Gene SpurPTPRA-like-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP108_AA protein Get Run
SpurP108_AA_2-251 phosphatase_domain Get Run
SpurP108_AA_264-527 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-278 1e-174 575.3 In-house 49-319 (319) alignment
Range on Protein: 2-278
Range on HMM: 49-319/319.0
PLATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTkciedgKDKCSQ
.||.....||..||||||.|||.|.|...|||....|.|.|||||||.|.|||..||.||||||.||||.|||||||||||||||.||      ||||||
nladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWPNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYI
|||.|.|||..|||||.|||.||||||.|...|||||||...|.|||||||||||.|.|||||..|.|.|.|||||||.||||||||||||||||||.||
ywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyi

VIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDD
|.|..||.||.|||||.|||..|.|||||||||..|||.||..|||||||||||||||||||||...||||||||||
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnksdfddd

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-279 3.9e-171 563.0 In-house 13-284 (284) alignment
Range on Protein: 2-279
Range on HMM: 13-284/284.0
PLATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTkciedgKDKCSQ
........||..||||||...|.|.|...|||....|.|.|||||||...|||..||.||.|||.||||.|||||||||||||||.||      ||||||
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsq

YWPNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYI
|||.|.|||..|||||.|||.|..|||.|...|||||||...|.|.|||||||||.|.|||||..|.|.|.|||||||.||||||||||||||||||.||
ywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

VIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDDL
|.|..||.||.|||||.|||..|.|||||||||..|||.||..||||||||||||||.||||||...|||||||||||
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnksdfdddl

subfamily_PTPN9_pd Subfamily PTPN9 2-248 2.5e-76 251.5 In-house 30-288 (297) alignment
Range on Protein: 2-248
Range on HMM: 30-288/297.0
PLATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQ
.  |...|.|. |  |||| ... ||.|||.|. .|. | ||||||..|.||. .. |||.||| ..| .|||||.|| .. .||| |...| |. ||.|
veGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgq

YWP--NKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEdGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKM----N-------HRANIVV
|||  .. ....| ..|.  .| |. .|..|......  |.  .|..| | ||.|||.| |.  . .. ... ||.  ...            .   |||
yWpleeessaefgdlsvsnveveeeedykvrvleikn.vkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivv

HCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|||||.|||||.| .|  |. .... .||. . .. .|.||   .|   || | ..|.||
hcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

0050432 (Phosphotyrosine protein) phosphatases II 3-250 3.1e-97 320.9 In-house 57-299 (308) alignment
Range on Protein: 3-250
Range on HMM: 57-299/308.0
LATMNHSNLPPNKDKNRYINIIAYDHTRVKLkptdGiEGSDYINASYVNGY--QSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCS
| ......|| ||||||| .|..|||.||||    . |||||||||||.||   .| ||||.|||..||.||||||.||.|...||||||..|.|. || 
lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekca

QYWPNK---GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKEtGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTskmnHRANIVVHCSAGVGRT
||||..   |...||.|.|.. |... ..|..| ..|.  |..   | .|.||...||||| |..|.... ....||.         .||||||||||||
qYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRt

GTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEH
||.|..| .|.....|. ||... .. .|.||.  ||.. ||.|...||||  
GtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

0036941 (Phosphotyrosine protein) phosphatases II 3-251 9.1e-94 309.3 In-house 28-278 (297) alignment
Range on Protein: 3-251
Range on HMM: 28-278/297.0
LATMNHSNLPPNKDKNRYINIIAYDHTRVKLkptDGiEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQY
| ......|| |..|||| .|..||||||||   |. |||||||||||.||. . ||||.|||..||.||||||.||.|...|||||...|.|. || ||
lgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WPNK--GVIKYGRFKVKMDSVTE--TAEYVIRSFQLSEDGKEtGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTG
||..  ....||.|.|.. ||..   ..|..| ....  |..  .| .|.||..|||||| |..|.... .|..||.  ....    ..|||||||||.|
wpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsg

TYIVIDAMLDMMK---HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
|.|..| ||....   .|..|||..... .|.||.  ||.. || |...||||  .
tfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk

subfamily_PTPRA_pd Subfamily PTPRA 4-278 5.6e-101 332.7 In-house 48-323 (330) alignment
Range on Protein: 4-278
Range on HMM: 48-323/330.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
||.. ..   ||.|||..||. ||..|| | . .|.| |||||||...||.  ||||||||||..|.|||||||||.. .||||||.  |  ..|| |||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PNKGVIKYGRFKVKMDSVTETAEYVIRSFQLS---EDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHraNIVVHCSAGVGRTGTY
|..|.. ||  .|... .|.. .| .| | .    .  .|  .| ..|||| .||| | |  |  |. |.|.|..|  ..     ||||||||||||||.
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGtf

IVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDD
||.||.|...| |..||...|.. .|.||  .||.  || ||. .||| .|.| ... .  .  . |.| ||    |.
ivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdk

0051299 (Phosphotyrosine protein) phosphatases II 4-248 4.2e-99 326.9 In-house 39-284 (288) alignment
Range on Protein: 4-248
Range on HMM: 39-284/288.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
 |.....|| |..|||| .|..|||.||||...||.||||||||||..||... ||||.|||..||.||||||.||.|...||||||..|.|. || |||
ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYw

PNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDG---KETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmNHRANIVVHCSAGVGRTGTY
|..|...||...|.. |... ..|..| ....  .   ..   | .|.||...||||| ||.|.... ....||.  .  ..   .|||||||||||||.
plggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtf

IVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|..| .|.....|. ||...... .|.||. .||.. || |...||||
ialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

0040438 (Phosphotyrosine protein) phosphatases II 4-279 7.5e-98 323.0 In-house 33-305 (317) alignment
Range on Protein: 4-279
Range on HMM: 33-305/317.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
 |.....|| ||||||| .|. |||.||||.|..|...|||||||||.|.. ..||||.|||..||.||||||.||.....|||||.. |.|. || |||
dtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYw

PNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmNHRANIVVHCSAGVGRTGTYIVI
|......||.|.|.. |..| |....| .... . ..  .| .|.||..|||||| |..|...  ....||.  .  ..   ..||||||||||||.|..
plgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaa

DAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDDL
. ||.....|..||... .. .|.||.  ||.. || |...|||| ..... .. ..... ....| ..  .||. 
ylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvk

0046845 (Phosphotyrosine protein) phosphatases II 4-250 5.2e-96 316.6 In-house 18-274 (284) alignment
Range on Protein: 4-250
Range on HMM: 18-274/284.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDG-IEGSDYINASYVNGY-----QSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKD
 ......|| |..|||| .|..|||.|||||..|| .|.|||||||||.||      .. ||||.|||..||.||||||.||.|...|||||...|.|. 
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

KCSQYWPNKG-VIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGR
||.||||..| |..||.|.|.. |...   |..| ..|.  | .   | .|.||...||||| |..|.... ... ||.| ....    |||||||||||
kcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgR

TGTYIVIDAMLDMMKHEK---QVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEH
|||.|..| .|.....|.    ||... .. .|.||.  ||.. || |...||||  
tGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

0047943 (Phosphotyrosine protein) phosphatases II 4-248 2.7e-93 307.6 In-house 28-270 (273) alignment
Range on Protein: 4-248
Range on HMM: 28-270/273.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLkptdGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
 |.....|| ||||||| .|..|||.||||    | .||||||||||.||... ||||.|||..||.||||||.||.|...|||||...|.|. || |||
ltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYw

PNKG---VIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTY
|..|   ...||.|.|.. |... . |..| ..|.  | .   | .|.||..|||||| |....... .|. ||.  .. ..   .|||||||||||||.
pleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtf

IVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|..| .||....|..||... .. .|.||   ||.. || |...||||
ialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

0043336 (Phosphotyrosine protein) phosphatases II 4-248 4e-90 297.3 In-house 35-275 (278) alignment
Range on Protein: 4-248
Range on HMM: 35-275/278.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
 |.....|| ||||||| .|..|||.||||....| ..|||||||||.||. |.||||.||| ..|.||||||.||....||||||.. |.|. || |||
dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYw

PnKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKE-TgqRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmNHRANIVVHCSAGVGRTGTYIV
| .|...||.|.|.. .... . |..| . ..  |.  .  | .|..|.||||||| |. .|... ..|.||.  .  .    ..||||||||||||.|.
p.ggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfia

IDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.. .|.....|. ||... ....|.||   ||.. || |...||||
lyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

0045450 (Phosphotyrosine protein) phosphatases II 4-248 4.2e-89 294.6 In-house 45-302 (307) alignment
Range on Protein: 4-248
Range on HMM: 45-302/307.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGI-EGSDYINASYV--------NGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIED
 ......|| ||||||| .|..||||||||...||  |.|||||||||        .|| ...||||.|||...|.||||||.||.....|||||...|.
geysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvel

GKDKCSQYWPNKG-VIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAG
|. || ||||..| .. ||.|.|.. |... ..|..| . ..  ...   | .|.||..|||||| |......  .|..||.  .. .    ..||||||
grekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaG

VGRTGTYIVIDAMLDMMKHEKQ---VDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
||||||.|... ||.....|.    ||... .. .|.||   ||.. || |...||||
vgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

0045098 (Phosphotyrosine protein) phosphatases II 4-251 2.1e-83 275.2 In-house 23-273 (278) alignment
Range on Protein: 4-251
Range on HMM: 23-273/278.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKlkptdgiegsDYINASYVNGYqsPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
 ........ |.||||| .|..|||.|||          |||||||..||  |.||||.|||...|..|||||.||.....|||||...|.|. || |||
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSED---GKETGQRSITQFHFLGWPDHGQPDYP--SPMMCLIKRVRHLTS-----------KMNHRANIV
|..|.. ||.|.|.. |.... .|..| . .       ..  .| .|..|.|.||||| |..|  ...  |....|.  .            ...   ..
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSAGVGRTGTYIVIDAMLDMMkhEKQVDIYNFIHDIRQQRNT-LVQSFVQYFFIHMALLEEHL
||||||||||||..... ||...  |..||... .. .|.||.   ||.. || |....||| .|
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_PTPN3_pd Subfamily PTPN3 4-247 3.4e-73 241.0 In-house 31-272 (280) alignment
Range on Protein: 4-247
Range on HMM: 31-272/280.0
ATMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDgiEgsDYINASYVN----GYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKC
 .......| | .|||| .|..||.|||||| ..     |||||.|||    . .   ..||.||| ..| .|||.|.|| ..|.|||||  .|.|. ||
laisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

SQYWPNK-GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhrANIVVHCSAGVGRTG
 ||||..   ..||.|.||. .  || .||.| . |..  ... .|.|.|. .| ||||| || .. .. ...|||.| | ..    .|||||||.||||
hqyWPetedeleygefsvkcekedetksyvlrelvlkdk.etkeerkilqlqylaWpdhgvPddsadflefvervrklrsgke..ePvvvhCsaGigrtG

TYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
 .|...  | .. ....| . . .. .|.|| .|||.  || |.  |.|
vlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail

subfamily_PTPRD_pd Subfamily PTPRD 5-289 1.9e-123 408.1 In-house 39-319 (564) alignment
Range on Protein: 5-289
Range on HMM: 39-319/564.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP
|....| | || |||| ||.||||.||.|....| |||||||||...||... ..||.|||. .|.||||||.||.|.||||||||. | ||.||..|||
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

NKGVIKYGRFKVKMDSVTETAEYVIRSFQLsEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTsKmNHRANIVVHCSAGVGRTGTYIVID
.||  .||...|.. . .| |.|.||.|.| .. |.  .| ..||||  |||||.|... ... ||..||.|. . ...  ||||||||||||||.||||
ekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.pdagPivVhCSaGVGRTGtfivid

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDfDDDLTKLEVEFRRA
|||. .|.||.||||.... .|.|||..||.  ||.||| |.||   .|. .| . .. .  |.|..... | . |.||.||.| 
amlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaevee.dtemtgleleFqrL

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 5-288 1.9e-102 337.6 In-house 37-317 (318) alignment
Range on Protein: 5-288
Range on HMM: 37-317/318.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP
|  .|. | || ||||.||.|||||||||....| ||||||||.|..||..  ..||||.|  .|.||||||.|| |...|||||.. | ||.|. .|||
tslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP

NKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEdGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhRANIVVHCSAGVGRTGTYIVID
.|| ..||. .|.... .|...||.|.|....  .|  .| . |.|.  |||.| |. .. .. |...|..   | . .  |||||||||||||..|..|
skgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg.agpivvhCsaGvGrtGvfiavd

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNkSDFDDDLTKLEVEFRR
..|. .|.|. ||...... .|.||| .||   || ||. .|||    |...|   |. .  ..| . .| .   |....||.|
illerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre.qdpesgttemdaefqr

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 5-286 1.7e-98 324.6 In-house 39-318 (319) alignment
Range on Protein: 5-286
Range on HMM: 39-318/319.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP
|..... . ||.|||| ||.|||.|||.|.. ||.|||||||||...|||  .||||.|.|..||.||||||.||...|..|||||  | .| |...|||
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp

NKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRaNIVVHCSAGVGRTGTYIVID
.. . .|||. |....  |...|.|| ..| .   |   |....|... ||||. |..   .. |.||.|. ..| ...  ||||||||||||||.||.|
eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg.PivvhCsaGvGRtGtfivld

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKsDFDDDLTKLEVEF
|||. .|.|  .|.....  .| |||..||   || ||. ||||   .|.... . |.    .||..| . |   |.|| ||
amlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaek.vadtgetgleref

subfamily_PTPRG_pd Subfamily PTPRG 5-251 6.5e-92 303.5 In-house 38-288 (563) alignment
Range on Protein: 5-251
Range on HMM: 38-288/563.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGS-DYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
...||. | || ||||.||.|||..||||.|. |.... |||||.|..|||  ..|||.|||  .|..|||||||| | ..|||.|.  |.|. || .||
daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYW

PNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSE----DGKE-TGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVrhLTSKMNHRANIVVHCSAGVGRTG
|. ....|| ..|.. .   .| | .|.... .    ..|.   .. ..|.|.  ||||| |... | .  .|.    ......   |||||||||||||
PkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaGPivvHcsaGvgrtG

TYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
||||.|..|  ...|..|....|.. || ||| |||.  || |.| ||||  .
tyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia

0040439 (Phosphotyrosine protein) phosphatases II 5-248 7.7e-87 286.2 In-house 2-244 (249) alignment
Range on Protein: 5-248
Range on HMM: 2-244/249.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP
......|| ||||||| .|..|||.||||....| ..||||||||..||.....|||.||| ..|.||||||.||.....|||||.. | |. || ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVID
..|...||.|.|.. ||.. ..|..| ..|.   ..   | ........||||| |....... .|..||.  .. .    ..||||||||||||.|...
lggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
 ||.....|..||... ....|.||.  ||.. || |...||||
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

subfamily_PTPN14_pd Subfamily PTPN14 5-247 2.1e-63 209.1 In-house 40-293 (300) alignment
Range on Protein: 5-247
Range on HMM: 40-293/300.0
TMNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIeGSDYINASYVNGYQSP--DKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQY
... ..|| |..|||. ... |...||.|.||     ..||||| ..   .    ..|.|||| ..|..|||.|.|| . . |||||. .||||.|. .|
llstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPNK----GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRA-------NIVVHCS
.|..      ...|.|||    ....  .. ....|        .|..  . .  ||||| |. .....  ...|. .  |.|.          ..||||
fPkleskkktvefgkfkvttkfsedsdsvittglklkhl.pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

AGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
|||||||  |. | ..  ..|....|| . .. .|.|| .|||.. || |.. .|.
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli

subfamily_PTPRB_pd Subfamily PTPRB 6-248 1.5e-95 314.6 In-house 43-283 (293) alignment
Range on Protein: 6-248
Range on HMM: 43-283/293.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN
.. ..|. |..|||| ||..|||.||||..... .|||||||.|..||.|| .|||.|||  .|..|||||.|| ..|.|||||...| || || .|||.
vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa

K-GVIKYGRFKVKMDSVTETAEYVIRSFQLSEdgkETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVID
.   . ||  ||.. . .|. ..|||......   |. .|...|.||. ||||| |. ..... ....||. ..| .... ||||||||||||||.| .|
deepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfiald

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
 .|. ...|  |||. .....|..||.|||.  || ||| ..|.
rllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld

0039614 (Phosphotyrosine protein) phosphatases II 6-251 1.2e-91 302.5 In-house 48-290 (297) alignment
Range on Protein: 6-251
Range on HMM: 48-290/297.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGI-EGSDYINASYVNGYQS-PDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKdKCSQYW
. ...|| |||||||..|..|||.|||||| ||  ..|||||||||.||   ..||||.||| ..|.||||||.||.....||||||..|.|. || |||
ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqyw

PNKGViKYGRFKVKMDSVTETAEYVIRSFQLSEDGKEtgqRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVI
|..|  .||.|.|.. .|.. . |..| . .. .|..   | .|.|...|||||| |.... .. ... ||.  .. .    ..||||||||||||.|..
peegg.tygdftvtllkvehldgytvrtlevtnnges...rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaa

DAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
. ||.....|..||... .. .|.||.  ||.. || |...||||  .
ylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

subfamily_Ptp69D_pd Subfamily Ptp69D 6-269 2.1e-89 294.7 In-house 40-305 (307) alignment
Range on Protein: 6-269
Range on HMM: 40-305/307.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN
 . |.   |. |||| .|.|.|.||||||.. | | |||||||...||.   ||||||.| ..|..||||||.| .  .||||..  |  ..||..|||.
tkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpi

KGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKET----GQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMnhRANIVVHCSAGVGRTGTYI
   ..||   ||. |  .. .|.||....|. ..|.     .| ..|.|..||.|   |. .  .. ||..||.| ..   |. |||||||||||.|...
edevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvgrsgifv

VIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQL
 .| .|. .| |..|||.....|.|.||| ||||. || |.. |||. . .|..|... |.   ...|
aldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl

DSPc_SM00195 6-248 3e-88 290.9 In-house 18-260 (263) alignment
Range on Protein: 6-248
Range on HMM: 18-260/263.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN
..... . ||.|||| ||. |||||||||.... ||||||||.|..|.... |.||.|||...|.||||||.|| ....|||||.. |.|| ||..|||.
tteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpe

K--GVIKYGRFKVKMDSVTETA-EYVIRSFQLSEDGKeTGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMnhRANIVVHCSAGVGRTGTYIV
.  |  ..|...||. .|...  |...| ..|...||   .|..||... .||||| || ..... |.. |.. .|.    . ||||||||||||||...
esggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvt

IDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|| .|. ...||.||| . .  .|.||  .||.. || ||..|.||
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 6-248 3e-88 290.9 In-house 18-260 (263) alignment
Range on Protein: 6-248
Range on HMM: 18-260/263.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN
..... . ||.|||| ||. |||||||||.... ||||||||.|..|.... |.||.|||...|.||||||.|| ....|||||.. |.|| ||..|||.
tteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpe

K--GVIKYGRFKVKMDSVTETA-EYVIRSFQLSEDGKeTGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMnhRANIVVHCSAGVGRTGTYIV
.  |  ..|...||. .|...  |...| ..|...||   .|..||... .||||| || ..... |.. |.. .|.    . ||||||||||||||...
esggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfvt

IDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|| .|. ...||.||| . .  .|.||  .||.. || ||..|.||
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

0037934 (Phosphotyrosine protein) phosphatases II 6-248 2.4e-76 251.8 In-house 2-240 (243) alignment
Range on Protein: 6-248
Range on HMM: 2-240/243.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLkptdgiEGSDYINASYVNGYqspDKFIAAQGPKDNTLED----FWRMIWEYNCSTIVMLTKCIEDGKDKCSQ
.....|| |..|||| .|..|||.||||      ||||||||......   ...|| ||| ..|.||    ||||.||.....|||||...| |. || |
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPNKGviKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSK------MNHRANIVVHCSAGVG
|||..    ||.|.|.. |......|..| ..|.  . .  .| ....|.|.||||| || |.... ... ||   ..       ..   ..||||||||
ywpgev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTYIVIDAMLDMMkhekQVDIYNFIHDIRQQRNT-LVQSFVQYFFIHMALLE
||||.|... ||...    .||... ....|.||.   ||.. || |...||||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 6-247 2.8e-67 221.7 In-house 20-265 (274) alignment
Range on Protein: 6-247
Range on HMM: 20-265/274.0
MNHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEG-SDYINASYVNGYQSPDK-FIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYW
... ... .. |||| .|.  ...|| |.. .. .  |.|||| |. ||.  .| ..|.|||  ||..||||||.. ... ||||||  |  ..||..|.
qeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyf

PNKGVI----KYGRFKVKMDSVTETAEYVIRSFQLSEDGKetgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHR-ANIVVHCSAGVGRTG
|..  .    .|| ...|.....|. .| .|.. |..  .   .||.. . .  |||| .|| ..... |.. |..  .. |.. | .|||||||.||||
Pdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

TYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
 .| |.  .  ...|. ||. . . ..|..|  .||.  || .|| || 
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

0049772 (Phosphotyrosine protein) phosphatases II 6-249 7.5e-48 159.2 In-house 38-279 (314) alignment
Range on Protein: 6-249
Range on HMM: 38-279/314.0
MNHSNLPPNKDKNRYINIIAYDhTRVKLkPTDGIEGSDYINASYVNGYqspDKFIAAQGPKDNTLEDF----------WRMI--WEYNCSTIVM------
.  ..|..|.|||||..|. .| .||.| |. ...||||||||||.|.    ||||.|||...|..||          |||.  ...|. .|||      
ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LTKCIEDGkdkcsqywPNKGVIKYGRFKvkmdsvteT----AEYVirsfqlsedgketgQRSITQFHFLGWPDHGQPdYPSPMMC
               |... . |        .   .  .  .|        .    .|..              .| . ... . .||...|  .. .  
adelsrLdaAlgKtpllildgng........neptaadlellk........eelydpelf..............erlgikylripvpDgsap.lledfde

LIKRVRHLtskmNHRANIVVHCSAGVGRTGTYIVIDAMLDMMkhekQVDIYNFIHDIRQQRN-----TLVQSFVQYFFIHMALLEE
... .. .    .   ...|||.||.|||||..|.. ..  .    .|..   ..|.|..|       ..... || ||..|||| 
flefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 7-247 9.5e-89 292.2 In-house 40-276 (288) alignment
Range on Protein: 7-247
Range on HMM: 40-276/288.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK
. ..|. |..|||| ||..||..|||||  .  .|.|||||||..|...  |.||.|||  .|..|||....|.. |||||||. .|.|| || .|||..
tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda

GV-IKYGRFKVKMDSVTETAEYVIRSFQLSedgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHlTSKMNhRANIVVHCSAGVGRTGTYIVIDA
.   .|| ..|.. .. |. ..| |.. |    |..... |||...|.||||| |.   |.. |.. |   ... .   .|.||||||||||||.|..||
dkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkv.anqad.tgpiivhCsaGvGrtgtFialda

MLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
..|....|...|. .... .|.||..|||   || ||. .||
lidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

0042113 (Phosphotyrosine protein) phosphatases II 7-248 1.9e-85 281.4 In-house 2-241 (245) alignment
Range on Protein: 7-248
Range on HMM: 2-241/245.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK
....|| ||||||| .|..||||||||.|..| ..|||||||||.||. ..||||.||| ..|.||||||.||....||||||.. |.|. || ||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmNHRANIVVHCSAGVGRTGTYIVIDAM
....||.|.|.. |..  ..|..| .... . ..  .| ....|.|.||||| ||... .  ....||.  .. .    ..||||||||||||.|... |
esltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylm

LDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
|.....|. |.... ....|.||   ||.. || |...||||
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 7-248 1.5e-70 232.4 In-house 39-281 (290) alignment
Range on Protein: 7-248
Range on HMM: 39-281/290.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEG--SDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP
.. . . || .||. ||. ||  |. |.|  | .    .||||.|..||.   ..||.|||  ||| |||..||. ... |||||. ||.||.|| ||||
tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWp

NKGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhRANIVVHCSAGVGRTGTYIVID
.... .|| |..|. . ... ||..| ... .. ..  ..|.||...  |...|.   |. .. .|... .   |   .  ||||||..|||........
dsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHCSdtvgrsavfcaaa

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
  .. .| | ..|... ..  |.|.  .||. .|| .|.  .|.
ttinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt

subfamily_PTPN1_pd Subfamily PTPN1 7-256 7e-63 207.0 In-house 25-277 (290) alignment
Range on Protein: 7-256
Range on HMM: 25-277/290.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGiegsDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK
....|| |...||| ..  |||.|.||. .|     |||||| |.  .   ..| .|||  || . ||.|.|| .. ..||| |..| .. || ||||..
reaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

G---VIKYG--RFKVKMDSVTETAEYVIRSFQLsEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYI
     ...   ..|||. |  .. .|..| ..| |. |    |.|..||.. ||| | |. |. .. .. .||.  |  ..    |.|||||.||.||..
eeekellledtklkvkliseerksyytvrllel.enlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfc

VIDAMLDMMKHEKQ---VDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSD
..|..|  ......   ||| . . ..|..|  |.|   |  | ..|.||   . ..|
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgd

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 7-248 1.4e-40 133.7 In-house 30-267 (281) alignment
Range on Protein: 7-248
Range on HMM: 30-267/281.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKP-TDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN
   | | |. ||||.|| . | .||.||      . .||| | |.        .| .|||| .|  |||||||. | ..|||| . .|  ..||..|.| 
tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr

K--GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKeTgqRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltskmnHRANIVVHCSAGVGRTGTYIVI
.   .... .. |. .  |     |   ..|| .|. |  | ||.. .  |||   |.    |. .....|       . .  |.||||||||.|| . .
nahcclqfdklsvsyedstvnkslvttrlnlsyege.t..rlithwlwkewpdwqvpessevmlkilrkira......rstppvihcsagvgrsgtlmav

DAMLD-MMKHEKQVDIYNFIHDIRQ-QRNTLVQSFVQYFFIHMALLE
.  |. .  |    || . .  .|   | . ||.. ||..|   ||.
eialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_egg_pd Subfamily egg 7-277 4.9e-31 102.5 In-house 33-299 (307) alignment
Range on Protein: 7-277
Range on HMM: 33-299/307.0
NHSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDgkDKCSQYWPNK
...    |..| |   .   | .||||.   |    |.| | .|.|    ..|| || |  || .|||||... ..  |||||   |   ..|  |||. 
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

--GVIK--YGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHflgWPDHGQPDYPSPMMCLiKRVRhltskmNHRANIVVHCSAGVGRTGTYIV
    ..   | ....   | ..|. . |  .|   | .  .| .  .    .  .   |  ||.  | ...|      |    .||..  || ...| . 
esdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq...gdvnnssdvysplrvl.rklr......nlskpvvvqdilGvskaatlva

ID-AMLDMMKH-EKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL--EEHLFGHSDVAMPDFPAYYQQLSNKSDFDD
|. |.|....    .  . . .  .|..|.  |.| ..|.|..  .|     . | .     |.  . .. |.|  .||
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdyerwleersekmfldd

subfamily_PTPN12_pd Subfamily PTPN12 8-248 2.7e-76 251.2 In-house 34-275 (290) alignment
Range on Protein: 8-248
Range on HMM: 34-275/290.0
HSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG
... . |. |||| .|. ||..||.|. ... ||||||||....| ... ..||||||  .||.||||||||.| . .||. . .| || || .|||..|
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

--VIKYGRFKVKMDSVTETA-EYVIRSFQLSEDgkeTGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmNHRANIVVHCSAGVGRTGTYIVID
   ...| |.|....   .  ...||....  .     .|...|||.  ||||| |  ..... ||. ||.| .  .. | .||||||||||||| |.||
eeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaid

AMLDMMKHEKQ---VDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
 . ...|.||    .|... . ..|.||..|||.  || ....|..|
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 8-274 9.4e-73 239.8 In-house 38-301 (315) alignment
Range on Protein: 8-274
Range on HMM: 38-301/315.0
HSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN--
 .  . |  |||| ||. .|..||||.  | .  ||||||||......   .||.|||.. ...|||||..... .||||.||  |. | || ||||.  
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrk

KGVIKYGRFKVKMDSVTETAEYVIRSFqLSEDGKEtgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLtsKMNHRANIVVHCSAGVGRTGTYIVIDA
   ...| .||.. |.  ... |.| .    ...|  .| .|||.| .|||.| .   | .. ||| |.    . ..  ...|||||||||||  | || 
adsvefGsikvellsleadtdgvarkl.vtrksee..srtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvviside

MLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSD
... .|... ||..||.. .|..|  |||.  .| ||. |.||. |.  . . .  |  . |.|   .|
vvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvd

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 8-55 1.8e-12 41.3 In-house 41-88 (440) alignment
Range on Protein: 8-55
Range on HMM: 41-88/440.0
HSNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQS
 ..|| || |||| ||.||||.|| |.   |.  ||||||||.|| .|
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 9-249 1.5e-88 292.0 In-house 51-289 (298) alignment
Range on Protein: 9-249
Range on HMM: 51-289/298.0
SNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGV
.. | ||.|||| .|||.|..|| |. .|. | |||||||....|.  . |||.|.|  .|.||||||..|.. .||||||.  | .| |...|||..| 
arkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk

IKYGRFKVKMDSVTETAEYVIRSFQLSEDGKEtGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHlTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLD
 .||...|.. |  | |....| ...|.  .| ..|.. |.||  |||.| | . . .. |...||  . . .  . ..|.|||||||.||.|.||..|.
etygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvle

MMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
 .|.|. ||... .. .|..| ..||.  || ||..| || 
rvkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 9-248 1e-83 275.7 In-house 36-274 (281) alignment
Range on Protein: 9-248
Range on HMM: 36-274/281.0
SNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG-
|. . |. ||||.||.|||.||||..|..  . .|||||..|.||... ..||.|||  ..|..||.|.||.. |.|||.|. || || || .|||..  
skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns

VIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKEtgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHrANIVVHCSAGVGRTGTYIVIDAML
 .||| ..||. . .|.|.|. | |.|.... |  .|...|.... ||||| |. .. ..   | |..||.| .. | .|.||||||||||||| .| ..
elkygdvtvkstaeeekatyierkfkleresge..treveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtGtyialDrlv

DMMKHE-KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
. ...| ...|. . ....|..|| .||. ||| |.. |.|.
kaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld

subfamily_PTPN6_pd Subfamily PTPN6 9-246 2.8e-79 261.3 In-house 49-293 (306) alignment
Range on Protein: 9-246
Range on HMM: 49-293/306.0
SNLPPNKDKNRYINIIAYDHTRVKLKpTDGIEGSDYINASYVNGY--QSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK
.. | || |||| ||. .|||||.||  ... |||||||.|...   .|  ..||.||  ..|..|||||.|. |.  |||.|| .| ||.||..|||..
gakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde

GVI-KYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMN--HRANIVVHCSAGVGRTGTYIVI
    .||. .|.. | ...|.|..|....|.  |.. .|.. |.||  ||||| |  |. .. ... |.. .....  .   ||||||||.|||||.|||
eekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfivi

DAMLDMMKHE---KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMAL
|..|......    ..||..... .|.||. |||   || |...|.
Dillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 9-279 1.3e-74 246.3 In-house 43-317 (325) alignment
Range on Protein: 9-279
Range on HMM: 43-317/325.0
SNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMlTKCIEDGKDKCSQYWPNK--
. .| ||.|||. |..|.|..|| |.  .    ||||||||.. ..  | |.||| |. .|..|.||.. ...|| .|. .  .. |||.|..|||..  
amkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavywpkemg

GVIKYGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNH----RANIVVHCSAGVGRTGTYIV
   ..| ..||. .. | ..|| | ... .  |.   ||. ||.. .|.| |.. .|. .. ... | ..  ...      . |.|||||||||||..| 
ksktfGglevklrtieeisdyvhrvldvkqv.kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

IDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDDL
. ..|. . .| .|||..|.. .|..| ..|..  || .|. || |  . | .|| .  | |    | ..  . . |
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqkl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 9-287 2e-58 192.7 In-house 40-272 (392) alignment
Range on Protein: 9-287
Range on HMM: 40-272/392.0
SNLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGkdkcsqywpnkgv
.. . |. |||| ||. || .||||.  | |  |||.||||......   .||.|||.  .|.|||||... | .||.|.||  |               
aqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.............

ikygrfkvkmdsvtetaeyvirsfqlsedgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHraNIVVHCSAGVGRTGTYIVIDAMLD
                              |   .|...||||  |||.. | . | .. .|| |.    .  |   ...||||||||||  | ||... 
..............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth..pliihcsagvgrtgvvisidsvva

MMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDdLTKLEVEFR
  |. . ||..||. .||..|  .||.  || ||. |.||. |.  . . .  |  . |.||  || |   .|   |||
hakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdv.rskqlkefr

subfamily_PTPRN_pd Subfamily PTPRN 10-249 1.2e-59 196.5 In-house 52-291 (297) alignment
Range on Protein: 10-249
Range on HMM: 52-291/297.0
NLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQS-PDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGV
. . | .|||. ....|||.||||| .   | ||||||| .   .     .||.|||  .|. |||.|.||  .  ||.||.  |.|  .|..|||..| 
kaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGs

IKYGRFKVKMDSVT-ETAEYVIRSFQLSEdGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltSKMNHRANIVVHCSAGVGRTGTYIVIDAML
  |. ..|.. |    . .|..||| | .  . .  |..|||||| ||..| |  . ... . ..|    |     . ||||||.|.||||.||.|| .|
evyhiyevhlvsehiwcddylvrsfylkn.lqtsetrtvtqfhflswpeegvPasaksllefrrkvnk..syrGrscpivvhcsdGaGrtGvyilidlvl

D-MMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
. ..|  |..||   .  .|.||. ||..  |. |. .|. ||
nrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 10-252 8e-49 161.3 In-house 37-279 (307) alignment
Range on Protein: 10-252
Range on HMM: 37-279/307.0
NLPPNKDKNRYINIIAYDHTRVKLKpTDGIeGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVI
 .  | ||||| .. . |..|. .| .||.  |||| | |.     | |||.||||..||  .|| |. . .  ...|| |.|| .| || |||| .   
afsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

K--YGRF--KVKMD--SVT--ETAEYVIRSFQLSEDGkETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltskmnHRANIVVHCSAGVGRTGTYI
|  .|     . ..   .      | .|   .|  |    . |.|... .  |||.| |.     . |.. ||       ..  .||||||||||.|| .
klvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltainlleavry......dtnpvvvhcsaGvGrsGtiv

VIDAMLD-MMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLF
 |  . | |.. .   |. ......|.||.  .|. .||...|  |||  | 
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 10-107 1e-11 38.0 In-house 23-88 (169) alignment
Range on Protein: 10-107
Range on HMM: 23-88/169.0
NLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINAsyvngyqspdkfiaaqgpkdntledfwRMIWEYNCSTIVMLTkcieDGKDKcSQYWPNKG
.|  |. |||    .|  ||||||.      |||||||                           ||||| | | ||.|     |  ||  ..||.| 
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlg....dtddk.nnfwpeke

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 10-107 1.5e-11 37.4 In-house 22-87 (169) alignment
Range on Protein: 10-107
Range on HMM: 22-87/169.0
NLPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINAsyvngyqspdkfiaaqgpkdntledfwRMIWEYNCSTIVMLTkcieDGKDKcSQYWPNKG
.|  |. |||    .|  ||||||.      |||||||                           ||||| | | ||.|     |  ||  ..||.| 
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlG....dtddk.nnfwpeke

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 11-249 2e-82 271.2 In-house 6-241 (250) alignment
Range on Protein: 11-249
Range on HMM: 6-241/250.0
LPPNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDkCSQYWPNKGVIK
 | ||.|||| .|||.|..|| |....| . |||||||...||.  . |||.|||  .|.||||||..|.. .||||||.  | .|  ..|||| ..  |
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

YGRFKVKMDSVTETAEYVIRSFQLSEDgKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhRANIVVHCSAGVGRTGTYIVIDAMLDMM
||  .|.. |  | |.|..| ..||.  |....| . |.||. ||| | |..   .. |.|.|.    . .  | ..|.|||||||.|..|.|||.|. .
yGdvtvsllskeefadytkrklklska.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqag.naPvivqCsaGvgrsGafiaidavlerl

KHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
|.||.||....|. .|..|   |.|  || |.....|. 
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 11-248 2.6e-68 225.1 In-house 44-276 (287) alignment
Range on Protein: 11-248
Range on HMM: 44-276/287.0
LPPNKDKNRYINIIAYDHTRVKLKptdgIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIK
 . ||||||. .|. .|  || ||     |  |||||....||..  .||.|..|  ||. .||..|.. | ..||||..  |. ...| ||||..  . 
asqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvv

YGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHlTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMM
.| ..... . . .|.|..| ... ...|.. .....|...  |...|.   |  .. .|..  . | . . .. ||||||..|||..... ..  ..  
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk.tqrkrgntsivvhCsdtvGrsamfcaaattinkc

KHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
| |  .|... ..  |.|. . ||   || ||  ..||
kteGviDvfqvlksqriqkpgsvqtveqykfindivle

subfamily_PTPN13_pd Subfamily PTPN13 11-248 4.8e-67 221.1 In-house 34-267 (273) alignment
Range on Protein: 11-248
Range on HMM: 34-267/273.0
LPPNKDKNRYINIIAYDHTRVKLKPTDGiegsdYINASYVNGYQSPDKF--IAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN---
   ||||||| |.. ||.|||||.   |     |||||...     |..  ||.|||  .| .|||.|.|| ... |.|.|.  |.|| || .|||.   
kkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPeskn

KGVIKYGRFKVKMDSVTETAEYVIRSFQLSeDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmnHRANIVVHCSAGVGRTGTYIVIDA
| .  ..|..|..  |..  ..|.|..... | . .  | .....|  ||||| |  . ... ....||.| .   ... ||||||||.||.||.|.||.
kklkvsnrlevellkvqkldgfvvralavk.dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrsGtlitidv

MLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.|......|..|. . ....|.||...||.  || |.. |.||
vlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 11-244 5e-36 119.0 In-house 47-275 (301) alignment
Range on Protein: 11-244
Range on HMM: 47-275/301.0
LPPNKDKNRYINIIAYDHTRVKLKpTDGIEgsDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GV
   .|||.|| ..    .| |..  .||      | | ...    |..|||.||| .|| |||| |.  |.  .||||.. .|. ..||..| | |    
aylpkdkhryptvPckPstavevi.vdGkr..vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

IKYGRFKVKMDSVTETA--EYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltskmnHRANIVVHCSAGVGRTGTYIVIDAM
.. ||||.|. .       . . |.... .  ..   |..| . .  |.|.| |     .. |.. |..       .  ||||||||.||. ..|  . .
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk......sekPivvhcsaGiGrsvafigteyl

LDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHM
   .. ...... . ....|..| . ||   | ... .
areveadptieltealkhlrehrwngvqtnsqlywmtl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 11-263 6e-20 66.1 In-house 44-293 (303) alignment
Range on Protein: 11-263
Range on HMM: 44-293/303.0
LPPNKDKNRYINIIAYDHTRVKLkpTDgiegSDYINASYVNgYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVML-TKCIEDGKDKCSQYWPNKGVI
.  | ||||....|  ||..|||  .|    | || |||..  .|  | | .| |   |  |||.|| | .   ...| | .  |     | .  |.  .
fvknmdknrfvdvicldhskvkl..sd....ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

KYGRFKVKMD---SVTETAEYVIRSFQLSEDgkeTGQRSITQFHFLGWPDHGQPDYPSPMM-CLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVID-
|.    ...     |  .  .|..   .|.    . .  .   |.  ||    |   || .   | ... .  |  .    |    .|.||.||. ... 
kfeersirvgefkrvelgdgwvlkvlsvsng...dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfet

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHmALLEEHLFGHS--DVAMPDFP
| | . . .  .|. . .  .|. |   || . |. ... .|| ||...     .|.|  |
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvy.tllaehvldngicklaipkkp

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 11-54 6.7e-09 29.7 In-house 36-78 (244) alignment
Range on Protein: 11-54
Range on HMM: 36-78/244.0
LPPNKDKNRYINIIAYDHTRVKLKPTdGIEGSDYINASYVNGYQ
|  |  |||||||. .|.||| |  .   ||||||||.|..| |
lsanatknryinilpfdetrvilsss.kkegsdyinanyiqgsq

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 12-250 4.7e-37 122.5 In-house 33-270 (285) alignment
Range on Protein: 12-250
Range on HMM: 33-270/285.0
PPNKDKNRYINIIAYDHTRVKLKPTDgiegSDYINASYVNGY-QSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GV
  | | ||| .. . . ||| ||  |     ||| ||..    .    .|..|||  .|| |||.||.. . . ..||   .| | .||. |.|.|   |
eanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

IKYGRFKVKMDSVTETA--EYVIRSFQLSEDGKETGQ-RSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmnhRANIVVHCSAGVGRTGTYIVIDA
.|.|.... .  . | |    .. .. . .    . .   . . .   |||.  |.   ||. | | |...  |      |.|||||||||| |.. || 
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk...ekpicvhcsagvgrtatfvgidy

MLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEH
    .  . .... . ....|  |   |||..|..|... |.|  
atirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 13-269 5e-82 270.3 In-house 48-298 (315) alignment
Range on Protein: 13-269
Range on HMM: 48-298/315.0
PNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIkYG
 ||.|||||||||||..||.|  ..  ..|||.||....||. ....||||||. ....||||...|.....|||||. .|. | |. .|||.| || ||
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkvi.yG

RFKVKMDSVTETAEYVIRSFqlSEDGKEtGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLtsKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKH
.. | . |     || .|..  |   ..   | . |.|.  ||| | | |  |.| ||..|.    . |  . ||||||||||||||.| .||.|| .. 
kitvtrkseevnteytvrtl..svvfgd.nirevvqlhytswpdmgvpkytiplmnlirtvkqh..htnsvgaivvhcsaGvGrtGtfitldavldqaea

EKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQL
|. .|.||||. .||.|  .||.  || ||. ||||  . | . .|   .   |. |
enaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 13-261 1.7e-61 202.6 In-house 32-277 (283) alignment
Range on Protein: 13-261
Range on HMM: 32-277/283.0
PNKDKNRYINIIAYDHTRVKLKPTDGiegsDYINASYVN---GYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVI
 || |||. .|...|  ||.||.       |||||...     |.   |.|.||.| |.|  |||.|... . ..||||||  || . |||||||..| .
enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse

KYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQpDYPSPMMCLIKRVRHLTSKmNHRANIVVHCSAGVGRTGTYIVIDAMLDM
.|| | | .   |    ..|. . |  ..    .  .. . . .| . |. . .   .  . .|. |  . .... ||||||.|.|||...| . | .. 
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyge.qaiinslvkfnkvislqte.skkgPivvhCstgiGrtavfiaasasvkd

MKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPD
.. |  ||... .. .|.|| ..||.  || ..| . ||. | | ...|. |
altesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavd

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 13-248 1.5e-49 163.4 In-house 32-257 (267) alignment
Range on Protein: 13-248
Range on HMM: 32-257/267.0
PNKDKNRYINIIAYDHTRVKLKPTDgiegSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCiedGKDKCSQYWPNK--GVIK
 |...||. . . ||.||| |. ..     .|||||||.||.   .||. |.| .||  ||. .| ......||.|||    ..|.  ..|| |     |
knqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakk

YGRFKVKMDSVTETAEYVIRSFQLSedGKETGQRSITQFHFLGWPDH-GQPDYPSPMMCLIKRVRhLtskMNHRANIVVHCSAGVGRTGTYIVIDAMLDM
|  . |.     |  .| | ...|    |.   . .| ...  |     .  |  |.. .. . . |    |    .||.||.||||.||..|||..|. 
yqdltvehslekeendyqiitlelk..fknesahnvtlyyykkwnintnnkpylkplfgilaknq.l...engnrPlvvacsdGvGrsGtflvidsqler

MKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.|.|  .||..|.  ||.|| .||..  .| .||  | |
aktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 13-248 7e-49 161.3 In-house 32-293 (297) alignment
Range on Protein: 13-248
Range on HMM: 32-293/297.0
PNKDKNRYINIIAYDHTRVKLKptDGIEGSDYINASYVNGYQ--SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN--KGV
    |||| .|.|.| |||||.   .| ..||||| ||   .  .. |.| |||| ..|..|||....| .  .|||..|  |||.|||  |||.  .. 
sslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

IKYGRFKVKMDSVTET--AEYVIRSFQLSEDgkeTGQRSITQFHFLGWPDHGQP----D---Y---------PSPM-MCLIK--------RVRHLTSKMN
 | | . |.  | |       ..  .||      . .| ..   ||.||||| |    |   .           || ..|..        ..  | ..| 
lkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemp

HRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
  | ..|||||||||.|  .  |..|.......  |.  ... .|.||  |||.. |. ... | |.
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 13-248 2.9e-46 152.4 In-house 53-281 (290) alignment
Range on Protein: 13-248
Range on HMM: 53-281/290.0
PNK--DKNRYINIIAYDHTRVKLKptDGIEGsDYINASYVNGYQSPdkFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GV
 |    |||| ...  | ||| ||  || .| ||. | ||.| ...  || .||.  .|  |.|||. . . ..|||| . ||||| ||.||.|.|   |
kntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

IKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDypsPMMCLIKRVRHLtskMNHRANIVVHCSAGVGRTGTYIVIDAMLD
. .| . |     ..  . .|.      | ..  .  .  ..   |||.  .      . |.. .| |    .    .|||||||.|||||.. |.. |.
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksval...stlallrtlril...rkasGpvvvhcsaGiGrtGtfvaievglq

MMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.. . |..|. . .  .|. | . ||  .||. .  .||.
illdGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_CG42327_pd Subfamily CG42327 13-175 1.1e-30 101.4 In-house 27-192 (319) alignment
Range on Protein: 13-175
Range on HMM: 27-192/319.0
PNKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQ-SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG----
  |||.|.||..   .||| |.     . . |..|||| ||. .|  .|||| . ...  ||||..|| .  .|| ||.  | | ..|..|.| |     
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

VIKYGRFKVKMDSVTETAEYVIRSFQLSEDGKETgQRSITQFHFlGWPDHGQPDYPSPMMCLIKRVRH
   || ..| .       .|.| .. | .  ||   | .| . .  |.. . |  ........ .|| 
tslyGdilvtlkgrevkdryaistlllkrvdkee.srelthywy.kwleaevPaeeaaliamllevrs

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 13-98 3.6e-13 43.7 In-house 33-117 (332) alignment
Range on Protein: 13-98
Range on HMM: 33-117/332.0
PNKDKNRYINIIAYDHTRVKLKPTDGIEgsDYINASYVNGYQSPDKFIAAQGPK-DNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDK
 | | ||   . ..||.||.| | || .  |. |||.|.||     .| || |  | |   ||||. | . | |...    |  | |
nnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_PTPRK_pd Subfamily PTPRK 14-286 7e-89 292.8 In-house 43-312 (314) alignment
Range on Protein: 14-286
Range on HMM: 43-312/314.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIkYGR
|..|||. .|.|||..||.|...||   ||||||.....|. | .||..|||...|..||||.....||..|||||. .| |. ||..|||... . || 
nreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygd

FKVKMDSVTETAEYVIRSFQLSE-DGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmnHRANIVVHCSAGVGRTGTYIVIDAMLDMMKH
.||.. ...  ||.|.| |....   .  ..| . ||.|||||||. | .   .. |..|| . . .  .  .|||||||| |||||.|.|| .|||...
ikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmier

EKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLsNKSDFDDDLTKLEVEF
|. ||..| ....|...  .|.   || ||. ..||  | |.. . . .| | | .  .. | . . ..|. ||
egvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyles.irldpqtnssqlkeef

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 14-262 2.7e-88 291.1 In-house 46-295 (305) alignment
Range on Protein: 14-262
Range on HMM: 46-295/305.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVI--KY
|| |||. .|. .|. |..|....  . |||||||||.||.. .|.|.|||| .||..||||.|.|.  |||||||| .|.||||| ||||..     ..
nkaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkef

GRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmNHRANIVVHCSAGVGRTGTYIVIDAMLDMMK
|.|.|.. | .....|..| ...| . ..  .|...|...  ||||| |.... .. |||||..  .| ..   ..|||||||||||..|..| .|. .|
gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkgvpllVhCsagvgRtGvfiavdialerlk

HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDF
.|..||... .. .|..|  .||.  || |.| || |.   |. .. . ..
kEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl

Y_phosphatase Protein-tyrosine phosphatase 14-248 1e-86 285.5 Pfam-A 1-235 (235) alignment
Range on Protein: 14-248
Range on HMM: 1-235/235.0
NKDKNRYINIIAYDHTRVKLkpTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP--NKGVIKY
||.|||| .|..||.|||||  ..  . ||||||.||.||... ||||.||| ..|.||||||.|......|||||.. | |. ||.||||  ...  .|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GRFKVKMD-SVT-ETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTskMNHRANIVVHCSAGVGRTGTYIVIDAMLDM
|..||..  ... ...||..| ..|.....|. .|...|.|. .||||| |. |.... ||..|.. .   ......|||||||||||||....|..|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

MKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
...|..||.....  .|.||. .|||. || |...|.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 14-248 1e-86 285.5 In-house 1-235 (235) alignment
Range on Protein: 14-248
Range on HMM: 1-235/235.0
NKDKNRYINIIAYDHTRVKLkpTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWP--NKGVIKY
||.|||| .|..||.|||||  ..  . ||||||.||.||... ||||.||| ..|.||||||.|......|||||.. | |. ||.||||  ...  .|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GRFKVKMD-SVT-ETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTskMNHRANIVVHCSAGVGRTGTYIVIDAMLDM
|..||..  ... ...||..| ..|.....|. .|...|.|. .||||| |. |.... ||..|.. .   ......|||||||||||||....|..|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

MKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
...|..||.....  .|.||. .|||. || |...|.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 14-274 1e-74 246.5 In-house 43-300 (515) alignment
Range on Protein: 14-274
Range on HMM: 43-300/515.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN--KGVIKY
|  |||| ||. || .||||.  .    |||.||||......   .||.|||.. ...||||.....| .||.|.||  |. | ||..|||.     .|.
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GRFKVKMDSVTETAEYVIRSFQLSEDGKetgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHraNIVVHCSAGVGRTGTYIVIDAMLDMMK
| .||.. |.   .. ..| ...  . .    | .||||| .|||.| |   | .. ||| |.  .....|   ...|||||||||| .| || ..  .|
Gsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyth..pliihcsaGvGrtGvvisidsvvahak

HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDFPAYYQQLSNKSD
  . ||..||.. |||.|  |||   || ||. |.||. |.  . . .  |  . |.|    |
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgd

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 14-248 3.8e-70 230.8 In-house 3-237 (237) alignment
Range on Protein: 14-248
Range on HMM: 3-237/237.0
NKDKNRYINIIAYDHTRVKLKPTDGieGSDYINASYVNGYQ-SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG-VIKY
|| |||| ||.||||.|| || . .  |||||||.|..|.. .| |.|||||| ... .|||.|.|. .|| |||||  ||  . || .|||.      |
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMK
| . | .    | ..| .||. ||. ..  . | | |..|  |||.| |.. . .. . |.. . . .... .  ..|||||||||| ..||||||   |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
 .| |||||... | ..|  ..|.  || ||| ..||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 14-251 2.9e-68 225.2 In-house 51-285 (297) alignment
Range on Protein: 14-251
Range on HMM: 51-285/297.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSpdKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKdKCSQYWPNKGVIKYGR
| .|.|| ||. ||  ||||. ..    |||.|||.|.|..   ..|. | |...|..|||.|..... ||||||..  |  | || .||..||| ..| 
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGd

FKVKMDSVTETAEYVIRSFQLSEdGKETGQRSITQFHFLGWPDHGQPD--YPSPMMCLIKRVRHLTSKMNHRaNIVVHCSAGVGRTGTYIVIDAMLDMMK
  |.. ||.|   .. |...... ||   .| . |..|. |||.  .     | .. ||. ||.  |. ..   ..|||.||||||| .. || ..  .|
vsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeak

HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
.||.|||..... .||.|  |||   || |.. |.||  |
rekevdifglvkklrqerpylvqtkeqykfvyvavleall

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 14-248 8.8e-67 219.7 In-house 7-238 (239) alignment
Range on Protein: 14-248
Range on HMM: 7-238/239.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQ-SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKgVIKYG
|| |||| ||..|||.|| |.       ||||||||.  |. ||  .||.||    .  |||||.|.     |||||  ||  | || ||||.    || 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

RFKVKMDSVTETAEYVIRSFQLSEDGKeTGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKH
 ..| .      |.|.||.| .|. |. | .| . |.||  |||.| |.| . .. | ... .    .      |.||||||||||...||||||   |.
nlrvtlrktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidamlrqakk

EKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.| |||.|... ||..|  .||.  || |||.|.||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 14-248 1.3e-66 219.2 In-house 8-239 (239) alignment
Range on Protein: 14-248
Range on HMM: 8-239/239.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQ-SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKgVIKYG
|| |||| ||..|||.|| |.       ||||||||.  |. ||  .||.||    .  |||||.|.     |||||  ||  | || ||||.    || 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

RFKVKMDSVTETAEYVIRSFQLSEDGKeTGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKH
 ..| .      |.|.||.| .|. |. | .| . |.||  |||.| |.| . .. | ... .    .      |.||||||||||...||||||   |.
nlrvtlrktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidamlrqakk

EKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.| |||.|... ||..|  .||.  || |||.|.||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 14-247 2.7e-65 215.1 In-house 20-261 (270) alignment
Range on Protein: 14-247
Range on HMM: 20-261/270.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQS-PDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK----GV
.|  ||| .|.   .|||.|.. .  . . |||| ||.|... . |.|||.||...||..||||||| . ..|||.|.  |.|..||..|||..      
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

IKYGRFKVKMDSVTETAEYVIRSFQLSEDGKEtgqRSITQFHFLGWPDHGQPDYPS------PMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIV
...|  ||   | . .  |...  .| |.|.|   | .. |..  ||||| |  .        .. ... ||. ......   ..|||||||||||| |.
ledgkikvlalseekeegyiltrlrleekgee...rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
.| .. .....|.||. . |...|..|  |||  .|| |.. |..
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv

subfamily_CG7180_pd Subfamily CG7180 14-251 4.1e-64 211.1 In-house 42-291 (296) alignment
Range on Protein: 14-251
Range on HMM: 42-291/296.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKdKCSQYWPNKGVIKYGR
|..|||..... ||..|| |.  || | ||||||.||...  . ..|  ..||..|...|||.... ..|..|.|||  .  | .. .|||||.  .|| 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

FKVKMDSVTETAEYVIRSFQLSED---------GKETGQRSITQFHFLGWPD-HGQPDYPSPMMCLIKRVRHLTSKM---NHRANIVVHCSAGVGRTGTY
. |.. .. . |. .|| |.|            . .. .| ...|..  |.  .  |   . .. |..||| .  |.   .... .||..| |..|.| |
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

IVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
. ||| |.....|..||.....  .|..|. ||..  .| .|   |||  |
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

subfamily_PTPN23_pd Subfamily PTPN23 14-248 4.8e-58 191.3 In-house 43-278 (288) alignment
Range on Protein: 14-248
Range on HMM: 43-278/288.0
NKDKNRYINIIAYDHTRVKLKptdgIEGSDYINASYVNGYQ--SPdKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GVI
. .|||. .|. |||.||||.     .  ||||||.|..    .| .|||.|.|...|| |||.|..|   |.||||..  | || |...|||..     
yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

KYGRFKVKMDSVTETAEYVIRSFQLSEDGKETgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRH--LTSKMNHRANIVVHCSAGVGRTGTYIVI-DAM
|.| ..| . ||.|| ..| | ..|.  ....  .|..  ..  ||..| |. |. .. ... |..   . . . .. .||||||||||||.. ..  |.
kfgdlsvtlksvretethvervlkletldada.vksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

LDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
 .. |..  .|| . .. .|.||   ||   |. |   | ||
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

0041856 (Phosphotyrosine protein) phosphatases II 14-254 6.1e-55 180.9 In-house 1-175 (182) alignment
Range on Protein: 14-254
Range on HMM: 1-175/182.0
NKDKNRYINIIAYDHTRvklkptdgieGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTkciedgkdkCSQYWPnkgvikygr
|.||||| .|. |||.|          ..|||||... |.. ...|||.||| ..|..||.||..|....|||.||         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

fkvkmdsvtetaeyvirsfqlsedgkETGQRSITQFHFLGWPDHGQPDyPSPMMCLIKRVRHltskmnHRANIVVHCSAGVGRTGTYIVIDAMLDMmkhe
                          |  .| ..|...|.||||| || .. .  .|..|..      .  ...||||||||||||..... |. .    
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....

kQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGH
 .|.... .. .|..|.  |..  ||||...||||..|.. 
.gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 14-247 4.6e-54 178.1 In-house 38-274 (287) alignment
Range on Protein: 14-247
Range on HMM: 38-274/287.0
NKDKNRYINIIAYDHTRVKLKpTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGV-IKYG
.  |||| ... .|.||| |  ..|  ||||||| || .|.  ..|||||||   |. ||||...| . ......|. .|... || .|||.. | .. |
avkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

RFKVK-MDSVTETAEYVIRSFQLSEDgkETG-QRSITQFHFLGWPDHGQPDYPSPMMCLIKRV-RH--LTSKMNHRANIVVHCSAGVGRTGTYIVIDAML
 . |  .|      || .|...| .   ||   | . |...| |||.. .     .. ..  | .|  |. . .    .|||...|.||.|... . ...
GysvvlldydikePeygvralrlidl..etrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

DMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
....   .||. . .  .|..|..|||. ||. ..  || 
srledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 14-246 2.4e-53 175.8 In-house 40-289 (301) alignment
Range on Protein: 14-246
Range on HMM: 40-289/301.0
NKDKNRYINIIAYDHTRVKLKPTDG--IEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG--VI
||  ||. ||  ||. |. |||.    .   .||||||..||..  |||||||| ..|| ||||.||..  ..|||.|.  |. |.|| |||||      
nkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaese

KYGRFKVKMDSVTETAEYVIRSFQLS-EDGKE-------------TGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhRANIVVHCSAGVG
..| |.|.. . .   ..|||....  .|| .                ....|..   ||..|    |  ..  |  | | . |..  . .|||||..|.
efgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkig.ggpvvVHCSdtVs

RTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMAL
|.|.|. ..  |.  | |  ||... .. .|...   |.   || .|. ..
rsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi

subfamily_ptpA1_pd Subfamily ptpA1 14-217 1.7e-45 150.5 In-house 47-264 (418) alignment
Range on Protein: 14-217
Range on HMM: 47-264/418.0
NKDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYqSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK-------
|  |||| ||.  .||||.||  .  |||||||| |..|   | .||..|||  ||. |||||.||  |  ||||..  |. . || .|||..       
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

----GVIKYGRFKVKMDSVTETAE--YVIRSFQLSEDGKetgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRV----RHLTSKMNHRANIVVHCSAGVGR
    |   .| . |..  | .  |   . |  .|. .|.    | |||... |||||  ||.  |.  |.. .     ..    ..   |.|||||||||
iygngnevfgtysvelveviqdpereiitrnirltfege...trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGTYIVIDAMLDMMKHE-KQVD
|||.     |.  . |  ||.|
tgtfctavimmkkldhyfkqld

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 14-251 1.1e-41 137.5 In-house 55-290 (305) alignment
Range on Protein: 14-251
Range on HMM: 55-290/305.0
NKDKNRYINIIAYDHTRVKLKPTDgieGSDYINASYVNGYQSPDK-FIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN----KGV
.. |||| .. . |.. |||.       |||| | ||     |.| ||.|||| |.|...|| |. . .   |||| | .| || ||.||||     |  
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

IKYGRFKVKM---DSVTETAEYVIRSFQLSEDGKETgqRSITQFHFLGWPDHGQPDypspmmCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDA
.| |    ..     .   ||  |  ..|.  |...   |. ....  ||| | |       | .  .  |..    .  ||||||||.||||| . |. 
lksgivvenvsgskpmerdaeiqitllnltysgdqk..msvrhlqwtewpdrgvpp......ckltslellsairgskvpivvhcsagigrtgtivaiey

MLDMMKHEKQVD-IYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHL
.|. .  .|..  . .... .|.||   .|. |||.|||  .|.  |
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 14-248 4.1e-41 135.7 In-house 48-285 (305) alignment
Range on Protein: 14-248
Range on HMM: 48-285/305.0
NKDKNRYINIIAYDHTRVKLKPTdgiEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GVIKY
...|||| ..   |. ||||...      .|| | ||     | .|| .| | ..|  ||| | .. .  .| || . .| |  ||..|.. |   |...
eagknrykdvgcldnnrvklegp...wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

G----RFKVKMDSV-----TETAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLtskmnhRANIVVHCSAGVGRTGTYIV
     .  ||..|      .. |. ...  .|  .|  . .| .|..|.  ||| | |     .. |... | .      .  ||||||||.||||. ..
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps......kgpivvhcsagigrtgsvvm

IDAMLDMMKHEKQVDI-YNFIHDIRQQRNTLVQSFVQYFFIHMALLE
.. .|| .   ....     .  ||.|||  .|.  ||.|.|  .|.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 14-247 1.2e-36 120.9 In-house 52-287 (310) alignment
Range on Protein: 14-247
Range on HMM: 52-287/310.0
NKDKNRYINIIAYDHTRVKLKpTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIK-YG
.  |||| ...  | .|||||  |     ||| | ||.     . || .||| . |. ||||||..  . .|..| |  |.|. ||  |||  || . ||
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

RFKVK-MDSVTETA-------EYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDYpspmMCLIKRVRhLTSKMNHrANIVVHCSAGVGRTGTYIVID
  .|  .   .|          .|     . |.  .  .  ..  ..  ||| | ||      |     | | ... |    |||||||..|... . ..
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde....kchtvpqr.llaqvrh.gpcvvhcsagkdrlyvvvalk

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
  .| ... ..||. . . .....|   .|. .|| .|..  .
lkidkldrglkvdaeevktellksraiciqtelqyliidrvri

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 14-247 1.6e-24 80.9 In-house 51-282 (302) alignment
Range on Protein: 14-247
Range on HMM: 51-282/302.0
NKDKNRYINIIAYDHTRVKLKptdgIEGSDYINASYVNGYQSPDKFIAAQGPKDNTL---EDFWRMIWEYNCSTIVMLTKCIEDGKdKCSQYWP--NKGV
| .||.  .. ..|...|||.     |  .|.||| |.  .   . | || || ..    |.||||... .. ..|.| .  |  |   |...|      
nlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

IKYGRFKVKMDSVTETAEYViRSFQL---SEDGKETGQRSITQFHFlgWPDHGQPDYpspMMCLIKRVRHL-TSKMNHRANIVVHCSAGVGRTGTYIVID
 .||.. |    | .. | .   . .    |.  ..   ... ...  |...  |.    .  ||| . .. ..|..  .|.|.    |.|| |. ..  
keygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltn..Wkqkkvpvk...yaeliktaakvfakkikadentvivSknGaGRagafltla

AMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
. .. ....|.. | . .. ||.|| . |.|. || ....|||
vaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 14-64 8.6e-11 35.9 In-house 48-95 (95) alignment
Range on Protein: 14-64
Range on HMM: 48-95/95.0
NKDKNRYINIIAYDHTRVKLKPTdgiEGSDYINASYVNGYQSPDKFIAAQG
|  |||..||. || ||| |        |||||| .|.||   . .|||||
nipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaqg

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 14-94 1.2e-08 28.9 In-house 37-122 (347) alignment
Range on Protein: 14-94
Range on HMM: 37-122/347.0
NKDKNRYINIIAYDHTRVKLKPTDGIEG-----SDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIED
. .|||  .    | ||| | | .   .       |||||...  ..  ..| .| |  .|. |||.|.   . . .| . . |.|
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 15-262 7.2e-67 220.7 In-house 49-291 (439) alignment
Range on Protein: 15-262
Range on HMM: 49-291/439.0
KDKNRYINIIAYDHTRVKLKPTDGIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKdkcsqYWPNKGVIKYGRF
. |||| .. |.||||| |. . |.  | |||| |..||  .. .||.||||..| .||||...| ...||||||. .|  |     ||| .. . ||  
qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdi

KVKMDSVTETAEYVIRSFQLSEDG-KETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKHE
 |..|   |  .|||| |.. ..  .   .|.. |||.. |||.  |   | .. ... .     | .    .||||||||||||| | .|  |. .| |
avrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdialeqlkle

KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLFGHSDVAMPDF
..|||   .. .|.||. .||...|| ||. |.||.  .|   |.. .|
nkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 15-252 6e-39 128.8 In-house 44-273 (288) alignment
Range on Protein: 15-252
Range on HMM: 44-273/288.0
KDKNRYINIIAYDHTRVKLKptdgIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG--VIKYG
  ..|| |.   | |||||.     .   ||.|  |   . . ..| || | . |.| .|.|. | .   ||||.. .| ||.|  .|.| |    ...|
ptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarig

RFKVKMDSVTETAEYVIRSFQLsEDGKETGQRS-ITQFHFLGWPDHGQPDYPSPMMCLIKRVrhltskMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMK
|.   .    .  . ...   |    ||. ..  . . |.| |.|.| |.   . . |....       ...  ||||.||||||||| |.|  .|....
rlctvvkkkradidklvkvsll.riskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslr

HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEEHLF
 . .. | ....  |..|   .|.  || ..|  .||| |.
lddflgirsllaklreerfkaiqtemqylyvhrcvleelll

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 15-248 4.2e-35 116.0 In-house 44-274 (312) alignment
Range on Protein: 15-248
Range on HMM: 44-274/312.0
KDKNRYINIIAYDHTRVKLKPTDgiegSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN-KGVIKYGR
|| ||| ||  .|  |  |   .      || | .|.    |..|...||| .||   ||..     ...|..|.  .||| .||..|  .  | ..   
kdlnrypniqcwdrgrftlagde....nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

FKVKMDSVTET-----AEYVIRSFQLSEDGKETGQRS-ITQFHFLGWPDHGQPDYPSPMMCLIKRVRhltskmNHRANIVVHCSAGVGRTGTYIVIDAML
 .|  ...||      .   |    |    | ||| | . .. .  ||||| ||     . |.  |.      . .  .. ||||||||||| ..|..|.
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk......kdkkpviahcsagvgrtgtlaliesmi

DMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
  ..| .. .. .    .|..|   |. | || .   ..||
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 16-137 4.3e-26 86.5 In-house 49-185 (350) alignment
Range on Protein: 16-137
Range on HMM: 49-185/350.0
DKNRYINIIAYDHTRVKLK----PTDGI----EGSDYINASYVNGY-----QSPD-KFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQ
 |||| ||. |.|.|||||    ..|..    ...|||||.|..       . || |.||.|.|  .|..||...| . .   |..||. .| . .|| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPNKGVIK-YGRFKVKMDSVTETAEYVIRSFQLSED
||.. .. .   ... | ...... . ...|... ..
YWqegsydditvklaskwenimgindsslysadvkke

subfamily_eak_pd Subfamily eak 16-249 2.6e-23 77.0 In-house 54-304 (332) alignment
Range on Protein: 16-249
Range on HMM: 54-304/332.0
DKNrYINIIAYDHTRVKLKPTDgIEGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKG--VIKYGR
..|  ..|. ||.  |.| ..   .   ||||| ..  .   |.| .  .... .  ||.|. | .  .||.| . .| . .|  .|.|.|.  ..|.| 
nrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGi

FKVKMDSVTETAEYVIRSFQLSEdGKETGQrsITQFHFLGWPDHGQPDYPSPMmCLIKRVR-------------HLTS---KMNHR---ANIVVHCSAGV
..|.  .  . . .  | ..||  | || .  .  ... || .   | |   .  | | ..              |.|   |  |       .. .. | 
ldverkefvkrniletrllelsk.Gnethr..vlhykvfGwtettlpkyedfl.alrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGs

GRTGTYIVIDAMLDMMKHEK--QVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
 |.|...||| .. ..   |     . ..|  ....|.  |    |. ||. ..|. 
araGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 16-122 7.4e-15 49.1 In-house 50-169 (349) alignment
Range on Protein: 16-122
Range on HMM: 50-169/349.0
DKNRYINIIAYDHTRVKLK----PTDGIEG----------SDYINASYVNGYQ--SPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKC
 |||| .|. |.|.|||||    .. .|.            ||||| |..  .     |.|| | |   |..||...|   .   .. |..  | . .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

SQYWPNKgviKYGRFKVKMDSVT
 .|| .    .|  ..||.    
diywqel...sysnitvklqnss

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 25-247 1.3e-20 68.8 In-house 29-256 (290) alignment
Range on Protein: 25-247
Range on HMM: 29-256/290.0
AYDHTRVKLKPTDGIEGSDYINASYVNgYQSPDKFIAAQGPKDN-------TLEDFWRMIWEYNCSTIVMLTKCIEDGKD----KCSQYWPNK--GVIKY
   .||| ||       .||| |..|  . .  ..|. | |. .       |.|.|| |. . .   .||| .  |  ..     |..| |..  . .|.
LveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf

GRFKVKMDSVTETAEYVIRSFQLSEDGKEtgQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVrhltskMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMK
. ..||  |  .  .  .|   .  |..|  .  .|   . || .   .. .  .. ||. |      ..... ..|||  |. |  .   |.    .. 
kgltvkCkskekeddvetRelvvkfddee..eftvtHsllkgWnklnvqedtktllsliqkv......kasktpvivHcvdGiSrsAalaaiilgyQkia

-HEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALL
  ...| . . ....|.||.....|  .. |.  ...
etsgsvkledvlkalrkqralaitsalelafvdagiv

0044763 (Phosphotyrosine protein) phosphatases II 26-246 2.4e-37 123.6 In-house 2-167 (178) alignment
Range on Protein: 26-246
Range on HMM: 2-167/178.0
YDHTRVKLKPTDGIEGSDYINASYVNGYqspdKFIAAQGPkdntlEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVikygrfkvkmdsvteta
.|.|||.| .  |.|.|||||||.. ..     ......|     .|......|.....||.||. .| |. || .||| .                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

eyvirsfqlsedgketgqrsiTQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmNHRANIVVHCSAGVGRTGTYIVIDAMLDMmkhekQVDIYNFIHDI
                      |......|||| || .. .. ... .... .  ..  ...|||||||||.|| .... |. .     ...... |. .
.....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielv

RQQRNtLVQSFVQYFFIHMAL
|..|.  |... |. ....  
rerRp.ivpnpgqlrqLyefe

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 26-158 2.3e-08 28.4 In-house 5-125 (130) alignment
Range on Protein: 26-158
Range on HMM: 5-125/130.0
YDHTRVKlkptdgieGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDgkDkcsQYWPNKGVIKYGRFKVKMDSVT-ET
.. .|..        | .|||||.|   .   ... .| |  .|  |||.|. |     .|.|    |.  |   .|||.   ...   .. . .   . 
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee..d...eywpdsePlewyeediivtltdrde

AEYVIRS-FQLSEDGKEtGQRSITQFHFLGWPDHG
 ...  | .. ..| .|  ....| |.   ||  |
fknikasnleiesdlne.shqaltmfqisnwpsdg

0046846 (Phosphotyrosine protein) phosphatases II 38-247 4.8e-43 142.2 In-house 8-170 (176) alignment
Range on Protein: 38-247
Range on HMM: 8-170/176.0
GIEGSDYINASYVNGYqspdKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNkgVIKYGRfkvkmdsvtetaeyvirsfqlsed
  ...|||||... |.    ..|| |||  .||.||..|..|......|.||...| |. || .|||   . |.|                         
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi........................

gketgqrsitQFHFLGWPDHGQPDYpSPMMCLIKRVRHLTSKMnhrANIVVHCSAGVGRTGTYIVIDamldMMKHEKQVDIYNFIHDIRQQRN-TLVQSF
          |...|.||||| ||. . .. |.. .|   ..     ...||||||.|||||.....    ....||...... .. .|.||    ||..
..........qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

VQYFFIHMALL
 || |.....|
eQyrflyefel

0051429 (Phosphotyrosine protein) phosphatases II 39-249 2.5e-53 176.7 In-house 1-224 (272) alignment
Range on Protein: 39-249
Range on HMM: 1-224/272.0
IEGSDYINASYVNGYQS---PDKFIAAQGPKDNTLEDFWRMiWEYNCSTIVMLTKCIEDGKDKCSQYWP------------NKGVIKYGRFKVKMDSVTE
.. |.||||..|.|| .   |.......|| ..| .||||. .|....|||.|... | |..||..|||                | ||.. |.. |.. 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

TAEYVIRSFQLSEDGKETGQRSITQFHFLGWPDHGQPDypSPMMCLIKRVRHltskmnhRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVD------
.  |..| ..|.   . .  | ....|...||||| |.  ...  |.. ...         ...||||||..||||..... .|  . .|  ||      
lldyilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--IYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
  ...... .|.||   ||.  || |...|||| 
lyleeaveelraqrpgavqteeqylflyeallel

0043147 (Phosphotyrosine protein) phosphatases II 40-244 1e-45 150.9 In-house 3-155 (172) alignment
Range on Protein: 40-244
Range on HMM: 3-155/172.0
EGSDYINASYVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCiedgkdkcsqywpnkgvikygrfkvkmdsvtetaeyvirsfqlsEDGK
||||||||||...|  ||.||| ||| .|||.|||||..|.....||.||..                                            .  .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

ETGQRSITQFHFLGWPDHGQPdYPSPMMCLIKRVRHLTsKMNHRANIVVHCSAGVGRTGTYIVIDAMLdmmkheKQVDIYNFIHDIRQQRNTLVQSFVQY
|  .|.. |...|.||||| |  .. .. ... ...|    .    ..|||||||||||| .... ||      ....... .. .|..|.  ||.. ||
ellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

FFIHM
 |...
rflyy

0036282 (Phosphotyrosine protein) phosphatases II 41-243 5.2e-48 158.3 In-house 1-163 (174) alignment
Range on Protein: 41-243
Range on HMM: 1-163/174.0
GSDYINASYVNGYQSPDKFIAAQGPKDntledFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNkgvikygrfkvkmdsvtetaeyvirsfqlsedGKE
||||||||.....  ....|| ||| .     ||.|..|....|.|||....|.|. || .|||                                  .|
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

TGQRSITQFHFLGWPDHGQPDYPSpMMCLIKRVRHLTSKmNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKhEKQVDIYNFIHDIRQQRNTLVQSFVQYF
   |.. |...|.||||| || .  .  ..|.|..  |. ..   ..|||||||||||| .... || ... |. ||...... .|.||   ||.. || 
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FIH
|..
fly

0051082 (Phosphotyrosine protein) phosphatases II 41-247 6.3e-38 125.1 In-house 2-150 (151) alignment
Range on Protein: 41-247
Range on HMM: 2-150/151.0
GSDYINASYVNGYqspdkFIAAQGPkdntLEDFWRMIWEYNCSTIVMLTKCIEDGkdKCSQYWPNKGvikygrfkvkmdsvtetaeyvirsfqlsedgke
 |||||.||| |.     ... .||    |.||.....|....|||.|..  | |  .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

tgqRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHltskmNHRANIVVHCSAGVGRTGTYIVIDAMLdMMkhekqVDIYNFIHDIRQQRNTLVQSFVQYF
   . ......|.|||.| |...  .. ... ...     .   ...||||||.||||| .... || ..     |...  ....|..|  .||.. |..
...ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqfl

FIHMALL
|...|||
fqlfall

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 44-244 1.1e-09 31.4 In-house 102-303 (346) alignment
Range on Protein: 44-244
Range on HMM: 102-303/346.0
YINASYVNGYQSPDKFIAAQGPK---DNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIKY-GRFKV---KMDSVTETAEYVIRSfqLSE
..   |.  .|   |.| || |.   .  .|||| ||.. .   . ..       .   | .  ..|  .| |.. .   . |   .  || |    | |
hlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytiev..lpe

dGKetGQRSITQFH-FLGWPDHGQPDYPSPMMCLIKRvrHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQS
 |.   .  | | |    |    ||    |.. .|..   |. |  . | . |    | ||. ..|     .. .    . .|.. ...|.|||   |.|
.gn..sdsvicqvhhhapwkhlqqppktlpiikmihq..flsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggves

FVQYFFIHM
| ||  |. 
faqyasiya

0049260 (Phosphotyrosine protein) phosphatases II 49-243 1.2e-44 146.9 In-house 1-143 (152) alignment
Range on Protein: 49-243
Range on HMM: 1-143/152.0
YVNGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWpnkgvikygrfkvkmdsvtetaeyvirsfqlsedgketgqrsitQ
...||  | .|||.||| .|||.|||||..|....||||||.. |.||.|| ||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

FHFLGWPDHGQPDYPSPMMCLIKRVRHLtsKMNHRANIVVHCSAGVGRTGTYIVIDAMLdmmkheKQVDIYNFIHDIRQQRNTLVQSFVQYFFIH
...| ||||| || .  .. |.. ...|  . .   ...||||||||||||..... ||      ..|......  .|..|.  |... |..|..
ylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 51-123 6.2e-13 42.9 In-house 230-300 (440) alignment
Range on Protein: 51-123
Range on HMM: 230-300/440.0
NGYQSPDKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCiEDgkDKCSQYWP-NKGVIKYGRFKVKMDSVTE
.||   . |||.| | | |. ||||.. .|. |||.|| .  .|    || ||| |   . .| | |      .
egyskknafiatqmpldstvldfwrlvhdyristiimlnql.nd..ktcsiywpvntrsvtfgpftvghkgsen

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 57-243 2.1e-23 77.5 In-house 5-197 (199) alignment
Range on Protein: 57-243
Range on HMM: 5-197/199.0
DKFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN--KGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGK-ETGQRSITQFHFLG
 ..||.| |  .|. |||.|.||     |||.     . .   . |||    |. ||| . |   ..|  ..|.| .. |...       | |... |  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGQPDYpSPMMCLIKRVRHLTSKMN--HRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEK--QVDIYNFIHDIRQQRNTLVQSFVQYFFIH
| ..  |.  . .. ..   | .. | .  . | ..|||| | | || .. .|  .   .  |   ||...  . .|| |  .. |. .| ||.
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 58-243 2.4e-23 77.4 In-house 5-196 (198) alignment
Range on Protein: 58-243
Range on HMM: 5-196/198.0
KFIAAQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPN--KGVIKYGRFKVKMDSVTETAEYVIRSFQLSEDGK-ETGQRSITQFHFLGW
..||.| |  .|| |||.|.||     |||.     . .   . |||    |. ||| . |   ..|  ..|.| .. |...       | |... |  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGQPDYpSPMMCLIKRVRHLTSKMN--HRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEK--QVDIYNFIHDIRQQRNTLVQSFVQYFFIH
 ..  |.  . .. ..   | .. | .  . | ..|||| | | || .. .|  .   .  |   ||...  . .|| |  .. |. .| ||.
kekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 62-244 3.8e-30 99.4 In-house 96-282 (302) alignment
Range on Protein: 62-244
Range on HMM: 96-282/302.0
AQGPKDNTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNK--GVIKYGRFKVKMDSV-------TETAEYVIRSFQLSEDGKET-GQRSITQFHF
   || .||| .| .| .|| . .| |.. .||.. ||..|. .|  |..|.||. ||  ||       |.  .... . .. .. |..  ....  ..|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

LGWPDHGQPDYPSPMMCLIKRVRhltskmNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHM
 .||||| |. . . . ..|          .. |..|||||||||||| . |   ... ...|  |. . .  .|| |   ||.  |  .. .
sawpdhGapkeaytaldilkfce......sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 68-248 3.7e-22 73.6 In-house 39-219 (255) alignment
Range on Protein: 68-248
Range on HMM: 39-219/255.0
NTLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIKYGRFKVKMDSVTETAEYVIRSFQLS-EDGKETGQRSITQFHFLGWPDHGQPDYPSPM
 |.. |...|   . ...|||.   |.|..|||.|.| .   |    .|.. .   .|. |.|  ..  . |.    . .. ... ||...  |. .  .
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

MCLIKRVRHltSKmnhraNIVVHCSAGVGRTGTYIVIDAMLD-MMKH---E--KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLE
. ..| ||.  ||      .|||||.|.||. ...... .   |..        ..|  ......|..|.. ..  .|  |  . .|.
lnilkvvrd..sk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

subfamily_hpo-7_pd Subfamily hpo-7 69-269 4.2e-19 63.5 In-house 46-243 (263) alignment
Range on Protein: 69-269
Range on HMM: 46-243/263.0
TLEDFWRMIWEYNCSTIVMLTKCIEDGKDKCSQYWPNKGVIKYGRFKVKMDSVTETAEYVIRSFQLSE-DGKETGQRSITQFHFLGWPDHGQPDYPSPMM
|.. |...|   . ...|||.   |.|..|||.|.| .   |    .|.. .     . .... .| .  |.    . .... . ||... .|  .  ..
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

CLIKRVRHLtsKmnhraNIVVHCSAGVGRTGTYIVIDAMLD-MMKH---E--KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEehlFGHSDVAMPD
 ..| .|..  |     ..|||||.|.||.  . |.. .   |..        ..|  ......|..|.. ..  .|  |  . .|.   |   . |  .
nilkvarns..k.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd...fvlnnfakge

FPAYYQQL
  | ||..
leakyqei

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 98-235 7e-07 23.0 In-house 149-287 (332) alignment
Range on Protein: 98-235
Range on HMM: 149-287/332.0
KCSQYWPNKGVIKYgRFKVKMDSVTETAEYVIRSFQLSEDGKETGQRSItQFHFLGWPDHGQ-PDYPSPMMCLIKRVRHLTSKMNH--RANIVVHCSAGV
 | ..||.|.  |     . ...  . .|  ...|.|.   |.  ....  .||  | |  . |.|   | . ||     .||        |.. |..||
icrkfwpekrskkd.fpalsiqasddhsethmktfnltvtekkqdhqtv.lmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcatgv

GRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQS
 .   .  || ..  .  |..| . . .  |. ||   ...
ekcaisatidiivsriteehrvgfketmsaikmqrfgcfrt

0048076 (Phosphotyrosine protein) phosphatases II 136-247 2.8e-23 77.6 In-house 37-140 (145) alignment
Range on Protein: 136-247
Range on HMM: 37-140/145.0
EDGKETGQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKmnhRANIVVHCSAGVGRTGTYIVIDAMLDmmkhEKqVDIYNFIHDIRQQRNTLVQS
 . .|   | ..|...|.||||| || .. .. ... .... ..     ...||||||||||||..... ||     .. |.... .. .|.||   |..
tselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpn

FVQYFFIHMALL
. |. |.....|
pgqlrflyefel

PTEN_1 138-200 1.7e-09 32.8 In-house 87-147 (196) alignment
Range on Protein: 138-200
Range on HMM: 87-147/196.0
GKETGQRSITQFHfLGWPDHGQPDyPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTY
 .|  .. ... | ....||| |.  | ... .|.. .  .. ... ...||| ||.||.|| 
leeffksgveylh.fpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtv

0048179 (Phosphotyrosine protein) phosphatases II 142-244 7.2e-23 76.3 In-house 45-139 (144) alignment
Range on Protein: 142-244
Range on HMM: 45-139/144.0
GQRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSkmnHRANIVVHCSAGVGRTGTYIVIDAMLdmmkHEKqVDIYNFIHDIRQQRNTLVQSFVQYFF
  | ..|...|.||||| ||... .  ... .... .   .  ...||||||||||||..... |.    ... ..... .. .|..|   |... |. |
leregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrf

IHM
...
Lle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 143-286 1.3e-25 84.7 In-house 88-229 (440) alignment
Range on Protein: 143-286
Range on HMM: 88-229/440.0
QRSITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNhRANIVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFI
 |.. |.|. ||||.| | . .|.. .|. | .   |    . ..||||||.||||  |..|..|   |.  |.||..||  .|..|  .||.  || |.
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HMALLEEHLFGHSDVAMPDFPAYYQQLSNKSDFDdDLTKLEVEF
| |.||  | | . .   |     .|.   . .  | . |. ||
heavlegllcgdtliledditerveqiqwpnpht.dksplqqef

subfamily_PTPDC1_pd Subfamily PTPDC1 144-238 8.7e-09 30.1 In-house 81-164 (182) alignment
Range on Protein: 144-238
Range on HMM: 81-164/182.0
RSITqFHFLGWPDHGQPdypsPMMCLIKRVRHLTSKMNHRaNIVVHCSAGVGRTGTYIviDAMldmMKHEKQVDIYNFIHDIRQQRNTLVQSFVQ
. |. .. .||.|.| .    ..  ..  |. ... ...  .. ||| || ||||  |   ..   . . |...  . |. .|..|   .|.  |
qgiy.vynfgwkDygva....sleriLdivkvvafalqeg.kvavhChaGlGrtGvli..acy...lvyakrltaekaiklvrskrpksiqtreq

PTPc_DSPc_SM00012 146-248 9.4e-35 114.4 In-house 2-105 (105) alignment
Range on Protein: 146-248
Range on HMM: 2-105/105.0
ITQFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLDMMKHE-KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHM
....|..|||||| |....... |.. |.. ..| ......|||||||||||||....| .|.....| |.|||..... .|.||...||.. ||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 148-247 6.2e-13 43.2 In-house 219-341 (350) alignment
Range on Protein: 148-247
Range on HMM: 219-341/350.0
QFHFLGWPDHGQPDYPSPMMCLIK--------RVRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMLD-------MMKHEKQVDIY--------NFIHD
|...  |.| .    |  ..  ..         . .. .. .. . |.||||||||||||.. .| .|        . |. ...|            .  
qlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivne

IRQQRNTLVQSFVQYFFIHMALL
.|.||  .||.  |. ||. |||
lrkqrismvqnldqfifiYeall

0038934 (Phosphotyrosine protein) phosphatases II 148-204 7.2e-08 27.8 In-house 81-136 (194) alignment
Range on Protein: 148-204
Range on HMM: 81-136/194.0
QFHFLGWPDHGQPDYPSPMMCLIKRVRHLTSKMNHrANIVVHCSAGVGRTGTYIVID
... | .||.| .   . ..  .. | . ... ..   ..||| ||.||||| ..  
eylklpfpddgtvPsleillrfldlvdeflnedpg.gvvaVHCkaGlgRtGtlvaaY

subfamily_CDKN3_pd Subfamily CDKN3 153-243 5e-06 20.2 In-house 106-189 (202) alignment
Range on Protein: 153-243
Range on HMM: 106-189/202.0
GWPDHGQPDypsPMMClIKRVRHLTSKMNHRANIVVHCSAGVGRTGtyIVIDAMLDMMkhEKQVDIYNFIHDIRQQRN-TLVQSFVQYFFIH
  .| . ||   .  | .| .  |.  ..   . .|||  |.||.   .||  .| ..  . ...  . | ..|. .    .|.  || ...
piadglvpd...iasc.lkileelrinlkayrktlvhcygglgrss..lviaclllyl..ddtiepkdaidklrdlkgsraiqtvkqynyls

subfamily_DSP23_pd Subfamily DSP23 154-238 2.8e-06 22.0 In-house 54-134 (148) alignment
Range on Protein: 154-238
Range on HMM: 54-134/148.0
WPDHGQPDYPSPMMCLIKRVRHLTSKMNHRANI-VVHCSAGVGRTGTYIVIdamlDMMKhEKQVDIYNFIHDIRQQRNTLVQSFVQ
.   . .||  | .  ...  ..  . .....   |||  | ||||| .       ..| |...   . | ..|..|   |... |
lvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlac....ylvk.erklaaaeaiaevrrlrpgsvetveq

subfamily_PTEN_pd Subfamily PTEN 161-239 1.3e-07 26.8 In-house 89-169 (184) alignment
Range on Protein: 161-239
Range on HMM: 89-169/184.0
DYPSPMMCLIK-RVRHLTSK--MNHRANIVVHCSAGVGRTGTYIVIdAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQY
|  .| . |..  |.....    ...  .|||| || ||||. ||   .| ... ||. .. .. . .| . .. |.   | 
DhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqr

subfamily_CDC14_pd Subfamily CDC14 168-239 7.8e-06 19.9 In-house 250-314 (328) alignment
Range on Protein: 168-239
Range on HMM: 250-314/328.0
CLIKRVRHLTSKMnhRANIVVHCSAGVGRTGTYIVIDamldMMKHEKqVDIYNFIHDIRQQRNTLVQSFVQY
 ..|.  ... |.  . .|.||| ||.||||| |       .||| . .   . |  .|  |   | .  | 
aivkkfleiaeka..eGaiavhCkaGLGrtGtLiacy....lmkhyr.ftaaeaiawlricrPGsvigpqqk

PTPc_motif_SM00404 173-228 3.2e-06 22.1 In-house 70-123 (140) alignment
Range on Protein: 173-228
Range on HMM: 70-123/140.0
VRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMldMMKHEKQVDIYNFIHDIRQQ
.. . .  . . ...||| ||| |..| |.   |  . .. .  . |.|... |..
ldfienaekkggkvlVHCqaGvSRSatliiaYlm..ryrqlslaeayefvkerRpi

DSPc Dual specificity phosphatase, catalytic domain 173-233 4.4e-06 21.6 Pfam-A 63-118 (133) alignment
Range on Protein: 173-233
Range on HMM: 63-118/133.0
VRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMldMMKHEKQVDIYNFIhdiRQQRNTLV
|. . . .. . ...||| ||. |..| |.   |  . |. .  . |.|.   ...|....
vefiekaeqkgkkvlVHCqaGisRSatliiaYlm..ktknlslneAyefv...kerrskis

DSPc Dual specificity phosphatase, catalytic domain 173-233 4.4e-06 21.6 In-house 63-118 (133) alignment
Range on Protein: 173-233
Range on HMM: 63-118/133.0
VRHLTSKMNHRANIVVHCSAGVGRTGTYIVIDAMldMMKHEKQVDIYNFIhdiRQQRNTLV
|. . . .. . ...||| ||. |..| |.   |  . |. .  . |.|.   ...|....
vefiekaeqkgkkvlVHCqaGisRSatliiaYlm..ktknlslneAyefv...kerrskis

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 181-248 7.8e-10 32.6 In-house 263-342 (349) alignment
Range on Protein: 181-248
Range on HMM: 263-342/349.0
NHRANIVVHCSAGVGRTGTYIVIDAMLDMM----KHEKQVDIYN--------FIHDIRQQRNTLVQSFVQYFFIHMALLE
.. . ..|||||| ||||... .| .|...    ..  .... .         .  .|.||  .|| . |. .|. |||.
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

subfamily_CG42327_pd Subfamily CG42327 182-246 3.8e-13 43.8 In-house 246-311 (319) alignment
Range on Protein: 182-246
Range on HMM: 246-311/319.0
HRANIVVHCSAGVGRTGTYIVIDAMLDMMKHE-KQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMAL
..  .||||| ||||||. |  |  .  ...  . ||| . .. .|..|   |..  || ||.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 186-249 1.5e-16 54.6 In-house 1-64 (69) alignment
Range on Protein: 186-249
Range on HMM: 1-64/69.0
IVVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
.|||||.| |||||.| |   .  .| || |||.| .  .|. |  .|   ..| ||| || | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 187-249 1.2e-15 51.6 In-house 1-63 (69) alignment
Range on Protein: 187-249
Range on HMM: 1-63/69.0
VVHCSAGVGRTGTYIVIDAMLDMMKHEKQVDIYNFIHDIRQQRNTLVQSFVQYFFIHMALLEE
|||||.| |||||.| |   .  .| || |||.| .  .|. |  .|    .| ||| || | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea

0050432 (Phosphotyrosine protein) phosphatases II 247-527 2.2e-86 285.3 In-house 9-300 (308) alignment
Range on Protein: 247-527
Range on HMM: 9-300/308.0
LEEHLFGHSDVAMPDFPAYYQQLSNKSDFDDDLTKLEVEFRRACKLGVnGTDQTFANIDQNKDKNRIGHILPFDKNVVKLerligEEFSDYINASFITGY
||  ||.. .. . ... ....| .. .  .||..|| ||.. ... .   . ..|.  .||||||  .|||.|.. |||     .| |||||||...||
lelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgy

--QRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLEID-ETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQ
   ... .||||||||||..|||||.||                   ||||||||.. ...| |...|||..| . .||.||| .|...   .. |....
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvth

YHFRGWPEVGVPESGIDLMRLVNKSHLHQkeqGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
.|. .||. |||.|  .|...... . ..   ...||||||||| ||||.|||| .|....|.| ..|||..|. ||.|||.|||.. |..|.| |..||
fhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley

LE
|.
lk

0051299 (Phosphotyrosine protein) phosphatases II 255-526 9.1e-85 279.9 In-house 3-286 (288) alignment
Range on Protein: 255-526
Range on HMM: 3-286/288.0
SDVAMPDFPAYYQQLSnksdfDDDLTKLEVEFRRACKLGVNgTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIA
 .. . ..  ....|       ..||.|. ||.. ..| ..  ....|.  .|..|||  .|||.|.. |||  | |.|.|||||||.|.||..|. .||
teisveellklvlkll.....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

TQGPLPNTIADFWRMIW------------------EMCAQYWPLeiDETEEQGDISVTLVEESEeDDDFTVRDIEISHA----HMKDIRKIRQYHFRGWP
||||||||..|||||.|                  | |||||||  ..... |||.|||..| . .||.||| .|...       .  |.....|. .||
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwp

EVGVPESGIDLMRLVNKSHLHQKeQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
. |||.|  .|...... . ... .|..|.||||||| ||||.|||| .|....|.| ..||...|. ||.|||.||| . |..|.| |..|||
dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_PTPRB_pd Subfamily PTPRB 256-531 2.7e-72 238.3 In-house 6-290 (293) alignment
Range on Protein: 256-531
Range on HMM: 6-290/293.0
DVAMPDFPAYYQQLSNKSDFdddltKLEVEFRRACKLGVNgTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIAT
.. . .| .........||.     ..  |. .  ..| . . ...|.  .|..|||   |||.|.. |||. | .|. ||||||..| ||. .. .|||
piklekfeehvkkmkadsdl.....rfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QGPLPNTIADFWRMIWEM------------------CAQYWPLEIDeTEEQGDISVTLVEESEeDDDFTVRDIEISHahMKDIRKIRQYHFRGWPEVGVP
|||||.|. |||||.||                   | .||| . . .   |||.||||.|.|  .|...|...|..   |..||.|||||  ||. |||
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadee.pvlyGdikvtlvaeee.ledwvirelkiek..ekeerkvrqyhftsWpdhgvP

ESGIDLMRLVNKSHL-HQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQST
|.   |...|.. .  ..|..  .||||||||| ||||.||||. |....||| ..|.| .|  ||..| ..||  .|. | .......|.....
ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 260-532 4.5e-68 224.7 In-house 8-296 (298) alignment
Range on Protein: 260-532
Range on HMM: 8-296/298.0
PDFPAYYQQLSNKSDfDDDLTKLEVEFRRACKLGV--NGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQG
.|. |  |.|....  . .||... ||.|  .     . . .. |. ..||.|||   |...|.  | ||.  ..| ||||||||. .|...| .||||.
edlkaalqklaavkk.kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqa

PLPNTIADFWRMIWE------------------MCAQYWPLEidETEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPES
||..|..|||||..|                   . .||| |  ..|. |.|.|.| . .||  |..|| ...|... .. |..|| ||  ||. |||| 
PltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvslls.keefadlivrklkvskkkeekerevrqlhftsWpdkgvpen

GIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTE
   .. |..| . .|.. | ||..|.|||| ||.| |||.. .. |...|...||||.|. ||..||..||  .|..|.|.|. |.|.  ..|
atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde

0045450 (Phosphotyrosine protein) phosphatases II 261-527 3.8e-77 255.3 In-house 8-305 (307) alignment
Range on Protein: 261-527
Range on HMM: 8-305/307.0
DFPAYYQQLSNKSDFDDDLTKLEVEFRRACKLGVN-GTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGE-EFSDYINASFI--------TGYQRKN
  .|..  |  . .  |.||.|. ||.. ... |    . ..|.  .||||||. .|||.| . |||  | |. | |||||||..         || .|.
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

MYIATQGPLPNTIADFWRMIWEM------------------CAQYWPLEiDETEEQGDISVTLVEESEeDDDFTVRDIEISHA-HMKDIRKIRQYHFRGW
 .||||||||.|..|||||.||                   ||||||.| .|. . |.. |||..|.. .|..||| .|...    .  |.....|. ||
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgw

PEVGVPESGIDLMRLVNKSHLHQKEQ-GPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESM---IDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
|. |||.|  .| ..... . ...|  ...|..|||||| ||||.|||. ......|.| .   .|....|. ||.|||..|| . |..|.| |. |.| 
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll





subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 265-526 5.7e-151 497.3 In-house 19-292 (319) alignment
Range on Protein: 265-526
Range on HMM: 19-292/319.0
YYQQLSNKSDFDDDLTKLEVEFRRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIA
|||||||||||||||||||||||||||||||..||||||.|||||||||..||.||||||||||||||||||||||||.||||||..|||.||||.||.|
yyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntla

DFWRMIWE------------MCAQYWPLEIDETEEQGDISVTLVEESEEdddFTVRDIEISH-AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNK-S
||||||||            .|.|||||.|...||.....|..|||..|   ..|||||.|. ...||||||.|.||.|||.||||....||||||.| .
dfWrmiweyncstivlltkdkcsqywplkivikeerfkvkvdsveetae...yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvr

HLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE-YL
||..||.....||||||||.|||||.|.|.||..||.||...||...||.|||||...||||.|.||.|||..| .|
hltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_PTPN23_pd Subfamily PTPN23 268-528 1.2e-54 180.1 In-house 10-282 (288) alignment
Range on Protein: 268-528
Range on HMM: 10-282/288.0
QLSNKSDFDDDLTKLEVEFRRAcklgvnGTDQTFANIDQNKDKNRIGHILPFDKNVVKLErligEEFSDYINASFITGYQRK-NMYIATQGPLPNTIADF
.|..|. .|    .|| .  .         ... |    . .|||   |||.|.| |||.    ..  |||||||. .       .||||.||..|..||
mldgktaldkkfkeleqkqdke......arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WRMIWE------------------MCAQYWPLEIDETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVN
|.|..|                   ...||| . .||.. ||.|||| .. |  . .  |...... . . .....  ..  |||.|||.|  .|.....
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre.tethvervlkletldadavksvshlqltsWpelGvPasPetllqfld

KS---HLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMS-RMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
.    . .....  .|.|||||||.||||||  .   .    ... ..|. | |. ||.|| .|||. .|.||.|.|..|. ..
evesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

0039614 (Phosphotyrosine protein) phosphatases II 269-527 1.1e-76 253.4 In-house 21-290 (297) alignment
Range on Protein: 269-527
Range on HMM: 21-290/297.0
LSNKSDFDDDLTKLEVEFRRACKLGVNgtdQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGE-EFSDYINASFITGYQR-KNMYIATQGPLPNTIADF
| .. .  .. |.|. || . ..| ..   ...|.  .||||||. .|||.| . |||  . |  . |||||||...|| . .. .||||||||.|..||
lllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedF

WRMIWEM-----------------CAQYWPLEIDeteEQGDISVTLVEESEeDDDFTVRDIEISHahMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNK
|||.||                  |||||| | .   . ||..|||... . .|..||| .|...   .  |....... |||. |||.|  .|......
wrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflel

SHLHQKEQ-GPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
 . ...|  ...|..|||||| ||||.|||.  .....|.|  .||...|. ||.|||..|| . |..|.| |..|.| 
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

subfamily_PTPRN_pd Subfamily PTPRN 270-525 8e-52 170.8 In-house 19-291 (297) alignment
Range on Protein: 270-525
Range on HMM: 19-291/297.0
SNKSDFDDDLTKLEVEFRRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQ-RKNMYIATQGPLPNTIADFWR
|   |.  . ..|| |.   |.   . . .. |. ..| .|||  ..||.|.. |||..   .| |||||||.|.  . |. .||||||||..|.||||.
syledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwq

MIWE------------------MCAQYWPLEIDETEeqGDISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESG---IDLMRLV
|.||                   |..||| |  |.   .   | || |    ||. || . .   . .. | . |.||  ||| ||| |    ... | |
mvweqGvvvivnltrleeegvkqckrywpdeGsevy..hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkv

NKSHLHqkeqGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEE-SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
|||.         |||||||.|.|||||.|.......|.      ||.  |.  ||.|||..|.  .||.|...|..| 
nksyrG....rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

subfamily_PTPN12_pd Subfamily PTPN12 272-530 1.9e-67 222.2 In-house 7-281 (290) alignment
Range on Protein: 272-530
Range on HMM: 7-281/290.0
KSDFDDDLTKLEVEFRRACKLGVngTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIW
. .|  . .||  . ..  .  |    .. .. ..|. |||   |||.||. |.|..  .|| ||||||.|| | . | .|||.|||||.|. |||||||
eeefakefqklkklsekykaekv..ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

EM------------------CAQYWPLEIDETEEQGDISVTLVEESEEDDDFTVRDIEISHAhmKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLH
|.                  |..||| | .|. | |...||| ||   ||||..| ... .   |. ||..|.|.. ||. |||.|  .|..|... . .
eknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrel

QKeQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESM---IDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQS
|. .  .|.||||||| ||||. ||..   . ...| .   .|||. |. ||.||. .||   |... | |..|..... 
qe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkel

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 274-531 3e-43 142.7 In-house 16-298 (301) alignment
Range on Protein: 274-531
Range on HMM: 16-298/301.0
DFDDDLTKLEVEFRRACKLGVNgtdqtfaniDQNKDKNRIGHILPFDKN--VVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIW
.|... ..|. .  . |..|..         ..||  ||  .| ..|.|  ..| .. .     .|||||.| ||..|. .||.|||. .|..||||.||
kfeeqykelkegedksctvgls.........eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

E------------------MCAQYWPLEIDETEEQGDISVTLVEESEEdDDFTVRDIEIS---------------HAHMKDIRKIRQYHFRGWPEVGV-P
.                   | ||||    |.|| | ..||||.|     ||..|.. .                  . |. ... |..   ||. || .
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvy.PdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr

ESGIDLMRLVNKSHLHQKeQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQST
|    |. . .  |  ||  |  |.|||||.. .|.||...... .     |  .|||| .. .|...| .|. | |. . | .. .||. .||
eprtvLqviddvihrqqk.igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 275-532 1e-28 95.3 In-house 11-283 (307) alignment
Range on Protein: 275-532
Range on HMM: 11-283/307.0
FDDDLTKLEVEFRRACKLGVNGTdqTFANIDQNKDKNRIGHILPFDKNVVKLErlIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE--
.|  ...|  |||  .|   .|   |   .. | ||||   .   ||. . ..  .    |||| | ..    . . .|..|||| ||. .|| |. .  
ldkgvqalvdefrvlakktpegv..tveafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqek

----------------MCAQYWPLEIDETEEQGD----ISVTL--VEESEEDDDF-TVRDIEISHAhmKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNK
                 | ||||||  ..   |.    |||.   ...   |.|.  | ....  |  .. | |... .  ||. |||.  .  . |.. 
vesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa..qksrtiqhlqwenwpdrgvpqinltainllea

SHLHQkeqgpKPIVVHCSAGSGRTGVFIALNVLMSRM-EEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTE
 . ..      |.||||||| ||.|  .|. ... .| . .   |. . |. ||.||.. .|. ||. . .  ..||. |.  |
vrydt.....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyke

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 275-530 7.3e-27 88.8 In-house 19-293 (305) alignment
Range on Protein: 275-530
Range on HMM: 19-293/305.0
FDDDLTKLEVEFRRACKLGVNGTDQTFANIDQN----KDKNRIGHILPFDKNVVKLERLIgeeFSDYINASFITGY-QRKNMYIATQGPLPNTIADFWRM
.|  . ||  |||. .|       |.  | .|     . |||   .   |...|||..      |||| | ..      .. .|..|||| .|| .|| |
ldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwm

IWE------------------MCAQYWPLEIDETEE-QGDISVTLVEES---EEDDDFTVRDIEISHAHMKDIrKIRQYHFRGWPEVGVPESGIDLMRLV
. .                   ||||||.   |  | .. | |  |  |   | | .  .  ......  . .  .|. ..  ||. |||   .  . |.
viqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkm.svrhlqwtewpdrgvppckltslell

nkSHLHqkeQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMI-DVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQS
  | .        ||||||||| ||||  .|.. .. .. |.     . . |. ||.|| . .|.  |. | .  |..|. |. 
..sair...gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky

0047943 (Phosphotyrosine protein) phosphatases II 277-526 1.2e-80 266.2 In-house 9-272 (273) alignment
Range on Protein: 277-526
Range on HMM: 9-272/273.0
DDLTKLEVEFRRACKLGVnGTDQTFANIDQNKDKNRIGHILPFDKNVVKLerliGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE----
..||.|. ||.. ..| .   . ..|.  .||||||. .|||.|.. |||    |.. |||||||...||..|. .||||||||||..|||||.||    
lgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

--------------MCAQYWPLEIDE-TEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQ
               |||||||| .| ... |...|||..| . .||.||| .|... . .. |.....|. |||. |||.|  .|...... . .... 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-GPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
 ...|.||||||| ||||.|||| .|....|.| ..||...|. ||.|||.||| . |..|.| |..|||
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0043336 (Phosphotyrosine protein) phosphatases II 277-526 2.9e-75 248.6 In-house 17-277 (278) alignment
Range on Protein: 277-526
Range on HMM: 17-277/278.0
DDLTKLEVEFRRACKLGVngTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE----
.. |.|. || . ..  .   ....|.  .||||||. .|||.| . |||. | |.. |||||||...||.... .||||||||.|..|||||.||    
nlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvt

--------------MCAQYWPleiDETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKeQG
               ||||||   ..... ||..|||..| . .||.|||..|...   .  |....||. |||. |||||  .|...... . ...   
tivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.ds

PKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
..|..|||||| ||||.|||| .|....| |  .|....|. ||.|||..|| . |..|.| |. |||
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_PTPRA_pd Subfamily PTPRA 277-372 6.6e-30 99.1 In-house 29-123 (330) alignment
Range on Protein: 277-372
Range on HMM: 29-123/330.0
DDLTKLEVEFRRACKLGVNGTDqTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE
||  ..  ||       ...|    |. ..||.|||. .|||.| . | |  . |.| ||||||||| ||..|. .||.|||. .|. ||||||||
ddnklfreefnalPagpiqatl.elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiwe

0036941 (Phosphotyrosine protein) phosphatases II 278-529 8.5e-80 263.5 In-house 11-280 (297) alignment
Range on Protein: 278-529
Range on HMM: 11-280/297.0
DLTKLEVEFRRACKLGVNGTdQTFANIDQNKDKNRIGHILPFDKNVVKLerliGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE-----
.|..|. ||.. ..| ..|.  . |.  .|..|||  .|||.|.. |||    ..| |||||||...||..|. .||||||||||..|||||.||     
flalllkefeellpllllgs.lsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

-------------MCAQYWPLEIDETEEQGDISVTLVEESE-EDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQ-
             .||||||||..|. . ||..|||..... ..||.|.| .|...   .. |.....|. |||. |||||  .|...... . ..|.  
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

GPKPIVVHCSAGSGRTGVFIALNVLMSRME---EESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
...|..|||||| ||.|.|||. ......|   .|  .|....|. ||.|||..|| | |..|.| |. |.|  .
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

0040438 (Phosphotyrosine protein) phosphatases II 278-529 2.3e-79 262.3 In-house 16-279 (317) alignment
Range on Protein: 278-529
Range on HMM: 16-279/317.0
DLTKLEVEFRRACKLGVNgtDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE-----
| |.|. ||.. ..| ..  . ..|.  .||||||. .|||.| . |||  | | . |||||||...|...|. .||||||||||..|||||.||     
dftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

-------------MCAQYWPLeiDETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKeQGP
             .|||||||  .|| . ||..|||..| | ....|.| .|...   .. |.....|. |||. |||.|  .| ..... . ... ...
ivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpg

KPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
.|..|||||| ||||.|||. ......|.|  .||...|. ||.|||..|| ..|..|.| |. |||   
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 278-532 5.4e-67 221.1 In-house 20-289 (305) alignment
Range on Protein: 278-532
Range on HMM: 20-289/305.0
DLTKLEVEFRRACKLgvnGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM----
. ..||....  ...   ..     . ..|| |||  .| ..|.. ..|     .. |||||||.. ||.||. ||..||||.||.|||||.|.|.    
sdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

--------------CAQYWPLEIDETEEQGDISVTLVEEsEEDDDFTVRDIEISH-AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQG
              | |||| .. |..| |..||.| .| ..  |.. |...||   . |. | . ||..  ||. |||..   |..|... . .||.. 
ivmltklveggkdkCrqYWpesktekkefgefsvelkse.ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

PKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTE
 .|..|||||| ||||||||... . |...| ..|||. .. ||..|. ||| |.|. |.. |. |...   |.
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdts

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 278-528 4.7e-39 129.0 In-house 4-261 (267) alignment
Range on Protein: 278-528
Range on HMM: 4-261/267.0
DLTKLEVEFRRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEefsdYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM----
. ...| ||    |.  . .  .     .|...||. . ||.|...| |     |    |||||.. ||..||..|.||.|| |||.||. .| .     
eeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpv

-----------CAQYWPLEIDETEEQGDISVTLVEESEEDdDFTVRDIEISHAHmKDIRKIRQYHFRGWPEVGVPEsgIDLMRLVNKSHLHQKEQGPKPI
             ..|| .. ....  |..|    | ||. |. .  .|.     .  ...  |... |      .    |  |.      | |.| .|.
ivlltkvftdnirlfwPPkmgqakkyqdltvehslekeen.dyqiitlelkfkn.esahnvtlyyykkwnintnnk..pylkplfgilaknqlengnrPl

VVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
||.||.| ||.| |. ..  . |. .|.. |.|. .| .|.||. .|. . .. ...  ..|| | 
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 280-534 7e-73 240.5 In-house 23-291 (319) alignment
Range on Protein: 280-534
Range on HMM: 23-291/319.0
TKLEVEFRRaCKLGVNGtDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM------
|.|| ||.   | .||  . . |. ..||.|||   ||..|.  |.|  | | | ||||||||| |||... .||||.|| ||| |||||.||       
tllekefkl.lkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

------------CAQYWPLEidETEEQGDISVTLvEESEEDDDFTVRDIEIsHAHMKDI--RKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGP
            . .||| |  . || | . ||| || || .|. .|.... . .  ..  |.. ....  ||. .|||..  |. |... .  ....  
mltklveklkvklkkywpee..nfeeyGrlivtl.eeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqs

KPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEYQ
.|||||||||.|||| ||.|.. . |..||...|||.||. || ||. |||  .|.||.| |..|..|  .||..
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteie

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 281-530 4.9e-69 227.6 In-house 22-283 (288) alignment
Range on Protein: 281-530
Range on HMM: 22-283/288.0
KLEVEFRRACKLGVNGTdQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE--------
 .. |..   .|. . . .| ..  .|..|||   |||.| . |||. |  |. .||||||.| |...|. ||||||||..|. |||....|        
gfseeynsLaalektks.vtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivm

---M-------CAQYWPLEiDETEEQGDISVTLVEESEeDDDFTVRDIEIShaHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQgPKPI
   .       | .||| . |. .. |.. |||||. |  .||..| ...   . |. ..| ||.. .||. |||||  .|. |... .  ....  .||
ltelveggktkCeeYWPda.dkpknyGsvtvtlveske.ledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpi

VVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQS
.|||||| ||||.||||. |. ..||| .|||. ||  ||.||. .|| | |. |.|.....  ||..
ivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg

subfamily_CG7180_pd Subfamily CG7180 281-526 3.6e-49 162.0 In-house 14-290 (296) alignment
Range on Protein: 281-526
Range on HMM: 14-290/296.0
KLEVEFRRACKLG--VNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------
| .||..  .||   ..  |   .   .|..|||  ...|.|.| | ||.| |||.||||||... .. .|. || |..|  .|. .|||....      
kfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisav

-----------MCAQYWPLEIdeTEEQGDISVTLVEEsEEDDDFTVRDIEISHA----------HMKDIRKIRQYHFRGWPE-VGVPESG---IDLMRLV
           |. .||| .    |. |.| | .||| ..  ... | . . .              . | ....... |.    || |    |.|.| |
vvLtktfdfakmypsywpnks..keqygeifveivee.kqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

NKSHLHQ-KEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
..   .  ...  .|.||..| |..|.||..|... .  .|.|  .|||. |. ||..||..|.   ..|..|  . |..
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_ptpA1_pd Subfamily ptpA1 281-374 2.4e-20 67.7 In-house 22-113 (418) alignment
Range on Protein: 281-374
Range on HMM: 22-113/418.0
KLEVEFRRaCKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNmYIATQGPLPNTIADFWRMIWEMC
|.. |||   .  |  .. .  .  .|  |||   ||| ..  |.|...  .| |||||| .| |   |. .|.|||||||||||||||.||  
kikeefrl.leesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenr

0046845 (Phosphotyrosine protein) phosphatases II 282-528 1.6e-82 272.4 In-house 2-276 (284) alignment
Range on Protein: 282-528
Range on HMM: 2-276/284.0
LEVEFRRACKLGVNGT-DQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGE-EFSDYINASFITGY-----QRKNMYIATQGPLPNTIADFWRMIWE--
|| ||.. ..| |. . . ..|.  .|..|||  .|||.|.. ||| .| |. | |||||||...||      .|. .||||||||||..|||||.||  
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

----------------MCAQYWPLEiDETEEQGDISVTLVEESEeDDDFTVRDIEISHAH-MKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQK
                .|||||||| .|. . ||..|||..| . .||.||| .|... .  .  |.....|. .||. |||.|  ||...... . ...
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

E-QGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEES---MIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
.  |..||||||||| ||||.|||| .|....|.|.   ..||...|. ||.|||.||| |.|..|.| |..|||  
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

subfamily_PTPRG_pd Subfamily PTPRG 282-532 2.2e-65 216.0 In-house 21-293 (563) alignment
Range on Protein: 282-532
Range on HMM: 21-293/563.0
LEVEFR-RACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFS-DYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE-------
.. ||     .   .  | ....  .|| |||   |...|.  |||. | |.. . |||||..| |||... .|||||||..|. ||||||||       
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv

-----------MCAQYWPLeiDETEEQGDISVTLVEEsEEDDDFTVRDIEISHAHMKDIR------KIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQK
            | .|||   ||.|. | ..|||.|| |     ||| . | . ..|. .      ..||||.  ||..||||. .  .  |.||   .|
mitnlvergrrkcdvYWPk..desetygalqvtliee.evlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaank

E-QGpkPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTE
.  |  ||||||||| ||||..|.|. |. ....|....||.... .| ||...||.  |. | . |..| .  . ||
aeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 282-529 2.6e-56 185.8 In-house 17-279 (281) alignment
Range on Protein: 282-529
Range on HMM: 17-279/281.0
LEVEFRRACKLGVNGTDQTfANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM--------
.  |..   ..||. | .  .. |.|. |||   |  .|.  ||...   .. .|||||.|. ||. .. |||||||.|.....||.|.||         
fieeyeklaaigvdntata.skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmv

----------CAQYWPlEIDETEEQGDISVTLVEEsEEDDDFTVRDIEIsHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIV
          | .||| . ... . ||. |. ..| ||   .  | ... ...  . |...| ..  ||. |||..  .|.   .. .  ....   |.|
treieagklkChrYWP.ddnselkygdvtvkstae.eekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplv

VHCSAGSGRTGVFIALNVLMSRMEEE-SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
.||||| ||||..|||. |....|.| ...|| ..|. ||..|  ||| ..|..| | |....|...
ihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 282-533 6e-49 161.4 In-house 12-284 (287) alignment
Range on Protein: 282-533
Range on HMM: 12-284/287.0
LEVEFRRACKLGvNGTDQTFANID--QNKDKNRIGHILPFDKNVVKLERlIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE-------
.. |. . ..   ...  || . .   .  ||| ...||.|.. | |    ||  |||||| ....|.... .||.|||.. |. ||||...|       
vdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

-M----------CAQYWPLEiDETEEQGDISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKS--HL--HQKEQ
 |          | .|||   .     |  ||.|.. .  . ...|| . . ... .. | ..|...  ||. ... . . |.|.| .   |.   .. .
tmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardas

GPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEY
.  |.|||...| ||.|...|. ||.||.|.   .|| ..|  ||..|  .||   |... | |.| | . .   |
evGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnpqly

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 282-524 9.5e-49 160.8 In-house 8-264 (283) alignment
Range on Protein: 282-524
Range on HMM: 8-264/283.0
LEVEFRRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGeefsDYINASFIT---GYQRKNMYIATQGPLPNTIADFWRMIWE------
 .. . .  .|.|   | . |  |.|| |||  .|.| |...|.|. .      |||||.||.    |.... ||..|.|| .|. |||.|...      
nklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

------------MCAQYWPLEidETEEQGDISVTLVEESEEdDDFTVRDIEISHA-HMKDIRKIRQYHFRGWPEVGvPESGIDLMRLVNKSHLHQKEQGP
             |.|||| .   .|. |.  ||| .|  . . |... . . .    |.   .  | . .| |.| ... |. .  .||    |.|.  
vmltklqedlrikCsqyWPkr..GsedyGeftvtlrketts.nsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskk

KPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
 |||||||.| |||.||||. . .  .  ||..|||..|. .|.||. .|| | |.|. . ...|
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 283-526 5.1e-140 460.9 In-house 1-256 (284) alignment
Range on Protein: 283-526
Range on HMM: 1-256/284.0
EVEFRRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE----------
|||||||||||||||||||||.|||||||||||||.|||||||||||||||||||||||||||||||..||||||||.||.|||||||||          
evefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt

--MCAQYWPLEIDETEEQGDISVTLVEESEEdddFTVRDIEISH-AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNK-SHLHQKEQGPKPIVVHCSA
  .|.|||||.|...||.....|..||||||   ..|||||.|. ...||||||||.||.|||.||||....||||||.| .||..||.....|||||||
kdkcsqywplkivikeerfkvkvdsveesee...yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

GSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE-YL
|.|||||.|.|.||..||.||...||...||.|||||...||||.|.||.|||..| .|
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_PTPN14_pd Subfamily PTPN14 283-376 1.1e-18 62.3 In-house 26-119 (300) alignment
Range on Protein: 283-376
Range on HMM: 26-119/300.0
EVEFRRACKLGVNGTDQTfANIDQNKDKNRIGHILPFDKNVVKLERLIgEEFSDYINASFITG--YQRKNMYIATQGPLPNTIADFWRMIWEMCAQ
 .|. |  |   ... .| |. ..|..|||. ..||...| |.|     |. ..||||| |      ..  ||..||||..|. |||.|.||   |
fteyeripkkredallst.aklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

DSPc_SM00195 284-526 3.5e-74 244.8 In-house 4-262 (263) alignment
Range on Protein: 284-526
Range on HMM: 4-262/263.0
VEFRRACKLGVNGtDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM----------
 ||..  .   .  . | |....||.|||  .|||.|.. |||..  ..| ||||||..|.|...|. |||||||||.|..|||||.||.          
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

--------CAQYWPLEIDETEEQGDISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQgPKPIVVH
        |..||| |....|. |.|||.|||. ...|....|..|...   .. ||..||....||. |||.|  ....|... . .....  .|||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVh

CSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|||| ||||.|.......|..|||...|.|..|. ||.|||.||| |.|..|.| |..||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 284-526 3.5e-74 244.8 In-house 4-262 (263) alignment
Range on Protein: 284-526
Range on HMM: 4-262/263.0
VEFRRACKLGVNGtDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM----------
 ||..  .   .  . | |....||.|||  .|||.|.. |||..  ..| ||||||..|.|...|. |||||||||.|..|||||.||.          
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

--------CAQYWPLEIDETEEQGDISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQgPKPIVVH
        |..||| |....|. |.|||.|||. ...|....|..|...   .. ||..||....||. |||.|  ....|... . .....  .|||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVh

CSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|||| ||||.|.......|..|||...|.|..|. ||.|||.||| |.|..|.| |..||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Ptp69D_pd Subfamily Ptp69D 285-372 1.3e-27 91.8 In-house 27-113 (307) alignment
Range on Protein: 285-372
Range on HMM: 27-113/307.0
EFRRACKLgVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE
|...  .      . .... . |. |||  .| .|||. |||....|.| ||||||||| ||. |. .|| |.|. .|| ||||||.|
eyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiae

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 287-534 5.6e-56 184.8 In-house 31-292 (297) alignment
Range on Protein: 287-534
Range on HMM: 31-292/297.0
RRACKLGVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRknMYIATQGPLPNTIADFWRMIWE--------------
.. | .  | . || |.   | .|.|   |||.|.. |||. .  .  |||.||||. |..    .|.|| | ..|.||||.|...              
eflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddne

---MCAQYWPLEIDETeeQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPE-----SGIDLMRLVNKSHLHQKEQgpkPIVV
    ||.||. .   |   ||.||.|    .|   |  |..|... . |  | ..||.|  ||.  |..     | ..|.  |.|.. ...|    |..|
rdkkcaryWsdkgvtt..fGdvsvvlls.vsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg...Pllv

HCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEYQ
||.|| |||||.....  ......|  .|.|..|. |||.||..||   |.|| | |..|.|  . |. |
hclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriq

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 291-528 2.4e-56 185.9 In-house 13-270 (274) alignment
Range on Protein: 291-528
Range on HMM: 13-270/274.0
KLGVNGtDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEE-FSDYINASFITGYQRK-NMYIATQGPLPNTIADFWRMIWE----------------
.| .|  ||   ..  .. |||   ||| ..  | ||.  .|.  |.|||| .| ||... ..|.|||||||||.|||||||..                
elPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkean

--MCAQYWPLEIDE--TEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMkdIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPK--PIVVHC
   ||.|.| ..|   .|. ||.... ..   | .|..|| . .....    |..  | .  ||.  .|..   |..||.. .  ..|.  |  |.||||
eqkCavyfPdaedyeiserygdveikvek.iverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhC

SAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
||| ||||.||| .. . ...||...||...|  ||..|  |||   |... . |...||..
saGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 293-528 1.6e-56 186.5 In-house 29-278 (515) alignment
Range on Protein: 293-528
Range on HMM: 29-278/515.0
GVNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MC
| |   || |. . |  ||| . |||.|.. |||| .  .  |||.|||.| ...  . |||.|||.. .. ||||....                   |
gpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikc

AQYWPLEIDETEEQGDISVTLVEeSEEDDDFTVRDIEISHAhmKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkEQGPKPIVVHCSAGSGRTG
..|||    .. . | |.| ||   | . . . | ... .   .|.| . |.|| .||. |||.    |..|. .    . .|   |...||||| ||||
gkyWPdkpgdsvkfGsikvelvs.leactggikrkltvlkg..ddsrtvtqfhfteWPdkGvpkhtssllklikevkadh.gqythpliihcsaGvGrtG

VFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
|.|...  ......  |.|||..|. .||.||..||   |. | | |. |.|  
vvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllw

subfamily_PTPN9_pd Subfamily PTPN9 294-528 8.7e-66 216.9 In-house 30-292 (297) alignment
Range on Protein: 294-528
Range on HMM: 30-292/297.0
VNGTDQTfANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM------------------CA
|.|| .. ...  |  |||   .| .|.  |.|... ..| ||||||.|. ||..|. .|||||||..|. |||||.||                   |.
veGtfla.sklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcg

QYWPLEIDETEEQGDISVTLVEEsEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQ---------KEQGP---KPIV
|||||| ....| ||.||. ||  || .|..|| .||.... ...||.  . | .||. |||.|. .|. ...|   .|         ...|.    |||
qyWpleeessaefgdlsvsnvev.eeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPiv

VHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
|||||| |||| ||.|.. .||.||....||..||. ||.|| ...|   |..||| |..||  |
vhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 294-529 3.5e-59 195.6 In-house 35-291 (325) alignment
Range on Protein: 294-529
Range on HMM: 35-291/325.0
VNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMI--WE---------------MCAQ
..|  .. |   .||.|||   ....||. | || .  .  |||||||..  ...|....|.| ||..|| |.||..  |.                ||.
ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcav

YWPLEIDETEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPE---SGIDLMRLVNKSHLH--QKEQGPKPIVVHCSAGSG
||| |. .. . | . | |.   ||  |.  | ...  ..  . | ..|.....|...||..   . | ...||.. .     . ..  ||.|||||| |
ywpkemgksktfGglevklrt.ieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvG

RTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
||||||.|  .. .. ||| .|.|. |. ||..|| ||.   |. ..| |.||..   
rtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 294-357 2.4e-11 37.7 In-house 35-95 (95) alignment
Range on Protein: 294-357
Range on HMM: 35-95/95.0
VNGTDQTFANIDQNKDKNRIGHILPFDKNVVKLerlIGEEFSDYINASFITGYQRKNMYIATQG
  |.  |    . |  |||.  |.|.|   | |        |||||| |. || ||| |||.||
tsgapytvgsseanipknrflnifpydatrvvl...ttkrdsdyinacfvdgyarkncyiaaqg

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 296-530 3.9e-55 181.8 In-house 35-287 (290) alignment
Range on Protein: 296-530
Range on HMM: 35-287/290.0
GTDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEF--SDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCA
    | ..  .|| .||  .|.. | | . | .. |..    .||||..| ||. |. |||||||..||..|||..||.                   | 
ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCq

QYWPLEidETEEQGDISVTLVEESEEDdDFTVRDIEISHAHM-KDIRKIRQYHFRGWPEVG-VPESGIDLMRLvNKSHLHQKEQGPKPIVVHCSAGSGRT
|||| .  .|.. | .|..|..|.. . ... | .|. . .  .. ... ||..  |.. | |..    |. . ..    |. .| ..||||||.. ||.
qYWpds..dtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi.eemyktqrkrgntsivvHCSdtvgrs

GVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQS
.||.|... . ... |  ||||| .. .|.|.| .||   |... .. ...||.. .
avfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe

subfamily_PTPN3_pd Subfamily PTPN3 296-528 2.3e-50 166.1 In-house 30-277 (280) alignment
Range on Protein: 296-528
Range on HMM: 30-277/280.0
GTDQTFANIDQNKDKNRIGHILPFDKNVVKLERligEEFsDYINASFI----TGYQRKNMYIATQGPLPNTIADFWRMIWE------------------M
| . . |.  .| .|||   |||.|.  |||.    .|  |||||...     . .  | ||||||||..| .|||.|.||                   
glaisaarkpenlsknryrdilpydatrvklke...set.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CAQYWPLeIDETEEQGDISVTLVEEsEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHlHQKEQGPKPIVVHCSAGSGRT
| ||||   ... | |..||.. .| .|.  . .|.. ..... |. ||| |  .  ||. |||..  |....|.. . ....   .|.||||||| |||
ChqyWPe.tedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervr.klrsgkeePvvvhCsaGigrt

GVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
||.|.|.. .. .|..  . . . || .|.||  .||  .|.||   |...  ||
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee

0045098 (Phosphotyrosine protein) phosphatases II 297-527 9e-67 220.7 In-house 23-273 (278) alignment
Range on Protein: 297-527
Range on HMM: 23-273/278.0
TDQTFANIDQNKDKNRIGHILPFDKNVVKlerligeefsDYINASFITGYqrKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYW
 . |.|.   |.||||. .|||.| . ||          ||||||.|.||  .. .||||||||.|.||||||.||                   |||||
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PlEiDETEEQGDISVTLVEESEEdDDFTVRDIEISHA----HMKDIRKIRQYHFRGWPEVGVPESG--IDLMRLVNKSHLHQK------------EQGPK
| | ..... ||..|||..|..  ||.|.|.... .     .    |.....|. .||. |||..     . .|..  . ..|            .....
p.e.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PIVVHCSAGSGRTGVFIALNVLMSRMeeESMIDVFQTVRGLRQQRPH-MVQDLAQFKFCYSAMVEYLE
|..|||||| ||||...|.  .....  |. .|....|. ||.|||. .|| | |..|.| ...|.|.
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_PTPN6_pd Subfamily PTPN6 297-531 3.6e-61 201.8 In-house 44-302 (306) alignment
Range on Protein: 297-531
Range on HMM: 44-302/306.0
TDQTFANIDQNKDKNRIGHILPFDKNVVKLErLIGEEFSDYINASFITGYQR--KNMYIATQGPLPNTIADFWRMIW------------------EMCAQ
 ... ..  .|| |||.  |||||...|.|.   .   ||||||..|.. ..  .. |||||| |..|..|||||.|                  |.||.
lsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCar

YWPLEIDETEeQGDISVTLVEEsEEDDDFTVRDIEISH-AHMKDIRKIRQYHFRGWPEVGVPESGI---DLMRLVNKSHLHQKEQGPKPIVVHCSAGSGR
||| | ...|  |.|||| |.| .. .|...|.. .|.  . |. |...||||. ||. |||..     |... ||. . . .|. . ||||||||| ||
YWPdeeekee.yGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGR

TGVFIALNVLMSRMEEE---SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQST
|| || ...|.. .|..     ||. ..|. .|.||  .||  .|.|| | |. .|.|....
tGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 297-526 4.8e-47 155.2 In-house 35-236 (392) alignment
Range on Protein: 297-526
Range on HMM: 35-236/392.0
TDQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEMCAQYWPLEIDEteEQGDisvtlv
 .|| |. . |. ||| . |||.|.. |||| .     |||.|||.| ... .. |||.||| . .. |||||...  .    .  .   ..||      
ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtkl..kegd......

eeseedddftvrdieishaHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLhQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQ
                   . .| | . |.||  ||. .||.    |...... .  .  |  .|...||||| ||||| |... .... ..  |.|||.
...................kgddartvaqfhftewPdkdvpkhtssllkfikevka.dfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfn

TVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
 |  .|..||.|||   |. | | |..| |
fvtnirrkrpymvqtkeqyafiygavledl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 298-529 8.3e-57 187.4 In-house 35-280 (315) alignment
Range on Protein: 298-529
Range on HMM: 35-280/315.0
DQTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWP
 |. |  ..|  ||| . |||.|.. |||| .  .  |||||||.| ...  . |||.||||. .. |||||...                   |.||||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

LEIDETEEQGDISVTLVEEsEEDDDFTVRDIeiSHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHqKEQGPKPIVVHCSAGSGRTGVFIAL
 .  .. | | |.|.|..  | | | ..| .     . .. |.. |..|..||. ||..    |..|. .     ...   ...|||||| |||||.|..
drkadsvefGsikvellsl.eadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisi

NVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
.  ..........|||..|. ||..||..||   .. | | |. |.|  .
devvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 298-526 8.7e-24 79.0 In-house 26-270 (285) alignment
Range on Protein: 298-526
Range on HMM: 26-270/285.0
DQTFANIDQNKDKNRIGHILPFDKNVVKLErligEEFSDYINASFITGY-QRKNMYIATQGPLPNTIADFWRMIW------------------EMCAQYW
. |..  . | | ||   .   ..  | |.    .   ||| ||..    . .. ||.||||||.|..|||.||.                  | || |.
nctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PLEIDETEEQGDISVTLVEESEEDDDFTVRDI-EISHAHMKD--IRKIRQYHFRGWPEVGVPESGIDLMRLVNksHLHQKEQGPKPIVVHCSAGSGRTGV
| .. |  . |   .|| |  ||    |. .   .  .         . . .   ||.   ||    .. | .   ... .   |||.|||||| |||  
peklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielyk..wvkkvnpkekpicvhcsagvgrtat

FIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|. ..    |. |.  |.... || .|  | . ||   || | |  ..||.
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 298-525 4.9e-23 76.2 In-house 43-289 (310) alignment
Range on Protein: 298-525
Range on HMM: 43-289/310.0
DQTFANIDQNKDKNRIGHILPFDKNVVKLErLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWP
  |.    ..  |||   ..  |.  |||. .    . ||| | ..     .. .| .||||  || ||||||..                   |  |||
sltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp

lEIDETEEQGDISVTLVEESEEDDDFT------VR-D--IEISHAHMKDIRkIRQYHFRGWPEVGVPESGIdlmRLVNKSHLHQKEQGPkpIVVHCSAGS
  .  ||  | | || . || |. .        |  .  ..   | .|..| .   ..  ||. |||.        | .  | |  .||   ||||||| 
.slgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelr.vslikwpnwpdrgvpdekc...htvpqrllaqvrhgp..cvvhcsagk

GRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
.|..| .||.. . ....   .|. . .  |...|   .|   |. .    .. .
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif

0040439 (Phosphotyrosine protein) phosphatases II 299-526 1.7e-71 236.0 In-house 3-246 (249) alignment
Range on Protein: 299-526
Range on HMM: 3-246/249.0
QTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPL
 ..|.   ||||||. .|||.| . |||. | | . |||||||.|.||..|. .||||||||.|..|||||.||                   |||||||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

eiDETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQ-GPKPIVVHCSAGSGRTGVFIAL
  ... | ||..|||... .  ||.||| .|...   .. |....... .||. |||.|  ||...... . ...|   ..|..|||||| ||||.|||.
..ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

NVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
  .....|.|  .|....|. ||.|||..|| . |..|.| |. |.|
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_PTPN1_pd Subfamily PTPN1 299-524 1.8e-42 140.0 In-house 24-269 (290) alignment
Range on Protein: 299-524
Range on HMM: 24-269/290.0
QTFANIDQNKDKNRIGHILPFDKNVVKLERliGEEfsDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPL
.. |. ..|...||   . |.|.  .||||  ..   ||||||..   . |  || ||||||||.. ||.|.||                   |||||| 
treaklpenrnlnryrdvspydhsrikler..adn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

EIDETE---EQGDISVTLVEEsEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRL---VNKSHLHQKEQGPkpIVVHCSAGSGRTG
. .| |   |.  ..|.|..| |. . .||| .|.   . .. |.| ..|.  ||. |||||   ....   | .|   ....||   |.||||| ||.|
geeekellledtklkvklise.erksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGp..avihcsaGiGrsG

VFIALNVLMSRMEE---ESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
 |. .. .. ..|.    | .|. ...  ||..|  ..|   |..| | |..|
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 299-527 1.2e-20 68.8 In-house 35-272 (288) alignment
Range on Protein: 299-527
Range on HMM: 35-272/288.0
QTFANIDQNKDKNRIGHILPFDKNVVKLErligEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPL
..  .  .|  ..|  ..   |   |||.    ..   ||.|  ..  . |.  | .| ||  ||  .|.|. |                    |.|.|.
diidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs

EIDETEEQGDIsVTLVEESEEDDDFTVRDIEISHAHMKDIRK-IRQYHFRGWPEVGVPESGIDLMRLVNKShlhqkEQGPKPIVVHCSAGSGRTGVFIAL
.. |.   | .  | | .. .| | .|.   .   .  . .. ... |.. |.. ||||. .  .||..       ..  ||||||.|||.|||| .|  
klGekarigrl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlili

NVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
 . .  .  .  . . . .  ||..| . .|   |. . .  . |.| 
lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell

subfamily_egg_pd Subfamily egg 299-524 1.8e-15 51.4 In-house 32-268 (307) alignment
Range on Protein: 299-524
Range on HMM: 32-268/307.0
QTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIW----------------EMCAQYWPLEI
 | |  | |..| |  ..   |   ||||   |    |.| |  . |    | .| .| || ||  |||||..                | |  |||   
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkae

DETEEQ--GDISVTLVE-ESEEDDDFTVRDIEISHAHmKDIRKIRQYHfRGWPEVGVPESGIDLMRLVnkshlhqkEQGPKPIVVHCSAGSGRTGVFIAL
...     | . .. .. .|. |  |.|  . .  .. .. | .  .    . ...   | . ..|..         .  ||.||..  |  ......|.
sdslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwq.gdvnnssdvysplrvlrkl........rnlskpvvvqdilGvskaatlvai

NVLMSRMEEE--SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
.. .  .         | ..|  ||..|.  |.   .. | |  .. 
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 299-372 5.8e-10 33.2 In-house 26-98 (332) alignment
Range on Protein: 299-372
Range on HMM: 26-98/332.0
QTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEfsDYINASFITGYQRKNMYIATQGPLPN-TIADFWRMIWE
.|. .. .| | ||| |.  ||.. |.|    |..  |. |||.. || .|. || .| |. . |   ||||. |
ntydkflnnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvse

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 299-345 2.6e-06 21.0 In-house 39-85 (440) alignment
Range on Protein: 299-345
Range on HMM: 39-85/440.0
QTFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITG
   |.. .|| |||   || .|.. | || . |   |||||||.|.|
sdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

subfamily_PTPRD_pd Subfamily PTPRD 300-534 2.6e-87 288.8 In-house 41-289 (564) alignment
Range on Protein: 300-534
Range on HMM: 41-289/564.0
TFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLE
. || ..|| |||  .|...|.. |.|... |.| ||||||||| ||.... ||||||||..||.|||||.||                   |..||| .
eaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek

iDeTEEQGDISVTLVEEsEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkEQGPKPIVVHCSAGSGRTGVFIALNV
 . ||. |.. |||.|| ||  |...|........ .. |..||.||  ||. |||||. .|..|..|.. .. |.. .||||||||| ||||.||....
.g.tetygeltVtleee.eeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivida

LMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEYQ
.. |..|| ..|..|.|. ||.||..|||   |. |...|..|.|. ..|| .
mlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteve

0037934 (Phosphotyrosine protein) phosphatases II 300-526 8.2e-60 197.7 In-house 3-242 (243) alignment
Range on Protein: 300-526
Range on HMM: 3-242/243.0
TFANIDQNKDKNRIGHILPFDKNVVKLerligEEfSDYINASFITGYQRknmYIATQGPLPNTIAD----FWRMIWE------------------MCAQY
..|.. .|..|||  .|||.| . |||     |  ||||||..|... |   .||||||||.|..|    ||||.||                   ||||
siallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPleiDETeEQGDISVTLVEESEEDDdFTVRDIEISHAH-MKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKE-------QGPKPIVVHCSAG
||   .|. . ||..|||..|.. || .||| .....    .  | ...||. .||. |||.|  ||...... . ...|        . .|..||||||
wp...gev.tygdftvtllseehldd.ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

SGRTGVFIALNVLMSRMeeeSmIDVFQTVRGLRQQRPH-MVQDLAQFKFCYSAMVEYL
 ||||..||. ......   . .|....|. ||.|||. .|| . |..|.| |. |.|
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 300-526 7.8e-43 141.5 In-house 41-279 (439) alignment
Range on Protein: 300-526
Range on HMM: 41-279/439.0
TFANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM-------CA------QYWPLEidETE
..|  . .. |||   . .||   | |. . |   | |||| .| ||  ...|||||||  .|  ||||...|         .      .||| .  .  
slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesykywpsd..aev

EQGDISVTlVEESEEDDDFTVRDIEISH--AHMKDIRKIRQYHFRGWPEVGVPESG---IDLMRLVNKSHlHQKEQGpkPIVVHCSAGSGRTGVFIALNV
  |||.|  |.   |  ....| . .     . .  | . |.|.  ||.  ||      .|..| .| .   ..| |  |.||||||| ||||  |||..
cygdiavr.vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan.dkeeyg..pvvvhcsagvGrtGtiialdi

LMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
 . ..  |  .|.   |. ||.|| .|||.|.|. | | |..| .
aleqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

0049772 (Phosphotyrosine protein) phosphatases II 300-532 1.3e-38 128.9 In-house 39-286 (314) alignment
Range on Protein: 300-532
Range on HMM: 39-286/314.0
TFANIDQNKDKNRIGHILPFDkNVVKLERLIGEEfSDYINASFITGYqrkNMYIATQGPLPNTIADF----------WRMI--WEMC-------------
..|..  |.||||  .|||.| | |.| .| ..  |||||||.. |.   . .|||||||..|. ||          |||.  ...              
lvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

----------------------AQYWPLEIDETEeqgdisvtlvEESEEDDDFtvrdieishahmkdIRKIRQYHFRGWPEVGVPeSGIDLMRLVNKSHL
                      ..... .... .          ||  ....|               | . .|.   .|  ..| .  |. ....  . 
delsrLdaAlgKtpllildgngneptaadlellk..........eelydpelf..............erlgikylripvpDgsap.lledfdeflefiee

HqkeQGPKPIVVHCSAGSGRTGVFIALNVLMSRMeeeSMiDVFQTVRGLRQQRP-----HMVQDLAQFKFCYSAMVEYLEEQSTE
.   . ..|..|||.|| ||||.|...  ||...    . .. .... .|..||     .... | |. |.. |. |||. . ..
a...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf

0042113 (Phosphotyrosine protein) phosphatases II 301-527 5e-69 227.7 In-house 3-244 (245) alignment
Range on Protein: 301-527
Range on HMM: 3-244/245.0
FANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLei
.|.   ||||||. .|||.| . |||    |...|||||||...||.... .||||||||.|..|||||.||                   |||||||  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

DETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVL
.|. . ||..|||..|   .||.||| .|...   .  |....||. .||. |||..  .| ....  . ...| ...|..|||||| ||||.|||.  .
gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

MSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
....|.|  ......|. ||.|||..|| . |..|.| |. |.|.
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 301-531 9.6e-54 177.3 In-house 41-283 (287) alignment
Range on Protein: 301-531
Range on HMM: 41-283/287.0
FANIDQNKDKNRIGHILPFDKNVVKLErligEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLEi
 .   |||||||. .||. |.. | |.    .|  |||||.|| ||. |. .|....|. ||. .||..|..                  .| |||| | 
hniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpee.

dETEEQGDISVTLVEESeEDDDFTVRDIEISHAH-MKDIRKIRQYHFRGWPEVG-VPESGIDLMRLvNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALN
 ..   |. ...|..|    .....|..|. . .  .| ....||..  |.. | |.|    |. . ..    |. .|  .||||||.. ||...|.| .
.ksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi.eemyktqrkrgntsivvhCsdtvGrsamfcaaa

VLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQST
. . . ..|  ||||| ..  |.|.|..||  .|.|| . ...|||.  .|
ttinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet

subfamily_PTPN13_pd Subfamily PTPN13 301-373 6.9e-19 63.2 In-house 31-100 (273) alignment
Range on Protein: 301-373
Range on HMM: 31-100/273.0
FANIDQNKDKNRIGHILPFDKNVVKLERLIGeefsdYINASFITGYQRKN--MYIATQGPLPNTIADFWRMIWEM
 .. ..||||||  ..||.|.  |||.   |     |||||.|     |.   |||.|||||.|..|||.|.|| 
vgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweq

subfamily_PTPRK_pd Subfamily PTPRK 302-524 1.6e-63 209.5 In-house 38-275 (314) alignment
Range on Protein: 302-524
Range on HMM: 38-275/314.0
ANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM------------------CAQYWPleiD
|. |.|..|||.|.||..|.  |.|  . |.  ||||||..| .|.| . .|.|||||..|..||||....                   | .|||   .
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP...e

ETEEQGDISVTLVEeSEEDDDFTVRDIEISH--AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEqGPKPIVVHCSAGSGRTGVFIALNV
.||  ||| |.||| .| . .. ||   ...    ...||..||..| |||. .|| |   |..|| . . .|.| .  .||||||||.||||.|||...
dtevygdikvelve.tellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidi

LMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
..  .|.|...|||..|. ||.... ||.   |.||.| ...|
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 302-528 3.8e-63 208.0 In-house 4-244 (250) alignment
Range on Protein: 302-528
Range on HMM: 4-244/250.0
ANIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE-----------------MCAQYWPleIDE
|.  |||.|||  .|...|.  | ||.  |.. ||||||||. ||. ....|||||||..|| |||||..|                  . ||||  ...
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywP..vek

TEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMS
.|. ||. |.| . .||  |.|.| . .|.|. .| | .||.||  ||. ||||     . |..| .  |.. | .|..|.|||| ||.| |||.. .. 
aekyGdvtvslls.keefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

RMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
|...| ..|||. .. ||..|||.|. |.|. |.|... ..|. 
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 302-524 6.5e-21 69.2 In-house 32-267 (281) alignment
Range on Protein: 302-524
Range on HMM: 32-267/281.0
ANIDQNKDKNRIGHILPFDKNVVKLER-LIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIW------------------EMCAQYWPLEI
 |   |. |||   |  .|   |.|.  .  .. .||| | .|     |  || ||||  .| ||||||||                  | ||.|.| . 
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

DETEEQGDISVTLvEESEEDDDFTVRDIEISHahMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkeqgpKPIVVHCSAGSGRTGVFIALNVL
    .   .||.  |.|  .  .    ...|.    . | | .. .. ||.  ||||   ..... | . .       | |.||||| ||.| ..|... 
hcclqfdklsvsy.edstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrkirars.....tppvihcsagvgrsgtlmaveia

MSRME-EESMIDVFQTVRGLRQ-QRPHMVQDLAQFKFCYSAMVE
.  .    .. |. | |  ||   |   || | |. . .  ...
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 303-529 1.1e-48 160.6 In-house 16-267 (270) alignment
Range on Protein: 303-529
Range on HMM: 16-267/270.0
NIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQ-RKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLEID
.. ..|  ||   |||  .  |.||.|  .. . |||| .. |.. .|. |||..||||.|. .|||||||                   |..||| | .
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

E--TEEQGDISVTLVeESEEDDDFTVRDIEIShaHMKDIRKIRQYHFRGWPEVGVPESGI------DLMRLVNKSHLHQKEQGP-KPIVVHCSAGSGRTG
|  . |.|.|.|. . ..| .. . .. ...   .  ..|..  ...  ||. |||..        .|...... . ..||.   .|..|||||| ||||
ekvkledgkikvlal.seekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

VFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
..|||.  .  .||.. .|| . .. ||..|. .||   |..| | |.||| | .
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 303-372 6.4e-29 96.0 In-house 42-111 (318) alignment
Range on Protein: 303-372
Range on HMM: 42-111/318.0
NIDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE
. . || |||   ||..|.  |||. | ||| ||||||..| ||.||. |||.|.|||.|| |||||.||
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWe

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 304-525 3.3e-59 195.4 In-house 46-278 (315) alignment
Range on Protein: 304-525
Range on HMM: 46-278/315.0
IDQNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPleiDET
  .||.|||  .|...||  |.|  |  .. |||.||.|| ||..|..|||.|||..... ||||...|                  .. .|||   |. 
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp...dkk

EEQGDISVTLVEEsEEDDDFTVRDIeiSHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGpKPIVVHCSAGSGRTGVFIALNVLMSR
   | |.||...| |  ...||| .  |    ..||.. |.|.  ||..|||.. | || |. . . |....   .|||||||| |||| ||.|. .. .
viyGkitvtrkse.evnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldq

MEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
.| | .|||.. ..|.||.| .||| ..|..| |.|..| 
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 304-370 2.9e-08 27.7 In-house 51-114 (290) alignment
Range on Protein: 304-370
Range on HMM: 51-114/290.0
IDQNK--DKNRIGHILPFDKNVVKLERliGEEfSDYINASFITGYqrKNMYIATQGPLPNTIADFWRMI
.|.|    |||   .   ||  | |.   | .  ||. | .. |   | |.| |||.| .|. |.|||.
fdkntefkknrykdvvcndktrvilkd..Gyd.GdyvhanyvkGl..kamfiltqGalkdtvidiwrmv

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 305-529 1.3e-15 51.9 In-house 41-279 (312) alignment
Range on Protein: 305-529
Range on HMM: 41-279/312.0
DQNKDKNRIGHILPFDKNVVKLerlIGEEfSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEMCAQYWPLEIDETEEQGDIS----VTLVEE--
 . || ||   |  .|.    |    |.|   || | |.    . . ...||||| ||.. ||..   . .    | .   |.  . .      .|    
lkfkdlnrypniqcwdrgrftl...agde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

SE-----------------EDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKShlhQKEQgpKPIVVHCSAGSGRTGVFIALNV
 |                   |  | | . .      .  |. .| .  ||. |.|.|    .||.      .|..  ||.. ||||| |||| .. .. 
ledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav...kkdk..kpviahcsagvgrtgtlalies

LMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
... .      .| ..   ||..|   |. ..|. ..  ...|.|  .
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 305-373 2.2e-12 41.1 In-house 94-160 (244) alignment
Range on Protein: 305-373
Range on HMM: 94-160/244.0
DQNKDKNRIGHILPFDKNVVKLERliGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM
 .|  ||| |  |||| | | | .  |     ||||||.    |   || || || .|  |||.|. | 
pnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmler

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 305-371 1.2e-09 32.4 In-house 46-109 (305) alignment
Range on Protein: 305-371
Range on HMM: 46-109/305.0
DQNKDKNRIGHILPFDKNVVKLErliGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIW
 |...|||   .  .|.| ||||   |    .|| | ...     . .| || || .| |||| | .
aqeagknrykdvgcldnnrvkle...gpwpheyihanyvstptnpkrfictqaplektcadfwymcl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 305-372 9.7e-08 26.0 In-house 45-105 (303) alignment
Range on Protein: 305-372
Range on HMM: 45-105/303.0
DQNKDKNRIGHILPFDKNVVKLERligeefSDYINASFITGYQRKNmYIATQGPLPNTIADFWRMIWE
 .| ||||.  .. .|.  |||        | || ||..    .|.  | || ||. | ||||.|| |
vknmdknrfvdvicldhskvklsd......ssyihasyleldsskk.ailtqlplshtaadfwqmiie

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 306-524 1.7e-39 130.4 In-house 6-238 (239) alignment
Range on Protein: 306-524
Range on HMM: 6-238/239.0
QNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQR-KNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPleiDETE
 || |||   |. .|.. | ||.|  . .|||||||..  |.   . |||||| .  .  |||||.|.                   | ||||   | | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dsts

EQGDISVTLVeESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHlHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRM
.  .. |||  ..|   |. .| . .|.    . | . ||||  ||. |||.    .. |  |   ..   | .| |.||||| |||| |. .. .. . 
kycnlrvtlr.ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqa

EEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
...  .|.|. |. .|..||||||   |. | . |..|
kkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 306-524 2e-39 130.1 In-house 7-239 (239) alignment
Range on Protein: 306-524
Range on HMM: 7-239/239.0
QNKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQR-KNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPleiDETE
 || |||   |. .|.. | ||.|  . .|||||||..  |.   . |||||| .  .  |||||.|.                   | ||||   | | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dsts

EQGDISVTLVeESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHlHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRM
.  .. |||  ..|   |. .| . .|.    . | . ||||  ||. |||.    .. |  |   ..   | .| |.||||| |||| |. .. .. . 
kycnlrvtlr.ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqa

EEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
...  .|.|. |. .|..||||||   |. | . |..|
kkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 306-523 4.4e-39 129.1 In-house 2-236 (237) alignment
Range on Protein: 306-523
Range on HMM: 2-236/237.0
QNKDKNRIGHILPFDKNVVKLERLIGEefSDYINASFITGYQR-KNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPlEIDETE
.|| ||| | |  .|.. | |.   ..  ||||||... |..   . |||.|||| ..  |||.|.|.                   | .||| . |. .
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpa

EQGDISVTLVEeSEEDDDFTVRDIEISH-AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKShLHQKEQ--GPKPIVVHCSAGSGRTGVFIALNVLM
  | ..|.|    ||  |.||| . .|.  ..|..| | ||.|  ||. |||.    |.|.  .  ... .      | ..||||| ||||.|. .. ..
aygvltvslkk.keefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkni.inrsphvsesgpwiihcsagvgrtgiflvidaml

SRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMV
 . .|. ..|... |  . ..||...|   |. | . ...
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 306-372 1.3e-12 42.2 In-house 30-98 (297) alignment
Range on Protein: 306-372
Range on HMM: 30-98/297.0
QN--KDKNRIGHILPFDKNVVKLERLIGEefSDYINASFITGYQR--KNMYIATQGPLPNTIADFWRMIWE
.|    |||  .|| .|.. ||| | | |  .||||| ...  .   .  || .|||| .|. |||....|
rnsslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvae

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 306-371 1.9e-11 38.3 In-house 46-125 (350) alignment
Range on Protein: 306-371
Range on HMM: 46-125/350.0
QNKDKNRIGHILPFDKNVVKLER--------LIGEEFSDYINASFITGY-----QRKNM-YIATQGPLPNTIADFWRMIW
.   |||   |||.... |||..            . .|||||...        .  .  |||||.|||.|. ||...| 
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvil

Y_phosphatase Protein-tyrosine phosphatase 307-524 4.5e-68 224.5 Pfam-A 1-235 (235) alignment
Range on Protein: 307-524
Range on HMM: 1-235/235.0
NKDKNRIGHILPFDKNVVKLerlIGEEF-SDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLEIDETEE
||.|||  .|||.||. |||    |.|  ||||||....||..|...|||||||..||.|||||.|.                   |||||| | .|...
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

QGDISVTLV-EESEEDDDFTVRDIEISHAHMKD-IRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkEQGPKPIVVHCSAGSGRTGVFIALNVLMSR
 |||.|.|. .|.|.....|.|..|...   ..  |...|.|. .||. |||||  .|..|..| . .. |.  .|.|||||||.||||.|.||..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

MEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
.|.|. .||.|.|. ||.|||.|||.|.|..|.| |..|
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 307-524 4.5e-68 224.5 In-house 1-235 (235) alignment
Range on Protein: 307-524
Range on HMM: 1-235/235.0
NKDKNRIGHILPFDKNVVKLerlIGEEF-SDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWE------------------MCAQYWPLEIDETEE
||.|||  .|||.||. |||    |.|  ||||||....||..|...|||||||..||.|||||.|.                   |||||| | .|...
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

QGDISVTLV-EESEEDDDFTVRDIEISHAHMKD-IRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkEQGPKPIVVHCSAGSGRTGVFIALNVLMSR
 |||.|.|. .|.|.....|.|..|...   ..  |...|.|. .||. |||||  .|..|..| . .. |.  .|.|||||||.||||.|.||..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

MEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
.|.|. .||.|.|. ||.|||.|||.|.|..|.| |..|
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

0041856 (Phosphotyrosine protein) phosphatases II 307-529 1.5e-41 137.4 In-house 1-174 (182) alignment
Range on Protein: 307-529
Range on HMM: 1-174/182.0
NKDKNRIGHILPFDKNVvklerligeeFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM---------CAQYWPleideteeqgdisvtlve
|.||||  .|||.| .           ..|||||... |... . .|||||||..|.|||.||..|.         . .|||                  
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywp..................

eseedD-DftvrdieishahmkdIRKIRQYHFRGWPEVGVPEsgidLMRLVNKSH---LhqkeqGPKPIVVHCSAGSGRTGVFIALNVLMSRmeeesMID
     .                  | . ||.. .||  |||.    |  |..  .          ..|..|||||| ||||...|. .....      ..
.....ell...............erlgiqylylpwpDhgvpd....ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvs

VFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQ
....|. .|..||.||. . |. |.. |. |.|. .
leeavklvrsrRpgmvitpnqyfflqlallellllk

subfamily_CG42327_pd Subfamily CG42327 307-372 1.1e-12 42.3 In-house 28-94 (319) alignment
Range on Protein: 307-372
Range on HMM: 28-94/319.0
NKDKNRIGHILPFDKNVVKLERLIGEEFSDYINASFITGYQR-KNMYIATQGPLPNTIADFWRMIWE
 |||.|. ...|. .  | |.|   .. . |..||.. ||.  .| |||.| .| .. .||||..||
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvwe

0044763 (Phosphotyrosine protein) phosphatases II 318-526 8.3e-28 92.6 In-house 1-171 (178) alignment
Range on Protein: 318-526
Range on HMM: 1-171/178.0
PFDKNVVKLERLIGEEFSDYINASFITGYqrknMYIATQGPlpntiADFWRMIWEMC------------------AQYWPLEIDeteeqgdisvtlvees
|.| ..|.|. | |.| |||||||.|...    .|.....|     ||......|.                    .||| | .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

eedddftvrdieishahmkdirkiRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGpKPIVVHCSAGSGRTGVFIALNVLMSRmeeeSMiDVFQTVR
                         ||.. ..|  |||..   ....|.  . ...|.| .|..|||||| ||.|...|.  ....    .. .... ..
........................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaie

GLRQQRPhMVQDLAQFKFCYSAMVEYL
 .|..|| .|.   | ...|    ..|
lvrerRp.ivpnpgqlrqLyefelrll

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 328-432 6.5e-07 23.7 In-house 9-122 (130) alignment
Range on Protein: 328-432
Range on HMM: 9-122/130.0
RLIgeeFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEMC-------------AQYWPLEIDETEEQGDISVTLVEEsEEDDDFTVRDIEISH
||      .||||||.   .| . |. || || .|  |||.|. |                .|||        . || ||| .  .| .      .||..
rlq...gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyeediivtltdr.defknikasnleies

AHMKDIRKIRQYHFRGWP
  ..  . .  ..   ||
dlneshqaltmfqisnwp

0046846 (Phosphotyrosine protein) phosphatases II 329-527 1e-35 118.4 In-house 6-174 (176) alignment
Range on Protein: 329-527
Range on HMM: 6-174/176.0
LIGEEFSDYINASFITGYqrknMYIATQGPLPNTIADFWRMIWEM------------------CAQYWPLEIDETEeqgdisvtlveeseedddftvrdi
|. ....|||||..| |.    ..||||||||.|.|||..|..|.                  |..|||.. ..                          
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

eishahmkdirkirQYHFRGWPEVGVPESgIDLMRLVNKSHLHQKEQgpKPIVVHCSAGSGRTGVFIALNvlmsRMEEESMIDVFQTVRGLRQQRP-HMV
              ||.. .||. |||..  .|..|..  . ..||   .|..|||||| ||||...|.      .| |  ..|..... .|.||| ..|
..............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QDLAQFKFCYSAMVEYLE
|  .| .|.| .. ..|.
qtpeQyrflyefellllk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 330-373 9.2e-09 29.3 In-house 65-108 (347) alignment
Range on Protein: 330-373
Range on HMM: 65-108/347.0
IGEEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEM
  ..   ||||| |   . .. || || |||.|. |||.|.  .
raddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvt

0043147 (Phosphotyrosine protein) phosphatases II 332-519 1.4e-36 121.2 In-house 2-154 (172) alignment
Range on Protein: 332-519
Range on HMM: 2-154/172.0
EEFSDYINASFITGYQRKNMYIATQGPLPNTIADFWRMIWEMCAQYWPLEIDEteeqgdisvtlveeseedddftvrdieiSHAHMKDIRKIRQYHFRGW
.|.|||||||.. .|   . .|||||||.||.||||||..|.  ...    ..                             .   .  | . ||.. .|
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................lydpellerlgiqylylpw

PEVGVPeSGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMsrmeeeS-MiDVFQTVRGLRQQRPHMVQDLAQFKFCY
|  ||| .   |.....  . .. ..  .|..|||||| ||||...|.  ..        . .....|. .|..||..||   | .|.|
pDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrfly

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 333-370 1.6e-06 21.7 In-house 88-127 (349) alignment
Range on Protein: 333-370
Range on HMM: 88-127/349.0
EFSDYINASFI--TGYQRKNMYIATQGPLPNTIADFWRMI
   ||||| ..  | .. .. ||||| ||| |. ||...|
klddyinanylkltrisvekkyiatqaPlPstvddfykvi

0051429 (Phosphotyrosine protein) phosphatases II 334-528 2e-44 147.6 In-house 3-227 (272) alignment
Range on Protein: 334-528
Range on HMM: 3-227/272.0
FSDYINASFITGYQR---KNMYIATQGPLPNTIADFWRMiWEM------------------CAQYWP----------LEIDETEEQGDISVTLVEESEED
.|.||||... || |   ........||||.|.|||||. .|.                  | .|||           . ..| ..|...|||..|.  .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DdFTVRDIEISHA-HMKDIRKIRQYHFRGWPEVGVP-ESGIDLMRLVNKshlhqkeqgPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMID-------
| ...| .....  .....|.....|...||  ||| |. ..|..|...         ..|..|||||| .|||...||  |. ....| ..|       
d.yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
 ....|. ||.|||..||. .|..|.| |..|.|..
yleeaveelraqrpgavqteeqylflyeallellrs

0051082 (Phosphotyrosine protein) phosphatases II 334-522 1e-26 88.8 In-house 2-149 (151) alignment
Range on Protein: 334-522
Range on HMM: 2-149/151.0
FSDYINASFITGYqrknmYIATQGPLPntiaDFWRMIWE----------------MCAQYWPLEIdeteeqgdisvtlveeseedddftvrdieishahm
.|||||.|..||.     .....|||.    ||.....|                .|..|.| .                                    
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...................................

kdiRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLhqkeQGPKPIVVHCSAGSGRTGVFIALNVLMSRmeeesmIDVFQTVRGLRQQRPHMVQDLAQFKF
   ........ .||. |.|.|   .......       ....|..|||||| ||||...||  .. .      ........ .|..||..||   || |
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

CYSAM
.. |.
qlfal

0036282 (Phosphotyrosine protein) phosphatases II 335-519 9.1e-38 125.0 In-house 2-163 (174) alignment
Range on Protein: 335-519
Range on HMM: 2-163/174.0
SDYINASFITGYQRKNMYIATQGPLPntiadFWRMIWE------------------MCAQYWPLeideteeqgdisvtlveeseedddftvrdieishAH
|||||||.. .. . . .||.||||.     ||.|..|                  .| .|||                                    .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lr

MKDIRKIRQYHFRGWPEVGVPESGIdLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEeESMIDVFQTVRGLRQQRPHMVQDLAQFK
    | . ||.. .||  |||.. | | ..|.  . ...| . .|..|||||| ||||...|.  .. ... ||..|....|| ||.|||.|||   |..
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FCY
|.|
fly

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 337-517 1.8e-23 77.7 In-house 77-272 (301) alignment
Range on Protein: 337-517
Range on HMM: 77-272/301.0
YINASFITGYQRKNMYIATQGPLPNTIADFWRMIW------------------EMCAQYWPLEIDETEEQGDISVTLVEESE-EDDDFTVRDIEISHAHM
 | | .|    . . .|||||||.||  ||| |.                   |.|..| |..| |. . |  .......    ... . | .|.  .  
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

K-DIRKIRQYHFRGWPEVGVPESGIDLMRLVNkshLHQKEQgpKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFK
| . | .  | .  |.. |||.| ..|. |..   | .| .  |||||||||| ||.  ||. ..| ...| .  |.. .... ||..| . ||   |. 
kfatrtvthyqysewtdrgvPkshaelfdlme...lvkkse..kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly

F
.
w

0049260 (Phosphotyrosine protein) phosphatases II 342-519 1.1e-32 108.2 In-house 1-143 (152) alignment
Range on Protein: 342-519
Range on HMM: 1-143/152.0
FITGYQRKNMYIATQGPLPNTIADFWRMIWEM------------------CAQYWpleideteeqgdisvtlveeseedddftvrdieishahmkdirki
|| || .....||||||.|||.||||||..|.                  |.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

rQYHFRGWPEVGVPESGIDLMRLVNKSHLHqKEQGPKPIVVHCSAGSGRTGVFIALNVLMsrmeeeSMIDVFQTVRGLRQQRPHMVQDLAQFKFCY
 ||..  ||  |||.. . |. |.   . . ...  .|..|||||| ||||...|.  ..        ......|. .|..||..|.   | .|.|
.qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 344-372 3.7e-06 20.5 In-house 230-258 (440) alignment
Range on Protein: 344-372
Range on HMM: 230-258/440.0
TGYQRKNMYIATQGPLPNTIADFWRMIWE
 || .|| .|||| ||  |. ||||.. .
egyskknafiatqmpldstvldfwrlvhd

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 349-373 7.7e-06 20.2 In-house 4-28 (199) alignment
Range on Protein: 349-373
Range on HMM: 4-28/199.0
KNMYIATQGPLPNTIADFWRMIWEM
.  ||||| || .|.||||.|.|| 
qrryiatqhplretmadfwqmvwet

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 350-373 9.1e-06 20.0 In-house 4-27 (198) alignment
Range on Protein: 350-373
Range on HMM: 4-27/198.0
NMYIATQGPLPNTIADFWRMIWEM
  ||||| || .|.||||.|.|| 
rryiatqhplretladfwqmvwet

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 363-532 4.6e-17 56.9 In-house 59-230 (255) alignment
Range on Protein: 363-532
Range on HMM: 59-230/255.0
IADFWRMIWEMCAQYWPLEIDETEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKShlhQKEqgpKPI
..||     | | .|.||| ||     |..||  . |  |  .  ..|    .. |  .... |...||.|   ||   ... ..      ..    |..
lcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvv...rds...ksv

VVHCSAGSGRTGVFIALNVLMS----RM--EEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL---EEQSTE
|||||.| ||.  |.  ...       .   |   .|  . .. ||..|.  ...  |. |.   .....   .|   .
vvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleak

subfamily_hpo-7_pd Subfamily hpo-7 363-527 2.5e-15 51.1 In-house 65-228 (263) alignment
Range on Protein: 363-527
Range on HMM: 65-228/263.0
IADFWRMIWEMCAQYWPLEIDETEEQGDISVTLVEESEeddDFTVRDIEISH--AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKShlhQKEqgpK
..||     | | .|.||| ||     ...|.  .  .   |  .. .|.     . | ......| ..||.|.  ||  .. .....     ..    |
LcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkva...rns...k

PIVVHCSAGSGRTGVFIALNVLMS----RM--EEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
..|||||.| ||.  |   ...       .   .   .|  . .. ||..|.  ...  |. |    ..... 
slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl

PTEN_1 370-502 1.6e-07 26.3 In-house 30-171 (196) alignment
Range on Protein: 370-502
Range on HMM: 30-171/196.0
IWEMCAQYWPL--EIDETEEQGDISVT--LVEESEEDDDFTVRDIE-ISHAhM------KD-IRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQ
|.  .|   ||  ||||.  .| ..    .... .||. ..| . . ...  .      .. ...  .|. ....  |.|     .  ...  .  .. .
iamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeel.sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdp

GPKPIVVHCSAGSGRTGVFIALnVLMSRMEeESMIDVFQTVRGLR
  . ..||| || ||.|. .|   ||...   .. . .. ||  |
ngnvVlVHCkaGlgRsGtvvaa.yLmykgk.ltadeAlelvrekR

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 372-528 6.3e-13 43.5 In-house 111-261 (290) alignment
Range on Protein: 372-528
Range on HMM: 111-261/290.0
EMCAQYWPLEIDETEEQGDISVTLvEESEEDDDFTVRDIEISHAHMKDIrKIRQYHFRGWPEVGVPESGIDLMRLVNKSHlhQKEqgpKPIVVHCSAGSG
. ||.| | ...|    ....|    . |..||. .| ... .   ..  ..  . ..|| .. |.|. . |. |..| .  ...    |..|||  |  
faCakYvpesvgeelkfkgltvkC.kskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvk..ask...tpvivHcvdGiS

RTGVFIALNVLMSRME-EESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
|  .. |... .  .   .. . . . .  ||.|| .....  .. |   ..| .. |
rsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaie

subfamily_CG42327_pd Subfamily CG42327 372-450 8.7e-08 26.2 In-house 112-190 (319) alignment
Range on Protein: 372-450
Range on HMM: 112-190/319.0
EMCAQYWPLE--IDETEEQGDISVTLVEeSEEDDDFTVRDIEISHAHMKDIRKIRQYHFrGWPEVGVPESGIDLMRLVNKS
..||.|.| .   |.|.  ||| ||| .  | .| . .  . . . . .  |..  | .  |.| .|| .   |. .. . 
kvcaeylPtketldntslyGdilvtlkg.revkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev

subfamily_PTPRA_pd Subfamily PTPRA 373-532 1.9e-49 163.4 In-house 142-301 (330) alignment
Range on Protein: 373-532
Range on HMM: 142-301/330.0
MCAQYWPLEidETEEQGDISVTlVEESEEDDDFTVRDIEIS----HAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPkPIVVHCSA
 |||||| |   .   |.| |. ||....  |.|||.. .     ... |. | .||.||..||.||||  .| ...|..| .  .. ..  ||||||||
kcaqywPde..GlvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsa

GSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTE
| |||| ||.|. .. |.. | ..|||..|. ||.|||.||| . |..|.| .. ||     ||
GvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdte

subfamily_Ptp69D_pd Subfamily Ptp69D 373-531 2.3e-47 156.6 In-house 132-291 (307) alignment
Range on Protein: 373-531
Range on HMM: 132-291/307.0
MCAQYWPLEidETEEQGDISVTLVEESEeDDDFTVRDIEISHAH-----MKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQgPKPIVVHCS
 ||.||| |  .. . ||| |.||.|..  .|.. |....|. .     ..| ||. |||. ||... |||.   |..|... . ..| .   |||||||
kcakYWpie..devqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCs

AGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQST
||.||.|.|.||..|. ....|  .|.|.||..||.||. .|| |.|..|.| |...| .   |
aGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdt

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 373-525 7.6e-22 72.3 In-house 135-282 (290) alignment
Range on Protein: 373-525
Range on HMM: 135-282/290.0
MCAQYWPLEIDETEEQGDISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKshlhqKEQGPKPIVVHCSAGSGR
 |.||.| .  |.   |.|.|.  ||...|..   . . . . .     |.. .. . ||.  |. | . |.|..         . . |.||||||| ||
kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlri.....lrkasGpvvvhcsaGiGr

TGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
|| |.|..| .  . .   .|. ..|| ||. |   ||   |.     .....
tGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 373-446 2.5e-08 28.1 In-house 117-189 (297) alignment
Range on Protein: 373-446
Range on HMM: 117-189/297.0
MCAQYWPLEIDETEEQGDISVTLVEESEEDdDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRL
 || |||   .|  . ||. |  . .  ..   .|   |.   . .. |..|   | .||. |||    || |.
kcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 374-533 1.2e-51 170.7 In-house 131-287 (318) alignment
Range on Protein: 374-533
Range on HMM: 131-287/318.0
CAQYWPLeiDETEEQGDISVTLVEESEeDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRT
...|||   ..... |.. |.| || |  .|...| ..... .... |..||||.  ||. |||||| .|. || ...  |...| .||||||||| |||
vhryWPs..kgsrsygklvvelkeeve.lsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrt

GVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEY
|||||...|. |...|...||||||. ||.||. |||   |..|.| ...|.|.   || 
GvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev

subfamily_PTPN13_pd Subfamily PTPN13 374-527 1.8e-36 120.9 In-house 119-270 (273) alignment
Range on Protein: 374-527
Range on HMM: 119-270/273.0
CAQYWPLEIDETEEQGD-ISVTLVEESeEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGpkPIVVHCSAGSGR
| .||| . ...    . . |.|..   . |.|.||...... . .. |.. . .|  ||. ||| |  .|...| .    |...|  ||||||||| ||
chrywPesknkklkvsnrlevellkvq.kldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdag..PivvhcsaGiGr

TGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
.|..|...|..  .| .  .|| ..|| ||.||  .||   |. |.| |..| |.
sGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_PTPN14_pd Subfamily PTPN14 374-528 3.3e-27 90.3 In-house 135-298 (300) alignment
Range on Protein: 374-528
Range on HMM: 135-298/300.0
CAQYWPLEI--DETEEQGDISVTlVEESEEDDDFTVRDIEISHAHMKDIRKIRQYHFRGWPEVGVPES---GIDLMRLVNKSHLHQKEQG-----PKPIV
. .|.| .    .| | |   ||  . ||. | .. . ... |   |. |..    .  ||. ||||     .. .. |.    . ...        |..
sfkyfPkleskkktvefgkfkvt.tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEE
|||||| ||||| |  ..|.. .| .  ||. .... ||.|| ..|| |||.|| |.....||..
vhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 374-517 6e-12 39.6 In-house 133-279 (302) alignment
Range on Protein: 374-517
Range on HMM: 133-279/302.0
CAQYWPLEIDETEEQGDISVTLVEESE------EDDDFTVRDIEISHAHMKD--IRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkeqgpKPIVVH
||.|.  ..... . |  .|. |.  .      .  .|..  .||   ..|.   . .   .| .||. | |.     . ...    ..     | ..||
caeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesyk.....knvlvh

CSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKF
|||| |||| ..|.   .    .. . |. . |  .|| |   |||  |  .
csaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

0048076 (Phosphotyrosine protein) phosphatases II 376-524 4.9e-22 73.6 In-house 1-141 (145) alignment
Range on Protein: 376-524
Range on HMM: 1-141/145.0
QYWPLEIDETEEQGDISVTL-VEESEEDDDFTVRDIeiSHAHM--KdiRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQgpKPIVVHCSAGSGR
.||| ||..    |.. ..| .|. .. .  || ..  ..     .  |.. ||.. .||  |||..  .|.....  . ..||   .|..|||||| ||
pywpseilpglylgslptaldlellkdlgittvlnl..tselelle..rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgR

TGVFIALNVLMSrmeeESmIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVE
||...|. ....    .. ........ .|.|||..|.   |..|.| .  |
tgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefele

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 376-520 1.6e-16 55.1 In-house 49-198 (199) alignment
Range on Protein: 376-520
Range on HMM: 49-198/199.0
QYWPLEIDETEEQGDISVTLVEESeEDDDFTVRDIEISH--AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQG--PKPIVVHCSAGSG
 |||     | . | .|||    .    |.|.  . ..   .     |.| .| |  | |   |.  . .  .|    . .| .     |..|||| | |
fywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqg

RTGVFIALNVLMSRMEE--ESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYS
 ||||.||.. .   ||   |..|.|.  . ||| |  ..  | ...| | 
ftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 376-520 1.6e-16 55.1 In-house 48-197 (198) alignment
Range on Protein: 376-520
Range on HMM: 48-197/198.0
QYWPLEIDETEEQGDISVTLVEESeEDDDFTVRDIEISH--AHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQG--PKPIVVHCSAGSG
 |||     | . | .|||    .    |.|.  . ..   .     |.| .| |  | |   |.  . .  .|    . .| .     |..|||| | |
fywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqg

RTGVFIALNVLMSRMEE--ESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYS
 ||||.||.. .   ||   |..|.|.  . ||| |  ..  | ...| | 
ftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_ptpA1_pd Subfamily ptpA1 386-487 3.2e-11 37.6 In-house 152-257 (418) alignment
Range on Protein: 386-487
Range on HMM: 152-257/418.0
EEQGDISVTLVEESEED-DDFTVRDIEIshAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQG-----PKPIVVHCSAGSGRTGVFIAL
|  |  || |||  ..   .   |.| .  .   . | | ||.. |||.  .|.    . .|.     .|..         ||.|||||| |||| | . 
evfgtysvelveviqdpereiitrnirl..tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfcta

NVLMSRME
 ..| ...
vimmkkld

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 391-526 1.8e-10 35.0 In-house 143-279 (303) alignment
Range on Protein: 391-526
Range on HMM: 143-279/303.0
ISVTLVEESEEDDDFTVRDIEISHAHMKDIRKIrqYHFRGWPEVGVPESGI-DLMRLV-NKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNV-LMSRME
| |    . |  | .... . .|  . | . ..  .|.. ||   .|  |   ... . .   . .|    .| |    .| ||.| |  ..   .|  .
irvgefkrvelgdgwvlkvlsvsngdyksflhv..hhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhs

EESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|.. .|. . .  .|. | | ||.|.|| . |. . |..
eqasldlvkclenvrngrlhavqnlsqfsvvytllaehv

0048179 (Phosphotyrosine protein) phosphatases II 407-520 5.6e-21 70.2 In-house 33-139 (144) alignment
Range on Protein: 407-520
Range on HMM: 33-139/144.0
VRDIEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKeQGpKPIVVHCSAGSGRTGVFIALNVLMsrmeEESmIDVFQTVRGLRQQRP
| ..  .. .   .| . ||.. .||  |||..  .| ....  . ... .| .|..|||||| ||||...|. ...    ..  ........ .|..||
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrp

HMVQDLAQFKFCYS
..|.   |..|.. 
gavpnpgqlrfLle

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 409-529 3.1e-18 60.6 In-house 175-290 (305) alignment
Range on Protein: 409-529
Range on HMM: 175-290/305.0
DIEISHAhMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQkeqGpkPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVF-QTVRGLRQQRPH
 . |  .  .. ||. .||.  ||. ||| . . .. |..|.   .   |  ||||||||| ||||  . |. .. .. .  .|.   . .. .|.||  
vlviegp.gekarkvthyhwidwpdrgvpaadlailellekarpsk...g..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnn

MVQDLAQFKFCYSAMVEYLEEQ
 .|  ||. | .  ...|....
siqtdaqylfvhqvilnyfrkk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 410-526 3.7e-23 76.6 In-house 78-194 (440) alignment
Range on Protein: 410-526
Range on HMM: 78-194/440.0
IEISHAHMKDIRKIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMV
|. |.    . | ..|||..|||. |||.    ......     |.. |  |..||||||.||||| ||.. ..   .    ||.|  .  .|..||.||
inasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmv

QDLAQFKFCYSAMVEYL
|   |. | . |..| |
qtpeqyafvheavlegl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 422-526 1.1e-18 62.1 In-house 216-344 (350) alignment
Range on Protein: 422-526
Range on HMM: 216-344/350.0
KIRQYHFRGWPEVG---VPESGIDLMR----L--VNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSR------MEEES-MID--------VFQT
 . | ... |....    ||| .  .     |   . ...| ...  .||.|||||| ||||....|. |.|       ...||  .|        ....
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|  ||.||  |||.| || |.| |.  | 
vnelrkqrismvqnldqfifiYeallfyf

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 422-527 5.4e-06 19.2 In-house 206-310 (346) alignment
Range on Protein: 422-527
Range on HMM: 206-310/346.0
KIRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGpKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSA
  . .|   |  .  |   . ..... . .  .. |    . |    |.||.  ||     . ....    .... .. ..||||  |. .||.   |. 
icqvhhhapwkhlqqppktlpiikmihqflsekqvqn.agvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai

MVEYLE
...|. 
vfdyia

PTPc_DSPc_SM00012 423-523 1.5e-34 113.7 In-house 2-104 (105) alignment
Range on Protein: 423-523
Range on HMM: 2-104/105.0
IRQYHFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGP-KPIVVHCSAGSGRTGVFIALNVLMSRMEEE-SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYS
...||. |||. ||||.. ....|... . ......  ||.||||||| ||||.|.|| .|....|.| . .|.||.|. ||.|||.||| ..|. |.| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AMV
|. 
all

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 426-531 2.1e-15 50.9 In-house 186-290 (302) alignment
Range on Protein: 426-531
Range on HMM: 186-290/302.0
YHFRGWPEVGVPESGIDLMRLVNKShLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
|..  |..  ||..  .|.. . |   ..|... ...|.    |.|| |.|..| | ........   . ..|. .|.|||..|. | |. . | |.. |
yvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly

LEEQST
. .. |
ikkkvt

0038934 (Phosphotyrosine protein) phosphatases II 427-519 3e-10 35.6 In-house 83-170 (194) alignment
Range on Protein: 427-519
Range on HMM: 83-170/194.0
HFRGWPEVGVPESGIDLMRLVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRmeeeSMiDVFQTVRGLRQQRPHMVQDLAQFKFCY
.   .|. |.. |   |.| ..  . . .|. .. ..||| || ||||...|   ....     | .. . .. .|. ||....   ...  .
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrl....gm.saeeAialfrekRpgaipnqdyleall

subfamily_PTPDC1_pd Subfamily PTPDC1 430-520 4.2e-09 31.1 In-house 89-170 (182) alignment
Range on Protein: 430-520
Range on HMM: 89-170/182.0
GWPEVGVP--ESGIDLMRLVNKSHLHQKeqgpkpIVVHCSAGSGRTGVFIALNVLMSRMeeesmIDVFQTVRGLRQQRPHMVQDLAQFKFCYS
||.. ||.  |. .|....|. .  ..|      . ||| || ||||| ||  .. ..      ..  .... .|..||. .|   | ...  
gwkDygvasleriLdivkvvafalqegk......vavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke

subfamily_PTEN_pd Subfamily PTEN 446-500 1.3e-06 23.5 In-house 101-157 (184) alignment
Range on Protein: 446-500
Range on HMM: 101-157/184.0
LVNKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEES--MIDVFQTVRG
.|.. . . .|.  . .|||| || ||||| |.  .| |.. |..  ....|...| 
ivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 448-527 1.9e-15 51.0 In-house 254-345 (349) alignment
Range on Protein: 448-527
Range on HMM: 254-345/349.0
NKSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVLMS--RMEE--ESMID--------VFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLE
. ..|. ...   ...|||||| |||||.. |..|.|   . .     |.        .. .|  ||.||  |||.|||| ..| |...|. 
lfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa

subfamily_DSP11_pd Subfamily DSP11 449-514 1.7e-06 22.1 In-house 106-172 (178) alignment
Range on Protein: 449-514
Range on HMM: 106-172/178.0
KSHLHQKEQGPKPIVVHCSAGSGRTGVFIALNVL-MSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQ
|..|.....  | | |||  |  ||| .|   .. .  .| |  |..|...||   .| . ..|| .
kefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkk

0048567 (Phosphotyrosine protein) phosphatases II 450-499 5e-06 21.0 In-house 65-118 (157) alignment
Range on Protein: 450-499
Range on HMM: 65-118/157.0
SHLHQKEQGPKPIVVHCSAGS---GRTGVFIAL-NVLMSRMEEESMIDVFQTVR
. |.. |  .|.|.|||.||    |||...|..  .|  ..  |  |. .. ||
kflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr

DSPc Dual specificity phosphatase, catalytic domain 450-511 6.5e-06 21.0 Pfam-A 64-120 (133) alignment
Range on Protein: 450-511
Range on HMM: 64-120/133.0
SHLHQKEQGPKPIVVHCSAGSGRTGVFIALnVLMSRMEEeSMIDVFQTVrglRQQRPHMVQD
. ... ||  | ..||| ||  |.. .|.   ||....  |. . .. |   ...|..... 
efiekaeqkgkkvlVHCqaGisRSatliia.Ylmktknl.slneAyefv...kerrskispn

DSPc Dual specificity phosphatase, catalytic domain 450-511 6.5e-06 21.0 In-house 64-120 (133) alignment
Range on Protein: 450-511
Range on HMM: 64-120/133.0
SHLHQKEQGPKPIVVHCSAGSGRTGVFIALnVLMSRMEEeSMIDVFQTVrglRQQRPHMVQD
. ... ||  | ..||| ||  |.. .|.   ||....  |. . .. |   ...|..... 
efiekaeqkgkkvlVHCqaGisRSatliia.Ylmktknl.slneAyefv...kerrskispn

subfamily_CG42327_pd Subfamily CG42327 452-525 1.5e-16 55.0 In-house 242-314 (319) alignment
Range on Protein: 452-525
Range on HMM: 242-314/319.0
LHQKEQGpkPIVVHCSAGSGRTGVFIALNVLMSRMEEE-SMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
 ....||  |.||||| | ||||. || .. . ..||    .|. |.|  .|..| . |..  |..| |  . ||
gtresqG..PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

Y_phosphatase3 Tyrosine phosphatase family 454-492 3.3e-06 22.2 Pfam-A 119-157 (164) alignment
Range on Protein: 454-492
Range on HMM: 119-157/164.0
QKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMI
.  . ..|...||.||  ||||..||   .  ..|| ..
alaeeegpvlfHCtaGKDRTGvvaalllsllgvdeetia

subfamily_PRL_pd Subfamily PRL 454-498 8.2e-06 20.0 In-house 85-129 (151) alignment
Range on Protein: 454-498
Range on HMM: 85-129/151.0
QKEQGPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTV
 ||.. . . ||| || ||. |..|| .. . |. |  ... .. 
fkeepkstvavhcvaGlGraPvlvalalieaGmkyedavefirek

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 458-525 2.3e-15 51.2 In-house 227-294 (297) alignment
Range on Protein: 458-525
Range on HMM: 227-294/297.0
GPKPIVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEY
 . ...|||||| ||.|| .  .|.....  . . ||   .. ||.||. .|| | ||...|.|... 
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk

subfamily_eak_pd Subfamily eak 460-536 4e-07 23.7 In-house 238-315 (332) alignment
Range on Protein: 460-536
Range on HMM: 238-315/332.0
KPIvVHCSAGSGRTGVFIALNVLMSRMEE--ESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYLEEQSTEYQNF
 || . .. || |.|||. ...|.  ...  . .  | . .   ...| | |    |  | | ....||  .  .....
api.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 462-526 2e-17 57.4 In-house 1-65 (69) alignment
Range on Protein: 462-526
Range on HMM: 1-65/69.0
IVVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
.|||||.|.|||| |||. | |.|.  | ..|.|  |. .|. || || .  .. | . |.|| |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 463-526 4.6e-17 56.1 In-house 1-64 (69) alignment
Range on Protein: 463-526
Range on HMM: 1-64/69.0
VVHCSAGSGRTGVFIALNVLMSRMEEESMIDVFQTVRGLRQQRPHMVQDLAQFKFCYSAMVEYL
|||||.|.|||| |||. | |.|.  | ..|.|  |. .|. || || .  .. | . |.|| |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal