Gene SpurPTPRA-like-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP108_AA protein Get Run
SpurP108_AA_2-251 phosphatase_domain Get Run
SpurP108_AA_264-527 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-278 1e-174 575.3 In-house 49-319 (319) alignment 
Range on Protein: 2-278
Range on HMM: 49-319/319.0
PLATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTkciedgKDKCSQ
.||.....||..||||||.|||.|.|...|||....|.|.|||||||.|.|||..||.||||||.||||.|||||||||||||||.||      ||||||
nladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWPNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYI
|||.|.|||..|||||.|||.||||||.|...|||||||...|.|||||||||||.|.|||||..|.|.|.|||||||.||||||||||||||||||.||
ywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyi

VIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDD
|.|..||.||.|||||.|||..|.|||||||||..|||.||..|||||||||||||||||||||...||||||||||
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnksdfddd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-279 3.9e-171 563.0 In-house 13-284 (284) alignment 
Range on Protein: 2-279
Range on HMM: 13-284/284.0
PLATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTkciedgKDKCSQ
........||..||||||...|.|.|...|||....|.|.|||||||...|||..||.||.|||.||||.|||||||||||||||.||      ||||||
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsq

YWPNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYI
|||.|.|||..|||||.|||.|..|||.|...|||||||...|.|.|||||||||.|.|||||..|.|.|.|||||||.||||||||||||||||||.||
ywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

VIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDDL
|.|..||.||.|||||.|||..|.|||||||||..|||.||..||||||||||||||.||||||...|||||||||||
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnksdfdddl
subfamily_PTPN9_pd Subfamily PTPN9 2-248 2.5e-76 251.5 In-house 30-288 (297) alignment 
Range on Protein: 2-248
Range on HMM: 30-288/297.0
PLATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQ
.  |...|.|. |  |||| ... ||.|||.|. .|. | ||||||..|.||. .. |||.||| ..| .|||||.|| .. .||| |...| |. ||.|
veGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgq

YWP--NKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEdGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKM----N-------HRANIVV
|||  .. ....| ..|.  .| |. .|..|......  |.  .|..| | ||.|||.| |.  . .. ... ||.  ...            .   |||
yWpleeessaefgdlsvsnveveeeedykvrvleikn.vkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivv

HCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|||||.|||||.| .|  |. .... .||. . .. .|.||   .|   || | ..|.||
hcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0050432 (Phosphotyrosine protein) phosphatases II 3-250 3.1e-97 320.9 In-house 57-299 (308) alignment 
Range on Protein: 3-250
Range on HMM: 57-299/308.0
LATMNHSNLPPNKDKNRYINIIAYDHTRVKLkptdGiEGSDYINASYVNGY--QSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCS
| ......|| ||||||| .|..|||.||||    . |||||||||||.||   .| ||||.|||..||.||||||.||.|...||||||..|.|. || 
lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekca

QYWPNK---GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKEtGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTskmnHRANIVVHCSAGVGRT
||||..   |...||.|.|.. |... ..|..| ..|.  |..   | .|.||...||||| |..|.... ....||.         .||||||||||||
qYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRt

GTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEH
||.|..| .|.....|. ||... .. .|.||.  ||.. ||.|...||||  
GtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0036941 (Phosphotyrosine protein) phosphatases II 3-251 9.1e-94 309.3 In-house 28-278 (297) alignment 
Range on Protein: 3-251
Range on HMM: 28-278/297.0
LATMNHSNLPPNKDKNRYINIIAYDHTRVKLkptDGiEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQY
| ......|| |..|||| .|..||||||||   |. |||||||||||.||. . ||||.|||..||.||||||.||.|...|||||...|.|. || ||
lgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WPNK--GVIKYGRFKVKMDSVTE--TAEYVIRSFQLSEDGKEtGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTG
||..  ....||.|.|.. ||..   ..|..| ....  |..  .| .|.||..|||||| |..|.... .|..||.  ....    ..|||||||||.|
wpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsg

TYIVIDAMLDMMK---HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
|.|..| ||....   .|..|||..... .|.||.  ||.. || |...||||  .
tfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
subfamily_PTPRA_pd Subfamily PTPRA 4-278 5.6e-101 332.7 In-house 48-323 (330) alignment 
Range on Protein: 4-278
Range on HMM: 48-323/330.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
||.. ..   ||.|||..||. ||..|| | . .|.| |||||||...||.  ||||||||||..|.|||||||||.. .||||||.  |  ..|| |||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PNKGVIKYGRFKVKMDSVTETAEYVIRSFQLS---EDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHraNIVVHCSAGVGRTGTY
|..|.. ||  .|... .|.. .| .| | .    .  .|  .| ..|||| .||| | |  |  |. |.|.|..|  ..     ||||||||||||||.
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGtf

IVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDD
||.||.|...| |..||...|.. .|.||  .||.  || ||. .||| .|.| ... .  .  . |.| ||    |.
ivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdk
0051299 (Phosphotyrosine protein) phosphatases II 4-248 4.2e-99 326.9 In-house 39-284 (288) alignment 
Range on Protein: 4-248
Range on HMM: 39-284/288.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
 |.....|| |..|||| .|..|||.||||...||.||||||||||..||... ||||.|||..||.||||||.||.|...||||||..|.|. || |||
ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYw

PNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDG---KETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmNHRANIVVHCSAGVGRTGTY
|..|...||...|.. |... ..|..| ....  .   ..   | .|.||...||||| ||.|.... ....||.  .  ..   .|||||||||||||.
plggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtf

IVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|..| .|.....|. ||...... .|.||. .||.. || |...||||
ialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0040438 (Phosphotyrosine protein) phosphatases II 4-279 7.5e-98 323.0 In-house 33-305 (317) alignment 
Range on Protein: 4-279
Range on HMM: 33-305/317.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
 |.....|| ||||||| .|. |||.||||.|..|...|||||||||.|.. ..||||.|||..||.||||||.||.....|||||.. |.|. || |||
dtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYw

PNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmNHRANIVVHCSAGVGRTGTYIVI
|......||.|.|.. |..| |....| .... . ..  .| .|.||..|||||| |..|...  ....||.  .  ..   ..||||||||||||.|..
plgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaa

DAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDDL
. ||.....|..||... .. .|.||.  ||.. || |...|||| ..... .. ..... ....| ..  .||. 
ylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvk
0046845 (Phosphotyrosine protein) phosphatases II 4-250 5.2e-96 316.6 In-house 18-274 (284) alignment 
Range on Protein: 4-250
Range on HMM: 18-274/284.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDG-IEGSDYINASYVNGY-----QSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKD
 ......|| |..|||| .|..|||.|||||..|| .|.|||||||||.||      .. ||||.|||..||.||||||.||.|...|||||...|.|. 
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

KCSQYWPNKG-VIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGR
||.||||..| |..||.|.|.. |...   |..| ..|.  | .   | .|.||...||||| |..|.... ... ||.| ....    |||||||||||
kcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgR

TGTYIVIDAMLDMMKHEK---QVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEH
|||.|..| .|.....|.    ||... .. .|.||.  ||.. || |...||||  
tGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 4-248 2.7e-93 307.6 In-house 28-270 (273) alignment 
Range on Protein: 4-248
Range on HMM: 28-270/273.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLkptdGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
 |.....|| ||||||| .|..|||.||||    | .||||||||||.||... ||||.|||..||.||||||.||.|...|||||...|.|. || |||
ltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYw

PNKG---VIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTY
|..|   ...||.|.|.. |... . |..| ..|.  | .   | .|.||..|||||| |....... .|. ||.  .. ..   .|||||||||||||.
pleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtf

IVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|..| .||....|..||... .. .|.||   ||.. || |...||||
ialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0043336 (Phosphotyrosine protein) phosphatases II 4-248 4e-90 297.3 In-house 35-275 (278) alignment 
Range on Protein: 4-248
Range on HMM: 35-275/278.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
 |.....|| ||||||| .|..|||.||||....| ..|||||||||.||. |.||||.||| ..|.||||||.||....||||||.. |.|. || |||
dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYw

PnKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKE-TgqRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmNHRANIVVHCSAGVGRTGTYIV
| .|...||.|.|.. .... . |..| . ..  |.  .  | .|..|.||||||| |. .|... ..|.||.  .  .    ..||||||||||||.|.
p.ggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfia

IDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.. .|.....|. ||... ....|.||   ||.. || |...||||
lyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 4-248 4.2e-89 294.6 In-house 45-302 (307) alignment 
Range on Protein: 4-248
Range on HMM: 45-302/307.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGI-EGSDYINASYV--------NGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIED
 ......|| ||||||| .|..||||||||...||  |.|||||||||        .|| ...||||.|||...|.||||||.||.....|||||...|.
geysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvel

GKDKCSQYWPNKG-VIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAG
|. || ||||..| .. ||.|.|.. |... ..|..| . ..  ...   | .|.||..|||||| |......  .|..||.  .. .    ..||||||
grekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaG

VGRTGTYIVIDAMLDMMKHEKQ---VDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
||||||.|... ||.....|.    ||... .. .|.||   ||.. || |...||||
vgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 4-251 2.1e-83 275.2 In-house 23-273 (278) alignment 
Range on Protein: 4-251
Range on HMM: 23-273/278.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKlkptdgiegsDYINASYVNGYqsPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
 ........ |.||||| .|..|||.|||          |||||||..||  |.||||.|||...|..|||||.||.....|||||...|.|. || |||
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSED---GKETGQRSITQFHFLGWPDHGQPDYP--SPMMCLIKRVRHLTS-----------KMNHRANIV
|..|.. ||.|.|.. |.... .|..| . .       ..  .| .|..|.|.||||| |..|  ...  |....|.  .            ...   ..
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSAGVGRTGTYIVIDAMLDMMkhEKQVDIYNFIHDIRQQRNT-LVQSFVQYFFIHMALLEEHL
||||||||||||..... ||...  |..||... .. .|.||.   ||.. || |....||| .|
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN3_pd Subfamily PTPN3 4-247 3.4e-73 241.0 In-house 31-272 (280) alignment 
Range on Protein: 4-247
Range on HMM: 31-272/280.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDgiEgsDYINASYVN----GYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKC
 .......| | .|||| .|..||.|||||| ..     |||||.|||    . .   ..||.||| ..| .|||.|.|| ..|.|||||  .|.|. ||
laisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

SQYWPNK-GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhrANIVVHCSAGVGRTG
 ||||..   ..||.|.||. .  || .||.| . |..  ... .|.|.|. .| ||||| || .. .. ...|||.| | ..    .|||||||.||||
hqyWPetedeleygefsvkcekedetksyvlrelvlkdk.etkeerkilqlqylaWpdhgvPddsadflefvervrklrsgke..ePvvvhCsaGigrtG

TYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
 .|...  | .. ....| . . .. .|.|| .|||.  || |.  |.|
vlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_PTPRD_pd Subfamily PTPRD 5-289 1.9e-123 408.1 In-house 39-319 (564) alignment 
Range on Protein: 5-289
Range on HMM: 39-319/564.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP
|....| | || |||| ||.||||.||.|....| |||||||||...||... ..||.|||. .|.||||||.||.|.||||||||. | ||.||..|||
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

NKGVIKYGRFKVKMDSVTETAEYVIRSFQLsEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTsKmNHRANIVVHCSAGVGRTGTYIVID
.||  .||...|.. . .| |.|.||.|.| .. |.  .| ..||||  |||||.|... ... ||..||.|. . ...  ||||||||||||||.||||
ekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.pdagPivVhCSaGVGRTGtfivid

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDfDDDLTKLEVEFRRA
|||. .|.||.||||.... .|.|||..||.  ||.||| |.||   .|. .| . .. .  |.|..... | . |.||.||.| 
amlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaevee.dtemtgleleFqrL
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 5-288 1.9e-102 337.6 In-house 37-317 (318) alignment 
Range on Protein: 5-288
Range on HMM: 37-317/318.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP
|  .|. | || ||||.||.|||||||||....| ||||||||.|..||..  ..||||.|  .|.||||||.|| |...|||||.. | ||.|. .|||
tslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP

NKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEdGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhRANIVVHCSAGVGRTGTYIVID
.|| ..||. .|.... .|...||.|.|....  .|  .| . |.|.  |||.| |. .. .. |...|..   | . .  |||||||||||||..|..|
skgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg.agpivvhCsaGvGrtGvfiavd

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNkSDFDDDLTKLEVEFRR
..|. .|.|. ||...... .|.||| .||   || ||. .|||    |...|   |. .  ..| . .| .   |....||.|
illerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre.qdpesgttemdaefqr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 5-286 1.7e-98 324.6 In-house 39-318 (319) alignment 
Range on Protein: 5-286
Range on HMM: 39-318/319.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP
|..... . ||.|||| ||.|||.|||.|.. ||.|||||||||...|||  .||||.|.|..||.||||||.||...|..|||||  | .| |...|||
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp

NKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRaNIVVHCSAGVGRTGTYIVID
.. . .|||. |....  |...|.|| ..| .   |   |....|... ||||. |..   .. |.||.|. ..| ...  ||||||||||||||.||.|
eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg.PivvhCsaGvGRtGtfivld

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKsDFDDDLTKLEVEF
|||. .|.|  .|.....  .| |||..||   || ||. ||||   .|.... . |.    .||..| . |   |.|| ||
amlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaek.vadtgetgleref
subfamily_PTPRG_pd Subfamily PTPRG 5-251 6.5e-92 303.5 In-house 38-288 (563) alignment 
Range on Protein: 5-251
Range on HMM: 38-288/563.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGS-DYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
...||. | || ||||.||.|||..||||.|. |.... |||||.|..|||  ..|||.|||  .|..|||||||| | ..|||.|.  |.|. || .||
daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYW

PNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSE----DGKE-TGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVrhLTSKMNHRANIVVHCSAGVGRTG
|. ....|| ..|.. .   .| | .|.... .    ..|.   .. ..|.|.  ||||| |... | .  .|.    ......   |||||||||||||
PkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaGPivvHcsaGvgrtG

TYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
||||.|..|  ...|..|....|.. || ||| |||.  || |.| ||||  .
tyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
0040439 (Phosphotyrosine protein) phosphatases II 5-248 7.7e-87 286.2 In-house 2-244 (249) alignment 
Range on Protein: 5-248
Range on HMM: 2-244/249.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP
......|| ||||||| .|..|||.||||....| ..||||||||..||.....|||.||| ..|.||||||.||.....|||||.. | |. || ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVID
..|...||.|.|.. ||.. ..|..| ..|.   ..   | ........||||| |....... .|..||.  .. .    ..||||||||||||.|...
lggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
 ||.....|..||... ....|.||.  ||.. || |...||||
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_PTPN14_pd Subfamily PTPN14 5-247 2.1e-63 209.1 In-house 40-293 (300) alignment 
Range on Protein: 5-247
Range on HMM: 40-293/300.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIeGSDYINASYVNGYQSP--DKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQY
... ..|| |..|||. ... |...||.|.||     ..||||| ..   .    ..|.|||| ..|..|||.|.|| . . |||||. .||||.|. .|
llstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPNK----GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRA-------NIVVHCS
.|..      ...|.|||    ....  .. ....|        .|..  . .  ||||| |. .....  ...|. .  |.|.          ..||||
fPkleskkktvefgkfkvttkfsedsdsvittglklkhl.pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

AGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
|||||||  |. | ..  ..|....|| . .. .|.|| .|||.. || |.. .|.
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_PTPRB_pd Subfamily PTPRB 6-248 1.5e-95 314.6 In-house 43-283 (293) alignment 
Range on Protein: 6-248
Range on HMM: 43-283/293.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN
.. ..|. |..|||| ||..|||.||||..... .|||||||.|..||.|| .|||.|||  .|..|||||.|| ..|.|||||...| || || .|||.
vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa

K-GVIKYGRFKVKMDSVTETAEYVIRSFQLSEdgkETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVID
.   . ||  ||.. . .|. ..|||......   |. .|...|.||. ||||| |. ..... ....||. ..| .... ||||||||||||||.| .|
deepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfiald

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
 .|. ...|  |||. .....|..||.|||.  || ||| ..|.
rllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
0039614 (Phosphotyrosine protein) phosphatases II 6-251 1.2e-91 302.5 In-house 48-290 (297) alignment 
Range on Protein: 6-251
Range on HMM: 48-290/297.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGI-EGSDYINASYVNGYQS-PDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKdKCSQYW
. ...|| |||||||..|..|||.|||||| ||  ..|||||||||.||   ..||||.||| ..|.||||||.||.....||||||..|.|. || |||
ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqyw

PNKGViKYGRFKVKMDSVTETAEYVIRSFQLSEDGKEtgqRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVI
|..|  .||.|.|.. .|.. . |..| . .. .|..   | .|.|...|||||| |.... .. ... ||.  .. .    ..||||||||||||.|..
peegg.tygdftvtllkvehldgytvrtlevtnnges...rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaa

DAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
. ||.....|..||... .. .|.||.  ||.. || |...||||  .
ylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_Ptp69D_pd Subfamily Ptp69D 6-269 2.1e-89 294.7 In-house 40-305 (307) alignment 
Range on Protein: 6-269
Range on HMM: 40-305/307.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN
 . |.   |. |||| .|.|.|.||||||.. | | |||||||...||.   ||||||.| ..|..||||||.| .  .||||..  |  ..||..|||.
tkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpi

KGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKET----GQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMnhRANIVVHCSAGVGRTGTYI
   ..||   ||. |  .. .|.||....|. ..|.     .| ..|.|..||.|   |. .  .. ||..||.| ..   |. |||||||||||.|...
edevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvgrsgifv

VIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQL
 .| .|. .| |..|||.....|.|.||| ||||. || |.. |||. . .|..|... |.   ...|
aldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
DSPc_SM00195 6-248 3e-88 290.9 In-house 18-260 (263) alignment 
Range on Protein: 6-248
Range on HMM: 18-260/263.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN
..... . ||.|||| ||. |||||||||.... ||||||||.|..|.... |.||.|||...|.||||||.|| ....|||||.. |.|| ||..|||.
tteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpe

K--GVIKYGRFKVKMDSVTETA-EYVIRSFQLSEDGKeTGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMnhRANIVVHCSAGVGRTGTYIV
.  |  ..|...||. .|...  |...| ..|...||   .|..||... .||||| || ..... |.. |.. .|.    . ||||||||||||||...
esggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvt

IDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|| .|. ...||.||| . .  .|.||  .||.. || ||..|.||
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 6-248 3e-88 290.9 In-house 18-260 (263) alignment 
Range on Protein: 6-248
Range on HMM: 18-260/263.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN
..... . ||.|||| ||. |||||||||.... ||||||||.|..|.... |.||.|||...|.||||||.|| ....|||||.. |.|| ||..|||.
tteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpe

K--GVIKYGRFKVKMDSVTETA-EYVIRSFQLSEDGKeTGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMnhRANIVVHCSAGVGRTGTYIV
.  |  ..|...||. .|...  |...| ..|...||   .|..||... .||||| || ..... |.. |.. .|.    . ||||||||||||||...
esggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvt

IDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|| .|. ...||.||| . .  .|.||  .||.. || ||..|.||
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0037934 (Phosphotyrosine protein) phosphatases II 6-248 2.4e-76 251.8 In-house 2-240 (243) alignment 
Range on Protein: 6-248
Range on HMM: 2-240/243.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLkptdgiEGSDYINASYVNGYqspDKFIAAQGPKDNTLED----FWRMIWEYNCSTIVMLTKCIEDGKDKCSQ
.....|| |..|||| .|..|||.||||      ||||||||......   ...|| ||| ..|.||    ||||.||.....|||||...| |. || |
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPNKGviKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSK------MNHRANIVVHCSAGVG
|||..    ||.|.|.. |......|..| ..|.  . .  .| ....|.|.||||| || |.... ... ||   ..       ..   ..||||||||
ywpgev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTYIVIDAMLDMMkhekQVDIYNFIHDIRQQRNT-LVQSFVQYFFIHMALLE
||||.|... ||...    .||... ....|.||.   ||.. || |...||||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 6-247 2.8e-67 221.7 In-house 20-265 (274) alignment 
Range on Protein: 6-247
Range on HMM: 20-265/274.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEG-SDYINASYVNGYQSPDK-FIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
... ... .. |||| .|.  ...|| |.. .. .  |.|||| |. ||.  .| ..|.|||  ||..||||||.. ... ||||||  |  ..||..|.
qeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyf

PNKGVI----KYGRFKVKMDSVTETAEYVIRSFQLSEDGKetgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHR-ANIVVHCSAGVGRTG
|..  .    .|| ...|.....|. .| .|.. |..  .   .||.. . .  |||| .|| ..... |.. |..  .. |.. | .|||||||.||||
Pdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

TYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
 .| |.  .  ...|. ||. . . ..|..|  .||.  || .|| || 
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
0049772 (Phosphotyrosine protein) phosphatases II 6-249 7.5e-48 159.2 In-house 38-279 (314) alignment 
Range on Protein: 6-249
Range on HMM: 38-279/314.0
MNHSNLPPNKDKNRYINIIAYDhTRVKLkPTDGIEGSDYINASYVNGYqspDKFIAAQGPKDNTLEDF----------WRMI--WEYNCSTIVM------
.  ..|..|.|||||..|. .| .||.| |. ...||||||||||.|.    ||||.|||...|..||          |||.  ...|. .|||      
ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LTKCIEDGkdkcsqywPNKGVIKYGRFKvkmdsvteT----AEYVirsfqlsedgketgQRSITQFHFLGWPDHGQPdYPSPMMC
               |... . |        .   .  .  .|        .    .|..              .| . ... . .||...|  .. .  
adelsrLdaAlgKtpllildgng........neptaadlellk........eelydpelf..............erlgikylripvpDgsap.lledfde

LIKRVRHLtskmNHRANIVVHCSAGVGRTGTYIVIDAMLDMMkhekQVDIYNFIHDIRQQRN-----TLVQSFVQYFFIHMALLEE
... .. .    .   ...|||.||.|||||..|.. ..  .    .|..   ..|.|..|       ..... || ||..|||| 
flefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 7-247 9.5e-89 292.2 In-house 40-276 (288) alignment 
Range on Protein: 7-247
Range on HMM: 40-276/288.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK
. ..|. |..|||| ||..||..|||||  .  .|.|||||||..|...  |.||.|||  .|..|||....|.. |||||||. .|.|| || .|||..
tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda

GV-IKYGRFKVKMDSVTETAEYVIRSFQLSedgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHlTSKMNhRANIVVHCSAGVGRTGTYIVIDA
.   .|| ..|.. .. |. ..| |.. |    |..... |||...|.||||| |.   |.. |.. |   ... .   .|.||||||||||||.|..||
dkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkv.anqad.tgpiivhCsaGvGrtgtFialda

MLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
..|....|...|. .... .|.||..|||   || ||. .||
lidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
0042113 (Phosphotyrosine protein) phosphatases II 7-248 1.9e-85 281.4 In-house 2-241 (245) alignment 
Range on Protein: 7-248
Range on HMM: 2-241/245.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK
....|| ||||||| .|..||||||||.|..| ..|||||||||.||. ..||||.||| ..|.||||||.||....||||||.. |.|. || ||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmNHRANIVVHCSAGVGRTGTYIVIDAM
....||.|.|.. |..  ..|..| .... . ..  .| ....|.|.||||| ||... .  ....||.  .. .    ..||||||||||||.|... |
esltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylm

LDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|.....|. |.... ....|.||   ||.. || |...||||
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 7-248 1.5e-70 232.4 In-house 39-281 (290) alignment 
Range on Protein: 7-248
Range on HMM: 39-281/290.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEG--SDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP
.. . . || .||. ||. ||  |. |.|  | .    .||||.|..||.   ..||.|||  ||| |||..||. ... |||||. ||.||.|| ||||
tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWp

NKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhRANIVVHCSAGVGRTGTYIVID
.... .|| |..|. . ... ||..| ... .. ..  ..|.||...  |...|.   |. .. .|... .   |   .  ||||||..|||........
dsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHCSdtvgrsavfcaaa

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
  .. .| | ..|... ..  |.|.  .||. .|| .|.  .|.
ttinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
subfamily_PTPN1_pd Subfamily PTPN1 7-256 7e-63 207.0 In-house 25-277 (290) alignment 
Range on Protein: 7-256
Range on HMM: 25-277/290.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGiegsDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK
....|| |...||| ..  |||.|.||. .|     |||||| |.  .   ..| .|||  || . ||.|.|| .. ..||| |..| .. || ||||..
reaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

G---VIKYG--RFKVKMDSVTETAEYVIRSFQLsEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYI
     ...   ..|||. |  .. .|..| ..| |. |    |.|..||.. ||| | |. |. .. .. .||.  |  ..    |.|||||.||.||..
eeekellledtklkvkliseerksyytvrllel.enlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfc

VIDAMLDMMKHEKQ---VDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSD
..|..|  ......   ||| . . ..|..|  |.|   |  | ..|.||   . ..|
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgd
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 7-248 1.4e-40 133.7 In-house 30-267 (281) alignment 
Range on Protein: 7-248
Range on HMM: 30-267/281.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKP-TDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN
   | | |. ||||.|| . | .||.||      . .||| | |.        .| .|||| .|  |||||||. | ..|||| . .|  ..||..|.| 
tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr

K--GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKeTgqRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltskmnHRANIVVHCSAGVGRTGTYIVI
.   .... .. |. .  |     |   ..|| .|. |  | ||.. .  |||   |.    |. .....|       . .  |.||||||||.|| . .
nahcclqfdklsvsyedstvnkslvttrlnlsyege.t..rlithwlwkewpdwqvpessevmlkilrkira......rstppvihcsagvgrsgtlmav

DAMLD-MMKHEKQVDIYNFIHDIRQ-QRNTLVQSFVQYFFIHMALLE
.  |. .  |    || . .  .|   | . ||.. ||..|   ||.
eialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_egg_pd Subfamily egg 7-277 4.9e-31 102.5 In-house 33-299 (307) alignment 
Range on Protein: 7-277
Range on HMM: 33-299/307.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDgkDKCSQYWPNK
...    |..| |   .   | .||||.   |    |.| | .|.|    ..|| || |  || .|||||... ..  |||||   |   ..|  |||. 
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

--GVIK--YGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHflgWPDHGQPDYPSPMMCLiKRVRhltskmNHRANIVVHCSAGVGRTGTYIV
    ..   | ....   | ..|. . |  .|   | .  .| .  .    .  .   |  ||.  | ...|      |    .||..  || ...| . 
esdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq...gdvnnssdvysplrvl.rklr......nlskpvvvqdilGvskaatlva

ID-AMLDMMKH-EKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL--EEHLFGHSDVAMPDFPAYYQQLSNKSDFDD
|. |.|....    .  . . .  .|..|.  |.| ..|.|..  .|     . | .     |.  . .. |.|  .||
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdyerwleersekmfldd
subfamily_PTPN12_pd Subfamily PTPN12 8-248 2.7e-76 251.2 In-house 34-275 (290) alignment 
Range on Protein: 8-248
Range on HMM: 34-275/290.0
HSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG
... . |. |||| .|. ||..||.|. ... ||||||||....| ... ..||||||  .||.||||||||.| . .||. . .| || || .|||..|
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

--VIKYGRFKVKMDSVTETA-EYVIRSFQLSEDgkeTGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmNHRANIVVHCSAGVGRTGTYIVID
   ...| |.|....   .  ...||....  .     .|...|||.  ||||| |  ..... ||. ||.| .  .. | .||||||||||||| |.||
eeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaid

AMLDMMKHEKQ---VDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
 . ...|.||    .|... . ..|.||..|||.  || ....|..|
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 8-274 9.4e-73 239.8 In-house 38-301 (315) alignment 
Range on Protein: 8-274
Range on HMM: 38-301/315.0
HSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN--
 .  . |  |||| ||. .|..||||.  | .  ||||||||......   .||.|||.. ...|||||..... .||||.||  |. | || ||||.  
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrk

KGVIKYGRFKVKMDSVTETAEYVIRSFqLSEDGKEtgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLtsKMNHRANIVVHCSAGVGRTGTYIVIDA
   ...| .||.. |.  ... |.| .    ...|  .| .|||.| .|||.| .   | .. ||| |.    . ..  ...|||||||||||  | || 
adsvefGsikvellsleadtdgvarkl.vtrksee..srtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvviside

MLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSD
... .|... ||..||.. .|..|  |||.  .| ||. |.||. |.  . . .  |  . |.|   .|
vvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 8-55 1.8e-12 41.3 In-house 41-88 (440) alignment 
Range on Protein: 8-55
Range on HMM: 41-88/440.0
HSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQS
 ..|| || |||| ||.||||.|| |.   |.  ||||||||.|| .|
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 9-249 1.5e-88 292.0 In-house 51-289 (298) alignment 
Range on Protein: 9-249
Range on HMM: 51-289/298.0
SNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGV
.. | ||.|||| .|||.|..|| |. .|. | |||||||....|.  . |||.|.|  .|.||||||..|.. .||||||.  | .| |...|||..| 
arkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk

IKYGRFKVKMDSVTETAEYVIRSFQLSEDGKEtGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHlTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLD
 .||...|.. |  | |....| ...|.  .| ..|.. |.||  |||.| | . . .. |...||  . . .  . ..|.|||||||.||.|.||..|.
etygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvle

MMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
 .|.|. ||... .. .|..| ..||.  || ||..| || 
rvkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 9-248 1e-83 275.7 In-house 36-274 (281) alignment 
Range on Protein: 9-248
Range on HMM: 36-274/281.0
SNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG-
|. . |. ||||.||.|||.||||..|..  . .|||||..|.||... ..||.|||  ..|..||.|.||.. |.|||.|. || || || .|||..  
skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns

VIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKEtgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHrANIVVHCSAGVGRTGTYIVIDAML
 .||| ..||. . .|.|.|. | |.|.... |  .|...|.... ||||| |. .. ..   | |..||.| .. | .|.||||||||||||| .| ..
elkygdvtvkstaeeekatyierkfkleresge..treveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtGtyialDrlv

DMMKHE-KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
. ...| ...|. . ....|..|| .||. ||| |.. |.|.
kaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_PTPN6_pd Subfamily PTPN6 9-246 2.8e-79 261.3 In-house 49-293 (306) alignment 
Range on Protein: 9-246
Range on HMM: 49-293/306.0
SNLPPNKDKNRYINIIAYDHTRVKLKpTDGIEGSDYINASYVNGY--QSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK
.. | || |||| ||. .|||||.||  ... |||||||.|...   .|  ..||.||  ..|..|||||.|. |.  |||.|| .| ||.||..|||..
gakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde

GVI-KYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMN--HRANIVVHCSAGVGRTGTYIVI
    .||. .|.. | ...|.|..|....|.  |.. .|.. |.||  ||||| |  |. .. ... |.. .....  .   ||||||||.|||||.|||
eekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfivi

DAMLDMMKHE---KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMAL
|..|......    ..||..... .|.||. |||   || |...|.
Dillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 9-279 1.3e-74 246.3 In-house 43-317 (325) alignment 
Range on Protein: 9-279
Range on HMM: 43-317/325.0
SNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMlTKCIEDGKDKCSQYWPNK--
. .| ||.|||. |..|.|..|| |.  .    ||||||||.. ..  | |.||| |. .|..|.||.. ...|| .|. .  .. |||.|..|||..  
amkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavywpkemg

GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNH----RANIVVHCSAGVGRTGTYIV
   ..| ..||. .. | ..|| | ... .  |.   ||. ||.. .|.| |.. .|. .. ... | ..  ...      . |.|||||||||||..| 
ksktfGglevklrtieeisdyvhrvldvkqv.kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

IDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDDL
. ..|. . .| .|||..|.. .|..| ..|..  || .|. || |  . | .|| .  | |    | ..  . . |
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqkl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 9-287 2e-58 192.7 In-house 40-272 (392) alignment 
Range on Protein: 9-287
Range on HMM: 40-272/392.0
SNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGkdkcsqywpnkgv
.. . |. |||| ||. || .||||.  | |  |||.||||......   .||.|||.  .|.|||||... | .||.|.||  |               
aqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.............

ikygrfkvkmdsvtetaeyvirsfqlsedgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHraNIVVHCSAGVGRTGTYIVIDAMLD
                              |   .|...||||  |||.. | . | .. .|| |.    .  |   ...||||||||||  | ||... 
..............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth..pliihcsagvgrtgvvisidsvva

MMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDdLTKLEVEFR
  |. . ||..||. .||..|  .||.  || ||. |.||. |.  . . .  |  . |.||  || |   .|   |||
hakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdv.rskqlkefr
subfamily_PTPRN_pd Subfamily PTPRN 10-249 1.2e-59 196.5 In-house 52-291 (297) alignment 
Range on Protein: 10-249
Range on HMM: 52-291/297.0
NLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQS-PDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGV
. . | .|||. ....|||.||||| .   | ||||||| .   .     .||.|||  .|. |||.|.||  .  ||.||.  |.|  .|..|||..| 
kaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGs

IKYGRFKVKMDSVT-ETAEYVIRSFQLSEdGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltSKMNHRANIVVHCSAGVGRTGTYIVIDAML
  |. ..|.. |    . .|..||| | .  . .  |..|||||| ||..| |  . ... . ..|    |     . ||||||.|.||||.||.|| .|
evyhiyevhlvsehiwcddylvrsfylkn.lqtsetrtvtqfhflswpeegvPasaksllefrrkvnk..syrGrscpivvhcsdGaGrtGvyilidlvl

D-MMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
. ..|  |..||   .  .|.||. ||..  |. |. .|. ||
nrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 10-252 8e-49 161.3 In-house 37-279 (307) alignment 
Range on Protein: 10-252
Range on HMM: 37-279/307.0
NLPPNKDKNRYINIIAYDHTRVKLKpTDGIeGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVI
 .  | ||||| .. . |..|. .| .||.  |||| | |.     | |||.||||..||  .|| |. . .  ...|| |.|| .| || |||| .   
afsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

K--YGRF--KVKMD--SVT--ETAEYVIRSFQLSEDGkETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltskmnHRANIVVHCSAGVGRTGTYI
|  .|     . ..   .      | .|   .|  |    . |.|... .  |||.| |.     . |.. ||       ..  .||||||||||.|| .
klvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltainlleavry......dtnpvvvhcsaGvGrsGtiv

VIDAMLD-MMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLF
 |  . | |.. .   |. ......|.||.  .|. .||...|  |||  | 
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 10-107 1e-11 38.0 In-house 23-88 (169) alignment 
Range on Protein: 10-107
Range on HMM: 23-88/169.0
NLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINAsyvngyqspdkfiaaqgpkdntledfwRMIWEYNCSTIVMLTkcieDGKDKcSQYWPNKG
.|  |. |||    .|  ||||||.      |||||||                           ||||| | | ||.|     |  ||  ..||.| 
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlg....dtddk.nnfwpeke
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 10-107 1.5e-11 37.4 In-house 22-87 (169) alignment 
Range on Protein: 10-107
Range on HMM: 22-87/169.0
NLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINAsyvngyqspdkfiaaqgpkdntledfwRMIWEYNCSTIVMLTkcieDGKDKcSQYWPNKG
.|  |. |||    .|  ||||||.      |||||||                           ||||| | | ||.|     |  ||  ..||.| 
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlG....dtddk.nnfwpeke
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 11-249 2e-82 271.2 In-house 6-241 (250) alignment 
Range on Protein: 11-249
Range on HMM: 6-241/250.0
LPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDkCSQYWPNKGVIK
 | ||.|||| .|||.|..|| |....| . |||||||...||.  . |||.|||  .|.||||||..|.. .||||||.  | .|  ..|||| ..  |
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

YGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhRANIVVHCSAGVGRTGTYIVIDAMLDMM
||  .|.. |  | |.|..| ..||.  |....| . |.||. ||| | |..   .. |.|.|.    . .  | ..|.|||||||.|..|.|||.|. .
yGdvtvsllskeefadytkrklklska.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqag.naPvivqCsaGvgrsGafiaidavlerl

KHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
|.||.||....|. .|..|   |.|  || |.....|. 
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 11-248 2.6e-68 225.1 In-house 44-276 (287) alignment 
Range on Protein: 11-248
Range on HMM: 44-276/287.0
LPPNKDKNRYINIIAYDHTRVKLKptdgIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIK
 . ||||||. .|. .|  || ||     |  |||||....||..  .||.|..|  ||. .||..|.. | ..||||..  |. ...| ||||..  . 
asqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvv

YGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHlTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMM
.| ..... . . .|.|..| ... ...|.. .....|...  |...|.   |  .. .|..  . | . . .. ||||||..|||..... ..  ..  
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk.tqrkrgntsivvhCsdtvGrsamfcaaattinkc

KHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
| |  .|... ..  |.|. . ||   || ||  ..||
kteGviDvfqvlksqriqkpgsvqtveqykfindivle
subfamily_PTPN13_pd Subfamily PTPN13 11-248 4.8e-67 221.1 In-house 34-267 (273) alignment 
Range on Protein: 11-248
Range on HMM: 34-267/273.0
LPPNKDKNRYINIIAYDHTRVKLKPTDGiegsdYINASYVNGYQSPDKF--IAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN---
   ||||||| |.. ||.|||||.   |     |||||...     |..  ||.|||  .| .|||.|.|| ... |.|.|.  |.|| || .|||.   
kkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPeskn

KGVIKYGRFKVKMDSVTETAEYVIRSFQLSeDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmnHRANIVVHCSAGVGRTGTYIVIDA
| .  ..|..|..  |..  ..|.|..... | . .  | .....|  ||||| |  . ... ....||.| .   ... ||||||||.||.||.|.||.
kklkvsnrlevellkvqkldgfvvralavk.dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrsGtlitidv

MLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.|......|..|. . ....|.||...||.  || |.. |.||
vlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 11-244 5e-36 119.0 In-house 47-275 (301) alignment 
Range on Protein: 11-244
Range on HMM: 47-275/301.0
LPPNKDKNRYINIIAYDHTRVKLKpTDGIEgsDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GV
   .|||.|| ..    .| |..  .||      | | ...    |..|||.||| .|| |||| |.  |.  .||||.. .|. ..||..| | |    
aylpkdkhryptvPckPstavevi.vdGkr..vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

IKYGRFKVKMDSVTETA--EYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltskmnHRANIVVHCSAGVGRTGTYIVIDAM
.. ||||.|. .       . . |.... .  ..   |..| . .  |.|.| |     .. |.. |..       .  ||||||||.||. ..|  . .
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk......sekPivvhcsaGiGrsvafigteyl

LDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHM
   .. ...... . ....|..| . ||   | ... .
areveadptieltealkhlrehrwngvqtnsqlywmtl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 11-263 6e-20 66.1 In-house 44-293 (303) alignment 
Range on Protein: 11-263
Range on HMM: 44-293/303.0
LPPNKDKNRYINIIAYDHTRVKLkpTDgiegSDYINASYVNgYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVML-TKCIEDGKDKCSQYWPNKGVI
.  | ||||....|  ||..|||  .|    | || |||..  .|  | | .| |   |  |||.|| | .   ...| | .  |     | .  |.  .
fvknmdknrfvdvicldhskvkl..sd....ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

KYGRFKVKMD---SVTETAEYVIRSFQLSEDgkeTGQRSITQFHFLGWPDHGQPDYPSPMM-CLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVID-
|.    ...     |  .  .|..   .|.    . .  .   |.  ||    |   || .   | ... .  |  .    |    .|.||.||. ... 
kfeersirvgefkrvelgdgwvlkvlsvsng...dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfet

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHmALLEEHLFGHS--DVAMPDFP
| | . . .  .|. . .  .|. |   || . |. ... .|| ||...     .|.|  |
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvy.tllaehvldngicklaipkkp
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 11-54 6.7e-09 29.7 In-house 36-78 (244) alignment 
Range on Protein: 11-54
Range on HMM: 36-78/244.0
LPPNKDKNRYINIIAYDHTRVKLKPTdGIEGSDYINASYVNGYQ
|  |  |||||||. .|.||| |  .   ||||||||.|..| |
lsanatknryinilpfdetrvilsss.kkegsdyinanyiqgsq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 12-250 4.7e-37 122.5 In-house 33-270 (285) alignment 
Range on Protein: 12-250
Range on HMM: 33-270/285.0
PPNKDKNRYINIIAYDHTRVKLKPTDgiegSDYINASYVNGY-QSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GV
  | | ||| .. . . ||| ||  |     ||| ||..    .    .|..|||  .|| |||.||.. . . ..||   .| | .||. |.|.|   |
eanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

IKYGRFKVKMDSVTETA--EYVIRSFQLSEDGKETGQ-RSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmnhRANIVVHCSAGVGRTGTYIVIDA
.|.|.... .  . | |    .. .. . .    . .   . . .   |||.  |.   ||. | | |...  |      |.|||||||||| |.. || 
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk...ekpicvhcsagvgrtatfvgidy

MLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEH
    .  . .... . ....|  |   |||..|..|... |.|  
atirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 13-269 5e-82 270.3 In-house 48-298 (315) alignment 
Range on Protein: 13-269
Range on HMM: 48-298/315.0
PNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIkYG
 ||.|||||||||||..||.|  ..  ..|||.||....||. ....||||||. ....||||...|.....|||||. .|. | |. .|||.| || ||
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkvi.yG

RFKVKMDSVTETAEYVIRSFqlSEDGKEtGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLtsKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKH
.. | . |     || .|..  |   ..   | . |.|.  ||| | | |  |.| ||..|.    . |  . ||||||||||||||.| .||.|| .. 
kitvtrkseevnteytvrtl..svvfgd.nirevvqlhytswpdmgvpkytiplmnlirtvkqh..htnsvgaivvhcsaGvGrtGtfitldavldqaea

EKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQL
|. .|.||||. .||.|  .||.  || ||. ||||  . | . .|   .   |. |
enaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 13-261 1.7e-61 202.6 In-house 32-277 (283) alignment 
Range on Protein: 13-261
Range on HMM: 32-277/283.0
PNKDKNRYINIIAYDHTRVKLKPTDGiegsDYINASYVN---GYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVI
 || |||. .|...|  ||.||.       |||||...     |.   |.|.||.| |.|  |||.|... . ..||||||  || . |||||||..| .
enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse

KYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQpDYPSPMMCLIKRVRHLTSKmNHRANIVVHCSAGVGRTGTYIVIDAMLDM
.|| | | .   |    ..|. . |  ..    .  .. . . .| . |. . .   .  . .|. |  . .... ||||||.|.|||...| . | .. 
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyge.qaiinslvkfnkvislqte.skkgPivvhCstgiGrtavfiaasasvkd

MKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPD
.. |  ||... .. .|.|| ..||.  || ..| . ||. | | ...|. |
altesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavd
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 13-248 1.5e-49 163.4 In-house 32-257 (267) alignment 
Range on Protein: 13-248
Range on HMM: 32-257/267.0
PNKDKNRYINIIAYDHTRVKLKPTDgiegSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCiedGKDKCSQYWPNK--GVIK
 |...||. . . ||.||| |. ..     .|||||||.||.   .||. |.| .||  ||. .| ......||.|||    ..|.  ..|| |     |
knqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakk

YGRFKVKMDSVTETAEYVIRSFQLSedGKETGQRSITQFHFLGWPDH-GQPDYPSPMMCLIKRVRhLtskMNHRANIVVHCSAGVGRTGTYIVIDAMLDM
|  . |.     |  .| | ...|    |.   . .| ...  |     .  |  |.. .. . . |    |    .||.||.||||.||..|||..|. 
yqdltvehslekeendyqiitlelk..fknesahnvtlyyykkwnintnnkpylkplfgilaknq.l...engnrPlvvacsdGvGrsGtflvidsqler

MKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.|.|  .||..|.  ||.|| .||..  .| .||  | |
aktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 13-248 7e-49 161.3 In-house 32-293 (297) alignment 
Range on Protein: 13-248
Range on HMM: 32-293/297.0
PNKDKNRYINIIAYDHTRVKLKptDGIEGSDYINASYVNGYQ--SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN--KGV
    |||| .|.|.| |||||.   .| ..||||| ||   .  .. |.| |||| ..|..|||....| .  .|||..|  |||.|||  |||.  .. 
sslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

IKYGRFKVKMDSVTET--AEYVIRSFQLSEDgkeTGQRSITQFHFLGWPDHGQP----D---Y---------PSPM-MCLIK--------RVRHLTSKMN
 | | . |.  | |       ..  .||      . .| ..   ||.||||| |    |   .           || ..|..        ..  | ..| 
lkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemp

HRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
  | ..|||||||||.|  .  |..|.......  |.  ... .|.||  |||.. |. ... | |.
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 13-248 2.9e-46 152.4 In-house 53-281 (290) alignment 
Range on Protein: 13-248
Range on HMM: 53-281/290.0
PNK--DKNRYINIIAYDHTRVKLKptDGIEGsDYINASYVNGYQSPdkFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GV
 |    |||| ...  | ||| ||  || .| ||. | ||.| ...  || .||.  .|  |.|||. . . ..|||| . ||||| ||.||.|.|   |
kntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

IKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDypsPMMCLIKRVRHLtskMNHRANIVVHCSAGVGRTGTYIVIDAMLD
. .| . |     ..  . .|.      | ..  .  .  ..   |||.  .      . |.. .| |    .    .|||||||.|||||.. |.. |.
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksval...stlallrtlril...rkasGpvvvhcsaGiGrtGtfvaievglq

MMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.. . |..|. . .  .|. | . ||  .||. .  .||.
illdGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_CG42327_pd Subfamily CG42327 13-175 1.1e-30 101.4 In-house 27-192 (319) alignment 
Range on Protein: 13-175
Range on HMM: 27-192/319.0
PNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQ-SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG----
  |||.|.||..   .||| |.     . . |..|||| ||. .|  .|||| . ...  ||||..|| .  .|| ||.  | | ..|..|.| |     
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

VIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETgQRSITQFHFlGWPDHGQPDYPSPMMCLIKRVRH
   || ..| .       .|.| .. | .  ||   | .| . .  |.. . |  ........ .|| 
tslyGdilvtlkgrevkdryaistlllkrvdkee.srelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 13-98 3.6e-13 43.7 In-house 33-117 (332) alignment 
Range on Protein: 13-98
Range on HMM: 33-117/332.0
PNKDKNRYINIIAYDHTRVKLKPTDGIEgsDYINASYVNGYQSPDKFIAAQGPK-DNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDK
 | | ||   . ..||.||.| | || .  |. |||.|.||     .| || |  | |   ||||. | . | |...    |  | |
nnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_PTPRK_pd Subfamily PTPRK 14-286 7e-89 292.8 In-house 43-312 (314) alignment 
Range on Protein: 14-286
Range on HMM: 43-312/314.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIkYGR
|..|||. .|.|||..||.|...||   ||||||.....|. | .||..|||...|..||||.....||..|||||. .| |. ||..|||... . || 
nreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygd

FKVKMDSVTETAEYVIRSFQLSE-DGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmnHRANIVVHCSAGVGRTGTYIVIDAMLDMMKH
.||.. ...  ||.|.| |....   .  ..| . ||.|||||||. | .   .. |..|| . . .  .  .|||||||| |||||.|.|| .|||...
ikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmier

EKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLsNKSDFDDDLTKLEVEF
|. ||..| ....|...  .|.   || ||. ..||  | |.. . . .| | | .  .. | . . ..|. ||
egvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyles.irldpqtnssqlkeef
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 14-262 2.7e-88 291.1 In-house 46-295 (305) alignment 
Range on Protein: 14-262
Range on HMM: 46-295/305.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVI--KY
|| |||. .|. .|. |..|....  . |||||||||.||.. .|.|.|||| .||..||||.|.|.  |||||||| .|.||||| ||||..     ..
nkaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkef

GRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmNHRANIVVHCSAGVGRTGTYIVIDAMLDMMK
|.|.|.. | .....|..| ...| . ..  .|...|...  ||||| |.... .. |||||..  .| ..   ..|||||||||||..|..| .|. .|
gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkgvpllVhCsagvgRtGvfiavdialerlk

HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDF
.|..||... .. .|..|  .||.  || |.| || |.   |. .. . ..
kEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl
Y_phosphatase Protein-tyrosine phosphatase 14-248 1e-86 285.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 14-248
Range on HMM: 1-235/235.0
NKDKNRYINIIAYDHTRVKLkpTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP--NKGVIKY
||.|||| .|..||.|||||  ..  . ||||||.||.||... ||||.||| ..|.||||||.|......|||||.. | |. ||.||||  ...  .|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GRFKVKMD-SVT-ETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTskMNHRANIVVHCSAGVGRTGTYIVIDAMLDM
|..||..  ... ...||..| ..|.....|. .|...|.|. .||||| |. |.... ||..|.. .   ......|||||||||||||....|..|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

MKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
...|..||.....  .|.||. .|||. || |...|.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 14-248 1e-86 285.5 In-house 1-235 (235) alignment 
Range on Protein: 14-248
Range on HMM: 1-235/235.0
NKDKNRYINIIAYDHTRVKLkpTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP--NKGVIKY
||.|||| .|..||.|||||  ..  . ||||||.||.||... ||||.||| ..|.||||||.|......|||||.. | |. ||.||||  ...  .|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GRFKVKMD-SVT-ETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTskMNHRANIVVHCSAGVGRTGTYIVIDAMLDM
|..||..  ... ...||..| ..|.....|. .|...|.|. .||||| |. |.... ||..|.. .   ......|||||||||||||....|..|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

MKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
...|..||.....  .|.||. .|||. || |...|.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 14-274 1e-74 246.5 In-house 43-300 (515) alignment 
Range on Protein: 14-274
Range on HMM: 43-300/515.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN--KGVIKY
|  |||| ||. || .||||.  .    |||.||||......   .||.|||.. ...||||.....| .||.|.||  |. | ||..|||.     .|.
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GRFKVKMDSVTETAEYVIRSFQLSEDGKetgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHraNIVVHCSAGVGRTGTYIVIDAMLDMMK
| .||.. |.   .. ..| ...  . .    | .||||| .|||.| |   | .. ||| |.  .....|   ...|||||||||| .| || ..  .|
Gsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyth..pliihcsaGvGrtGvvisidsvvahak

HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSD
  . ||..||.. |||.|  |||   || ||. |.||. |.  . . .  |  . |.|    |
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgd
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 14-248 3.8e-70 230.8 In-house 3-237 (237) alignment 
Range on Protein: 14-248
Range on HMM: 3-237/237.0
NKDKNRYINIIAYDHTRVKLKPTDGieGSDYINASYVNGYQ-SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG-VIKY
|| |||| ||.||||.|| || . .  |||||||.|..|.. .| |.|||||| ... .|||.|.|. .|| |||||  ||  . || .|||.      |
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMK
| . | .    | ..| .||. ||. ..  . | | |..|  |||.| |.. . .. . |.. . . .... .  ..|||||||||| ..||||||   |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
 .| |||||... | ..|  ..|.  || ||| ..||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 14-251 2.9e-68 225.2 In-house 51-285 (297) alignment 
Range on Protein: 14-251
Range on HMM: 51-285/297.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSpdKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKdKCSQYWPNKGVIKYGR
| .|.|| ||. ||  ||||. ..    |||.|||.|.|..   ..|. | |...|..|||.|..... ||||||..  |  | || .||..||| ..| 
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGd

FKVKMDSVTETAEYVIRSFQLSEdGKETGQRSITQFHFLGWPDHGQPD--YPSPMMCLIKRVRHLTSKMNHRaNIVVHCSAGVGRTGTYIVIDAMLDMMK
  |.. ||.|   .. |...... ||   .| . |..|. |||.  .     | .. ||. ||.  |. ..   ..|||.||||||| .. || ..  .|
vsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeak

HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
.||.|||..... .||.|  |||   || |.. |.||  |
rekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 14-248 8.8e-67 219.7 In-house 7-238 (239) alignment 
Range on Protein: 14-248
Range on HMM: 7-238/239.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQ-SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKgVIKYG
|| |||| ||..|||.|| |.       ||||||||.  |. ||  .||.||    .  |||||.|.     |||||  ||  | || ||||.    || 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

RFKVKMDSVTETAEYVIRSFQLSEDGKeTGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKH
 ..| .      |.|.||.| .|. |. | .| . |.||  |||.| |.| . .. | ... .    .      |.||||||||||...||||||   |.
nlrvtlrktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidamlrqakk

EKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.| |||.|... ||..|  .||.  || |||.|.||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 14-248 1.3e-66 219.2 In-house 8-239 (239) alignment 
Range on Protein: 14-248
Range on HMM: 8-239/239.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQ-SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKgVIKYG
|| |||| ||..|||.|| |.       ||||||||.  |. ||  .||.||    .  |||||.|.     |||||  ||  | || ||||.    || 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

RFKVKMDSVTETAEYVIRSFQLSEDGKeTGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKH
 ..| .      |.|.||.| .|. |. | .| . |.||  |||.| |.| . .. | ... .    .      |.||||||||||...||||||   |.
nlrvtlrktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidamlrqakk

EKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.| |||.|... ||..|  .||.  || |||.|.||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 14-247 2.7e-65 215.1 In-house 20-261 (270) alignment 
Range on Protein: 14-247
Range on HMM: 20-261/270.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQS-PDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK----GV
.|  ||| .|.   .|||.|.. .  . . |||| ||.|... . |.|||.||...||..||||||| . ..|||.|.  |.|..||..|||..      
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

IKYGRFKVKMDSVTETAEYVIRSFQLSEDGKEtgqRSITQFHFLGWPDHGQPDYPS------PMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIV
...|  ||   | . .  |...  .| |.|.|   | .. |..  ||||| |  .        .. ... ||. ......   ..|||||||||||| |.
ledgkikvlalseekeegyiltrlrleekgee...rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
.| .. .....|.||. . |...|..|  |||  .|| |.. |..
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_CG7180_pd Subfamily CG7180 14-251 4.1e-64 211.1 In-house 42-291 (296) alignment 
Range on Protein: 14-251
Range on HMM: 42-291/296.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKdKCSQYWPNKGVIKYGR
|..|||..... ||..|| |.  || | ||||||.||...  . ..|  ..||..|...|||.... ..|..|.|||  .  | .. .|||||.  .|| 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

FKVKMDSVTETAEYVIRSFQLSED---------GKETGQRSITQFHFLGWPD-HGQPDYPSPMMCLIKRVRHLTSKM---NHRANIVVHCSAGVGRTGTY
. |.. .. . |. .|| |.|            . .. .| ...|..  |.  .  |   . .. |..||| .  |.   .... .||..| |..|.| |
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

IVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
. ||| |.....|..||.....  .|..|. ||..  .| .|   |||  |
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPN23_pd Subfamily PTPN23 14-248 4.8e-58 191.3 In-house 43-278 (288) alignment 
Range on Protein: 14-248
Range on HMM: 43-278/288.0
NKDKNRYINIIAYDHTRVKLKptdgIEGSDYINASYVNGYQ--SPdKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GVI
. .|||. .|. |||.||||.     .  ||||||.|..    .| .|||.|.|...|| |||.|..|   |.||||..  | || |...|||..     
yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

KYGRFKVKMDSVTETAEYVIRSFQLSEDGKETgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRH--LTSKMNHRANIVVHCSAGVGRTGTYIVI-DAM
|.| ..| . ||.|| ..| | ..|.  ....  .|..  ..  ||..| |. |. .. ... |..   . . . .. .||||||||||||.. ..  |.
kfgdlsvtlksvretethvervlkletldada.vksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

LDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
 .. |..  .|| . .. .|.||   ||   |. |   | ||
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
0041856 (Phosphotyrosine protein) phosphatases II 14-254 6.1e-55 180.9 In-house 1-175 (182) alignment 
Range on Protein: 14-254
Range on HMM: 1-175/182.0
NKDKNRYINIIAYDHTRvklkptdgieGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTkciedgkdkCSQYWPnkgvikygr
|.||||| .|. |||.|          ..|||||... |.. ...|||.||| ..|..||.||..|....|||.||         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

fkvkmdsvtetaeyvirsfqlsedgkETGQRSITQFHFLGWPDHGQPDyPSPMMCLIKRVRHltskmnHRANIVVHCSAGVGRTGTYIVIDAMLDMmkhe
                          |  .| ..|...|.||||| || .. .  .|..|..      .  ...||||||||||||..... |. .    
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....

kQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGH
 .|.... .. .|..|.  |..  ||||...||||..|.. 
.gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 14-247 4.6e-54 178.1 In-house 38-274 (287) alignment 
Range on Protein: 14-247
Range on HMM: 38-274/287.0
NKDKNRYINIIAYDHTRVKLKpTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGV-IKYG
.  |||| ... .|.||| |  ..|  ||||||| || .|.  ..|||||||   |. ||||...| . ......|. .|... || .|||.. | .. |
avkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

RFKVK-MDSVTETAEYVIRSFQLSEDgkETG-QRSITQFHFLGWPDHGQPDYPSPMMCLIKRV-RH--LTSKMNHRANIVVHCSAGVGRTGTYIVIDAML
 . |  .|      || .|...| .   ||   | . |...| |||.. .     .. ..  | .|  |. . .    .|||...|.||.|... . ...
GysvvlldydikePeygvralrlidl..etrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

DMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
....   .||. . .  .|..|..|||. ||. ..  || 
srledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 14-246 2.4e-53 175.8 In-house 40-289 (301) alignment 
Range on Protein: 14-246
Range on HMM: 40-289/301.0
NKDKNRYINIIAYDHTRVKLKPTDG--IEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG--VI
||  ||. ||  ||. |. |||.    .   .||||||..||..  |||||||| ..|| ||||.||..  ..|||.|.  |. |.|| |||||      
nkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaese

KYGRFKVKMDSVTETAEYVIRSFQLS-EDGKE-------------TGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhRANIVVHCSAGVG
..| |.|.. . .   ..|||....  .|| .                ....|..   ||..|    |  ..  |  | | . |..  . .|||||..|.
efgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkig.ggpvvVHCSdtVs

RTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMAL
|.|.|. ..  |.  | |  ||... .. .|...   |.   || .|. ..
rsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi
subfamily_ptpA1_pd Subfamily ptpA1 14-217 1.7e-45 150.5 In-house 47-264 (418) alignment 
Range on Protein: 14-217
Range on HMM: 47-264/418.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYqSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK-------
|  |||| ||.  .||||.||  .  |||||||| |..|   | .||..|||  ||. |||||.||  |  ||||..  |. . || .|||..       
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

----GVIKYGRFKVKMDSVTETAE--YVIRSFQLSEDGKetgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRV----RHLTSKMNHRANIVVHCSAGVGR
    |   .| . |..  | .  |   . |  .|. .|.    | |||... |||||  ||.  |.  |.. .     ..    ..   |.|||||||||
iygngnevfgtysvelveviqdpereiitrnirltfege...trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGTYIVIDAMLDMMKHE-KQVD
|||.     |.  . |  ||.|
tgtfctavimmkkldhyfkqld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 14-251 1.1e-41 137.5 In-house 55-290 (305) alignment 
Range on Protein: 14-251
Range on HMM: 55-290/305.0
NKDKNRYINIIAYDHTRVKLKPTDgieGSDYINASYVNGYQSPDK-FIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN----KGV
.. |||| .. . |.. |||.       |||| | ||     |.| ||.|||| |.|...|| |. . .   |||| | .| || ||.||||     |  
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

IKYGRFKVKM---DSVTETAEYVIRSFQLSEDGKETgqRSITQFHFLGWPDHGQPDypspmmCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDA
.| |    ..     .   ||  |  ..|.  |...   |. ....  ||| | |       | .  .  |..    .  ||||||||.||||| . |. 
lksgivvenvsgskpmerdaeiqitllnltysgdqk..msvrhlqwtewpdrgvpp......ckltslellsairgskvpivvhcsagigrtgtivaiey

MLDMMKHEKQVD-IYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
.|. .  .|..  . .... .|.||   .|. |||.|||  .|.  |
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 14-248 4.1e-41 135.7 In-house 48-285 (305) alignment 
Range on Protein: 14-248
Range on HMM: 48-285/305.0
NKDKNRYINIIAYDHTRVKLKPTdgiEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GVIKY
...|||| ..   |. ||||...      .|| | ||     | .|| .| | ..|  ||| | .. .  .| || . .| |  ||..|.. |   |...
eagknrykdvgcldnnrvklegp...wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

G----RFKVKMDSV-----TETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLtskmnhRANIVVHCSAGVGRTGTYIV
     .  ||..|      .. |. ...  .|  .|  . .| .|..|.  ||| | |     .. |... | .      .  ||||||||.||||. ..
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps......kgpivvhcsagigrtgsvvm

IDAMLDMMKHEKQVDI-YNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.. .|| .   ....     .  ||.|||  .|.  ||.|.|  .|.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 14-247 1.2e-36 120.9 In-house 52-287 (310) alignment 
Range on Protein: 14-247
Range on HMM: 52-287/310.0
NKDKNRYINIIAYDHTRVKLKpTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIK-YG
.  |||| ...  | .|||||  |     ||| | ||.     . || .||| . |. ||||||..  . .|..| |  |.|. ||  |||  || . ||
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

RFKVK-MDSVTETA-------EYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYpspmMCLIKRVRhLTSKMNHrANIVVHCSAGVGRTGTYIVID
  .|  .   .|          .|     . |.  .  .  ..  ..  ||| | ||      |     | | ... |    |||||||..|... . ..
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde....kchtvpqr.llaqvrh.gpcvvhcsagkdrlyvvvalk

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
  .| ... ..||. . . .....|   .|. .|| .|..  .
lkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 14-247 1.6e-24 80.9 In-house 51-282 (302) alignment 
Range on Protein: 14-247
Range on HMM: 51-282/302.0
NKDKNRYINIIAYDHTRVKLKptdgIEGSDYINASYVNGYQSPDKFIAAQGPKDNTL---EDFWRMIWEYNCSTIVMLTKCIEDGKdKCSQYWP--NKGV
| .||.  .. ..|...|||.     |  .|.||| |.  .   . | || || ..    |.||||... .. ..|.| .  |  |   |...|      
nlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

IKYGRFKVKMDSVTETAEYViRSFQL---SEDGKETGQRSITQFHFlgWPDHGQPDYpspMMCLIKRVRHL-TSKMNHRANIVVHCSAGVGRTGTYIVID
 .||.. |    | .. | .   . .    |.  ..   ... ...  |...  |.    .  ||| . .. ..|..  .|.|.    |.|| |. ..  
keygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltn..Wkqkkvpvk...yaeliktaakvfakkikadentvivSknGaGRagafltla

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
. .. ....|.. | . .. ||.|| . |.|. || ....|||
vaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 14-64 8.6e-11 35.9 In-house 48-95 (95) alignment 
Range on Protein: 14-64
Range on HMM: 48-95/95.0
NKDKNRYINIIAYDHTRVKLKPTdgiEGSDYINASYVNGYQSPDKFIAAQG
|  |||..||. || ||| |        |||||| .|.||   . .|||||
nipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 14-94 1.2e-08 28.9 In-house 37-122 (347) alignment 
Range on Protein: 14-94
Range on HMM: 37-122/347.0
NKDKNRYINIIAYDHTRVKLKPTDGIEG-----SDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIED
. .|||  .    | ||| | | .   .       |||||...  ..  ..| .| |  .|. |||.|.   . . .| . . |.|
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 15-262 7.2e-67 220.7 In-house 49-291 (439) alignment 
Range on Protein: 15-262
Range on HMM: 49-291/439.0
KDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKdkcsqYWPNKGVIKYGRF
. |||| .. |.||||| |. . |.  | |||| |..||  .. .||.||||..| .||||...| ...||||||. .|  |     ||| .. . ||  
qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdi

KVKMDSVTETAEYVIRSFQLSEDG-KETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKHE
 |..|   |  .|||| |.. ..  .   .|.. |||.. |||.  |   | .. ... .     | .    .||||||||||||| | .|  |. .| |
avrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdialeqlkle

KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDF
..|||   .. .|.||. .||...|| ||. |.||.  .|   |.. .|
nkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 15-252 6e-39 128.8 In-house 44-273 (288) alignment 
Range on Protein: 15-252
Range on HMM: 44-273/288.0
KDKNRYINIIAYDHTRVKLKptdgIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG--VIKYG
  ..|| |.   | |||||.     .   ||.|  |   . . ..| || | . |.| .|.|. | .   ||||.. .| ||.|  .|.| |    ...|
ptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarig

RFKVKMDSVTETAEYVIRSFQLsEDGKETGQRS-ITQFHFLGWPDHGQPDYPSPMMCLIKRVrhltskMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMK
|.   .    .  . ...   |    ||. ..  . . |.| |.|.| |.   . . |....       ...  ||||.||||||||| |.|  .|....
rlctvvkkkradidklvkvsll.riskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslr

HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLF
 . .. | ....  |..|   .|.  || ..|  .||| |.
lddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 15-248 4.2e-35 116.0 In-house 44-274 (312) alignment 
Range on Protein: 15-248
Range on HMM: 44-274/312.0
KDKNRYINIIAYDHTRVKLKPTDgiegSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN-KGVIKYGR
|| ||| ||  .|  |  |   .      || | .|.    |..|...||| .||   ||..     ...|..|.  .||| .||..|  .  | ..   
kdlnrypniqcwdrgrftlagde....nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

FKVKMDSVTET-----AEYVIRSFQLSEDGKETGQRS-ITQFHFLGWPDHGQPDYPSPMMCLIKRVRhltskmNHRANIVVHCSAGVGRTGTYIVIDAML
 .|  ...||      .   |    |    | ||| | . .. .  ||||| ||     . |.  |.      . .  .. ||||||||||| ..|..|.
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk......kdkkpviahcsagvgrtgtlaliesmi

DMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
  ..| .. .. .    .|..|   |. | || .   ..||
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 16-137 4.3e-26 86.5 In-house 49-185 (350) alignment 
Range on Protein: 16-137
Range on HMM: 49-185/350.0
DKNRYINIIAYDHTRVKLK----PTDGI----EGSDYINASYVNGY-----QSPD-KFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQ
 |||| ||. |.|.|||||    ..|..    ...|||||.|..       . || |.||.|.|  .|..||...| . .   |..||. .| . .|| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPNKGVIK-YGRFKVKMDSVTETAEYVIRSFQLSED
||.. .. .   ... | ...... . ...|... ..
YWqegsydditvklaskwenimgindsslysadvkke
subfamily_eak_pd Subfamily eak 16-249 2.6e-23 77.0 In-house 54-304 (332) alignment 
Range on Protein: 16-249
Range on HMM: 54-304/332.0
DKNrYINIIAYDHTRVKLKPTDgIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG--VIKYGR
..|  ..|. ||.  |.| ..   .   ||||| ..  .   |.| .  .... .  ||.|. | .  .||.| . .| . .|  .|.|.|.  ..|.| 
nrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGi

FKVKMDSVTETAEYVIRSFQLSEdGKETGQrsITQFHFLGWPDHGQPDYPSPMmCLIKRVR-------------HLTS---KMNHR---ANIVVHCSAGV
..|.  .  . . .  | ..||  | || .  .  ... || .   | |   .  | | ..              |.|   |  |       .. .. | 
ldverkefvkrniletrllelsk.Gnethr..vlhykvfGwtettlpkyedfl.alrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGs

GRTGTYIVIDAMLDMMKHEK--QVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
 |.|...||| .. ..   |     . ..|  ....|.  |    |. ||. ..|. 
araGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 16-122 7.4e-15 49.1 In-house 50-169 (349) alignment 
Range on Protein: 16-122
Range on HMM: 50-169/349.0
DKNRYINIIAYDHTRVKLK----PTDGIEG----------SDYINASYVNGYQ--SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKC
 |||| .|. |.|.|||||    .. .|.            ||||| |..  .     |.|| | |   |..||...|   .   .. |..  | . .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

SQYWPNKgviKYGRFKVKMDSVT
 .|| .    .|  ..||.    
diywqel...sysnitvklqnss
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 25-247 1.3e-20 68.8 In-house 29-256 (290) alignment 
Range on Protein: 25-247
Range on HMM: 29-256/290.0
AYDHTRVKLKPTDGIEGSDYINASYVNgYQSPDKFIAAQGPKDN-------TLEDFWRMIWEYNCSTIVMLTKCIEDGKD----KCSQYWPNK--GVIKY
   .||| ||       .||| |..|  . .  ..|. | |. .       |.|.|| |. . .   .||| .  |  ..     |..| |..  . .|.
LveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf

GRFKVKMDSVTETAEYVIRSFQLSEDGKEtgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVrhltskMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMK
. ..||  |  .  .  .|   .  |..|  .  .|   . || .   .. .  .. ||. |      ..... ..|||  |. |  .   |.    .. 
kgltvkCkskekeddvetRelvvkfddee..eftvtHsllkgWnklnvqedtktllsliqkv......kasktpvivHcvdGiSrsAalaaiilgyQkia

-HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
  ...| . . ....|.||.....|  .. |.  ...
etsgsvkledvlkalrkqralaitsalelafvdagiv
0044763 (Phosphotyrosine protein) phosphatases II 26-246 2.4e-37 123.6 In-house 2-167 (178) alignment 
Range on Protein: 26-246
Range on HMM: 2-167/178.0
YDHTRVKLKPTDGIEGSDYINASYVNGYqspdKFIAAQGPkdntlEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVikygrfkvkmdsvteta
.|.|||.| .  |.|.|||||||.. ..     ......|     .|......|.....||.||. .| |. || .||| .                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

eyvirsfqlsedgketgqrsiTQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmNHRANIVVHCSAGVGRTGTYIVIDAMLDMmkhekQVDIYNFIHDI
                      |......|||| || .. .. ... .... .  ..  ...|||||||||.|| .... |. .     ...... |. .
.....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielv

RQQRNtLVQSFVQYFFIHMAL
|..|.  |... |. ....  
rerRp.ivpnpgqlrqLyefe
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 26-158 2.3e-08 28.4 In-house 5-125 (130) alignment 
Range on Protein: 26-158
Range on HMM: 5-125/130.0
YDHTRVKlkptdgieGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDgkDkcsQYWPNKGVIKYGRFKVKMDSVT-ET
.. .|..        | .|||||.|   .   ... .| |  .|  |||.|. |     .|.|    |.  |   .|||.   ...   .. . .   . 
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee..d...eywpdsePlewyeediivtltdrde

AEYVIRS-FQLSEDGKEtGQRSITQFHFLGWPDHG
 ...  | .. ..| .|  ....| |.   ||  |
fknikasnleiesdlne.shqaltmfqisnwpsdg
0046846 (Phosphotyrosine protein) phosphatases II 38-247 4.8e-43 142.2 In-house 8-170 (176) alignment 
Range on Protein: 38-247
Range on HMM: 8-170/176.0
GIEGSDYINASYVNGYqspdKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNkgVIKYGRfkvkmdsvtetaeyvirsfqlsed
  ...|||||... |.    ..|| |||  .||.||..|..|......|.||...| |. || .|||   . |.|                         
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi........................

gketgqrsitQFHFLGWPDHGQPDYpSPMMCLIKRVRHLTSKMnhrANIVVHCSAGVGRTGTYIVIDamldMMKHEKQVDIYNFIHDIRQQRN-TLVQSF
          |...|.||||| ||. . .. |.. .|   ..     ...||||||.|||||.....    ....||...... .. .|.||    ||..
..........qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

VQYFFIHMALL
 || |.....|
eQyrflyefel
0051429 (Phosphotyrosine protein) phosphatases II 39-249 2.5e-53 176.7 In-house 1-224 (272) alignment 
Range on Protein: 39-249
Range on HMM: 1-224/272.0
IEGSDYINASYVNGYQS---PDKFIAAQGPKDNTLEDFWRMiWEYNCSTIVMLTKCIEDGKDKCSQYWP------------NKGVIKYGRFKVKMDSVTE
.. |.||||..|.|| .   |.......|| ..| .||||. .|....|||.|... | |..||..|||                | ||.. |.. |.. 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

TAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDypSPMMCLIKRVRHltskmnhRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVD------
.  |..| ..|.   . .  | ....|...||||| |.  ...  |.. ...         ...||||||..||||..... .|  . .|  ||      
lldyilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--IYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
  ...... .|.||   ||.  || |...|||| 
lyleeaveelraqrpgavqteeqylflyeallel
0043147 (Phosphotyrosine protein) phosphatases II 40-244 1e-45 150.9 In-house 3-155 (172) alignment 
Range on Protein: 40-244
Range on HMM: 3-155/172.0
EGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCiedgkdkcsqywpnkgvikygrfkvkmdsvtetaeyvirsfqlsEDGK
||||||||||...|  ||.||| ||| .|||.|||||..|.....||.||..                                            .  .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

ETGQRSITQFHFLGWPDHGQPdYPSPMMCLIKRVRHLTsKMNHRANIVVHCSAGVGRTGTYIVIDAMLdmmkheKQVDIYNFIHDIRQQRNTLVQSFVQY
|  .|.. |...|.||||| |  .. .. ... ...|    .    ..|||||||||||| .... ||      ....... .. .|..|.  ||.. ||
ellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

FFIHM
 |...
rflyy
0036282 (Phosphotyrosine protein) phosphatases II 41-243 5.2e-48 158.3 In-house 1-163 (174) alignment 
Range on Protein: 41-243
Range on HMM: 1-163/174.0
GSDYINASYVNGYQSPDKFIAAQGPKDntledFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNkgvikygrfkvkmdsvtetaeyvirsfqlsedGKE
||||||||.....  ....|| ||| .     ||.|..|....|.|||....|.|. || .|||                                  .|
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

TGQRSITQFHFLGWPDHGQPDYPSpMMCLIKRVRHLTSKmNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKhEKQVDIYNFIHDIRQQRNTLVQSFVQYF
   |.. |...|.||||| || .  .  ..|.|..  |. ..   ..|||||||||||| .... || ... |. ||...... .|.||   ||.. || 
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FIH
|..
fly
0051082 (Phosphotyrosine protein) phosphatases II 41-247 6.3e-38 125.1 In-house 2-150 (151) alignment 
Range on Protein: 41-247
Range on HMM: 2-150/151.0
GSDYINASYVNGYqspdkFIAAQGPkdntLEDFWRMIWEYNCSTIVMLTKCIEDGkdKCSQYWPNKGvikygrfkvkmdsvtetaeyvirsfqlsedgke
 |||||.||| |.     ... .||    |.||.....|....|||.|..  | |  .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

tgqRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltskmNHRANIVVHCSAGVGRTGTYIVIDAMLdMMkhekqVDIYNFIHDIRQQRNTLVQSFVQYF
   . ......|.|||.| |...  .. ... ...     .   ...||||||.||||| .... || ..     |...  ....|..|  .||.. |..
...ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqfl

FIHMALL
|...|||
fqlfall
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 44-244 1.1e-09 31.4 In-house 102-303 (346) alignment 
Range on Protein: 44-244
Range on HMM: 102-303/346.0
YINASYVNGYQSPDKFIAAQGPK---DNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIKY-GRFKV---KMDSVTETAEYVIRSfqLSE
..   |.  .|   |.| || |.   .  .|||| ||.. .   . ..       .   | .  ..|  .| |.. .   . |   .  || |    | |
hlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytiev..lpe

dGKetGQRSITQFH-FLGWPDHGQPDYPSPMMCLIKRvrHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQS
 |.   .  | | |    |    ||    |.. .|..   |. |  . | . |    | ||. ..|     .. .    . .|.. ...|.|||   |.|
.gn..sdsvicqvhhhapwkhlqqppktlpiikmihq..flsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggves

FVQYFFIHM
| ||  |. 
faqyasiya
0049260 (Phosphotyrosine protein) phosphatases II 49-243 1.2e-44 146.9 In-house 1-143 (152) alignment 
Range on Protein: 49-243
Range on HMM: 1-143/152.0
YVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWpnkgvikygrfkvkmdsvtetaeyvirsfqlsedgketgqrsitQ
...||  | .|||.||| .|||.|||||..|....||||||.. |.||.|| ||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

FHFLGWPDHGQPDYPSPMMCLIKRVRHLtsKMNHRANIVVHCSAGVGRTGTYIVIDAMLdmmkheKQVDIYNFIHDIRQQRNTLVQSFVQYFFIH
...| ||||| || .  .. |.. ...|  . .   ...||||||||||||..... ||      ..|......  .|..|.  |... |..|..
ylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 51-123 6.2e-13 42.9 In-house 230-300 (440) alignment 
Range on Protein: 51-123
Range on HMM: 230-300/440.0
NGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCiEDgkDKCSQYWP-NKGVIKYGRFKVKMDSVTE
.||   . |||.| | | |. ||||.. .|. |||.|| .  .|    || ||| |   . .| | |      .
egyskknafiatqmpldstvldfwrlvhdyristiimlnql.nd..ktcsiywpvntrsvtfgpftvghkgsen
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 57-243 2.1e-23 77.5 In-house 5-197 (199) alignment 
Range on Protein: 57-243
Range on HMM: 5-197/199.0
DKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN--KGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGK-ETGQRSITQFHFLG
 ..||.| |  .|. |||.|.||     |||.     . .   . |||    |. ||| . |   ..|  ..|.| .. |...       | |... |  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGQPDYpSPMMCLIKRVRHLTSKMN--HRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEK--QVDIYNFIHDIRQQRNTLVQSFVQYFFIH
| ..  |.  . .. ..   | .. | .  . | ..|||| | | || .. .|  .   .  |   ||...  . .|| |  .. |. .| ||.
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 58-243 2.4e-23 77.4 In-house 5-196 (198) alignment 
Range on Protein: 58-243
Range on HMM: 5-196/198.0
KFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN--KGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGK-ETGQRSITQFHFLGW
..||.| |  .|| |||.|.||     |||.     . .   . |||    |. ||| . |   ..|  ..|.| .. |...       | |... |  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGQPDYpSPMMCLIKRVRHLTSKMN--HRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEK--QVDIYNFIHDIRQQRNTLVQSFVQYFFIH
 ..  |.  . .. ..   | .. | .  . | ..|||| | | || .. .|  .   .  |   ||...  . .|| |  .. |. .| ||.
kekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 62-244 3.8e-30 99.4 In-house 96-282 (302) alignment 
Range on Protein: 62-244
Range on HMM: 96-282/302.0
AQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GVIKYGRFKVKMDSV-------TETAEYVIRSFQLSEDGKET-GQRSITQFHF
   || .||| .| .| .|| . .| |.. .||.. ||..|. .|  |..|.||. ||  ||       |.  .... . .. .. |..  ....  ..|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

LGWPDHGQPDYPSPMMCLIKRVRhltskmNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHM
 .||||| |. . . . ..|          .. |..|||||||||||| . |   ... ...|  |. . .  .|| |   ||.  |  .. .
sawpdhGapkeaytaldilkfce......sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 68-248 3.7e-22 73.6 In-house 39-219 (255) alignment 
Range on Protein: 68-248
Range on HMM: 39-219/255.0
NTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIKYGRFKVKMDSVTETAEYVIRSFQLS-EDGKETGQRSITQFHFLGWPDHGQPDYPSPM
 |.. |...|   . ...|||.   |.|..|||.|.| .   |    .|.. .   .|. |.|  ..  . |.    . .. ... ||...  |. .  .
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

MCLIKRVRHltSKmnhraNIVVHCSAGVGRTGTYIVIDAMLD-MMKH---E--KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
. ..| ||.  ||      .|||||.|.||. ...... .   |..        ..|  ......|..|.. ..  .|  |  . .|.
lnilkvvrd..sk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld
subfamily_hpo-7_pd Subfamily hpo-7 69-269 4.2e-19 63.5 In-house 46-243 (263) alignment 
Range on Protein: 69-269
Range on HMM: 46-243/263.0
TLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSE-DGKETGQRSITQFHFLGWPDHGQPDYPSPMM
|.. |...|   . ...|||.   |.|..|||.|.| .   |    .|.. .     . .... .| .  |.    . .... . ||... .|  .  ..
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

CLIKRVRHLtsKmnhraNIVVHCSAGVGRTGTYIVIDAMLD-MMKH---E--KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEehlFGHSDVAMPD
 ..| .|..  |     ..|||||.|.||.  . |.. .   |..        ..|  ......|..|.. ..  .|  |  . .|.   |   . |  .
nilkvarns..k.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd...fvlnnfakge

FPAYYQQL
  | ||..
leakyqei
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 98-235 7e-07 23.0 In-house 149-287 (332) alignment 
Range on Protein: 98-235
Range on HMM: 149-287/332.0
KCSQYWPNKGVIKYgRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSItQFHFLGWPDHGQ-PDYPSPMMCLIKRVRHLTSKMNH--RANIVVHCSAGV
 | ..||.|.  |     . ...  . .|  ...|.|.   |.  ....  .||  | |  . |.|   | . ||     .||        |.. |..||
icrkfwpekrskkd.fpalsiqasddhsethmktfnltvtekkqdhqtv.lmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcatgv

GRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQS
 .   .  || ..  .  |..| . . .  |. ||   ...
ekcaisatidiivsriteehrvgfketmsaikmqrfgcfrt
0048076 (Phosphotyrosine protein) phosphatases II 136-247 2.8e-23 77.6 In-house 37-140 (145) alignment 
Range on Protein: 136-247
Range on HMM: 37-140/145.0
EDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmnhRANIVVHCSAGVGRTGTYIVIDAMLDmmkhEKqVDIYNFIHDIRQQRNTLVQS
 . .|   | ..|...|.||||| || .. .. ... .... ..     ...||||||||||||..... ||     .. |.... .. .|.||   |..
tselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpn

FVQYFFIHMALL
. |. |.....|
pgqlrflyefel
PTEN_1 138-200 1.7e-09 32.8 In-house 87-147 (196) alignment 
Range on Protein: 138-200
Range on HMM: 87-147/196.0
GKETGQRSITQFHfLGWPDHGQPDyPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTY
 .|  .. ... | ....||| |.  | ... .|.. .  .. ... ...||| ||.||.|| 
leeffksgveylh.fpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtv
0048179 (Phosphotyrosine protein) phosphatases II 142-244 7.2e-23 76.3 In-house 45-139 (144) alignment 
Range on Protein: 142-244
Range on HMM: 45-139/144.0
GQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmnHRANIVVHCSAGVGRTGTYIVIDAMLdmmkHEKqVDIYNFIHDIRQQRNTLVQSFVQYFF
  | ..|...|.||||| ||... .  ... .... .   .  ...||||||||||||..... |.    ... ..... .. .|..|   |... |. |
leregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrf

IHM
...
Lle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 143-286 1.3e-25 84.7 In-house 88-229 (440) alignment 
Range on Protein: 143-286
Range on HMM: 88-229/440.0
QRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFI
 |.. |.|. ||||.| | . .|.. .|. | .   |    . ..||||||.||||  |..|..|   |.  |.||..||  .|..|  .||.  || |.
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDdDLTKLEVEF
| |.||  | | . .   |     .|.   . .  | . |. ||
heavlegllcgdtliledditerveqiqwpnpht.dksplqqef
subfamily_PTPDC1_pd Subfamily PTPDC1 144-238 8.7e-09 30.1 In-house 81-164 (182) alignment 
Range on Protein: 144-238
Range on HMM: 81-164/182.0
RSITqFHFLGWPDHGQPdypsPMMCLIKRVRHLTSKMNHRaNIVVHCSAGVGRTGTYIviDAMldmMKHEKQVDIYNFIHDIRQQRNTLVQSFVQ
. |. .. .||.|.| .    ..  ..  |. ... ...  .. ||| || ||||  |   ..   . . |...  . |. .|..|   .|.  |
qgiy.vynfgwkDygva....sleriLdivkvvafalqeg.kvavhChaGlGrtGvli..acy...lvyakrltaekaiklvrskrpksiqtreq
PTPc_DSPc_SM00012 146-248 9.4e-35 114.4 In-house 2-105 (105) alignment 
Range on Protein: 146-248
Range on HMM: 2-105/105.0
ITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKHE-KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHM
....|..|||||| |....... |.. |.. ..| ......|||||||||||||....| .|.....| |.|||..... .|.||...||.. ||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 148-247 6.2e-13 43.2 In-house 219-341 (350) alignment 
Range on Protein: 148-247
Range on HMM: 219-341/350.0
QFHFLGWPDHGQPDYPSPMMCLIK--------RVRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLD-------MMKHEKQVDIY--------NFIHD
|...  |.| .    |  ..  ..         . .. .. .. . |.||||||||||||.. .| .|        . |. ...|            .  
qlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivne

IRQQRNTLVQSFVQYFFIHMALL
.|.||  .||.  |. ||. |||
lrkqrismvqnldqfifiYeall
0038934 (Phosphotyrosine protein) phosphatases II 148-204 7.2e-08 27.8 In-house 81-136 (194) alignment 
Range on Protein: 148-204
Range on HMM: 81-136/194.0
QFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHrANIVVHCSAGVGRTGTYIVID
... | .||.| .   . ..  .. | . ... ..   ..||| ||.||||| ..  
eylklpfpddgtvPsleillrfldlvdeflnedpg.gvvaVHCkaGlgRtGtlvaaY
subfamily_CDKN3_pd Subfamily CDKN3 153-243 5e-06 20.2 In-house 106-189 (202) alignment 
Range on Protein: 153-243
Range on HMM: 106-189/202.0
GWPDHGQPDypsPMMClIKRVRHLTSKMNHRANIVVHCSAGVGRTGtyIVIDAMLDMMkhEKQVDIYNFIHDIRQQRN-TLVQSFVQYFFIH
  .| . ||   .  | .| .  |.  ..   . .|||  |.||.   .||  .| ..  . ...  . | ..|. .    .|.  || ...
piadglvpd...iasc.lkileelrinlkayrktlvhcygglgrss..lviaclllyl..ddtiepkdaidklrdlkgsraiqtvkqynyls
subfamily_DSP23_pd Subfamily DSP23 154-238 2.8e-06 22.0 In-house 54-134 (148) alignment 
Range on Protein: 154-238
Range on HMM: 54-134/148.0
WPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANI-VVHCSAGVGRTGTYIVIdamlDMMKhEKQVDIYNFIHDIRQQRNTLVQSFVQ
.   . .||  | .  ...  ..  . .....   |||  | ||||| .       ..| |...   . | ..|..|   |... |
lvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlac....ylvk.erklaaaeaiaevrrlrpgsvetveq
subfamily_PTEN_pd Subfamily PTEN 161-239 1.3e-07 26.8 In-house 89-169 (184) alignment 
Range on Protein: 161-239
Range on HMM: 89-169/184.0
DYPSPMMCLIK-RVRHLTSK--MNHRANIVVHCSAGVGRTGTYIVIdAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQY
|  .| . |..  |.....    ...  .|||| || ||||. ||   .| ... ||. .. .. . .| . .. |.   | 
DhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqr
subfamily_CDC14_pd Subfamily CDC14 168-239 7.8e-06 19.9 In-house 250-314 (328) alignment 
Range on Protein: 168-239
Range on HMM: 250-314/328.0
CLIKRVRHLTSKMnhRANIVVHCSAGVGRTGTYIVIDamldMMKHEKqVDIYNFIHDIRQQRNTLVQSFVQY
 ..|.  ... |.  . .|.||| ||.||||| |       .||| . .   . |  .|  |   | .  | 
aivkkfleiaeka..eGaiavhCkaGLGrtGtLiacy....lmkhyr.ftaaeaiawlricrPGsvigpqqk
PTPc_motif_SM00404 173-228 3.2e-06 22.1 In-house 70-123 (140) alignment 
Range on Protein: 173-228
Range on HMM: 70-123/140.0
VRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMldMMKHEKQVDIYNFIHDIRQQ
.. . .  . . ...||| ||| |..| |.   |  . .. .  . |.|... |..
ldfienaekkggkvlVHCqaGvSRSatliiaYlm..ryrqlslaeayefvkerRpi
DSPc Dual specificity phosphatase, catalytic domain 173-233 4.4e-06 21.6 Pfam-A 63-118 (133) alignment 
Range on Protein: 173-233
Range on HMM: 63-118/133.0
VRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMldMMKHEKQVDIYNFIhdiRQQRNTLV
|. . . .. . ...||| ||. |..| |.   |  . |. .  . |.|.   ...|....
vefiekaeqkgkkvlVHCqaGisRSatliiaYlm..ktknlslneAyefv...kerrskis
DSPc Dual specificity phosphatase, catalytic domain 173-233 4.4e-06 21.6 In-house 63-118 (133) alignment 
Range on Protein: 173-233
Range on HMM: 63-118/133.0
VRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMldMMKHEKQVDIYNFIhdiRQQRNTLV
|. . . .. . ...||| ||. |..| |.   |  . |. .  . |.|.   ...|....
vefiekaeqkgkkvlVHCqaGisRSatliiaYlm..ktknlslneAyefv...kerrskis
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 181-248 7.8e-10 32.6 In-house 263-342 (349) alignment 
Range on Protein: 181-248
Range on HMM: 263-342/349.0
NHRANIVVHCSAGVGRTGTYIVIDAMLDMM----KHEKQVDIYN--------FIHDIRQQRNTLVQSFVQYFFIHMALLE
.. . ..|||||| ||||... .| .|...    ..  .... .         .  .|.||  .|| . |. .|. |||.
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_CG42327_pd Subfamily CG42327 182-246 3.8e-13 43.8 In-house 246-311 (319) alignment 
Range on Protein: 182-246
Range on HMM: 246-311/319.0
HRANIVVHCSAGVGRTGTYIVIDAMLDMMKHE-KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMAL
..  .||||| ||||||. |  |  .  ...  . ||| . .. .|..|   |..  || ||.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 186-249 1.5e-16 54.6 In-house 1-64 (69) alignment 
Range on Protein: 186-249
Range on HMM: 1-64/69.0
IVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
.|||||.| |||||.| |   .  .| || |||.| .  .|. |  .|   ..| ||| || | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 187-249 1.2e-15 51.6 In-house 1-63 (69) alignment 
Range on Protein: 187-249
Range on HMM: 1-63/69.0
VVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
|||||.| |||||.| |   .  .| || |||.| .  .|. |  .|    .| ||| || | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
0050432 (Phosphotyrosine protein) phosphatases II 247-527 2.2e-86 285.3 In-house 9-300 (308) alignment 
Range on Protein: 247-527
Range on HMM: 9-300/308.0
LEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDDLTKLEVEFRRACKLGVnGTDQTFANIDQNKDKNRIGHILPFDKNVVKLerligEEFSDYINASFITGY
||  ||.. .. . ... ....| .. .  .||..|| ||.. ... .   . ..|.  .||||||  .|||.|.. |||     .| |||||||...||
lelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgy

--QRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLEID-ETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQ
   ... .||||||||||..|||||.||                   ||||||||.. ...| |...|||..| . .||.||| .|...   .. |....
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvth

YHFRGWPEVGVPESGIDLMRLVNKSHLHQkeqGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
.|. .||. |||.|  .|...... . ..   ...||||||||| ||||.|||| .|....|.| ..|||..|. ||.|||.|||.. |..|.| |..||
fhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley

LE
|.
lk
0051299 (Phosphotyrosine protein) phosphatases II 255-526 9.1e-85 279.9 In-house 3-286 (288) alignment 
Range on Protein: 255-526
Range on HMM: 3-286/288.0
SDVAMPDFPAYYQQLSnksdfDDDLTKLEVEFRRACKLGVNgTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIA
 .. . ..  ....|       ..||.|. ||.. ..| ..  ....|.  .|..|||  .|||.|.. |||  | |.|.|||||||.|.||..|. .||
teisveellklvlkll.....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

TQGPLPNTIADFWRMIW------------------EMCAQYWPLeiDETEEQGDISVTLVEESEeDDDFTVRDIEISHA----HMKDIRKIRQYHFRGWP
||||||||..|||||.|                  | |||||||  ..... |||.|||..| . .||.||| .|...       .  |.....|. .||
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwp

EVGVPESGIDLMRLVNKSHLHQKeQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
. |||.|  .|...... . ... .|..|.||||||| ||||.|||| .|....|.| ..||...|. ||.|||.||| . |..|.| |..|||
dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 256-531 2.7e-72 238.3 In-house 6-290 (293) alignment 
Range on Protein: 256-531
Range on HMM: 6-290/293.0
DVAMPDFPAYYQQLSNKSDFdddltKLEVEFRRACKLGVNgTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIAT
.. . .| .........||.     ..  |. .  ..| . . ...|.  .|..|||   |||.|.. |||. | .|. ||||||..| ||. .. .|||
piklekfeehvkkmkadsdl.....rfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QGPLPNTIADFWRMIWEM------------------CAQYWPLEIDeTEEQGDISVTLVEESEeDDDFTVRDIEISHahMKDIRKIRQYHFRGWPEVGVP
|||||.|. |||||.||                   | .||| . . .   |||.||||.|.|  .|...|...|..   |..||.|||||  ||. |||
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadee.pvlyGdikvtlvaeee.ledwvirelkiek..ekeerkvrqyhftsWpdhgvP

ESGIDLMRLVNKSHL-HQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQST
|.   |...|.. .  ..|..  .||||||||| ||||.||||. |....||| ..|.| .|  ||..| ..||  .|. | .......|.....
ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 260-532 4.5e-68 224.7 In-house 8-296 (298) alignment 
Range on Protein: 260-532
Range on HMM: 8-296/298.0
PDFPAYYQQLSNKSDfDDDLTKLEVEFRRACKLGV--NGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQG
.|. |  |.|....  . .||... ||.|  .     . . .. |. ..||.|||   |...|.  | ||.  ..| ||||||||. .|...| .||||.
edlkaalqklaavkk.kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqa

PLPNTIADFWRMIWE------------------MCAQYWPLEidETEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPES
||..|..|||||..|                   . .||| |  ..|. |.|.|.| . .||  |..|| ...|... .. |..|| ||  ||. |||| 
PltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvslls.keefadlivrklkvskkkeekerevrqlhftsWpdkgvpen

GIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTE
   .. |..| . .|.. | ||..|.|||| ||.| |||.. .. |...|...||||.|. ||..||..||  .|..|.|.|. |.|.  ..|
atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
0045450 (Phosphotyrosine protein) phosphatases II 261-527 3.8e-77 255.3 In-house 8-305 (307) alignment 
Range on Protein: 261-527
Range on HMM: 8-305/307.0
DFPAYYQQLSNKSDFDDDLTKLEVEFRRACKLGVN-GTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGE-EFSDYINASFI--------TGYQRKN
  .|..  |  . .  |.||.|. ||.. ... |    . ..|.  .||||||. .|||.| . |||  | |. | |||||||..         || .|.
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

MYIATQGPLPNTIADFWRMIWEM------------------CAQYWPLEiDETEEQGDISVTLVEESEeDDDFTVRDIEISHA-HMKDIRKIRQYHFRGW
 .||||||||.|..|||||.||                   ||||||.| .|. . |.. |||..|.. .|..||| .|...    .  |.....|. ||
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgw

PEVGVPESGIDLMRLVNKSHLHQKEQ-GPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESM---IDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
|. |||.|  .| ..... . ...|  ...|..|||||| ||||.|||. ......|.| .   .|....|. ||.|||..|| . |..|.| |. |.| 
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 265-526 5.7e-151 497.3 In-house 19-292 (319) alignment 
Range on Protein: 265-526
Range on HMM: 19-292/319.0
YYQQLSNKSDFDDDLTKLEVEFRRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIA
|||||||||||||||||||||||||||||||..||||||.|||||||||..||.||||||||||||||||||||||||.||||||..|||.||||.||.|
yyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntla

DFWRMIWE------------MCAQYWPLEIDETEEQGDISVTLVEESEEdddFTVRDIEISH-AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNK-S
||||||||            .|.|||||.|...||.....|..|||..|   ..|||||.|. ...||||||.|.||.|||.||||....||||||.| .
dfWrmiweyncstivlltkdkcsqywplkivikeerfkvkvdsveetae...yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvr

HLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE-YL
||..||.....||||||||.|||||.|.|.||..||.||...||...||.|||||...||||.|.||.|||..| .|
hltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_PTPN23_pd Subfamily PTPN23 268-528 1.2e-54 180.1 In-house 10-282 (288) alignment 
Range on Protein: 268-528
Range on HMM: 10-282/288.0
QLSNKSDFDDDLTKLEVEFRRAcklgvnGTDQTFANIDQNKDKNRIGHILPFDKNVVKLErligEEFSDYINASFITGYQRK-NMYIATQGPLPNTIADF
.|..|. .|    .|| .  .         ... |    . .|||   |||.|.| |||.    ..  |||||||. .       .||||.||..|..||
mldgktaldkkfkeleqkqdke......arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WRMIWE------------------MCAQYWPLEIDETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVN
|.|..|                   ...||| . .||.. ||.|||| .. |  . .  |...... . . .....  ..  |||.|||.|  .|.....
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre.tethvervlkletldadavksvshlqltsWpelGvPasPetllqfld

KS---HLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMS-RMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
.    . .....  .|.|||||||.||||||  .   .    ... ..|. | |. ||.|| .|||. .|.||.|.|..|. ..
evesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
0039614 (Phosphotyrosine protein) phosphatases II 269-527 1.1e-76 253.4 In-house 21-290 (297) alignment 
Range on Protein: 269-527
Range on HMM: 21-290/297.0
LSNKSDFDDDLTKLEVEFRRACKLGVNgtdQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGE-EFSDYINASFITGYQR-KNMYIATQGPLPNTIADF
| .. .  .. |.|. || . ..| ..   ...|.  .||||||. .|||.| . |||  . |  . |||||||...|| . .. .||||||||.|..||
lllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedF

WRMIWEM-----------------CAQYWPLEIDeteEQGDISVTLVEESEeDDDFTVRDIEISHahMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNK
|||.||                  |||||| | .   . ||..|||... . .|..||| .|...   .  |....... |||. |||.|  .|......
wrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflel

SHLHQKEQ-GPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
 . ...|  ...|..|||||| ||||.|||.  .....|.|  .||...|. ||.|||..|| . |..|.| |..|.| 
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_PTPRN_pd Subfamily PTPRN 270-525 8e-52 170.8 In-house 19-291 (297) alignment 
Range on Protein: 270-525
Range on HMM: 19-291/297.0
SNKSDFDDDLTKLEVEFRRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQ-RKNMYIATQGPLPNTIADFWR
|   |.  . ..|| |.   |.   . . .. |. ..| .|||  ..||.|.. |||..   .| |||||||.|.  . |. .||||||||..|.||||.
syledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwq

MIWE------------------MCAQYWPLEIDETEeqGDISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESG---IDLMRLV
|.||                   |..||| |  |.   .   | || |    ||. || . .   . .. | . |.||  ||| ||| |    ... | |
mvweqGvvvivnltrleeegvkqckrywpdeGsevy..hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkv

NKSHLHqkeqGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEE-SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
|||.         |||||||.|.|||||.|.......|.      ||.  |.  ||.|||..|.  .||.|...|..| 
nksyrG....rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_PTPN12_pd Subfamily PTPN12 272-530 1.9e-67 222.2 In-house 7-281 (290) alignment 
Range on Protein: 272-530
Range on HMM: 7-281/290.0
KSDFDDDLTKLEVEFRRACKLGVngTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIW
. .|  . .||  . ..  .  |    .. .. ..|. |||   |||.||. |.|..  .|| ||||||.|| | . | .|||.|||||.|. |||||||
eeefakefqklkklsekykaekv..ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

EM------------------CAQYWPLEIDETEEQGDISVTLVEESEEDDDFTVRDIEISHAhmKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLH
|.                  |..||| | .|. | |...||| ||   ||||..| ... .   |. ||..|.|.. ||. |||.|  .|..|... . .
eknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrel

QKeQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESM---IDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQS
|. .  .|.||||||| ||||. ||..   . ...| .   .|||. |. ||.||. .||   |... | |..|..... 
qe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkel
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 274-531 3e-43 142.7 In-house 16-298 (301) alignment 
Range on Protein: 274-531
Range on HMM: 16-298/301.0
DFDDDLTKLEVEFRRACKLGVNgtdqtfaniDQNKDKNRIGHILPFDKN--VVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIW
.|... ..|. .  . |..|..         ..||  ||  .| ..|.|  ..| .. .     .|||||.| ||..|. .||.|||. .|..||||.||
kfeeqykelkegedksctvgls.........eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

E------------------MCAQYWPLEIDETEEQGDISVTLVEESEEdDDFTVRDIEIS---------------HAHMKDIRKIRQYHFRGWPEVGV-P
.                   | ||||    |.|| | ..||||.|     ||..|.. .                  . |. ... |..   ||. || .
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvy.PdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr

ESGIDLMRLVNKSHLHQKeQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQST
|    |. . .  |  ||  |  |.|||||.. .|.||...... .     |  .|||| .. .|...| .|. | |. . | .. .||. .||
eprtvLqviddvihrqqk.igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 275-532 1e-28 95.3 In-house 11-283 (307) alignment 
Range on Protein: 275-532
Range on HMM: 11-283/307.0
FDDDLTKLEVEFRRACKLGVNGTdqTFANIDQNKDKNRIGHILPFDKNVVKLErlIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE--
.|  ...|  |||  .|   .|   |   .. | ||||   .   ||. . ..  .    |||| | ..    . . .|..|||| ||. .|| |. .  
ldkgvqalvdefrvlakktpegv..tveafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqek

----------------MCAQYWPLEIDETEEQGD----ISVTL--VEESEEDDDF-TVRDIEISHAhmKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNK
                 | ||||||  ..   |.    |||.   ...   |.|.  | ....  |  .. | |... .  ||. |||.  .  . |.. 
vesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa..qksrtiqhlqwenwpdrgvpqinltainllea

SHLHQkeqgpKPIVVHCSAGSGRTGVFIALNVLMSRM-EEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTE
 . ..      |.||||||| ||.|  .|. ... .| . .   |. . |. ||.||.. .|. ||. . .  ..||. |.  |
vrydt.....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyke
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 275-530 7.3e-27 88.8 In-house 19-293 (305) alignment 
Range on Protein: 275-530
Range on HMM: 19-293/305.0
FDDDLTKLEVEFRRACKLGVNGTDQTFANIDQN----KDKNRIGHILPFDKNVVKLERLIgeeFSDYINASFITGY-QRKNMYIATQGPLPNTIADFWRM
.|  . ||  |||. .|       |.  | .|     . |||   .   |...|||..      |||| | ..      .. .|..|||| .|| .|| |
ldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwm

IWE------------------MCAQYWPLEIDETEE-QGDISVTLVEES---EEDDDFTVRDIEISHAHMKDIrKIRQYHFRGWPEVGVPESGIDLMRLV
. .                   ||||||.   |  | .. | |  |  |   | | .  .  ......  . .  .|. ..  ||. |||   .  . |.
viqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkm.svrhlqwtewpdrgvppckltslell

nkSHLHqkeQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMI-DVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQS
  | .        ||||||||| ||||  .|.. .. .. |.     . . |. ||.|| . .|.  |. | .  |..|. |. 
..sair...gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
0047943 (Phosphotyrosine protein) phosphatases II 277-526 1.2e-80 266.2 In-house 9-272 (273) alignment 
Range on Protein: 277-526
Range on HMM: 9-272/273.0
DDLTKLEVEFRRACKLGVnGTDQTFANIDQNKDKNRIGHILPFDKNVVKLerliGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE----
..||.|. ||.. ..| .   . ..|.  .||||||. .|||.|.. |||    |.. |||||||...||..|. .||||||||||..|||||.||    
lgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

--------------MCAQYWPLEIDE-TEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQ
               |||||||| .| ... |...|||..| . .||.||| .|... . .. |.....|. |||. |||.|  .|...... . .... 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-GPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
 ...|.||||||| ||||.|||| .|....|.| ..||...|. ||.|||.||| . |..|.| |..|||
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 277-526 2.9e-75 248.6 In-house 17-277 (278) alignment 
Range on Protein: 277-526
Range on HMM: 17-277/278.0
DDLTKLEVEFRRACKLGVngTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE----
.. |.|. || . ..  .   ....|.  .||||||. .|||.| . |||. | |.. |||||||...||.... .||||||||.|..|||||.||    
nlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvt

--------------MCAQYWPleiDETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKeQG
               ||||||   ..... ||..|||..| . .||.|||..|...   .  |....||. |||. |||||  .|...... . ...   
tivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.ds

PKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
..|..|||||| ||||.|||| .|....| |  .|....|. ||.|||..|| . |..|.| |. |||
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 277-372 6.6e-30 99.1 In-house 29-123 (330) alignment 
Range on Protein: 277-372
Range on HMM: 29-123/330.0
DDLTKLEVEFRRACKLGVNGTDqTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE
||  ..  ||       ...|    |. ..||.|||. .|||.| . | |  . |.| ||||||||| ||..|. .||.|||. .|. ||||||||
ddnklfreefnalPagpiqatl.elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiwe
0036941 (Phosphotyrosine protein) phosphatases II 278-529 8.5e-80 263.5 In-house 11-280 (297) alignment 
Range on Protein: 278-529
Range on HMM: 11-280/297.0
DLTKLEVEFRRACKLGVNGTdQTFANIDQNKDKNRIGHILPFDKNVVKLerliGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE-----
.|..|. ||.. ..| ..|.  . |.  .|..|||  .|||.|.. |||    ..| |||||||...||..|. .||||||||||..|||||.||     
flalllkefeellpllllgs.lsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

-------------MCAQYWPLEIDETEEQGDISVTLVEESE-EDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQ-
             .||||||||..|. . ||..|||..... ..||.|.| .|...   .. |.....|. |||. |||||  .|...... . ..|.  
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

GPKPIVVHCSAGSGRTGVFIALNVLMSRME---EESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
...|..|||||| ||.|.|||. ......|   .|  .|....|. ||.|||..|| | |..|.| |. |.|  .
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0040438 (Phosphotyrosine protein) phosphatases II 278-529 2.3e-79 262.3 In-house 16-279 (317) alignment 
Range on Protein: 278-529
Range on HMM: 16-279/317.0
DLTKLEVEFRRACKLGVNgtDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE-----
| |.|. ||.. ..| ..  . ..|.  .||||||. .|||.| . |||  | | . |||||||...|...|. .||||||||||..|||||.||     
dftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

-------------MCAQYWPLeiDETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKeQGP
             .|||||||  .|| . ||..|||..| | ....|.| .|...   .. |.....|. |||. |||.|  .| ..... . ... ...
ivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpg

KPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
.|..|||||| ||||.|||. ......|.|  .||...|. ||.|||..|| ..|..|.| |. |||   
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 278-532 5.4e-67 221.1 In-house 20-289 (305) alignment 
Range on Protein: 278-532
Range on HMM: 20-289/305.0
DLTKLEVEFRRACKLgvnGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM----
. ..||....  ...   ..     . ..|| |||  .| ..|.. ..|     .. |||||||.. ||.||. ||..||||.||.|||||.|.|.    
sdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

--------------CAQYWPLEIDETEEQGDISVTLVEEsEEDDDFTVRDIEISH-AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQG
              | |||| .. |..| |..||.| .| ..  |.. |...||   . |. | . ||..  ||. |||..   |..|... . .||.. 
ivmltklveggkdkCrqYWpesktekkefgefsvelkse.ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

PKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTE
 .|..|||||| ||||||||... . |...| ..|||. .. ||..|. ||| |.|. |.. |. |...   |.
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdts
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 278-528 4.7e-39 129.0 In-house 4-261 (267) alignment 
Range on Protein: 278-528
Range on HMM: 4-261/267.0
DLTKLEVEFRRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEefsdYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM----
. ...| ||    |.  . .  .     .|...||. . ||.|...| |     |    |||||.. ||..||..|.||.|| |||.||. .| .     
eeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpv

-----------CAQYWPLEIDETEEQGDISVTLVEESEEDdDFTVRDIEISHAHmKDIRKIRQYHFRGWPEVGVPEsgIDLMRLVNKSHLHQKEQGPKPI
             ..|| .. ....  |..|    | ||. |. .  .|.     .  ...  |... |      .    |  |.      | |.| .|.
ivlltkvftdnirlfwPPkmgqakkyqdltvehslekeen.dyqiitlelkfkn.esahnvtlyyykkwnintnnk..pylkplfgilaknqlengnrPl

VVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
||.||.| ||.| |. ..  . |. .|.. |.|. .| .|.||. .|. . .. ...  ..|| | 
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 280-534 7e-73 240.5 In-house 23-291 (319) alignment 
Range on Protein: 280-534
Range on HMM: 23-291/319.0
TKLEVEFRRaCKLGVNGtDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM------
|.|| ||.   | .||  . . |. ..||.|||   ||..|.  |.|  | | | ||||||||| |||... .||||.|| ||| |||||.||       
tllekefkl.lkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

------------CAQYWPLEidETEEQGDISVTLvEESEEDDDFTVRDIEIsHAHMKDI--RKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGP
            . .||| |  . || | . ||| || || .|. .|.... . .  ..  |.. ....  ||. .|||..  |. |... .  ....  
mltklveklkvklkkywpee..nfeeyGrlivtl.eeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqs

KPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEYQ
.|||||||||.|||| ||.|.. . |..||...|||.||. || ||. |||  .|.||.| |..|..|  .||..
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteie
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 281-530 4.9e-69 227.6 In-house 22-283 (288) alignment 
Range on Protein: 281-530
Range on HMM: 22-283/288.0
KLEVEFRRACKLGVNGTdQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE--------
 .. |..   .|. . . .| ..  .|..|||   |||.| . |||. |  |. .||||||.| |...|. ||||||||..|. |||....|        
gfseeynsLaalektks.vtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivm

---M-------CAQYWPLEiDETEEQGDISVTLVEESEeDDDFTVRDIEIShaHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQgPKPI
   .       | .||| . |. .. |.. |||||. |  .||..| ...   . |. ..| ||.. .||. |||||  .|. |... .  ....  .||
ltelveggktkCeeYWPda.dkpknyGsvtvtlveske.ledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpi

VVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQS
.|||||| ||||.||||. |. ..||| .|||. ||  ||.||. .|| | |. |.|.....  ||..
ivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg
subfamily_CG7180_pd Subfamily CG7180 281-526 3.6e-49 162.0 In-house 14-290 (296) alignment 
Range on Protein: 281-526
Range on HMM: 14-290/296.0
KLEVEFRRACKLG--VNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------
| .||..  .||   ..  |   .   .|..|||  ...|.|.| | ||.| |||.||||||... .. .|. || |..|  .|. .|||....      
kfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisav

-----------MCAQYWPLEIdeTEEQGDISVTLVEEsEEDDDFTVRDIEISHA----------HMKDIRKIRQYHFRGWPE-VGVPESG---IDLMRLV
           |. .||| .    |. |.| | .||| ..  ... | . . .              . | ....... |.    || |    |.|.| |
vvLtktfdfakmypsywpnks..keqygeifveivee.kqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

NKSHLHQ-KEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
..   .  ...  .|.||..| |..|.||..|... .  .|.|  .|||. |. ||..||..|.   ..|..|  . |..
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_ptpA1_pd Subfamily ptpA1 281-374 2.4e-20 67.7 In-house 22-113 (418) alignment 
Range on Protein: 281-374
Range on HMM: 22-113/418.0
KLEVEFRRaCKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNmYIATQGPLPNTIADFWRMIWEMC
|.. |||   .  |  .. .  .  .|  |||   ||| ..  |.|...  .| |||||| .| |   |. .|.|||||||||||||||.||  
kikeefrl.leesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenr
0046845 (Phosphotyrosine protein) phosphatases II 282-528 1.6e-82 272.4 In-house 2-276 (284) alignment 
Range on Protein: 282-528
Range on HMM: 2-276/284.0
LEVEFRRACKLGVNGT-DQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGE-EFSDYINASFITGY-----QRKNMYIATQGPLPNTIADFWRMIWE--
|| ||.. ..| |. . . ..|.  .|..|||  .|||.|.. ||| .| |. | |||||||...||      .|. .||||||||||..|||||.||  
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

----------------MCAQYWPLEiDETEEQGDISVTLVEESEeDDDFTVRDIEISHAH-MKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQK
                .|||||||| .|. . ||..|||..| . .||.||| .|... .  .  |.....|. .||. |||.|  ||...... . ...
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

E-QGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEES---MIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
.  |..||||||||| ||||.|||| .|....|.|.   ..||...|. ||.|||.||| |.|..|.| |..|||  
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_PTPRG_pd Subfamily PTPRG 282-532 2.2e-65 216.0 In-house 21-293 (563) alignment 
Range on Protein: 282-532
Range on HMM: 21-293/563.0
LEVEFR-RACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFS-DYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE-------
.. ||     .   .  | ....  .|| |||   |...|.  |||. | |.. . |||||..| |||... .|||||||..|. ||||||||       
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv

-----------MCAQYWPLeiDETEEQGDISVTLVEEsEEDDDFTVRDIEISHAHMKDIR------KIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQK
            | .|||   ||.|. | ..|||.|| |     ||| . | . ..|. .      ..||||.  ||..||||. .  .  |.||   .|
mitnlvergrrkcdvYWPk..desetygalqvtliee.evlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaank

E-QGpkPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTE
.  |  ||||||||| ||||..|.|. |. ....|....||.... .| ||...||.  |. | . |..| .  . ||
aeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 282-529 2.6e-56 185.8 In-house 17-279 (281) alignment 
Range on Protein: 282-529
Range on HMM: 17-279/281.0
LEVEFRRACKLGVNGTDQTfANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM--------
.  |..   ..||. | .  .. |.|. |||   |  .|.  ||...   .. .|||||.|. ||. .. |||||||.|.....||.|.||         
fieeyeklaaigvdntata.skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmv

----------CAQYWPlEIDETEEQGDISVTLVEEsEEDDDFTVRDIEIsHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIV
          | .||| . ... . ||. |. ..| ||   .  | ... ...  . |...| ..  ||. |||..  .|.   .. .  ....   |.|
treieagklkChrYWP.ddnselkygdvtvkstae.eekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplv

VHCSAGSGRTGVFIALNVLMSRMEEE-SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
.||||| ||||..|||. |....|.| ...|| ..|. ||..|  ||| ..|..| | |....|...
ihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 282-533 6e-49 161.4 In-house 12-284 (287) alignment 
Range on Protein: 282-533
Range on HMM: 12-284/287.0
LEVEFRRACKLGvNGTDQTFANID--QNKDKNRIGHILPFDKNVVKLERlIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE-------
.. |. . ..   ...  || . .   .  ||| ...||.|.. | |    ||  |||||| ....|.... .||.|||.. |. ||||...|       
vdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

-M----------CAQYWPLEiDETEEQGDISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKS--HL--HQKEQ
 |          | .|||   .     |  ||.|.. .  . ...|| . . ... .. | ..|...  ||. ... . . |.|.| .   |.   .. .
tmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardas

GPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEY
.  |.|||...| ||.|...|. ||.||.|.   .|| ..|  ||..|  .||   |... | |.| | . .   |
evGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnpqly
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 282-524 9.5e-49 160.8 In-house 8-264 (283) alignment 
Range on Protein: 282-524
Range on HMM: 8-264/283.0
LEVEFRRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGeefsDYINASFIT---GYQRKNMYIATQGPLPNTIADFWRMIWE------
 .. . .  .|.|   | . |  |.|| |||  .|.| |...|.|. .      |||||.||.    |.... ||..|.|| .|. |||.|...      
nklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

------------MCAQYWPLEidETEEQGDISVTLVEESEEdDDFTVRDIEISHA-HMKDIRKIRQYHFRGWPEVGvPESGIDLMRLVNKSHLHQKEQGP
             |.|||| .   .|. |.  ||| .|  . . |... . . .    |.   .  | . .| |.| ... |. .  .||    |.|.  
vmltklqedlrikCsqyWPkr..GsedyGeftvtlrketts.nsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskk

KPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
 |||||||.| |||.||||. . .  .  ||..|||..|. .|.||. .|| | |.|. . ...|
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 283-526 5.1e-140 460.9 In-house 1-256 (284) alignment 
Range on Protein: 283-526
Range on HMM: 1-256/284.0
EVEFRRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE----------
|||||||||||||||||||||.|||||||||||||.|||||||||||||||||||||||||||||||..||||||||.||.|||||||||          
evefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt

--MCAQYWPLEIDETEEQGDISVTLVEESEEdddFTVRDIEISH-AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNK-SHLHQKEQGPKPIVVHCSA
  .|.|||||.|...||.....|..||||||   ..|||||.|. ...||||||||.||.|||.||||....||||||.| .||..||.....|||||||
kdkcsqywplkivikeerfkvkvdsveesee...yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

GSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE-YL
|.|||||.|.|.||..||.||...||...||.|||||...||||.|.||.|||..| .|
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_PTPN14_pd Subfamily PTPN14 283-376 1.1e-18 62.3 In-house 26-119 (300) alignment 
Range on Protein: 283-376
Range on HMM: 26-119/300.0
EVEFRRACKLGVNGTDQTfANIDQNKDKNRIGHILPFDKNVVKLERLIgEEFSDYINASFITG--YQRKNMYIATQGPLPNTIADFWRMIWEMCAQ
 .|. |  |   ... .| |. ..|..|||. ..||...| |.|     |. ..||||| |      ..  ||..||||..|. |||.|.||   |
fteyeripkkredallst.aklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq
DSPc_SM00195 284-526 3.5e-74 244.8 In-house 4-262 (263) alignment 
Range on Protein: 284-526
Range on HMM: 4-262/263.0
VEFRRACKLGVNGtDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM----------
 ||..  .   .  . | |....||.|||  .|||.|.. |||..  ..| ||||||..|.|...|. |||||||||.|..|||||.||.          
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

--------CAQYWPLEIDETEEQGDISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQgPKPIVVH
        |..||| |....|. |.|||.|||. ...|....|..|...   .. ||..||....||. |||.|  ....|... . .....  .|||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVh

CSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|||| ||||.|.......|..|||...|.|..|. ||.|||.||| |.|..|.| |..||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 284-526 3.5e-74 244.8 In-house 4-262 (263) alignment 
Range on Protein: 284-526
Range on HMM: 4-262/263.0
VEFRRACKLGVNGtDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM----------
 ||..  .   .  . | |....||.|||  .|||.|.. |||..  ..| ||||||..|.|...|. |||||||||.|..|||||.||.          
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

--------CAQYWPLEIDETEEQGDISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQgPKPIVVH
        |..||| |....|. |.|||.|||. ...|....|..|...   .. ||..||....||. |||.|  ....|... . .....  .|||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVh

CSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|||| ||||.|.......|..|||...|.|..|. ||.|||.||| |.|..|.| |..||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Ptp69D_pd Subfamily Ptp69D 285-372 1.3e-27 91.8 In-house 27-113 (307) alignment 
Range on Protein: 285-372
Range on HMM: 27-113/307.0
EFRRACKLgVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE
|...  .      . .... . |. |||  .| .|||. |||....|.| ||||||||| ||. |. .|| |.|. .|| ||||||.|
eyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiae
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 287-534 5.6e-56 184.8 In-house 31-292 (297) alignment 
Range on Protein: 287-534
Range on HMM: 31-292/297.0
RRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRknMYIATQGPLPNTIADFWRMIWE--------------
.. | .  | . || |.   | .|.|   |||.|.. |||. .  .  |||.||||. |..    .|.|| | ..|.||||.|...              
eflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddne

---MCAQYWPLEIDETeeQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPE-----SGIDLMRLVNKSHLHQKEQgpkPIVV
    ||.||. .   |   ||.||.|    .|   |  |..|... . |  | ..||.|  ||.  |..     | ..|.  |.|.. ...|    |..|
rdkkcaryWsdkgvtt..fGdvsvvlls.vsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg...Pllv

HCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEYQ
||.|| |||||.....  ......|  .|.|..|. |||.||..||   |.|| | |..|.|  . |. |
hclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 291-528 2.4e-56 185.9 In-house 13-270 (274) alignment 
Range on Protein: 291-528
Range on HMM: 13-270/274.0
KLGVNGtDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEE-FSDYINASFITGYQRK-NMYIATQGPLPNTIADFWRMIWE----------------
.| .|  ||   ..  .. |||   ||| ..  | ||.  .|.  |.|||| .| ||... ..|.|||||||||.|||||||..                
elPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkean

--MCAQYWPLEIDE--TEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMkdIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPK--PIVVHC
   ||.|.| ..|   .|. ||.... ..   | .|..|| . .....    |..  | .  ||.  .|..   |..||.. .  ..|.  |  |.||||
eqkCavyfPdaedyeiserygdveikvek.iverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhC

SAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
||| ||||.||| .. . ...||...||...|  ||..|  |||   |... . |...||..
saGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 293-528 1.6e-56 186.5 In-house 29-278 (515) alignment 
Range on Protein: 293-528
Range on HMM: 29-278/515.0
GVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MC
| |   || |. . |  ||| . |||.|.. |||| .  .  |||.|||.| ...  . |||.|||.. .. ||||....                   |
gpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikc

AQYWPLEIDETEEQGDISVTLVEeSEEDDDFTVRDIEISHAhmKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkEQGPKPIVVHCSAGSGRTG
..|||    .. . | |.| ||   | . . . | ... .   .|.| . |.|| .||. |||.    |..|. .    . .|   |...||||| ||||
gkyWPdkpgdsvkfGsikvelvs.leactggikrkltvlkg..ddsrtvtqfhfteWPdkGvpkhtssllklikevkadh.gqythpliihcsaGvGrtG

VFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
|.|...  ......  |.|||..|. .||.||..||   |. | | |. |.|  
vvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllw
subfamily_PTPN9_pd Subfamily PTPN9 294-528 8.7e-66 216.9 In-house 30-292 (297) alignment 
Range on Protein: 294-528
Range on HMM: 30-292/297.0
VNGTDQTfANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM------------------CA
|.|| .. ...  |  |||   .| .|.  |.|... ..| ||||||.|. ||..|. .|||||||..|. |||||.||                   |.
veGtfla.sklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcg

QYWPLEIDETEEQGDISVTLVEEsEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQ---------KEQGP---KPIV
|||||| ....| ||.||. ||  || .|..|| .||.... ...||.  . | .||. |||.|. .|. ...|   .|         ...|.    |||
qyWpleeessaefgdlsvsnvev.eeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPiv

VHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
|||||| |||| ||.|.. .||.||....||..||. ||.|| ...|   |..||| |..||  |
vhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 294-529 3.5e-59 195.6 In-house 35-291 (325) alignment 
Range on Protein: 294-529
Range on HMM: 35-291/325.0
VNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMI--WE---------------MCAQ
..|  .. |   .||.|||   ....||. | || .  .  |||||||..  ...|....|.| ||..|| |.||..  |.                ||.
ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcav

YWPLEIDETEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPE---SGIDLMRLVNKSHLH--QKEQGPKPIVVHCSAGSG
||| |. .. . | . | |.   ||  |.  | ...  ..  . | ..|.....|...||..   . | ...||.. .     . ..  ||.|||||| |
ywpkemgksktfGglevklrt.ieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvG

RTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
||||||.|  .. .. ||| .|.|. |. ||..|| ||.   |. ..| |.||..   
rtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 294-357 2.4e-11 37.7 In-house 35-95 (95) alignment 
Range on Protein: 294-357
Range on HMM: 35-95/95.0
VNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLerlIGEEFSDYINASFITGYQRKNMYIATQG
  |.  |    . |  |||.  |.|.|   | |        |||||| |. || ||| |||.||
tsgapytvgsseanipknrflnifpydatrvvl...ttkrdsdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 296-530 3.9e-55 181.8 In-house 35-287 (290) alignment 
Range on Protein: 296-530
Range on HMM: 35-287/290.0
GTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEF--SDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCA
    | ..  .|| .||  .|.. | | . | .. |..    .||||..| ||. |. |||||||..||..|||..||.                   | 
ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCq

QYWPLEidETEEQGDISVTLVEESEEDdDFTVRDIEISHAHM-KDIRKIRQYHFRGWPEVG-VPESGIDLMRLvNKSHLHQKEQGPKPIVVHCSAGSGRT
|||| .  .|.. | .|..|..|.. . ... | .|. . .  .. ... ||..  |.. | |..    |. . ..    |. .| ..||||||.. ||.
qYWpds..dtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi.eemyktqrkrgntsivvHCSdtvgrs

GVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQS
.||.|... . ... |  ||||| .. .|.|.| .||   |... .. ...||.. .
avfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_PTPN3_pd Subfamily PTPN3 296-528 2.3e-50 166.1 In-house 30-277 (280) alignment 
Range on Protein: 296-528
Range on HMM: 30-277/280.0
GTDQTFANIDQNKDKNRIGHILPFDKNVVKLERligEEFsDYINASFI----TGYQRKNMYIATQGPLPNTIADFWRMIWE------------------M
| . . |.  .| .|||   |||.|.  |||.    .|  |||||...     . .  | ||||||||..| .|||.|.||                   
glaisaarkpenlsknryrdilpydatrvklke...set.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CAQYWPLeIDETEEQGDISVTLVEEsEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHlHQKEQGPKPIVVHCSAGSGRT
| ||||   ... | |..||.. .| .|.  . .|.. ..... |. ||| |  .  ||. |||..  |....|.. . ....   .|.||||||| |||
ChqyWPe.tedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervr.klrsgkeePvvvhCsaGigrt

GVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
||.|.|.. .. .|..  . . . || .|.||  .||  .|.||   |...  ||
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
0045098 (Phosphotyrosine protein) phosphatases II 297-527 9e-67 220.7 In-house 23-273 (278) alignment 
Range on Protein: 297-527
Range on HMM: 23-273/278.0
TDQTFANIDQNKDKNRIGHILPFDKNVVKlerligeefsDYINASFITGYqrKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYW
 . |.|.   |.||||. .|||.| . ||          ||||||.|.||  .. .||||||||.|.||||||.||                   |||||
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PlEiDETEEQGDISVTLVEESEEdDDFTVRDIEISHA----HMKDIRKIRQYHFRGWPEVGVPESG--IDLMRLVNKSHLHQK------------EQGPK
| | ..... ||..|||..|..  ||.|.|.... .     .    |.....|. .||. |||..     . .|..  . ..|            .....
p.e.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PIVVHCSAGSGRTGVFIALNVLMSRMeeESMIDVFQTVRGLRQQRPH-MVQDLAQFKFCYSAMVEYLE
|..|||||| ||||...|.  .....  |. .|....|. ||.|||. .|| | |..|.| ...|.|.
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN6_pd Subfamily PTPN6 297-531 3.6e-61 201.8 In-house 44-302 (306) alignment 
Range on Protein: 297-531
Range on HMM: 44-302/306.0
TDQTFANIDQNKDKNRIGHILPFDKNVVKLErLIGEEFSDYINASFITGYQR--KNMYIATQGPLPNTIADFWRMIW------------------EMCAQ
 ... ..  .|| |||.  |||||...|.|.   .   ||||||..|.. ..  .. |||||| |..|..|||||.|                  |.||.
lsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCar

YWPLEIDETEeQGDISVTLVEEsEEDDDFTVRDIEISH-AHMKDIRKIRQYHFRGWPEVGVPESGI---DLMRLVNKSHLHQKEQGPKPIVVHCSAGSGR
||| | ...|  |.|||| |.| .. .|...|.. .|.  . |. |...||||. ||. |||..     |... ||. . . .|. . ||||||||| ||
YWPdeeekee.yGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGR

TGVFIALNVLMSRMEEE---SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQST
|| || ...|.. .|..     ||. ..|. .|.||  .||  .|.|| | |. .|.|....
tGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 297-526 4.8e-47 155.2 In-house 35-236 (392) alignment 
Range on Protein: 297-526
Range on HMM: 35-236/392.0
TDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEMCAQYWPLEIDEteEQGDisvtlv
 .|| |. . |. ||| . |||.|.. |||| .     |||.|||.| ... .. |||.||| . .. |||||...  .    .  .   ..||      
ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtkl..kegd......

eeseedddftvrdieishaHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLhQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQ
                   . .| | . |.||  ||. .||.    |...... .  .  |  .|...||||| ||||| |... .... ..  |.|||.
...................kgddartvaqfhftewPdkdvpkhtssllkfikevka.dfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfn

TVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
 |  .|..||.|||   |. | | |..| |
fvtnirrkrpymvqtkeqyafiygavledl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 298-529 8.3e-57 187.4 In-house 35-280 (315) alignment 
Range on Protein: 298-529
Range on HMM: 35-280/315.0
DQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWP
 |. |  ..|  ||| . |||.|.. |||| .  .  |||||||.| ...  . |||.||||. .. |||||...                   |.||||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

LEIDETEEQGDISVTLVEEsEEDDDFTVRDIeiSHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHqKEQGPKPIVVHCSAGSGRTGVFIAL
 .  .. | | |.|.|..  | | | ..| .     . .. |.. |..|..||. ||..    |..|. .     ...   ...|||||| |||||.|..
drkadsvefGsikvellsl.eadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisi

NVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
.  ..........|||..|. ||..||..||   .. | | |. |.|  .
devvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 298-526 8.7e-24 79.0 In-house 26-270 (285) alignment 
Range on Protein: 298-526
Range on HMM: 26-270/285.0
DQTFANIDQNKDKNRIGHILPFDKNVVKLErligEEFSDYINASFITGY-QRKNMYIATQGPLPNTIADFWRMIW------------------EMCAQYW
. |..  . | | ||   .   ..  | |.    .   ||| ||..    . .. ||.||||||.|..|||.||.                  | || |.
nctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PLEIDETEEQGDISVTLVEESEEDDDFTVRDI-EISHAHMKD--IRKIRQYHFRGWPEVGVPESGIDLMRLVNksHLHQKEQGPKPIVVHCSAGSGRTGV
| .. |  . |   .|| |  ||    |. .   .  .         . . .   ||.   ||    .. | .   ... .   |||.|||||| |||  
peklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielyk..wvkkvnpkekpicvhcsagvgrtat

FIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|. ..    |. |.  |.... || .|  | . ||   || | |  ..||.
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 298-525 4.9e-23 76.2 In-house 43-289 (310) alignment 
Range on Protein: 298-525
Range on HMM: 43-289/310.0
DQTFANIDQNKDKNRIGHILPFDKNVVKLErLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWP
  |.    ..  |||   ..  |.  |||. .    . ||| | ..     .. .| .||||  || ||||||..                   |  |||
sltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp

lEIDETEEQGDISVTLVEESEEDDDFT------VR-D--IEISHAHMKDIRkIRQYHFRGWPEVGVPESGIdlmRLVNKSHLHQKEQGPkpIVVHCSAGS
  .  ||  | | || . || |. .        |  .  ..   | .|..| .   ..  ||. |||.        | .  | |  .||   ||||||| 
.slgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelr.vslikwpnwpdrgvpdekc...htvpqrllaqvrhgp..cvvhcsagk

GRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
.|..| .||.. . ....   .|. . .  |...|   .|   |. .    .. .
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
0040439 (Phosphotyrosine protein) phosphatases II 299-526 1.7e-71 236.0 In-house 3-246 (249) alignment 
Range on Protein: 299-526
Range on HMM: 3-246/249.0
QTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPL
 ..|.   ||||||. .|||.| . |||. | | . |||||||.|.||..|. .||||||||.|..|||||.||                   |||||||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

eiDETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQ-GPKPIVVHCSAGSGRTGVFIAL
  ... | ||..|||... .  ||.||| .|...   .. |....... .||. |||.|  ||...... . ...|   ..|..|||||| ||||.|||.
..ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

NVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
  .....|.|  .|....|. ||.|||..|| . |..|.| |. |.|
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN1_pd Subfamily PTPN1 299-524 1.8e-42 140.0 In-house 24-269 (290) alignment 
Range on Protein: 299-524
Range on HMM: 24-269/290.0
QTFANIDQNKDKNRIGHILPFDKNVVKLERliGEEfsDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPL
.. |. ..|...||   . |.|.  .||||  ..   ||||||..   . |  || ||||||||.. ||.|.||                   |||||| 
treaklpenrnlnryrdvspydhsrikler..adn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

EIDETE---EQGDISVTLVEEsEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRL---VNKSHLHQKEQGPkpIVVHCSAGSGRTG
. .| |   |.  ..|.|..| |. . .||| .|.   . .. |.| ..|.  ||. |||||   ....   | .|   ....||   |.||||| ||.|
geeekellledtklkvklise.erksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGp..avihcsaGiGrsG

VFIALNVLMSRMEE---ESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
 |. .. .. ..|.    | .|. ...  ||..|  ..|   |..| | |..|
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 299-527 1.2e-20 68.8 In-house 35-272 (288) alignment 
Range on Protein: 299-527
Range on HMM: 35-272/288.0
QTFANIDQNKDKNRIGHILPFDKNVVKLErligEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPL
..  .  .|  ..|  ..   |   |||.    ..   ||.|  ..  . |.  | .| ||  ||  .|.|. |                    |.|.|.
diidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs

EIDETEEQGDIsVTLVEESEEDDDFTVRDIEISHAHMKDIRK-IRQYHFRGWPEVGVPESGIDLMRLVNKShlhqkEQGPKPIVVHCSAGSGRTGVFIAL
.. |.   | .  | | .. .| | .|.   .   .  . .. ... |.. |.. ||||. .  .||..       ..  ||||||.|||.|||| .|  
klGekarigrl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlili

NVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
 . .  .  .  . . . .  ||..| . .|   |. . .  . |.| 
lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_egg_pd Subfamily egg 299-524 1.8e-15 51.4 In-house 32-268 (307) alignment 
Range on Protein: 299-524
Range on HMM: 32-268/307.0
QTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIW----------------EMCAQYWPLEI
 | |  | |..| |  ..   |   ||||   |    |.| |  . |    | .| .| || ||  |||||..                | |  |||   
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkae

DETEEQ--GDISVTLVE-ESEEDDDFTVRDIEISHAHmKDIRKIRQYHfRGWPEVGVPESGIDLMRLVnkshlhqkEQGPKPIVVHCSAGSGRTGVFIAL
...     | . .. .. .|. |  |.|  . .  .. .. | .  .    . ...   | . ..|..         .  ||.||..  |  ......|.
sdslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwq.gdvnnssdvysplrvlrkl........rnlskpvvvqdilGvskaatlvai

NVLMSRMEEE--SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
.. .  .         | ..|  ||..|.  |.   .. | |  .. 
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 299-372 5.8e-10 33.2 In-house 26-98 (332) alignment 
Range on Protein: 299-372
Range on HMM: 26-98/332.0
QTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEfsDYINASFITGYQRKNMYIATQGPLPN-TIADFWRMIWE
.|. .. .| | ||| |.  ||.. |.|    |..  |. |||.. || .|. || .| |. . |   ||||. |
ntydkflnnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvse
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 299-345 2.6e-06 21.0 In-house 39-85 (440) alignment 
Range on Protein: 299-345
Range on HMM: 39-85/440.0
QTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITG
   |.. .|| |||   || .|.. | || . |   |||||||.|.|
sdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_PTPRD_pd Subfamily PTPRD 300-534 2.6e-87 288.8 In-house 41-289 (564) alignment 
Range on Protein: 300-534
Range on HMM: 41-289/564.0
TFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLE
. || ..|| |||  .|...|.. |.|... |.| ||||||||| ||.... ||||||||..||.|||||.||                   |..||| .
eaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek

iDeTEEQGDISVTLVEEsEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkEQGPKPIVVHCSAGSGRTGVFIALNV
 . ||. |.. |||.|| ||  |...|........ .. |..||.||  ||. |||||. .|..|..|.. .. |.. .||||||||| ||||.||....
.g.tetygeltVtleee.eeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivida

LMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEYQ
.. |..|| ..|..|.|. ||.||..|||   |. |...|..|.|. ..|| .
mlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteve
0037934 (Phosphotyrosine protein) phosphatases II 300-526 8.2e-60 197.7 In-house 3-242 (243) alignment 
Range on Protein: 300-526
Range on HMM: 3-242/243.0
TFANIDQNKDKNRIGHILPFDKNVVKLerligEEfSDYINASFITGYQRknmYIATQGPLPNTIAD----FWRMIWE------------------MCAQY
..|.. .|..|||  .|||.| . |||     |  ||||||..|... |   .||||||||.|..|    ||||.||                   ||||
siallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPleiDETeEQGDISVTLVEESEEDDdFTVRDIEISHAH-MKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKE-------QGPKPIVVHCSAG
||   .|. . ||..|||..|.. || .||| .....    .  | ...||. .||. |||.|  ||...... . ...|        . .|..||||||
wp...gev.tygdftvtllseehldd.ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

SGRTGVFIALNVLMSRMeeeSmIDVFQTVRGLRQQRPH-MVQDLAQFKFCYSAMVEYL
 ||||..||. ......   . .|....|. ||.|||. .|| . |..|.| |. |.|
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 300-526 7.8e-43 141.5 In-house 41-279 (439) alignment 
Range on Protein: 300-526
Range on HMM: 41-279/439.0
TFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM-------CA------QYWPLEidETE
..|  . .. |||   . .||   | |. . |   | |||| .| ||  ...|||||||  .|  ||||...|         .      .||| .  .  
slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesykywpsd..aev

EQGDISVTlVEESEEDDDFTVRDIEISH--AHMKDIRKIRQYHFRGWPEVGVPESG---IDLMRLVNKSHlHQKEQGpkPIVVHCSAGSGRTGVFIALNV
  |||.|  |.   |  ....| . .     . .  | . |.|.  ||.  ||      .|..| .| .   ..| |  |.||||||| ||||  |||..
cygdiavr.vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan.dkeeyg..pvvvhcsagvGrtGtiialdi

LMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
 . ..  |  .|.   |. ||.|| .|||.|.|. | | |..| .
aleqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
0049772 (Phosphotyrosine protein) phosphatases II 300-532 1.3e-38 128.9 In-house 39-286 (314) alignment 
Range on Protein: 300-532
Range on HMM: 39-286/314.0
TFANIDQNKDKNRIGHILPFDkNVVKLERLIGEEfSDYINASFITGYqrkNMYIATQGPLPNTIADF----------WRMI--WEMC-------------
..|..  |.||||  .|||.| | |.| .| ..  |||||||.. |.   . .|||||||..|. ||          |||.  ...              
lvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

----------------------AQYWPLEIDETEeqgdisvtlvEESEEDDDFtvrdieishahmkdIRKIRQYHFRGWPEVGVPeSGIDLMRLVNKSHL
                      ..... .... .          ||  ....|               | . .|.   .|  ..| .  |. ....  . 
delsrLdaAlgKtpllildgngneptaadlellk..........eelydpelf..............erlgikylripvpDgsap.lledfdeflefiee

HqkeQGPKPIVVHCSAGSGRTGVFIALNVLMSRMeeeSMiDVFQTVRGLRQQRP-----HMVQDLAQFKFCYSAMVEYLEEQSTE
.   . ..|..|||.|| ||||.|...  ||...    . .. .... .|..||     .... | |. |.. |. |||. . ..
a...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
0042113 (Phosphotyrosine protein) phosphatases II 301-527 5e-69 227.7 In-house 3-244 (245) alignment 
Range on Protein: 301-527
Range on HMM: 3-244/245.0
FANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLei
.|.   ||||||. .|||.| . |||    |...|||||||...||.... .||||||||.|..|||||.||                   |||||||  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

DETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVL
.|. . ||..|||..|   .||.||| .|...   .  |....||. .||. |||..  .| ....  . ...| ...|..|||||| ||||.|||.  .
gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

MSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
....|.|  ......|. ||.|||..|| . |..|.| |. |.|.
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 301-531 9.6e-54 177.3 In-house 41-283 (287) alignment 
Range on Protein: 301-531
Range on HMM: 41-283/287.0
FANIDQNKDKNRIGHILPFDKNVVKLErligEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLEi
 .   |||||||. .||. |.. | |.    .|  |||||.|| ||. |. .|....|. ||. .||..|..                  .| |||| | 
hniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpee.

dETEEQGDISVTLVEESeEDDDFTVRDIEISHAH-MKDIRKIRQYHFRGWPEVG-VPESGIDLMRLvNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALN
 ..   |. ...|..|    .....|..|. . .  .| ....||..  |.. | |.|    |. . ..    |. .|  .||||||.. ||...|.| .
.ksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi.eemyktqrkrgntsivvhCsdtvGrsamfcaaa

VLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQST
. . . ..|  ||||| ..  |.|.|..||  .|.|| . ...|||.  .|
ttinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_PTPN13_pd Subfamily PTPN13 301-373 6.9e-19 63.2 In-house 31-100 (273) alignment 
Range on Protein: 301-373
Range on HMM: 31-100/273.0
FANIDQNKDKNRIGHILPFDKNVVKLERLIGeefsdYINASFITGYQRKN--MYIATQGPLPNTIADFWRMIWEM
 .. ..||||||  ..||.|.  |||.   |     |||||.|     |.   |||.|||||.|..|||.|.|| 
vgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweq
subfamily_PTPRK_pd Subfamily PTPRK 302-524 1.6e-63 209.5 In-house 38-275 (314) alignment 
Range on Protein: 302-524
Range on HMM: 38-275/314.0
ANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM------------------CAQYWPleiD
|. |.|..|||.|.||..|.  |.|  . |.  ||||||..| .|.| . .|.|||||..|..||||....                   | .|||   .
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP...e

ETEEQGDISVTLVEeSEEDDDFTVRDIEISH--AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEqGPKPIVVHCSAGSGRTGVFIALNV
.||  ||| |.||| .| . .. ||   ...    ...||..||..| |||. .|| |   |..|| . . .|.| .  .||||||||.||||.|||...
dtevygdikvelve.tellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidi

LMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
..  .|.|...|||..|. ||.... ||.   |.||.| ...|
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 302-528 3.8e-63 208.0 In-house 4-244 (250) alignment 
Range on Protein: 302-528
Range on HMM: 4-244/250.0
ANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE-----------------MCAQYWPleIDE
|.  |||.|||  .|...|.  | ||.  |.. ||||||||. ||. ....|||||||..|| |||||..|                  . ||||  ...
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywP..vek

TEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMS
.|. ||. |.| . .||  |.|.| . .|.|. .| | .||.||  ||. ||||     . |..| .  |.. | .|..|.|||| ||.| |||.. .. 
aekyGdvtvslls.keefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

RMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
|...| ..|||. .. ||..|||.|. |.|. |.|... ..|. 
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 302-524 6.5e-21 69.2 In-house 32-267 (281) alignment 
Range on Protein: 302-524
Range on HMM: 32-267/281.0
ANIDQNKDKNRIGHILPFDKNVVKLER-LIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIW------------------EMCAQYWPLEI
 |   |. |||   |  .|   |.|.  .  .. .||| | .|     |  || ||||  .| ||||||||                  | ||.|.| . 
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

DETEEQGDISVTLvEESEEDDDFTVRDIEISHahMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkeqgpKPIVVHCSAGSGRTGVFIALNVL
    .   .||.  |.|  .  .    ...|.    . | | .. .. ||.  ||||   ..... | . .       | |.||||| ||.| ..|... 
hcclqfdklsvsy.edstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrkirars.....tppvihcsagvgrsgtlmaveia

MSRME-EESMIDVFQTVRGLRQ-QRPHMVQDLAQFKFCYSAMVE
.  .    .. |. | |  ||   |   || | |. . .  ...
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 303-529 1.1e-48 160.6 In-house 16-267 (270) alignment 
Range on Protein: 303-529
Range on HMM: 16-267/270.0
NIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQ-RKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLEID
.. ..|  ||   |||  .  |.||.|  .. . |||| .. |.. .|. |||..||||.|. .|||||||                   |..||| | .
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

E--TEEQGDISVTLVeESEEDDDFTVRDIEIShaHMKDIRKIRQYHFRGWPEVGVPESGI------DLMRLVNKSHLHQKEQGP-KPIVVHCSAGSGRTG
|  . |.|.|.|. . ..| .. . .. ...   .  ..|..  ...  ||. |||..        .|...... . ..||.   .|..|||||| ||||
ekvkledgkikvlal.seekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

VFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
..|||.  .  .||.. .|| . .. ||..|. .||   |..| | |.||| | .
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 303-372 6.4e-29 96.0 In-house 42-111 (318) alignment 
Range on Protein: 303-372
Range on HMM: 42-111/318.0
NIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE
. . || |||   ||..|.  |||. | ||| ||||||..| ||.||. |||.|.|||.|| |||||.||
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWe
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 304-525 3.3e-59 195.4 In-house 46-278 (315) alignment 
Range on Protein: 304-525
Range on HMM: 46-278/315.0
IDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPleiDET
  .||.|||  .|...||  |.|  |  .. |||.||.|| ||..|..|||.|||..... ||||...|                  .. .|||   |. 
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp...dkk

EEQGDISVTLVEEsEEDDDFTVRDIeiSHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGpKPIVVHCSAGSGRTGVFIALNVLMSR
   | |.||...| |  ...||| .  |    ..||.. |.|.  ||..|||.. | || |. . . |....   .|||||||| |||| ||.|. .. .
viyGkitvtrkse.evnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldq

MEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
.| | .|||.. ..|.||.| .||| ..|..| |.|..| 
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 304-370 2.9e-08 27.7 In-house 51-114 (290) alignment 
Range on Protein: 304-370
Range on HMM: 51-114/290.0
IDQNK--DKNRIGHILPFDKNVVKLERliGEEfSDYINASFITGYqrKNMYIATQGPLPNTIADFWRMI
.|.|    |||   .   ||  | |.   | .  ||. | .. |   | |.| |||.| .|. |.|||.
fdkntefkknrykdvvcndktrvilkd..Gyd.GdyvhanyvkGl..kamfiltqGalkdtvidiwrmv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 305-529 1.3e-15 51.9 In-house 41-279 (312) alignment 
Range on Protein: 305-529
Range on HMM: 41-279/312.0
DQNKDKNRIGHILPFDKNVVKLerlIGEEfSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEMCAQYWPLEIDETEEQGDIS----VTLVEE--
 . || ||   |  .|.    |    |.|   || | |.    . . ...||||| ||.. ||..   . .    | .   |.  . .      .|    
lkfkdlnrypniqcwdrgrftl...agde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

SE-----------------EDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKShlhQKEQgpKPIVVHCSAGSGRTGVFIALNV
 |                   |  | | . .      .  |. .| .  ||. |.|.|    .||.      .|..  ||.. ||||| |||| .. .. 
ledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav...kkdk..kpviahcsagvgrtgtlalies

LMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
... .      .| ..   ||..|   |. ..|. ..  ...|.|  .
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 305-373 2.2e-12 41.1 In-house 94-160 (244) alignment 
Range on Protein: 305-373
Range on HMM: 94-160/244.0
DQNKDKNRIGHILPFDKNVVKLERliGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM
 .|  ||| |  |||| | | | .  |     ||||||.    |   || || || .|  |||.|. | 
pnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmler
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 305-371 1.2e-09 32.4 In-house 46-109 (305) alignment 
Range on Protein: 305-371
Range on HMM: 46-109/305.0
DQNKDKNRIGHILPFDKNVVKLErliGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIW
 |...|||   .  .|.| ||||   |    .|| | ...     . .| || || .| |||| | .
aqeagknrykdvgcldnnrvkle...gpwpheyihanyvstptnpkrfictqaplektcadfwymcl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 305-372 9.7e-08 26.0 In-house 45-105 (303) alignment 
Range on Protein: 305-372
Range on HMM: 45-105/303.0
DQNKDKNRIGHILPFDKNVVKLERligeefSDYINASFITGYQRKNmYIATQGPLPNTIADFWRMIWE
 .| ||||.  .. .|.  |||        | || ||..    .|.  | || ||. | ||||.|| |
vknmdknrfvdvicldhskvklsd......ssyihasyleldsskk.ailtqlplshtaadfwqmiie
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 306-524 1.7e-39 130.4 In-house 6-238 (239) alignment 
Range on Protein: 306-524
Range on HMM: 6-238/239.0
QNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQR-KNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPleiDETE
 || |||   |. .|.. | ||.|  . .|||||||..  |.   . |||||| .  .  |||||.|.                   | ||||   | | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dsts

EQGDISVTLVeESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHlHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRM
.  .. |||  ..|   |. .| . .|.    . | . ||||  ||. |||.    .. |  |   ..   | .| |.||||| |||| |. .. .. . 
kycnlrvtlr.ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqa

EEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
...  .|.|. |. .|..||||||   |. | . |..|
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 306-524 2e-39 130.1 In-house 7-239 (239) alignment 
Range on Protein: 306-524
Range on HMM: 7-239/239.0
QNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQR-KNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPleiDETE
 || |||   |. .|.. | ||.|  . .|||||||..  |.   . |||||| .  .  |||||.|.                   | ||||   | | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dsts

EQGDISVTLVeESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHlHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRM
.  .. |||  ..|   |. .| . .|.    . | . ||||  ||. |||.    .. |  |   ..   | .| |.||||| |||| |. .. .. . 
kycnlrvtlr.ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqa

EEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
...  .|.|. |. .|..||||||   |. | . |..|
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 306-523 4.4e-39 129.1 In-house 2-236 (237) alignment 
Range on Protein: 306-523
Range on HMM: 2-236/237.0
QNKDKNRIGHILPFDKNVVKLERLIGEefSDYINASFITGYQR-KNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPlEIDETE
.|| ||| | |  .|.. | |.   ..  ||||||... |..   . |||.|||| ..  |||.|.|.                   | .||| . |. .
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpa

EQGDISVTLVEeSEEDDDFTVRDIEISH-AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKShLHQKEQ--GPKPIVVHCSAGSGRTGVFIALNVLM
  | ..|.|    ||  |.||| . .|.  ..|..| | ||.|  ||. |||.    |.|.  .  ... .      | ..||||| ||||.|. .. ..
aygvltvslkk.keefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkni.inrsphvsesgpwiihcsagvgrtgiflvidaml

SRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMV
 . .|. ..|... |  . ..||...|   |. | . ...
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 306-372 1.3e-12 42.2 In-house 30-98 (297) alignment 
Range on Protein: 306-372
Range on HMM: 30-98/297.0
QN--KDKNRIGHILPFDKNVVKLERLIGEefSDYINASFITGYQR--KNMYIATQGPLPNTIADFWRMIWE
.|    |||  .|| .|.. ||| | | |  .||||| ...  .   .  || .|||| .|. |||....|
rnsslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvae
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 306-371 1.9e-11 38.3 In-house 46-125 (350) alignment 
Range on Protein: 306-371
Range on HMM: 46-125/350.0
QNKDKNRIGHILPFDKNVVKLER--------LIGEEFSDYINASFITGY-----QRKNM-YIATQGPLPNTIADFWRMIW
.   |||   |||.... |||..            . .|||||...        .  .  |||||.|||.|. ||...| 
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvil
Y_phosphatase Protein-tyrosine phosphatase 307-524 4.5e-68 224.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 307-524
Range on HMM: 1-235/235.0
NKDKNRIGHILPFDKNVVKLerlIGEEF-SDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLEIDETEE
||.|||  .|||.||. |||    |.|  ||||||....||..|...|||||||..||.|||||.|.                   |||||| | .|...
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

QGDISVTLV-EESEEDDDFTVRDIEISHAHMKD-IRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkEQGPKPIVVHCSAGSGRTGVFIALNVLMSR
 |||.|.|. .|.|.....|.|..|...   ..  |...|.|. .||. |||||  .|..|..| . .. |.  .|.|||||||.||||.|.||..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

MEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
.|.|. .||.|.|. ||.|||.|||.|.|..|.| |..|
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 307-524 4.5e-68 224.5 In-house 1-235 (235) alignment 
Range on Protein: 307-524
Range on HMM: 1-235/235.0
NKDKNRIGHILPFDKNVVKLerlIGEEF-SDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLEIDETEE
||.|||  .|||.||. |||    |.|  ||||||....||..|...|||||||..||.|||||.|.                   |||||| | .|...
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

QGDISVTLV-EESEEDDDFTVRDIEISHAHMKD-IRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkEQGPKPIVVHCSAGSGRTGVFIALNVLMSR
 |||.|.|. .|.|.....|.|..|...   ..  |...|.|. .||. |||||  .|..|..| . .. |.  .|.|||||||.||||.|.||..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

MEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
.|.|. .||.|.|. ||.|||.|||.|.|..|.| |..|
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 307-529 1.5e-41 137.4 In-house 1-174 (182) alignment 
Range on Protein: 307-529
Range on HMM: 1-174/182.0
NKDKNRIGHILPFDKNVvklerligeeFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM---------CAQYWPleideteeqgdisvtlve
|.||||  .|||.| .           ..|||||... |... . .|||||||..|.|||.||..|.         . .|||                  
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywp..................

eseedD-DftvrdieishahmkdIRKIRQYHFRGWPEVGVPEsgidLMRLVNKSH---LhqkeqGPKPIVVHCSAGSGRTGVFIALNVLMSRmeeesMID
     .                  | . ||.. .||  |||.    |  |..  .          ..|..|||||| ||||...|. .....      ..
.....ell...............erlgiqylylpwpDhgvpd....ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvs

VFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
....|. .|..||.||. . |. |.. |. |.|. .
leeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_CG42327_pd Subfamily CG42327 307-372 1.1e-12 42.3 In-house 28-94 (319) alignment 
Range on Protein: 307-372
Range on HMM: 28-94/319.0
NKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQR-KNMYIATQGPLPNTIADFWRMIWE
 |||.|. ...|. .  | |.|   .. . |..||.. ||.  .| |||.| .| .. .||||..||
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvwe
0044763 (Phosphotyrosine protein) phosphatases II 318-526 8.3e-28 92.6 In-house 1-171 (178) alignment 
Range on Protein: 318-526
Range on HMM: 1-171/178.0
PFDKNVVKLERLIGEEFSDYINASFITGYqrknMYIATQGPlpntiADFWRMIWEMC------------------AQYWPLEIDeteeqgdisvtlvees
|.| ..|.|. | |.| |||||||.|...    .|.....|     ||......|.                    .||| | .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

eedddftvrdieishahmkdirkiRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGpKPIVVHCSAGSGRTGVFIALNVLMSRmeeeSMiDVFQTVR
                         ||.. ..|  |||..   ....|.  . ...|.| .|..|||||| ||.|...|.  ....    .. .... ..
........................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaie

GLRQQRPhMVQDLAQFKFCYSAMVEYL
 .|..|| .|.   | ...|    ..|
lvrerRp.ivpnpgqlrqLyefelrll
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 328-432 6.5e-07 23.7 In-house 9-122 (130) alignment 
Range on Protein: 328-432
Range on HMM: 9-122/130.0
RLIgeeFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEMC-------------AQYWPLEIDETEEQGDISVTLVEEsEEDDDFTVRDIEISH
||      .||||||.   .| . |. || || .|  |||.|. |                .|||        . || ||| .  .| .      .||..
rlq...gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyeediivtltdr.defknikasnleies

AHMKDIRKIRQYHFRGWP
  ..  . .  ..   ||
dlneshqaltmfqisnwp
0046846 (Phosphotyrosine protein) phosphatases II 329-527 1e-35 118.4 In-house 6-174 (176) alignment 
Range on Protein: 329-527
Range on HMM: 6-174/176.0
LIGEEFSDYINASFITGYqrknMYIATQGPLPNTIADFWRMIWEM------------------CAQYWPLEIDETEeqgdisvtlveeseedddftvrdi
|. ....|||||..| |.    ..||||||||.|.|||..|..|.                  |..|||.. ..                          
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

eishahmkdirkirQYHFRGWPEVGVPESgIDLMRLVNKSHLHQKEQgpKPIVVHCSAGSGRTGVFIALNvlmsRMEEESMIDVFQTVRGLRQQRP-HMV
              ||.. .||. |||..  .|..|..  . ..||   .|..|||||| ||||...|.      .| |  ..|..... .|.||| ..|
..............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QDLAQFKFCYSAMVEYLE
|  .| .|.| .. ..|.
qtpeQyrflyefellllk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 330-373 9.2e-09 29.3 In-house 65-108 (347) alignment 
Range on Protein: 330-373
Range on HMM: 65-108/347.0
IGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM
  ..   ||||| |   . .. || || |||.|. |||.|.  .
raddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvt
0043147 (Phosphotyrosine protein) phosphatases II 332-519 1.4e-36 121.2 In-house 2-154 (172) alignment 
Range on Protein: 332-519
Range on HMM: 2-154/172.0
EEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEMCAQYWPLEIDEteeqgdisvtlveeseedddftvrdieiSHAHMKDIRKIRQYHFRGW
.|.|||||||.. .|   . .|||||||.||.||||||..|.  ...    ..                             .   .  | . ||.. .|
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................lydpellerlgiqylylpw

PEVGVPeSGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMsrmeeeS-MiDVFQTVRGLRQQRPHMVQDLAQFKFCY
|  ||| .   |.....  . .. ..  .|..|||||| ||||...|.  ..        . .....|. .|..||..||   | .|.|
pDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrfly
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 333-370 1.6e-06 21.7 In-house 88-127 (349) alignment 
Range on Protein: 333-370
Range on HMM: 88-127/349.0
EFSDYINASFI--TGYQRKNMYIATQGPLPNTIADFWRMI
   ||||| ..  | .. .. ||||| ||| |. ||...|
klddyinanylkltrisvekkyiatqaPlPstvddfykvi
0051429 (Phosphotyrosine protein) phosphatases II 334-528 2e-44 147.6 In-house 3-227 (272) alignment 
Range on Protein: 334-528
Range on HMM: 3-227/272.0
FSDYINASFITGYQR---KNMYIATQGPLPNTIADFWRMiWEM------------------CAQYWP----------LEIDETEEQGDISVTLVEESEED
.|.||||... || |   ........||||.|.|||||. .|.                  | .|||           . ..| ..|...|||..|.  .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DdFTVRDIEISHA-HMKDIRKIRQYHFRGWPEVGVP-ESGIDLMRLVNKshlhqkeqgPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMID-------
| ...| .....  .....|.....|...||  ||| |. ..|..|...         ..|..|||||| .|||...||  |. ....| ..|       
d.yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
 ....|. ||.|||..||. .|..|.| |..|.|..
yleeaveelraqrpgavqteeqylflyeallellrs
0051082 (Phosphotyrosine protein) phosphatases II 334-522 1e-26 88.8 In-house 2-149 (151) alignment 
Range on Protein: 334-522
Range on HMM: 2-149/151.0
FSDYINASFITGYqrknmYIATQGPLPntiaDFWRMIWE----------------MCAQYWPLEIdeteeqgdisvtlveeseedddftvrdieishahm
.|||||.|..||.     .....|||.    ||.....|                .|..|.| .                                    
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...................................

kdiRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLhqkeQGPKPIVVHCSAGSGRTGVFIALNVLMSRmeeesmIDVFQTVRGLRQQRPHMVQDLAQFKF
   ........ .||. |.|.|   .......       ....|..|||||| ||||...||  .. .      ........ .|..||..||   || |
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

CYSAM
.. |.
qlfal
0036282 (Phosphotyrosine protein) phosphatases II 335-519 9.1e-38 125.0 In-house 2-163 (174) alignment 
Range on Protein: 335-519
Range on HMM: 2-163/174.0
SDYINASFITGYQRKNMYIATQGPLPntiadFWRMIWE------------------MCAQYWPLeideteeqgdisvtlveeseedddftvrdieishAH
|||||||.. .. . . .||.||||.     ||.|..|                  .| .|||                                    .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lr

MKDIRKIRQYHFRGWPEVGVPESGIdLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEeESMIDVFQTVRGLRQQRPHMVQDLAQFK
    | . ||.. .||  |||.. | | ..|.  . ...| . .|..|||||| ||||...|.  .. ... ||..|....|| ||.|||.|||   |..
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FCY
|.|
fly
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 337-517 1.8e-23 77.7 In-house 77-272 (301) alignment 
Range on Protein: 337-517
Range on HMM: 77-272/301.0
YINASFITGYQRKNMYIATQGPLPNTIADFWRMIW------------------EMCAQYWPLEIDETEEQGDISVTLVEESE-EDDDFTVRDIEISHAHM
 | | .|    . . .|||||||.||  ||| |.                   |.|..| |..| |. . |  .......    ... . | .|.  .  
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

K-DIRKIRQYHFRGWPEVGVPESGIDLMRLVNkshLHQKEQgpKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFK
| . | .  | .  |.. |||.| ..|. |..   | .| .  |||||||||| ||.  ||. ..| ...| .  |.. .... ||..| . ||   |. 
kfatrtvthyqysewtdrgvPkshaelfdlme...lvkkse..kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly

F
.
w
0049260 (Phosphotyrosine protein) phosphatases II 342-519 1.1e-32 108.2 In-house 1-143 (152) alignment 
Range on Protein: 342-519
Range on HMM: 1-143/152.0
FITGYQRKNMYIATQGPLPNTIADFWRMIWEM------------------CAQYWpleideteeqgdisvtlveeseedddftvrdieishahmkdirki
|| || .....||||||.|||.||||||..|.                  |.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

rQYHFRGWPEVGVPESGIDLMRLVNKSHLHqKEQGPKPIVVHCSAGSGRTGVFIALNVLMsrmeeeSMIDVFQTVRGLRQQRPHMVQDLAQFKFCY
 ||..  ||  |||.. . |. |.   . . ...  .|..|||||| ||||...|.  ..        ......|. .|..||..|.   | .|.|
.qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 344-372 3.7e-06 20.5 In-house 230-258 (440) alignment 
Range on Protein: 344-372
Range on HMM: 230-258/440.0
TGYQRKNMYIATQGPLPNTIADFWRMIWE
 || .|| .|||| ||  |. ||||.. .
egyskknafiatqmpldstvldfwrlvhd
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 349-373 7.7e-06 20.2 In-house 4-28 (199) alignment 
Range on Protein: 349-373
Range on HMM: 4-28/199.0
KNMYIATQGPLPNTIADFWRMIWEM
.  ||||| || .|.||||.|.|| 
qrryiatqhplretmadfwqmvwet
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 350-373 9.1e-06 20.0 In-house 4-27 (198) alignment 
Range on Protein: 350-373
Range on HMM: 4-27/198.0
NMYIATQGPLPNTIADFWRMIWEM
  ||||| || .|.||||.|.|| 
rryiatqhplretladfwqmvwet
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 363-532 4.6e-17 56.9 In-house 59-230 (255) alignment 
Range on Protein: 363-532
Range on HMM: 59-230/255.0
IADFWRMIWEMCAQYWPLEIDETEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKShlhQKEqgpKPI
..||     | | .|.||| ||     |..||  . |  |  .  ..|    .. |  .... |...||.|   ||   ... ..      ..    |..
lcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvv...rds...ksv

VVHCSAGSGRTGVFIALNVLMS----RM--EEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL---EEQSTE
|||||.| ||.  |.  ...       .   |   .|  . .. ||..|.  ...  |. |.   .....   .|   .
vvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleak
subfamily_hpo-7_pd Subfamily hpo-7 363-527 2.5e-15 51.1 In-house 65-228 (263) alignment 
Range on Protein: 363-527
Range on HMM: 65-228/263.0
IADFWRMIWEMCAQYWPLEIDETEEQGDISVTLVEESEeddDFTVRDIEISH--AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKShlhQKEqgpK
..||     | | .|.||| ||     ...|.  .  .   |  .. .|.     . | ......| ..||.|.  ||  .. .....     ..    |
LcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkva...rns...k

PIVVHCSAGSGRTGVFIALNVLMS----RM--EEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
..|||||.| ||.  |   ...       .   .   .|  . .. ||..|.  ...  |. |    ..... 
slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
PTEN_1 370-502 1.6e-07 26.3 In-house 30-171 (196) alignment 
Range on Protein: 370-502
Range on HMM: 30-171/196.0
IWEMCAQYWPL--EIDETEEQGDISVT--LVEESEEDDDFTVRDIE-ISHAhM------KD-IRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQ
|.  .|   ||  ||||.  .| ..    .... .||. ..| . . ...  .      .. ...  .|. ....  |.|     .  ...  .  .. .
iamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeel.sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdp

GPKPIVVHCSAGSGRTGVFIALnVLMSRMEeESMIDVFQTVRGLR
  . ..||| || ||.|. .|   ||...   .. . .. ||  |
ngnvVlVHCkaGlgRsGtvvaa.yLmykgk.ltadeAlelvrekR
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 372-528 6.3e-13 43.5 In-house 111-261 (290) alignment 
Range on Protein: 372-528
Range on HMM: 111-261/290.0
EMCAQYWPLEIDETEEQGDISVTLvEESEEDDDFTVRDIEISHAHMKDIrKIRQYHFRGWPEVGVPESGIDLMRLVNKSHlhQKEqgpKPIVVHCSAGSG
. ||.| | ...|    ....|    . |..||. .| ... .   ..  ..  . ..|| .. |.|. . |. |..| .  ...    |..|||  |  
faCakYvpesvgeelkfkgltvkC.kskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvk..ask...tpvivHcvdGiS

RTGVFIALNVLMSRME-EESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
|  .. |... .  .   .. . . . .  ||.|| .....  .. |   ..| .. |
rsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaie
subfamily_CG42327_pd Subfamily CG42327 372-450 8.7e-08 26.2 In-house 112-190 (319) alignment 
Range on Protein: 372-450
Range on HMM: 112-190/319.0
EMCAQYWPLE--IDETEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFrGWPEVGVPESGIDLMRLVNKS
..||.|.| .   |.|.  ||| ||| .  | .| . .  . . . . .  |..  | .  |.| .|| .   |. .. . 
kvcaeylPtketldntslyGdilvtlkg.revkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev
subfamily_PTPRA_pd Subfamily PTPRA 373-532 1.9e-49 163.4 In-house 142-301 (330) alignment 
Range on Protein: 373-532
Range on HMM: 142-301/330.0
MCAQYWPLEidETEEQGDISVTlVEESEEDDDFTVRDIEIS----HAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPkPIVVHCSA
 |||||| |   .   |.| |. ||....  |.|||.. .     ... |. | .||.||..||.||||  .| ...|..| .  .. ..  ||||||||
kcaqywPde..GlvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsa

GSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTE
| |||| ||.|. .. |.. | ..|||..|. ||.|||.||| . |..|.| .. ||     ||
GvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdte
subfamily_Ptp69D_pd Subfamily Ptp69D 373-531 2.3e-47 156.6 In-house 132-291 (307) alignment 
Range on Protein: 373-531
Range on HMM: 132-291/307.0
MCAQYWPLEidETEEQGDISVTLVEESEeDDDFTVRDIEISHAH-----MKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQgPKPIVVHCS
 ||.||| |  .. . ||| |.||.|..  .|.. |....|. .     ..| ||. |||. ||... |||.   |..|... . ..| .   |||||||
kcakYWpie..devqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCs

AGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQST
||.||.|.|.||..|. ....|  .|.|.||..||.||. .|| |.|..|.| |...| .   |
aGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 373-525 7.6e-22 72.3 In-house 135-282 (290) alignment 
Range on Protein: 373-525
Range on HMM: 135-282/290.0
MCAQYWPLEIDETEEQGDISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKshlhqKEQGPKPIVVHCSAGSGR
 |.||.| .  |.   |.|.|.  ||...|..   . . . . .     |.. .. . ||.  |. | . |.|..         . . |.||||||| ||
kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlri.....lrkasGpvvvhcsaGiGr

TGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
|| |.|..| .  . .   .|. ..|| ||. |   ||   |.     .....
tGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 373-446 2.5e-08 28.1 In-house 117-189 (297) alignment 
Range on Protein: 373-446
Range on HMM: 117-189/297.0
MCAQYWPLEIDETEEQGDISVTLVEESEEDdDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRL
 || |||   .|  . ||. |  . .  ..   .|   |.   . .. |..|   | .||. |||    || |.
kcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 374-533 1.2e-51 170.7 In-house 131-287 (318) alignment 
Range on Protein: 374-533
Range on HMM: 131-287/318.0
CAQYWPLeiDETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRT
...|||   ..... |.. |.| || |  .|...| ..... .... |..||||.  ||. |||||| .|. || ...  |...| .||||||||| |||
vhryWPs..kgsrsygklvvelkeeve.lsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrt

GVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEY
|||||...|. |...|...||||||. ||.||. |||   |..|.| ...|.|.   || 
GvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_PTPN13_pd Subfamily PTPN13 374-527 1.8e-36 120.9 In-house 119-270 (273) alignment 
Range on Protein: 374-527
Range on HMM: 119-270/273.0
CAQYWPLEIDETEEQGD-ISVTLVEESeEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGpkPIVVHCSAGSGR
| .||| . ...    . . |.|..   . |.|.||...... . .. |.. . .|  ||. ||| |  .|...| .    |...|  ||||||||| ||
chrywPesknkklkvsnrlevellkvq.kldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdag..PivvhcsaGiGr

TGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
.|..|...|..  .| .  .|| ..|| ||.||  .||   |. |.| |..| |.
sGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN14_pd Subfamily PTPN14 374-528 3.3e-27 90.3 In-house 135-298 (300) alignment 
Range on Protein: 374-528
Range on HMM: 135-298/300.0
CAQYWPLEI--DETEEQGDISVTlVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPES---GIDLMRLVNKSHLHQKEQG-----PKPIV
. .|.| .    .| | |   ||  . ||. | .. . ... |   |. |..    .  ||. ||||     .. .. |.    . ...        |..
sfkyfPkleskkktvefgkfkvt.tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
|||||| ||||| |  ..|.. .| .  ||. .... ||.|| ..|| |||.|| |.....||..
vhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 374-517 6e-12 39.6 In-house 133-279 (302) alignment 
Range on Protein: 374-517
Range on HMM: 133-279/302.0
CAQYWPLEIDETEEQGDISVTLVEESE------EDDDFTVRDIEISHAHMKD--IRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkeqgpKPIVVH
||.|.  ..... . |  .|. |.  .      .  .|..  .||   ..|.   . .   .| .||. | |.     . ...    ..     | ..||
caeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesyk.....knvlvh

CSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKF
|||| |||| ..|.   .    .. . |. . |  .|| |   |||  |  .
csaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
0048076 (Phosphotyrosine protein) phosphatases II 376-524 4.9e-22 73.6 In-house 1-141 (145) alignment 
Range on Protein: 376-524
Range on HMM: 1-141/145.0
QYWPLEIDETEEQGDISVTL-VEESEEDDDFTVRDIeiSHAHM--KdiRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQgpKPIVVHCSAGSGR
.||| ||..    |.. ..| .|. .. .  || ..  ..     .  |.. ||.. .||  |||..  .|.....  . ..||   .|..|||||| ||
pywpseilpglylgslptaldlellkdlgittvlnl..tselelle..rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgR

TGVFIALNVLMSrmeeESmIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
||...|. ....    .. ........ .|.|||..|.   |..|.| .  |
tgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefele
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 376-520 1.6e-16 55.1 In-house 49-198 (199) alignment 
Range on Protein: 376-520
Range on HMM: 49-198/199.0
QYWPLEIDETEEQGDISVTLVEESeEDDDFTVRDIEISH--AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQG--PKPIVVHCSAGSG
 |||     | . | .|||    .    |.|.  . ..   .     |.| .| |  | |   |.  . .  .|    . .| .     |..|||| | |
fywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqg

RTGVFIALNVLMSRMEE--ESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYS
 ||||.||.. .   ||   |..|.|.  . ||| |  ..  | ...| | 
ftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 376-520 1.6e-16 55.1 In-house 48-197 (198) alignment 
Range on Protein: 376-520
Range on HMM: 48-197/198.0
QYWPLEIDETEEQGDISVTLVEESeEDDDFTVRDIEISH--AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQG--PKPIVVHCSAGSG
 |||     | . | .|||    .    |.|.  . ..   .     |.| .| |  | |   |.  . .  .|    . .| .     |..|||| | |
fywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqg

RTGVFIALNVLMSRMEE--ESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYS
 ||||.||.. .   ||   |..|.|.  . ||| |  ..  | ...| | 
ftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_ptpA1_pd Subfamily ptpA1 386-487 3.2e-11 37.6 In-house 152-257 (418) alignment 
Range on Protein: 386-487
Range on HMM: 152-257/418.0
EEQGDISVTLVEESEED-DDFTVRDIEIshAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQG-----PKPIVVHCSAGSGRTGVFIAL
|  |  || |||  ..   .   |.| .  .   . | | ||.. |||.  .|.    . .|.     .|..         ||.|||||| |||| | . 
evfgtysvelveviqdpereiitrnirl..tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfcta

NVLMSRME
 ..| ...
vimmkkld
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 391-526 1.8e-10 35.0 In-house 143-279 (303) alignment 
Range on Protein: 391-526
Range on HMM: 143-279/303.0
ISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIrqYHFRGWPEVGVPESGI-DLMRLV-NKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNV-LMSRME
| |    . |  | .... . .|  . | . ..  .|.. ||   .|  |   ... . .   . .|    .| |    .| ||.| |  ..   .|  .
irvgefkrvelgdgwvlkvlsvsngdyksflhv..hhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhs

EESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|.. .|. . .  .|. | | ||.|.|| . |. . |..
eqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
0048179 (Phosphotyrosine protein) phosphatases II 407-520 5.6e-21 70.2 In-house 33-139 (144) alignment 
Range on Protein: 407-520
Range on HMM: 33-139/144.0
VRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKeQGpKPIVVHCSAGSGRTGVFIALNVLMsrmeEESmIDVFQTVRGLRQQRP
| ..  .. .   .| . ||.. .||  |||..  .| ....  . ... .| .|..|||||| ||||...|. ...    ..  ........ .|..||
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrp

HMVQDLAQFKFCYS
..|.   |..|.. 
gavpnpgqlrfLle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 409-529 3.1e-18 60.6 In-house 175-290 (305) alignment 
Range on Protein: 409-529
Range on HMM: 175-290/305.0
DIEISHAhMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkeqGpkPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVF-QTVRGLRQQRPH
 . |  .  .. ||. .||.  ||. ||| . . .. |..|.   .   |  ||||||||| ||||  . |. .. .. .  .|.   . .. .|.||  
vlviegp.gekarkvthyhwidwpdrgvpaadlailellekarpsk...g..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnn

MVQDLAQFKFCYSAMVEYLEEQ
 .|  ||. | .  ...|....
siqtdaqylfvhqvilnyfrkk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 410-526 3.7e-23 76.6 In-house 78-194 (440) alignment 
Range on Protein: 410-526
Range on HMM: 78-194/440.0
IEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMV
|. |.    . | ..|||..|||. |||.    ......     |.. |  |..||||||.||||| ||.. ..   .    ||.|  .  .|..||.||
inasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmv

QDLAQFKFCYSAMVEYL
|   |. | . |..| |
qtpeqyafvheavlegl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 422-526 1.1e-18 62.1 In-house 216-344 (350) alignment 
Range on Protein: 422-526
Range on HMM: 216-344/350.0
KIRQYHFRGWPEVG---VPESGIDLMR----L--VNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSR------MEEES-MID--------VFQT
 . | ... |....    ||| .  .     |   . ...| ...  .||.|||||| ||||....|. |.|       ...||  .|        ....
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|  ||.||  |||.| || |.| |.  | 
vnelrkqrismvqnldqfifiYeallfyf
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 422-527 5.4e-06 19.2 In-house 206-310 (346) alignment 
Range on Protein: 422-527
Range on HMM: 206-310/346.0
KIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGpKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSA
  . .|   |  .  |   . ..... . .  .. |    . |    |.||.  ||     . ....    .... .. ..||||  |. .||.   |. 
icqvhhhapwkhlqqppktlpiikmihqflsekqvqn.agvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai

MVEYLE
...|. 
vfdyia
PTPc_DSPc_SM00012 423-523 1.5e-34 113.7 In-house 2-104 (105) alignment 
Range on Protein: 423-523
Range on HMM: 2-104/105.0
IRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGP-KPIVVHCSAGSGRTGVFIALNVLMSRMEEE-SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYS
...||. |||. ||||.. ....|... . ......  ||.||||||| ||||.|.|| .|....|.| . .|.||.|. ||.|||.||| ..|. |.| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AMV
|. 
all
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 426-531 2.1e-15 50.9 In-house 186-290 (302) alignment 
Range on Protein: 426-531
Range on HMM: 186-290/302.0
YHFRGWPEVGVPESGIDLMRLVNKShLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
|..  |..  ||..  .|.. . |   ..|... ...|.    |.|| |.|..| | ........   . ..|. .|.|||..|. | |. . | |.. |
yvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly

LEEQST
. .. |
ikkkvt
0038934 (Phosphotyrosine protein) phosphatases II 427-519 3e-10 35.6 In-house 83-170 (194) alignment 
Range on Protein: 427-519
Range on HMM: 83-170/194.0
HFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRmeeeSMiDVFQTVRGLRQQRPHMVQDLAQFKFCY
.   .|. |.. |   |.| ..  . . .|. .. ..||| || ||||...|   ....     | .. . .. .|. ||....   ...  .
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrl....gm.saeeAialfrekRpgaipnqdyleall
subfamily_PTPDC1_pd Subfamily PTPDC1 430-520 4.2e-09 31.1 In-house 89-170 (182) alignment 
Range on Protein: 430-520
Range on HMM: 89-170/182.0
GWPEVGVP--ESGIDLMRLVNKSHLHQKeqgpkpIVVHCSAGSGRTGVFIALNVLMSRMeeesmIDVFQTVRGLRQQRPHMVQDLAQFKFCYS
||.. ||.  |. .|....|. .  ..|      . ||| || ||||| ||  .. ..      ..  .... .|..||. .|   | ...  
gwkDygvasleriLdivkvvafalqegk......vavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_PTEN_pd Subfamily PTEN 446-500 1.3e-06 23.5 In-house 101-157 (184) alignment 
Range on Protein: 446-500
Range on HMM: 101-157/184.0
LVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEES--MIDVFQTVRG
.|.. . . .|.  . .|||| || ||||| |.  .| |.. |..  ....|...| 
ivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 448-527 1.9e-15 51.0 In-house 254-345 (349) alignment 
Range on Protein: 448-527
Range on HMM: 254-345/349.0
NKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMS--RMEE--ESMID--------VFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
. ..|. ...   ...|||||| |||||.. |..|.|   . .     |.        .. .|  ||.||  |||.|||| ..| |...|. 
lfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_DSP11_pd Subfamily DSP11 449-514 1.7e-06 22.1 In-house 106-172 (178) alignment 
Range on Protein: 449-514
Range on HMM: 106-172/178.0
KSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVL-MSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQ
|..|.....  | | |||  |  ||| .|   .. .  .| |  |..|...||   .| . ..|| .
kefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkk
0048567 (Phosphotyrosine protein) phosphatases II 450-499 5e-06 21.0 In-house 65-118 (157) alignment 
Range on Protein: 450-499
Range on HMM: 65-118/157.0
SHLHQKEQGPKPIVVHCSAGS---GRTGVFIAL-NVLMSRMEEESMIDVFQTVR
. |.. |  .|.|.|||.||    |||...|..  .|  ..  |  |. .. ||
kflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
DSPc Dual specificity phosphatase, catalytic domain 450-511 6.5e-06 21.0 Pfam-A 64-120 (133) alignment 
Range on Protein: 450-511
Range on HMM: 64-120/133.0
SHLHQKEQGPKPIVVHCSAGSGRTGVFIALnVLMSRMEEeSMIDVFQTVrglRQQRPHMVQD
. ... ||  | ..||| ||  |.. .|.   ||....  |. . .. |   ...|..... 
efiekaeqkgkkvlVHCqaGisRSatliia.Ylmktknl.slneAyefv...kerrskispn
DSPc Dual specificity phosphatase, catalytic domain 450-511 6.5e-06 21.0 In-house 64-120 (133) alignment 
Range on Protein: 450-511
Range on HMM: 64-120/133.0
SHLHQKEQGPKPIVVHCSAGSGRTGVFIALnVLMSRMEEeSMIDVFQTVrglRQQRPHMVQD
. ... ||  | ..||| ||  |.. .|.   ||....  |. . .. |   ...|..... 
efiekaeqkgkkvlVHCqaGisRSatliia.Ylmktknl.slneAyefv...kerrskispn
subfamily_CG42327_pd Subfamily CG42327 452-525 1.5e-16 55.0 In-house 242-314 (319) alignment 
Range on Protein: 452-525
Range on HMM: 242-314/319.0
LHQKEQGpkPIVVHCSAGSGRTGVFIALNVLMSRMEEE-SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
 ....||  |.||||| | ||||. || .. . ..||    .|. |.|  .|..| . |..  |..| |  . ||
gtresqG..PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
Y_phosphatase3 Tyrosine phosphatase family 454-492 3.3e-06 22.2 Pfam-A 119-157 (164) alignment 
Range on Protein: 454-492
Range on HMM: 119-157/164.0
QKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMI
.  . ..|...||.||  ||||..||   .  ..|| ..
alaeeegpvlfHCtaGKDRTGvvaalllsllgvdeetia
subfamily_PRL_pd Subfamily PRL 454-498 8.2e-06 20.0 In-house 85-129 (151) alignment 
Range on Protein: 454-498
Range on HMM: 85-129/151.0
QKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTV
 ||.. . . ||| || ||. |..|| .. . |. |  ... .. 
fkeepkstvavhcvaGlGraPvlvalalieaGmkyedavefirek
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 458-525 2.3e-15 51.2 In-house 227-294 (297) alignment 
Range on Protein: 458-525
Range on HMM: 227-294/297.0
GPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
 . ...|||||| ||.|| .  .|.....  . . ||   .. ||.||. .|| | ||...|.|... 
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_eak_pd Subfamily eak 460-536 4e-07 23.7 In-house 238-315 (332) alignment 
Range on Protein: 460-536
Range on HMM: 238-315/332.0
KPIvVHCSAGSGRTGVFIALNVLMSRMEE--ESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEYQNF
 || . .. || |.|||. ...|.  ...  . .  | . .   ...| | |    |  | | ....||  .  .....
api.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 462-526 2e-17 57.4 In-house 1-65 (69) alignment 
Range on Protein: 462-526
Range on HMM: 1-65/69.0
IVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
.|||||.|.|||| |||. | |.|.  | ..|.|  |. .|. || || .  .. | . |.|| |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 463-526 4.6e-17 56.1 In-house 1-64 (69) alignment 
Range on Protein: 463-526
Range on HMM: 1-64/69.0
VVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|||||.|.|||| |||. | |.|.  | ..|.|  |. .|. || || .  .. | . |.|| |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal