Gene SpurPTP-sf4-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP103_AA protein Get Run
SpurP103_AA_1513-1785 phosphatase_domain Get Run
SpurP103_AA_1797-2080 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 136-215 1.7e-10 34.1 Pfam-A 5-79 (85) alignment 
Range on Protein: 136-215
Range on HMM: 5-79/85.0
NILVQEMTSHSVTIRWTPWNetydRGDGPVIGYRVYYYITHRQAdiARASRDLIRDT-TFTITNLTRDTVYDFRVTATREG
|. | |.||.|.|..|.| .     |.||. ||.| |  .  .   .  .... |.| ..|.|.|. .| | |||.|  ..
nlsvsevtstsltlsWsppk....dgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 338-424 1.9e-11 37.1 Pfam-A 3-84 (85) alignment 
Range on Protein: 338-424
Range on HMM: 3-84/85.0
VGALHMSP-STTQIEISWELSSglcSPDYYIIRYSV-YqkLACQ--SpetipTEFEVNTTSTQ-HTNLMGLEPYSRYKITVTAVNGAGQSEP
.. |..|. ..|....||. ..   ...  | .|.| |    ..  .      . |.....|. . .| ||.|...|...|.||||||....
PenlsvsevtstsltlsWsppk...dgggpitgYevey..rekggge.....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 598-681 8.5e-09 28.6 Pfam-A 9-83 (85) alignment 
Range on Protein: 598-681
Range on HMM: 9-83/85.0
EHSGTSGLTVTWQPPSSPPCRPTQYEIKYyvlqgD-----McednskdriMTSAGTVNGSTFTFNVLELRPNSEYRVLVRGRTSSGYGD
.  ... ||..|.||...    | ||..|                      .   || ..| .... .|.|..||.. |. ..  |.| 
sevtstsltlsWsppkdgggpitgYevey.....rekggge.........ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 697-775 7.3e-11 35.2 Pfam-A 2-77 (85) alignment 
Range on Protein: 697-775
Range on HMM: 2-77/85.0
PPTNIQSASTKKRSIVFTWDKPEcgNRSGPISSYEVMLSNYTGGV-VYYGNVSAGAAsaGYKISDLIPYSNYSIRIRAWN
.|.|..  ..  .|....|..|.  ...|||..||| ... .||      .|.. .    .....| |...|..|..| |
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt..svtltgLkpgteYefrVqavn
TRIC TRIC channel 827-1015 3.4e-70 221.8 Pfam-A 6-194 (197) alignment 
Range on Protein: 827-1015
Range on HMM: 6-194/197.0
GFVSLAENNPLACWLCSMLSCFAGYILSNALLGQSLLAPFAYHSKIGTATIVWYMIFYSPADIFYKLVTSFPGKLVIGPMKEAVRARKVGLGVLQAAQVY
| |.|....||||||..||.||.|.|||. |||..|.||.. ...| .||||||..||.| |..|||.. .| |||.  .||..||.|.  || .||. |
gavelsrksPlacWlsamlvcFggailsslllgepliaplknttnillativWYlvfycPfdlvyklasllPvklvlvalkevkRakkilaGvshaakly

PQGFIIMVIIGTVRGSGSAFMRFFERVLRGAWKPTQNELLNPSFMTQATILCSILLTMETLDYIPIDAPELMLMLTTLLVGYKMASVVF
......||..|...|.|.|... .|...||.|||..||||..|| |....| .||.|..   ...|   ||....| .||  |..... 
kesllvmvlvGllkGaGaalvknveqlvrGvwkpesnellkmsfttkvsllaailftlqkkkvlaiskheLvflvtlflvlikvsllll
fn3 Fibronectin type III domain 1056-1149 4.2e-11 36.0 Pfam-A 2-85 (85) alignment 
Range on Protein: 1056-1149
Range on HMM: 2-85/85.0
PPIGVKLPSSDQGSITVEWMSPNPPLGRIIGYHIQYWETFGNGstprnlsfpcQDRLCSDINYTFSTIIPHLQPDTNYSVQVRAETIRGVGDSS
.| .... .    |.|..|  |... | | || ..|.|. |..          ...  .  . | | ....|.|.|.|...|.| .  | | .|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..........ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 1164-1255 6.8e-13 41.8 Pfam-A 1-85 (85) alignment 
Range on Protein: 1164-1255
Range on HMM: 1-85/85.0
SEPQALAVSS-RSKSLLITWKEPRYPRGKIINYTLAYKVKGKPYdisfqPEDSFTmkkVAGASLSFELDDLEPATLYEVYVVASTSKGKGESS
|.|. | ||. .| || ..|..|. ..|.| .|.. |. ||..      .. .||   | . . |..| .|.| | ||. | | . .|.|..|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.....ewkeft...vprtttsvtltgLkpgteYefrVqavngagegpeS
Amnionless Amnionless 1389-1458 7.7e-06 12.4 Pfam-A 323-392 (437) alignment 
Range on Protein: 1389-1458
Range on HMM: 323-392/437.0
STEVKTGPTGGGSSVVPVVVGVIFALLLVAVVVVGVLYYR-KRRGKFSRLPASILRPRRTPPVRtNNRNQF
. . ...|. . .|.  ... |.. |.||..|.| .|..|  .  .  |||. | ..|...    . |..|
tlsesgspaspnvsfatiaalvllvlvlvglvavilllhrlpenpllprlpqwirnkrlarlae.rlrkgf
0045450 (Phosphotyrosine protein) phosphatases II 1505-1784 1.7e-90 299.1 In-house 3-304 (307) alignment 
Range on Protein: 1505-1784
Range on HMM: 3-304/307.0
ENAHQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLH---PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLEND-PHSDYVNANFI--------DG
 . ...|.. .|. .|...... ..|... .|...  . .   . ..|.. ||| |||| .|..|||.||.|  |... ..|||.||...        ||
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

YNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK--KMIYGKITVTRKSEEVNTHYTVRTFSVV---FGDNIREVVQFHY
|. .|..||.|||   .|.|||||.||.... |||||..|| ...|| .||||.  .. ||..||| .|||.  .|||||. |    . .. |.| .|||
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

TSWPDMGVPKYTTPLMNFIRTVKQHHTN--SVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENA---IDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
|.|||.|||... .| .||. |.... .  . | ..||||||||||||||... ||.| |.|.    .|... .  .|. | ..||  |||.|.|.||||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

TF
 .
ll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1506-1820 1.3e-210 692.7 In-house 1-315 (315) alignment 
Range on Protein: 1506-1820
Range on HMM: 1-315/315.0
NAHQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGP
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||..|||||||||
nahqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgp

NVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNF
||||||||||.|.|||.||||||||.|||||||.||||||||.||||||||||||||||.|||||.|||||||||||||.||||||||||||||.||||.
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnl

IRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLA
||||||||||||||||||||||||||||||||||.||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||.||||
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydslla

PSPDTGSTLLQEQFE
|||||||||||||||
pspdtgstllqeqfe
subfamily_PTPRA_pd Subfamily PTPRA 1506-1792 8.4e-100 328.8 In-house 9-303 (330) alignment 
Range on Protein: 1506-1792
Range on HMM: 9-303/330.0
NAHQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLH-PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQG
. . |.|...|   . ...|   . |.......| |...  |..|.| |||.|||..||. ||.||| |. .|  ..|||.|| |||||.   ..|||||
kkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqG

PNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK-MIYGKITVTRKSEEVNTHYTVRTFSVV-FGDNI-----REVVQFHYTSWPDMGVPK
|   .|.|||||.|| .   |||||.  | .. ||..||||.  . ||.|.|. . |.|  .|||| | |   .|.      | | |||.|||||.||| 
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPf

YTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIA
 .  ...... ||. . .| |.||||||||||||||||.|||.|.. .||. .||..|.  .|..| .|||  |||.||| .||| .. ||| . 
epiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteld
subfamily_PTPRB_pd Subfamily PTPRB 1507-1784 1.1e-98 324.9 In-house 3-285 (293) alignment 
Range on Protein: 1507-1784
Range on HMM: 3-285/293.0
AHQPIPLDQLITYVAQKKASTKNGFKQDYESIPG-GQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGP
 ..|| |... ..|...|| .. .|...||..   |. .  ..|.. .|..|||| ||..||||||.|  |.....|||.|||.|.||| || .||.|||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

NVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK--KMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLM
   .|.||||||||. .  |||||..||. | |||.|||..   ..||.|.|| ..||. .....|....  ....|.| |.|.||||| |||. |..|.
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktll

NFIRTVKQHH--TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
.|.|||....  |.| . ||||||||||||||||.|| .|.. | |. .|.. ... .|..|  .||  .|| ||....|. .
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1507-1793 2.9e-81 267.8 In-house 6-293 (297) alignment 
Range on Protein: 1507-1793
Range on HMM: 6-293/297.0
AHQPIPLDQLITYVaQKKASTkNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYprRYIAAQGPN
  .|||| .. |.| ||. .| . |....  .|  ...|  ||.|  | .|.|| ||. || |||.|  ...|| |||||| |. |...  |.|. | |.
errpiplsdfatlv.qknrht.dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPm

VASVKDFWRMVWEEDCGKIVMLTNTVEGEKrKCEKYWPDKKMI-YGKITVTRKSEEVNTHYTVRTFSVVFGD-NIRE-VVQFHYTSWPDMGVPK--YTTP
 |.|.|||.||..|.   ||||..  |..| || .||.|| .  .|...|. .| .  . .  |...|  |.   |  | |.....|||  |..   .. 
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

LMNFIRTVKQHH-TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQ
|...|  |.... .|. | ..|||.||||||| ..|.| .. .|. |...|...... .||.| ..||  |||.|.| |.||.... || |  
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
subfamily_PTPRD_pd Subfamily PTPRD 1508-1858 8.4e-134 442.2 In-house 2-354 (564) alignment 
Range on Protein: 1508-1858
Range on HMM: 2-354/564.0
HQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNV
..||| ..| ..||. ||. .  |...|..|  || .. ..|.| .||.|||| ||.||||||| |  .|.|. |||.||.|||||. .. |||.|||  
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK-KMIYGKITVTRKSEEVNTHYTVRTFSVV--FGDNIREVVQFHYTSWPDMGVPKYTTPLMN
 ...||||||||...  |||||...| .| ||.||||.| .  ||..||| ..||  ..|..|||..     .. ||| |||.||||| |||...|.|..
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLL
.||.|......  | ||||||||||||||||..||||.....|. .|.|.... .|..|  |||  |||.||..|.||   ||.|..  . . |.   | 
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

APSPDTGSTLLQEQFERLDmFTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSR
  ..||..| |.  |.||   . .   .|  .| .. | .|||. . |.....|
eveedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilalescr
0051299 (Phosphotyrosine protein) phosphatases II 1508-1784 1.4e-99 328.5 In-house 2-286 (288) alignment 
Range on Protein: 1508-1784
Range on HMM: 2-286/288.0
HQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLH-PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPN
. .|....|. .| ...|. ..|... .| ..  . . .| .|.. ||..|||| .|..||||||.|  |.....|||.||..|||||..|..||.||| 
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

VASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP-DKKMIYGKITVTRKSEEVNTHYTVRTFSVV------FGDNIREVVQFHYTSWPDMGVPKYT
  .|.||||||||...  |||||..|| ...||..||| .....||.|||| .||||. .|||||. |.      .... |.| .||||.|||.||| ..
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
..|..|.| |.... .. | .|||||||||||||||.|| .|.| |.|. .||....  .|. |  |||  |||.|.|.|||| .
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1508-1819 2.6e-99 327.3 In-house 2-318 (319) alignment 
Range on Protein: 1508-1819
Range on HMM: 2-318/319.0
HQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNV
...|....| ... . ............. . ...   .| |.| |||.|||| ||.|||..||.|. |.. . |||.||.|||||.  ...||.|.|  
dteievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

ASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK-MIYGKITVTRKSEEVNTHYTVRTFSVVF-GDNI--REVVQFHYTSWPDMGVPKYTTPLM
  ..|||||||||..  .||||. ||  | |..||||... . ||...|| ..||   .| .| ...    ...  |||..|.||.||| .||...| |.
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

NFIRTVKQHHTN-SVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPS
.... ... . . . | ||||||||||||||||.|||||.. . |...||....  .|  |  |||  |||.|||.||||   .||| |  .   .|  .
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

LLAPSPDTGSTLLQEQF
|    .||| | |. .|
laekvadtgetgleref
0050432 (Phosphotyrosine protein) phosphatases II 1508-1787 1.6e-97 321.8 In-house 23-302 (308) alignment 
Range on Protein: 1508-1787
Range on HMM: 23-302/308.0
HQPIPLDQLITYVAQkkASTKNGFKQDYESIPGGQL-HPLDVAKKIENKQKNRYINIIAYDHSRVQLpllenDPHSDYVNANFIDGY--NYPRRYIAAQG
. ......|. .. .  |  . .... .| ..  .  .. .||.. ||| |||| .|..|||||| |     |..|||.||...|||  ..||..||.||
slklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqg

PNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD----KKMIYGKITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKY
|   .|.||||||||...  |||||..|| .. ||..|||.    . ..|||.||| .||||. .|||||. ...  ... |.| .||||.|||.||| .
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps

TTPLMNFIRTVKQHHTNsvGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCG
...|..|.. |.... .  | ||||||||||||||||.|| .|.| |.|. .||.. .  .|. |  |||  |||.|.|.|||| . . 
peilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0039614 (Phosphotyrosine protein) phosphatases II 1508-1786 2.2e-91 301.7 In-house 11-291 (297) alignment 
Range on Protein: 1508-1786
Range on HMM: 11-291/297.0
HQPIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHpLDVAKKIENKQKNRYINIIAYDHSRVQLPLLEN-DPHSDYVNANFIDGYNY-PRRYIAAQGP
. ||||. |  ..  .||. |.......|...  .     .|...||| ||||..|..||||||.|  ... |..|||.||...|||.. .|..||.|||
sipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP

NVASVKDFWRMVWEEDCGKIVMLTNTVEGEKrKCEKYWPDKKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNF
.  .|.||||||||...  |||||..|| .. ||..|||..   ||..||| ...|.. .|||||..|. ..  |.| .|.||.|||.||| ... |..|
lpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllef

IRTVKQHHTN--SVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVC
.. |.... .  . | ..||||||||||||||... ||.| | |  .||.. .  .|. | ..||  .||.|.|||||| . .
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1509-1796 2.2e-95 314.3 In-house 2-295 (305) alignment 
Range on Protein: 1509-1796
Range on HMM: 2-295/305.0
QPIPLDQLITYVAQKKASTKNGFKQDYESIPGGqLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVA
..| ||.| .|. .... ...|....|.|..    ...|| || .||.|||. .|. .|..|..|   |....|||.||...|||.   .||.||||   
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

SVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKMI---YGKITVTRKSEEVNTHYTVRTFSVVF---GDNIREVVQFHYTSWPDMGVPKYTTPL
 |.||||...||   .|||||..|||.| ||..|||..|     .|...|. |||.  . |. | ... .    .. | |.|.. |.||| |||...| |
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

MNFIRTVKQHHTNSVG-AIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLY
...|. |.... .. | ...|||||||||||.||..| .|.....|. .||.. .  .|..|.||||  .||.|..||| |   ||||||  . .
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1509-1820 5.4e-87 286.6 In-house 1-313 (315) alignment 
Range on Protein: 1509-1820
Range on HMM: 1-313/315.0
QPIPLDQLITYVAQKKAStkNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVA
||||. |. ..| ... .    | ...  .|. . ..  ||.. .| .|||| ||. .|..||.| .....|.|||.|| .| ...  . |||.|||. |
qpipvaqfpafvnknrht..alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka

SVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD---KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNF
||.||||||..|.   |||.|.  ||.| || .||||   . . .|.| |.  | | .|  ..| . .  ... | | ||..| ||| ||.| |. |...
svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllkl

IRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLA
|. ||  . .   ...||||||||||| .|..| ...|.. ....||.||.. .|..|...||  |.| |||||.|| .   .| |    . ..   | .
ikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlht

PSPDTGSTLLQEQFE
 .  .| . . ..||
svdgsgrskmtkefe
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1509-1792 1.3e-71 236.0 In-house 2-244 (392) alignment 
Range on Protein: 1509-1792
Range on HMM: 2-244/392.0
QPIPLDQLITYVAQKKASTKngFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVA
||||  |. ..| ... |.   | ...  .|| ...|  ||.|  |..|||| ||. || .||.| .... |.|||.|| .|....  . |||.||||.|
qpipvaqfpafveknrhsal..ffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa

SVKDFWRMVWEEDCGKIVMLTNTVEGEkrkcekywpdkkmiygkitvtrkseevnthytvrtfsvvFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRT
|..||||||..|.   |.|.|.  ||.                                        ||. | | |||.| ||| .|||.|. |..||. 
slddfwrmvfqenvttiamvtklkegd.......................................kgddartvaqfhftewPdkdvpkhtssllkfike

VKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIA
|| .. .    ...||||||||||  |..|... .|.    .||.||.| .|..|  |||. ||| ||| |.|| ..  .| | 
vkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlip
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1509-1593 2.1e-13 44.4 In-house 4-86 (440) alignment 
Range on Protein: 1509-1593
Range on HMM: 4-86/440.0
QPIPLDQLITYVAQKKAStkNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGY
.|| . ..  || ... |    |....  .| |  .| |.|   .|| |||| ||.||||||| |  ..  |.|||.|| .|.| 
rpiivadfadyvqnnrrs..rafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
0043336 (Phosphotyrosine protein) phosphatases II 1510-1782 1.1e-92 305.7 In-house 1-275 (278) alignment 
Range on Protein: 1510-1782
Range on HMM: 1-275/278.0
PIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVAS
||.  .|. ........ | ......|...  .| . ..|...|||.|||| .|..||||||.| ||..|..|||.||...||||.||..||.|||.  .
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

VKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKMIYGKITVTRKSEEVNTHYTVRTFSVV--FGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIR
|.||||||||...  |||||. || .. || .|||.. . ||..||| ..||.. .|||||. |.    .. |.|...||..|||.|||  ...|..|..
vedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

TVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
.|...  .| |...||||||||||||||.|. .|.|.| |  .|... .  .|. | ..||  .||.|.|.||||
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1510-1835 1.2e-90 299.1 In-house 1-327 (515) alignment 
Range on Protein: 1510-1835
Range on HMM: 1-327/515.0
PIPLDQLITYVAQKKASTKngFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVAS
|.|| |. ..|....  |   | ...  .|| ...|  ||..  | .|||| ||. || .||.| .....|||||.|| .| ...  . |||.|||| ||
plplaqfPafvnknrhttl..fseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

VKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD---KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFI
|.||||.|..|.   |.|.|.  ||.| || |||||   . . .|.| |   | |  |  . |.. |. ||..| | |||.| ||| |||| |. |. .|
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllkli

RTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLAP
. ||  | .   ....|||||||||| .|..| .. .|.  ...||.||.| .||.| ..||  ||| |||.|.|| .   .| |    . .    | . 
kevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhss

SPDTGSTLLQEQFERLDMFTIKPRDDELR
    | . . ..|. |  ..  |   . |
gdgrgrskmtkefqtlkslcpdppasqtr
subfamily_Ptp69D_pd Subfamily Ptp69D 1510-1801 7.9e-89 292.8 In-house 3-303 (307) alignment 
Range on Protein: 1510-1801
Range on HMM: 3-303/307.0
PIPLDQLITYVAQKKASTKNGFKQDYESIPGGQL-HPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVA
.|..|.| . . ..|  |. |....||...  .  .   |..| ||. |||| .|.|.|. ||.|. .. . .|||.||.|| ||.  ...||||.|  |
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

SVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP-DKKMIYGKITVTRKSEEVNTHYTVRTFSVVFGD-------NIREVVQFHYTSWPDMGVPKYTT
 ..|||||..| .   ||||.|  | ...||.|||| .... ||.| |.  |||  ..|. |...|   .       . |.|||.|||.|.|. ||. ..
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar

PLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRY
 |...|. |.... .. . |||||||||||.|.|..|| .|.| .||. .|..... ..|..|  .||  |||.|.| |||..   ||| .. | . ...
gllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledai

P
 
e
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1510-1604 9.3e-13 42.2 In-house 4-95 (95) alignment 
Range on Protein: 1510-1604
Range on HMM: 4-95/95.0
PIPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLpllENDPHSDYVNANFIDGYNYPRRYIAAQG
|| .  . ..| . .. . . | ... ||.     |  |     |  |||..||. || .|| |        |||.|| |.|||     ||||||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvl...ttkrdsdyinacfvdgyarkncyiaaqg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1511-1822 2.6e-104 343.7 In-house 2-318 (318) alignment 
Range on Protein: 1511-1822
Range on HMM: 2-318/318.0
IPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDV-AKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVAS
|....| . |.. ..| .  ....|| .   . ..  . . .  ||.||||.||.||||.||.|  ||... |||.|||.||||.  . |||||.|    
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK-MIYGKITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFI
..|||||||| ..  |||||...|  |.|...|||.|. . |||..|. |.|   ..|..|.|.|     .. |.| |.||||||| |||. .. |....
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RTVKQHH-TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLA
|.|.. . ....|.|||||||||||||.||..|..|....||. .||..... .|..|  |||. .||.||||.|||   .||| .  .   .|   |  
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

PSPDTGSTLLQEQFERL
..|..| | .. .|.||
qdpesgttemdaefqrl
subfamily_PTPRG_pd Subfamily PTPRG 1511-1793 1.3e-93 309.1 In-house 1-296 (563) alignment 
Range on Protein: 1511-1793
Range on HMM: 1-296/563.0
IPLDQLITYVAQKKASTKNGFKQDYESIPGG---QLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPH-SDYVNANFIDGYNYPRRYIAAQGPN
.|....  .||. .|... ||....|..      .  . . ..| |||.||||.||.|||.|||.|  | .  .  ||.|||.||||.  . .||.||| 
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

VASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP-DKKMIYGKITVTRKSEEVNTHYTVRTFSVVF--------GDNIREVVQFHYTSWPDMGVPK
   ..|||||.||.    |||.|| || ..|||. ||| |. . ||...|| ..||| . |||||...           |. ..| |.|||.|||.|||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

YTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQ
...| ..|..  .. . . .| ||||||||||||||.| ||..| | ..|||..|..|.  .| .|  .||  |||.|..|||||.   ..| . .
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketella
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1511-1790 3.3e-73 241.2 In-house 2-284 (287) alignment 
Range on Protein: 1511-1790
Range on HMM: 2-284/287.0
IPLDQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKI--ENKQKNRYINIIAYDHSRVQLPllenDPHSDYVNANFIDGYNYPRRYIAAQGPNVA
||....  .||. .|  ..|||. .  .   . .. .|  .|  .||.|||. .|. .|  || |     . | ||.|| |||||.  ...|.|..| . 
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

SVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK-MIYGKITVTRKSEEVNTHYTVRTFSVVFGD---NIREVVQFHYTSWPDMG-VPKYTTPLM
 ...||......    ||||..  | ....| .|||..| ...|. ...  .||||..|..|.. |   .   . ..|.|...|.|.. | |... | |.
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

NFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTS
 . . .|... .. ..||||||..|||...|.  .  ..... | .|||.. .  .|. . ..|| .|||.||.|..||   ...| 
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1511-1784 1.6e-70 232.2 In-house 2-283 (290) alignment 
Range on Protein: 1511-1784
Range on HMM: 2-283/290.0
IPLDQLITYVAQKKASTKNGFKQDYESIPG-GQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLE--NDPHSDYVNANFIDGYNYPRRYIAAQGPNV
||.|..  .||...|  ..||.......    . |   |.   .||..||. ||. ||  |. |  .   .|   .|.|| .|.||.  ..|||.|||  
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK--KMiYGKITVTRKSEEVNTHYTVRTFSVVFGDN---IREVVQFHYTSWPDMG-VPKYTTP
  ..|||...|.|..  |||||| .| .| || .||||.  |. ||.....  .||. ..|. |...|   ..    ..|.|.. |.|.. | |....| 
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

LMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
|. . . .|... .  ..||||||..|||...|....  ..... |  |||.. .  .|. . ..|| ..|||.|.. .|. .
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPN9_pd Subfamily PTPN9 1513-1782 1.4e-75 249.1 In-house 3-288 (297) alignment 
Range on Protein: 1513-1782
Range on HMM: 3-288/297.0
LDQLITYVAQKKastKNGFKQDYESIPGGQLH-PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVK
...|..|| .|.   |.| ...|. |   . .  ....|.  | .|||| ... ||..||.|. ...|..|||.||||.|||. .. .||.|||    |.
ieelvayvkekg...krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

DFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP---DKKMIYGKITVTRKSEEVNTHYTVRTFSVV--FGDNIREVVQFHYTSWPDMGVPKYTTPLMNFI
||||||||...  ||| | .||  ..|| .|||   .. . .|...|.. . |.. .|.||.. .     ...|.|. | ..|||| |||. .. |....
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvl

RTVKQHHTNSVG-------------AIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
..|... . .|               ||||||||.||||||||||  |.. | .. .|| . .  .|. |  ..|. |||.| | |.||
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPRK_pd Subfamily PTPRK 1514-1820 1.3e-101 334.5 In-house 7-313 (314) alignment 
Range on Protein: 1514-1820
Range on HMM: 7-313/314.0
DQLITYVAQKKASTKNGFKQDYESIPGGqlhpLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDF
. |.  .|. |..   |||..|||.. |     |.||| ||..|||. .|.|||.|||.|  ...||.|||.||..||.|. |. .|..|||    ||||
adllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdf

WRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKMIYGKITVTRKSEEVNTHYTVRTFSVVF----GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTV
||.|..|.|  |||||. ||  . || ||||.. ..||.| |.  . |... . ||.|.|       ..|||| ||....||| .||.. | |....| |
WrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrv

KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLAPSPD
|... .. | |||||||| |||||||..| .|| .| |. .||.| .  .|.... ||.. |||.||||..||. .||.|.|    .   | . .   |.
kksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpq

TGSTLLQEQFE
| |. |.|.|.
tnssqlkeefq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1514-1820 5.8e-78 257.3 In-house 8-324 (325) alignment 
Range on Protein: 1514-1820
Range on HMM: 8-324/325.0
DQLITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDF
 .|. .| .|||  ..|| .... .|  .     || | |||.|||. |..|.|.||| |  ...||.|||.||...  .     ..||| |. |...|.
vnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindl

WRMV--WEedcGKIVMLTNTVEGEKRKCEKYWPDK---KMIYGKITVTRKSEEVNTHYTVRTFSV--VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFI
||.|  |.     .|...| ....| .| .|||..      .| . |  .. |  . |  | . |  | . . | | ||.. ||.||||.|. . |....
WrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

RTVKQHH------TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRY
..||. .      |.. . |.|||||||||||.||.| ..|..   |  .|...|.  .|..| .||. ..|| .||.|| |....|.| .    .  . 
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeakl

PSLLAPSPDTGSTLLQEQFE
 ||    | |    ....||
sslqernpltqklniekefe
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1516-1791 5.1e-94 309.9 In-house 14-297 (298) alignment 
Range on Protein: 1516-1791
Range on HMM: 14-297/298.0
LITYVAQKKASTKNGFKQDYESIPGGQL----HPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVK
|  ..| ||. .  |...... .  ..     .  .||.| |||.|||| .|||.|.||| |   ..| .|||.|| |...|.    .||.|.| ...|.
lqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetve

DFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD-KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGD--NIREVVQFHYTSWPDMGVPKYTTPLMNFIRT
||||||.||| | ||||||..| .| |..||||| .|  ||.|||. .|.|. . ..||.. |   .  . |||.|.|.||||| |||...| .....| 
dFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrk

VKQhHTNSVG--AIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSI
|.. ...  |  ...|.|||||||.|||| .|..|.....|. .||.. .  .|..|...||  ||| |||.| || . .... |
vra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1516-1784 1.6e-37 123.9 In-house 9-287 (305) alignment 
Range on Protein: 1516-1784
Range on HMM: 9-287/305.0
LITYVAQKKASTKNGFKQDYESIPG-GQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLplLENDPHsDYVNANFIDGYNYPRRYIAAQGPNVASVKDFW
.. .| .    . .|..... ..    ... .   |. ....|||| ..   |. ||.|      || .|. ||..     |.|.| .| |   .  |||
ilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl..egpwph.eyihanyvstptnpkrfictqaplektcadfw

RMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK---MIY----GKITVTRKSEE-----VNTHYTVRTFSVV---FGDNIREVVQFHYTSWPDMGVPKYT
 | ...   .| || | .|   .|| .|.. |.   . .     ||.|  .| .      ... .|.   .|    | . | | ..|.  ||| |||   
ymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaad

TPLMNFIRTVKqhhtNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVY-NFITGMRQNRIKMVQVAEQYQFIYDALLETF
. .....   .     | | ||||||||.||||. . |. .|||  | . |.     .  .|..| . .|  .|| |... .|. |
lailellekar....pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
0040438 (Phosphotyrosine protein) phosphatases II 1517-1819 1e-95 315.9 In-house 6-311 (317) alignment 
Range on Protein: 1517-1819
Range on HMM: 6-311/317.0
ITYVAQKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRM
. .. . ..| ...... .| ..  .|.. .||.. |||.|||| .|. ||||||.|  |..|..|||.||...||.|..|..||.|||   .| |||||
llalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrm

VWEEDCGKIVMLTNTVEGEKRKCEKYWP-DKKMIYGKITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH
|||.... |||||...| ...||..||| .... ||..||| .|||.. ..|.||. |.   ... |.| .||||.|||.|||.....| .|.. |... 
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLYLQRYPSLLAPSPDTGST
 .. | ..||||||||||||||... ||.| | |. .||.. .  .|. | ..||  |||.|.|||||| . ...|..    .  ... ||.| . ....
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvk

LLQEQF
| ....
lkekel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1517-1782 1.5e-95 314.6 In-house 9-277 (288) alignment 
Range on Protein: 1517-1782
Range on HMM: 9-277/288.0
ITYVAQKKASTKNGFKQDYESI-PGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWR
...||.|.|....||...|.|. . .. .  ..... .|..|||| ||..||. ||.|  ||. . .||.||..|||..  ..|||.|||. ..|.|||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKM--IYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH
.|.|..   |||||. |||.|.|||.||||..    ||..||| ....  .....|.. ..   . .|. |..|..|||.|||. ..||....|.||. .
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvan

TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
.. .| |.||||||||||||||.|||..|. |.|. ||| .... .|..|  .||. .||.|||..||.
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1517-1783 3.1e-89 293.8 In-house 3-275 (281) alignment 
Range on Protein: 1517-1783
Range on HMM: 3-275/281.0
ITYVAQKKASTKNGFKQDYESIPG-GQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWR
 . ..|.... ..||...||..   |. ..   .|. ||..||||.||.|||..||..   |.. ..||.||||..||. ...|||.|||  ||...||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK--MIYGKITVTRKSEEVNTHYTVRTFSV-VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQH
||||..  .|||.|. .|..| || .||||..  ..||..||. ..|| ...|  |.|..   . . |||.|..||.||| |||. |. |..| . |.. 
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

H-TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAE-NAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
. ...  ..|.|||||||||||.|.|| .....||| . .|| . .. .|..|  |||   ||.|.| |.|..
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_PTPN6_pd Subfamily PTPN6 1522-1781 8.6e-81 266.3 In-house 19-294 (306) alignment 
Range on Protein: 1522-1781
Range on HMM: 19-294/306.0
QKKASTKNGFKQDYESIP---GGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPlLENDPHSDYVNANFIDG--YNYPRRYIAAQGPNVASVKDFWRM
...  .|.||....|..      .|.  . ..|.|||.|||| ||. .||.|| |   .. | |||.|||.|..   .  ..|||.||   . |.|||||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

VWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK--MIYGKITVTRKSEEVNTHYTVRTFSV---VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQ
||.|..  |||.|. ||  | || .||||..    ||||.||  ||. ...|..|..||    .... |||.|.|..|||| |||| .  ...|...|..
vwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

HHTNSV----GAIVVHCSAGVGRTGTFITLDAMLDQAEA---ENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
.. ..     |.||||||||.||||||| .|..|.. |    .  ||.....  .|. |  .||...||.|.| |. 
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1522-1789 1.4e-58 193.0 In-house 8-298 (301) alignment 
Range on Protein: 1522-1789
Range on HMM: 8-298/301.0
QKKASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLEN--DPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWE
.. |  .|.|...|...  |. .. .|  . |||. ||. ||  ||. |. |   .|    . .|.||..||||.  ...||||||    ..||||..|.
hvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

EDCGKIVMLTNTVEGEKRKCEKYWPD---KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDN-----------------IREVVQFHYTSWPDMGV-PKY
|   .|||.||. || | |||.|||.   ..  .|..||| ..| |   ...| ..|.  |                   ..|.|.. |.||. || . .
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

TTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDT
 | |.     ... .  . | .|||||..|.|.|......  |.|. ||  .||.. .  .|... ..|.  ||| .|||.. ... . .|
rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
0047943 (Phosphotyrosine protein) phosphatases II 1523-1782 2.2e-92 304.7 In-house 6-270 (273) alignment 
Range on Protein: 1523-1782
Range on HMM: 6-270/273.0
KKASTKNGFKQDYESIPGGQL-HPLDVAKKIENKQKNRYINIIAYDHSRVQLplleNDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEED
.|.. ...... .| ..  .  ..  ||...|||.|||| .|..|||||| |    .|..|||.||...||||..|..||.|||   .|.||||||||..
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

CGKIVMLTNTVEGEKRKCEKYWPDK----KMIYGKITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTN
.  |||||..|| ...||..|||..    ...|||.||| .|||.. .|||||. ...   .. |.| .||||.|||.||| ....|..||. |.... .
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--SVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
  | | .|||||||||||||||.|| .||| |.|. .||.. .  .|. |  |||  |||.|.|.||||
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_CG7180_pd Subfamily CG7180 1524-1788 3.9e-60 198.0 In-house 12-294 (296) alignment 
Range on Protein: 1524-1788
Range on HMM: 12-294/296.0
KASTKNGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCG
.   .  .|. .. .|  .      . . ||..|||..... ||. || |. |. . .|||.|| ..|..  .. ||  ..|   .|..|||.|..|.. 
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

KIVMLTNTVEGEKrKCEKYWPDK-KMIYGKITVTRKSEEVNTHYTVRTFSVVFG------------DNIREVVQFHYTSWPD-MGVPKYTTPLMNFIRTV
 .|.||.| . .| .. .||| | |  ||.| |   .|.  .. . ||| ..               . | | .|..| |.    ||  |. |....| |
avvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

KQHHTNS-----VGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGD
..   .       | .||..| |..|.| ....|| |...| |. .||....  .|..| ..|.  |.|..||| ||| ..|. 
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_PTPRN_pd Subfamily PTPRN 1525-1782 3.3e-56 185.2 In-house 25-290 (297) alignment 
Range on Protein: 1525-1782
Range on HMM: 25-290/297.0
ASTKNGFKQDYESIPGGQLHPL--DVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNyPR--RYIAAQGPNVASVKDFWRMVWEE
 . |. .....|..   . .|   .|||. .| .|||. ....||||||.|    .. .|||.|| .|   . ||   |||.|||  ..| |||.||||.
lknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd.prapayiatqgplastvadfwqmvweq

DCGKIVMLTNTVEGEKRKCEKYWPDK-KMIYGKITVTRKSEEVNT-HYTVRTFSV--VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNS
 .  ||.||.  | . ..|..||||. . .|.   |   || . .  | ||.| .  .  .. | | |||. |||..|||  . .|..| | | . .   
GvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr

VGAIVVHCSAGVGRTGTFITLDAMLDQA-EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
  .||||||.|.||||..| .| .|..     . ||.   .  .|..| ..|.  .|..|.. |. |
scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1526-1785 3e-42 139.2 In-house 8-270 (281) alignment 
Range on Protein: 1526-1785
Range on HMM: 8-270/281.0
STKNGFKQDYESIPGGQLHPLD-VAKKIENKQKNRYINIIAYDHSRVQLPL-LENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCG
 | . |||..  .||     |  | ..  |..||||.|| . | ||||| . . |   .||. ||.|      | || .|||.  .  |||||.|.|.  
mtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqentt

KIVMLTNTVEGEKRKCEKYWPDKK---MIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSvgai
 |||| . .| .. || .|.| .    . . |..|. .   ||       . . .  . | . .. .  |||  ||. .  ... .| .. . |      
aivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstpp....

VVHCSAGVGRTGTFITLDAMLDQAEAENAI-DVYNFITGMRQ-NRIKMVQVAEQYQFIYDALLETFV
|.||||||||.||.....  |.   .  .. |. . .. .|   |   ||  .|| .|.  ||.  |
vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1529-1786 4.7e-37 122.6 In-house 19-273 (288) alignment 
Range on Protein: 1529-1786
Range on HMM: 19-273/288.0
NGFKQDYESIPGGQlhPLD-VAKKIENKQKNRYINIIAYDHSRVQLPlleNDPHSdYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVM
.| |..|.  | .   . | . . |.|  ..|| |.   | .||.|    .||.  |..|| .   .|.|| | || |  . .. .|.|. |.|   |||
eglkkeyrdspnea..sidiidsfianptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivm

LTNTVEGEKRKCEKYWPDK---KMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVV---QFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTnsvgAIV
|.. .|  |.| ..|.| |   |. .|..    | . .. . .|.   .    .. | |   . |.  |.| |||.   . ....  .|...      ||
lcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....Piv

VHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVC
||.|||||||||.|    .|...  .. . . .... .|..| | .|.  || ...  .|| .. 
vhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1529-1795 3.9e-33 109.3 In-house 27-300 (310) alignment 
Range on Protein: 1529-1795
Range on HMM: 27-300/310.0
NGFKQDYESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPlLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVML
.|. ..|  .   |   |      .. .|||| ...  | |||.|  ...  . ||. ||..        .| .|||   .. |||||...| .  |..|
eglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilll

TNTVEGEKRKCEKYWPDKKM--IYGKITVTRKSEEVNtHYTVRTFSVVF-GDNI---------RE--VVQFHYTSWPDMGVPKYTTplmnfiRTVKQHHT
 ...|  . ||  |||   .   || | ||  ||  .  . .  ..| |  ||.         .|  |   ..  |||.|||           || |   
ckvgeegrpkcvgywpslgvtetygcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc......htvpqrll

NS--VGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIyDALLETFVCGDTSIAQDL
     |  |||||||..|... ..|.  .|...  . .|. . .| ....|.. .|   || .| | .   |. |.| .|...
aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii.drvriifargetevaeki
0046845 (Phosphotyrosine protein) phosphatases II 1531-1788 2.2e-94 311.3 In-house 2-278 (284) alignment 
Range on Protein: 1531-1788
Range on HMM: 2-278/284.0
FKQDYESIPGGQLH---PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLEND-PHSDYVNANFIDGY-----NYPRRYIAAQGPNVASVKDFWRMVWEED
.....| ..  . .   .|.||.. ||. |||| .|..|||||| |  |..| ..|||.||...|||     ......||.|||   .|.||||||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CGKIVMLTNTVEGEKRKCEKYWP--DKKMIYGKITVTRKSEEVNTHYTVRTFSVVF---GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHT--
.  |||||..|| .. ||..|||  .....||..||| .||||. .|||||.....   ... |.| .||||||||.||| ....|..|.|.|.....  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

NSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAEN---AIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGD
.. | ||||||||||||||||.|| .|.| |.|.    .||.. .  .|. |  |||  |||.|.|.|||| . .. 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0036941 (Phosphotyrosine protein) phosphatases II 1531-1789 2.1e-92 304.9 In-house 15-282 (297) alignment 
Range on Protein: 1531-1789
Range on HMM: 15-282/297.0
FKQDYESIPGGQ-LHPLDVAKKIENKQKNRYINIIAYDHSRVQLplleNDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLT
... .|...  . | .|.||.. ||..|||| .|..|||.||.|    .|..|||.||...|||...|..||.|||   .| ||||||||...  |||||
llkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NTVEGEKRKCEKYWP---DKKMIYGKITVTRKSEEV--NTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTN--SVGAI
. || .. ||..|||   .. . ||..||| .|.||  ...||.||. |..  ... |.| .||||.|||.||| ....|..||. |.... .  | | .
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpv

VVHCSAGVGRTGTFITLDAMLDQAE---AENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDT
.|||||||||.||||..| ||.| |    |. .|.....  .|. |  .||  |||.|.|.|||| . ...|
lVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_PTPN14_pd Subfamily PTPN14 1533-1782 6.1e-56 184.6 In-house 27-294 (300) alignment 
Range on Protein: 1533-1782
Range on HMM: 27-294/300.0
QDYESIPGGQLHP-LDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDpHSDYVNANFIDGY--NYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLT
..|| ||  ...  |..||  ||..|||. ... |...||.|   ... ...|.||  |        | ||.||||    |.|||.||||..   |||||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NTVEGEKRKCEKYWPDK-----KMIYGKITVTRKSEEVNTHYTVRTFSV--VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVK---QHHTNSV--
.. |. | |. ||.|..     .. .||  || |  |  . .. ... .  .   . |.|. . || ||| |||.  .. ..... |.   .. ...|  
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

----GAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
      ..|||||||||||  |. | ..   | .. ||. . .. .|. |  .||   ||.|.|..|..
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
0045098 (Phosphotyrosine protein) phosphatases II 1535-1787 4e-78 257.9 In-house 14-275 (278) alignment 
Range on Protein: 1535-1787
Range on HMM: 14-275/278.0
YESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQlpllendphsDYVNANFIDGYnyPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEG
.. .. |.     .| ...|. |||| .|..||||||           ||.||..||||  |...||.|||    | |||||.||...  |||||. ||.
efllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

EKRKCEKYWPDKK-MIYGKITVTRKSEEVNTHYTVRTFSVV------FGDNIREVVQFHYTSWPDMGVPKYT--TPLMNFIRTVKQHHTN----------
.. ||..|||... ..||..||| .||||. .||.||. |.       ..  |.| ..||..|||.||| ..  ... .... ..... .          
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

---SVGAIVVHCSAGVGRTGTFITLDAMLDQAeaENAIDVYNFITGMRQNRIK-MVQVAEQYQFIYDALLETFVCG
   | | ..||||||||||||.. .. ||..   |. .|... .. .|. |   .||  |||.|.|..||| . .|
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_CG42327_pd Subfamily CG42327 1535-1710 3.3e-31 103.1 In-house 11-191 (319) alignment 
Range on Protein: 1535-1710
Range on HMM: 11-191/319.0
YESIPggQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVE
.. .|  ||     .  .  |.|.|.||..   ..|| |.   .|... |..|... ||.  |  ||||| .   |  ||||.|||     || ||.  |
frdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlse

GEKRKCEKYWPDK-----KMIYGKITVTRKSEEVNTHYTVRTFSV--VFGDNIREVVQFHYtSWPDMGVPKYTTPLMNFIRTVK
   ..| .|.| |     .  ||.| || |  ||. .| . |. .  | ... ||.  . |  |.. .||   ..|.  .  |.
lGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1536-1782 1.1e-66 219.6 In-house 2-262 (270) alignment 
Range on Protein: 1536-1782
Range on HMM: 2-262/270.0
ESIPGGQLHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEG
. .. .. .. |. . . .|. ||| .|.   ..||.|. ||.|... |.|||.. |..  ...||||.||  ...|.||||.|||    |||.|. .| 
keldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEk

EKRKCEKYWPDK-----KMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTT------PLMNFIRTVKQHHTNS--VGAIV
 ..|||.||| .     |. .|||.|.  ||| .. | ..   .    ..|..| |.|..||| |||. .        |.. .|.|......    . ..
grkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePll

VHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
||||||||||||.|.|| ..   | .. .|| . |. .|..|...||  |||.|.| |..|
vHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
DSPc_SM00195 1543-1784 2.2e-87 288.1 In-house 15-262 (263) alignment 
Range on Protein: 1543-1784
Range on HMM: 15-262/263.0
LHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKY
 .. . |.| .||.|||| ||. |||.||.|.  |....|||.|||.|.|.|....|||.|||    |.|||||||||..  |||||. .| .|.||..|
pketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

WPDK---KMIYGKITVTRKSEEVNT-HYTVRTFSVVFGD--NIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFIT
||..   |. .|||.|. ...|    ....||... . .  . |.| |..|..||| |||. |.......|.||... .| | |||||||||||||||.|
wpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

LDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
.| .|.. |.|. .|. . .. .|..|..|||  |||.|||.|.|| .
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1543-1784 2.2e-87 288.1 In-house 15-262 (263) alignment 
Range on Protein: 1543-1784
Range on HMM: 15-262/263.0
LHPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKY
 .. . |.| .||.|||| ||. |||.||.|.  |....|||.|||.|.|.|....|||.|||    |.|||||||||..  |||||. .| .|.||..|
pketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

WPDK---KMIYGKITVTRKSEEVNT-HYTVRTFSVVFGD--NIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFIT
||..   |. .|||.|. ...|    ....||... . .  . |.| |..|..||| |||. |.......|.||... .| | |||||||||||||||.|
wpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

LDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
.| .|.. |.|. .|. . .. .|..|..|||  |||.|||.|.|| .
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN1_pd Subfamily PTPN1 1544-1792 6.6e-65 213.7 In-house 22-281 (290) alignment 
Range on Protein: 1544-1792
Range on HMM: 22-281/290.0
HPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENdphsDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYW
.|  .||. ||...||| ..  |||||..|   .|    ||.||....  .  |.|| .||| .  |. ||.||||...  .||| . || |. || .||
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

P----DKKMIYG--KITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH--TNSVGAIVVHCSAGVGRTGT
|    .|....   |..|.  |||.. .||||.. .     .. ||...||||.|||.|||.  . ...|.  |..    .. ||  |.|||||.||.||
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FITLDAMLDQAEAE---NAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE--TFVCGDTSIA
|. .|..| . |..   ...|. . .  .|. |. ..| |.| .| | |.||   .. ||.|. 
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvq
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1544-1793 3.7e-58 191.7 In-house 23-275 (283) alignment 
Range on Protein: 1544-1793
Range on HMM: 23-275/283.0
HPLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENdphsDYVNANFID---GYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCE
 . |.|   |||.|||. .|...|  ||.|  . .    ||.|| ||     |.  ..||.||.|    |.|||.||..|.   |||||.  |... || 
ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

KYWPDKKMI-YGKITVTRKSEEVNTHYTVRTFSVVFG---DNIREVVQFHYTSWPDMGVPKYTTPL--MNFIRTVKQHHTNsvGAIVVHCSAGVGRTGTF
.||| .  . ||. ||| . |  .  .... . .       .   .  . .  | ..|       |  .| ... .... .  | ||||||.|.|||..|
qyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskk..gPivvhCstgiGrtavf

ITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQ
|.. | ...| .|  .||.. .. ||..|. .||  .||...... ||  .|||| || 
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaa
subfamily_PTPN12_pd Subfamily PTPN12 1545-1784 4.4e-80 263.7 In-house 31-277 (290) alignment 
Range on Protein: 1545-1784
Range on HMM: 31-277/290.0
PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP
. ....| ||..|||| .|. ||.|||.|   |....|||.||||| | . . .|||||||  . ..|||||.|| .   .||. . || .| |||.|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DK---KMIYGKITVTRKSEEVNT-HYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDA-
..   .. .|...|| ..|.  .  ...||. | . .. |.| |||||.||| |||. ...|...|..|.......   .||||||||||||| |..|  
eegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyv

--MLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
  .| .   .. .||.. .. .|..|  .||  |||...| |..| .
rellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_egg_pd Subfamily egg 1545-1782 4.3e-24 79.7 In-house 31-268 (307) alignment 
Range on Protein: 1545-1782
Range on HMM: 31-268/307.0
PLDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGekRKCEKYWP
.|  | . .|..| |   .   | |||.| | .     |.. || ..|      .| || |   .|.||||||..|..  ||||| ..|    .|| |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

DKK-----MIYG--KITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGvpKYTTPLmNFIRTVKQHHTnsvgAIVVHCSAGVGRTGTFITL
  .     .. |  .|.  .  .. .  ..|  . .| ||.    ..     .  ..  .  .|| . .| ...  .     .||..  || ...|....
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnss..dvyspl.rvlrklrnlsk....pvvvqdilGvskaatlvai

DAMLDQAE--AENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
.  | .          | . .  .|..|   |. . .| |.|  .| 
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
0040439 (Phosphotyrosine protein) phosphatases II 1546-1784 2.8e-82 271.3 In-house 3-246 (249) alignment 
Range on Protein: 1546-1784
Range on HMM: 3-246/249.0
LDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP-
 .||.. ||| |||| .|..||||||.|  |.. ..|||.||..||||...||.||.|||   .|.|||||.||.... |||||..|| .. ||..||| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

DKKMIYGKITVTRKSEEVNTHYTVRTFSVV--FGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTN--SVGAIVVHCSAGVGRTGTFITLDAM
.. . ||..||| .|.||. .|||||. ..    .. |.| ...||.|||.|||... .|..||. |......  . | ..||||||||||||||... |
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

LDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
|.| | |. .|... .  .|. | ..||  |||.|.|.|||| .
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN3_pd Subfamily PTPN3 1546-1783 2.2e-66 218.6 In-house 33-274 (280) alignment 
Range on Protein: 1546-1783
Range on HMM: 33-274/280.0
LDVAKKIENKQKNRYINIIAYDHSRVQLpllENDPHsDYVNANFI----DGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEK
...|.| || .|||| .|..||. ||.|   .. .  ||.|||..    .. .   ||||.|||   ...|||.||||...  |||||..||  . || .
isaarkpenlsknryrdilpydatrvkl...keset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPDK--KMIYGKITVTRKSEEVNTHYTVRTFSVVFGD--NIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITL
|||..  .. ||...|. ..|. .. | .| . .   .  . |...|. |..||| |||. .. ...|...|.. .. .   .|||||||.|||| .|.|
yWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
.  |   ||.... . . .  ||. |  .|| |.||.|. .|.|. 
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
0049772 (Phosphotyrosine protein) phosphatases II 1546-1783 1.7e-41 138.3 In-house 38-279 (314) alignment 
Range on Protein: 1546-1783
Range on HMM: 38-279/314.0
LDVAKKIENKQKNRYINIIAYDhSRVQLPLLENDPhSDYVNANFIDGYnypRRYIAAQGPNVASVKDF----------WRMV--WEEDCGKIVM------
. ||.. .|. ||||..|. .| .||.|| |...  ||| ||...||.   ...||.|||.   | ||          ||||  .. ..  |||      
ilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LTNTVEGEKRKCEKYWPDKKmiygkitvtrkseevnthyT-------VrtfsvvfgdnIREVVQFHYTSWPDMGVPkYTTPLMNF
               |..  ..    ....... |                   .       .           |........ .|| ..|  .  .  |
adelsrLdaAlgKtpllildgngneptaadlellk...................eelydpelf..........erlgikylripvpDgsap.lledfdef

IRTVKQHhtNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAeNAIDVYNFITGMRQ---NRiKMVQVAEQYQFIYDALLET
.. ....  .  |...|||.||.||||||.... .. .    .. ......  .|    |.  ...  |||.||..|||| 
lefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnp.gfieqleqyefilealley
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1546-1655 1.5e-14 48.1 In-house 40-163 (349) alignment 
Range on Protein: 1546-1655
Range on HMM: 40-163/349.0
LDVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPH--------------SDYVNANFID--GYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLT
. ... .|   |||| .|. |.||||.|.   . ..               ||.|||..    ..  ..||| | |  ..|.||....  .    .. |.
vilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLn

NTVEGEKRKCEKYWPDKKmiYGKITV
.  | . .||..|| . .  |  |||
ddkelslekcdiywqels..ysnitv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1547-1786 5.8e-85 279.5 In-house 2-244 (250) alignment 
Range on Protein: 1547-1786
Range on HMM: 2-244/250.0
DVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRkCEKYWP-D
.|||| .||.|||| .|||.|.||| |   . | .|||.|| |..||.  . .||.||| .|...||||||.||. | |||||| .| ||  ...||| .
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIRE--VVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTN-SVGAIVVHCSAGVGRTGTFITLDAMLD
|  .||..||. .|.|. . ||.|.. .    .  |  |.|.|...||| |||...|  ..... |.. . .   . ..|.|||||||.|.||..||.|.
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVC
... |. .||...|  .|..|...|.  ||| |.| ..|.  ..
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0042113 (Phosphotyrosine protein) phosphatases II 1547-1782 7.2e-81 266.5 In-house 2-241 (245) alignment 
Range on Protein: 1547-1782
Range on HMM: 2-241/245.0
DVAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP-D
.||...|||.|||| .|..|||.||.|.  ..|..|||.||...|||......||.|||   .|.|||||.||...  |||||...| .. ||..||| .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

KKMIYGKITVTRKSEEVNTHYTVRTFSVV--FGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHT-NSVGAIVVHCSAGVGRTGTFITLDAMLD
 .. ||..||| .|||.. .|||||..|.    |  |||...||..|||.||| ..  | .|.. |...   .| | ..||||||||||||||... ||.
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

QAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
|.|.|  ..... .  .|. | ..||  .||.|.|.||||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN13_pd Subfamily PTPN13 1547-1783 3.9e-63 208.3 In-house 30-268 (273) alignment 
Range on Protein: 1547-1783
Range on HMM: 30-268/273.0
DVAKKIENKQKNRYINIIAYDHSRVQLpllEND-PhsdYVNANFIDGY--NYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYW
.|.|| |||.|||| |.. ||..||.|   ... .   |.||..|     .   .|||.|||   .|||||.|||| ..  |.|.|. .|..| ||..||
evgkkkenkdknryrnvlPydetrvkl...gdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

PDKK----MIYGKITVTRKSEEVNTHYTVRTFSVVF--GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTnSVGAIVVHCSAGVGRTGTFITL
|..|    .......|.    .    ..||.. |      . |||.......||| |||. ...|..|.. |.. .| . | ||||||||.||.||.||.
PesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtliti

DAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
|..|.  | .. .|| . .  .|. |  .||  .|| |.| |.|| 
dvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1547-1660 7.7e-22 72.5 In-house 40-167 (350) alignment 
Range on Protein: 1547-1660
Range on HMM: 40-167/350.0
DVAKKIENKQKNRYINIIAYDHSRVQLP--L------LENDPHSDYVNANFIDGY------NYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTV
 ... .|   |||| ||. |.||||.|.  |            .||.|||..         |   .|||.|.|    |.||.... . .   |..||. |
ilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdv

EGEKRKCEKYWPDKKMIYGKITVTRKSE
| . .||..||.. ..   .. .. | |
elnlekcyrYWqegsydditvklaskwe
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1547-1783 4.8e-20 66.4 In-house 38-278 (303) alignment 
Range on Protein: 1547-1783
Range on HMM: 38-278/303.0
DV--AKKIENKQKNRYINIIAYDHSRVQLpllendPHSDYVNANFIDgYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP
.|   . ..| .|||....|  |||.|.|        | |. |....  .  .. | .| |   .  |||.|. |.    ...|    | .|   .  .|
svsknqfvknmdknrfvdvicldhskvkl......sdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp

DKKMIY----GKITVT-RKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPL-MNF---IRTVKQHHTNSVGAIVVHCsAGVGRTGTFI
 .. .       | |   |  |.   ....  ||  ||    .   || .||   .|  ..|  ..    ...| .....|  .. .   .|.||.||| 
rnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsl.sgcgragtfa

TLD-AMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
 .. | |   . ....|. . .  .|. |.. ||   |. ..|  | | 
lfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_eak_pd Subfamily eak 1547-1710 7.4e-20 65.6 In-house 45-208 (332) alignment 
Range on Protein: 1547-1710
Range on HMM: 45-208/332.0
DVAKKIENKQKNrYINIIAYDHSRVQLPLLENDPhSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK
 .....|. ..|  ..|. ||.  |.|     ..   |.||  ..  .  |.|| .  ..   |  ||.|| |.    ||.| . || .  | .||.|||
setarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

K---MIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTpLMNFIRTVK
    . .|.. |.||.   .  . .| . .  |..  .|  ...  | .. .|||   .. . ...|
treelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyed.flalrkvmk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1548-1782 3.3e-74 244.1 In-house 2-239 (239) alignment 
Range on Protein: 1548-1782
Range on HMM: 2-239/239.0
VAKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK
 |||  || |||| ||..|||||| |  | |||||||.||...  |.  |. |||.||   .|  |||||.|.|    |||||  .|| |.|| .|||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

KMIYGKITVTRKSEEVNTHYTVRTFSV--VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQA
   | .. || .  || . | .||| .  |   . | | |.|.| ||| |||.|.| .. . | . .         |.||||||||||.|. .|||| ||
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
. ....|..|..  .|..| .||| .||| ||. |.||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
0037934 (Phosphotyrosine protein) phosphatases II 1548-1782 3.4e-74 244.7 In-house 4-240 (243) alignment 
Range on Protein: 1548-1782
Range on HMM: 4-240/243.0
VAKKIENKQKNRYINIIAYDHSRVQLpllenDPhSDYVNANFIDGYNyprRYIAAQGPNVASVKD----FWRMVWEEDCGKIVMLTNTVEGEKRKCEKYW
.|...||. |||| .|..|||||| |     .. |||.|||.|....   |.|| |||   .|.|    ||||.||.... |||||..|| .. ||..||
iallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PDKKmIYGKITVTRKSEEVNTHYTVRTFSVVF---GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQH--------HTNSVGAIVVHCSAGVGRTG
|...  ||..||| .|||.  .|||||....    .|  |.|...||..|||.|||  ...|..|.. |...        . .| | ..|||||||||||
pgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TFITLDAMLDQAeaeNaIDVYNFITGMRQNRIK-MVQVAEQYQFIYDALLE
|.|... ||..    . .|... .  .|. |   .||  .||.|.|.||||
tliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1548-1782 8.4e-55 180.6 In-house 32-275 (287) alignment 
Range on Protein: 1548-1782
Range on HMM: 32-275/287.0
VAKKIENKQKNRYINIIAYDHSRVQLpLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK-
 |... . .|||| ... .|..|| |   | .  |||.|||.. .|.   ..||||||  |.|.||||.|.|.    ....|  ||  . || ||||.. 
aaeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

-KMIYGKITVTRKSEE-VNTHYTVRTFSVVFGD--NIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQH-----HTNSVGAIVVHCSAGVGRTGTFITL
  |  |  .|.  . .  . .|.||.. ..  .  . | | |... |||| ...  .  |. |.  ||||      .. || .|||...|.||.|.....
vPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

DAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
 ..... |    .|| . .  .|. |  .|| . |....|.||  
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1548-1705 5.8e-31 102.5 In-house 27-189 (297) alignment 
Range on Protein: 1548-1705
Range on HMM: 27-189/297.0
VAKKIENKQKNRYINIIAYDHSRVQLplLENDPHSDYVNANFIDGYN--YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD
.||.    .|||| .|.|.| .||.|  |   . .||.||...   .   . .|| ||||  |.|.|||..|.|.| . |||...  |. . ||  |||.
sakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

K---KMIYGKITVT---RKSEEVNTHYTvRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNF
    ..  |.. |    . |.| .. .    . ... .. | |    . |||| |||     |  |
vvqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1548-1639 4.8e-11 36.7 In-house 28-118 (332) alignment 
Range on Protein: 1548-1639
Range on HMM: 28-118/332.0
VAKKIENKQKNRYINIIAYDHSRVQLplLENDPHSDYVNANFIDGYNYPRRYIAAQGPNV-ASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKC
  | ..| . ||   . ..|||||.|    .| . |. ||...|||.    || || |    .   ||||| |     |... .  | .|||.
ydkflnnmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1549-1782 3e-74 244.1 In-house 2-238 (239) alignment 
Range on Protein: 1549-1782
Range on HMM: 2-238/239.0
AKKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK
|||  || |||| ||..|||||| |  | |||||||.||...  |.  |. |||.||   .|  |||||.|.|    |||||  .|| |.|| .||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

MIYGKITVTRKSEEVNTHYTVRTFSV--VFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAE
  | .. || .  || . | .||| .  |   . | | |.|.| ||| |||.|.| .. . | . .         |.||||||||||.|. .|||| ||.
skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

AENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
 ....|..|..  .|..| .||| .||| ||. |.||
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1549-1781 5e-70 230.7 In-house 23-265 (274) alignment 
Range on Protein: 1549-1781
Range on HMM: 23-265/274.0
AKKIENKQKNRYINIIAYDHSRVQL-PLLENDPHSDYVNANFIDGYNYP-RRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK
 .   ...|||| .|.  ..||| | .   .|. |.|.|||.| ||..  . |.|.||| .  |.|||||...|.. .|||||.  | ...||..|.||.
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

KMI-----YGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQH---HTNSVGAIVVHCSAGVGRTGTFITLD
. .     ||.. .. ..   . .|.||....    . |.|. . ||.|||. .|. ...|..... |..    ... ....|||||||.|||| ||. .
edyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

AMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
  . | ..|. .|| . .. .|..|  ||| .|||..|. || 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1550-1796 7.6e-67 220.7 In-house 44-291 (439) alignment 
Range on Protein: 1550-1796
Range on HMM: 44-291/439.0
KKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKrkcekYWP-DKKM
 .  .. |||| .. |.||.|| |  .   ||| |.|||.|.||  .. |||.|||.  ...||||.|.|. . .|||||| ||  |     ||| |...
aqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaev

IYGKITVTRKSEEVNTHYTVRTFSVVF----GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQH-HTNSVGAIVVHCSAGVGRTGTFITLDAMLDQ
.|| |.|    .    .|..| | |.     ... | |.||||..|||  ||  .. ...|.|...    .. .| .||||||||||||| |.||  |.|
cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq

AEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQDLY
  .|| .|.   .. .|..| .|||   || |||.|.||  | ||.... | .
lklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_ptpA1_pd Subfamily ptpA1 1550-1742 2.2e-41 137.0 In-house 43-254 (418) alignment 
Range on Protein: 1550-1742
Range on HMM: 43-254/418.0
KKIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGyNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK---
 |  |  |||| ||.  .|.||||  ...   |||.|||.|||  ||...|..|||   .. ||||||||. |  ||||.   |  . ||..|||..   
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

--KMIYGKI---TVTRKSEEV------NTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNS------VGAIVVHCSAGVG
    |||.      |   | |      .     |   . |  . |.. |..|  |||  .| .| |. ...... ... .          |.||||||||
eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGTFITLDAMLD
||||| |   |. 
rtgtfctavimmk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1550-1784 5.9e-27 89.2 In-house 39-276 (312) alignment 
Range on Protein: 1550-1784
Range on HMM: 39-276/312.0
KKIENKQKNRYINIIAYDHSRVQLPLLENdphsDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK---
  .  |. ||| ||  .|  |  |   ||     |. |||.     | |....|||   ..  ||...    .  |..|.  ||    || ||  |    
aflkfkdlnrypniqcwdrgrftlagden....fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf

-----KMIYG----KITVTRKSEEVNTHYTVRTFSVVFGDNiREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTnsvgAIVVHCSAGVGRTGTFITL
     . .|     .| .  || .  ||  ..      |..   . .. ..|||| |.|      . .. .||. .      .. |||||||||||.. .
vdledhrvyteycteieiggkskdkithrvlkvvvkatgqe.sklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahcsagvgrtgtlali

DAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETF
..|.         .| .    .|..| . |.|  || .   ..|| .
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1551-1794 2.6e-81 268.4 In-house 58-301 (319) alignment 
Range on Protein: 1551-1794
Range on HMM: 58-301/319.0
KIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTntvegeKRKCEKYWPDKKMI-
  .|| |||.|||.|.|...|.|  |.    |||.|| |..||  . .|||||||   ...|||||.|| .|  ||.||      | || .||| |  | 
ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

YGKITVTRKSEEVNTHYTVRTFSVVF---GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH--TNSVGAIVVHCSAGVGRTGTFITLDAMLDQA
...  |  .| |    |.|| . .       .||.. |||.  |||.|||.|...|| ... |.  .   |    |||||||||||||..|.||..||. 
eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrm

EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQD
. |. .|||||. ..||.| ..||   ||.||| |||| .. | . .|  
keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvamp
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1551-1698 3.7e-08 26.5 In-house 24-157 (169) alignment 
Range on Protein: 1551-1698
Range on HMM: 24-157/169.0
KIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNAnfidgynyprryiaaqgpnvasvkdfwRMVWEEDCGKIVMLTNTVEGEKRKCE--KYWPDKKM
   |. |||    .|  | ||.|  . .|  |||.||                           ||.|| .   ||.| .| . .    |   |     .
ltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpav

IYGKIT----------VTRKSEEVNTHYTVRTFSVVFGDNIR-EVVQFHYTSWPDMGVPKY
| |.            |. ... |.  . |      . |..  ..  .||..||. |||. 
ilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqs
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1551-1698 4.7e-08 26.0 In-house 23-156 (169) alignment 
Range on Protein: 1551-1698
Range on HMM: 23-156/169.0
KIENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNAnfidgynyprryiaaqgpnvasvkdfwRMVWEEDCGKIVMLTNTVEGEKRKCE--KYWPDKKM
   |. |||    .|  | ||.|  . .|  |||.||                           ||.|| .   ||.| .| . .    |   |     .
ltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpav

IYGKITV------TRKSE----EVNTHYTVRTFSVVFGDNIRE-VVQFHYTSWPDMGVPKY
| |.         | | .     |.  . |      . |.. | .  .||..||. |||. 
ilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqs
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1553-1794 7.5e-80 263.5 In-house 24-265 (284) alignment 
Range on Protein: 1553-1794
Range on HMM: 24-265/284.0
ENKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTntvegeKRKCEKYWPDKKMI-YG
.|| |||...|.|.|...|.|  |     |||.|| || ||  . .|||.|||   ...|||||.|| .|  ||.||      | || .||| |  | ..
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

KITVTRKSEEVNTHYTVRTFSVVF---GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH--TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEA
.  |  .| |    |.|| . .       .||.. |||.  |||.|||.|...|| ... |.  .   |    |||||||||||||..|.||..||. . 
rfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmke

ENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGDTSIAQD
|. .|||||. ..||.| ..||   ||.||| |||| .. | . .|  
ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalp
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1553-1782 8.2e-69 226.4 In-house 2-237 (237) alignment 
Range on Protein: 1553-1782
Range on HMM: 2-237/237.0
ENKQKNRYINIIAYDHSRVQLPLLENDphSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD--KKMI
||| |||| ||.||||||| |    ..  |||.||....|..  |..|||||||  .| .|||.|||.| |  |||||  .||.. || ||||.  .   
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGKITVTRKSEEVNTHYTVRTFSVVFG---DNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTV--KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQA
||..||. | .|  . ||||.. ..      ..| . |...||||| |||..|. |. | . .  . .| .  |  ..|||||||||| |. .|||| ||
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
. .. .|.||..  . ..|  ..|. .|| ||....||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN23_pd Subfamily PTPN23 1553-1782 3.7e-55 181.8 In-house 42-278 (288) alignment 
Range on Protein: 1553-1782
Range on HMM: 42-278/288.0
ENKQKNRYINIIAYDHSRVQLPllenDPHSDYVNANFIDGY-NYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD---KKM
 . .|||. .|. |||.||.|     . . ||.|| |. .   .   .||.|.|   .. |||.||.|.    ||||..  | .| |...|||    . .
lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

IYGKITVTRKSEEVNTHYTVRTFSVVFG--DNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHT----NSVGAIVVHCSAGVGRTGTFITLDAMLD
 .|...|| ||..   ..  |.... .   |....|.  ..||||..|||.    |..|.  |.....    .|   .||||||||||||.|  . | . 
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

QAEAENAI-DVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
. |..| . |. . .  .|..|  |||  ||..| |.| ||
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1553-1782 2.2e-45 149.6 In-house 55-281 (290) alignment 
Range on Protein: 1553-1782
Range on HMM: 55-281/290.0
ENKQKNRYINIIAYDHSRVqlpLLENDPHSDYVNANFIDGYNYPrrYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK---MI
 . .|||| ...  | .||   .|..  . ||| ||...| . .  .| .||.  ..| |.|||| .|.   |||| . .|  | |||.|.|.|.   . 
tefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGKITVTRK-SEEVNTHYTVRTFSVVFGDNIREVVQFHY--TSWPDMGVPKYTTPLMNFIRTVKQhhtnSVGAIVVHCSAGVGRTGTFITLDAMLDQAEA
.|.|||.   ... ...   .|.||   |. .| .  |.   ||||  |.. |  |.  .|....      | .|||||||.||||||..... |.    
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilld

ENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
  ..|. . .  .|. |.. |||  ||  . ..||.
Gkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1553-1782 1.6e-41 137.1 In-house 32-257 (267) alignment 
Range on Protein: 1553-1782
Range on HMM: 32-257/267.0
ENKQKNRYINIIAYDHSRVQLPLLENDphsdYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRkceKYWPDK---KMI
.|...||. . . ||..|| |   |..    |.|| ...||.  . .|. |.|   .. ||. .. ....  ||.||.. ... |   ..|| |      
knqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnir...lfwPPkmgqakk

YGKITVTRKSEEVNTHYTVRTFSVVFGDN-IREVVQFHYTSWPDMG-VPKYTTPLMNFIrtVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAE
|  .|| .  |. .  | . |. . | ..  ..|. ..|  |        |  ||.  .   |..  |    .||.||.||||.|||...|..|..|  |
yqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgil..aknqlengnrPlvvacsdGvGrsGtflvidsqlerakte

NAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
.  |...|.  .|. || .|.. |.| .|.. | |
gvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1553-1786 6.4e-41 135.3 In-house 40-279 (307) alignment 
Range on Protein: 1553-1786
Range on HMM: 40-279/307.0
ENKQKNRYINIIAYDHSRVQLPLleNDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPD---KKMI
 | .|||| .. . |..|. . .  .   |||. ||..     |...|.||||  ... .|| |. .|.   ..|| ...|  | |||.|||    .|..
antdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

YGKI----TVTR----KSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQhHTNsvgAIVVHCSAGVGRTGTFITLDAML
.|.     .|.     |    .    | |. |..... | . .. .. ||| |||.     .|.. .|.  .||    .||||||||||.|| ...  . 
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry.dtn...pvvvhcsaGvGrsGtivaislvq

DQA-EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVC
|.  . .|  |. ...  .|..|   .|   || ...  ||| |. 
dkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1553-1781 8.9e-22 71.9 In-house 50-282 (302) alignment 
Range on Protein: 1553-1781
Range on HMM: 50-282/302.0
ENKQKNRYINIIAYDHSRVQLPlleNDpHSDYVNANFIDGYNYPRRYIAAQGPNVASV---KDFWRMVWEEDCGKIVMLTNTVEGEKrKCEKYWP---DK
.| .||.  .. ..|. .|.|.   .    .||||  ..  .  |  | || |.| |.    .|||||..| . ..|.|  . | .|   ....|   ..
knlkknqsedvpildsnlvkle...ae.pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

KMIYGKITV-TRKSEEVN---THYTVRTFSVVFGDNIREVVQfHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLD
   |||. | .|| |...   |.|..  .   . . .   |. . | |..  ||.  . |.. .  | ......   .|.    |.|| |.|.|| . ..
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvy.vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

QAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
. .....  . . .. .|..| ..|. ..|| ..| |||
klqkgkepnikeivksiRsqRpravdslkQyvslyiall
Y_phosphatase Protein-tyrosine phosphatase 1554-1782 7.3e-84 276.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 1554-1782
Range on HMM: 1-235/235.0
NKQKNRYINIIAYDHSRVQLpllENDPH-SDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP---DKKMI
||.|||| .|..||..||.|   ..... |||.|||...||. ....||.|||   ...|||||||.|..  |||||. .| ...||..|||   .... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKITVTRK-SEE-VNTHYTVRTFSVVFGDNI---REVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQA
||.|.|. | .|.  ...||.|....   ..    ||| |.|||.||| |||. ...|...|| |....... | .||||||||||||||..||..|.|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
|||. .||....  .|..|..||| .|||.|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1554-1782 7.3e-84 276.2 In-house 1-235 (235) alignment 
Range on Protein: 1554-1782
Range on HMM: 1-235/235.0
NKQKNRYINIIAYDHSRVQLpllENDPH-SDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP---DKKMI
||.|||| .|..||..||.|   ..... |||.|||...||. ....||.|||   ...|||||||.|..  |||||. .| ...||..|||   .... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKITVTRK-SEE-VNTHYTVRTFSVVFGDNI---REVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQA
||.|.|. | .|.  ...||.|....   ..    ||| |.|||.||| |||. ...|...|| |....... | .||||||||||||||..||..|.|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

EAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
|||. .||....  .|..|..||| .|||.|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 1554-1788 1.8e-51 169.6 In-house 1-175 (182) alignment 
Range on Protein: 1554-1788
Range on HMM: 1-175/182.0
NKQKNRYINIIAYDHSRvqlpllendpHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTntvegekrkCEKYWPDKKmiygki
|. |||| .|. |||||          ..||.|||...|. ...|.||.|||   .| ||.||..|.... ||.||         .| |||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

tvtrkseevnthytvrtfsvvfgdnIREVVQFHYTSWPDMGVPKyTTPLMNFIRTVKQhhtnSVGAIVVHCSAGVGRTGTFITLDAMLDQaeaenAIDVY
                          |...|..|..|||.|||  .  | .||..|..    . |...||||||||||||.. .. |. .      ....
.........................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

NFITGMRQNRIKMVQVAEQYQFIYDALLETFVCGD
. .  .|. | .||.  .||.|...|||| . ...
eavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1554-1785 7.1e-37 121.7 In-house 55-290 (305) alignment 
Range on Protein: 1554-1785
Range on HMM: 55-290/305.0
NKQKNRYINIIAYDHSRVQLpllENDPHSDYVNANFIDGYNYP-RRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP----DKKM
.. |||| .. . |.| |.|   .. . |||. ||..     | .|.|.||||   .. .|| || ..   .|||| .|||  | || .|||    .|. 
aitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

IYGKITVTR----KSEEVNTHYTVRTFSVVF-GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQhhtnSVGAIVVHCSAGVGRTGTFITLDAMLDQ
. . | |      |  | ..   . .. . . ||.   | ....| ||| |||      .... ...     |   ||||||||.||||| .... .|..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyilek

-AEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFV
 ||  ..  . ...  .|..|   .|   || ||.  .|. |.
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1554-1786 7.6e-29 95.5 In-house 35-272 (285) alignment 
Range on Protein: 1554-1786
Range on HMM: 35-272/285.0
NKQKNRYINIIAYDHSRVQLpllENDpHSDYVNANFIDGYN-YPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKK---MI
| . ||| .. . . .|| |   .|    ||. |...         ||..|||   .. |||.|...|    ..||   .||   ||  |.|.|    . 
npdlnryadvrcieetrvvl...knh.drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGK--ITVTRKSEEVNTHYTVRTFSVVFGDN-IREVVQF---HYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSvGAIVVHCSAGVGRTGTFITLDAMLDQ
.||  ||.|   ||  .   . ...|.  ..   | . .   .   |||   |. . |.... . ||.   .    |.|||||||||| ||. .|    .
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidyatir

AEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVC
   .  |.. . .  ||  |.. ||   |. |.|  |.| |. 
imenpniemldivremramrfqavqshmqflflyvvlmeyfig
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1554-1779 5.5e-20 66.7 In-house 18-254 (290) alignment 
Range on Protein: 1554-1779
Range on HMM: 18-254/290.0
NKQKNRYINIIAYDHSRVQLPLLENDPHSDYVNANFIDgYNYPRRYIAAQGPNVAS-------VKDFWRMVWEEDCGKIVMLTNTVEGEKR----KCEKY
...... ...    ..|| |    .   .||. ||..  .    | |. | |  .        ...|| |. .|   ..||| .  | ..      |.||
khemdqRlevpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

WPDK---KMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFH-YTSWPDMGVPKYTTPLMNFIRTVKQHHTnsvgAIVVHCSAGVGRTGTFITLD
 |..   .. .. .||  || | .    .|.  | |.|.    |. . . .| .. |.. |  |.. |..||...|    ...|||  |. |  .. ...
vpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHcvdGiSrsAalaaii

AMLDQ-AEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDA
      || .... . . .  .|..| .... |... |.  .
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdag
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1554-1631 5.2e-06 20.2 In-house 37-119 (347) alignment 
Range on Protein: 1554-1631
Range on HMM: 37-119/347.0
NKQKNRYINIIAYDHSRVQLP-----LLENDPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNT
. .|||  .    | .|| |        . |.   |.||  |   |  . || .| |   .|.|||.||      ..| . . 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1565-1692 2.7e-07 25.0 In-house 4-123 (130) alignment 
Range on Protein: 1565-1692
Range on HMM: 4-123/130.0
AYDHSRVQlpllendpHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTnTVEGEkrkcEKYWPDKKMIY---GKITVTRKSEE
 .. ||.|          .|.||.|.   .  . |. .| |  ..  |||.|. |     .|.|  .|| |    ..|||| . .     .|.||    .
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg.sveee....deywpdsePlewyeediivtltdrd

vnTHYTVRTFSVVFGDNIRE----VVQFHYTSWPD
      ...  .   ... |    .  |. . || 
..efknikasnleiesdlneshqaltmfqisnwps
0044763 (Phosphotyrosine protein) phosphatases II 1566-1783 1.8e-36 120.8 In-house 2-170 (178) alignment 
Range on Protein: 1566-1783
Range on HMM: 2-170/178.0
YDHSRVQLPLLENDPHSDYVNANFIDGYnyprRYIAAQGPnvasvKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKMiygkitvtrkseevnth
.|..|| |. ||. . ||| ||..|...     |.....|      |......|.... ||.||...|. . || .|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

ytvrtfsvvfgdnirevVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQaeaenAIDVYNFITGMRQNRIk
                 .|.... .||.|||  .  ...|.. ..... .. |...|||||||||.||.. .. |. .      ..... |  .|. |  
.................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.

MVQVAEQYQFIYDALLET
.|.  .|....|.  |. 
ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 1576-1782 3.1e-41 136.4 In-house 6-171 (176) alignment 
Range on Protein: 1576-1782
Range on HMM: 6-171/176.0
LENDPHSDYVNANFIDGYnyprRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDkkmiY----Gkitvtrkseevnthytvrtf
|  |...||.|||.|.|.    |.|| ||| . .. ||..|..|.... .|.||. || .. ||  |||.    .                         
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi....................

svvfgdnirevvQFHYTSWPDMGVPKYtTPLMNFIRTVKQHHTNSvGAIVVHCSAGVGRTGTFITLDAMLDqaeaENAIDVYNFITGMRQNRI-KMVQVA
            |.... |||.||| . . |..... .... ..  | ..||||||.|||||.. .. .      |. ..|.. .  .|. |  ..||  
............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtp

EQYQFIYDALLE
|||.|.|...|.
eQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 1579-1777 3.6e-41 136.1 In-house 2-154 (172) alignment 
Range on Protein: 1579-1777
Range on HMM: 2-154/172.0
DPHSDYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTvegekrkcekywpdkkmiygkitvtrkseevnthytvrtfSVVFGDN
|..|||.||...|.|  |.|.|| |||    . |||||..|.... ||.||.                                          .   . 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpell

IREVVQFHYTSWPDMGVPkYTTPLMNFIRTVKQ-HHTNSVGAIVVHCSAGVGRTGTFITLDAMLdqaeaeNAIDVYNFITGMRQNRIKMVQVAEQYQFIY
 |...|..|..|||.|||  .  |..|.. ... .. .. |...||||||||||||.. .. ||        ..... .  .|. | ..||  .||.|.|
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 1580-1784 6.7e-52 172.1 In-house 2-225 (272) alignment 
Range on Protein: 1580-1784
Range on HMM: 2-225/272.0
PHSDYVNANFIDGYNY---PRRYIAAQGPNVASVKDFWRMvWEEDCGKIVMLTNTVEGEKRKCEKYWP-------------DKKMIYGKITVTRKSEEVN
| |.|.||....||..   |.|.....||  ....||||. .|...  ||.|....| .. ||..|||             .  . ||...||  |||. 
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

THYTVRTFSVV---FGDNIREVVQFHYTSWPDMGVPKytTPLMNFIRTVKQhhtnsVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAID--------V
..|..|.. ..     ...||| ..|||.|||.|||.   .| .... . .      |...||||||..||||.. |. .| . ..|  .|        .
ldyilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

YNFITGMRQNRIKMVQVAEQYQFIYDALLETF
....  .|. | ..||  |||.|.|.|||| .
eeaveelraqrpgavqteeqylflyeallell
0051082 (Phosphotyrosine protein) phosphatases II 1580-1781 1.4e-34 114.3 In-house 1-150 (151) alignment 
Range on Protein: 1580-1781
Range on HMM: 1-150/151.0
PHSDYVNANFIDGYnyprrYIAAQGPnvasVKDFWRMVWEEDCGKIVMLTNTVEGEkrKCEKYWPDKKmiygkitvtrkseevnthytvrtfsvvfgdni
|.||| |.....|.     ... .||      ||.....|...  ||.|....| .  .| .|.|.                                  
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

REVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQhhtNSVGAIVVHCSAGVGRTGTFITLDAMLDQaeaenaIDVYNFITGMRQNRIKMVQVAEQYQFIYDA
.||.......||| |.| ..  ...|.. . .   .. | ..||||||.|||||.. |. || .      ....  .  .|. |  .||  .|..|.. |
ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa

LL
||
ll
0036282 (Phosphotyrosine protein) phosphatases II 1582-1778 6.6e-47 154.8 In-house 2-164 (174) alignment 
Range on Protein: 1582-1778
Range on HMM: 2-164/174.0
SDYVNANFIDGYNYPRRYIAAQGPNVasvkdFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDkkmiygkitvtrkseevnthytvrtfsvVFGDNIRE
||| ||...|..  ..|.|| |||       ||.|..|...  .|||.. .| .. ||  |||.                               |  |.
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe............................lredlerl

VVQFHYTSWPDMGVPKYTTpLMNFIRTVKQHHTN-SVGAIVVHCSAGVGRTGTFITLDAMLDQAEaENAIDVYNFITGMRQNRIKMVQVAEQYQFIYD
..|..|. |||.|||  .. | .|.. |.... . . | ..||||||||||||.. .. || . . |...|.....  .|. | .|||  .||.|.|.
giqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1583-1774 1e-31 104.8 In-house 76-271 (301) alignment 
Range on Protein: 1583-1774
Range on HMM: 76-271/301.0
DYVNANFIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK---KMIYGK--ITVTRKSEEVNTHYTVRTFSVVFGD
  . ||.|.    |.|.||.|||  .. .||| |.   |  |||||...|| ...|||.| | |   |.  |.  |... |   .| . . ||. |.   
vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedst

---NIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQhhtnSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQ
   . | |. . |..|.| ||||  . |....  ||.    |   ||||||||.||. .||. . .  . ||.. |.. . .  .|..| . ||  .|  
gkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
0049260 (Phosphotyrosine protein) phosphatases II 1589-1778 2.9e-40 132.8 In-house 1-144 (152) alignment 
Range on Protein: 1589-1778
Range on HMM: 1-144/152.0
FIDGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWpdkkmiygkitvtrkseevnthytvrtfsvvfgdnirevvQFHYT
|||||..|...||.|||   ...|||||..| ... |||||. .|  | |||.|.                                        |....
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi........................................qylhl

SWPDMGVPKYTTPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLdqaeaeNAIDVYNFITGMRQNRIKMVQVAEQYQFIYD
 |||.|||. .  |. ... ....  .. | ..||||||||||||.. .. ||      . .......  .|. | ..|.  .|..|.|.
pwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1591-1685 3.2e-10 33.9 In-house 230-323 (440) alignment 
Range on Protein: 1591-1685
Range on HMM: 230-323/440.0
DGYNYPRRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTvegEKRKCEKYWPD--KKMIYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQF
.||     .||.| |  ..| ||||.| .     |.|| .    . . |  |||   . . .| .||  |  |      |||. . . ... |. ||
egyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqf
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1594-1781 4.1e-08 26.2 In-house 112-306 (346) alignment 
Range on Protein: 1594-1781
Range on HMM: 112-306/346.0
NYPRRYIAAQGP---NVASVKDFWRMVWEEDCgKIVMLTNTVEGEKRKCEKYWPDKKMIY---GKITVTRKSEEVNTHYTVRTFSVVFGDNIREVV-Q-F
.. .. | || |   | . |.||| |...|.  ..| |    .  |      . |..  |   ||. .  .  .|       |  |.   |   |. |  
qfehklivaqlpqmenesfvedfwymiyqeqi.hlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvh

HYTSWPDMGVPKYTTPLMNFIRTVKQH-HTNSVGAIVVhCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
|.. |  .  |  | |....|   .     ...|  ||    | ||. .||     ..| .     .... .  ..|.|   |.   ||  ||  ..
hhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivf
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1597-1778 1.5e-23 78.1 In-house 4-197 (198) alignment 
Range on Protein: 1597-1778
Range on HMM: 4-197/198.0
RRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKM---IYGKITVTRKSEEVNTHYTVRTFS----VVFGDNIREVVQFHYTS
|||||.| |   .. |||.||||   |.|||. .     .     |||  .     || ..|| |.  ..  ||. ..     .      ||. .. .||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDMGVPKYTTpLMNFI---RTV-KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAE--NAIDVYNFITGMRQNRIKMVQVAEQYQFIYD
| .   |. .  .. |.   | | |..  .    ..|||| | | || |..||  .   |      .|...    .|| |  ..   ..|.|||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1597-1778 1.6e-23 77.9 In-house 5-198 (199) alignment 
Range on Protein: 1597-1778
Range on HMM: 5-198/199.0
RRYIAAQGPNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDKKM---IYGKITVTRKSEEVNTHYTVRTFS----VVFGDNIREVVQFHYTS
|||||.| |   .. |||.||||   |.|||. .     .     |||  .     || ..|| |.  ..  ||. ..     .      ||. .. .||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDMGVPKYTTpLMNFI---RTV-KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAE--NAIDVYNFITGMRQNRIKMVQVAEQYQFIYD
| .   |. .  .. |.   | | |..  .    ..|||| | | || |..||  .   |      .|...    .|| |  ..   ..|.|||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1605-1776 6.4e-20 65.8 In-house 99-280 (302) alignment 
Range on Protein: 1605-1776
Range on HMM: 99-280/302.0
PNVASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWPDK---KMIYGKITVTRKSEEVNT-HY----TVRTFSVVF-----GDNIREVV-QFHYTSW
|   ... .| .. . . . .| |.. ||.|..|| .|. ||   .. .|. ||. .| . .  ..    ... ..| .      .. .  |  .....|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDMGVPKYTTPLMNFIRTVKQHHTNsvgaIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFI
|| | || . . .. ..  . . .|    ..||||||||||||....   ..    ..  |. . .. .|| |   || ..|  ..
pdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 1607-1781 1.2e-14 48.9 In-house 44-224 (263) alignment 
Range on Protein: 1607-1781
Range on HMM: 44-224/263.0
VASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP---DKKMIYGKITVTRKSEEVNTHYTVRTFSVVFG--DNIREVVQFHYTSWPDMGVPKYTTP
|  .. |....      ..|||..  | .. ||..|.|   |.|... ...|.      ..    . .  ..|   ....| .. |. |..   |. .  
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

LMNFIRTVKqhhtNSvGAIVVHCSAGVGRTGTFITLDAMLD-------QAEAeNAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
 .| .. ..    ||   .|||||.|.||.  |   . .         ....   .|  .... .|..| . ..   |  |    .|
ilnilkvar....ns.kslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtPmqLafsilmvL
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1608-1781 7.2e-18 59.6 In-house 39-218 (255) alignment 
Range on Protein: 1608-1781
Range on HMM: 39-218/255.0
ASVKDFWRMVWEEDCGKIVMLTNTVEGEKRKCEKYWP---DKKMIYGKITVTRKSEEVNTHYTVRTFSVVFG--DNIREVVQFHYTSWPDMGVPKYTTPL
 .|. |....   .  ..|||..  | .. ||..|.|   |.|... ...||      .     ..    .|   . ..|  ..|. |..   |. .  .
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

MNFIRTVKqhhtNSvGAIVVHCSAGVGRTGTFITLDAMLD-------QAEAeNAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALL
.| .. |.    .|  ..|||||.|.||. .|.  . .         ..|.   .|  .... .|..| . ..   |  |    .|
lnilkvvr....ds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtPlqlafsilmvl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1636-1783 3.6e-06 20.7 In-house 147-301 (332) alignment 
Range on Protein: 1636-1783
Range on HMM: 147-301/332.0
KRKCEKYWPDKKM--IYGKITVTRKSEEVNTHYTVRTFSVVFGDNIREVVQFHYTSWPDMG-VPKYTTPL-----MNFIRTVKQHhTNSVGAIVVHCSAG
 . | |.||.|.    .  ...    .  .||     ..|    . .. | .|.  | |   .|.|   .     ...||. |.     .| |.. |..|
akicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskkt.gvcigpimlvcatg

VGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
| .   . |.| .. .   |  . . . .. .. .|.  ..    |    . |.. 
vekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1662-1784 3.2e-18 60.6 In-house 198-344 (350) alignment 
Range on Protein: 1662-1784
Range on HMM: 198-344/350.0
VNTHYTVRTFSVVFGDNIReVVQFHYTSWPDMG---VPKYTTPLMN----FIRT--VKQHHTNS-VGAIVVHCSAGVGRTGTFITLDAMLD-------QA
.. ....    .   |    | |...  |.|..    |.   . ..    .| .   ..|  |.   .|.||||||||||||..||| .|          
lkdnnsltaitlaasdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenlt

EAENAIDVYN--------FITGMRQNRIKMVQVAEQYQFIYDALLETF
.  . .|| .         .  .|. ||.|||  .|. |||.|||  |
kesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
0048076 (Phosphotyrosine protein) phosphatases II 1663-1781 2.3e-25 84.4 In-house 26-140 (145) alignment 
Range on Protein: 1663-1781
Range on HMM: 26-140/145.0
N--THYTVRTFSVVFGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSvGAIVVHCSAGVGRTGTFITLDAMLDqaeaENaIDVYNFITGMR
    ..|| ...  . .  |...|..|..|||.|||  .  |..|.. ..... .  | ..||||||||||||.. .. ||     .. ..... .  .|
kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvr

QNRIKMVQVAEQYQFIYDALL
. | ..|.  .|..|.|...|
sqrpgavpnpgqlrflyefel
subfamily_PTPDC1_pd Subfamily PTPDC1 1671-1777 1e-09 33.1 In-house 71-169 (182) alignment 
Range on Protein: 1671-1777
Range on HMM: 71-169/182.0
FSVVFGDNIREVVQFHYTSWPDMGVPKYTTpLMNFIRTVKQHHTNSvgAIVVHCSAGVGRTGTFITLDAMLDQ-AEAENAIDVynfitgMRQNRIKMVQV
||  . .  .. . ..  .|.| ||.  .. ... .. |..  ..   .. ||| || ||||  |.   .  .  .||.||..      .|..| | .| 
fsYdlealmeqgiyvynfgwkDygvasler.iLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaikl......vrskrpksiqt

AEQYQFIY
 || ... 
reqvelvk
0048179 (Phosphotyrosine protein) phosphatases II 1675-1778 4.4e-24 80.2 In-house 42-139 (144) alignment 
Range on Protein: 1675-1778
Range on HMM: 42-139/144.0
FGDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSvGAIVVHCSAGVGRTGTFITLDAMLdqaeaENAIDVYNFITGMRQNRIKMVQVAEQYQ
  . .||..|.....|||.||| ... | .|.. ..... .. | ..||||||||||||..... |.     .. ..... .  .|. |  .|.  .|..
pefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlr

FIYD
|...
fLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1676-1820 9.8e-35 114.7 In-house 85-230 (440) alignment 
Range on Protein: 1676-1820
Range on HMM: 85-230/440.0
GDNIREVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHH-TNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQ
| . | . |.|| .||| ||||.. |....|. |.. .   . | ..||||||.||||  |..|..| .|.  . ||...||  ||.|| .|||. ||| 
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FIYDALLETFVCGDTSIAQDLYLQRYPSLLAPSPDTGSTLLQEQFE
|...|.|| ..|||| | .|   .|   .  |.| |  . ||..||
fvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
0048567 (Phosphotyrosine protein) phosphatases II 1677-1768 2e-06 22.2 In-house 25-126 (157) alignment 
Range on Protein: 1677-1768
Range on HMM: 25-126/157.0
DNIREVVQF-------HYTSWPDMGvPKYTTPLMNFIRTVKQHH---TNSVGAIVVHCSAGV---GRTGTFITLDAMLDQAEaeNAIDVYNFITGMRQNR
... ....|       ... . | | |   . |..||. ...     ..  .||.|||.||    |||.|.| . ..| .    .. ......  .|.. 
kslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf..tpeeaiaplrivrpgs

IKMVQ
.   .
vpfrd
0038934 (Phosphotyrosine protein) phosphatases II 1681-1775 1.9e-09 32.9 In-house 78-171 (194) alignment 
Range on Protein: 1681-1775
Range on HMM: 78-171/194.0
EVVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSV-GAIVVHCSAGVGRTGTFITLDAML-DQAEAENAIDvynFITGMRQNRIKMVQVAEQYQF
  ....   .|| |..  .  |..|.. |.... ..  |...||| ||.|||||..    .   .  || ||.   ... .|.. |  ..  |... 
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAia...lfrekRpgaipnqdyleallk
PTPc_DSPc_SM00012 1682-1782 2.1e-34 113.2 In-house 2-105 (105) alignment 
Range on Protein: 1682-1782
Range on HMM: 2-105/105.0
VVQFHYTSWPDMGVPKYTTPLMNFIRTVKQHHTNSV--GAIVVHCSAGVGRTGTFITLDAMLDQAEAE-NAIDVYNFITGMRQNRIKMVQVAEQYQFIYD
| ..|||.|||.|||..........| ||.....|   . .||||||||||||||..|| .|.| |.| . .|.....  .|. | .|||  |||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
PTEN_1 1682-1735 3.5e-06 22.0 In-house 94-148 (196) alignment 
Range on Protein: 1682-1735
Range on HMM: 94-148/196.0
VVQFHYTSWPDMGVPKYTtPLMNFIRTVKQHHT--NSVGAIVVHCSAGVGRTGTFI
 |...  ...| |.|     |. ... ...     .. ....||| ||.||.|| .
gveylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
PTPc_motif_SM00404 1696-1766 2.4e-06 22.5 In-house 63-123 (140) alignment 
Range on Protein: 1696-1766
Range on HMM: 63-123/140.0
PKYTTPLMNFIRTVkqhhTNSVGAIVVHCSAGVGRTGTFITLDAMldQAEAENAIDVYNFItgmRQNRiKM
 ||   ...||...    ... |...||| ||| |..|.|.   |  . .  .. ..|.|.   ...| ..
skyldkvldfiena....ekkggkvlVHCqaGvSRSatliiaYlm..ryrqlslaeayefv...kerR.pi
subfamily_CDC14_pd Subfamily CDC14 1700-1740 2.1e-06 21.8 In-house 246-286 (328) alignment 
Range on Protein: 1700-1740
Range on HMM: 246-286/328.0
TPLMNFIRTVKQHHTNSVGAIVVHCSAGVGRTGTFITLDAM
||  . ..   .   .. |||.||| ||.|||||.|.   |
tPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylm
subfamily_PTEN_pd Subfamily PTEN 1702-1777 9.6e-07 24.0 In-house 98-173 (184) alignment 
Range on Protein: 1702-1777
Range on HMM: 98-173/184.0
LMNFIRTVKQHHT-NSVGAIVVHCSAGVGRTGTFITLdAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIY
| .........   ..   .|||| || ||||. |.   .| .   |.| .. .. . .| .  | |..  |  ...
leeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYve
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1709-1782 1.3e-12 42.2 In-house 221-293 (297) alignment 
Range on Protein: 1709-1782
Range on HMM: 221-293/297.0
VKQHHTNSVgAIVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLE
.. ..  ..  ..|||||||||.|  .  |..|..   .   ||  ... .|..| ..||  ||....||| |.
lraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 1710-1780 1.7e-15 51.5 In-house 240-311 (319) alignment 
Range on Protein: 1710-1780
Range on HMM: 240-311/319.0
KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLDQAEAE-NAIDVYNFITGMRQNRIKMVQVAEQYQFIYDAL
.  . .| | .||||| ||||||. |. |  . . |   ...|. . .  .|..| . |.  |||.|||  |
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_eak_pd Subfamily eak 1710-1783 1.9e-09 31.4 In-house 229-304 (332) alignment 
Range on Protein: 1710-1783
Range on HMM: 229-304/332.0
KQHHTNSVGAIVVHCSAGVGRTGTFITLDAMLD--QAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLET
| .||    | .. .. |  |.|.|. .| ..   ..  .|.  | ..|  ... ||. | || |. |||...|. 
kyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1711-1784 2.1e-13 44.3 In-house 259-344 (349) alignment 
Range on Protein: 1711-1784
Range on HMM: 259-344/349.0
QHHTNSVGAIVVHCSAGVGRTGTFITLDAMLD----QAEAENAIDVYNF--------ITGMRQNRIKMVQVAEQYQFIYDALLETF
  .|. . ...|||||| ||||...||| .|.      .  | |.. .         .  .|. || |||   |. .||.|||. |
yldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1720-1785 6.6e-15 49.3 In-house 1-66 (69) alignment 
Range on Protein: 1720-1785
Range on HMM: 1-66/69.0
IVVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFV
.|||||.| |||||||..   . .  .|  .|..| .  ||. |  ||    .| ||.||| |.. 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1721-1787 1e-14 48.6 In-house 1-67 (69) alignment 
Range on Protein: 1721-1787
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTFITLDAMLDQAEAENAIDVYNFITGMRQNRIKMVQVAEQYQFIYDALLETFVCG
|||||.| |||||||..   . .  .|  .|..| .  ||. |  ||   ..| ||.||| |..  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1791-2085 6.4e-71 234.0 In-house 5-296 (298) alignment 
Range on Protein: 1791-2085
Range on HMM: 5-296/298.0
IAQDLYLQRYPSLLAPSPDTGSTLLQEQFERLDMFTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDMFLGT
| .. . .  . | | ..... | ....|.||.  . . ...| . ||.. | .|||| | .. |.||  | . . .. ..||||||| .|.... |. |
ieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiat

QTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQ-SMAEYWPDESESevTFGPFTITLIDEEHYDEISCRTMELRSTTSKsRVQTVYQLQLTTWPITsEI
|.||..|| ||||.| ...|.||.||. |  .|.  . .||||| .   |.| .|..|  .|.. .. .|.... ..... . ..| ||. |.||    .
qaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdk.gv

CASAISFMELHRRAMVwNEANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYDIY
 . | | ..| |.    .. .|...|..|.| .| | .|||. ..|||||.. |. |||||. |..|. | ||| . .|| ||...   .|||.. .
penatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
0051299 (Phosphotyrosine protein) phosphatases II 1797-2079 1.3e-68 226.9 In-house 11-286 (288) alignment 
Range on Protein: 1797-2079
Range on HMM: 11-286/288.0
LQRYPSLLapspDTGSTLLQEQFERLDMFTIKprdDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE-NGTNYINASFLPGYTKKDMFLGTQTPLPN
|...  ||     .| |.|.|.||.|  ....    .|..|.   |..|||| | || |.|| .| .. . .|..|||||...|| .|  |. ||.||||
lklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TVGDFWRLVFDYKISTIIMLNGLASKD-QSMAEYWPDesESEVTFGPFTITLIDEEHYDEISCRTMELRSTT---SKSRVQTVYQLQLTTWPiTSEICAS
||.||||.|.......|.||..|  .. . .| |||.  .. .|.|..|.||..||..|.. .||.|.. ..    .. ..||.... |.||    .  |
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpds

AISFMELHRRAMVWNEanAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
. ..... |... ...  ... |..|||..| | ||||. |  .||.|. |. |||..| ||.|  | |.| .. ||.|.. .|  ||
pellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1801-2087 3e-56 185.5 In-house 8-286 (287) alignment 
Range on Protein: 1801-2087
Range on HMM: 8-286/287.0
PSLLAPSPDTGSTLLQEQFERLDMFTikPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLItevENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDF
  . |  ...|..  ..||  |.  |   |.||.  .  | | .|||... |. |. |  |    ..  .||||.|. || .|  |. ...|. ||. .|
gefvakghakgnegfknqftvleqvt..qredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnf

WRLVFDYKISTIIMLNGLASKDQSM-AEYWPDESEseVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPITSEICASAISFMELH
|.|. | ....|.||  .  .|...  .|||.|.   |..|...|.|..||....   |..|.. .....  |.| | |.|.|. | ..   . ... ..
WkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

RraMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYDIYEN
.  |. ..    ...|.||| |. | ...||.    ... . |  .||||  |. |  . |.|   .||.||  ..  ||||...| .
e..myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1803-1984 4.4e-19 63.0 In-house 57-232 (244) alignment 
Range on Protein: 1803-1984
Range on HMM: 57-232/244.0
LLAPSPDTGSTLLQEQFERLDMFTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLiTEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWR
.|. |   ||  .. .. .     |.|    .. | |  | .|||    || | .|  | ..   |  ||||||.    .   .. || || .|  |||.
ilssskkegsdyinanyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvpl.skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwk

LVFDYKISTIIMLNGLASKDqsmaEYWPDESESEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRvQTVYQLQLTTWPI
.... ..  ...|  .  .|    |||||    |      |.|| | . . .| .  .|. |   .|  |..  .|.. || 
mmlerhvnvlvvlgsveeed....eywpdseplewyeeditvtltdrdefknikasnleiesdmnesh.qaltmfqisnwps
0045450 (Phosphotyrosine protein) phosphatases II 1807-2079 1.5e-64 214.0 In-house 21-304 (307) alignment 
Range on Protein: 1807-2079
Range on HMM: 21-304/307.0
SPDTGSTLLQEQFERLDMFTIKPrDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE--NGTNYINASFL--------PGYTKKDMFLGTQTPLPNT
 . .. |.|...||.|  .|...  .| ..|.   | .|||| | || | .| .| .. .  ....|||||.         .|| .|. |. ||.|||.|
llldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpet

VGDFWRLVFDYKISTIIMLNGLASKDQ-SMAEYWPDEsESEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPiTSEICASAISF
| ||||.........|.||..|  ...   |.||||| ..|.|.|.||.||..|||.|.. .||.|.  .  .. . ||.... |.||    .. |  ..
vedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp.dhgvppsfeel

MELHRRAMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKL---VDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
 .. .... ..|.. |. |..|||..| | ||||. .  .|..|. |.    ||...| |..|. | ||| .. ||.|.. .|. .|
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0050432 (Phosphotyrosine protein) phosphatases II 1809-2085 1.7e-70 233.2 In-house 38-305 (308) alignment 
Range on Protein: 1809-2085
Range on HMM: 38-305/308.0
DTGSTLLQEQFERLDMFTIkprDDELRTARNSMNVHKNRYHDKLPTDKSRPYLitevENGTNYINASFLPGY--TKKDMFLGTQTPLPNTVGDFWRLVFD
 ....||.|.||.| ....   . | ..|.   |..|||| | || |.|| .|    ..|..|||||. .||   ..  |. || ||||||.||||.|..
aldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

YKISTIIMLNGLASKD-QSMAEYWPDESE-SEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKsRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMV
.....|.||. |  .. . .|.|||.| . . ...|.||.||..||..|.. .||.||. . ..  . ||.... |.||    .. |. ..... ...  
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWp.dhgvPpspeilldflelvrk

WNeanaKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYDIY
..    .. ||.|||..| | ||||. |  .||.|. |. ||||.| |..|  | |.| .. ||.|.. .|  || .. ..
sl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
subfamily_PTPN6_pd Subfamily PTPN6 1809-2081 2e-45 150.1 In-house 22-299 (306) alignment 
Range on Protein: 1809-2081
Range on HMM: 22-299/306.0
DTGSTLLQEQFERLDMFTIKPRDDElRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENGTNYINASFLPGY--TKKDMFLGTQTPLPNTVGDFWRLVFD
... . ..|.||.|.    | . .  . ..   | .||||.  || |..|  |  .   |..||||... .   ...  .. ||  |..|| ||||.|..
slekagfeeefeelqqeeakkllsr.kegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

YKISTIIMLNGLASKDQ-SMAEYWPDESESEVtFGPFTITLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPITSEICAS--AISFME-LHRRA
 .   |.|.     . .   | |||||.|.|  .|  ..| ..|.. ..   |.. .  ...|.. ..|.|.. ..||  .        ..|.| ..|..
ensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkq

MVWNEAnaKDAPIMVHCKDGEGATGTFCSLSSVLERLNV---EKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDS
   .||  .  ||.||| .| | ||||  .  .|. ..    .  .|. .. | ||. | | |   .|| |.. ... |...
eeleea..eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1809-2082 1.6e-20 67.9 In-house 20-293 (305) alignment 
Range on Protein: 1809-2082
Range on HMM: 20-293/305.0
DTGSTLLQEQFERLDMFTIKPRDDELRTARNSM--NVHKNRYHDKLPTDKSRpYLITEVEnGTNYINASFLPGY-TKKDMFLGTQTPLPNTVGDFWRLVF
| |   |.|.| .|  .|     . .  | .|   .. ||||.|    |.|   .. .    ..|| | ..      .  |. .| || .|. .|| .| 
dvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsa.vkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmvi

DYKISTIIMLNG-LASKDQSMAEYWPDESESEVTF-GPFTITLID-E---EHYDEISCRTmeLRSTTSKSRVQTVYQLQLTTWPITSeICASAISFMELH
. |.  |.||   .       |.|||      ... .   .  .      |   ||   .  |. | | ..  .| .|| | ||    .    .. .|| 
qnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitl..lnltysgdqkmsvrhlqwtewpdrg.vppckltslell

RrAMvwneaNAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVD-VFQACKRVRAIRRGAVASLAQYEFIHSVLRLY-LDSY
  |.          ||.|||  | | |||  ..  .||..  .| .  . .  | .|  |  .. .  || ||| |.  | |. |
s.ai.....rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
0047943 (Phosphotyrosine protein) phosphatases II 1810-2079 7.5e-68 224.3 In-house 9-272 (273) alignment 
Range on Protein: 1810-2079
Range on HMM: 9-272/273.0
TGSTLLQEQFERLDMFTIkprDDELRTARNSMNVHKNRYHDKLPTDKSRPYLiteVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKI
.|.|||.|.||.|  ...   . . ..|.   | .||||.| || |.|| .|    ..|..|||||...|| .|  |. ||.||||||.||||.|.....
lgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

STIIMLNGLASKDQ-SMAEYWPDESES-EVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSrVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNE
..|.||. | ....   | |||.| .. ..|.|.||.||..||..| .  ||.||... ..  . ||.... |.||    ...|  |..|. . .. ..|
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwp.dhgvppslesllefielvrkale

ANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
|. .. |..|||..| | ||||. |  .|..|. |. |||..| |..|  | |.| .. ||.|.. .|  ||
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 1810-2086 1.7e-66 219.9 In-house 10-284 (297) alignment 
Range on Protein: 1810-2086
Range on HMM: 10-284/297.0
TGSTLLQEQFERLDMFTIkprDDELRTARNSMNVHKNRYHDKLPTDKSRPYLiteVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKI
....||...||.|. . .   . .|..|..  |..||||.| || |..| .|    ..|..|||||...||  |  |. ||.||||||.||||.|.....
lflalllkefeellplll...lgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

STIIMLNGLASKDQ-SMAEYWPDESESEVTFGPFTITLIDEEH--YDEISCRTMELRSTtSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWN
..|.||. | ...    |.|||.| ....|.|.||.||...|.  .|..  ||.|.  |  .. . ||.... |.||    .  |. |.... ...  ..
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwp.dhgvpespaslldfielvrkvl

EANAKDAPIMVHCKDGEGATGTFCSLSSVLERLN---VEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYDIYE
..  .. |..|||..| | .|||. .  .|..|.    |. ||...| | .|  | ||| .| ||.|.. .|  .| .....|
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
0039614 (Phosphotyrosine protein) phosphatases II 1810-2081 1.4e-64 213.7 In-house 29-291 (297) alignment 
Range on Protein: 1810-2081
Range on HMM: 29-291/297.0
TGSTLLQEQFERLDMFTIkprdDeLRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE--NGTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFD
...|||...||.|  ...    |  ..|.   |..|||| | || | || .| .| .  ....|||||...|| . .. |. ||.|||.||.||||.|..
nsktllllefeellslkp....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

YKISTIIMLNGLASKDQSMAEYWPDESEsevTFGPFTITLIDEEHYDEISCRTMELRStTSKSrvQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWN
.....|.||. |  ...  |.|||.|..   |.|.||.||...||.| .  ||.|..  ...|   ||...| | ||    .. |. ...|. . .. ..
qgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn.nges..rtvthfqytgwp.dhgvppslellleflelvreal

EANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDS
... |. |. |||..| | ||||. .  .||.|. |. |||..| |..|  |.||| .. ||.|.. .|. .|  
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1810-2083 1e-59 197.2 In-house 20-287 (319) alignment 
Range on Protein: 1810-2083
Range on HMM: 20-287/319.0
TGSTLLQEQFERLDmftiKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYK
||.|||...|. |.    .. .|....| .  | .||||.. |. |..|  | . .  .|..||||||. || ... |. ||.|| ||. ||||.|....
tgetllekefkllk....eavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeee

ISTIIMLNGLASKDQ-SMAEYWPDESesEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVwNE
.|...||..|. | .  . .|||.|    ...| ...|| .||. ...  | ..|.  .|.    .| . | | ||   ..  .| | ..| .|      
ssivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWp.dhdvPekatslldllkrirk.sr

ANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYD
 . .. ||.||| .| | ||||. |. .|||.. | ..|||.  .|.|. |   |   .||.||. .|. .....|
ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0043336 (Phosphotyrosine protein) phosphatases II 1810-2078 4e-59 195.7 In-house 17-276 (278) alignment 
Range on Protein: 1810-2078
Range on HMM: 17-276/278.0
TGSTLLQEQFERLDMFTIkprdDELRTARNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYK
.. |||...||.|. |..    |. ..|.   |..|||| | || | || .|   . .....|||||...|| ... |. ||.|||.||.||||.|....
nlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

ISTIIMLNGLASKD-QSMAEYWPdesESEVTFGPFTITLIDEEHYDEISCRTMELRStTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNE
..||.||..|  .. .  |.|||   .. .|.|.||.||..|||.| .  ||.|.   . .. ..||.... . ||   ... |  ..... .... ..|
vttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwp.dhgvpeslsllldflkavreale

anAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLY
   .. |..|||..| | ||||. |  .||.|. |. ||...| |..|  | ||| .. ||.|.. .|. |
..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPRG_pd Subfamily PTPRG 1811-2077 6.6e-56 184.7 In-house 17-285 (563) alignment 
Range on Protein: 1811-2077
Range on HMM: 17-285/563.0
GSTLLQEQFERLDMFTiKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE--NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYK
| . ..|.|| | . | ...| .  ....  | .|||| . .. |.||  |    .  .  .||||... || |.. |..|| ||..|. ||||.... .
gdigfseefealqset.iskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

ISTIIMLNGLASKD-QSMAEYWPDesESEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRV-----QTVYQLQLTTWPITSEICASAISFMELHRRa
 ..|.|.  |  .  .    |||   .  .|.| ...|||.||.    . ||. .. .  |        ..|.| . |.|| ..    |.   .  ... 
vaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.

mvwNEANAK-DAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRL
   . || .   ||.|||. | | |||.. |...|.... |. |.||.  |..|| |   |..  || |.| .|  
...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1811-2085 1.6e-53 176.4 In-house 18-289 (290) alignment 
Range on Protein: 1811-2085
Range on HMM: 18-289/290.0
GSTLLQEQFERLDMftiKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVEN---GTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDY
| .  ..||..||      .. .  ..  | | ..||... ...|  |  |    ..     .||||... || .|  .. ||.|..||. |||.|. . 
gnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

KISTIIMLNGLASKDQ-SMAEYWPDEsESEVtFGPFTITLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPITSEICASAISFMELHRraMVWN
|.. |.||    ....     ||||. ...  .|.|.|.|..||...|.  |..|.....|. . |.| |.|.|.|. | .. . . . . ...  |. .
kvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillviee..mykt

EANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYDIY
.    . .|.||| |. | ...||..   ... . |  .||||  |. |  . | | .  ||..|....  ||||.. |
qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_PTPN23_pd Subfamily PTPN23 1811-2074 1.8e-42 140.1 In-house 13-275 (288) alignment 
Range on Protein: 1811-2074
Range on HMM: 13-275/288.0
GSTLLQEQFERLDMFTIKPrDDELRTARNSMNVHKNRYHDKLPTDKSRPYLItevENGTNYINASFLPGYTKK-DMFLGTQTPLPNTVGDFWRLVFDYKI
| | |...|. |..   |    .  .|   ....|||..| || |..|  |    ..  .||||||. . .     |. ||.||..|..|||..|.. | 
gktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

STIIMLNGLAS-KDQSMAEYWPDESESEVTFGPFTITLIDEEHYDEISCRTMELRsTTSKSRVQTVYQLQLTTWPITsEICASAISFMELHRRAMV--WN
|.|.||   .  .......||| . .  |.||....|| .... .. . |...|. | ....|..|  ||||.||    . ||  .....   .     .
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkle.tldadavksvshlqltsWpel.GvPasPetllqfldevesayea

EANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVE-KLVDVFQACKRVRAIRRGAVASLAQYEFIHSV
. .  ..|..|||  | | ||.|. . .... |...  |.|. |  .|.|. ||  |   .|..|  ..
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyea
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1812-2079 1.4e-49 163.6 In-house 17-276 (515) alignment 
Range on Protein: 1812-2079
Range on HMM: 17-276/515.0
STLLQEQFERLDMFTIKPRddelRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIS
 ||. |.|  |    | |.      |.. .| .||||.. || |..|  | . . .   .|.|||..|..     .. .|.|.. .| ||||||......
ttlfseefhdlpgpniypq....tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvt

TIIMLNGLASKDQS-MAEYWPDESESEVTFGPFTITLIDEEHYDEISCRTMELrstTSKSRVQTVYQLQLTTWPITSeICASAISFMELHRRamVWNEAN
||.|.. |   |..  ..||||     | || . . |.  |   .   |....   .  . ..|| | ..| ||    .   . |.. | .   |  . .
tiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv...lkgddsrtvtqfhfteWPdkG.vpkhtssllklike..vkadhg

AKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
    |...||  | | || ..|. ||. . .  . ||||.  . .|. |   |    || ||. ... .|
qythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1812-1933 1.9e-20 67.6 In-house 19-146 (392) alignment 
Range on Protein: 1812-1933
Range on HMM: 19-146/392.0
STLLQEQFERLDMFTIKPRddelRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIS
|.|. |.|  |    | |.    ..|.. .|..||||.. || |..|  | . .  . ..|.|||..|..  .  .. .|.| . .. ||||.||. ...
salffeefhdlpgpdiypq....tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvt

TIIMLNGLASKD-----QSMAEY----WPDES
||.|.. |   |     ...| .    |||. 
tiamvtklkegdkgddartvaqfhftewPdkd
0040438 (Phosphotyrosine protein) phosphatases II 1813-2083 5.8e-63 208.4 In-house 18-280 (317) alignment 
Range on Protein: 1813-2083
Range on HMM: 18-280/317.0
TLLQEQFERLDMFtikP-RddELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE-NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIS
|.|.|.||.|. .   .    . ..|.   | .|||| | || | || .|  . . ....|||||. .|. .|. |. ||.||||||.||||.|......
talleefedllsl...kld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

TIIMLNGLASK-DQSMAEYWPDesESEVTFGPFTITLIDEEHYDEISCRTMELRSTtSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNEan
.|.||. |  . ..  |.|||.  ....|.|.||.||..||....|  ||.|.  .  .| . ||.... |.||    .  |  .. .. ...  ..|  
vivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWp.dhgvppspdllldfleavreale..

AKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYD
 .. |..|||..| | ||||. .  .||.|. |. |||..| |..|. |.||| ...||.|.. .|. ||  ..
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
subfamily_PTPN12_pd Subfamily PTPN12 1813-2075 3.5e-51 168.8 In-house 8-273 (290) alignment 
Range on Protein: 1813-2075
Range on HMM: 8-273/290.0
TLLQEQFERLDMFTIKPRDDE---LRTARNSMNVHKNRYHDKLPTDKSRPYLITEVEN-GTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYK
  ....|..| . . | ....     ..... ||.||||.| || ||||  | .. |. | .||||.|. | ..| ... .|.|||.|. ||||......
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

ISTIIMLNGLASKDQS-MAEYWPDESESEVTFGPFTITLIDEEHYD-EISCRTMELRSTtskSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWN
.. ..|.  .   ..   . |||.| |.|..||.|..||..|.. | ..  ||....     .  ..|||.. | ||   .. .|| | .|| . .   .
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWP.DhgvPssaksllelielvrelq

EanAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKL---VDVFQACKRVRAIRRGAVASLAQYEFIHSVL
|  ..|||..|||  | | ||| ...  | | |. ||.   .|||.   ..|  |  .| .  |||...  .
e..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykav
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1814-2077 1.1e-62 206.7 In-house 22-277 (288) alignment 
Range on Protein: 1814-2077
Range on HMM: 22-277/288.0
LLQEQFERLdmfTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTI
 ..|... |   .   ....  ..|.. | .||||.. || |  |  |   | |.|..|||||.. |. ||  .. ||.||..||.|||.||...|.|||
gfseeynsL...aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktsti

IMLNGLASKDQ-SMAEYWPDEsESEVTFGPFTITLIDEEHYDEISCRTMELRsttSKSRVQTVYQLQLTTWPITSeICASAISFMELHRRAMVWNEANak
.||..|  ...    |||||. . .. .| .|.||..... ...  |...|     |    .. |.| ..|| .. . .|.  ..|| |   | |.|.  
vmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhg.vPeskapllellrqvkvanqad..

DAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRL
  ||.||| .| |.|||| .|  ...... |. .||. . ...|  |   |  | |||||..||  
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Ptp69D_pd Subfamily Ptp69D 1814-2079 2.7e-53 176.1 In-house 23-286 (307) alignment 
Range on Protein: 1814-2079
Range on HMM: 23-286/307.0
LLQEQFERLDMFtikPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLI-TEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTI
.|.. .|.|        | . ... .  |  ||||.|  . || |  |  .. .. ..||||||. || .|  |.  | |. .|.|||||.. . .. .|
glakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

IMLNGLASKDQ-SMAEYWPDEseSEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKS----RVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNE
.||  |  |..  .| |||.|   || .|   ..|..||. ..   |....  .  .|      . | | . |.|.  |..  .| . ..| ...   ..
vmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelyk

ANakDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
 |   .||.|||. | | .|.| .|.|.|..|. |. ||.|.  | .|  |   | ||.||.|..  |  | 
ln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPRB_pd Subfamily PTPRB 1814-2079 3e-53 175.8 In-house 26-285 (293) alignment 
Range on Protein: 1814-2079
Range on HMM: 26-285/293.0
LLQEQFERLDMFTikpRDDELRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTI
 ..|..|.|  .    .| .  .|....|  ||||.. || |.||  |  .. |.|..||||...|||. .  |. || |||.|| ||||.|.. | |.|
rfseeyeelkavg...kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssii

IMLNGLASKDQS-MAEYWPDESEsEVTFGPFTITLIDEEHYDEISCRTMELRSttsKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNEANAK
.||  |  | .    ||||...| .|..|  ..||. ||....  .|.....    ... ..| |.. |.||   ..  .. ..... |.   . | .|.
vmltqlvekgkvkCeeYWPadee.pvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWp.dhgvPektktlldfvrtvreaiektas

DAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
..||.|||  | | |||| .|  .|.... | .||.|    ..|  |   | . .|| |||...  .|
krPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1814-2087 7.7e-47 154.4 In-house 16-301 (301) alignment 
Range on Protein: 1814-2087
Range on HMM: 16-301/301.0
LLQEQFERLDmftiKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE---NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIS
 ..||...|.    . .|..     ...| . ||...  . |. |  | .. .     ..|||||.. ||..|  |  .| |. .|. |||||....| .
kfeeqykelk....egedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

TIIMLNGLASKD-QSMAEYWPDESESEVTFGPFTITLIDEEHYDEISCRTMELR------------S--TTSKSRVQTVYQLQLTTWPITSEICASAISF
.|.|. .|  .  ..  .|||. .... .|||||.||..|  | .   | . ..            .  ..|.   ..| |||.| ||    .   .   
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

MELHRraMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYDIYEN
. ..   ..  .     .|..||| |. . .|..||.|  ||    |  |||||  |.||  . |||  | || .|. |.  ||   ..| |
qvidd..vihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1814-2079 2.8e-22 74.1 In-house 13-271 (288) alignment 
Range on Protein: 1814-2079
Range on HMM: 13-271/288.0
LLQEQFERLDM-FTIKPRDDELRTARNSM-NVHKNRYHDKLPTDKSRPYLItevENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIST
.||  .| |.  .   | .   ... . . |  ..||..    | .|  |    ..   ||.|  ..    |  .. .|.||  |.. .|.....  .  
vlqiaveglkkeyrdspneasidiidsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdvey

IIMLNGLASKD-QSMAEYWPDESESEVTFGPFtITLIDEEHyDEIS-C-RTMELRSTTSKSRVQTVYQLQLTTWPITsEICASAISFMELHRRAmvwnea
|.||. |  |  .  |||.| .   .. .| .  | . ... ..|    .   || .      . | .| |  |.    .  . .|.. |  .       
ivmlcellekGkeksaeyfPsklGekarigrl.ctvvkkkr.adidklvkvsllriskegeekvivkilhlleWddd.gvPenylsplrllevl......

NAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
.. . ||.||.. | | |||.     .|| | ..  . . . ... |. |. |. .  || ..| ..  .|
kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_egg_pd Subfamily egg 1814-2079 1.9e-19 64.5 In-house 12-270 (307) alignment 
Range on Protein: 1814-2079
Range on HMM: 12-270/307.0
LLQEQFERLDMFTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLitEVENGT---NYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIS
..||   || .      .  |.|| .. | .| | .     | ||  |  |...|    ..| |  . |    . |. .|.|| ||| ||||.||  .. 
ivqelerrlevleesvdeislttaasdnnlekarskrvhckdssrvkl..elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevq

TIIMLNGLASKdQSMAEYWPDE-SESEVT-FGPFTITLIDEEHYDEISCRTMELRSTTSKsrvqtVYQLQLTTWPITSEICASAISFMELHRRamvwneA
 |.||.      .    |||   |.| ||  | . |. .. ..  .   |  .|.   ..       .. |  |    .  .   | ... |.      .
yivmltsrkes.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.....deerflehwqgdvnnssdvysplrvlrk......l

NAKDAPIMVHCKDGEGATGTFCSLSSVLERL---NVEKlVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
     |..|....|   ..|. ..   |  |    . |   | .|.. .|  || .| |  .| |.. .. ...
rnlskpvvvqdilGvskaatlvaieiallsllrGpitk.slvlravvflrlrrrlsvesvllylfvyrlvlfff
0046845 (Phosphotyrosine protein) phosphatases II 1815-2085 2e-69 229.4 In-house 2-280 (284) alignment 
Range on Protein: 1815-2085
Range on HMM: 2-280/284.0
LQEQFERLDMFTIKPRdDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE--NGTNYINASFLPGY-----TKKDMFLGTQTPLPNTVGDFWRLVFDY
|.|.||.| ..|.|.   .|..|.   |..|||| | || |.|| .| .. .  ....|||||...||      .|  |. ||.||||||.||||.|...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KISTIIMLNGLASKDQ-SMAEYWPDEsESEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWN
....|.||..| ....  .| |||.| .. .|.|.||.||..||..| . .||.||. .  .. . ||.... |.||    ...|. ...|. | .  ..
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp.dhgvppspedlleflrlvrell

EANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEK---LVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYDIY
|.. .. ||.|||..| | ||||. |  .||.|. |.    |||..| ||.|  | |.| .|.||.|.. .|  || .. ..
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
DSPc_SM00195 1815-2078 4.1e-61 202.0 In-house 2-261 (263) alignment 
Range on Protein: 1815-2078
Range on HMM: 2-261/263.0
LQEQFERLDMFTIKPrddELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE-NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTII
|.|.||.|.. | .    | ..|. . |..|||| . || |..|  | .| . .|..||||... |..||  .  || |||.|| ||||.|.. |...|.
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNGLAS-KDQSMAEYWPDESESEVTFGPFTITLIDEEHYD-EISCRTMELRSTTSkSRVQTVYQLQLTTWPITsEICASAISFMELHRRAMVWNEANak
||.     . . ...|||.||... ||| ....|...|... ||  ||.||. ..  .  ..|.|.| ..||   ..  |. |..|| | .  ... .  
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts..

DAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLY
..||.|||..| | ||||......|..|. || ||.|. .|..|  | |.| .|.|| ||. ..  |
sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1815-2078 4.1e-61 202.0 In-house 2-261 (263) alignment 
Range on Protein: 1815-2078
Range on HMM: 2-261/263.0
LQEQFERLDMFTIKPrddELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVE-NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTII
|.|.||.|.. | .    | ..|. . |..|||| . || |..|  | .| . .|..||||... |..||  .  || |||.|| ||||.|.. |...|.
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNGLAS-KDQSMAEYWPDESESEVTFGPFTITLIDEEHYD-EISCRTMELRSTTSkSRVQTVYQLQLTTWPITsEICASAISFMELHRRAMVWNEANak
||.     . . ...|||.||... ||| ....|...|... ||  ||.||. ..  .  ..|.|.| ..||   ..  |. |..|| | .  ... .  
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts..

DAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLY
..||.|||..| | ||||......|..|. || ||.|. .|..|  | |.| .|.|| ||. ..  |
sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPRN_pd Subfamily PTPRN 1815-2073 6.2e-35 115.3 In-house 31-286 (297) alignment 
Range on Protein: 1815-2073
Range on HMM: 31-286/297.0
LQEQFERLDMFTIKPRDDElrTARNSMNVHKNRYHDKLPTDKSRPYLITE-VENGTNYINASFLPGY-TKKDMFLGTQTPLPNTVGDFWRLVFDYKISTI
|....| |  .  .|.  |  .|..  ||.|||... || |.||  | .|  .. ..|||||..     .. ... ||.||..|| |||..|..  .  |
lekewealcayeaepstke..vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

IMLNGLASKDQS-MAEYWPDESESevTFGPFTITLIDEEHY-DEISCRTMELRSTTsKSRVQTVYQLQLTTWPITsEICASAISFMELHRRamVWNEANA
..|  |. .. . ...||||| ..  ... . . |. |  . |.   |.. |.    .|. .|| |.   .|| . .. ||| |..|. |.  |      
vnltrleeegvkqckrywpdeGse..vyhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpee.gvPasaksllefrrk..vnksyrG

KDAPIMVHCKDGEGATGTFCSLSSVLERLNV-EKLVDVFQACKRVRAIRRGAVASLAQYEFIHS
. .||.||| || | ||... .  ||.||.   | .|.  . . .|  | | |.. .|.||. .
rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1815-2074 1.7e-34 114.0 In-house 22-274 (439) alignment 
Range on Protein: 1815-2074
Range on HMM: 22-274/439.0
LQEQFERLDmfTIKPR-DDELRTARNSMNVHKNRYHDKLPTDKSRPYL--ITEVEnGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKIST
..| || ..  ...|    .   | .. .  ||||.|  . | .|  |  |  |   . |||| .. || ...... ||.|  .|. ||||||.. | .|
fkeifekin..stspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvp.hshyinanyikGyyddklyiatqgpkkettddfwrlviekktvt

IIMLNGLASKDQsmaeYWPdeSESEVTFGPFTITL---IDEEHYDEISCRTMELRSTTSKSRvqTVYQLQLTTWPiTSEICASAISFMELHrRAMVWNEA
|.||  |    .    |||  |..|| .|  ..     |.  .|     . .. | || | |  || |.. ..||   .. | |   ...  ||.   . 
ivmltnlvesyk....ywp..sdaevcygdiavrvdrnielpnyvirgfkvfnerdtteker..tvlqfhyiawp.dknvpaqashvldfl.rainsand

NAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSV
. .  |..|||  | | |||  .|   ||.|..|. ||.    | .|  |.  | .|.|| ||.  
keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiyna
subfamily_PTPRA_pd Subfamily PTPRA 1816-2078 4e-55 182.0 In-house 35-294 (330) alignment 
Range on Protein: 1816-2078
Range on HMM: 35-294/330.0
QEQFERLDMFTIKprdDELRTARNSMNVHKNRYHDKLPTDKSRPYLI-TEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIM
.|.|. |   .|.     | .| .  | .|||. . || | || .|   | .. ..||||||. || .|| |. .| |. .|| ||||.....| .||.|
reefnalPagpiq...atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativm

LNGLASKDQ-SMAEYWPDEseSEVTFGPFTITLIDEEHYDEISCRTMELR---STTSKSRVQTVYQLQLTTWPITsEICASAISFMELHRRAMVWNEANA
|  |  ...   | |||||    ||.|  .... ||.   ... | . ..    .| . ... | |. .|.||    . . .|  ..| ..    |. .|
ltelkerkeekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv.GvPfepiGmlkllkkvkklnqqsa

KdaPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLY
   ||.|||  | | ||||. |..||||.. |..||||.. ||.|. |   | .. |||||. ||. |
g..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1816-2074 7.1e-45 148.1 In-house 9-261 (283) alignment 
Range on Protein: 1816-2074
Range on HMM: 9-261/283.0
QEQFERLDMFTIKPRDDELRTARNsmNVHKNRYHDKLPTDKSRPYLITEVEngtNYINASFLP---GYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTI
. ..|.|. ... ..| .. .|..  | .|||... .|.|. |  | .| .   .||||.|.|    | ..  .. .|.|| .|| |||..||| ||..|
klfrevlkrlsvpdldadiasade..nkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

IMLNGLASK-DQSMAEYWPDESesEVTFGPFTITLIDEEHYDEISCRTMELRSTTS-KSRVQtVYQLQLTTWpiTSEICASAISFMeLHRRAMVWNEANA
.||  |    ..  . ||| .    . .|.||.|| .|   .  . . . ||  .| || .  .   |.  |  ..    . |  . ..   .. .  . 
vmltklqedlrikCsqyWPkrG..sedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidW..leygeqaiinsl.vkfnkvislqtes

KDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSV
|..||.|||  | | |..|...|. .. .  | .||||.  | .|  | .|| .| || ..| .
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhel
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1816-2078 9.9e-35 114.8 In-house 9-258 (267) alignment 
Range on Protein: 1816-2078
Range on HMM: 9-258/267.0
QEQFERLDmfTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENgtnYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML
...|| ..   | .    . .   . |  .||. |.|| |..|  | |. |.   |||||.. || .| .|. || || ||..||. .. |.|...|..|
ekefelik..kisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NglASKDQSMAEYWPDESESEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQltTWPITSEicasAISFMELHRRAMVWNEANAKDAPI
    .  . .  .|| .      .  .|.    |.  ..    |.||.     ..  |.|  .   | | ..       ...     .  |. .  . |.
t..kvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyyk..kwnintn....nkpylkplfgilaknqlengnrPl

MVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLY
.|.|.|| | .|||  . | |||.  |  .|.|.  ...|  | | | .. .| .|| .|  |
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_PTPN3_pd Subfamily PTPN3 1818-2080 2.2e-39 130.1 In-house 20-277 (280) alignment 
Range on Protein: 1818-2080
Range on HMM: 20-277/280.0
QFERLdmfTIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLiteVENGTNYINASFL----PGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTII
|||.|     | .. .. .|| . |..||||.| || |. |  |   .|. |.||||...    |. .    .. || ||..|. |||..|.. |.|.|.
qfeql...yrkkpglaisaarkpenlsknryrdilpydatrvkl...kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLNGLASKD-QSMAEYWPDeSESEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKsRVQTVYQLQLTTWPiTSEICASAISFMELHRRamVWNEANAKD
||  |  .  .   .|||. .| |...| |....  |..  ..  | . |. ...| . ... ||| . ||  ...  .. .|.|. .|  | .  ..|.
mlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketk.eerkilqlqylaWp.dhgvPddsadflefver..vrklrsgke

APIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFI-HSVLRLYLD
 |..|||  | | || .  |   |  .. .. | . .  ...|  |   | . .||.|. ...|..| .
ePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1819-2079 8.9e-43 141.1 In-house 16-277 (287) alignment 
Range on Protein: 1819-2079
Range on HMM: 16-277/287.0
FERLDMFTiKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML-NG
...|   . .     ...| . ..|.|||| | || |..|  | .| | |..|||| ....||... |. .|.|.. ||.||||.|.. . ...|..   
vdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtre

LASKDQSMAEYWPDEsESEVTFGPFTITLIDEEHYD-EISCRTMELRSTTSKSrVQTVYQLQLTTWPITSeICASAISFMELHRRA---MVWNEANAKDA
.    .   .|||.  |  .  | ....|.| .  . | . |.. |    ..   . | ||.| .||  . .  .|.... .       .  .   ..  
veearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletre.arvvkqldllswPdkv.laPtavglirfvldvkqhielardasevG

PIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
|..||.. | | .|.. ..  ...||.    ||| ..  |.|  |.. | .  |. ..   |  | 
PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1824-2078 1e-56 187.5 In-house 28-287 (325) alignment 
Range on Protein: 1824-2078
Range on HMM: 28-287/325.0
MFTIKPRDDEL--RTARNSMNVHKNRYHDKLPTDKSRPYLITEVENG-TNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLAS
 | . | ||    ..|    |. |||... .. ||||. | |  ... ..|||||.|  . |||.|| .|.||..|..|.||||.|.. | ...|| |  
efgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldl

KDQSMAEYWPDESESEVTFGPFTITLIDEEHYDEISCRTMELRStTSKSRVQTVYQLQLTTWP--ITSEICASAISFMELHRRAMVWNEANAK-DAPIMV
.... | |||.|    .|||.. . |.  |.. .   | ....  ..|   ..| |.|| .|.   . .  |. ||...|         ||.|  .||.|
gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkq.vkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilv

HCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLY
|| .| | ||.| || |.|...  |  ||.|.  |..|. |   | .  || .|.  |  .
hcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_PTPN13_pd Subfamily PTPN13 1824-2075 1.4e-38 127.7 In-house 20-265 (273) alignment 
Range on Protein: 1824-2075
Range on HMM: 20-265/273.0
MFTIKPRDdELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVEngtnYINASFLPGYTKKDMF--LGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASK
.  .|| | . .....  | .||||.. || |..|  |  |      |||||..     || .  . .| |||.|| |||..|.. | . |.|.     |
lrelkpld.tcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekek

DQ-SMAEYWPDESESEVTFGP-FTITLIDEEHYDEISCRTMELRSTTSkSRVQTVYQLQLTTWPItSEICASAISFMELHRRAMVWNEanaKDAPIMVHC
..     |||.. .....    ....|.. ...|. . |..... . | .... | .|....||   .. .|| ..... ..    ..   . .||.|||
gkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPd.hgvPssaaellqfvaevrrlqt...dagPivvhc

KDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVL
  | | .||. ..  ||. .. .| .|| .  ...|  |.| | .  || |.. ..
saGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_PTPN14_pd Subfamily PTPN14 1826-2080 9.3e-39 128.2 In-house 33-297 (300) alignment 
Range on Protein: 1826-2080
Range on HMM: 33-297/300.0
TIKPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENGTNYINASFLP--GYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGL--ASK
. |  | .| ||..  |..|||..| || ...|  |..  || |.||||| .     .|.  .. .|.||..|| |||..|.. ... |.||       |
pkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

DQSMaEYWPDE--SESEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKsRVQTVYQLQLTTWPIT--SEICASAISFME----LHRRAMVWNEANAKDA
..|. .|.|..  ....|.|| | .|    |. | .  ....|.   || . .||. || | ||     |   . .|..|    . |..   .|.. .. 
eksf.kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk.eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskP

PIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLD
|..||| .| | ||       ... |. .. .|. .. .|.|  |   |..||||.|...||  ||.
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1828-2080 1.4e-52 173.5 In-house 30-278 (315) alignment 
Range on Protein: 1828-2080
Range on HMM: 30-278/315.0
KPRDDELRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQ-SM
 |   . |.||...| .||||.. || |..|  | . . .   .|||||..... .   .. .|.||. .| ||||.|...|..||.|.. .   |. . 
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc

AEYWPDESESEVTFGPFTITLIDEEHYDEISCRTMELRSTTSksrVQTVYQLQLTTWPITSEICASAiSFMELHRRamVWNEANAKDAPIMVHCKDGEGA
. ||||.    | || . ..|.. |   .   | . .| . .    .|| | |.| ||       .. |...| .   |  . . |. ...|||  | | 
rqywPdrkadsvefGsikvellsleadtdgvarklvtrksee...srtvtqfqftewPdkGvdkqts.sllklike..vkadngkkefsllvhcsaGvGr

TGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLD
|| ..|. .|..... .. ||||.  | .|| |   | .  .| ||. ... .| 
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1829-2089 7.7e-67 220.6 In-house 33-296 (305) alignment 
Range on Protein: 1829-2089
Range on HMM: 33-296/305.0
PRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENG-TNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQSM-A
 ... .   ....|..|||.... . |..|  | .. ... ..|||||.. || .|. .. .|.||.||| |||||....|.|||.|| .|   ...   
eeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCr

EYWPDESESEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMvWNEANAKDAPIMVHCKDGEGAT
 |||..   .. ||.|...| .|... .   | ...    ...  .|| |.|||.||    .  .| |...| .| .  .  . |. |..||| .| | |
qYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWP.dhGvpqfatsllslikrvq.kdqkkdkgvpllVhCsagvgRt

GTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYD---IYENYR
|.|....  ||||. |. ||||.  |..|  | ..| .|.|| |.| .| ... . |   | .|.|
GvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1829-2073 3.2e-20 67.2 In-house 20-289 (297) alignment 
Range on Protein: 1829-2073
Range on HMM: 20-289/297.0
PRDDELRTARNSMNVHKNRYHDKLPTDKSRPYLItEVENGTNYINASFL--PGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQS-M
 | ... .|. .  ..||||.| | ||..|  |   |  ...|||| ..  |   ..  .. .| || .|| |||.||..  . .|.|.  |    ..  
argesfssakrnsslrknryrdilatddtrvkll.rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

AEYWPDESESEVTFGPFTITLIDE--EHYDEISCRTMELRSTtskSRVQTVYQLQLTTWPI---T----------SEICASAISF--M-ELHR--RAMVW
| |||.  .   . | . .  . .  ...| .    ..|      |. . |   |  .||               ...|. .|.   |  |     |||.
apywpsvvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvf

------NEANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHS
      . .  ..|...|||  | | .|       .|..|  ... ||    . .|  |   | .| |.|....
lqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyd
subfamily_CG7180_pd Subfamily CG7180 1830-2076 2e-53 176.0 In-house 30-287 (296) alignment 
Range on Protein: 1830-2076
Range on HMM: 30-287/296.0
RDDELRTARNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQSMAEY
. .. ... .. |  |||. . .| |. |..| . . |. ..||||..  ...||  .. |..|  .||..|||||.| .||....|    .  . . .|
eigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsy

WPDESesEVTFGPFTITLIDEEHYDEISCRTMELRST---------TSKSRVQTVYQLQLTTWPITSEICASAISFMELHRRAMVWNEAN---AKDAPIM
|| .|  .  .|.. . .. |..| ..  ||. |  .           |  . .| ..|||.|..  ..  |. ...|| ||. .| | .    . .|..
wpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLR
|...|| . .| ....   || .. |. ||||.| |..|  |.. | .  .| .|  || 
vvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1830-2076 4.5e-17 56.6 In-house 40-287 (310) alignment 
Range on Protein: 1830-2076
Range on HMM: 40-287/310.0
RDDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQSM-AEY
.|  |       ..||||| | .  |.||  |  .     .|| | ..     .. |. .| ||  |. ||||..|. .  .|..|   . . .     |
qdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPDESESEvTFGPFTITLIDEEHyDEISCRTMELRSTTSKSRV--Q----TVYQLQLTTWPITSEICASAISFMELHRRAMvwneANAKDAPIMVHCKDG
||    .| |.|   .| . |   .|.    . .     .  |  |       ...|  ||   .          . .| .    |. .  | .|||  |
wpslgvte.tygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrll....aqvrhgpcvvhcsag

EGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLR
 . ... ..|   ...|.  . ||. .    ..  |   . .  || .|. |  
kdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1831-2081 5e-45 148.8 In-house 30-278 (281) alignment 
Range on Protein: 1831-2081
Range on HMM: 30-278/281.0
DDELRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKD-QSMAEY
|.  . ...  ||.||||..    |..|  .  .| .. |.||||.|.|||...  .. ||.|.|... .||..|...|.|.|.|.     ..      |
dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrY

WPdESESEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRvqTVYQLQLTTWPITsEICASAISFMELHRRAMVWnEANAKDAPIMVHCKDGEGATGT
|| . .||...| .|.. . ||.  .  .|...|. .....|  .| ||. |.|| .  . |..  ..| ..  .   . . ..||...||  | | |||
WP.ddnselkygdvtvkstaeeekatyierkfkleresgetr..eveqlaytaWPdh.GvPattkellefrkevlkl.tekktkaplvihCsaGvGrtGt

FCSLSSVLERLNVE-KLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDS
. .|  ...... | . .|| .  . .|  |   | ...||||.. ..  .|| 
yialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1831-2080 4.6e-24 80.0 In-house 30-279 (307) alignment 
Range on Protein: 1831-2080
Range on HMM: 30-279/307.0
DDELRTARNSMNVHKNRYHDKLPTDKSRPYLITEvENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKD-QSMAEYW
 . . .   | | .||||.|    ||.|  . ..    ..|| | .|   .|   |. .| || ||. .|| .. . |. ..|||  .         .||
pegvtveafsantdknryqdvkcqdkgrivvkfd.glasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqyw

PDESESEVTFG--PFTITLIDE----EHYDEISCRTMELRSTTsKSRVQTVYQLQLTTWPITS--EICASAISFMElhrramvwnEANAKDAPIMVHCKD
| |   . .||  | ||.. .        ||      .|.     .. .|. .|| . ||     .|  .|| ..|           . .  |..|||  
pleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltainlle.........avrydtnpvvvhcsa

GEGATGTFCSLSSVLERL-NVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLY-LD
| | .||  ..| | ... . .   |. .  . .|. |. |. . ||| ..| ||  | |.
GvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_PTPRD_pd Subfamily PTPRD 1832-2083 1.8e-68 226.6 In-house 38-285 (564) alignment 
Range on Protein: 1832-2083
Range on HMM: 38-285/564.0
DELRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQ-SMAEYW
 . ..|....| .||||.. .. |.||  |  .| ..|..||||||. ||.|.  .. || ||..|. ||||.|.....|||.||. |  |..  ...||
ftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYW

PDEsEsEVTFGPFTITLIDEEHYDEISCRTMELrSTTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNEanAKDAPIMVHCKDGEGATGTF
|.. . . |.| .|.|| .||.. ....||..| .....| ...| | . | ||  . .  || |...| |.   .||   .  ||.|||  | | ||||
Pek.g.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWP.dhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtf

CSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYD
. ....|||.. ||.||..|  |..|. |   | .  || |||...  .|....
ividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
subfamily_PTPN9_pd Subfamily PTPN9 1832-2075 3.8e-46 152.5 In-house 32-286 (297) alignment 
Range on Protein: 1832-2075
Range on HMM: 32-286/297.0
DELRTARNSMNVHKNRYHDKLPTDKSRPYLITE-VENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQ-SMAEYW
 .. ...  .|..||||.| |  |..|  | ..  .. ..||||.|. || .|. |..|| ||..|| ||||.|.. .. .|.|   .  . .   ..||
GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyW

PDESESEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKsRVQTVYQLQLTTWPI--TSEICASAISFMELHRRAMV--------WNEANAKDAPIMVHC
|.|.||   || .... .. |....   |..|.. .. . . ..|   |...||   . . .|| . ..|  |..           .. .... ||.|||
pleeessaefgdlsvsnveveeeedykvrvleiknvkte.esrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhc

KDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVL
  | | ||||..|   |.||. .  |||... |..|. |  ..    |||| .  .
saGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1832-2069 2.2e-24 80.7 In-house 40-271 (301) alignment 
Range on Protein: 1832-2069
Range on HMM: 40-271/301.0
DELRTARNSMNVHKNRYhDKLPTDKSRPylITEVENGTN-YINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKD-QSMAEYW
|..  .   .. .|.|| ...| . |    .  ...|.   | | ..|   . . |. ||.||.||  ||| ..  |.. .|.||     |  . ..|| 
dhitesyaylpkdkhry.ptvPckPsta..vevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeyl

PDESESEVTFGPFTITLIDEEH--YDEISCRTMELRSTTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRraMVwneaNAKDAPIMVHCKDGEGATG
| . ....  | |.|.. ..|.   ..|| ||.|.. .| |   .||   | ..|.   ..  | .  ..|    .|       . ||.||| .| | . 
pvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewt.drgvPkshaelfdlme..lv....kksekPivvhcsaGiGrsv

TFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYE
.| .   .  ... .. ... .| |..|  |  .|    |  
afigteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1832-2083 2.5e-19 64.2 In-house 38-291 (305) alignment 
Range on Protein: 1832-2083
Range on HMM: 38-291/305.0
DELRTARNSMNVHKNRYHDKLPTDKSRPYLitEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKD-QSMAEYWP
. ... ... . .||||.|    |. |  |  |     .|| | ..   |.   |. ||.|| .|  ||| . .. |. .|.||  |  |  .  .||..
ekmkafkeaqeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfa

DESESEVTFGPF--TITLIDEeHYD--------EISCRTMELRSTTSKSRVQTVYQLQLTTWPITsEICASAISFMELHRRAmvwneaNAKDAPIMVHCK
 . . ...|      |..  |            .   .  .|    . .... | .     ||    . |. .. .||  .|       .   ||.||| 
skdkdvlefeekgqkisvkfe.ssvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdr.gvpaadlailelleka......rpskgpivvhcs

DGEGATGTFCSLSSVLERLNVEKLV-DVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYD
 | | ||.   |  .|..|   . . |  .  ...|  |  .. . ||| |.| |.  |.   .
agigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1832-2077 3.5e-17 57.0 In-house 27-267 (281) alignment 
Range on Protein: 1832-2077
Range on HMM: 27-267/281.0
DELRTARNSMNVHKNRYHDKLPTDKSRPYLIT--EVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLAS-KDQSMAEY
|   .  . .| .|||| .    | ||  |      .| |.|| | ..     |  .. || |  .|  ||||.... . ..|.||  .   . .  |||
dlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPDESESEVTFGPFTITLIDEEHYDEISCRTMELrSTTSKSRVQTVYQlqLTTWPITsEICASAISFMELHRRamvwneANAKDAPIMVHCKDGEGATGT
.| ..   . |  ....  |      .    ..| |   ..|. | .      ||   ..  |.  .... |.        |. .| ..||  | | .||
fprnahcclqfdklsvsyedstvnkslvttrlnl.syegetrlithwl..wkewpdw.qvpessevmlkilrk......irarstppvihcsagvgrsgt

FCSLSSVLERLNVE-KLVDVFQACKRVRAIRRG-AVASLAQYEFIHSVLRL
. ..   |. .     | |. |   ..|   |  .| .| || .|  ||  
lmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1833-2083 8.7e-117 384.5 In-house 40-296 (315) alignment 
Range on Protein: 1833-2083
Range on HMM: 40-296/315.0
ELRTARNSMNVHKNRYHDKLPTDKSRPYL-ITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQSMAE-YWP
 |..|....|..||||......||||..| ..|......|.||.|..||.||......|.|....|.|||||||...|..|.||..|.......|| |||
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

DEsesEVTFGPFTITLIDEEHYDEISCRTMelrSTTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNEANAkdAPIMVHCKDGEGATGTFC
|.   .|..|..|.|...||...|...||.   |.........|.||..|.|| ........|..|.|.|..........  ..|.|||..|.|.||||.
dk...kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfi

SLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVL-------------RLYLDSYD
.|..||.....|...||......||..|...|....||.||...|             .|||..||
tldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryd
0045098 (Phosphotyrosine protein) phosphatases II 1833-2079 7.7e-54 178.3 In-house 24-272 (278) alignment 
Range on Protein: 1833-2079
Range on HMM: 24-272/278.0
ELRTARNSMNVHKNRYHDKLPTDKSRPYlitevengtNYINASFLPGYtkKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASK-DQSMAEYWPD
|  .|    |..||||.| || | || .         .|||||...||  .. |. || |||.|| ||||......|..|.||..|  .  . .|.|||.
eitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

esESEVTFGPFTITLIDEEHYDEISCRTMELRSTT---SKSRVQTVYQLQLTTWPITSEICASA-ISFMELHRRAMVWNE-----------ANAKDAPIM
  .. .|.|.||.||..||..|..  ||.... .|   .     .|..|....||  .    .   || || ..   ...           .. .. |. 
..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCKDGEGATGTFCSLSSVLERLnvEKLVDVFQACKRVRAIRRG-AVASLAQYEFIHSVLRLYL
|||. | | |||.. .  .||.|  |. ||...| | .|  |.| || .| ||.|.. .|...|
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN1_pd Subfamily PTPN1 1833-2071 1.2e-35 117.6 In-house 23-263 (290) alignment 
Range on Protein: 1833-2071
Range on HMM: 23-263/290.0
ELRTARNSMNVHKNRYHDKLPTDKSRPYLITEvENgtNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQS-MAEYWPD
. |.|..  |  .||| |  | |.||  |  . .|  .|||||..     |  .. || ||||||. ||..|.. |  ...||| .  |.|   |.||| 
ptreaklpenrnlnryrdvspydhsriklera.dn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

-ESESEVTFG--PFTITLIDEEHYDEISCRTMELRSTTSKsRVQTVYQLQLTTWPITSeICASAISFMELHRRAMVWNEANAKDAPIMVHCKDGEGATGT
 |.|.|...    ....|| ||....   |..||   ... . .....   ||||  . .  |  .|...  .       . .  | ..||  | | .||
geeekellledtklkvkliseerksyytvrllelenlktq.etreilhfhyttwpdfg.vpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCSLSSVLERLNVEKL---VDVFQACKRVRAIRRGAVASLAQYEFI
|| . ..| ... ..    ||. .    .|  | | .    | .| 
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfs
0049772 (Phosphotyrosine protein) phosphatases II 1834-2081 7.5e-29 96.9 In-house 38-282 (314) alignment 
Range on Protein: 1834-2081
Range on HMM: 38-282/314.0
LRTARNSMNVHKNRYHDKLPTDkSRPYLITEVENGTNYINASFLPGYtKKdmFLGTQTPLPNTVGDF----------WRLVF--DYKISTIIM-------
. .|.  .| .||||.| || | .|  | ..  .|..|||||.. |. .|  |. ||.||..|| ||          ||.|.  |... .| |       
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lk..fIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LNGLASK-DQSMAEYWPDESesevtfgpftitlidEEHYDEISCrtmelrsttsKSRVQTVYQLQL--TTWPiTSEICASAISFME
              |..|  . ..  |.....                 ||.||   .          . .. ..... .   ..| ..|.  ... |.|
delsrLdaAlgKtpllildgngneptaadlellk...............eelydpelf..........erlgikylripvpDgsap.lledfdeflefie

LHrramvwneanAKDAPIMVHCKDGEGATGTFCSLSSVLERLNveklVDVFQACKRVRAIRR-----GAVASLAQYEFIHSVLRLYLDS
 .           |. |. ||||.| | ||||. .  .. .|.    |.. .| ..||..|      |.. .| |||||. .|. ||. 
ea..........dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf
0040439 (Phosphotyrosine protein) phosphatases II 1835-2079 6.9e-57 188.2 In-house 4-246 (249) alignment 
Range on Protein: 1835-2079
Range on HMM: 4-246/249.0
RTARNSMNVHKNRYHDKLPTDKSRPYLITEVE-NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASK-DQSMAEYWPDe
..|.   |..||||.| || | ||..|    . ....|||||...||  |. |. ||.|||.||.||||......|..|.||. |  .  .  |.|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

sESEVTFGPFTITLIDEEHYDEISCRTMELRSTtSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNEANAKDAPIMVHCKDGEGATGTFCSL
 ......| ||.||...|..|.. .||.||  .  .. . ||...| | ||    .. |  ..... .... ..|.. |. |..|||..| | ||||. .
.ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

SSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
  .||.|. |. ||...| | .|  |.||| .. ||.|.. .|. .|
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1835-2083 4.7e-51 168.7 In-house 44-288 (297) alignment 
Range on Protein: 1835-2083
Range on HMM: 44-288/297.0
RTARNSMNVHKNRYHDKLPTDKSRPYLITEVEN-GTNYINASFLPGYTKkdMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQSMAEYWPDES
 .|.. .| .|.||.. ||.|.||  |    ..   .|.||||..|. .   .. ||.| ..|| |||..|.|...|||.||| .  .|.. | ||.|..
tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkg

EseVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRvQTVYQLQLTTWPITSEIC-ASAISFMELHRRAMVWNEANAKDaPIMVHCKDGEGATGTFCSL
   .|||  ...|   ..    . |..|..   .|.| . | | | . ||  ..    || |...|        . ||.  |..|||  | | || ....
v..ttfGdvsvvllsvsereGfikrelevtkgkakar.rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvllti

SSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYD
 ||. . . || ||.|.  |..|  |   |    ||.|.. ..  .| | |
dsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_PTPRK_pd Subfamily PTPRK 1836-2074 4.4e-58 191.6 In-house 37-272 (314) alignment 
Range on Protein: 1836-2074
Range on HMM: 37-272/314.0
TARNSMNVHKNRYHDKLPTDKSRPYLITEVEN-GTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKD-QSMAEYWPDES
.|..  | .|||..| |. |.||. |||  ..  ..||||... .|..   |. || ||..|| ||||||.|.. ..|.||. | ..      .|||...
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

ESevtFGPFTITLIDEEHYDEISCRTMELRS-TTSKSRVQTVYQLQLTTWPITsEICASAISFMELHRRAMVWNEAnaKDAPIMVHCKDGEGATGTFCSL
|    .|.. ..|.. |   |.  |.. ..  . ... ...| |.| ..||   ..  || ....| ||   ..|   .. .|.|||  | | ||||. .
ev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiai

SSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSV
..||. .. |..||||.| | .|. .   |    || ||. |
divldmieregvvdvfnavktlrsrkvnmveteeqykfiydv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1836-2087 6e-58 191.4 In-house 40-288 (318) alignment 
Range on Protein: 1836-2087
Range on HMM: 40-288/318.0
TARNSMNVHKNRYHDKLPTDKSRPYLI-TEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKD-QSMAEYWPDES
 . ...| .|||| . |. |..|  |  .|.|.|..||||....||..|  .. .|.|||.|. ||||.|.. . ..|.||  .  .  . .. |||.. 
kslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg

esEVTFGPFTITLIDEEHYDEISCRTMELRStTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNEANaKDAPIMVHCKDGEGATGTFCSLS
    ..|  ...| .| ....   |.....  | .. ...| | . |.||  . . .|. |...| |..  ... . .  ||.|||  | | ||.|. ..
..srsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWp.degvpesgaslldlvrqvskaqqks.gagpivvhCsaGvGrtGvfiavd

SVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYDIYEN
..|||.. |.||||||  |..|  |   |    |||||. ||  .| |.| . .
illerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
0042113 (Phosphotyrosine protein) phosphatases II 1836-2079 2.9e-54 179.4 In-house 3-243 (245) alignment 
Range on Protein: 1836-2079
Range on HMM: 3-243/245.0
TARNSMNVHKNRYHDKLPTDKSRPYLITEVEN-GTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKD-QSMAEYWPDes
.|.   |..|||| | || | .| .|  . .. ...|||||. .||  .. |. || |||.||.||||......|.||.||. .  .. .  |.|||.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

ESEVTFGPFTITLIDEEHYDEISCRTMELRStTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNEAnAKDAPIMVHCKDGEGATGTFCSLS
....|.| ||.||..|||.|.. .||.|.   . .. ...|.... . ||    .. .  .. ......  . ..  .. |..|||..| | ||||. . 
gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwp.dhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaay

SVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
 .||.|. |. |....| |..|  |.||| .. ||.|.. .|. .|
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_eak_pd Subfamily eak 1836-1987 2e-10 34.6 In-house 46-199 (332) alignment 
Range on Protein: 1836-1987
Range on HMM: 46-199/332.0
TARNSMNVHKNrYHDKLPTDKSRPYLITEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIML-NGLASKDQSMAEYWPDESE
 ..   .|..|   . .| |.    | .   |   ||||| .        .. |  .  . |  ||..|.. |  .|..| . .  | .    |.||.. 
etarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

SEVTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRVQ--TVYQLQLTTWPITSE
 |. || . ..  .  . . .  | .||.      ||.  .|.    || |.  .
eelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyed
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1837-2085 1.7e-61 202.6 In-house 4-248 (250) alignment 
Range on Protein: 1837-2085
Range on HMM: 4-248/250.0
ARNSMNVHKNRYHDKLPTDKSRPYLITEV-ENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQSMAEYWPDE-SE
|..  | .|||| | .. |.||  | .|  .. ..||||||| ||.....|. ||.||..|. ||||.|...|..||.||. |  ... . .||| | .|
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

sevTFGPFTITLIDEEHYDEISCRTMELRSTTsKSRVQTVYQLQLTTWPITSeICASAISFMELHRRAMVwNEANAKDAPIMVHCKDGEGATGTFCSLSS
   ..|  |..| ..|.. ..  |.. | ... |.  ..| ||. ..||  . . . | . .|| ..    .. .|..||..|.|  | | .|.|. ...
...kyGdvtvsllskeefadytkrklklskak.kaderivrqlhfvvWPdkg.vPevatavLellkkvqa.sqqqagnaPvivqCsaGvgrsGafiaida

VLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYDIY
|||||. || ||||.  |..|. | .|| ||.|| |.....  .|||.. |
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedy
0037934 (Phosphotyrosine protein) phosphatases II 1837-2078 7.5e-50 165.1 In-house 5-241 (243) alignment 
Range on Protein: 1837-2078
Range on HMM: 5-241/243.0
ARNSMNVHKNRYHDKLPTDKSRPYLiteveNGTNYINASFLPGYtkkDMFLGTQTPLPNTVGD----FWRLVFDYKISTIIMLNGLA-SKDQSMAEYWPd
|.  .|..|||| | || | || .|     .|..||||.. ...   . .  || |||.|| |    |||......|..|.||. |   . . .|.||| 
allpenlsknrysdilpydhsrvkl.....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

eseS-EvTFGPFTITLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNE------ANAKDAPIMVHCKDGEG
   . . |.|.||.||..|||.|..  ||..|. .  .  ...|.... . ||    .  |  ....... .  . |      |. .. |. |||. | |
...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

ATGTFCSLSSVLERLnveKlVDVFQACKRVRAIRRG-AVASLAQYEFIHSVLRLY
 |||.. .  .|..|   . ||...| |..|. | | || .. ||.|.. .|. .
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1837-2073 5e-28 92.9 In-house 3-235 (239) alignment 
Range on Protein: 1837-2073
Range on HMM: 3-235/239.0
ARNSMNVHKNRYHDKLPTDKSRPYLITEV-ENGTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLAS-KDQSMAEYWPDes
|.. .|  |||| . .  |.||  |     .  ..|||||.|  |      .. ||  .  . |||||.... .   |.|| ||   . .   .||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..

eSEVTFGPFTITLIDEEHYDEISCRTMELrSTTSKSRVQTVYQLQLTTWPITsEICASAISFMELHRRamVWNEANAKDAPIMVHCKDGEGATGTFCSLS
 |   .  . .||   | . .   ||. . |   ..  . ||| ..| ||    .   | . . |.|.  . ...     | ..||  | | ||.|  . 
.stskycnlrvtlrktevfadyiirtfvm.sqvgqteeryvyqyhftvwpdk.gvpqyatavlglrrk..itkdslpgarpwvihcsagvgrtgaflvid

SVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHS
..| . . .| ||.|.  | .|  |   | .  || ||| 
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1837-2073 5.9e-28 92.6 In-house 2-234 (239) alignment 
Range on Protein: 1837-2073
Range on HMM: 2-234/239.0
ARNSMNVHKNRYHDKLPTDKSRPYLITEV-ENGTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLAS-KDQSMAEYWPDes
|.. .|  |||| . .  |.||  |     .  ..|||||.|  |      .. ||  .  . |||||.... .   |.|| ||   . .   .||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..

eSEVTFGPFTITLIDEEHYDEISCRTMELrSTTSKSRVQTVYQLQLTTWPITsEICASAISFMELHRRamVWNEANAKDAPIMVHCKDGEGATGTFCSLS
 |   .  . .||   | . .   ||. . |   ..  . ||| ..| ||    .   | . . |.|.  . ...     | ..||  | | ||.|  . 
.stskycnlrvtlrktevfadyiirtfvm.sqvgqteeryvyqyhftvwpdk.gvpqyatavlglrrk..itkdslpgarpwvihcsagvgrtgaflvid

SVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHS
..| . . .| ||.|.  | .|  |   | .  || ||| 
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_ptpA1_pd Subfamily ptpA1 1838-2040 6.8e-22 72.8 In-house 43-257 (418) alignment 
Range on Protein: 1838-2040
Range on HMM: 43-257/418.0
RNSMNVHKNRYHDKLPTDKSRPYLIT-EVENGTNYINASFLPGYTKKDmFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQ-SMAEYWPDESES
 .  |  |||| . || ...|  |   . ..|..|||| .. |   |. |. || |||||. ||||.|.. .   |.||.  . . .     |||..   
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

E---------VTFGPFTITLIDEEHYDEISCRTMELRSTTsKSRVQTVYQLQLTTWPiTSEICASAISFMEL-HR---RAMVWNEANAKDAPIMVHCKDG
|           || ... |..  .  |    | ..| |  .   . . | |   ||   .|   .  | .| |    |      .. .. ||.|||  |
eqfsiygngnevfgtysvelveviqdpereiitrnirltf.egetrditqyqyegwp.dhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

EGATGTFCSLSSVLERLN
 | |||||.   ....|.
vgrtgtfctavimmkkld
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1839-2075 6.7e-50 165.2 In-house 58-287 (319) alignment 
Range on Protein: 1839-2075
Range on HMM: 58-287/319.0
NSMNVHKNRYHDKLPTDKSRPYLI-TEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNglaskDQSMAEYWPDESESEV
   |  |||. . |. ||..  |  .. |....||||||. || .||... .| ||.||. ||||....|..|||..|       .  ..||| . . . 
ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivike

TFGPFTITLIDEehYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPITSeICASAISFMELHRRAMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLE
  .   .....|   .|   | .||   . .  .. . |  .  ||       ... .| | ..    .. . . |.|.|||  | | ||..  |  .|.
erfkvkvdsvee..taeyvvrdielsedgkekdirkitqfhflGwpdvG.vpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlld

RLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVL
|.. || |||..  . .|  |   | .|.|| ||.| |
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1840-2075 1.3e-49 164.3 In-house 23-251 (284) alignment 
Range on Protein: 1840-2075
Range on HMM: 23-251/284.0
SMNVHKNRYHDKLPTDKSRPYLI-TEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNglaskDQSMAEYWPDESESEVT
  |  |||. . |. ||..  |  .  |....||||||. || .||... || ||.||. ||||....|..|||..|      ..  ..||| . . .  
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivikee

FGPFTITLIDEehYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPITSeICASAISFMELHRRAMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLER
 .   .....|   .|   | .||   . .  .... |  .  ||       ... .| | ..    .. . . |.|.|||  | | ||..  |  .|.|
rfkvkvdsvee..seeyvvrdielsedgkekdirkirqfhflgwpdvg.vpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

LNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVL
.. || |||..  . .|  |   | .|.|| ||.| |
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1840-2080 3.4e-44 146.0 In-house 26-269 (274) alignment 
Range on Protein: 1840-2080
Range on HMM: 26-269/274.0
SMNVHKNRYHDKLPTDKSRPYLITEVEN--GTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQ-SMAEYWPDESES
. . .||||.. || ..||  | .|  .   ..|||| .. || . . ... || |||||| ||||...  ... |.||  |  ...   |.|.||. . 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

EV--TFGPFTITLIDEEHYDEISCRTMELRSTTSksrVQTVYQLQLTTWPITsEICASAISFMELHRRAMV-WNEANAKDAPIMVHCKDGEGATGTFCSL
|.  ..| . |.  .  . .. | |.. |.....    ..|.    | || . .   .| ....| .      .|.||| ||..|||  | | || | . 
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdh.ksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

SSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLD
|  . .|. |. |||..    .|  | | | .  |||.|| .| ||| 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1840-2075 4e-10 33.8 In-house 45-275 (303) alignment 
Range on Protein: 1840-2075
Range on HMM: 45-275/303.0
SMNVHKNRYHDKLPTDKSRPYLiteveNGTNYINASFLPGYTKKDMFLgTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQSMAEYWPDESESEVTF
  |..|||. | .  |.|.  |       . || ||.|   ..|   | || ||. |  |||... . |.  ...|   .  |.   ..   . .  . |
vknmdknrfvdvicldhskvkl.....sdssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GPFTITLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPITSEICASAISFMELHRRAMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLERL
   .| . .  . .     .. . | .  .    ..  .  .|| .|  . ..  |.    .        ..  | .     | | .|||. . .    |
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

NVEK-LVDVFQACKRVRAIRRGAVASLAQYEFIHSVL
  |.  .|. .  . ||  |  ||  |.|. .....|
hseqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1840-1890 9.2e-06 19.8 In-house 46-94 (95) alignment 
Range on Protein: 1840-1890
Range on HMM: 46-94/95.0
SMNVHKNRYHDKLPTDKSRPYLITEVEngTNYINASFLPGYTKKDMFLGTQ
  |. |||. . .| | .|  | |  .  ..|||| |. ||..|. .. .|
eanipknrflnifpydatrvvlttkrd..sdyinacfvdgyarkncyiaaq
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1841-2080 8.2e-36 118.4 In-house 19-265 (270) alignment 
Range on Protein: 1841-2080
Range on HMM: 19-265/270.0
MNVHKNRYHDKLPTDKSRPYLITE-VENGTNYINASFLPGYTKK-DMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQSM-AEYWPDESESEV
 . . |||.| ||. ..|  | ..  .. |.|||| ...|....   .. ...|||.|. .|||.... | ..|.|. ||  | ..  . ||| |....|
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

TFGPFTITLIDE--EHYDEISCRTMELRSTTSKSRVQtvyQLQLTTWP-----ITSEICASAISFMELHRRAMVWNEANAKDAPIMVHCKDGEGATGTFC
..   .|. . .  |. .    . ..|... .. |.      . .|||      ...   |. . ... |    ...  .|  |..||| .| | |||. 
kledgkikvlalseekeegyiltrlrleekgeerrlv...HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

SLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLD
 |  ... |. .| ||| .  ...|  |   |    ||||.. ....| .
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1841-2072 4.6e-30 99.3 In-house 55-276 (290) alignment 
Range on Protein: 1841-2072
Range on HMM: 55-276/290.0
MNVHKNRYHDKLPTDKSRPYLiTEVENGtNYINASFLPGytKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQS-MAEYWPDESESEVTF
 ...||||.|    ||.|  |  .  .| .|. | .. |   | ||. || .| .|| |.||.| . |...|.||  |  . ..  ..|.|...   .||
tefkknrykdvvcndktrvil.kdGydG.dyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GPFTITLIDEEHYD-EISCRTMELRSTTSkSRVQTVYQLQLTTWPITSeICASAisfMELHRRAMVWneaNAKDAPIMVHCKDGEGATGTFCSLSSVLER
| .|..   |.. | .|  .|. .|   |  .   .. |.. .||  | .  |.   . | |   .         |..|||  | | |||| ..   |. 
Geitvlcseeddkdaniikktlsvrdkds.Gkehklkhlkikswpdks.valst...lallrtlril...rkasGpvvvhcsaGiGrtGtfvaievglqi

LNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIH
|   | .|. . .. .|  | ..|    ||  . 
lldGkeldlldlvralrnsrlnsvqvdiqylalv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1841-2079 4.7e-23 76.6 In-house 34-270 (285) alignment 
Range on Protein: 1841-2079
Range on HMM: 34-270/285.0
MNVHKNRYHDKLPTDKSRPYLItevENGTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASK-DQSMAEYWPDESESEVT
 |   ||| |    ...|  |    .   .|| ||..    | .  .. || |||.|. |||..... ||. ..||  |     .  | |.|..    | 
anpdlnryadvrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

FGPFTITLID--EEHYDEISCRTMELRSTT-SKSRVQTVYQLQLTTWPITsEICASAISFMELHRRAmvwNEANAKDAPIMVHCKDGEGATGTFCSLSSV
|| . ||| .  ||        .. .  |  . |    . ..|.  ||        |  ..||..     .. | |. || |||  | | | ||  .   
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdq.lapedarpmielykwv...kkvnpkekpicvhcsagvgrtatfvgidya

LERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
  |.  .  .....  . .||.|  || |  |. |.. ||  |.
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
Y_phosphatase Protein-tyrosine phosphatase 1842-2075 5.8e-61 201.3 Pfam-A 1-233 (235) alignment 
Range on Protein: 1842-2075
Range on HMM: 1-233/235.0
NVHKNRYHDKLPTDKSRPYLiTEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASK-DQSMAEYWPDESESEVTFG
| .||||.| || ||.|  | .. |. ..||||... ||..| .|. || ||..|..||||.|...|...|.||. |  | .. .|.|||.|.| ..|.|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PFTITLI-DEE-HYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNeaNAKDAPIMVHCKDGEGATGTFCSLSSVLER
 ....|  .|. . .|.  |..||......|. ..|.||..|.||  ... .|. |...| |.   ..  .||..|..|||..| | ||||..|. .||.
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

LNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVL
|. |. |||.|..|..|. |.|.| ||.||.|.. ..
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1842-2075 5.8e-61 201.3 In-house 1-233 (235) alignment 
Range on Protein: 1842-2075
Range on HMM: 1-233/235.0
NVHKNRYHDKLPTDKSRPYLiTEVENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASK-DQSMAEYWPDESESEVTFG
| .||||.| || ||.|  | .. |. ..||||... ||..| .|. || ||..|..||||.|...|...|.||. |  | .. .|.|||.|.| ..|.|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PFTITLI-DEE-HYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPiTSEICASAISFMELHRRAMVWNeaNAKDAPIMVHCKDGEGATGTFCSLSSVLER
 ....|  .|. . .|.  |..||......|. ..|.||..|.||  ... .|. |...| |.   ..  .||..|..|||..| | ||||..|. .||.
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

LNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVL
|. |. |||.|..|..|. |.|.| ||.||.|.. ..
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1842-2074 1.2e-32 108.1 In-house 3-234 (237) alignment 
Range on Protein: 1842-2074
Range on HMM: 3-234/237.0
NVHKNRYHDKLPTDKSRPYLiTEVENGTNYINASFLPGYTK-KDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQ-SMAEYWPDEsESEVTF
|  |||| .    |.||  |     .|..||||..| |.      .. .| || ..  |||..|.. | | |.|| ||  ...    .|||.  .   ..
nkiknrygnivaydhsrvvl.kgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaay

GPFTITLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPITsEICASAISFMELHRRAMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLERL
| .|..|  .|.. . . |.. |   ...  |. ..| |.|.||    .   . ... . .. .  ..  .. .| ..||  | | || |  . ..| . 
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdr.gvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

NVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSV
. .|.||...  . .   |   . .  || ||| .
kekkvvdiynyvysieedrpyiiqtkdqyvfihqt
0041856 (Phosphotyrosine protein) phosphatases II 1842-2078 6.5e-32 106.0 In-house 1-170 (182) alignment 
Range on Protein: 1842-2078
Range on HMM: 1-170/182.0
NVHKNRYHDKLPTDKSRpylitevenGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNglaskdqsMAEYWPDESesevtfgp
|..|||| | || | ||         . .||||... |. . . |. ||.||..|| ||.|.. ...|.||..|.           |||..         
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell........

ftitlideehydeiscrtmelrsttsKSRVQTVYQLQLTTWPITSeiCASAISFMELHRRamvwneanaKDAPIMVHCKDGEGATGTFCSLSSVLERlnv
                          .  . ....|.   .....    ....|.|  ..         .. |. |||. | | |||.. .  ....   
..........................erlgiqylylpwpDhgvpd..ldelldfieevle.........eggpvlVHCsaGvgRtgtlvaaylmkkl...

eKlVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLY
 . |....| | ||  | |.| .. || |.. .|...
.g.vsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1842-2079 7.9e-17 55.6 In-house 51-285 (302) alignment 
Range on Protein: 1842-2079
Range on HMM: 51-285/302.0
NVHKNRYHDKLPTDKSrpyLITEVENGTNYINASFL--PGYTkKDMFLgTQTPLPNTV---GDFWRLVFDYKISTIIMLNGLASKDQSMAEYWPDESESE
|..||. .|    |.    |.   ..  .|.||| .  |  | . ..| .| |  ...    .|||.||. || .. .| |    .... |..| .|.. 
nlkknqsedvpildsn...lvkleaepdsyvnaskvevPelt.rsiil.aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdy

VTFGPFTITLIDEEHYDEIS-CRTMEL-RSTTSKSRVQTVYQLqlTTWPITSEICASAISFMELHRramVWNEANAKDAPIMVHCKDGEGATGTFCSLSS
...| . .     |. .|     ..|.     | | . .|| |  | |. ..     |    . .    |...    |.....  | | |  |.| .|  
keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvl..tnWkqkkvpvkyaeliktaak...vfakkikadentvivSknGaGRagafltlav

VLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYL
..|.|. .| . . .  | .|. |  || || || ... .| ||.
aveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1842-1938 8.2e-11 36.2 In-house 47-159 (350) alignment 
Range on Protein: 1842-1938
Range on HMM: 47-159/350.0
NVHKNRYHDKLPTDKSRPYLI---------TEVENGTNYINASFLP----GYTKKDMF--LGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKD-QSM
   ||||.. || ..||  |              .. .||||..|     .   .  |  . ||.|||.|| ||.....  |.  |..|. .   . . .
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

AEYWPDESESEVT
 .||.. | ...|
yrYWqegsyddit
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1842-1928 5.3e-08 26.8 In-house 37-128 (347) alignment 
Range on Protein: 1842-1928
Range on HMM: 37-128/347.0
NVHKNRYHDKLPTDKSRPYLITE------VENGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGlASKDQSMAEY
.. ||| .|.  .|..|  |  |       ..  .||||| .     .  .. || |||.|| |||..|.  |.. .. .     ||... |.
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife.pikdeaieef
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1842-1928 7.9e-06 19.6 In-house 34-120 (332) alignment 
Range on Protein: 1842-1928
Range on HMM: 34-120/332.0
NVHKNRYHDKLPTDKSRPYLITEvENGTNYINASFLPGYTKKDMFLGTQTPLPN-TVGDFWRLVFDYKISTIIMLNGLASKDQSMAEY
|.  ||       |.||  |  . .   .. |||.. ||.||  .. .|.|. . |   |||.| . | | |...  .  |..  | |
nmdmnriphlycfdhsrvelapq.dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapy
subfamily_CG42327_pd Subfamily CG42327 1843-1996 9.6e-14 45.8 In-house 29-184 (319) alignment 
Range on Protein: 1843-1996
Range on HMM: 29-184/319.0
VHKNRYHDKLPTDKSRPYLITEV-ENGTNYINASFLPGYTKK-DMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKD-QSMAEYWPDES--ESEV
  |.|. . .|  ..|. |     .. ..|..||.. || .    ....|..| ..  ||||.|.. .  .|. |  |  .  .  |||.| .   ... 
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

TFGPFTITLIDEEHYDEISCRTMELRST-TSKSRVQTVYQLqltTWPiTSEICASAISFM
..| . .|| . |  |.    |. |.    ..||  | |      |.  .|. |.  ...
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy...kwl.eaevPaeeaali
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1846-2086 2.6e-10 34.5 In-house 47-283 (312) alignment 
Range on Protein: 1846-2086
Range on HMM: 47-283/312.0
NRYHDKLPTDKSRPYLITEvENgtNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKD-QSMAEYWPDE------SESEVT
||| .    |. |  |  . ||   || | |.   || . |. ||.|| ||.  ||.|..    ..||.| |.     .  |.|  |        .  | 
nrypniqcwdrgrftlagd.en..fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvy

FGPFTITLIDEEHYDEISCRTMEL--RSTTSKSRVQtvyQLQLTTWPITS--EICASAISFMelhrramvwNEANAKDAPIMVHCKDGEGATGTFCSLSS
    |   |     | |. | . .  ..|  .|...   . | ..||     . | .|  ..            .    |.. ||  | | |||.. . |
teycteieiggkskdkithrvlkvvvkatgqeskln...hyqwaswpdhgmpdscdtalrll.........savkkdkkpviahcsagvgrtgtlalies

VLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSYDIYE
..  |   .  .| ..   .|  |  .|  ..|| .   ..  .| |  .|.
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglyk
0046846 (Phosphotyrosine protein) phosphatases II 1859-2080 1.7e-24 82.0 In-house 2-174 (176) alignment 
Range on Protein: 1859-2080
Range on HMM: 2-174/176.0
PYLITEVENGTNYINASFLPGYtkkdMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQ-SMAEYWPDESESEVtfgpftitlideehydeisc
.....  ... .||||... |.    ... || |||.|. ||........|.....|. .  ... ... |||.. . ..                    
rlrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................

rtmelrsttsksrvqtvyqlQLTTWPITSEICASAISFMELHRRAMVWNEANakdAPIMVHCKDGEGATGTFCSLSsvleRLNVEKLVDVFQACKRVRAI
                    |   .|.    . .   ..|| .    . ...    |. |||. | | |||.. .      |  || ..|..| ..||..
....................qylhlpwpDhgvpdlelllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreq

RR-GAVASLAQYEFIHSVLRLYLD
|. ||| . .||.|.. ...|.|.
RplgavqtpeQyrflyefellllk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1862-1984 1.6e-12 41.9 In-house 7-123 (130) alignment 
Range on Protein: 1862-1984
Range on HMM: 7-123/130.0
ITEVEnGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDqsmaEYWPDESESEVTFGPFTITLIDEEHYDEISCRTME
.. .. | .||||||.    .   .| || || .|  |||.....  .  ...|  .  .|    |||||    |      ..|| | . ...|    .|
vsrlq.gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefknikasnle

LRSTTSKSRvQTVYQLQLTTWPI
  |   .|  |..  .|.. || 
iesdlnesh.qaltmfqisnwps
0044763 (Phosphotyrosine protein) phosphatases II 1865-2078 5.6e-17 57.4 In-house 14-170 (178) alignment 
Range on Protein: 1865-2078
Range on HMM: 14-170/178.0
VENGTNYINASFLPGYtkkdMFLGTQTPlpntvGDFWRLVFDYKISTIIMLNGLASKD-QSMAEYWPDESEsevtfgpftitlideehydeiscrtmelr
 .... |||||.  ..    ..||.. |      |...|. ...|..|..|..      ... .|||.| .                             
glersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............................

sttsksrvqtvyqLQLTTWPIT-------SEICASAISFMELHRramvwneaNAKDAPIMVHCKDGEGATGTFCSLSSVLERlnveKLvDVFQACKRVRA
             .|   .||        .|..  .. |.| ..        . |. |. |||. | | .||.. .  ....    .| ....| ..||.
.............iqylhipipDhgvpdllehflefvefieeal........dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvre

IRRgAVASLAQYEFIHSVLRLY
 |. .| .  |..... . . .
rRp.ivpnpgqlrqLyefelrl
0043147 (Phosphotyrosine protein) phosphatases II 1867-2072 3.3e-25 84.2 In-house 3-154 (172) alignment 
Range on Protein: 1867-2072
Range on HMM: 3-154/172.0
NGTNYINASFLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLaskdqsmaeywpdesesevtfgpftitlideehydeiscrtmelrSTT
.|..|||||.|..| . | |. || ||.||. ||||.. ...|..|..|..|                                              ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

SKSRVQTVYQLQLTTWPITSEIcaSAISFMELHRRAMVWNeANAKDAPIMVHCKDGEGATGTFCSLSSVLerLNVeklvDVFQACKRVRAIRRGAVASLA
 .  .....|.. . ||  .    ..  ..|. .    .  |. .. |. |||. | | |||.. .  .|  |..    ....| . ||. |.||| .  
pellerlgiqylylpwpDhgvp..llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml..lgl....sleeavalvrekRpgavqnps

QYEFIH
|| |..
qyrfly
0051429 (Phosphotyrosine protein) phosphatases II 1868-2082 3.3e-36 120.7 In-house 3-228 (272) alignment 
Range on Protein: 1868-2082
Range on HMM: 3-228/272.0
GTNYINASFLPGYTK---KDMFLGTQTPLPNTVGDFWRLvFDYKISTIIMLNGLASKDQSM-AEYWP----------DESESEVTFGPFTITLIDEEHYD
 ..||||....||..   ..... .. |||.|. |||||  ...|.||..| ..  ...     |||          |.|. ....| ...||. ||...
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

EISCRTMELRSTTSKSRVQTVYQLQLTTWPITSEICASAISFMELHRRamvwneanakDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVD-------
 . .|...|. . | . . .|..|. | ||  .    . ....|| ..          . |..|||. | . |||.. |  .|.... |  ||       
dyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld..........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VFQACKRVRAIRRGAVASLAQYEFIHSVLRLYLDSY
 ...| ...||.|.||| . .||.|.. .|. .|.|.
yleeaveelraqrpgavqteeqylflyeallellrsl
0036282 (Phosphotyrosine protein) phosphatases II 1868-2073 3.5e-25 84.1 In-house 1-164 (174) alignment 
Range on Protein: 1868-2073
Range on HMM: 1-164/174.0
GTNYINASFLPGYTKKDMFLGTQTPLPntvgdFWRLVFDYKISTIIMLNGLASKD-QSMAEYWPDesesevtfgpftitlideehydeiscrtmelrstT
|..|||||.| ..   . .. .| ||.     ||.......|.|..||. .  ..   .  |||.                                  .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................l

SKSRVQTVYQLQLTTWPITSEICASAisFMELHRRAMVWNEAnAKDAPIMVHCKDGEGATGTFCSLSSVLERLNvEKLVDVFQACKRVRAIRRGAVASLA
... .....|.. . ||  ..   |   . |. ...  . .   .. |. |||. | | |||.. .  .| .|  |.|||...  ...|  | |.| .  
redlerlgiqylylpwpDhgvpdlsi..llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QYEFIHS
||.|.. 
Qyrflyy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1868-1936 3e-07 24.1 In-house 89-160 (349) alignment 
Range on Protein: 1868-1936
Range on HMM: 89-160/349.0
GTNYINASFL--PGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGlaSKDQSMA---EYWPDESESE
  .|||| .|  . .. .  .. || ||| || ||....   ..  .. ||   .|..|.     || . | |.
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnd..dkelslekcdiywqelsysn
0051082 (Phosphotyrosine protein) phosphatases II 1869-2073 4.1e-21 70.6 In-house 3-147 (151) alignment 
Range on Protein: 1869-2073
Range on HMM: 3-147/151.0
TNYINASFLPGYtkkdmFLGTQTPLPntvgDFWRLVFDYKISTIIMLNGLASKDqSMAEYWPDESesevtfgpftitlideehydeiscrtmelrsttsk
..|||.|.. |.     .. .. ||.    ||..|. ...|.||..|...   .  ..||.|...                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................

srvQTVYQLQLTTWPITS--EICASAISFMELHRRamvwneanAKDAPIMVHCKDGEGATGTFCSLSSVLERlnveklVDVFQACKRVRAIRRGAVASLA
    .|...... || ..  .. .....|.|| ..         |. |. |||. | | |||.. |  .|..      |....| . .|..| |.| .  
...ievlhipildwpdpglplsfdavleflellld........kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

QYEFIHS
|. |.. 
qflfqlf
0049260 (Phosphotyrosine protein) phosphatases II 1876-2073 3.8e-22 74.0 In-house 1-144 (152) alignment 
Range on Protein: 1876-2073
Range on HMM: 1-144/152.0
FLPGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQ-SMAEYWpdesesevtfgpftitlideehydeiscrtmelrsttsksrvqtv
|..|| .. .|..|| |.|||. ||||.. ...|.||.||. |  ..   ...|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

yqlQLTTWPITSEICASAISFMELHRRAMVWNeANAKDAPIMVHCKDGEGATGTFCSLSSVLerlnveKLVDVFQACKRVRAIRRGAVASLAQYEFIHS
   |   .|.    . . . ...   ... .  |  |. |. |||. | | |||.. .  .|      . |....| ..||. | ||| .  |..|.. 
...qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1878-2074 9.4e-37 121.3 In-house 230-433 (440) alignment 
Range on Protein: 1878-2074
Range on HMM: 230-433/440.0
PGYTKKDMFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLASKDQSMaeYWPDESESeVTFGPFTITLIDEEHYDEISCRTMELRsttSKSRVQTVYQL
 ||.||. |. || ||  || |||||| ||.|||||||| |  |  |.  ||| .. | |||||||.     |  . .  ||.||.    |  |. . |.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsi..ywpvntrs.vtfgpftvghkgsenmnrvkvrtlelk...ykeevheirqf

QLTTWPI--------TSEICASAI-SFMELHRRAMVWNEAN----AKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVAS
.. |||         . | |  |.  .|.  |.  .   ..        ||.|||  |   .| ||..  .||.|| .  .||||  . .|  |   | .
evqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvpt

LAQYEFIHSV
|..| . . .
ltdyllcykl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1885-2073 4.4e-22 73.2 In-house 6-198 (199) alignment 
Range on Protein: 1885-2073
Range on HMM: 6-198/199.0
MFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLA-SKDQSMAEYWPDESESEVTFGPFTITLIDEEHYDEISCR-TMELRSTTSKSRVQTVYQLQLTTW
 .. || || .|. |||..|..     |.|.|     |.  .. |||    .   .| ...|        . .    .   .||.    . . . |.|.|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PI-TSEICASAISFMELHRRaMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVE--KLVDVFQACKRVRAIRRGAVASLAQYEFIHS
   |.   |  . |.   |  .  .  . ||||..||| ||.| || | .|   .   .     .||.|. .||.|  | | ..|| .|.||. 
kekttpnvalfvgfvvasre.vskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1885-2073 4.5e-22 73.2 In-house 5-197 (198) alignment 
Range on Protein: 1885-2073
Range on HMM: 5-197/198.0
MFLGTQTPLPNTVGDFWRLVFDYKISTIIMLNGLA-SKDQSMAEYWPDESESEVTFGPFTITLIDEEHYDEISCR-TMELRSTTSKSRVQTVYQLQLTTW
 .. || || .|. |||..|..     |.|.|     |.  .. |||    .   .| ...|        . .    .   .||.    . . . |.|.|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PI-TSEICASAISFMELHRRaMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVE--KLVDVFQACKRVRAIRRGAVASLAQYEFIHS
   |.   |  . |.   |  .  .  . ||||..||| ||.| || | .|   .   .     .||.|. .||.|  | | ..|| .|.||. 
kekttpnvalfvgfvvasre.vskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1887-2037 4.3e-08 27.5 In-house 39-173 (255) alignment 
Range on Protein: 1887-2037
Range on HMM: 39-173/255.0
LgtqtplpnTVGDFWRLVFDYKISTIIMLNGLAS-KDQSMAEYWPDESESEVTFGPFTITLIDeeHYDEISCRTMELRSTTS-KSRVQTVYQLQLTTWPI
|        ||  |.. .   | ....||  .|  . .   .|.| | .    .   ..|  .     ..  ||.|. || . | . .||   . . |. 
l........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWie

TSeICasaisfmELHRRAMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLE
            || |  .    .  .  ...|||  | | . .|    .|  
kn.aP.......elareilnilkvvrdsksvvvhCstGiGrsaafvlaelvyq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1889-2070 4.5e-12 40.0 In-house 96-279 (302) alignment 
Range on Protein: 1889-2070
Range on HMM: 96-279/302.0
TQTPLPNTVGDFWRLVFDYKISTIIMLNGLA-SKDQSMAEYWPDESESEVTFGPFTITLIDE-EHYDE------ISCRTMELRSTTSKSRV-QTVYQLQL
  .|  .|.  .| |. .|... .. | ..  .... .|||. |. . |..|| .|.. ..  .. .|      .   |.|.. .  |..| .||  |. 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TTWPITSeICASAISFMELhrraMVWNEANAKDapIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEF
..||      . | . ...    . . |.  |.  ..|||  | | |||. ..   ..    .|  |. .  . ||. | ||| .  |  .
sawpdhG.apkeaytaldi....lkfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1889-2079 4.7e-12 40.6 In-house 65-259 (290) alignment 
Range on Protein: 1889-2079
Range on HMM: 65-259/290.0
TQTPLP-------NTVGDFWRLVFDYKISTIIMLNGLASKDQS-----MAEYWPDESESEVTFGPFTITLIDEEHYDEISCRTMELRSTtsKSRVQTVYQ
||.|.         |. .|| .. . |.  ..||     |..       |.| |.. . |..|. .|.   . |. |..  |.....    . .  ||  
tqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd..deeeftvtH

LQLTTWPiTSEICASAISFMELHRramvwnEANAKDAPIMVHCKDGEGATGTFCSLSSVLERLN-VEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVL
 .|  |  ....  . .....| .        .|...|..|||.||     .. ..      .   .. | . .. | .|  |  |. |  .. |.  ..
sllkgWn.klnvqedtktllsliq......kvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi

RLYL
 |..
vlla
subfamily_hpo-7_pd Subfamily hpo-7 1893-2067 1.8e-07 25.3 In-house 43-215 (263) alignment 
Range on Protein: 1893-2067
Range on HMM: 43-215/263.0
LPNTVGDFWRLVFDYKISTIIMLNGLASK-DQSMAEYWPDESESEVTFGPFTITLIDEEHydEISCRTMELRSTTS-KSRVQTVYQLQLTTWPITSEICA
| .|.  |.. .   | ....||   . .  .   .|.| | .    .   ...  .  .  ..  .| || || . | ...|| . . . |. . .   
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

sAISFMELHRramvwneANAKDAPIMVHCKDGEGATGTFCSLSSVLE----RLNVEKLV--DVFQACKRVRAIRRGAVASLAQ
 |.. ... .       .. .  ...|||  | | .  |    .|       |.  . |  |  .  . .|  |..|.    |
.areilnilk.......varnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmq
0048076 (Phosphotyrosine protein) phosphatases II 1928-2078 8.2e-12 40.5 In-house 2-142 (145) alignment 
Range on Protein: 1928-2078
Range on HMM: 2-142/145.0
YWPDESESEVTFGPFTiTLIDEEHYDEISCRTMELRSTTSKSRVQTVYQLQLTTWPI-----TSEICASAISFMELHRRAmvwneanakDAPIMVHCKDG
|||.|    . .|... | .| |.. .   .|    ... .  .....|.. . ||       .|.  ... |.| ....         . |. |||. |
ywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.........ggpvlVHCsaG

EGATGTFCSLSSVLErlnvEKlVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLY
 | |||.. .  .|.    .. |....| ..||. |.||| .  |..|.. ... .
vgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1958-2081 1.9e-15 51.2 In-house 264-387 (392) alignment 
Range on Protein: 1958-2081
Range on HMM: 264-387/392.0
RTMELRSTTSKSRVQTVYQLQLTTWPI-TSEICASAISFMELHRrAMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRA
|.  |. . |     || | |.  ||   |.  . | |.. | | |.     . |.  |.|||  | | || ||.    . ..   . ||.||. | .||
rskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllklir.avkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilra

IRRGAVASLAQYEFIHSVLRLYLDS
 |   | .  .| |.. | | || .
drmqfvqteeeyafvydvireylht
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1969-2039 9.3e-06 19.2 In-house 215-292 (349) alignment 
Range on Protein: 1969-2039
Range on HMM: 215-292/349.0
SRVQTVYQLQLTTWPITSEICAsAISFME-LHRRAMVWNE-------ANAKDAPIMVHCKDGEGATGTFCSLSSVLERL
..   ..|||.  |. .| .    ||... |. .  . ..        ... ....|||  | | ||... | ..|. |
ekPyellqlqvknwldlsllln.PisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsil
PTPc_DSPc_SM00012 1973-2075 8.6e-20 66.3 In-house 1-103 (105) alignment 
Range on Protein: 1973-2075
Range on HMM: 1-103/105.0
TVYQLQLTTWPITsEICASAISFMELHRRAMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVE-KLVDVFQACKRVRAIRRGAVASLAQYEFI
||.... |.|| . ..  .. |..|| |  . ....... .|..|||..| | ||||. |. .|..|. | | ||.|| .|..|  |.|.| ...|| |.
tvkhyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

HSVL
. .|
yral
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1973-2052 6.1e-07 23.5 In-house 216-303 (350) alignment 
Range on Protein: 1973-2052
Range on HMM: 216-303/350.0
TVYQLQLTTWPITSEIC--ASAISFMEL-----HRRAMVWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLE-RLNVEKLVDVFQACK
 |||||.  |.  | .    | .. .|                ||. .||.|||  | | |||...| |.|.  . .|.| . ..  .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkld
0048179 (Phosphotyrosine protein) phosphatases II 1975-2073 3.5e-10 35.3 In-house 50-139 (144) alignment 
Range on Protein: 1975-2073
Range on HMM: 50-139/144.0
YQLQLTTWPITS-----EICASAISFMELHrramvwneaNAKDAPIMVHCKDGEGATGTFCSLSSVLerlnVEKlVDVFQACKRVRAIRRGAVASLAQYE
.|.. . ||  .     |.. ... |.| .          ... |. |||. | | |||.. .  ..    ... .....| ..||..| ||| .  |..
iqylhlpwpDhgvpdllellleflefieea.........leeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlr

FIHS
|.. 
fLle
subfamily_CG42327_pd Subfamily CG42327 2004-2078 4e-10 33.9 In-house 239-314 (319) alignment 
Range on Protein: 2004-2078
Range on HMM: 239-314/319.0
VWNEANAKDAPIMVHCKDGEGATGTFCSLSSVLERLNVE-KLVDVFQACKRVRAIRRGAVASLAQYEFIHSVLRLY
  .  . .  |..||| || | ||.  .    ...|.   . ||. |    ||  |  || .  |||||. ||  |
srsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2016-2075 5.4e-10 33.5 In-house 2-61 (69) alignment 
Range on Protein: 2016-2075
Range on HMM: 2-61/69.0
MVHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVL
.|||  | | |||| ..   . |.  |||||.|   . .|  |   |    .| |||  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2017-2075 8.1e-10 32.9 In-house 2-60 (69) alignment 
Range on Protein: 2017-2075
Range on HMM: 2-60/69.0
VHCKDGEGATGTFCSLSSVLERLNVEKLVDVFQACKRVRAIRRGAVASLAQYEFIHSVL
|||  | | |||| ..   . |.  |||||.|   . .|  |   |    .| |||  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal