... .|.||| ||||..||..|| |..||
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
|
|||||||||
| subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 171-415 | 1.3e-74 | 245.4 | In-house | 3-239 (239) | alignment | ||
Range on Protein: 171-415
Range on HMM: 3-239/239.0
AMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKG-KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEM
| | ||||||. |||..|||||||| | .|||||| ||.|.|| | |..||.| ..| ||||..||| | .||.| ..|| | .| |||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst
GKsktFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQtvkhvheRITA-NTKGSTPMLVHCSAGVGRTGTFI
| . . | || | |.|.. | . . || | | |.|.|. ||| ||||| |... . .|| . |. | ..||||||||||.|.
sk...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr.......kitkdslpgarpwvihcsagvgrtgafl
SLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
. .|| | .. |||| ... .|.||| ||||..||..|| |..|
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
|
|||||||||
| subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 171-415 | 2.9e-68 | 224.8 | In-house | 15-262 (270) | alignment | ||
Range on Protein: 171-415
Range on HMM: 15-262/270.0
AMKPENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNANYIR-DDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEM
.|. ||...|. ..||.||.|..|... |.||||.| |. ||..|||..| .....|||.||.|.| ..||.|.. | |...| .|||.|
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep
GKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHER--ITANTKGSTPMLVHCSAGVGRTGTF
... .. ..| ....| .. ... .. . ||.| . |.|..||| |||. . . .| .| .| ... . ... ..|.|||||||||||||.
kekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl
ISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
| | .. . |...||. |...||||...||. .|| ... |.||
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
|
|||||||||
| subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 172-418 | 5.4e-53 | 174.6 | In-house | 34-278 (287) | alignment | ||
Range on Protein: 172-418
Range on HMM: 34-278/287.0
MKPENKAKNRFKNIVAFDHSRVVLETlKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEmGK
. . |||. ... .|..||.| . . . ||| ||||. . ...|||||.| .|...||||........||...| .| .. .| |||. .
eelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.ev
SKTFGGIEVKLRTIEE-FSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHvHERITANTKGSTPMLVHCSAGVGRTGTFISL
|| | | . .. | | . .. . |.| |.|... |||| ... || .. ||. | .. .... |..||...|.||.|.....
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkq.hielardasevGPlvvhddvGiGrsGillat
YCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
. .. . . |||. . ..|. | .||.. |. |. ||| |
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
|
|||||||||
| subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 173-415 | 9.2e-45 | 147.5 | In-house | 53-281 (290) | alignment | ||
Range on Protein: 173-415
Range on HMM: 53-281/290.0
KPENKAKNRFKNIVAFDHSRVVLetlKDDPHSDYYNANYIRDDkgKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKS
| . |||.|..| | .||.| || . || |||.. | .|| .| . .... |.||.. ||.| .||. ...| || .| |.|.. |.
kntefkknrykdvvcndktrvil...kdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev
KTFGGIEVKLRTIEEFSDH-VHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKhvheritantKGSTPMLVHCSAGVGRTGTFISLY
||| | | .. .. ....| |... | .. .. .|||| |.. .|. .... | | |. ||||||.||||||...
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr..........kasGpvvvhcsaGiGrtGtfvaie
CMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
| ... .|. . .. .|. | | || ||... .|..
vglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
|
|||||||||
| subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 174-415 | 4.5e-66 | 217.5 | In-house | 1-237 (237) | alignment | ||
Range on Protein: 174-415
Range on HMM: 1-237/237.0
PENKAKNRFKNIVAFDHSRVVLETLKDDphSDYYNANYIRDDKG-KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKeMGKS
.|||.|||. ||||.|||||||. . ||| ||.|... | |..|||| | .| .|||...|||. .||.| ..|| . .| |||. .
senkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqp
KTFGGIEVKLRTIEEFSDHVHRVLD-VKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVkhvHERItANTKGSTPMLVHCSAGVGRTGTFISLY
...| . | |. |||||. | | .|... | | .||... |||| ||||. ..|. . . . .| |.| ..|||||||||| |. .
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkni...inrs.phvsesgpwiihcsagvgrtgiflvid
CMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
.|| | |. |||. ... . .||| ..|| |||..|| ...|
amlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
|
|||||||||
| subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 175-415 | 2.4e-38 | 126.8 | In-house | 42-269 (288) | alignment | ||
Range on Protein: 175-415
Range on HMM: 42-269/288.0
ENKAKNRFKNIVAFDHSRVVLEtlkDDPHSdYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKT
.| ...|..|. | .|| |. |||. | .|| . | |. .| |||| . |. .|... ...| .||....|| ||.. .|.| ..|..
anptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar
FGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRS-VHQFHYQSWPDMGVPQyptTLISYTqtvkHVHERItanTKGSTPMLVHCSAGVGRTGTFISLYCM
.| . . . |.. .| .. ||.. | . |.. |.| |||. .|. .. |.. . |..||.|||||||||.| .
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPe...nylspl....rllevl...kslqkPivvhssaGvGrtgtlililia
LAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVE
| .. . . | ...|.|..| . .|| ||. .| . |
leslrlddflgirsllaklreerfkaiqtemqylyvhrcvle
|
|||||||||
| subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 175-419 | 3.1e-35 | 116.5 | In-house | 34-272 (285) | alignment | ||
Range on Protein: 175-419
Range on HMM: 34-272/285.0
ENKAKNRFKNIVAFDHSRVVLETlkddPHSDYYNANYIRD-DKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSK
| ||. .. . . .||||. || |...| | . |.|..| | ...|||..|.||... |.|. ..||| ..|..|.|...|.
anpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv
TFGGIEVKLRTIEE--FSDHVHRVLDVKQVSGGETRSVHQFHYQ--SWPDMGVPQYPTTLISYTQTVKHVheritaNTKgSTPMLVHCSAGVGRTGTFIS
|| |. | .| . . | | . . .. | | ||| |. .| . ||.| | | .|. |||||||||| ||.
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv......npk.ekpicvhcsagvgrtatfvg
LYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMS
. ...|. .... ...|| | . ||. |..... |.| ..
idyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig
|
|||||||||
| subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 175-414 | 5.4e-27 | 89.0 | In-house | 50-282 (302) | alignment | ||
Range on Protein: 175-414
Range on HMM: 50-282/302.0
ENKAKNRFKNIVAFDHSRVVLETLKDdphsDYYNANYIRDDKGKKTFIAAQAPNTASI---NDFWRLIWQENVCSVVMVTNILEGGKdRCTVYWPKEMGK
.| .||. ... . |. .| ||. .| .|.|| . . ... | || |.. | ..|||...||.. |||.. | | ..||..|.
knlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd
SKTFGGIEVKLRTIEEFSDHVhRVLDVKQVSGGETRSV--HQFHYQSWPDMGVPQypttliSYTQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFIS
|..| . | | .|. .... . . . | . || . . |.. ||. .|....| ... . ..|.. .... |.|| |.|..
ykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpv......kyaeliktaakvfakkikadentvivSknGaGRagaflt
LYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
| . .. ... . | ....|..||..|....||. .. ||.
lavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
|
|||||||||
| subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 175-418 | 7.1e-20 | 65.8 | In-house | 46-280 (303) | alignment | ||
Range on Protein: 175-418
Range on HMM: 46-280/303.0
ENKAKNRFKNIVAFDHSRVVLEtlkDdphSDYYNANYIRDDKGKKTfIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKsKT
.| |||| ... .|||.| | | | | |.|. | ||. | .| | . . |||..| ...| |... | | . .|..
knmdknrfvdvicldhskvkls...d...ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf.lk
FGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRS-VHQFHYQSWPDMGVPQYPTTliSYTQTVKHVHERITANTKgSTPMLVHCSAGVGRTGTFISLYC-
| ... . . || | || |. .| .| ||..|| .| . . . . . . .. ||| . .|.||.||| .
feersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysd.stptvymslsgcgragtfalfeta
MLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
|. |.. .|. ....|. | || |. ...| | | .
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
|
|||||||||
| subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 175-300 | 1.3e-19 | 65.1 | In-house | 46-184 (350) | alignment | ||
Range on Protein: 175-300
Range on HMM: 46-184/350.0
ENKAKNRFKNIVAFDHSRVVLE-TLKD-------DPHSDYYNANYIRDD----KGKKTF--IAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDR
| ||||.|||. ..|||| |. .|| .|| ||||.. . . | ||.||| ..||...| . .| ....|. | . ..
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek
CTVYWPKEMGKSKTFgGIEVKLRTIEEFSDHVHRVLDVKQ
| ||.. . .| .. | . | . | . .. |||.
cyrYWqegsydditv.klaskwenimgindsslysadvkk
|
|||||||||
| subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 175-292 | 1.5e-13 | 44.8 | In-house | 47-175 (349) | alignment | ||
Range on Protein: 175-292
Range on HMM: 47-175/349.0
ENKAKNRFKNIVAFDHSRVVLETLKDDP--------------HSDYYNANYIRDDK--GKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGK
| ||||.|.|. ..||||.|. . || ||||.. . .| .|| ||| ....||...| ..| |. ... | .
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl
DRCTVYWpkemgKSKTFGGIEVKLRTIEEFSDHV
..| .|| . .. .|.|||. ... |
ekcdiyw.....qelsysnitvklqnsslyianv
|
|||||||||
| subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 175-258 | 2.2e-10 | 34.6 | In-house | 36-121 (347) | alignment | ||
Range on Protein: 175-258
Range on HMM: 36-121/347.0
ENKAKNRFKNIVAFDHSRVVLET-----LKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMvtnILEGGK
. .||| |. | .|||| . |. | || .|. |. .| .| .| | .. |||... .| || |.| |
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt...ifepik
|
|||||||||
| subfamily_Cele-PTP-3_pd | Subfamily Cele-PTP-3 | 175-276 | 1.3e-06 | 20.2 | In-house | 28-117 (275) | alignment | ||
Range on Protein: 175-276
Range on HMM: 28-117/275.0
ENKAKNRFKNIVAFDhsrvvlETLKDDPHSDYYNANYIRDDKGKktFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGkdrcTVYWPKEMGKSKT
| |||| |...|| | | . . . .|| .| |. |. .|||| .. |. .|.| || .|| . | | . ||| .
rngeknrftnvtcfd......eildrenqeffvhantfrtpygn..flisqapndstnadhlhllwiynvqtvvclvlpeeag....gyfvpkegetfts
FG
|
fq
|
|||||||||
| subfamily_Sponge-PTP2_pd | Subfamily Sponge-PTP2 | 175-267 | 5.7e-06 | 19.3 | In-house | 25-85 (169) | alignment | ||
Range on Protein: 175-267
Range on HMM: 25-85/169.0
ENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNAnyirddkgkktfiaaqapntasindfwRLIWQENVcSVVMVTnileGGKDRCTVYWPK
|..||| .| | || |. . .| ||| || |.||. | ||..| |. | .||.
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetna.svivvl....Gdtddknnfwpe
|
|||||||||
| subfamily_Sponge-PTP-2_pd | Subfamily Sponge-PTP-2 | 175-267 | 7e-06 | 19.1 | In-house | 26-86 (169) | alignment | ||
Range on Protein: 175-267
Range on HMM: 26-86/169.0
ENKAKNRFKNIVAFDHSRVVLETLKDDPHSDYYNAnyirddkgkktfiaaqapntasindfwRLIWQENVcSVVMVTnileGGKDRCTVYWPK
|..||| .| | || |. . .| ||| || |.||. | ||..| |. | .||.
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetna.svivvl....gdtddknnfwpe
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 176-414 | 1.8e-77 | 255.3 | Pfam-A | 1-234 (235) | alignment | ||
Range on Protein: 176-414
Range on HMM: 1-234/235.0
NKAKNRFKNIVAFDHSRVVLetlKDDPH-SDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKT
|| |||.|.|...|..|| | |.... |||.||||.. | ||.|||.|.| .|.||||..|||.| ..||.|. | |. | |||.|...|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt
FGGIEVKLR-TIE-EFSDHVHRVLDVKQVSGG-ETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHeritanTKGSTPMLVHCSAGVGRTGTFISLY
.| |.|.|. .. . .. . |.|..|. . |.|.|.|.||..||| |||. |. |... . |.. . .. |.|..|||||||||||||..|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvald
CMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
..| |. .|. ||.. .....|| ||.|||...||| .. |..
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 176-414 | 1.8e-77 | 255.3 | In-house | 1-234 (235) | alignment | ||
Range on Protein: 176-414
Range on HMM: 1-234/235.0
NKAKNRFKNIVAFDHSRVVLetlKDDPH-SDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKT
|| |||.|.|...|..|| | |.... |||.||||.. | ||.|||.|.| .|.||||..|||.| ..||.|. | |. | |||.|...|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt
FGGIEVKLR-TIE-EFSDHVHRVLDVKQVSGG-ETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHeritanTKGSTPMLVHCSAGVGRTGTFISLY
.| |.|.|. .. . .. . |.|..|. . |.|.|.|.||..||| |||. |. |... . |.. . .. |.|..|||||||||||||..|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvald
CMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
..| |. .|. ||.. .....|| ||.|||...||| .. |..
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
| 0041856 | (Phosphotyrosine protein) phosphatases II | 176-425 | 6.4e-47 | 154.8 | In-house | 1-179 (182) | alignment | ||
Range on Protein: 176-425
Range on HMM: 1-179/182.0
NKAKNRFKNIVAFDHSRvvletlkddpHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTnileggkdrCTVYWPkemgksktf
|. |||...|. .|||| ..|| |||... . ..|||.|.| ...||.|....... ..|..| . |||
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........
ggievklrtieE-FsdhvhrvldvkqvsggeTRSVHQFHYQSWPDMGVPQyPTTLISYTQTVKHvheritantkGSTPMLVHCSAGVGRTGTFISLYCML
| . .| ..|..| .|||.||| . .|... ..|.. . | |||||||||||||.. .| |.
...........ell.................erlgiqylylpwpDhgvpd.ldelldfieevle..........eggpvlVHCsaGvgRtgtlvaaylmk
AQvieesRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSGNTDVP
. .|... .. .|. ||.||.| .||.... || | .. ..|...
kl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
|
|||||||||
| subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 176-418 | 2.2e-35 | 116.8 | In-house | 55-290 (305) | alignment | ||
Range on Protein: 176-418
Range on HMM: 55-290/305.0
NKAKNRFKNIVAFDHSRVVLEtlkDDPHSDYYNANYIRDD-KGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKT
...|||.... . |.| | |. . . ||| |||. .| ||.|| | .|..|| .. |..| .||. . .| || .|. ||| .|. ..
aitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle
F-GGIEVKL----RTIEEFSDHVHRVLDVkQVSGGETRSVHQFHYQSWPDMGVPqyPTTLISYtqtvkhvhERITANTKGSTPMLVHCSAGVGRTGTFIS
. .|| |. . .| .. .|.. ||... || .... ||| ||| | | | | ..| |..||||||.||||| ..
lksgivvenvsgskpmerdaeiqitllnl.tysgdqkmsvrhlqwtewpdrgvp..pckltsl........ellsairgskvpivvhcsagigrtgtiva
LYCMLAQVIEESRVD-IFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
. .| .. |. .. . ... .| .| .|. ||. || ... ..
ieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
|
|||||||||
| subfamily_Cele-PTP-12_pd | Subfamily Cele-PTP-12 | 176-275 | 3.5e-09 | 30.6 | In-house | 34-131 (332) | alignment | ||
Range on Protein: 176-275
Range on HMM: 34-131/332.0
NKAKNRFKNIVAFDHSRVVLEtlKDDPHSDYYNANYIRDDKGKKTFIAAQAPNTA-SINDFWRLIWQEnVCSVVMVTNILEGGKDRCTVYWPKEMGKSKT
| || . .|||||| | .| . |.|||... | ..| |||| . |||.. . |...| .. . | . | . | |.
nmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvser.kpsmilvfgdidekqkrkapydisdrgfeks
F
|
f
|
|||||||||
| subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 177-418 | 2.2e-24 | 80.7 | In-house | 44-277 (312) | alignment | ||
Range on Protein: 177-418
Range on HMM: 44-277/312.0
KAKNRFKNIVAFDHSRVVLETlkdDpHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKS----
| ||. || .| | | | | ||... . |...|.| .. ||.| .|..... ..| | ..|. | .|
kdlnrypniqcwdrgrftlag...d.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled
-KTFGGIEVKLRTIEEFSD-HVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTlisytqtvkhVHERITANTKGSTPMLVHCSAGVGRTGTFISL
. . .. | |||| | . |. . .. . |||| |.|. | . ..| | |.. |||||||||||.. .
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdt..........alrllsavkkdkkpviahcsagvgrtgtlali
YCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
|.| . . .. .|||| |.. ||. ...| .
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
|
|||||||||
| subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 179-414 | 9.5e-26 | 85.6 | In-house | 22-256 (290) | alignment | ||
Range on Protein: 179-414
Range on HMM: 22-256/290.0
KNRFKnIVAFDHSRVVLETLKDDPHSDYYNANYIRDDKGKkTFIAAQAPNTAS-------INDFWRLIWQENVCSVVMVTNILEGGKD----RCTVYWPK
..| . . . ..||||. . .|| ||.. .| .|. |.| .. |..|| .. ||.| .|||. . | .. |. | |.
dqRle.vpLveatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe
EMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQvSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVheritantkgSTPMLVHCSAGVGRTGTF
..|.. .|.|..|| |. | .| | || ..| | ...| .. |.. . ||.| |.|| ||..||| |. | ..
svgeelkfkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas..........ktpvivHcvdGiSrsAal
ISLYCMLAQVI-EESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
.. .. .. | . ....|| | .....| .. . ..|
aaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
|
|||||||||
| 0044763 | (Phosphotyrosine protein) phosphatases II | 188-414 | 4.2e-36 | 119.6 | In-house | 2-168 (178) | alignment | ||
Range on Protein: 188-414
Range on HMM: 2-168/178.0
FDHSRVVLETLKDDPHSDYYNANYIRDDkgkktFIAAQAPNtasiNDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGksktfggievklrtiee
.|..||.|..| . . |||.||..| .. ......|. |...|...... ..|..|. ||.|. | |||.|.|
ldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................
fsdhvhrvldvkqvsggetrsvHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHeritanTKGSTPMLVHCSAGVGRTGTFISLYCMLAQvieesRVDIFG
|... .||.|||. . . .. ..... . | ||||||||||.||.. .| |. . .....
......................iqylhipipDhgvpdllehflefvefieeal......dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glslee
FIQKMRKDRPnMVQTADQYILIHTALV
|. .|. || .|.. .|. ..
aielvrerRp.ivpnpgqlrqLyefel
|
|||||||||
| 0046846 | (Phosphotyrosine protein) phosphatases II | 197-413 | 1.7e-36 | 121.0 | In-house | 5-169 (176) | alignment | ||
Range on Protein: 197-413
Range on HMM: 5-169/176.0
TLKDDPHSDYYNANYIRDDKgkktFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKtfggievklrtieefsdhvhrvl
| .|...|| |||.| .. .|| |.| .. ||......... ||..|. | |. .|. ||| ... .
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................
dvkqvsggetrsvhQFHYQSWPDMGVPQYpttlISYTQTVKHVHERITANtkgsTPMLVHCSAGVGRTGTFISLYCMLAqvieESRVDIFGFIQKMRKDR
|... |||.|||.. . .. ..|..... | |||||||.|||||.. .| . | .... ....|. |
..............qylhlpwpDhgvpdl....elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqR
P-NMVQTADQYILIHTAL
| ..||| .|| .. ..
plgavqtpeQyrflyefe
|
|||||||||
| 0043147 | (Phosphotyrosine protein) phosphatases II | 201-410 | 5.3e-39 | 129.0 | In-house | 2-154 (172) | alignment | ||
Range on Protein: 201-410
Range on HMM: 2-154/172.0
DPHSDYYNANYIRDDKGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNIleggkdrctvywpkemgksktfggievklrtieefsdhvhrvldvKQ
|..|||.||.|. . ||| |.| ..||||....... .|..|.
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................ly
VSGGETRSVHQFHYQSWPDMGVPqYPTTLISYTQTVKHVHeritaNTKGSTPMLVHCSAGVGRTGTFISLYCMLaqvieeSRVDIFGFIQKMRKDRPNMV
...|.. |..| .|||.||| . |.. . ..... . . . |.|||||||||||||.. .| || ..... .. .|. ||..|
dpellerlgiqylylpwpDhgvp.llellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgav
QTADQYILIH
|. .||....
qnpsqyrfly
|
|||||||||
| 0051429 | (Phosphotyrosine protein) phosphatases II | 202-437 | 8.2e-49 | 162.0 | In-house | 2-244 (272) | alignment | ||
Range on Protein: 202-437
Range on HMM: 2-244/272.0
PHSDYYNANYIRDDKG---KKTFIAAQAPNTASINDFWRLiWQENVCSVVMVTNILEGGKDRCTVYWP----------KEMGKSKTFGGIEVKLRTIEEF
| |.|.||... . .........| .....||||| ..... ..|.... | |.. | ||| .. . ..| . |.| .| .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell
SDHVHRVLDVKQV-SGGETRSVHQFHYQSWPDMGVPQYPttlisYTQTVKHVHEritantkgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVD---
.|...|.| .. . | ||.| |...||..|||.|||| . . . ...... . |.|||||||..||||.. |. .|..| .| ||
ldyilrellltlllsagearevmhlhytdwpdhgvpqea.....llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYl
-----IFGFIQKMRKDRPNMVQTADQYILIHTALVEAyMSGNTDVPVSSFEAKLSSLQ
........|. ||..||| .||. .. ||.|. . . ..|... ..| | ..
ltnlyleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid
|
|||||||||
| 0051082 | (Phosphotyrosine protein) phosphatases II | 202-413 | 4.3e-34 | 112.6 | In-house | 1-149 (151) | alignment | ||
Range on Protein: 202-413
Range on HMM: 1-149/151.0
PHSDYYNANYIRDDkgkktFIAAQAPnTAsinDFWRLIWQENVCSVVMVTNILEGGkdRCTVYWPKEMgksktfggievklrtieefsdhvhrvldvkqv
|.|||.|..|. . ... ..| .| ||..|...... ..|.... | | |. |.|..
plsdyinfsyvtgg.....lyrsggp.la...dflellkelgiktivnlrseeerg..ycpeylpelg................................
sggetRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHvheritantKGSTPMLVHCSAGVGRTGTFISLYCMLAQvieesrVDIFGFIQKMRKDRPNMVQ
. |..... .||| |.|... ..... . . . |.. |.|||||||.|||||.. ||.|| . |... .. .|. ||..||
.....ievlhipildwpdpglplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvq
TADQYILIHTAL
. .|..... ||
pnqqflfqlfal
|
|||||||||
| 0036282 | (Phosphotyrosine protein) phosphatases II | 204-410 | 1.2e-42 | 140.9 | In-house | 2-163 (174) | alignment | ||
Range on Protein: 204-410
Range on HMM: 2-163/174.0
SDYYNANYIRDDKGKKTFIAAQAPNTasindFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKemgksktfggievklrtieefsdhvhrvldvkqVSG
|||.||... . .|| |.| . ||........ .|||... | |. .| ||| .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre
GETRSVHQFHYQSWPDMGVPQYPTtLISYTQTVKHVHERitantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIeESRVDIFGFIQKMRKDRPNMVQTA
..|...|..| |||.||| .. |.. . |...... ... |.|||||||||||||.. .| || . . || ||.. .....|. ||.||||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp
DQYILIH
.||. ..
sQyrfly
|
|||||||||
| subfamily_Cele-PTP-9_pd | Subfamily Cele-PTP-9 | 214-406 | 7e-18 | 59.6 | In-house | 39-210 (255) | alignment | ||
Range on Protein: 214-406
Range on HMM: 39-210/255.0
DdkgkktfiaaqapntaSINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVklRTIEEFSDHVHRVLDVKQVSG--GETRSVHQ
... |.. | | . |||... | |...| |.| | . . . ..| | . .| | | |.. | .|. |.
l................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnv..tttkssadvvlrtleitstlgekkkthtvkh
FHYQSWPDMGVPQYPTTLISYTQTVkhvheritANtkgSTPMLVHCSAGVGRTGTFI---SLYC-MLAQVI--EESRVDIFGFIQKMRKDRPNMVQTADQ
..|. |.. |. . . . | . | ...||||.|.||. .|. ..| |. .. | .| .....|. |. ..| |
ysykGWieknaPelareilnilkvv........rd...sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlq
Y
l
|
|||||||||
| subfamily_Anemone-PTP-3_pd | Subfamily Anemone-PTP-3 | 216-410 | 4.4e-20 | 66.7 | In-house | 2-197 (199) | alignment | ||
Range on Protein: 216-410
Range on HMM: 2-197/199.0
KGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRV--LDVKQVSGGETRSVHQFH
||.. .||.| | .. |||...|. .||| . . .||| . .| . | .|| .|.. . | . . || . ..
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq
YQSWPDMGVPQYpTTLISYTQTVKHVHERITANtkGSTPMLVHCSAGVGRTGTFISLYCMLAQvIEE---SRVDIFGFIQKMRKDRPNMVQTADQYILIH
. || . |. . .. . . . | . . .|..|||| | | || |..| . || | ||.| ...|. | .. . ..| .|.
ftswkekttpnv.alfvgfvvasrevskkyeqe..kdapvivhcsdgqgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfiy
|
|||||||||
| subfamily_Nvec-PTP-3_pd | Subfamily Nvec-PTP-3 | 216-410 | 7e-20 | 66.0 | In-house | 1-196 (198) | alignment | ||
Range on Protein: 216-410
Range on HMM: 1-196/198.0
KGKKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRV--LDVKQVSGGETRSVHQFH
||.. .||.| | .. |||...|. .||| . . .||| . .| . | .|| .|.. . | . . || . ..
kgqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq
YQSWPDMGVPQYpTTLISYTQTVKHVHERITANtkGSTPMLVHCSAGVGRTGTFISLYCMLAQvIEE---SRVDIFGFIQKMRKDRPNMVQTADQYILIH
. || . |. . .. . . . | . . .|..|||| | | || |..| . || | ||.| ...|. | .. . ..| .|.
ftswkekttpnv.alfvgfvvasrevskkyeqe..kdapvivhcsdgqgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfiy
|
|||||||||
| 0049260 | (Phosphotyrosine protein) phosphatases II | 218-410 | 6.2e-36 | 118.7 | In-house | 8-143 (152) | alignment | ||
Range on Protein: 218-410
Range on HMM: 8-143/152.0
KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWpkemgksktfggievklrtieefsdhvhrvldvkqvsggetrsvhQFHYQSW
.. |||.|.| ...||||.... .. .||.|. || ||. | |. |... |
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpw
PDMGVPQYPTTLISYTQTVKHVheritaNTKGSTPMLVHCSAGVGRTGTFISLYCMLaqvieeSRVDIFGFIQKMRKDRPNMVQTADQYILIH
||.|||. . |. . ... . . . | |||||||||||||.. .| || .|... ... .|. ||..|.. .|.....
pDhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
|
|||||||||
| subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 218-299 | 1.2e-09 | 32.0 | In-house | 235-312 (440) | alignment | ||
Range on Protein: 218-299
Range on HMM: 235-312/440.0
KKTFIAAQAPNTASINDFWRLIWQENVCSVVMVTNIlEggKDRCTVYWPKEmGKSKTFGGIEVKLRTIEEFSDHVHRVLDVK
|..|||.| | ... |||||. . .. ...|. .. . |..||| . .| ||| . | . |.. | |..|
knafiatqmpldstvldfwrlvhdyristiimlnql.n..dktcsiywpvn.trsvtfgpftvghkgsenmnrvkvrtlelk
|
|||||||||
| subfamily_Cele-PTP-7_pd | Subfamily Cele-PTP-7 | 224-422 | 5.9e-20 | 65.9 | In-house | 96-293 (302) | alignment | ||
Range on Protein: 224-422
Range on HMM: 96-293/302.0
AQAPNTASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTI----EEFSDHVHRVL-----DVKQVSGGETRSVHQFHY
| ... .| || | ||. || .... |... .|. |. ...|. .|| || . |||.| . .| ... ..|. ...
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf
QSWPDMGVPQYPTTLIsytQTVKHVhERItantKgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
.||| | |. . | . . .|. | | . .|||||||||||||.... . .. |. .. .|. | ||...| | . .
sawpdhGapkeaytal...dilkfc.esy....k..knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvt
EAYMSGNT
. | .
kglmekag
|
|||||||||
| subfamily_Cele-PTP-5_pd | Subfamily Cele-PTP-5 | 224-419 | 2.4e-09 | 30.3 | In-house | 120-310 (346) | alignment | ||
Range on Protein: 224-419
Range on HMM: 120-310/346.0
A---QAPNTASINDFWRLIWQENVCSVVMVTNiLEGGKDRCTVYWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDM
| | | . ..||| .|.||.. | .. . |. | . | | . | . .. | . | ..| .. .. |. | .
aqlpqmenesfvedfwymiyqeqihlvylmvp.ddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhl
gvPQYPTTLisytQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHtALVEAYMS
| | || .| .|. . . .. . | | ||. .|| . |. . .|. .......|| |.. || |. |.| |..
..qqppktl....piikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiy.aivfdyia
|
|||||||||
| subfamily_hpo-7_pd | Subfamily hpo-7 | 229-413 | 2.4e-14 | 47.9 | In-house | 44-223 (263) | alignment | ||
Range on Protein: 229-413
Range on HMM: 44-223/263.0
TASINDFWRLIWQENVCSVVMVTNILEGGKDRCTVYWPKEMGKSKTFGGIEVklRTIEEFSDHVHRVLDVKQVSG--GETRSVHQFHYQSWPDMGVPQYP
|. |.. | | . |||... | |...| |.| | . . . ..| | . || . . |.. .. | .|. |... |. |.. |. .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnv..cttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela
TTLIsytQTVKhvherItanTKGSTPMLVHCSAGVGRTGTFI---SLYC-MLAQVIE--ESRVDIFGFIQKMRKDRPNMVQTADQYILIHTAL
. . .| . ...| .. ||||.|.||. | ..| |. .. . .| .....|. |. ..| | .
reil...nilk.....v...arnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
|
|||||||||
| 0048076 | (Phosphotyrosine protein) phosphatases II | 264-413 | 7.1e-27 | 89.2 | In-house | 2-139 (145) | alignment | ||
Range on Protein: 264-413
Range on HMM: 2-139/145.0
YWPKEMGKSKTFGGIEVKLRTIEEFSDHVHRVLDVKQVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitantkgSTPMLVHCSAGVGR
||| | . .|.. . |. . . .. .||.. ...| . |..| .|||.|||. . .|.. . ....... |.||||||||||
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.......ggpvlVHCsaGvgR
TGTFISLYCMLAqvieeSRVDIFGFIQKMRKDRPNMVQTADQYILIHTAL
|||.. .|.|| .|... ....|. ||..|.. .|.. .. ..
tgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
|
|||||||||
| PTEN_1 | 289-400 | 1e-06 | 23.7 | In-house | 65-179 (196) | alignment | |||
Range on Protein: 289-400
Range on HMM: 65-179/196.0
SDHVHRVLDVKQVSGG-------ETRSVHQ--FHYQSWPDMGVPqyptTLISYTQTVKHVHERITANTKgSTPMLVHCSAGVGRTGTFISLYCMLAQVie
.|... |... . |.. .. .. ...| |.| .| . .| ..| . .. . |||| ||.||.|| . | | ..
edgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgap....slselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaayLmykgk..
ESRVDIFGFIQKMR-KDRPNMV
. . . .....| . .||.
ltadeAlelvrekRppgapnsp
|
|||||||||
| subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 300-453 | 4.9e-33 | 109.1 | In-house | 82-230 (440) | alignment | ||
Range on Protein: 300-453
Range on HMM: 82-230/440.0
QVSGGETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERitantKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNM
..| |.|...|.|||.||| |||.. .. | |.. .|. |. |.|||||||.|||| |.. ..| .. ..||| ||. ||..||.|
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek.....agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqm
VQTADQYILIHTALVEAYMSGNTDVPVSSFEAKLSSLQERNPLTQKLNIEQEFE
||| .|| ..| |..|. ..|.| . .. .| || |.| ..||||
vqtpeqyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
|
|||||||||
| subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 304-414 | 2.2e-19 | 64.4 | In-house | 212-341 (350) | alignment | ||
Range on Protein: 304-414
Range on HMM: 212-341/350.0
GETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHV----HERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLA------QVIEES---------RVD
. |.|.... |.|... | ... . ... . ... |.|.|||||||||||||...| .| .. .|| |
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl
IFGFIQKMRKDRPNMVQTADQYILIHTALV
|. ....|| | .|||. ||.| |. ||
isiivnelrkqrismvqnldqfifiYeall
|
|||||||||
| 0048179 | (Phosphotyrosine protein) phosphatases II | 305-411 | 1.7e-23 | 78.3 | In-house | 45-139 (144) | alignment | ||
Range on Protein: 305-411
Range on HMM: 45-139/144.0
ETRSVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHEritantkGSTPMLVHCSAGVGRTGTFISLYCMLaqvieESRVDIFGFIQKMRKDRPNMVQTAD
..| ..|... .|||.|||.... |.. . .....| . |.|||||||||||||.. .| |. . ..... .. .|. ||..|.. .
leregiqylhlpwpDhgvpdllellleflefieeale.......eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpg
QYILIHT
|.. ..
qlrfLle
|
|||||||||
| 0048567 | (Phosphotyrosine protein) phosphatases II | 306-410 | 8.6e-09 | 29.9 | In-house | 27-132 (157) | alignment | ||
Range on Protein: 306-410
Range on HMM: 27-132/157.0
TRSVHQF-------HYQSWPDMGvPQYPTTLISYTQTvkhVHERITANTKGSTPMLVHCSAGV---GRTGTFISLYCMLAQVIeesrvDIFGFIQKMRKD
. ....| .. . | | | ..|... . ... . .. . . |||.|| |||.|.|..|..| . . . .|. .|
lynalyFsiddglvyedfffdfG.PlnlailyrFilk...lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf.....tpeeaiaplriv
RPNMVQTADQYILIH
||..| |.. |..
rpgsvpfrdasylls
|
|||||||||
| subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 308-415 | 1.1e-13 | 45.2 | In-house | 219-342 (349) | alignment | ||
Range on Protein: 308-415
Range on HMM: 219-342/349.0
SVHQFHYQSWPDMGVPQYPTTLISYTQTVKHVH----ERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLA------------QVIEESRVDIFGFIQK
. |. .. |.|... | ... . ... | .|. ....||||||| ||||... | .|. .. . |. . .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne
MRKDRPNMVQTADQYILIHTALVE
.|| | .||| |.| |. ||..
lrkqrismvqnlaqfiaiyealLk
|
|||||||||
| PTPc_DSPc_SM00012 | 309-414 | 2e-35 | 116.5 | In-house | 2-104 (105) | alignment | |||
Range on Protein: 309-414
Range on HMM: 2-104/105.0
VHQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITAntkgSTPMLVHCSAGVGRTGTFISLYCMLAQVIEE-SRVDIFGFIQKMRKDRPNMVQTADQYI
|...|| .|||.|||.... .... . ||.... .. |.|..|||||||||||||. |...| |. .| ..|||| .....|| ||.|||| .||.
vkhyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqyl
LIHTALV
...||
flyrall
|
|||||||||
| DSPc | Dual specificity phosphatase, catalytic domain | 310-398 | 1.9e-07 | 26.0 | Pfam-A | 33-116 (133) | alignment | ||
Range on Protein: 310-398
Range on HMM: 33-116/133.0
HQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIeeSRVDIFGFIqkmRKDRPN
.... .. ....|. .| .. . . | | . .. |||| ||. |..|.| | | . . | . . |. ...|..
naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl..slneAyefv...kerrsk
|
|||||||||
| DSPc | Dual specificity phosphatase, catalytic domain | 310-398 | 1.9e-07 | 26.0 | In-house | 33-116 (133) | alignment | ||
Range on Protein: 310-398
Range on HMM: 33-116/133.0
HQFHYQSWPDMGVPQYPTTLISYTQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIeeSRVDIFGFIqkmRKDRPN
.... .. ....|. .| .. . . | | . .. |||| ||. |..|.| | | . . | . . |. ...|..
naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl..slneAyefv...kerrsk
|
|||||||||
| 0038934 | (Phosphotyrosine protein) phosphatases II | 313-407 | 1.4e-09 | 33.4 | In-house | 81-167 (194) | alignment | ||
Range on Protein: 313-407
Range on HMM: 81-167/194.0
HYQSWPDMGVPQYPtTLISYTQTVKHVHERITANTKGstPMLVHCSAGVGRTGTFISLYCMLAQVIeeSRVDIFGFIQKMRkdrPNMVQTADQYI
.| ..| .. | .| ... .. |.| . ....| .||| ||.|||||.. | . . . | . .... .| |..... |..
eylklpfpddgtvP.sleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYLiyrlgm..saeeAialfrekR...pgaipnqdyle
|
|||||||||
| subfamily_PTPDC1_pd | Subfamily PTPDC1 | 313-409 | 3.8e-09 | 31.2 | In-house | 86-168 (182) | alignment | ||
Range on Protein: 313-409
Range on HMM: 86-168/182.0
HYQSWPDMGVPQYPTTLisytQTVKHVHERITANtkgstPMLVHCSAGVGRTGTFISLYCMLAQVIEESRVdifgfIQKMRKDRPNMVQTADQYILI
. .|.| ||. . | . || |. .. . . ||| || |||| |. | . |. .. .. |...|. ||. .|| .| |.
ynfgwkDygvasleriL....divkvvafalqeg.....kvavhChaGlGrtGvliacylvyakrltaeka.....iklvrskrpksiqtreqvelv
|
|||||||||
| Y_phosphatase3 | Tyrosine phosphatase family | 315-380 | 5.2e-07 | 24.8 | Pfam-A | 92-154 (164) | alignment | ||
Range on Protein: 315-380
Range on HMM: 92-154/164.0
QSWPDMGVPQYPTTLISYTQTVKHVHERITANTkGstPMLVHCSAGVGRTGTFISLYCMLAQVIEE
.. .. . | . | ........| | . ... | |.|.||.|| ||| .. | |. | ||
eeaeeamaeayreiledekkayrkvlealaeee.g..pvlfHCtaGKDRTGvvaalllsllgvdee
|
|||||||||
| subfamily_DSP23_pd | Subfamily DSP23 | 319-410 | 4.6e-07 | 24.6 | In-house | 56-139 (148) | alignment | ||
Range on Protein: 319-410
Range on HMM: 56-139/148.0
DMGVPQY-PTTLisyTQTVKHVHERITANTKGSTpMLVHCSAGVGRTGTFISLYCmlaqvIEESRVDIFGFIQKMRKDRPNMVQTADQYILIH
.....| | .| | |. |. |. |. . . ||| | |||||... | . | .. | ..|. || |.| .| |..
rlriddyhppal...eqvvefvrvveeaeeknea.vsvhcllgrgrtgtmlacyl.....vkerklaaaeaiaevrrlrpgsvetveqeklvr
|
|||||||||
| PTPc_motif_SM00404 | 328-379 | 1.6e-08 | 29.5 | In-house | 58-109 (140) | alignment | |||
Range on Protein: 328-379
Range on HMM: 58-109/140.0
TLISYTQTVKHVHERITANTKGSTPMLVHCSAGVGRTGTFISLYCMLAQVIE
. .. . | . | . .| . |||| ||| |..|.| |.| . ..
ekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqls
|
|||||||||
| subfamily_PTEN_pd | Subfamily PTEN | 333-406 | 8.3e-07 | 24.2 | In-house | 99-171 (184) | alignment | ||
Range on Protein: 333-406
Range on HMM: 99-171/184.0
TQTVKHVHERITANTKgsTPMLVHCSAGVGRTGTFISLYCMLAQVIEESRvDIFGFIQKMRKDRPNMVQTADQ--Y
.. |..... . ...| . ||| || ||||. |. | . .. .|... .. . ...| . |. | |
eeivediekwleedkk..nvvvvHCkaGkGRtGvlivayllkslllekae.ealelfaeaRtknkkgvtiPsqrRY
|
|||||||||
| PTPlike_phytase | Inositol hexakisphosphate | 338-374 | 8.2e-06 | 20.5 | Pfam-A | 113-148 (149) | alignment | ||
Range on Protein: 338-374
Range on HMM: 113-148/149.0
HVHERITANtKGSTPMLVHCSAGVGRTGTFISLYCML
. . | . . .| ....|.|| ||| |.. ....|
afvrliksl.prdtalvfnCqaGrgRTTtamviadLl
|
|||||||||
| PTPlike_phytase | Inositol hexakisphosphate | 338-374 | 8.2e-06 | 20.5 | In-house | 113-148 (149) | alignment | ||
Range on Protein: 338-374
Range on HMM: 113-148/149.0
HVHERITANtKGSTPMLVHCSAGVGRTGTFISLYCML
. . | . . .| ....|.|| ||| |.. ....|
afvrliksl.prdtalvfnCqaGrgRTTtamviadLl
|
|||||||||
| subfamily_CDC14_pd | Subfamily CDC14 | 342-409 | 2.8e-07 | 24.7 | In-house | 257-317 (328) | alignment | ||
Range on Protein: 342-409
Range on HMM: 257-317/328.0
RITANTKGStpMLVHCSAGVGRTGTFISLYCMLAQvieesRVDIFGFIQKMRKDRPNMVQTADQYILI
.|. ...|. . ||| ||.|||||.|. | | |. | .| || .| . | |.
eiaekaeGa..iavhCkaGLGrtGtLiacylmkhy.....rftaaeaiawlricrPGsvigpqqkfle
|
|||||||||
| subfamily_CG42327_pd | Subfamily CG42327 | 349-414 | 6.3e-13 | 43.1 | In-house | 246-312 (319) | alignment | ||
Range on Protein: 349-414
Range on HMM: 246-312/319.0
GSTPMLVHCSAGVGRTGTFISLYcMLAQVIEES--RVDIFGFIQKMRKDRPNMVQTADQYILIHTALV
|. |||| ||||||. |. . . .||| ||| .. .|.|| . |.| .|| .|. |
sqGPlvvhcsdGvGrtGlviasd.iairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
|
|||||||||
| subfamily_Sponge-PTP-7_pd | Subfamily Sponge-PTP-7 | 353-418 | 2.5e-21 | 69.8 | In-house | 1-66 (69) | alignment | ||
Range on Protein: 353-418
Range on HMM: 1-66/69.0
MLVHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYM
|.||||.| |||||||.. .|.. | |||| .| ||| || || .||.|| |||||
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
|
|||||||||
| subfamily_Sponge-PTP7_pd | Subfamily Sponge-PTP7 | 355-420 | 2.3e-20 | 66.7 | In-house | 2-67 (69) | alignment | ||
Range on Protein: 355-420
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFISLYCMLAQVIEESRVDIFGFIQKMRKDRPNMVQTADQYILIHTALVEAYMSG
||||.| |||||||.. .|.. | |||| .| ||| || || ..|..|| ||||| |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
|
|||||||||
| subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 420-717 | 2.4e-74 | 245.3 | In-house | 1-297 (298) | alignment | ||
Range on Protein: 420-717
Range on HMM: 1-297/298.0
GNTDVPVSSFEAKLSSLQERNPLTQKLNIEQEFEILNQLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDV
|||.. .....|.|. |.. .. .. . ..||. ||. . . . ..| |.| .|||......... | | .. . .||||||||... ...
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna
FLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIKGP-KKGTLTVKQFQLMGWDgNQ
|.||| ||..|. | ||||.. . .||||..| .|| . .|||.. . ..| ..||. | |. .|...||.... .... .|.|.. . | ..
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskee.fadlivrklkvskkkeekerevrqlhftsWp.dk
KRPASLAPILHLVDAVSEcVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEYA
|. .|.|.. | .. |....| .|.|||| | ||.| |.. ....||.|| ||.||..|| .... .||. .|| . |... |....
gvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
|
|||||||||
| 0051299 | (Phosphotyrosine protein) phosphatases II | 420-711 | 2.8e-74 | 245.5 | In-house | 1-287 (288) | alignment | ||
Range on Protein: 420-711
Range on HMM: 1-287/288.0
GNTDVPVSSFEAKLSSLQernpLTQKLNIEQEFEILNQLTPPvgpQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDV
|.|...|.... . |. .... ....||| | .|.|. ..|| ||.|..|||....|| ...| .| . .. ...||||||..... .|
gdteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk
FLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIKG-----PKKGTLTVKQFQLMGW
|.||| |||.|..| |||| .....|||||..|. . . ||||||...|...|...| ..| |. .||..|..|.. ... ..||..|. ..|
fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnw
DgNQKRPASLAPILHLVDAVSECVRtsQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
.. | |. ..|... .| .. . . .||.| || .|.||.|.|.|.. . | . . ||... ||||| || |.....|| .|| ..||.|
p.dhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
|
|||||||||
| subfamily_PTPRB_pd | Subfamily PTPRB | 423-712 | 2e-58 | 192.7 | In-house | 6-287 (293) | alignment | ||
Range on Protein: 423-712
Range on HMM: 6-287/293.0
DVPVSSFEAKLSSLQERNpltqKLNIEQEFEILNQLTppvGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLA
.. ...||. ........ .|.. .|.| |... || ||| |..| .|||. |.|| ...| | . . ..|||||.... . . |.|
piklekfeehvkkmkads....dlrfseeyeelkavg...kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefia
TQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNK-DSVQFGPLKVSIISAETiRSDYVMRKFEIKGpKKGTLTVKQFQLMGWDgNQKRP
|| |||.|. |.|||| . .| .|||| .| . | | .|||.. ..|..| .||.... |. .|.|.|...|. .| . .|.|.. . | . |
tqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeee.ledwvirelkiek.ekeerkvrqyhftsWp.dhgvP
ASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
. ...|..| .| | ........||| || |.||.|.| |. ... .. |||| | .|| .| ... ...|| . .. . ....|
ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
|
|||||||||
| subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 424-718 | 7.4e-66 | 217.4 | In-house | 2-288 (318) | alignment | ||
Range on Protein: 424-718
Range on HMM: 2-288/318.0
VPVSSFEAKLSSLQErnplTQKLNIEQEFEILNQLTPPvgPQAFKAaGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLAT
..|. .| .. |.| . .|....|.| |.. . . ..|. |.| |||. |.|. .. | | .. . ..|||||.... . .| ..|.
isvedleshvrrlre....sGelllseeyerlsrseet..vtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaa
QMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDgNQKRPA
| |||.| | |||| . | ||||| .. . | ...|||.|.| ..| |.| . . . ||||.|.|... . . . .|.|.. | .. |.
qaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeeve.lsdyvlrefkvtrteeeesrqvrqyhytsWp.degvpe
SLAPILHLVDAVSECVRtSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEYAN
| | .|.|| ||. . .. |||| || |.|| ||| |. . |.. .. ||.|| ||.|| .|. |. ||| ..|. . |... .| ...
sgaslldlvrqvskaqq.ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
|
|||||||||
| subfamily_PTPRG_pd | Subfamily PTPRG | 424-711 | 2.5e-53 | 176.2 | In-house | 1-288 (563) | alignment | ||
Range on Protein: 424-711
Range on HMM: 1-288/563.0
VPVSSFEAKLSSLQERNpltqKLNIEQEFE-ILNQLTPPVGPqaFKAAGLPANIDKNRFPNVLPMEKNRPCLVT-KGEAGSTDYINASFLNTFIKKDVFL
|||. |. ..|| . . ...||| . .. .. . ... | | ||| |...... | | |. .. |||||.... . |.. |.
vpvkefakhvaslhadg....digfseefealqsetiskdld..aehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafi
ATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNKDSVQFGPLKVSIISAETIrSDYVMRKFEIKG-----PKK--GTLTVKQFQLMGW
||| ||..|. | |||. . .. .|||. .| . . . | .|||. .|...| |.| .|. |.. . | .|.. || |. ..|.|.. |
atqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevl.alytvrtlviknlklkkkkqcdteklvrqyhytkW
DgNQKRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
.. | . .| | | | . .. |||| || .|.||.|.. .. . ... ....|..|. .|..||.|. .... .|| .. . | ..
P.dhgvPehslpvLifvkkssaa..nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
|
|||||||||
| subfamily_PTPN6_pd | Subfamily PTPN6 | 428-715 | 1.2e-48 | 160.6 | In-house | 8-302 (306) | alignment | ||
Range on Protein: 428-715
Range on HMM: 8-302/306.0
SFEAKLSSLQERNPLTQKLNIEQEFEILNQLTpPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGStDYINASFLNTFI--KKDVFLATQM
. | . | |.. . ..| ..|.||| |.| | . | | |||. |.||....| | .. .|| |||||..... . .. ..|||
eieqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgs.dyinanyikkevkgsdksyiatqg
PLPHTTGDIWRMVCDWRSPVIVML-NELDLQDKSCAQYWPNKD-SVQFGPLKVSIISAeTIRSDYVMRKFEIK--GPKKGTLTVKQFQLMGWDgNQKRPA
|..| | |||| . | ||||. .|.. . ||.|||.. . ..| ..|. .| . .||..|.. .. || . .| |.. | .. |.
clettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWP.dhgvpk
SLAPILHLVDAVSECVRTSQ--ASGPIVLHCINGIGRSGVFAAI---YSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDE
. .|.... |.. .... .|||| || .|||| | | | . || .| .|| ..|| .|. | .. .|| . |. ...|... .
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
|
|||||||||
| 0039614 | (Phosphotyrosine protein) phosphatases II | 435-714 | 2.7e-69 | 229.2 | In-house | 21-293 (297) | alignment | ||
Range on Protein: 435-714
Range on HMM: 21-293/297.0
SLQERNPLTQKLNIEQEFEILNQLTPPvgpqaFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEA-GSTDYINASFLNTFIK-KDVFLATQMPLPHTTG
|. ......| ...||| | .|.|. .. | ||.|.||||....|| . .| .| .... ..||||||..... . .. |.||| |||.|..
lllllekansktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve
DIWRMVCDWRSPVIVMLNELDLQDKSCAQYWPNKDSvQFGPLKVSIISAETiRSDYVMRKFEIKGpKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDA
| |||| .....|||||..|. .. ||||||.. . ..|...| .. |. ...|..|..|.. .. ..||..|| .|| . | ||. .|.....
dFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkveh.ldgytvrtlevtn.ngesrtvthfqytgwp.dhgvppslellleflel
VSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD
| |...... .||.. || .|.||.|.|.|.| . | . . ||... ||.|| || .... .|| .|. ..|. |...
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
|
|||||||||
| subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 435-718 | 2.1e-54 | 179.5 | In-house | 9-286 (287) | alignment | ||
Range on Protein: 435-718
Range on HMM: 9-286/287.0
SLQERNPLTQKLNIEQEFEILNQLTPPvgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVtkgeAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDI
. .... . . . .. | .|.|.| .. . . | ||||. ..|. ...| | |||||.|.... .| |.... |. .| .
efvakghakgnegfknqftvleqvtqr..edevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf
WRMVCDWRSPVIVMLNE-LDLQDKSCAQYWPNKDSVQFGPLKVSIISAEtIRSDYVMRKFEIKGPK--KGTLTVKQFQLMGWDGNQKRPASLAPILHLVD
|... | . ..|||| . . ... | ||||...|| .|. ...... | . ..|..||.|.| . . ...|||.|. || . | . . .| . .
WkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillviee
AVSECVrtSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEYAN
. . .. ..|| || ...|||..| |. . .| |. .|.|| .|. | .| .. |.|| .. . ||.. |. |..
myktqr..krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd
|
|||||||||
| 0050432 | (Phosphotyrosine protein) phosphatases II | 436-715 | 5.7e-75 | 247.8 | In-house | 32-304 (308) | alignment | ||
Range on Protein: 436-715
Range on HMM: 32-304/308.0
LQERNPLTQKLNIEQEFEILNQLTPpvgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLvtkgeAGSTDYINASFLNTF--IKKDVFLATQMPLPHTTGD
|. ...... ..|.||| |....| . ...| ||.|.||||....|| ...| .| ...||||||. ... ... |.||| |||.|..|
lkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntved
IWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNK---DSVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILH
|||| .....|||||..|. . . ||||||.. .|...|...| ..| |. ..||..|..|.. .. ..||..|. ..| ... | |....|.
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWp.dhgvPpspeilld
LVDAVSECVrtsqASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDE
....| .. .|||| || .|.||.|.|.|.. . | . .. ||.|. ||.|| || |.....|| .|. ..||.|..
flelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
|
|||||||||
| 0045450 | (Phosphotyrosine protein) phosphatases II | 436-711 | 7.7e-66 | 218.2 | In-house | 17-305 (307) | alignment | ||
Range on Protein: 436-711
Range on HMM: 17-305/307.0
LQERNPLTQKLNIEQEFEILNQLTPPVgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEA-GSTDYINASFL--------NTFIKKDVFLATQMP
|. ...|. . ...||| |...|... . ...| ||.|.||||....|| . .| .| . .. ...||||||. .....|. |.||| |
lvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgP
LPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKDSV-QFGPLKVSIISAETiRSDYVMRKFEIKG--PKKGTLTVKQFQLMGWDgNQKRPAS
||.| | |||. .... |||||.||. .. ||||||..... ..|...| .| |. ..|..|..|.. ... ..||..|. || ... | |
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwp.dhgvpps
LAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSS---VDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
....|.....| ....... .||.. || |.||.|.|.|.| . . . .. ||... ||.||. || .... .|| .|| ..|. .
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
|
|||||||||
| 0047943 | (Phosphotyrosine protein) phosphatases II | 439-710 | 4.1e-71 | 235.0 | In-house | 5-272 (273) | alignment | ||
Range on Protein: 439-710
Range on HMM: 5-272/273.0
RNPLTQKLNIEQEFEILNQLTPpvgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLvtkgEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMV
...|... ...||| | .|.| . ...| ||.|.||||....|| ...| .| . |..||||||..... .| |.|||.|||.|..| ||||
lekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmv
CDWRSPVIVMLNELDLQDK-SCAQYWPNKD---SVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAV
.....|||||.||. .. ||||||.. |...|...| ..| || ..||..|..|.. . ..||..|. .|| ... |.||...|.....|
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwp.dhgvppslesllefielv
SECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
.. ... .||.| || .|.||.|.|.|.. . . ... ||... ||.|| || |.....|| .|| ..||.
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
|
|||||||||
| 0036941 | (Phosphotyrosine protein) phosphatases II | 439-714 | 7.5e-69 | 227.6 | In-house | 6-281 (297) | alignment | ||
Range on Protein: 439-714
Range on HMM: 6-281/297.0
RNPLTQKLNIEQEFEILnqlTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLvtkgEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMV
..|... ...||| | .| . ...| ||.|..|||....|| ...| .| . ...||||||..... | |.||| |||.|..| ||||
lekllflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmv
CDWRSPVIVMLNELDLQDK-SCAQYWPNK--DSVQFGPLKVSIISAETI-RSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAV
.....|||||.||. .. ||||||.. .|...|...| .| |.. .||..|..|.. .. ..||..|. .||. . | | |..|.....|
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp.dhgvpespaslldfielv
SECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMI---TDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD
.. . . .||.. || .|.||||.|.|.. . . . . |||.. || || || ......|| .|| ..|. ||..
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
|
|||||||||
| subfamily_PTPN14_pd | Subfamily PTPN14 | 440-712 | 1.8e-38 | 127.3 | In-house | 14-298 (300) | alignment | ||
Range on Protein: 440-712
Range on HMM: 14-298/300.0
NPLTQKLNIEQEFEILNQLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAgSTDYINASFLNTFI--KKDVFLATQMPLPHTTGDIWRM
. | .||. . | ..... ...| || | .||||..||| |.|| |.. |. ||.||||| ... . |. ....| ||..| | |.|
kilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqm
VCDWRSPVIVMLNELDL-QDKSCAQYWPNK----DSVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVD
| . .|||| | . . .|.|.. ..|.|| ||. |. . .. .....| | | || .| . | ... | . . |. ..
vWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsed.sdsvittglklkhlpskeertvwhlqytDWp.dhgvPeDvkgflsyLe
AVSE-CVRTSQAS------GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
| . .|.. . |...|| .|.||.|| . . .. ..|| ....||| | ...... || |. . .|.|.
evqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
|
|||||||||
| subfamily_PTPRN_pd | Subfamily PTPRN | 441-710 | 2.1e-43 | 143.1 | In-house | 24-292 (297) | alignment | ||
Range on Protein: 441-710
Range on HMM: 24-292/297.0
PLTQKLNIEQEFEILNQLTppVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLN-TFIKKDVFLATQMPLPHTTGDIWRMVC
|..| ..|.|.| | . |.. ..| . |..||| .||| ...| | .. .| ..||||||.. . .. ...||| ||..| |.|.||
hlknkdrlekewealcaye..aepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvw
DWRSPVIVMLNELDL-QDKSCAQYWPNKDSVQFGPLKVSIISAETIRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECV
. . |||.| .|. . | |..|||.. | .. .| ..| ||..| | .| . . | || || . | .. ||| ..|.. | .
eqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswp.eegvPasaksllefrrkvnksy
RTsqASGPIVLHCINGIGRSGVFAAIYSAAEKMITD-SSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
| | |||.|| .| ||.||. .| .... .|| ... || .|| .... ||. ... .|| .
rG..rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
|
|||||||||
| 0043336 | (Phosphotyrosine protein) phosphatases II | 442-710 | 9.7e-66 | 217.4 | In-house | 16-277 (278) | alignment | ||
Range on Protein: 442-710
Range on HMM: 16-277/278.0
LTQKLNIEQEFEILNQLTPpvgpQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDW
|. | ...||| |.. .. .. | ||.|.||||....|| . .| .| |. ..||||||..... ... |.||| |||.|..| |||| ..
lnlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel
RSPVIVMLNELD-LQDKSCAQYWPnKDSVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRt
....||||.||. |. . |||||| ..|...|...| .. |. .||..|..|.. .. ..|| ... .|| .. | ||...|... || |...
gvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavreale.
sQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
.||.. || .|.||.|.|.|.| . | . . ||... ||.|| ||..... .|| .|| ..||.
.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
|
|||||||||
| subfamily_PTPN23_pd | Subfamily PTPN23 | 442-713 | 1.2e-46 | 153.9 | In-house | 11-283 (288) | alignment | ||
Range on Protein: 442-713
Range on HMM: 11-283/288.0
LTQKLNIEQEFEILNQLTPPVgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVtkgeAGSTDYINASFLNTFIKK-DVFLATQMPLPHTTGDIWRMVCD
| .| .....|. |.| . . | . .|||. ..|| ..|| .| . |||||||.. |.||| ||. | .| |.|| .
ldgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye
WRSPVIVMLNEL-DLQDKSCAQYWPNK--DSVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSEC
.|.||||| . .|.......|||.. ..|.||.|.|.. | .. . .| |..... ... . .|. ||. | . ||| .|...|.| ..
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre.tethvervlkletldadavksvshlqltsWp.elGvPasPetllqfldevesa
VRTSQ--ASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSS-VDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKF
.. | . |.|.|| |.||.|||| .|.|.... .. .|| | |.|||..| |.. ..|. .|| . |. ..
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv
|
|||||||||
| subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 445-715 | 1.7e-62 | 206.3 | In-house | 22-289 (319) | alignment | ||
Range on Protein: 445-715
Range on HMM: 22-289/319.0
KLNIEQEFEILNQLTPPvgpqAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSP
. .|.||. |.. .. |. | . | .|||..|.|.... | | . . ..|||||||.... ... |.||| || .|. | |||| . .|
etllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess
VIVMLNELDLQDK-SCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIkGPKKGTL---TVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTS
..|||..| . | . .|||... ...| | | . . | .||..||... .|.. . .||.|| . | ... | .. .|.|. . . .. .
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeee.ledyiirklkl.nkkssevetRevkhfqyteWp.dhdvPekatslldllkrirksrekt
QaSGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD-E
| ||||| || .|.|| | | .. . |.. .. .|.|. |.|||. |. |.. .||...|| . |... .| |
q.sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte
|
|||||||||
| subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 445-708 | 9.8e-58 | 190.9 | In-house | 33-289 (319) | alignment | ||
Range on Protein: 445-708
Range on HMM: 33-289/319.0
KLNIEQEFEILNQLTPPVGPQAFkaAGLPANIDKNRFPNVLPMEKNRPCLV-TKGEAGStDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRS
. ..| || . .|... |.| | |. | ||||. |.|. .||. | . || .| |||||||.. . .|| ..|.| ||. | | |||. ....
ltklevefrracklgvnladqtf..anldqnkdknriinilafdknvvklerliGeefs.dyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync
PVIVMLNeldlqDKSCAQYWPNKDSVQFGPLKVSIISAETIRSdYVMRKFEIK--GPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQ
||.| . |.||||.| .. . ||.. | | ||.|..|. | .|. ..|| ..|| .. | . .... ||. |. . .
stivllt.....kdkcsqywplkivikeerfkvkvdsveetae.yvvrdielsedgkekdirkitqfhflGwp.dvGvpdypsdlmrlvkkvrhltsken
ASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAE
.||.|| |.||.||. .. ..| .. ||... |. || .|. ..... || ..| . |
hranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
|
|||||||||
| subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 445-712 | 5.2e-49 | 161.6 | In-house | 9-279 (287) | alignment | ||
Range on Protein: 445-712
Range on HMM: 9-279/287.0
KLNIEQEFEILNQLTpPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGStDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSP
| ....|.. | . . . |||| |.. |||. .|||....| |...|| || ||||| .. .. ... |.|.| |.. | .| ||.| . ||
kddvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGs.dyinanyvasytddeafiaaqgPiaatvrdfwravletrsa
VIVML-NELDLQDKSCAQYWPNKD-SVQFGPLKVSIISAETIRSDYVMRKFEIKGPKKG-TLTVKQFQLMGWDGNQKRPASLAPILHLVDA--VSECVRT
..... |.. . | .|||... .. | | ... . .| .| . . . . |||..|. | . |.... | .| | |
svitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielard
SQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
.. ||.|.|. ||||||.. |.. ... ||. . | ||| | ... .| |. . || .. | |
asevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
|
|||||||||
| subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 445-711 | 1.8e-38 | 127.1 | In-house | 5-260 (267) | alignment | ||
Range on Protein: 445-711
Range on HMM: 5-260/267.0
KLNIEQEFEILNQLTPPVGPQAFKAAglPANIDKNRFPNVLPMEKNRPCLVTKGEAgstdYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSP
. .||.||| ...... . | | ..||. ..|| ...| | || | |||||..... .| |..|| || | .| . .. | . |
eceiekefelikkisdtsstisqsia..eknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp
VIVMLNELDLQdkSCAQYWPNK--DSVQFGPLKVSiISAETIRSDYVMRKFEIKGPKKGTLTVKQFQLMGWDGNQKRPASLAPILHLVDAvsecVRTSQA
|||.| . ..|| | .. .. | | | | || . .|.| .. . | . |. | . | |.. .. . ..
vivlltkvftd..nirlfwPPkmgqakkyqdltve.hslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilak....nqleng
SGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
. |.|..| .|.|||| | |.| |.. |.. .|||. ....| |...... ..| ..| .||| .
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
|
|||||||||
| subfamily_ptpA1_pd | Subfamily ptpA1 | 445-663 | 1.1e-21 | 72.1 | In-house | 20-249 (418) | alignment | ||
Range on Protein: 445-663
Range on HMM: 20-249/418.0
KLNIEQEFEILNQltpPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDvFLATQMPLPHTTGDIWRMVCDWRSP
.|..|| .|.. ||| | |||. |.||... | | . .||||| ... |. |..|| ||| | |.|||| . |
ihkikeefrllee...svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcr
VIVMLN-ELDLQDKSCAQYWPNKDS-VQ----------FGPLKVSIISAE-TIRSDYVMRKFEIKgPKKGTLTVKQFQLMGWDGnQKRPASLAPILHLVD
.||||. | . | .|||.. | || | .. . . |. . . | . |.| || .. | |. .|.
iivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirlt.fegetrditqyqyegwpd.hnipdhtqpfrqllh
AVS----ECVRTSQASGPIVLHCINGIGRSGVFAAI
... . . .|. ||..|| |.||.| |..
sitnrqnqiipssdrnvpiivhcsagvgrtgtfcta
|
|||||||||
| 0040438 | (Phosphotyrosine protein) phosphatases II | 446-714 | 2.4e-69 | 229.3 | In-house | 18-280 (317) | alignment | ||
Range on Protein: 446-714
Range on HMM: 18-280/317.0
LNIEQEFEILNQLTPPvgpqAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPV
...||| | .|... .. | ||.|.||||.|..|| . .| .| |. ..||||||. ... .|. |.||| |||.|..| |||| .... |
talleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv
IVMLNELD-LQDKSCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRtsQAS
||||.||. |... ||||||.......|...| ..| |. .....|..|... .. ..||..|. .||. .. | |. ..|....|| |. . . .
ivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWp.dhgvppspdllldfleavreale..dpg
GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD
||.. || .|.||.|.|.|.| . | . . ||... ||.||. || .... .|| .|. ..||.|...
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
|
|||||||||
| subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 446-712 | 6.8e-19 | 62.4 | In-house | 26-287 (302) | alignment | ||
Range on Protein: 446-712
Range on HMM: 26-287/302.0
LNIEQEFEILNQLTPPVG-PQAFKaaglpANIDKNRFPNVLPMEKNRpclvTKGEAGSTDYINASFLNTF-IKKDVFLaTQMPLPHTT---GDIWRMVCD
....||. .... .. .||| .|..||. ..| ...|. |.|| .|.||| .. ... ..| .|.| .. . |||| .
aevkkefkkidtmkvdlekCkafk.....knlkknqsedvpildsnl....vkleaepdsyvnaskvevPeltrsiil.aQlpkvdsedsveeFWrmvfq
WRSP-VIVMLNELDLQDkSCAQYWP--NKDSVQFGPLKVSIISAETIRSDYVMRKFEIK--GPKKGTLTvKQFQLMGWDgNQKRPASLAPILHLVDAVse
. | ... | .|. . ...| | ...| . | . | . . |. | |. . | | ..| | . | . . . |
ekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvla.nvyvltnWk.qkkvpvkyaeliktaakv..
CVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
.....|. ..|. ||.|| |.| . | ||. ... . | . || .|..||....|..|| | .. |.||
fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
|
|||||||||
| subfamily_Sponge-PTP3_pd | Subfamily Sponge-PTP3 | 446-524 | 5.3e-10 | 33.4 | In-house | 19-94 (95) | alignment | ||
Range on Protein: 446-524
Range on HMM: 19-94/95.0
LNIEQEFEILNQLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEagsTDYINASFLNTFIKKDVFLATQ
| .|||. . . .. . ||| |||| |..| . | .| || . .||||| |.. . .|....|.|
snsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaq
|
|||||||||
| 0046845 | (Phosphotyrosine protein) phosphatases II | 447-715 | 1e-72 | 240.3 | In-house | 1-279 (284) | alignment | ||
Range on Protein: 447-715
Range on HMM: 1-279/284.0
NIEQEFEILNQLTPPVGpQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEA-GSTDYINASFLNTF-----IKKDVFLATQMPLPHTTGDIWRMVCD
..|.||| |..||... ...| ||.|..|||....|| ...| .| . .. ...||||||..... ..| |.|||.|||.|..| |||| .
gleeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe
WRSPVIVMLNELDLQDK-SCAQYWPNKD-SVQFGPLKVSIISAETiRSDYVMRKFEIKGP--KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSEC
....|||||.||. .. ||||||... ....|...| ..| |. ..||..|..|.. .. ..||..|. ..| ... |.|....|.....| |.
qnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswp.dhgvppspedlleflrlvrel
VRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDS---SVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDE
. . .|||| || .|.||.|.|.|.. . | ..... ||... ||||| || |.....|| .|| ..||.|..
lenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
|
|||||||||
| subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 447-710 | 8e-62 | 203.9 | In-house | 22-279 (288) | alignment | ||
Range on Protein: 447-710
Range on HMM: 22-279/288.0
NIEQEFEILNQLTppvGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVI
....|.. | .| .. .|. |. | .|||..|.||.. .| | | ..||||||... || ...||| ||..| .| |..| . .. |
gfseeynsLaale...ktksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktsti
VMLNEL-DLQDKSCAQYWPNKDS-VQFGPLKVSIISAETIrSDYVMRKFEIKgPKKGTLTVKQFQLMGWDGNQkRPASLAPILHLVDAVSECVRTSqaSG
|||.|| . ... | .|||..| ...| ..| ... .. |.|.||.... ||. |...|.| ..| .. |.| ||.|.|.. | .|
vmltelveggktkCeeYWPdadkpknyGsvtvtlveskel.edfvlrkllle.kkkteleitqyqylaWpdhg.vPeskapllellrqvkvanqad..tg
PIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
||. || .|.||.|.| |. . ... .. .|.. |..|| .|..... . || .|| ... .
piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
|
|||||||||
| subfamily_Ptp69D_pd | Subfamily Ptp69D | 447-714 | 1.3e-59 | 196.8 | In-house | 23-290 (307) | alignment | ||
Range on Protein: 447-714
Range on HMM: 23-290/307.0
NIEQEFEILNQLtppVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVI
...|.| |.. .. |.. | |||.... . .|.| | . ..|||||||.... .| |.| | |. | || |||. . . .|
glakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli
VMLNELDLQ-DKSCAQYWPNKDSVQFGPLKVSIISAETiRSDYVMRKFEIKGPK------KGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRT
||| .|. . .| ||.|||. | ||.| . | ..| |. |||..|.... | . . | |.. .||. . | | . .|.|.. | | ..
vmlsnlteknrkkcakYWpiedevqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykl
SqaSGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD
. .|||.|| .| ||||.| |. | ... .. .||||. || || .|. ...| .||. .| ...|... |
n..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd
|
|||||||||
| subfamily_CG7180_pd | Subfamily CG7180 | 447-711 | 1e-54 | 180.2 | In-house | 14-291 (296) | alignment | ||
Range on Protein: 447-711
Range on HMM: 14-291/296.0
NIEQEFEILNQLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVI
. . |.. . .||| . ... |..||| ..|.| ..||. | . . ..|||||.. ..|.|| .. |..| .| .. ||.| | . .
kfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisav
VMLNELDLQDKSCAQYWPNKDSVQFGPLKVSIISAETIrSDYVMRKFEI-----------KGPKKGTLTVKQFQLMGWDGNQKRPASLAPILHLVDAVSE
|.| . . | . .||||| |.|.. | |.. .. .. ..|.| . |. | | .||.||| |. ..| | | . ...|. |
vvLtktfdfakmypsywpnkskeqygeifveiveekqy.anlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl
CVRTS---QASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
.. . ||.| .. .| .||||. || . |... . ||.|. ||.|| .|| ..|.|..| .|. . |..
wrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
|
|||||||||
| subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 447-706 | 1.4e-48 | 160.3 | In-house | 7-262 (283) | alignment | ||
Range on Protein: 447-706
Range on HMM: 7-262/283.0
NIEQEFEILNQLTPPVGPQAFkaAGLPANIDKNRFPNVLPMEKNRPCLVTKGEagstDYINASFLN---TFIKKDVFLATQMPLPHTTGDIWRMVCDWRS
| . .| |..|. | . | | |||. ...|....| | .. . |||||.|. .. ....| || .| | |.|| | .
nnklfrevlkrlsvpdldadi..asadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki
PVIVMLNELDLQ-DKSCAQYWPNKDSVQFGPLKVSIiSAETIRSDYVMRKFEIKGP--KKGTLTVKQFQLMGWdgnqKRPASLAPILHLV--DAVSeCVR
|||| .| . .. |.||||.. |...|.. |.. || ...... .. | || . .|. .| |.| || . | .
taivmltklqedlrikCsqyWPkrGsedyGeftvtl.rkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvi.slq
TSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGM
| . ||||.|| .||||..|| |. .. ... |.| ||.|. || .| .|. .. . ||| . .| .
teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
|
|||||||||
| subfamily_PTPN13_pd | Subfamily PTPN13 | 447-711 | 1.1e-44 | 147.7 | In-house | 12-270 (273) | alignment | ||
Range on Protein: 447-711
Range on HMM: 12-270/273.0
NIEQEFEILNQLTPPVGPQAFKAAglpANIDKNRFPNVLPMEKNRPCLVTKGEagstdYINASFLNTFIKKDVF--LATQMPLPHTTGDIWRMVCDWRSP
. ..||. |..| | . | . .| ||||. ||||... | | .| |||||... . || . .|.| |||.|. |.|.|| . ..
qPaeefkelrelkpldtcevgkkk...enkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkae
VIVMLN-ELDLQDKSCAQYWPNKDS--VQF-GPLKVSIISAETiRSDYVMRKFEIKGPKKGT-LTVKQFQLMGWDgNQKRPASLAPILHLVDAVSEcvrT
||.|. | . . | .|||.. . .. . |.|. . . ....|.|....| . | | ..... | . . |.| |..|..| | .
viamvtlekekgkvkchrywPesknkklkvsnrlevellkvqk.ldgfvvralavkdsesgesrevahlnfvkwP.dhgvPssaaellqfvaevrr...l
SQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
. .|||| || ||||||.. .|. . . . | ..|. . |..|| | ... . ||| .|. . | .|
qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
|
|||||||||
| DSPc_SM00195 | 448-711 | 9.4e-67 | 220.5 | In-house | 2-263 (263) | alignment | |||
Range on Protein: 448-711
Range on HMM: 2-263/263.0
IEQEFEILNQLTPPVgpqAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
...||| |.. |.| .. | ..| .|||. |.||....| | .. . ..|||||..... || . |||.|||.| | |||| . ....||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv
MLNELDL-QDKSCAQYWPNK--DSVQFGPLKVSIISAETIRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRTSqaS
||.| . . . |..|||.. .. .|| ..| ... |. ......|..|.. . . | .|.|.| .| . . | | ..|.|. || .. .|| |
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkksksts..s
GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
|||| || .|.||.|.|..| .. .|. ... ||||. ||.|| .||.|... .||...|| ..||.|
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
|
|||||||||
| PTPc_SM00194 | 448-711 | 9.4e-67 | 220.5 | In-house | 2-263 (263) | alignment | |||
Range on Protein: 448-711
Range on HMM: 2-263/263.0
IEQEFEILNQLTPPVgpqAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
...||| |.. |.| .. | ..| .|||. |.||....| | .. . ..|||||..... || . |||.|||.| | |||| . ....||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv
MLNELDL-QDKSCAQYWPNK--DSVQFGPLKVSIISAETIRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRTSqaS
||.| . . . |..|||.. .. .|| ..| ... |. ......|..|.. . . | .|.|.| .| . . | | ..|.|. || .. .|| |
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkksksts..s
GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
|||| || .|.||.|.|..| .. .|. ... ||||. ||.|| .||.|... .||...|| ..||.|
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
|
|||||||||
| subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 448-714 | 3.9e-57 | 188.7 | In-house | 24-287 (305) | alignment | ||
Range on Protein: 448-714
Range on HMM: 24-287/305.0
IEQEFEILNQLtppvgPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
.|.... | .. ..... || |||. .. .....| | .| . . .||||||..... .|. ....| ||..| | ||.. . . .||
leaqykslyee.....eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv
MLNELDLQD-KSCAQYWPNKDSV--QFGPLKVSIISAEtIRSDYVMRKFEIKG--PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQa
|| .| .. . | ||||.. . .||...| . | . |||..||..| .| . || |.|| | .. | . . .|.|.. | . . ..
mltklveggkdkCrqYWpesktekkefgefsvelksek.tasdyieRklkisiededkesrtvlqyqltdWP.dhGvpqfatsllslikrvqkdqkkdk.
SGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFD
|.. || .|.||.||| |. | |.. .. .||.|. .|.|| .|. |... ||| ... ..|... .|
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
|
|||||||||
| subfamily_PTPN9_pd | Subfamily PTPN9 | 448-712 | 1.7e-50 | 166.7 | In-house | 18-292 (297) | alignment | ||
Range on Protein: 448-712
Range on HMM: 18-292/297.0
IEQEFEILNQlTPPVGpqAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
. .|.. . . .|..| |.|. |.||. |||. .|| ... | | .. | .|||||.|.. . .|. |.||| ||..|. | |||| . . |||
lskeyaeirn.epveG..tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv
MLNELD-LQDKSCAQYWP--NKDSVQFGPLKVSIISAETiRSDYVMRKFEIKGPKK-GTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSE--------
| . . |.|||| ...| .|| |.|| .. |. ..||..|..||| |. . .| ||...| . | | | .|.....| |
mttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.eedykvrvleiknvkteesrkvthfqflsWP.dyGvPssaaslldvlekvrekqalavke
---CVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
. |||.|| ||||.| |... . ... . . ||....||.||. | .| .|| || . || ..
lgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
|
|||||||||
| subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 448-711 | 5.7e-35 | 115.6 | In-house | 22-280 (439) | alignment | ||
Range on Protein: 448-711
Range on HMM: 22-280/439.0
IEQEFEILNQLTPPVGPQAFKAAGlPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
....|| .| |. .| || . |||. .| ... | | . |||| ... . ......|||.| .|| | ||.| . .. ||
fkeifekinstspdyaciaslaaq.eydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtiv
MLNELDLQDKscaqYWPNKDSVQFGPLKVSIISaETIRSDYVMRKFEIKGP---KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSEcVRTSQASG
|| .| | ||| .. | .| . | . . .||.| | . . || ||. . | ... || . .|... |. .. |
mltnlvesyk....ywpsdaevcygdiavrvdr.nielpnyvirgfkvfnerdttekertvlqfhyiawp.dknvpaqashvldflrains.andkeeyg
PIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
|.|.|| |.||.| |. | |.. .. ||| || || .| |.... || . |. . | ..
pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
|
|||||||||
| subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 448-710 | 4.2e-27 | 89.9 | In-house | 18-277 (307) | alignment | ||
Range on Protein: 448-710
Range on HMM: 18-277/307.0
IEQEFEILNQLTPP-VGPQAFKaaglpANIDKNRFPNVLPMEKNRPCLVTKGEagSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVI
. .||..| . || | .||. || ||||. .| ..|.| . ..| ..||| | .| . || |...| || | ..| |. . . .
lvdefrvlakktpegvtveafs.....antdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv
VML-NELDLQDKSCAQYWPNKDSV--QFGP----LKVSIISAETIRSDYVM---RKFEIKGpKKGTLTVKQFQLMGWDGNQKRPASLAPIlHLVDAVsec
.|| . ..| | |||| .. || . |. . |... | . ..... ... |....| | . . |. | |..||
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltai.nlleav...
vRtsQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDS-SVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
| |.|.|| |.|||| || .|||. |. . |. ||..|. |.. || . . ||.
.r..ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
|
|||||||||
| subfamily_egg_pd | Subfamily egg | 448-708 | 3.7e-21 | 70.1 | In-house | 16-268 (307) | alignment | ||
Range on Protein: 448-708
Range on HMM: 16-268/307.0
IEQEFEILNQLtppVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIV
.|. .|.|... | .... | | .| | . | . | | . . |.| | .. . |. .| || | | |||| . . ||
lerrlevlees...vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyiv
MLNELdLQDKSCAQYWPN--KDSVQF--GPLKVSIISAETIR-SDYVMRKFEIKGPKKGTLTVKQFQlmgWDGNQkrPASLAPILHLVdavsEcvRTSQA
||. . . | |||. .||... | |.. . . . . |. . |... . .. .| .| |. . . |... . ..
mltsr.keserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq...gdvnn..ssdvysplrvl....r..klrnl
SGPIVLHCINGIGRSGVFAAIYSAAEKMITDS--SVDIFQSVKRLRANRPSMIESVDQYSICYEGMAE
| |.|...|.|. ..... || | ... . ..|. || .|. .||| .| | ..
skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
|
|||||||||
| subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 449-717 | 1.6e-21 | 71.2 | In-house | 27-298 (305) | alignment | ||
Range on Protein: 449-717
Range on HMM: 27-298/305.0
EQEFEILNQLTPPVGPQ-AFKAAGLP-ANIDKNRFPNVlPMEKNRPCLVTKGEagSTDYINASFLNT-FIKKDVFLATQMPLPHTTGDIWRMVCDWRSPV
.|| | . | | | ||.| . .| |||. .| | . . .. | .||| | .. .| . |...| || .| ..| || . .
reefrglakytrpdmtqvafnanqsadiaitknryqdv.pcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveq
IVMLN-ELDLQDKSCAQYWPNKDSVQFgPLKVSIISAETIRSDYVMRKFEIK-------GPKKGTLTVKQFQLMGWDGNQKRPASLAPiLHLVDAvsecV
|||| ..| |||||| . || |. . | . | ||. . ...|...| | |. |. | |. | .
ivmlcktvelgklkcaqywpaaqgekl.elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppcklts.lellsa....i
RTSQAsgPIVLHCINGIGRSGVFAAIYSAAEKMITDSSV-DIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM-KKF-DEYA
| |. |||.|| ||||.| || ||. . .. . . || || .| |.. || . | .|. .|. . ||
rgskv..pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekya
|
|||||||||
| subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 451-708 | 2e-56 | 186.6 | In-house | 3-253 (284) | alignment | ||
Range on Protein: 451-708
Range on HMM: 3-253/284.0
EFEILNQLTPPVGPQAFkaAGLPANIDKNRFPNVLPMEKNRPCLV-TKGEAGStDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML
|| . .|... |.| | |. | ||||. ..|. .||. | . || .| |||||||.. . .|| ..||| ||. | | |||. . .. ||.|
efrracklgvngtdqtf..anldqnkdknrighilafdknvvklerliGeefs.dyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivll
NeldlqDKSCAQYWPNKDSVQFGPLKVSIISAETIRSdYVMRKFEIK--GPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQASGPIV
.. |.||||.| .. . ||.. | | ||.|..|. | .|. ...|| ..|| .. .| . .... ||. |. . . .||
t.....kdkcsqywplkivikeerfkvkvdsveesee.yvvrdielsedgkekdirkirqfhflgwp.dvgvpdypsdlmrlvkkvrhltskenhraniv
LHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAE
.|| |.||.||. .. ..| .. ||... |. || .|....... || ..| . |
vhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
|
|||||||||
| subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 451-713 | 5.9e-29 | 95.6 | In-house | 30-286 (290) | alignment | ||
Range on Protein: 451-713
Range on HMM: 30-286/290.0
EFEILNQLTPPVGPQAFKAAGLPANI--DKNRFPNVLPMEKNRPCLvTKGeaGSTDYINASFLNTFikKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVM
| |..| | . | .. . .| |||. .| .| | | | . ||. | ... | .|. || .| |. |||||| . . .|||
akeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvil.kdG..ydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivm
LNELDLQDK-SCAQYWPNKD--SVQFGPLKVSIISAETIRSDYVMRKFEIKGPKKGT-LTVKQFQLMGWDGNQkRPASLAPILHLVDAvsecVRTsqASG
| || . | |.||.|.|. . || . | .. .. ... . .. ..| .| .... | . . | .| .. . .|. |||
lceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks.valstlallrtlri....lrk..asG
PIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKF
|.|.|| ||||.| |.|| ... .. ..|. . |. || | . .. || . | . .. |.|
pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
|
|||||||||
| 0045098 | (Phosphotyrosine protein) phosphatases II | 456-713 | 3.4e-59 | 195.8 | In-house | 14-275 (278) | alignment | ||
Range on Protein: 456-713
Range on HMM: 14-275/278.0
NQLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPClvtkgeagstDYINASFLNTFikKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNE-LDL
.| .. |. . | .. |.||||....|| . .| . ||||||..... .. |.||| |||.|. | |||. .....|||||.| ..|
efllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel
QDKSCAQYWPNKDSVQFGPLKVSIISAETIrSDYVMRKFEIKG-----PKKGTLTVKQFQLMGWDGNqKRPASL--APILHLVDAVSECVR---------
. . ||||||...|...|...| ..| |.. .||..|.... . ...|.......|. . | . ...|.|.. . |...
grekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdh.gvpslpilksflellefirealkllaslllss
--TSQASGPIVLHCINGIGRSGVFAAIYSAAEKMitDSSVDIFQSVKRLRANRPS-MIESVDQYSICYEGMAEYMKKF
. . .||.. || |.||.|...|.| | . .. ||... || || || .... .|| .|| ..|. ...
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
|
|||||||||
| subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 457-711 | 1.2e-142 | 469.8 | In-house | 30-289 (325) | alignment | ||
Range on Protein: 457-711
Range on HMM: 30-289/325.0
QLTPPVGPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQD
.|.|.....|.|.|..|.|..||||.||....|.|..|.||....|.||||||.|....|||||||.|.||..|..|.||.|.|||..|.|.||||||..
gllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgk
KSCAQYWPNK--DSVQFGPLKVSIISAETIrSDYVMRKFEIKGPKKG-TLTVKQFQLMGWD--GNQKRPASLAPILHLVDAVSECVRT-SQASGPIVLHC
..||.|||.. .|..||.|.|.....|.| ||||.|....|..||| |..||||||..|| |.|||||.|..||.||.||||.|.. ..||.||..||
drcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc
INGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
..|.||.|||...|||..|.|..|.||||..||.||..||||.|.||||...||...|..
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
|
|||||||||
| subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 459-568 | 2.6e-21 | 70.5 | In-house | 31-147 (392) | alignment | ||
Range on Protein: 459-568
Range on HMM: 31-147/392.0
TPPVGPQafKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQD--
|.. || ..| . |. |||. |.||....| | . .||.|||....| . ..|.|.| . . |.|||| . . |.|...|. |
gpdiypq..tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkg
---KSCAQY----WPNKDS
...||. ||.||
ddartvaqfhftewPdkdv
|
|||||||||
| subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 460-711 | 3.4e-59 | 195.2 | In-house | 31-278 (315) | alignment | ||
Range on Protein: 460-711
Range on HMM: 31-278/315.0
PPVGPQafKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-S
|.. .| ..| . | |||. |.||....| | . ||||||..... . ..|.|.||. . | |||| . . |||..... .|| .
Pdiyrq..rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik
CAQYWPN--KDSVQFGPLKVSIISAETIrSDYVMRKFeIKGPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGR
|.||||. |||.|| .||...| |. .| |.||. . . . || |||. .| .. . .. .|.|. .| . ....|| |.||
crqywPdrkadsvefGsikvellslead.tdgvarkl.vtrkseesrtvtqfqftewP.dkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGr
SGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
.||. .| . ... .|||.|. || |||.|| .. . ..|. |. . |...
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
|
|||||||||
| subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 463-570 | 1.2e-12 | 42.0 | In-house | 84-185 (244) | alignment | ||
Range on Protein: 463-570
Range on HMM: 84-185/244.0
GPQAFKAAGLPANIDKNRFPNVLPMEKNRPCLvTKGEAGSTdYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDkscaQY
| .| | | | ||| ||.. || | .|| | | ||||||. . . .. || || |. |.|.|. . |.|.| .. .| .|
dpsvmkdafnpnnswknregaglpfdfnrvpl.skgsmgnt.yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....ey
WPNKDSVQ
||. . ..
wpdseple
|
|||||||||
| subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 464-569 | 7.4e-13 | 43.0 | In-house | 22-128 (297) | alignment | ||
Range on Protein: 464-569
Range on HMM: 22-128/297.0
PQAFKAAGLPANIDKNRFPNVLPMEKNRPCLvtKGEAGSTDYINASFLnTFIKKD---VFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SC
...| .| .. . |||. ..| ....| | .. .||||| .. .| ... .. .| || | | |..| . ||||. .| . . |
gesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyv.vfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc
AQYWPNKDSV
| |||. .
apywpsvvqe
|
|||||||||
| subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 465-712 | 6.6e-46 | 151.7 | In-house | 31-278 (281) | alignment | ||
Range on Protein: 465-712
Range on HMM: 31-278/281.0
QAFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML-NELDLQDKSCAQYW
.. .|. ..|. |||. |. .. | . . |. .||||||.|.... .. ..||| |.|.. . |.|| . . .|||. .|.. | .||
ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYW
PNKD-SVQFGPLKVSIISAETiRSDYVMRKFEIKGPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQAsGPIVLHCINGIGRSGVFAA
|... ....| ..|. ...|. .. |. |||... . | .|.|.. . | .. ||. . .|. ..| .. .... |.|.|| |.||.|.. |
Pddnselkygdvtvkstaeee.katyierkfkleresgetreveqlaytaWP.dhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtGtyia
IYSAAEKMITD-SSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
. ..... .. ...|. . |. || .| |. .| ||. | . ....|
lDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
|
|||||||||
| 0049772 | (Phosphotyrosine protein) phosphatases II | 465-714 | 7.1e-36 | 119.9 | In-house | 36-284 (314) | alignment | ||
Range on Protein: 465-714
Range on HMM: 36-284/314.0
QAFKAAGLPANIDKNRFPNVLPMEkNRPCLvTKGEAGSTDYINASFLNTFikkDVFLATQMPLPHTTGDI----------WRMV--CDWRSPVIVM----
. ...| |..|.||||....||.. || .| . . ..||||||....| |.||| ||..| |. |||| |... .|||
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde
-----------------LNELDLQDkscaqywPNKDSVQFGPLKvsiisaetirsdyvmrkFEIKGPKKGTLTVKQFQLMGWDGnQKRPaSLAPILHLVD
|..|| . . . . || |. |.. . .. .. . ... | .|. ......
vladelsrLdaAlgKtpllildgng.......neptaadlellk.................eelydpelferlgikylripvpD.gsap.lledfdefle
AVSECvrtsQASGPIVLHCINGIGRSGVFAAIYSAAEKMitdsSVDIFQSVKRLRANRP-----SMIESVDQYSICYEGMAEYMKKFD
.. |. .. ||.. || |.||.|.|.... .. |.. . ....|. || ..||. .|| ..| . ||.|..
fieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
|
|||||||||
| subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 465-712 | 1.4e-19 | 65.0 | In-house | 41-289 (305) | alignment | ||
Range on Protein: 465-712
Range on HMM: 41-289/305.0
QAFKAAglpANIDKNRFPNVLPMEKNRPCLvtkGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML-NELDLQDKSCAQYW
.||| | . .|||. .| ...|| | . .|| | .. | . |. || || .| |.| | . . | || | |. | |..|.
kafkea...qeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyf
PNKD--SVQFG--PLKVS--IISAETIR--S--D--YVMRKFEIKGPKKGTLTVKQFQLMGWDGNQKrPASLAPILHLVDavsecvRTSQASGPIVLHCI
. || ..| |.| . |..|.. . . .. |.|| . .. |... . | ||. || |. .. . ||||.||
askdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgv.paadlailelle......karpskgpivvhcs
NGIGRSGVFAAIYSAAEKMITDSSVDIFQ-SVKRLRANRPSMIESVDQYSICYEGMAEYMKK
||||.| . ..... .. . ....| .| |.. .|| . .. . .|..|
agigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
|
|||||||||
| subfamily_PTPRA_pd | Subfamily PTPRA | 466-711 | 3.3e-60 | 198.7 | In-house | 49-296 (330) | alignment | ||
Range on Protein: 466-711
Range on HMM: 49-296/330.0
AFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDL-QDKSCAQYWP
....| | .|||..|.|| . .| | .| ..|||||||.. . .|| |.|.| |. .| | |||. ...| |||| ||. ... ||||||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP
NKDSVQFGPLKVSIiSAETIRSDYVMRKFEIK-----GPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGRSGV
.. .| .| ..|.. ||. || .||| .. .| . |.|| . .| . |. .|.|. .| .. | .||||.|| |.||.|
deGlvtyGnirvev.edetvlvdytvrkflvqqlpdatrekksrlvrqfhftswP.dvGvPfepiGmlkllkkvkkl..nqqsagpivvhcsaGvGrtGt
FAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
| .. . |.. .. ||.|. |||||..|| |. . || .|. . ||
fivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
|
|||||||||
| subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 466-716 | 1.6e-56 | 186.3 | In-house | 37-289 (290) | alignment | ||
Range on Protein: 466-716
Range on HMM: 37-289/290.0
AFKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEA--GSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQY
. . . . | .||| |... . || | ... . .||||.... . .| ..||| |...| | |... . ....|||| . . . . | ||
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY
WPNKDSVQFGPLKVSIISAETIRsDYVMRKFEIKGPKK--GTLTVKQFQLMGWDGNQKRPASlAPILHLVDAVSECVRTSQaSGPIVLHCINGIGRSGVF
||..|. ..|. .. ... ||. .|. ||.|.| .. . .|.|.|. || . | .. . ||... . . | . ..||.|| ...|||.||
Wpdsdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnp.qtillvieemyktqrkrg.ntsivvHCSdtvgrsavf
AAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEY
|.. . .|. |. .|.|| .|..| .| ....|.|| . .. . .|...|. |
caaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
|
|||||||||
| subfamily_PTPN3_pd | Subfamily PTPN3 | 466-710 | 4.3e-45 | 148.8 | In-house | 32-276 (280) | alignment | ||
Range on Protein: 466-710
Range on HMM: 32-276/280.0
AFKAAGLPANIDKNRFPNVLPMEKNRPCLVtkgeAGSTDYINASFLNTFIKK----DVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQ-DKSCA
| .|| .|.|..|||. ..|| .. | |. ...||||||...| | ..||| ||..|. | |.|| . .| .|||| .| . . |
aisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh
QYWPN-KDSVQFGPLKVSIISAeTIRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVrtSQASGPIVLHCINGIGRSG
||||. .|....| ..| . . .. ||.|.. .| . | .. |.| . | ... | . | .|..|. | .. | .. |.|.|| ||||.|
qyWPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWp.dhgvPddsadflefvervrklr..sgkeePvvvhCsaGigrtG
VFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEG-MAEYM
|. .. | .. . .| . . |...| | .......|| | .. |.
vlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
|
|||||||||
| subfamily_PTPRD_pd | Subfamily PTPRD | 467-716 | 3e-74 | 245.6 | In-house | 40-287 (564) | alignment | ||
Range on Protein: 467-716
Range on HMM: 40-287/564.0
FKAAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPN
..|| ||| |||. |... ...| .| . ..|||||||.... |. ..||| ||..|. | |||| . .| .||||..| ..| |..|||.
weaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPe
KDSVQFGPLKVSIISAETIrSDYVMRKFEIKGP-KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVrTsQASGPIVLHCINGIGRSGVFAAIY
|.. ..| |.|.. . |.. .||..|.|..| .. . .|.||. . | .. | | ...|.|.. |... . . .|||| || .|.||.|.| .|
kgtetygeltVtleeeeel.adyeirtfklkkkkssesreVrqFhFtsWP.dhgvpesatslLdlirkvraln.e.pdagPivVhCSaGVGRTGtfivid
SAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEY
. |.. .. |||.| ||.||..|. |... .||. ..| ..|.......
amlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
|
|||||||||
| subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 467-707 | 7e-20 | 65.8 | In-house | 29-266 (281) | alignment | ||
Range on Protein: 467-707
Range on HMM: 29-266/281.0
FKAAGLPANIDKNRFPNVLPMEKNRPCLVT-KGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWP
. | | |||. |. .. | | . ||||| | .. . . | .. || | | |.|||. . . |||| .. . . . ||.|.|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp
NKD--SVQFGPLKVSIiSAETIRSDYVMRKFEIKGPKKgTLTVKQFQLMGWDGNQkRPASLAPILHLVDAVsecvRTsqASGPIVLHCINGIGRSGVFAA
. .|| | || |. | .... . | . .. | | | | .|... . |. | | |.|| |.|||| . |
rnahcclqfdklsvsy.edstvnkslvttrlnlsyege.trlithwlwkewpdwq.vpessevmlkilrki....ra..rstppvihcsagvgrsgtlma
IYSAAEKMITDSS-VDIFQSVKRLRA-NRPSMIESVDQYSICYEGMA
. | . . . . || | | .|| | . .....|| . .. .
veialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
|
|||||||||
| subfamily_PTPN1_pd | Subfamily PTPN1 | 468-715 | 2.1e-37 | 123.4 | In-house | 25-276 (290) | alignment | ||
Range on Protein: 468-715
Range on HMM: 25-276/290.0
KAAGLPANIDKNRFPNVLPMEKNRPCLvtkgEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNK
..| ||.| ..||. .| | .. | | | ...||||||... | .. || |||.|.. |.|| . .| .||||.. . . ||||||..
reaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg
DS---VQFG--PLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVF
.. ... ||| .|| |. .| |..|..|.. . | .. .| . | . | | | |... | |. |. || |.|| |||||| |
eeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwp.dfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtf
AAIYSA---AEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDE
. . . || ||||| . . || | .| || | . | .|. .
clvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikg
|
|||||||||
| subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 468-549 | 2.3e-06 | 21.4 | In-house | 30-116 (347) | alignment | ||
Range on Protein: 468-549
Range on HMM: 30-116/347.0
KAAGLPANIDKNRFPNVLPMEKNRPCLVT-KGEAGSTD----YINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML
.. ...||| .| ... | | | . . .| ||||| .. . .. || |||.| |.|.|| . .| .
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
|
|||||||||
| 0037934 | (Phosphotyrosine protein) phosphatases II | 469-709 | 1.4e-55 | 183.9 | In-house | 4-241 (243) | alignment | ||
Range on Protein: 469-709
Range on HMM: 4-241/243.0
AAGLPANIDKNRFPNVLPMEKNRPCLvtkgeAGsTDYINASFLNTFiKKdvFLATQMPLPHTTGD----IWRMVCDWRSPVIVMLNELD-LQDKSCAQYW
| ||.|..|||....||.. .| .| | .|||||.. . . .. . |||.|||.|. | |||. .... |||||.||. |. . |||||
iallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw
PnkDSVQFGPLKVSIISAETiRSDYVMRKFEIKG--PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRT------SQASGPIVLHCINGIG
| ..|..|...| ..| |. .||..|..... ... |..| ... ..| .. | | ...| ..|.| |... .||...|| |.|
p..gevtygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg
RSGVFAAIYSAAEKMitdsSVDIFQSVKRLRANRPS-MIESVDQYSICYEGMAEY
|.|...|.| ... .||... ||.||. || .... .|| .|| ..|.
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
|
|||||||||
| subfamily_PTPN12_pd | Subfamily PTPN12 | 469-712 | 3.4e-55 | 182.0 | In-house | 34-279 (290) | alignment | ||
Range on Protein: 469-712
Range on HMM: 34-279/290.0
AAGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML-NELDLQDKSCAQYWPNK-
|. . |. |||. ..|| .|.| | .. | |||||.|.. .| ..|.| |||.| | |||. . . ..||. .|..|. | |..|||..
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg
-DSVQFGPLKVSIISAETIRSDYVMRKFEIKGPkKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRtsQASGPIVLHCINGIGRSGVFAAIYS
....||...|. .. ... |...| .... | . .|.||. . | .. .|.| ..|.|...| | . . . |.|.|| |.|| |. ||
eeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWP.DhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidy
AAEKMITD---SSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
. | . .. ...|.|. | .|| .|.... . .||.. |. .||...|
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
|
|||||||||
| 0040439 | (Phosphotyrosine protein) phosphatases II | 470-711 | 2.4e-62 | 206.1 | In-house | 6-247 (249) | alignment | ||
Range on Protein: 470-711
Range on HMM: 6-247/249.0
AGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQ-DKSCAQYWPNKDS
| ||.|.||||.|..|| . .|..| .. .||||||..... |. |.||| |||.|..| |||. .... |||||..|. . ||||||...|
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs
VQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAA
...| ..| .| |. .||..|..|.. .. ..||...| .| .. | |....| ...|| ..... .||.. || .|.||.|.|.|.| .
leygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml
EKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
| . . ||... || || || .... .|| .|| ..|. .
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
|
|||||||||
| 0042113 | (Phosphotyrosine protein) phosphatases II | 470-711 | 4e-60 | 198.6 | In-house | 4-244 (245) | alignment | ||
Range on Protein: 470-711
Range on HMM: 4-244/245.0
AGLPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELD-LQDKSCAQYWPNKDS
| ||.|.||||....|| . .| .| |. .||||||. ... .. |.||| |||.|..| |||. .... .||||.|.. |. . ||||||...|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges
VQFGPLKVSIISAETiRSDYVMRKFEIKG-PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTsQASGPIVLHCINGIGRSGVFAAIYSAA
...| ..| .| |. .||..|..|.. ... ...| ... ..|. .. | .|. .| ....| .... ..||.. || |.||.|.|.|.| ..
ltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwp.dhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylml
EKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
| . . |.... ||.|| || .... .|| .|| ..|..|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
|
|||||||||
| subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 470-710 | 1e-17 | 58.8 | In-house | 42-279 (303) | alignment | ||
Range on Protein: 470-710
Range on HMM: 42-279/303.0
AGLPANIDKNRFPNVLPMEKNRPCLvtkgeaGSTDYINASFLNTFIKKDVFLaTQMPLPHTTGDIWRMVCDWRSP-VIVMLNELDLQDKSCAQYWP-NKD
. |.||||| .|. ... . | . || ||.|. .| | ||.||.||. |.|.|. . . |...| . . .. .| |.|
nqfvknmdknrfvdvicldhskvkl......sdssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd
SVQFGP--LKVSIISAETIRSDYVMRKFEI-KGPKKGTLTVKQFQlmGWDGNQKRPASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIY
..| ..| . . .|.. . .| | | |.... | |. . . ... . . .| | | | . | ||.| || .
flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfe
SAAEKMIT-DSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
.| . . ..|.|. . .. .| | .. . |.|. | .||..
tahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
|
|||||||||
| subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 471-712 | 9e-50 | 164.3 | In-house | 24-270 (274) | alignment | ||
Range on Protein: 471-712
Range on HMM: 24-270/274.0
GLPANIDKNRFPNVLPMEKNRPCLVT-KGEAGSTDYINASFLNTFI-KKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKD
.. . |||. ..|| |. | .| . ..|. ..|||| .. . .. ...||| |||.| | |||. ...||||| .| ... ||.|.|..
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae
SV----QFGPLKVSIISAeTIRSDYVMRKFEIKGPKKgTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQAS-GPIVLHCINGIGRSGVFAA
.. ..| ... . .. . | || .||. .| .. . .|| . | ..| | . ..|.||. |.| ....| .|.|.|| |||| |.| |
dyeiserygdveikveki.verndysvrklvlkyler.ersvkhywytdWP.dhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfia
IYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
| | .. .. ||... | || .| |... .|| . .. ...|.|.
isiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
|
|||||||||
| subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 472-718 | 3e-64 | 211.6 | In-house | 6-250 (250) | alignment | ||
Range on Protein: 472-718
Range on HMM: 6-250/250.0
LPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDKSCAQYWPNKDSVQF
|.| .|||. ....... | | .. .||||||||... ... |.||| ||..|. | |||| . | .||||..| ..| . |||| . . ..
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaeky
GPLKVSIISAETiRSDYVMRKFEIKGPKKG-TLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTsQASGPIVLHCINGIGRSGVFAAIYSAAEKM
| ..||. | |. .||..||. . || .|.|.. . | .. |. .|.|.. | . ..|....| .|.|||| | ||.. |..
Gdvtvsllskee.fadytkrklklskakkaderivrqlhfvvWP.dkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavlerl
ITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEYAN
.. ||.|. .|.||..|| ..|| .||. .|| . .... ...||.
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
|
|||||||||
| subfamily_PTPRK_pd | Subfamily PTPRK | 472-708 | 9.1e-61 | 200.4 | In-house | 40-275 (314) | alignment | ||
Range on Protein: 472-708
Range on HMM: 40-275/314.0
LPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNKDSVq
| .|||. ..|.... |. |.| . |.|||||...... . |..|| ||..|. | ||.| | .. ||||.|| . | .|||.. .|
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.
FGPLKVSIISAETiRSDYVMRKFEIKG---PKKGTLTVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRTsqASGPIVLHCINGIGRSGVFAAIYSAA
.|..|| ....|. ...|.| | .. ..... .|.||| .|| . | | .|.|| | . |.||.|| .| ||.|.| || .
ygdikvelvetel.laelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivl
EKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAE
. . ... ||.|. || ||.... |.| .|| .|. . |
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
|
|||||||||
| subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 472-710 | 1e-19 | 65.6 | In-house | 32-270 (285) | alignment | ||
Range on Protein: 472-710
Range on HMM: 32-270/285.0
LPANIDKNRFPNVLPMEKNRPCLVTKgeagSTDYINASFLNTFIKK-DVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNK--D
|| | ||. .| .|. | | . ||| ||.. | ...|| ||| | |.|.|. . . ..|| | . . || |.|.| .
yeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge
SVQFGPLKVSIISA--ETIrSDYVMRKFEIK---GPKKGTLTVKQFQLMgWDGNQKRPASLAPILHLVDAVSECvrtSQASGPIVLHCINGIGRSGVFAA
|.|| .... . |.| . .. . . | ... |. | .| | |.. | | . ||..|| |.||. |
vvkfgkyeitlteckeeai.agtilnaltvintedasseplymnhvqvp.wwpdqlapedarpmielykwvkkv...npkekpicvhcsagvgrtatfvg
IYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
| |. ... . ..... |. .|| | ..| |. . | . ||.
idyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
|
|||||||||
| subfamily_CG42327_pd | Subfamily CG42327 | 472-569 | 3.8e-16 | 53.7 | In-house | 25-124 (319) | alignment | ||
Range on Protein: 472-569
Range on HMM: 25-124/319.0
LPANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKK-DVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNKDSV
.. ||.|. ||.|. . |. | .|. .. |..||.. . . ..|.|..| .. | ||.| . .| ||| | .| . | ||.|.| |..
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl
|
|||||||||
| subfamily_Cele-PTP-12_pd | Subfamily Cele-PTP-12 | 472-553 | 8.6e-08 | 26.0 | In-house | 31-111 (332) | alignment | ||
Range on Protein: 472-553
Range on HMM: 31-111/332.0
LPANIDKNRFPNVLPMEKNRPCLVTKgeAGSTDYINASFLNTFIKKDVFLATQMPLP-HTTGDIWRMVCDWRSPVIVMLNELD
. |.| || | . ....| | . | |. |||... . || .. .| |. || .|||| . . .|... ..|
flnnmdmnriphlycfdhsrvelapq..dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdid
|
|||||||||
| subfamily_eak_pd | Subfamily eak | 473-614 | 4.7e-10 | 33.4 | In-house | 50-190 (332) | alignment | ||
Range on Protein: 473-614
Range on HMM: 50-190/332.0
PANIDKNrFPNVLPMEKNRPCLvTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVML-NELDLQDKSCAQYWPNKD--SV
....| ...| ... | | ||||| .. .. | .. |.|| . .|| ||.| ....|. . .|.|.| .
leavnrn.vvkivpydrylvrl.tssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel
QFGPLKVSIISAeTIRSDYVMRKFEIKGPkKGTLTVKQFQLMGWD
.|| |.| . |. . .|..|.. | |. ... ||
kfGildverkef.vkrniletrllelskG.nethrvlhykvfGwt
|
|||||||||
| subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 474-711 | 1.6e-60 | 199.7 | In-house | 50-285 (297) | alignment | ||
Range on Protein: 474-711
Range on HMM: 50-285/297.0
ANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKkdVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDKSCAQYWPNKDSVQFGP
|..|.|. |.||....| | .. . ||.||||.... . ...|||| . | | |.|| | . .|||||... .||.||.||..| ...||
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGd
LKVSIISAETiRSDYVMRKFEIKGPK-KGTLTVKQFQLMGWDGNQ-KRPASLAPILHLVDAVSECVRTsQASGPIVLHCINGIGRSGVFAAIYSAAEKMI
. | . | . |. .. |..|.. | | . |||.| . | .. .| | . .|.|.. | . . .|.||...||..|.|| ||. .| | ..
vsvvllsvse.reGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsq.naegPllvhclaGvGrtgvlltidsvvaeak
TDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
. .||||. ||.|| .|| .. .||. |. . |..
rekevdifglvkklrqerpylvqtkeqykfvyvavleall
|
|||||||||
| subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 474-711 | 7.4e-57 | 187.6 | In-house | 42-277 (515) | alignment | ||
Range on Protein: 474-711
Range on HMM: 42-277/515.0
ANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDKS-CAQYWPN--KDSVQ
| |||. |.||....| | .. ||.|||....| ..|.|.|.. .. | ||.| . . |.|...| .||. |..|||. |||.
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk
FGPLKVSIISAETIrSDYVMRKFEIKGPKKgTLTVKQFQLMGWDGNQKrPASLAPILHLVDAVSEcvRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKM
|| .||...| |. .. . ||... .. . || ||.. .| . | .| |. .| ..| . |...|| |.|| ||. .| | ..
fGsikvelvsleac.tggikrkltvlkgdd.srtvtqfhfteWPdkGv.pkhtssllklikevka..dhgqythpliihcsaGvGrtGvvisidsvvaha
ITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
| .||.|. |. .|..|| .. .||. |. . |...
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
|
|||||||||
| subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 474-708 | 8.3e-50 | 164.5 | In-house | 48-277 (315) | alignment | ||
Range on Protein: 474-708
Range on HMM: 48-277/315.0
ANIDKNRFPNVLPMEKNRPCL-VTKGEaGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDKSCAQ-YWPNKdSVQF
| .|||. |.....| |. | ... . .||.||.|.. . ||. ..|.| |.. . .| ||.| . ||||..| ..|. |. |||.| | .
enkqknryiniiaydksrvqlpllend.phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviy
GPLKVSIISAEtIRSDYVMRKFEIKGpKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQasGPIVLHCINGIGRSGVFAAIYSAAEKMI
|.. |. .| | . ..| .| . . .. .| |... | . . |.. |...|. | .| |.||.|| .|.||.| | .. . ...
Gkitvtrksee.vnteytvrtlsvvf.gdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqae
TDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAE
.. .|... ....|.|| |.....|| |. . |
aenaidvynfitgvrqnrikmvqvaeqyqfiydalle
|
|||||||||
| subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 474-718 | 9.8e-40 | 131.1 | In-house | 39-301 (301) | alignment | ||
Range on Protein: 474-718
Range on HMM: 39-301/301.0
ANIDKNRFPNVLPMEKNRPCLVTKGE--AGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQ-DKSCAQYWPN--KDS
.| ||| |. ....|| | .| . ...|||||... . .| | |.| |. .| |.||.. . . |||. .|. . ..| ||||| ..|
enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaes
VQFGPLKVSIISAE-----TIR-----------SDYVMRKFEIKGPKkGTLTVKQFQLMGW--DGNQKRPASlapILHLVDAVSECvRTSQASGPIVLHC
.|||..| ... .|| |..|||..| | . .| |.|. | || . |. .|. .| | . . ||.| ||
eefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprt...vLqviddvihr.qqkigggpvvVHC
INGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKFDEYAN
....||||. .. . | . ||.|| .|..| ..| .. .||. |. . .|.. . |||
SdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
|
|||||||||
| subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 474-702 | 5.7e-31 | 102.5 | In-house | 7-233 (239) | alignment | ||
Range on Protein: 474-702
Range on HMM: 7-233/239.0
ANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIK-KDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNKDSvQF
| |||. |.. ...| | . .||||||.| . ..||| . ..||.|||. . | ||||| | . . | | ||||. | ..
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky
GPLKVSIISAETIrSDYVMRKFEIKGP-KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGRSGVFAAIYSAAEKM
|.|.. .| . .||..| | . . | |... | .. | . .| | ... . . | |.|| |.||.| | | . .
cnlrvtlrktevf.adyiirtfvmsqvgqteeryvyqyhftvwp.dkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlrqa
ITDSSVDIFQSVKRLRANRPSMIESVDQYSIC
. .||||. || .| .|| |... .|| .
kkqktvdifnyvkairedrphmvqtseqyvfi
|
|||||||||
| subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 474-702 | 6.9e-31 | 102.2 | In-house | 6-232 (239) | alignment | ||
Range on Protein: 474-702
Range on HMM: 6-232/239.0
ANIDKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFIK-KDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNKDSvQF
| |||. |.. ...| | . .||||||.| . ..||| . ..||.|||. . | ||||| | . . | | ||||. | ..
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky
GPLKVSIISAETIrSDYVMRKFEIKGP-KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGRSGVFAAIYSAAEKM
|.|.. .| . .||..| | . . | |... | .. | . .| | ... . . | |.|| |.||.| | | . .
cnlrvtlrktevf.adyiirtfvmsqvgqteeryvyqyhftvwp.dkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlrqa
ITDSSVDIFQSVKRLRANRPSMIESVDQYSIC
. .||||. || .| .|| |... .|| .
kkqktvdifnyvkairedrphmvqtseqyvfi
|
|||||||||
| subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 474-576 | 1.9e-12 | 41.3 | In-house | 51-154 (310) | alignment | ||
Range on Protein: 474-576
Range on HMM: 51-154/310.0
ANIDKNRFPNVLPMEKNRPCLvTKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKDSV-QF
.. |||. .|. ... | | . . ||| | ...| .. |. .| || || |.|||. . |. |..| . . | ||| .
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety
GPLKV
| ..|
gcirv
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 475-707 | 6.4e-65 | 214.2 | Pfam-A | 1-234 (235) | alignment | ||
Range on Protein: 475-707
Range on HMM: 1-234/235.0
NIDKNRFPNVLPMEKNRPCLvtKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDL-QDKSCAQYWP--NKDSVQF
| .|||....||..|.| | ||. |..|||||...... .| |.|||.||..| .| |||| . .. |||||..|. ... |||||| ...|...
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty
GPLKVSII-SAETIRSDYVMRKFEIKGPKKGT--LTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVrtSQASGPIVLHCINGIGRSGVFAAIYSAAE
| .|| . . ... ..|..||.|.| |. . .|||... .| ... |.| ..|.|...| . .. |||.| ||..|.||.|.|.|. . |
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille
KMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMA
.. ....||..| ||.||..||.|..|..|| .|. ..
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 475-707 | 6.4e-65 | 214.2 | In-house | 1-234 (235) | alignment | ||
Range on Protein: 475-707
Range on HMM: 1-234/235.0
NIDKNRFPNVLPMEKNRPCLvtKGEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDL-QDKSCAQYWP--NKDSVQF
| .|||....||..|.| | ||. |..|||||...... .| |.|||.||..| .| |||| . .. |||||..|. ... |||||| ...|...
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty
GPLKVSII-SAETIRSDYVMRKFEIKGPKKGT--LTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVrtSQASGPIVLHCINGIGRSGVFAAIYSAAE
| .|| . . ... ..|..||.|.| |. . .|||... .| ... |.| ..|.|...| . .. |||.| ||..|.||.|.|.|. . |
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille
KMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMA
.. ....||..| ||.||..||.|..|..|| .|. ..
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
| 0041856 | (Phosphotyrosine protein) phosphatases II | 475-711 | 2.5e-38 | 126.8 | In-house | 1-172 (182) | alignment | ||
Range on Protein: 475-711
Range on HMM: 1-172/182.0
NIDKNRFPNVLPMEKNRpclvtkgeagSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNeldlqdksCAQYWPnkdsvqfgpl
|.||||....||.. .| |||||... . . |.||| ||..|. | .||. ... .||.|. . .|||
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..........
kvsiisaetirsdyvmrkfeikgpKKGTLTVKQFQLMGWDGNQKRPasLAPILHLVDAVSEcvrtsqASGPIVLHCINGIGRSGVFAAIYsaaekMITDS
.. . .. |.. ..|... . | .|.....| | .||.. || |.||.|...|.| ..
........................ellerlgiqylylpwpDhgvpd..ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay.....lmkkl
SVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
.|.... || .| || |... .|| ... . |...
gvsleeavklvrsrRpgmvitpnqyfflqlallelll
|
|||||||||
| subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 475-704 | 2.3e-34 | 113.7 | In-house | 3-233 (237) | alignment | ||
Range on Protein: 475-704
Range on HMM: 3-233/237.0
NIDKNRFPNVLPMEKNRpcLVTKGEAGSTDYINASFLNTFIK-KDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNKDS-VQF
| |||. |. ....| .| || ...|||||..|. | ..|.| || . |.|.|| . . ||||| | . ... | .|||. | .
nkiknrygnivaydhsr..vvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay
GPLKVSIISAETIrSDYVMRKFEI--KGPKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEK
| | ||. | . ||| .| . . .. .|. ..|.|. | .. | | .| . . . . . ||| ..|| |.||.|.| | . .
gvltvslkkkeef.sdytvrslllskrltlkevrlihqyqftswp.drgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq
MITDSSVDIFQSVKRLRANRPSMIESVDQYSICYE
|||.. |. . .|| .|.. ||| . ..
akekkvvdiynyvysieedrpyiiqtkdqyvfihq
|
|||||||||
| subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 477-712 | 1.1e-38 | 127.8 | In-house | 22-266 (270) | alignment | ||
Range on Protein: 477-712
Range on HMM: 22-266/270.0
DKNRFPNVLPMEKNRPCLVTKGEAGSTDYINASFLNTFI-KKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWPNKDSV----Q
||. ..|| . | .| . | | |||| ... | .| ..|.. ||| |. . |||. . ... |||. .| . . |..|||.. .
klnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkle
FGPLKVSIISaETIRSDYVMRKFEIKgPKKGTLTVKQFQLMGWD--GNQKRPA---SLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYS
.| .|| .| |. .. |.... ... | . . |. | | ... | .|... || . . . ..|.. || .|.||.|.. |.
dgkikvlals.eekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDi
AAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
| . . ....||. . ...|| .|. ... ..|| |....||...
avrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
|
|||||||||
| subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 477-699 | 5e-25 | 82.9 | In-house | 52-270 (301) | alignment | ||
Range on Protein: 477-699
Range on HMM: 52-270/301.0
DKNRFPNVlPMEKNRPCLVTkgEAGSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLN-ELDLQDKSCAQYWPNK--DSVQFGP
||.|.|.| | . . | . | | | ...| . . |.||| ||. |. | | |. . |||| ... . . |..| | | .... |
dkhryptv.PckPstavevi..vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr
LKVSIISAETIRSDYVM-RKFEIKGP--KKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVsecvRTSqaSGPIVLHCINGIGRSGVFAAIYSAAEKM
|. | . |.| .. .. |..|.. | | || .| . | .. | | | . .|.. | . | |||.|| .||||| | . | ..
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewt.drgvPkshaelfdlmelv....kks..ekPivvhcsaGiGrsvafigteylarev
ITDSSVDIFQSVKRLRANRPSMIESVDQY
.| ... ...|.|| .| . . . |
eadptieltealkhlrehrwngvqtnsql
|
|||||||||
| subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 477-567 | 6e-15 | 49.8 | In-house | 49-154 (350) | alignment | ||
Range on Protein: 477-567
Range on HMM: 49-154/350.0
DKNRFPNVLPMEKNRPCLV--------TKGEAGSTDYINASFLNTF-----IKKDV-FLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELD-LQDKSCAQ
|||. |.|| |..| | | . |||||..|. |. | ..||| ||| | | .... .||..|.... |. . | .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr
YWPNKD
||.. .
YWqegs
|
|||||||||
| subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 477-711 | 2.5e-10 | 34.5 | In-house | 45-277 (312) | alignment | ||
Range on Protein: 477-711
Range on HMM: 45-277/312.0
DKNRFPNVLPMEKNRPCLVTKgeagSTDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWpnKDSVQFGPLK
| ||.||. .. | | || | |.. | . |..|| || |. .|... | |..| . . . ||.| | | | |.
dlnrypniqcwdrgrftlagd....enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi..sdivgfvdle
VSIISAETIRsdyvmrKFEIKGPKKGTL----------------TVKQFQLMGWDgNQKRPASLAPILHLVDAVSecvrtsQASGPIVLHCINGIGRSGV
. .| . || | | . ....| | .. | | | |. || . |.. || |.||.|
dhrvyteyct......eieiggkskdkithrvlkvvvkatgqesklnhyqwaswp.dhgmpdscdtalrllsavk......kdkkpviahcsagvgrtgt
FAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
.| | | . .. .| || .| .. . || . . |..
laliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
|
|||||||||
| subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 479-707 | 1.4e-19 | 65.3 | In-house | 23-256 (290) | alignment | ||
Range on Protein: 479-707
Range on HMM: 23-256/290.0
NRFPNVLpMEKNRPCLVTKGEAGSTDYINASFLnTFIKKDVFLATQMPLPHT-------TGDIWRMVCDWRSPVIVMLNELDLQDKS-----CAQYWPNK
.| .. | .|..| | |. . ||| |... |. . ...|| |. .. . | |. . .. .||| | . ... ||.| |..
qRlevpL.veatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes
D--SVQFGPLKVSIiSAETIRSDYVMRKFEIKGPKKGTLTVKQFQLMGWDGNQKRPASlAPILHLVDAVSeCVRTsqasgPIVLHCINGIGRSGVFAAIY
...|. |.|. | .|. ..| .. .||. .| ||. . .. . .|.|.. | . .| |...||..|| || ..|||
vgeelkfkgltvkC.kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedt.ktllsliqkvk.askt.....pvivHcvdGiSrsAalaaii
SAAEKMI-TDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMA
. |.. | .|| . . .| || .| .| | ... |.
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
|
|||||||||
| 0044763 | (Phosphotyrosine protein) phosphatases II | 486-704 | 5.1e-21 | 70.5 | In-house | 1-165 (178) | alignment | ||
Range on Protein: 486-704
Range on HMM: 1-165/178.0
PMEKNRPCLVTKGEAGSTDYINASFLNTFikkdVFLATQMPlphttGDIWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNKDSvqfgplkvsiisaeti
|.. .| .| . ..||||||. . ..|... | | ....... .||.|.| . .| .||| . .
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................
rsdyvmrkfeikgpkkgtltvKQFQLMGWDGNQKRPaSLAPILHLVDAVSECVRtsQASGPIVLHCINGIGRSGVFAAIYSAAEKmitdsSVDIFQSVKR
|.. ...... . .|. .| .|... |.. . ||.. || |.||||...|.| . ...... ...
.....................iqylhipipDhgvpd.llehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel
LRANRPsMIESVDQYSICYE
.|. || .... .|. .||
vrerRp.ivpnpgqlrqLye
|
|||||||||
| 0046846 | (Phosphotyrosine protein) phosphatases II | 498-711 | 1.9e-30 | 101.3 | In-house | 7-174 (176) | alignment | ||
Range on Protein: 498-711
Range on HMM: 7-174/176.0
GEAGSTDYINASFLNTFikkdVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNKDSVQFgplkvsiisaetirsdyvmrkfeik
|. .. |||||... . ..||| |||.|. | ..|. ... ..|.|.|. .|. .|..||| ....
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................
gpkkgtltvkQFQLMGWDGNQKRPAslAPILHLVDAVSECVRTSqasGPIVLHCINGIGRSGVFAAIYsaaeKMITDSSVDIFQSVKRLRANRP-SMIES
|.. ..|. .. . . .|.|.... |... ||.. || ||||.|...|.| .... ..... ....|. || ....
..........qylhlpwpDhgvpdl..elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt
VDQYSICYEGMAEYMK
.|| .|| . ...|
peQyrflyefellllk
|
|||||||||
| 0043147 | (Phosphotyrosine protein) phosphatases II | 502-703 | 1e-30 | 102.1 | In-house | 4-154 (172) | alignment | ||
Range on Protein: 502-703
Range on HMM: 4-154/172.0
STDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELdlqdkscaqywpnkdsvqfgplkvsiisaetirsdyvmrkfeIKGPKKG
..||||||.|.. .. | |.||| ||..|. | |||. .. .||.|.|| . |..
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpell
TLTVKQFQLMGWDGNQKRpaSLAPILHLVDAVSECVrTSQASGPIVLHCINGIGRSGVFAAIYSAAekmitdSSVDIFQSVKRLRANRPSMIESVDQYSI
. .. |.. ..|. . .|. .|.... . | . . .||.. || |.||.|...|.| ...... |. .|. || .... .||
erlgiqylylpwpDhgvp..llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf
CY
.|
ly
|
|||||||||
| subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 502-710 | 1.3e-16 | 55.5 | In-house | 66-271 (288) | alignment | ||
Range on Protein: 502-710
Range on HMM: 66-271/288.0
STDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNK--DSVQFGPLK-VSIISAETIRSDYVMRKFEIKG
. ||.| . . | .. .| || | . .|.|. . ||||.|| .. . |.|.| | .....| | | . . | .. . |.
pdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllrisk
PKKGTLTVKQFQLMGWDgNQKRPASLAPILHLVDAVsecvrtSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVD
. . . ||. | || .. | . . |.|.. . . |||.|. .|.||.| .. | |.| . | . | . ...||..| |..
egeekvivkilhlleWd.ddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtem
QYSICYEGMAEYM
|| . . |..
qylyvhrcvleel
|
|||||||||
| subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 502-566 | 1.9e-07 | 24.8 | In-house | 89-156 (349) | alignment | ||
Range on Protein: 502-566
Range on HMM: 89-156/349.0
STDYINASFLN--TFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELD-LQDKSCAQYWPNK
||||| .|. . . ..|||.||| | | .... . .... ||. . |. . | .|| .
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
|
|||||||||
| 0036282 | (Phosphotyrosine protein) phosphatases II | 503-704 | 2.9e-33 | 110.4 | In-house | 2-164 (174) | alignment | ||
Range on Protein: 503-704
Range on HMM: 2-164/174.0
TDYINASFLNTFIKKDVFLATQMPLPhttgdIWRMVCDWRSPVIVMLNELDLQD-KSCAQYWPNkdsvqfgplkvsiisaetirsdyvmrkfeikGPKKG
.||||||.|. .. . ..|.| ||. |.|...... ..|||.|. . | .||| ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl
TLTVKQFQLMGWDGNQKRPASLapILHLVDAVSECVRTsQASGPIVLHCINGIGRSGVFAAIYSAAEKMItDSSVDIFQSVKRLRANRPSMIESVDQYSI
. .. |.. ..|.... . | .|..|..| |.. .||.. || |.||.|...|.| .. | ||... |..|| || |... .||
erlgiqylylpwpDhgvpdlsi..llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf
CYE
.|.
lyy
|
|||||||||
| 0051429 | (Phosphotyrosine protein) phosphatases II | 503-713 | 5.1e-33 | 110.3 | In-house | 4-228 (272) | alignment | ||
Range on Protein: 503-713
Range on HMM: 4-228/272.0
TDYINASFLNTF---IKKDVFLATQMPLPHTTGDIWRMvCDWRSPVIVMLNELDLQD-KSCAQYWPNKDSVQFGPLKVSIISA-----------ETIRSD
..||||...... .|.........|||.| |.||. .... .||.| ... .. | .|||. . ... | | . |.. .|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld
YVMRKFEIK---GPKKGtLTVKQFQLMGWDGNQKRPASLAPILHLVDAvsecvrtsqaSGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVD-------
|..|..... ..... ..| ... ..| . .| .|.|. . .||.. || |..|.|...|.. .. . . ||
yilrellltlllsagea.revmhlhytdwpdhgvpqeallellellld..........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl
-IFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKKF
... |..||| || .... .|| .|| ..|.....
yleeaveelraqrpgavqteeqylflyeallellrsl
|
|||||||||
| 0051082 | (Phosphotyrosine protein) phosphatases II | 503-704 | 1.9e-24 | 81.4 | In-house | 3-147 (151) | alignment | ||
Range on Protein: 503-704
Range on HMM: 3-147/151.0
TDYINASFLNTFikkdvFLATQMPLPhttgDIWRMVCDWRSPVIVMLNELDLQDkSCAQYWPNKDsvqfgplkvsiisaetirsdyvmrkfeikgpkkgt
.||||.|.. . ......||. | .... .. .||.|.... . |..|.|. .
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................
LTVKQFQLMGWDGNqKRPASLAPILHLVDAVSEcvrtsQASGPIVLHCINGIGRSGVFAAIYSAAEKmitdssVDIFQSVKRLRANRPSMIESVDQYSIC
..|.......|. . | |.. .|...... . . .||.. || |.||.|...|.| ... |.... .. .|. || .. . .|. ..
ievlhipildwpdp.glplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq
YE
.
lf
|
|||||||||
| subfamily_Sponge-PTP-4_pd | Subfamily Sponge-PTP-4 | 503-590 | 2.8e-07 | 24.9 | In-house | 13-96 (130) | alignment | ||
Range on Protein: 503-590
Range on HMM: 13-96/130.0
TDYINASFLNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDkscaQYWPNKDSVQFGPLKVSIISAETIRSDYVM
.||||||. . .| || || |. |.|.|. . |.|.| .. .| .|||. . ... .. . ... ....
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefknik
|
|||||||||
| 0049260 | (Phosphotyrosine protein) phosphatases II | 511-703 | 2.5e-25 | 84.3 | In-house | 2-143 (152) | alignment | ||
Range on Protein: 511-703
Range on HMM: 2-143/152.0
LNTFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELDLQDK-SCAQYWpnkdsvqfgplkvsiisaetirsdyvmrkfeikgpkkgtltvkQFQ
.. . .. |.||| |.|.|. | |||. .. .||||.||. .| |.||. |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl
LMGWDGNQkRPASLAPILHLVDAVSECvrTSQASGPIVLHCINGIGRSGVFAAIYSAAekmitdSSVDIFQSVKRLRANRPSMIESVDQYSICY
. |. . | . .| |.... .. . .||.. || |.||.|...|.| |.... |...|. || .... .|. .|
hlpwpDhg.vpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
|
|||||||||
| subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 513-705 | 2.2e-35 | 116.8 | In-house | 231-433 (440) | alignment | ||
Range on Protein: 513-705
Range on HMM: 231-433/440.0
TFIKKDVFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNELdlQDKSCAQYWP-NKDSVQFGPLKVSIISAETIRSdYVMRKFEIKGpKKGTLTVKQFQLM
. ||. |.|||||| | |.||.| |.| |.|||.| .||.|. ||| | || |||. | .| . .| .|.| |. ..||..
gyskknafiatqmpldstvldfwrlvhdyristiimlnql..ndktcsiywpvntrsvtfgpftvghkgsenmnr.vkvrtlelky.keevheirqfevq
GW------DGNQKRPASLAPILHLVDAVSECV--RTSQAS-----GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQ
| || | . . .| |.| . | |... | ||..||. || |||| .. |.. | ..|.|| .. || || .. .. .
twptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltd
YSICYEG
| .||
yllcykl
|
|||||||||
| subfamily_Nvec-PTP-3_pd | Subfamily Nvec-PTP-3 | 519-704 | 1.1e-17 | 58.8 | In-house | 5-197 (198) | alignment | ||
Range on Protein: 519-704
Range on HMM: 5-197/198.0
VFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNElDLQDKS--CAQYWPNKDSV--QFGPLKVSIiSAETIRSDYVMRKFEIKG---PKKGTLTVKQFQLM
..||| || .| |.|.|| . | |||.|. | ..| . ||| .| ..| | |. . | ..||.. . . | . ..|.
ryiatqhplretladfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvtt.ktittkpdytitaliltnnttappstreishyqft
GWDgnQKRPASLAPILHLVDAVSECVRTS--QASGPIVLHCINGIGRSGVFAAIYS--AAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYE
| .| .| .. .| | | . . |...|| .| | .||| |. . . | ||.|. |||| | .| |...| . |.
swk..ekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
|
|||||||||
| subfamily_Anemone-PTP-3_pd | Subfamily Anemone-PTP-3 | 519-704 | 1.2e-17 | 58.8 | In-house | 6-198 (199) | alignment | ||
Range on Protein: 519-704
Range on HMM: 6-198/199.0
VFLATQMPLPHTTGDIWRMVCDWRSPVIVMLNElDLQDKS--CAQYWPNKDSV--QFGPLKVSIiSAETIRSDYVMRKFEIKG---PKKGTLTVKQFQLM
..||| || .| |.|.|| . | |||.|. | ..| . ||| .| ..| | |. . | ..||.. . . | . ..|.
ryiatqhplretmadfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvtt.ktittkpdytitaliltnnttappstreishyqft
GWDgnQKRPASLAPILHLVDAVSECVRTS--QASGPIVLHCINGIGRSGVFAAIYS--AAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYE
| .| .| .. .| | | . . |...|| .| | .||| |. . . | ||.|. |||| | .| |...| . |.
swk..ekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
|
|||||||||
| subfamily_Cele-PTP-7_pd | Subfamily Cele-PTP-7 | 521-696 | 8.3e-07 | 22.7 | In-house | 94-274 (302) | alignment | ||
Range on Protein: 521-696
Range on HMM: 94-274/302.0
LATQMPLPHTTGDIWRMVCDWRSPVIVMLNEL-DLQDKSCAQYWPNK--DSVQFGPLKVSIISAETI------RSDYVMRKFEIKGPKKG---TLTVKQF
.| |. | .. ... ..| | .. . ..| ||.|. .| . ..|| | .| .| . .... . ||| || ||. .
kkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdil
QLMGWDgNQKRPASLAPILHLVDaVSECVRTSqasgpIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESV
. .| . |. . |... |. ... ...|| .|.||.| . || . .. |. . |. .|. | . .
afsawp.dhGapkeaytaldilk.fcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqde
|
|||||||||
| subfamily_Cele-PTP-9_pd | Subfamily Cele-PTP-9 | 530-693 | 2e-13 | 45.0 | In-house | 40-204 (255) | alignment | ||
Range on Protein: 530-693
Range on HMM: 40-204/255.0
TTGDIWRMVCDWRSPVIVMLNELDL-QDKSCAQYWPNKDSVQFGPLKVSIISAEtIRSDYVMRKFEIK---GPKKGTLTVKQFQLMGWDgNQKRPASLAP
| .... .. |.||| .. . . | .|.| . . .|...... .| |.| || | || | ||| .. || ... |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWi.eknaPelare
ILHLVDAVsecvrtsQASGPIVLHCINGIGRSGVFAAIYSAAEKMITD----SS--VDIFQSVKRLRANRPSMI
||... .| . | ..|.|| .||||| |. . .. ||| . .| . .. || .|.. |
ilnilkvv.......rdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkrai
|
|||||||||
| subfamily_hpo-7_pd | Subfamily hpo-7 | 532-691 | 1.1e-11 | 39.2 | In-house | 48-208 (263) | alignment | ||
Range on Protein: 532-691
Range on HMM: 48-208/263.0
GDIWRMVCDWRSPVIVMLNELDLQ-DKSCAQYWPNKDSVQFGPLKVSIISAETIRsDYVMRKFEIKG---PKKGTLTVKQFQLMGWDgNQKRPASLAPIL
..... .. |.||| . . . | .|.| . . .|.. ..... | ... |. || | |||... || ... | ||
dkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWi.ekndpelareil
HLVDAVsecvRTsqaSGPIVLHCINGIGRSGVFAAIYSAAEKMITD----SS--VDIFQSVKRLRANRPS
...... | | ..| || .||||| |. . .. ||| | .| . .. || .|..
nilkva....rn...skslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkr
|
|||||||||
| subfamily_Cele-PTP-12_pd | Subfamily Cele-PTP-12 | 549-706 | 3.1e-07 | 24.2 | In-house | 140-298 (332) | alignment | ||
Range on Protein: 549-706
Range on HMM: 140-298/332.0
LNELDLQDKSCAQYWPNKDSVQFGPlKVSiISAETIRSDYVMRKFEIKGP-KKGTLTVKQFQLMGWDGNQKRPASLAPILHLV--DAVSECVRTSQASGP
|.| .|. | | ..||.| | . | .| | | .|. |. |.. || ... | | | . . . . . .| . ||
leecelkakicrkfwpekrskkdfp.als.iqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigp
IVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGM
|.| | |. . ..|.| .. . | . ... .. .| . .| || . | .
imlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystaceml
|
|||||||||
| subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 599-711 | 1.8e-17 | 57.9 | In-house | 274-386 (392) | alignment | ||
Range on Protein: 599-711
Range on HMM: 274-386/392.0
KKGTLTVKQFQLMGWD--GNQKRPASlAPILHLVDAVSECVRtSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESV
| . || |.|. || | .... . .|.|. || |. |..||. | ||.||| . .. ||||||.|| |||.| ....
lkashtvtqyqfhgwpkhgsdqqsga.rsllkliravkgstn.skkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqte
DQYSICYEGMAEYMK
..|.. |. . ||..
eeyafvydvireylh
|
|||||||||
| 0048076 | (Phosphotyrosine protein) phosphatases II | 602-704 | 4.2e-15 | 51.2 | In-house | 44-137 (145) | alignment | ||
Range on Protein: 602-704
Range on HMM: 44-137/145.0
TLTVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRTSqasGPIVLHCINGIGRSGVFAAIYSAAEkmitdSSVDIFQSVKRLRANRPSMIESVDQYSI
. .. |.. ..|... | .|. .|...... |... ||.. || |.||.|...|.| . .|.... ....|. || ......|.
erlgiqylylpwpDh.gvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf
CYE
.||
lye
|
|||||||||
| subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 602-710 | 7.7e-10 | 33.0 | In-house | 214-344 (350) | alignment | ||
Range on Protein: 602-710
Range on HMM: 214-344/350.0
TLTVKQFQLMGWDGN--QKRPASLAPILH----LVD-AVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAE-----KMITDSSVD----------IF
. | |.|. | .| |. ..| |.| ..| .. | ||. || |.|| |.. .. | . ...|. |. |.
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis
QSVKRLRANRPSMIESVDQYSICYEGMAEYM
. |..|| | ||. ..||. ..|| . |
iivnelrkqrismvqnldqfifiYeallfyf
|
|||||||||
| PTPc_DSPc_SM00012 | 604-707 | 2.2e-25 | 84.2 | In-house | 1-104 (105) | alignment | |||
Range on Protein: 604-707
Range on HMM: 1-104/105.0
TVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITD-SSVDIFQSVKRLRANRPSMIESVDQYSIC
|||... .|| . | . .||.|..|| .. . |. |.|.|.|| .|.||.|.|.|.. . ... . ..||||| ||.|| ||.|... .||...
tvkhyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl
YEGMA
|. ..
yrall
|
|||||||||
| 0048179 | (Phosphotyrosine protein) phosphatases II | 604-704 | 2.7e-15 | 51.8 | In-house | 48-139 (144) | alignment | ||
Range on Protein: 604-704
Range on HMM: 48-139/144.0
TVKQFQLMGWDGNqKRPASLAPILHLVDAVSECVRtsqASGPIVLHCINGIGRSGVFAAIYsaaekMITDSSVDIFQSVKRLRANRPSMIESVDQYSICY
.. |.. ..|... | .|. .|...... |... .||.. || |.||.|...|.| .. ..... ....|. || .... .|. ..
egiqylhlpwpDh.gvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay.....lmkklglsleealalvrsrrpgavpnpgqlrfLl
E
|
e
|
|||||||||
| subfamily_PTPDC1_pd | Subfamily PTPDC1 | 621-704 | 5.4e-06 | 21.0 | In-house | 96-170 (182) | alignment | ||
Range on Protein: 621-704
Range on HMM: 96-170/182.0
ASLAPILHLVDAVSECVRtsqaSGPIVLHCINGIGRSGVFAAIYsaaekMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYE
||| || .| |. ... | . .|| | || || | | .. .... ...| .|..||. |.. .| .. |
asleriLdivkvvafalq....egkvavhChaGlGrtGvliacy.....lvyakrltaekaiklvrskrpksiqtreqvelvke
|
|||||||||
| 0038934 | (Phosphotyrosine protein) phosphatases II | 622-709 | 1.6e-08 | 29.9 | In-house | 95-176 (194) | alignment | ||
Range on Protein: 622-709
Range on HMM: 95-176/194.0
SLAPILHLVDAVSECVRTsQASGPIVLHCINGIGRSGVFAAIYsaaekMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEY
||. .|. .|.| | .. ...| .. || |.||.|...| | .| . ......| ||..|...|.... .. . |.
sleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaY.....LiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
|
|||||||||
| PTEN_1 | 622-698 | 4.7e-06 | 21.5 | In-house | 109-183 (196) | alignment | |||
Range on Protein: 622-698
Range on HMM: 109-183/196.0
SLAPILHLVDAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMitDSSVDIFQSVKRLR-ANRPSmIESVDQ
||. ... .. . |... . . .. || |.||||. .| | . . .. . .. |.. | ...| . | .
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk..ltadeAlelvrekRppgapn.spsqer
|
|||||||||
| subfamily_CG42327_pd | Subfamily CG42327 | 631-712 | 3.8e-13 | 43.8 | In-house | 235-317 (319) | alignment | ||
Range on Protein: 631-712
Range on HMM: 235-317/319.0
DAVSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAEKMITD-SSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMKK
.| | . ||.|.|| .|.||.|. | | ... . |||| | | .| .| | . ...|| | . || ||
gnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk
|
|||||||||
| subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 633-710 | 3.5e-06 | 20.6 | In-house | 255-344 (349) | alignment | ||
Range on Protein: 633-710
Range on HMM: 255-344/349.0
VSECVRTSQASGPIVLHCINGIGRSGVFAAIYSAAE--KMITDSSVD----------IFQSVKRLRANRPSMIESVDQYSICYEGMAEYM
.. .. . ....|| | ||.||. . . . .. .. |. |. .| || | ||.. . |. ..|| . .|.
farlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
|
|||||||||
| subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 644-706 | 6.3e-08 | 26.8 | In-house | 229-291 (297) | alignment | ||
Range on Protein: 644-706
Range on HMM: 229-291/297.0
GPIVLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGM
....|| |.||||| ..|. . |. .. || .|. ......|. ..|. .
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
|
|||||||||
| subfamily_Sponge-PTP7_pd | Subfamily Sponge-PTP7 | 647-711 | 1.9e-09 | 31.7 | In-house | 1-65 (69) | alignment | ||
Range on Protein: 647-711
Range on HMM: 1-65/69.0
VLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
|.|| | ||.| | || .. .. |||| |. .| || |. ..| .. ..| .|
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
|
|||||||||
| subfamily_Sponge-PTP-7_pd | Subfamily Sponge-PTP-7 | 647-711 | 4.1e-09 | 30.7 | In-house | 2-66 (69) | alignment | ||
Range on Protein: 647-711
Range on HMM: 2-66/69.0
VLHCINGIGRSGVFAAIYSAAEKMITDSSVDIFQSVKRLRANRPSMIESVDQYSICYEGMAEYMK
|.|| | ||.| | || .. .. |||| |. .| || |. .| .. ..| .|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
|
|||||||||