Gene SpurPTPRB-like-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTPRB-like
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP112_AA protein Get Run
SpurP112_AA_81-358 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 72-358 1.6e-91 302.1 In-house 19-299 (308) alignment
Range on Protein: 72-358
Range on HMM: 19-299/308.0
ATTHSRPSKKIMFAQHVAKmsARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLkgEVGNDYINASYIADD--QGNRKYIATQ
 ...| .   . ..... |  | .. ... |.. |...  ..  .||.  .| ||||...|||||..|| |  . |.|||||||.       .||.||||
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatq

GPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTG--QKPHLHGNVTVTLVGSKQTEHFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPA
||||||...|| |||| . ..|||.| ||| |. ||..|||.   ...  .|..||||.  .. .....||| . .  .| ..||||..|..| ||||| 
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

STAPLVALLYQVKMTSQEdgaltGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
|...|...| .|. . ..     |||.||||||.||||||||.|.|.. ...      .|. ..|.||||||   |||. ||..|.|..| ..
speilldflelvrkslpg.....gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleyl

subfamily_PTPRB_pd Subfamily PTPRB 74-359 1.7e-120 396.5 In-house 2-286 (293) alignment
Range on Protein: 74-359
Range on HMM: 2-286/293.0
THSRPSKKIMFAQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQG
..|.| |. .|..||.||.|... .||.||..| |..| .||..|..|.|..|||..||||||..||.|   |.| |.|||||.|| . . .|..|||||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPL
|||.|.|.||.||||.|.|.|||.|.|||.||.|||.|||. ..|.|.|...|||| ....|... |.|.| |. .| .|..|....|.||||| .|..|
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

VALLYQVKmTSQEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
......|. ...|. | ..||.||||||.|||||||| |.|..||..   .||.||.|.||.|||.|..||||  |||..|. .|.|..
ldfvrtvr.eaiektaskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcvldllr

0045450 (Phosphotyrosine protein) phosphatases II 75-358 2.7e-84 278.8 In-house 5-304 (307) alignment
Range on Protein: 75-358
Range on HMM: 5-304/307.0
HSRPSKKIMFAQHVAKMSARNNDGFSDEYNSLPAMEK--IRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG----NDYINASYI--------ADDQ
.|.. .  .. ..|... . .. |.  |...|. ...  .   ..|.   | ||||...|||||..||.|. . |    .|||||||.            
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

GNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG---KKGTELTVTHYQYLA
 .||.||||||||.|...||.|.|| . ..|||.| ||| |. || .|||. . .  .||.||||.. .. .... ||| .    ..| ..||||..|..
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WTDHGVPASTAPLVALLYQVKMTSQEDgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
| ||||| |...|.... .|.   .|.    ||..||||||.|||||||||....  ...   . ..|.  .|..|||||   ||.. ||..|....| |
wpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

I
.
l

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 77-359 2.4e-136 448.5 In-house 7-280 (288) alignment
Range on Protein: 77-359
Range on HMM: 7-280/288.0
RPSkkimfaQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIADDQGNRKYIATQGPLP
.|       ..|||.||||..|||.|||||.|.|| ..||..|.|.|..|||.|||||||..||.||.   | |.||||||||.......|||||||||.
spv......akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPla

NTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVAL
.|...|||.|.|.|.|||||.|.||||||||||.|||...||...|.||||||.||..|.|..|.||..||.|||..|.||||||.|||||.|.|||..|
dtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllel

LYQVKMTSQEDgalTGPIIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
|.|||...|.|   |||||||||||.||||||||.|.|..|...   .||||.||||||||.||..|||||.||.......|||||
lrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllslie

0039614 (Phosphotyrosine protein) phosphatases II 77-358 1.2e-83 276.3 In-house 12-289 (297) alignment
Range on Protein: 77-358
Range on HMM: 12-289/297.0
RPSKKIMFAQHVAKMSARNNDGFSDEYNSLPAMEKIraVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG----NDYINASYIADDQG-NRKYIATQGP
 | .  ...... .. | .. ..  |. .|. .      ..|.   | ||||...|||||..||.||.| |    .|||||||.      .||.||||||
ipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP

LPNTIDHFWEMVWETKASTIVMMTALVEGGKtKCEHYWPTGQKphLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLV
||.|...||.|||| . ..|||.| ||| |. ||..|||. .    .|..||||.. .. .....||| . ..| ..||||.||. | ||||| |.. | 
lpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelll

ALLYQVKMTSQEDgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
 .| .|.   .|.    ||..||||||.|||||||||..... ...      .|.  .|..|||||   |||. ||..|....| |.
eflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallell

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 78-358 5.4e-77 254.0 In-house 8-290 (298) alignment
Range on Protein: 78-358
Range on HMM: 8-290/298.0
PSKKIMFAQHVAKMSARNNDGFSDEYNSLPAMEK---IRAVTVARNARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIADDQGNRKYIATQGP
.. |... . .|.. . .  |...|.. | ....       .|||. .| .|||. .|...|. || |.    .   ||||||..   .|.  .||||.|
edlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaP

LPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKG--TELTVTHYQYLAWTDHGVPASTAP
|..|.  || ||.| ...||||.| |.| .|||...|||. .. . .|..||.|  ...   .|.|.| . ||   .| .| . ..  |.|.|||. .  
ltetvedFWrmvteedigtiVmltnleeldktkyhkywPd.egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenats

LVALLYQVKMTSQEDGalTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
...|| .|... |. |    |.||.||||.||.||||| | ... ....     .|.  .|  ||..|. .|||  ||.... ..|  .
vldllrkvrasqqqag..nkpvivqCsaGvgRsGtfiaidsvlervkke...qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 79-170 1.1e-14 48.3 In-house 5-95 (95) alignment
Range on Protein: 79-170
Range on HMM: 5-95/95.0
SKKIMFAQHVAKMSARNNDGFSDEYNSLPaMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGNDYINASYIADDQGNRKYIATQG
 .  .|  || .| .  .. | .|..|.. |    . ||     |  |||| ||.|||  || |      ||||| ..     .  |||.||
ihvsvfhshvlemhsnsdqefdnefksis.mtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaqg

subfamily_PTPRD_pd Subfamily PTPRD 82-358 3.1e-96 318.3 In-house 8-281 (564) alignment
Range on Protein: 82-358
Range on HMM: 8-281/564.0
IMFAQHVAKMSARNNDGFSDEYNSLPAMeKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDH
  ...||||. | ..  |. ||...    .   ...|..  |  |||. ||..|| .|| |   .|. | ||||||.|   . ...||||||||..||. 
aelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetied

FWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQkPHLHGNVTVTLVGSKQTEHFIQRTLLIGKK--GTELTVTHYQYLAWTDHGVPASTAPLVALLYQ
|| |||| . |||||.| |.| ||.||..|||. . .  .|..||||. ... .... ||. . ||      .|..... .| ||||| |...|..|. .
FWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirk

VKMTSQedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
|. ...     .|||.||||||.|||||||. |.... |.     . .|| ..|..||.||  .|||  |||..|...|  .
vralne...pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheaileal

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 82-157 2.9e-09 30.7 In-house 9-84 (440) alignment
Range on Protein: 82-157
Range on HMM: 9-84/440.0
IMFAQHVAkmSARNNDGFSDEYNSLPAMeKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIA
  ||..|   . |    | ||.. ||.    .   .|    |  |||.|||| ||..|| |   ||   .||||||||.
adfadyvq..nnrrsrafedewsllpsg.lsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 83-358 7.8e-65 213.7 In-house 6-278 (287) alignment
Range on Protein: 83-358
Range on HMM: 6-278/287.0
MFAQHVAKMSARNNDGFSDEYNSLPA-MEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWE
.|.. |||  |..|.||.. .  |    ..   ||..   .| ||||...||..| .|| ||||  .|||||..|   . ....|....|. ||.  ||.
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkge.hpdyinavfidgykekkafiiaesPmfntarnfWk

MVWETKASTIVMMTALVEGGKTKCEHYWPTGQKpHLHGNVTVTLVGSKQTEHFIQRTLLIG---KKGTELTVTHYQYLAWTDHG-VPASTAPLVALlyqV
.... . ..|||.. . |  . .| .|||...   . |. ...|.  ......|.|.| .    |.|....|. ||. .| ..| |.   . |. .    
liddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi...e

KMTSQEDGALTGPIIVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
.|  ..     ..|.||||...||...|.||..   .|...     ||.   . . | |.   |||  ||...  |.|  .
emyktqrkrgntsivvhCsdtvGrsamfcaaat...tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 83-355 4.7e-63 208.1 In-house 14-281 (297) alignment
Range on Protein: 83-355
Range on HMM: 14-281/297.0
MFAQHVAKmsARNNDGFSDEYNSLPAmEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGN---DYINASYIADDQGnrKYIATQGPLPNTIDHF
 ||  | |   |. | ||.|.. ||.  .|.. |||..  | .|.|..|||||| .||.|.    .   ||.|||..   .   ..|.|| | ..|.. |
dfatlvqk..nrhtdvfseeflclpe.aniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadf

WEMVWETKASTIVMMTALVEGGKtKCEHYWPTGQKPHlHGNVTVTLVGSKQTEHFIQRTLLIGKKG--TELTVTHYQYLAWTDHGVPA--STAPLVALLY
| ||.. ..|||||.. . |. | || .||.        |.|.|.|   .. | ||.|.| . |    ..  |  ||.. | |. |.   |.. |. |. 
Wamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklis

QVKMTSQedGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
.|. . .  .   ||..|||.||.|||| ... |  .  ..|   .. .|| |.| |||..|  ||||  || ... ..|
evrkdfs..qnaegPllvhclaGvGrtgvlltidsvvaeakr...ekevdifglvkklrqerpylvqtkeqykfvyvavl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 83-356 2.8e-53 175.9 In-house 6-277 (439) alignment
Range on Protein: 83-356
Range on HMM: 6-277/439.0
MFAQHVAKMSARNNDGFSDEYNSLPAMEKIRAV--TVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTID
 | .|| |.   ... |....... ...   |.  ..| .  .. |||.... ..|. || |    |     |||| ||     .. |||||||  .| |
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

HFWEMVWETKASTIVMMTALVEGGKtkcehYWPTGQKpHLHGNVTVTLVGSKQTEHFIQRTLLIGKK----GTELTVTHYQYLAWTDHGVPASTAPLVAL
.|| .|.| |..||||.| |||  |     |||. ..   .|...|      .  ... | . . ..      | || ...|.|| |. ||| .. .. .
dfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

LYQVkmTSQEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQrstATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
|  .   | .|   .||..||||||.||||| || |. .. ..   . . .|| | |  ||.||. .||.| ||....  .| 
lrai..nsandkeeygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 83-359 6.1e-48 158.1 In-house 8-288 (305) alignment
Range on Protein: 83-359
Range on HMM: 8-288/305.0
MFAQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEM
   . | .   .   |.  |....  .. .  .   ..|.. .|||....   | |||.|.|    .|| | |..     ...| || || .|   || |
qilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwym

VWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHG-----NVTVTLV------GSKQTEHFIQRTLLI--GKKGTELTVTHYQYLAWTDHGVPASTAP
 .. |  .| |.  |.| |  || .|... .|. |.       ..| .         |...  ...| |.  |  .. . |||| .  | | ||||.   
clqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadla

LVALLYQVKmtsqedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDyiDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
.. || . .       .. |||.|||||||||||. .  . ... .      .  |    . |.||||   .||  ||...|...|  ..
ilellekar.......pskgpivvhcsagigrtgsvvmleyildqllagqiie..dtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 83-357 2.5e-47 155.9 In-house 13-282 (290) alignment
Range on Protein: 83-357
Range on HMM: 13-282/290.0
MFAQHVAKMSARNNDGFSDEYNS-L----PAMEKIRAVtVARNArNDDKNRFRNILPYDYNRVQLKGEVGNDYINASYIADdqGNRKYIATQGPLPNTID
 | .  ...  .| |... ||   |    |.    | .   .|. .  |||....   |  || ||     ||. | |.     .  .| |||.| .|. 
afekfasdvvkknvdelakeyleklkpylpvqylerki.fdknt.efkknrykdvvcndktrvilkdGydGdyvhanyvkG..lkamfiltqGalkdtvi

HFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPH-LHGNVTVTLVGSKQTE-HFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVAL
 .| || ..|...|||.  |.| ||.|||.|.|  .      |..||.   ... . . |..|| .   ..| |  . |..  .| |. |. ||  |. .
diwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrt

LYQVKMTSqedgaltGPIIVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
|. .. .|       ||..|||||||||||||.| ..   ..|  .    .|....|  ||. | . ||   ||. | .|.| |
lrilrkas.......GpvvvhcsaGiGrtGtfvaiev...glqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

0051299 (Phosphotyrosine protein) phosphatases II 84-358 3.1e-92 304.4 In-house 10-286 (288) alignment
Range on Protein: 84-358
Range on HMM: 10-286/288.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG---NDYINASYIADDQGNRKYIATQGPLPNTIDHFW
....| |. |... |. .|.. |...   . ...|.   | .|||...|||||..||.|. . |   .||||||||   . .||.||||||||||...||
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW

EMVWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG------KKGTELTVTHYQYLAWTDHGVPASTAPLVALL
 |||| . ..|||.| ||| |..||..|||. ...  .|..||||.  .. .....||| .       ..|...||||..|..| ||||| |. .|...|
rmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl

YQVKMTSQedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
 .|.   .   .  ||..||||||.||||||||.|.|.. ...      .|. ..|..|||||  .|||. ||.......| ..
rlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0040438 (Phosphotyrosine protein) phosphatases II 84-358 1.6e-86 285.8 In-house 5-276 (317) alignment
Range on Protein: 84-358
Range on HMM: 5-276/317.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIrAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG---NDYINASYIADDQGNRKYIATQGPLPNTIDHFW
. ... .. .... ....|.. |. . .    .||.   | ||||...|||||..||.|. . |   .|||||||.   . .||.||||||||||...||
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

EMVWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVK
.|||| . ..|||.| |.| |. ||..|||. ...  .|..||||.. .. .... ||| .   ......||||..|..|.||||| |. .|...| .|.
rmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

MTSQedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTatdYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
   .      ||..||||||.|||||||||..... ...      .|.  .|..|||||   |||. ||..|....| ..
eale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleyl

0043336 (Phosphotyrosine protein) phosphatases II 84-357 1.3e-82 272.6 In-house 7-276 (278) alignment
Range on Protein: 84-357
Range on HMM: 7-276/278.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKiRAVTVARNARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFW
........ . .. ... |. .|. . .    ..|.   | ||||...|||||..||.|.    . ..|||||||.   . .||.||||||||.|...||
llkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

EMVWETKASTIVMMTALVEGGKTKCEHYWPtgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVK
.|||| . .||||.| ||| |..|| .|||  ...  .|..||||.. .. .....||| .   ..| ..|||||.||.| ||||| |...|. .| .|.
rmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavr

MTSQedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTatdYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
   .      ||..||||||.||||||||...|.. ...      .|.  .|..||||| . |||. ||..|....| .
eale...dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 84-358 1.1e-81 269.4 In-house 7-280 (318) alignment
Range on Protein: 84-358
Range on HMM: 7-280/318.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFW
...||... .  .  .| ||. |   |.  . . . .  |  |||. |||.||  ||.|.   ||.| |||||.||   . ...|||.|.|||.||. ||
leshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfW

EMVWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTE--LTVTHYQYLAWTDHGVPASTAPLVALLYQVK
 |||| ....|||.| ..| ||.|...|||  .... .|...|.|  ........ |.. . ....|   .|  |.| .|.|.|||.|.| |..|. ||.
rmvWeqnsavivmltqeeergkakvhryWPs.kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvs

MTSQEDGAltGPIIVHCSAGIGRTGTFIAADMLmnaIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
 . |. ||  |||.||||||.||||.||| |.|   ..|  |   .|. .|| .|||||  .|||  ||.... ..|  .
kaqqksga..gpivvhCsaGvGrtGvfiavdil...lerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal

subfamily_PTPRG_pd Subfamily PTPRG 84-359 5.2e-76 251.1 In-house 6-288 (563) alignment
Range on Protein: 84-359
Range on HMM: 6-288/563.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIR--AVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG---N-DYINASYIADDQGNRKYIATQGPLPNTID
||.|||.. | .. ||| |...|    . .   .. ...  |  |||  ||..||  ||.|..  |   . |||||.||   | ....|||||||..|.|
fakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfd

HFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGK------K--GTELTVTHYQYLAWTDHGVPASTAP
 || |.|| ....|||.| ||| |. ||. |||. ...   |...|||. ....    .||| | .      |   ||..|..|.|  | ||||| ...|
dFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp

LvalLYQVKMTSQEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
    |  ||  |.   | .|||.||||||.|||||.|. | |.. ||.    . ... |.. ..| ||  ||||  |||.|| ..|..| 
v...LifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqe...navnvfgflkhiraqRnflvqteEqYiflhdalleaia

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 84-358 6.9e-74 243.7 In-house 9-283 (305) alignment
Range on Protein: 84-358
Range on HMM: 9-283/305.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKirAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGND---YINASYIADDQGNRKYIATQGPLPNTIDHFW
.|... .... ...|.  .|.||.  |.  .. | ..  |  |||...| ..| .|..|. .  .|   ||||||.   ... |||..||||.||.. ||
laayikearvysdkgleaqykslyeeee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfW

EMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKP-HLHGNVTVTLVGSKQTEHFIQRTLLIGK---KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQ
....|.| |||||.| |||||| ||. |||. ..  . .|...|.|  .|... .|.| | | .   .  . ||..||   | ||||| ... |. |. .
rliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikr

VKMTSQEDGAltGPIIVHCSAGIGRTGTFIAADMLMNaiqRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
|. . ..|     |..||||||.||||.||| |. ..   |  . . .|... . .||..|  .|||| || .|| ..  ||
vqkdqkkdkg..vpllVhCsagvgRtGvfiavdiale...rlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 84-359 3.1e-68 224.7 In-house 7-284 (290) alignment
Range on Protein: 84-359
Range on HMM: 7-284/290.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLK-----GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDH
|...||.  |..|.|| .....| . |.  .|||.    |  .|||.||..|| ||. |.      .  |.||||.|| . . ...|||||||..||. .
fgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvd

FWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHlHGNVTVTLVGSKQTEHFIQRTLLIGKKGT---ELTVTHYQYLAWTDHGVPASTAPLVALLY
||...|. | . |||.|  .| ||.||  |||. .  .  |.....|.  ......|.|.| . .| .   . .||.||  .| ..|  . ..  . ...
FWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvie

QVKMTSQEDGalTGPIIVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
..  |   .|   ..|.||||...||...|.||..   .|..   .  ||.   . ..| |.  .|||  || ....|.|. ..
emyktqrkrg..ntsivvHCSdtvgrsavfcaaat...tinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 84-355 1.8e-64 212.9 In-house 10-285 (325) alignment
Range on Protein: 84-355
Range on HMM: 10-285/325.0
FAQHVAKMSARNNDGFSDEYNSLPAMEKIrAVTVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFW
. .|| |  |...|||. |.. ||. . | | .||    | .||||.|....| .|| |.    .   |||||||. ||..   ..|.| ||..||. .|
lvehvekkkaqdqdgfahefgllpsddgi.akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlW

EMV--WEtkaSTIVMMTALVEGGKTKCEHYWPTG-QKPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLY
 .|  |.   ...|...  ...|| .|  |||    |    | . | |.  ..   ...| | .   |||  ..|  .|. .| | ||.   | |...| 
rlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilq

QVKMTSQEDGA---LTGPIIVHCSAGIGRTGTFIAadmLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
 ||  |.   |    ..||.||||||.||||.||.   |  |...      .|| | | |||..| |.|.|  ||| ..  . 
lvkavservtantkastpilvhcsaGvGrtGvfis...lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 85-359 9.6e-83 272.5 In-house 3-277 (281) alignment
Range on Protein: 85-359
Range on HMM: 3-277/281.0
AQHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWE
 .|....|. .| ||  ||..| |..   . | ...  |  |||..||  ||  ||..   . .  .|||||....  .|...|||||||.|.....||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLI-GKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMT
||||.|.|.|||.|. .|.|| || .||| ...    |.|||. . .......|.|.. .  ..| . .|.. .|.|| ||||||.|. |.    .|. .
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

SQEDGAltGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
....     |...|||||.|||||.|| | |..|.....    .|.  .||.||..|. .|||. || ......|  ..
tekktk..aplvihCsaGvGrtGtyialDrlvkaveael..eeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 85-358 1.5e-77 255.8 In-house 11-283 (319) alignment
Range on Protein: 85-358
Range on HMM: 11-283/319.0
AQHVAKMSARNNDGFSDEYNSLPAMEKIrAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWE
.... .. .  . ..  |.. |   ..   .. | . .| .|||..|||.||  ||.|   .|  | ||||||.|   | ..|.||||.|| |||. || 
kerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWr

MVWETKASTIVMMTALVEGGKTKCEHYWPTGqKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTEL---TVTHYQYLAWTDHGVPASTAPLVALLYQVK
|||| ..|..||.| ||| .| |...|||.  ...  |...|||   ...|..| | | . || .|.   .|.|.||..|.||.|| ..  |..|| ...
mvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrir

MTSQEdgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
 . ..     |||.||||||.|||||||. |. .. ... ..   .|.  || .|| ||  .||.  ||.... ..|  .
ksrek..tqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiyealleav

subfamily_PTPRK_pd Subfamily PTPRK 85-356 3.1e-70 231.5 In-house 10-275 (314) alignment
Range on Protein: 85-356
Range on HMM: 10-275/314.0
AQHVAKMSARNNDGFSDEYNSLPAMekiraVTVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWE
 |..|.. . .. || .||.||.         .|..  | .|||. .||.||  ||.|.   |.  .|||||..|   .  ...|.|||||..|.  || 
lqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWr

MVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPhlHGNVTVTLVGSKQTEHFIQRTLLIGK--KGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQV
.|.. ....|||.| ||| |. || .|||   .   .|.. |.|| ..  . ...|.. . |  .|     .| ..|.|.|.||.|| |   |..|. .|
lvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrv

KMTSQEdgaLTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
|....|     |.|.|||||| |||||||| |.... |.|    . .|.  .| .||.... .|.|  ||.... ..| 
kksqee...eaGrivvhCsaGaGrtGtfiaidivldmiere...gvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_PTPRA_pd Subfamily PTPRA 86-355 2.8e-73 241.7 In-house 21-292 (330) alignment
Range on Protein: 86-355
Range on HMM: 21-292/330.0
QHVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEM
. . . || .|  | .|.|.||| .   .. .| .  | .|||. ||||||..|| |   .|.   ||||||.|   .   |.||.|||. .|.. || |
eeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrm

VWETKASTIVMMTALVEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGT------ELTVTHYQYLAWTDHGVPASTAPLVALLYQ
.|| |..||||.| | |  ..||. |||. .    .||..|..  .. ....  | .|. ...       .  |. . . .| | |||. .  .. || .
iweqksativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkk

VKMTSQEDGAltgPIIVHCSAGIGRTGTFIAADMLMNAIQrstATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
|| . |  .    ||.||||||.|||||||. | ... ..   |   .|. ..| .|| ||. .|||. || ......|
vkklnqqsag...pivvhcsaGvGrtGtfivldavlervk...aerkvdvfefvkrlrlqrpqmvqtdeqyefiykvll

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 86-355 7.3e-69 227.1 In-house 13-276 (315) alignment
Range on Protein: 86-355
Range on HMM: 13-276/315.0
QHVAKMSARNNDGFSDEYNSLPAmEKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEM
 .||.  |  ..|| ..|.|.|   ... . ||..  | .|||. ||..||  ||||   . . . ||.||..|   . .|.|||.|||...... || .
tyvaqkkastkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrl

VWETKASTIVMMTALVEGGKTKCEHYWPTGqkPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQ
|.| . ..|||.| |||| | |.|.|||      ..|..|||..  .. ...  ||| .  .    .|  ..| .| | |||..| ||. |  .||.  .
vfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhht

EDGaltGPIIVHCSAGIGRTGTFIAADMLMNaiqRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
..    |.|.||||||.|||||||. | ...   .  | . ||.   . ..|..|  .||.. || ... ..|
nsv...gaivvhcsaGvGrtGtfitldavld...qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 86-355 1e-50 167.3 In-house 8-233 (392) alignment
Range on Protein: 86-355
Range on HMM: 8-233/392.0
QHVAKM-SARNNDGFSDEYNSLPAMeKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWE
|  | .   | .  |..|.  ||   .|   |||..  |  |||..|||||| .||.|        .||.|||||   . .. |||.||| . ..| ||.
qfpafveknrhsalffeefhdlpgp.diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwr

MVWETKASTIVMMTALVEGGktkcehywptgqkphlhgnvtvtlvgskqtehfiqrtlligkKG-TELTVTHYQYLAWTDHGVPASTAPLVALlyqVKMT
||.. ...||.|.| | ||                                           ||    ||. ...  | |..||  |. |. .   .|  
mvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkf...ikev

SQEDGALTGPIIVHCSAGIGRTGTFIAADMLMNaiqRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
. . |  | |.|.|||||.||||  |. | ..    ..  |  .|.   |...|..|  .|||  || ...  .|
kadfGqythpliihcsagvgrtgvvisidsvva...hakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl

subfamily_PTPN9_pd Subfamily PTPN9 87-355 2.6e-68 225.2 In-house 6-287 (297) alignment
Range on Protein: 87-355
Range on HMM: 6-287/297.0
HVAKMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMV
 || . .... | | ||  . ...    .....   |  |||. ..| ||  ||.|.   ..   |||||...   . .. .|||||||..|.. || ||
lvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmv

WETKASTIVMMTALVEGGKTKCEHYWPT-GQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVK--
|| .. .|||.| .|| |. || .|||.  .. . .|...|. |  ...|.. .|.| |   |.. . .|||.|.|.| |.||| |.| |. .| .|.  
WeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrek

-------MTSQEDGALTG-PIIVHCSAGIGRTGTFIAADMLMNAIQrstATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
       ..... | ..| ||.||||||||||||||. |. .. ..    .. .|.  || .||.||.  .||  || . .  .|
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrle...evgtvdvvetvkllrtqrafsiqtpeqyefcylavl

0036941 (Phosphotyrosine protein) phosphatases II 90-358 3.7e-87 287.7 In-house 6-277 (297) alignment
Range on Protein: 90-358
Range on HMM: 6-277/297.0
KMSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLkGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKAS
.... .. ... |. .|. . ..   .||.. .| .|||...|||||..||.| .. |.|||||||.   . .||.||||||||||...|| |||| . .
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

TIVMMTALVEGGKTKCEHYWPTG-QKPHLHGNVTVTLVGSKQ--TEHFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQE-
.|||.| ||| |. ||..|||.  ...  .|..||||.. ..   .....||| . .  .| ..||||..|. | ||||| |.|.|.... .|.   .. 
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

-DGaltGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
 .|   ||..||||||.||.|||||||.... ..... .  .||  .| ||||||   |||| ||..|....| |.
psg...gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 90-355 3e-48 159.1 In-house 8-290 (301) alignment
Range on Protein: 90-355
Range on HMM: 8-290/301.0
KMSARNNDGFSDEYNSLPAMEKiRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV-----GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVW
.. | ....|...|..|  .|. .  ||  . .|   |||.|| .|| ||. || .       ..||||||| . . ..|.||.|||. .|.  || ..|
hvaakhsnkfeeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

ETKASTIVMMTALVEGGKTKCEHYWPTGQKP-HLHGNVTVTLVGSKQTEHFIQRTLL-----------------IGKKGTELTVTHYQYLAWTDHGVPAS
. | ..|||.| | || |.|||.|||....  .  |..||||| ..    |. | |                  . .. .  .|. .|   | ..||   
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

TAPLVALLYQVKMTSQEDGalTGPIIVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
 .  .  . .| .. |  |   ||..||||....|.|.... ..   ..    |   .|. . .  .| ..   |.|| ||. .. .. 
prtvLqviddvihrqqkig..ggpvvVHCSdtVsrsGvYcsvsi...glEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid

subfamily_Ptp69D_pd Subfamily Ptp69D 91-357 6.1e-71 234.1 In-house 16-285 (307) alignment
Range on Protein: 91-357
Range on HMM: 16-285/307.0
MSARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETK
     . |.  ||..|.| |  .  .|. .  |  |||. .| ..| .||.||    .   ||||||.|   . ..|.|| |.|. .||. || |..| .
rkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

ASTIVMMTALVEGGKTKCEHYWPTGQKPHlHGNVTVTLVGSKQTEHFIQRTLLIGKKG-------TELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMT
  .|||.. | |  . ||..|||  .. . .|.. |.|| .......|.|.| . ||.        .  |. |.|..| |  || ..  |. |..||.  
vtlivmlsnlteknrkkcakYWpiedevq.ygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

SQEDgalTGPIIVHCSAGIGRTGTFIAADMLmnaIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
 . .    .||.|||||| ||.|.|.| |.|   .|.  | | .||  || .||.||. ||| | ||..|.| .|  
ykln...rsPivvhCsaGvgrsgifvaldsl...lqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy

0047943 (Phosphotyrosine protein) phosphatases II 92-358 3e-87 287.8 In-house 7-272 (273) alignment
Range on Protein: 92-358
Range on HMM: 7-272/273.0
SARNNDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLkGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTI
.. .....  |.. |. . ..   .||.  .| ||||...|||||..|| | |. |.|||||||.   . .||.||||||||||...|| |||| ....|
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMMTALVEGGKTKCEHYWPTGQK--PHLHGNVTVTLVGSKQTEHFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQE--DG
||.| ||| |. ||..|||. .   .  .|..||||.. .. .....||| . .   | ..||||..|. | |||||.|...|. .. .|. . ..  ..
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

altGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
   ||..||||||.||||||||.|.|.. ...      .|.  .|..||.||   |||. ||..|....| ..
...gpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 92-354 1e-67 223.2 In-house 14-273 (315) alignment
Range on Protein: 92-354
Range on HMM: 14-273/315.0
SARNNDGFSDEYNSLPAMEkIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKA
  |.   ||.|.. ||  . |   .|||.  |  |||..||||.| .||.|     .  .||||||||   . .. |||.||||. ..| ||.||...|.
knrhtalfseefhdlpdPd.iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekv

STIVMMTALVEGGKTKCEHYWPT-GQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTsqeDGAL
.||||.| . || | ||  |||    .    |.. |.|.  ...   ..| | . |  .  ||| .|.  | |.||.  |. |. |. .||     .|  
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad...ngkk

TGPIIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIM
. ...||||||.|||| .|..|  .. |.|   |. .|.  .| .||..|  ||||  .| ... ..
efsllvhcsaGvGrtGvvisidevvaqikr...trsvdvfnfvknlrakrpylvqteeeyafiydav

subfamily_PTPN6_pd Subfamily PTPN6 93-359 9.1e-82 269.5 In-house 22-298 (306) alignment
Range on Protein: 93-359
Range on HMM: 22-298/306.0
ARNNDGFSDEYNSLPAME--KIRAVTVARNARNDDKNRFRNILPYDYNRVQL--KGEVGNDYINASYIADD--QGNRKYIATQGPLPNTIDHFWEMVWET
  .. ||..|...|  .|  |    . .. ..|  |||..||||.| .|| |  .. .|.|||||.|| ..  . ...|||||| |..|.  ||.|||. 
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqe

KASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG---KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQE
..  |||.|  || || || .|||. .. . .|...|| | .|.....| |.|..    ||..| .| .|.. .| |||||...  ....| .|.. ..|
nsrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqee

DG-ALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
   | .|||.||||||||||||||  |.|.. |...     |||  .| ..||||  ||||  || ......   ||
leeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 93-355 3.6e-68 224.9 In-house 12-273 (515) alignment
Range on Protein: 93-355
Range on HMM: 12-273/515.0
A--RNNDGFSDEYNSLPAMeKIRAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETK
.  |.   ||.|.. ||   .|   |||..  |  |||..|||||| .||.|   . .  .||.|||||   . .. |||.|||.. ..| || .|.. .
nknrhttlfseefhdlpgp.niypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqen

ASTIVMMTALVEGGKTKCEHYWPT-GQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKmtsQEDGA
 .||.|.| | || | || .|||    .    |.. | ||  .     |.|.| . |     ||| ...  | |.|||  |  |. |. .||    . | 
vttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevk...adhgq

LTGPIIVHCSAGIGRTGTFIAADmlmNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
.| |.|.|||||.|||| .|..|   . . .   |. .|.  .| ..|..|  ||||  || ... ..|
ythpliihcsaGvGrtGvvisid...svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 93-355 1.5e-61 202.7 In-house 5-263 (283) alignment
Range on Protein: 93-355
Range on HMM: 5-263/283.0
ARNNDGFSDEYNSLPAMEKIRAVTVARnaRNDDKNRFRNILPYDYNRVQLKGEVGnDYINASYIA---DDQGNRKYIATQGPLPNTIDHFWEMVWETKAS
. ||. | . .. |   ..   ...|.  .|. |||...|.|.| .||.|| |   |||||..|    ... ..|||..|.|| .|.  || ||.. |..
vnnnklfrevlkrlsvpdldadiasad..enkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

TIVMMTALVEGGKTKCEHYWPTGQKpHLHGNVTVTLVGSKQTEHFIQRTLLIGKK---GTELTVTHYQYLAWTDHGVPAstaPLVALLYQVKMTSQEDGA
.|||.| | |. . ||  |||       .|. ||||      . ||.. ||. ..    ..| ..|||.  |.. |  |   .. .|.   |. |.    
aivmltklqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqa...iinslvkfnkvislqtes

LTGPIIVHCSAGIGRTGTFIAAdmlMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
  |||.||||.|||||..||||   . ...   .   .|.  .|  .||||  .|||| ||  .| ..|
kkgPivvhCstgiGrtavfiaa...sasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl

subfamily_PTPRN_pd Subfamily PTPRN 94-349 2.3e-55 182.4 In-house 26-283 (297) alignment
Range on Protein: 94-349
Range on HMM: 26-283/297.0
RNNDGFSDEYNSLPAMEKIRAV-TVARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIADD-QGNRKYIATQGPLPNTIDHFWEMVWETKA
.|.| .. |...| | |   .. .||.. .| .||| ...|||| .||.|| |     .|||||| | |.   .  ||||||||..|. .||.||||  .
knkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

STIVMMTALVEGGKTKCEHYWPTGQkPHLHGNVTVTLVGSK-QTEHFIQRTLLIGKKGTE--LTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQedG
  ||..| | | | ..|..|||     ....   | ||  .  .. .. |.. .    |.   ||| . .|.|...|||||. .|. .  .|  . .  |
vvivnltrleeegvkqckrywpdeG.sevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..G

aLTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTatDYIDIAGTVAKLREQRTSLVQTLYQYIY
  . ||.||||.| ||||..|. |...| ...      |||| |. .||.||. ||.|  |. .
.rscpivvhcsdGaGrtGvyilidlvlnrllkGv..keidiaatlehlrdqrpglvktkdqfef

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 96-355 8.2e-43 141.5 In-house 18-268 (288) alignment
Range on Protein: 96-355
Range on HMM: 18-268/288.0
NDGFSDEYNSLPAMEKIRAVTVarNARNDDKNRFRNILPYDYNRVQLKgEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMT
 .|   ||.  |    |.....     |  ..|..|.   |. ||.|. .  . ||.|  ..  . .|. | .| ||  ||. .|.|. |.    |||..
veglkkeyrdspneasidiids..fianptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlc

ALVEGGKTKCEHYWPT--GQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG-KKGTELT-VTHYQYLAWTDHGVPASTAPLVALLYQVkmtsqedGALTGPI
 |.| || | ..|.|.  |.| ..  . ||. .  .. .. .. .||   |.| |   | .  .| | |.||| .  . . ||  .        .|. ||
ellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqkPi

IVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
.||.|||.|||||.|   .   |..    .|.. |   .|||||.|   .||  ||.|.||..|
vvhssaGvGrtgtlilili...aleslrlddflgirsllaklreerfkaiqtemqylyvhrcvl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 96-356 1e-40 134.2 In-house 10-267 (281) alignment
Range on Protein: 96-356
Range on HMM: 10-267/281.0
NDGFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV----GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTI
 | | .|.  ||       .||  .  |. |||. ||   |  ||||| ..      ||| | ||     .| || ||||  .|   || |.|. ....|
lddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMMTALVEGGKTKCEHYWPTGQKPHLH-GNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSqedgaltGP
||.  ..|  . ||  |.|   .  |.  ...|.   |   . ..   | .  .|    .||. .  | |  || |.  .. .| ...  |        |
vmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars.......tp

IIVHCSAGIGRTGTFIAADMLMNAIQRStaTDYIDIAGTVAKLRE-QRTSLVQTLYQYIYLHRIMLS
 ..|||||.||.||..| .. ...|.        ||   |..||   |.. |||| ||. . ...| 
pvihcsagvgrsgtlmaveialqsihsh..ftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 97-357 1.4e-32 107.5 In-house 27-289 (310) alignment
Range on Protein: 97-357
Range on HMM: 27-289/310.0
DGFSDEYNSLPAMEKiRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV--GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMM
.|.  .|  | | .   ..|     ..  |||. ...  |  ||.|| .    .||| | |.  .     .| .||||  ||  || |... .| .|...
eglvkqyrkldakqd.ssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilll

TALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEH--------FIQRTLLIGKKG---TELTVTHYQYLAWTDHGVPASTAPLVA--LLYQVKmts
   .| |. ||  |||.      .| . || ..    |         |.   . . ..     || |.  ..  | | |||      |   || ||.   
ckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr...

qedgalTGPIIVHCSAGIGRTGTFIAADMlmnAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
       || .||||||..|... .| ..   .|...   ...|.   ...|. .|.  .||  ||....|... .
......hgpcvvhcsagkdrlyvvvalkl...kidkldrglkvdaeevktellksraiciqtelqyliidrvriif

0045098 (Phosphotyrosine protein) phosphatases II 98-358 4.4e-76 251.2 In-house 8-272 (278) alignment
Range on Protein: 98-358
Range on HMM: 8-272/278.0
GFSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQlkgevgnDYINASYIADDqgNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTAL
 .. |.  |...  .  .|.|    | ||||...|||||..||        ||||||||     ..|.||||||||.|...||.|.|| . ..|||.| |
dlllefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltel

VEGGKTKCEHYWPTgQKPHLHGNVTVTLVGSKQTEHFIQRTLLIG------KKGTELTVTHYQYLAWTDHGVPAST--APLVALLYQVKMTSQE------
||.|. ||..|||  ...  .|..||||.  ....... ||||.       . .....|||..|| | ||||| ..  ...  || ...   ..      
velgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------DGaltGPIIVHCSAGIGRTGTFIAADMLMNAIqrstaTDYIDIAGTVAKLREQRTS-LVQTLYQYIYLHRIMLSLI
       .|   ||..||||||.|||||..||....  .      . .|.  .|..||.||    ||.| ||..|.. .| |.
sslllldsg...gpvlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 98-357 1.1e-47 157.6 In-house 17-276 (307) alignment
Range on Protein: 98-357
Range on HMM: 17-276/307.0
GFSDEYNSLpAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGE-VGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTA
 . ||.. | |  .  .|||     | ||||....   | .|. .| . .  ||| | |.      .|.|..|||| ||. .|| |. . |  ...|.  
alvdefrvl.akktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

LVEGGKTKCEHYWPT--GQKPHLH---GNVTVTLVGSKQ---TEHFIQRTLL-IGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTsqedgal
..| .| ||| |||   |||         ..|. .|.|.    |..|. | | .   .   |..|.|.  | |.|||      . ||  |.         
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd.......

TGPIIVHCSAGIGRTGTFIAADMLMNAIQRStaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
| |..||||||.||.|| .|  .... . .    .  |.   | .||.||   .|| .||.||||..|. 
tnpvvvhcsaGvGrsGtivaislvqdkmiaG..inckdmkklveelrsqrhyaiqteaqylylhrvlley

0046845 (Phosphotyrosine protein) phosphatases II 99-358 1.6e-88 292.1 In-house 2-274 (284) alignment
Range on Protein: 99-358
Range on HMM: 2-274/284.0
FSDEYNSLPAMEKIR--AVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG----NDYINASYIADD-----QGNRKYIATQGPLPNTIDHFWEMVWETK
. .|.  |. .   .   ..||.   | .|||...|||||..|| || . |    .|||||||.          ..|.||||||||||...|| |||| .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

ASTIVMMTALVEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGK---KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEd
...|||.| ||| |..||..|||. ...  .|..||||.  .. .....||| . .   .| ..||||..|..| |||||.|...|...| .|.   .. 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.

GALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
    |||.||||||.||||||||.|.|.. ...   .  .|. ..|..|||||   |||| ||.......| ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

DSPc_SM00195 99-358 1.9e-85 281.7 In-house 2-262 (263) alignment
Range on Protein: 99-358
Range on HMM: 2-262/263.0
FSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMT
.. |...| .... . .| |.  .| .|||..|||||| .||.|| |    |.|||||.||  .. ..||||||||||.|...||.||||.| ..|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

ALVEGGKTKCEHYWPTG-QKPHLHGNVTVTLVGSKQTE-HFIQRTLLIGKKG--TELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgalTGPI
  .| ||.||..|||   ...  .|...|.||  .... ..|.||| . |.|  .. .||.||| .|.||||| || ....|| .|| ....    .|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

IVHCSAGIGRTGTFIAADMLMNAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
.||||||.||||||...|.... ... .    .||  .| .||.|| ..|||| ||.......| .|
vVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 99-358 1.9e-85 281.7 In-house 2-262 (263) alignment
Range on Protein: 99-358
Range on HMM: 2-262/263.0
FSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMT
.. |...| .... . .| |.  .| .|||..|||||| .||.|| |    |.|||||.||  .. ..||||||||||.|...||.||||.| ..|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

ALVEGGKTKCEHYWPTG-QKPHLHGNVTVTLVGSKQTE-HFIQRTLLIGKKG--TELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgalTGPI
  .| ||.||..|||   ...  .|...|.||  .... ..|.||| . |.|  .. .||.||| .|.||||| || ....|| .|| ....    .|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

IVHCSAGIGRTGTFIAADMLMNAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
.||||||.||||||...|.... ... .    .||  .| .||.|| ..|||| ||.......| .|
vVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPN13_pd Subfamily PTPN13 99-358 4e-76 250.9 In-house 13-269 (273) alignment
Range on Protein: 99-358
Range on HMM: 13-269/273.0
FSDEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGndYINASYIADDQ--GNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTA
 ..|.. |  .  .  ..|.....| ||||.||.||||  ||.|..| |  |||||.|       . .|||.|||||.|.. || |||| ||. |.|.| 
PaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

LVEGGKTKCEHYWPTGQ--KPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQeDgalTGPII
 .|.|| ||. |||  .  |  ... ..|.|.. .. . | .|.| . .. .     |.| .. .| |||||.|.|.|. .. .|.   . |   .|||.
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.d...agPiv

VHCSAGIGRTGTFIAADMLMNAIQRSTatdYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
|||||||||.||.|. |.... |.| .    .|.  .| |||||| ..|||  |||. ....| ..
vhcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 99-355 1.5e-69 229.1 In-house 7-265 (274) alignment
Range on Protein: 99-355
Range on HMM: 7-265/274.0
FSDEYNSLPAMEKIRAVTVARnarNDDKNRFRNILPYDYNRVQLKGEVG----NDYINASYIADDQG-NRKYIATQGPLPNTIDHFWEMVWETKASTIVM
. .|. .||.  . . ..|..   .  |||...||| .  || |. | .     .|||| ||   .. .. |.|||||||||.. ||.|....... |||
lekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

MTALVEGGKTKCEHYWPTGQKP---HLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDGALTGP
.| | |  ..||..|.|. ..    . .|.| .. .. ......  |.|.. .   | .|.|| | .| || .| .. .|. |. .|. . .|. | ..|
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklap

IIVHCSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
..||||||||||| |||... .. ...   .  .|. ..|..|| .|  .|||  || ..||.. 
vvvhCsaGiGrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_CG42327_pd Subfamily CG42327 100-280 7.2e-33 108.6 In-house 8-193 (319) alignment
Range on Protein: 100-280
Range on HMM: 8-193/319.0
SDEYNSLPameKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIA-DDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMT
 .|.. ||   .. | . .  .  .||.|. |..|    || |.       . |..|||.   |. .  |||.| .| ..   || .||| .. .|| .|
aeefrdlP...qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

ALVEGGKTKCEHYWPT---GQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTEL--TVTHYQYlAWTDHGVPASTAPLVALLYQVKMT
 | | |  .| .|.||   ..  .|.|.. ||| | .  ....  |||. .   |.   .||| |  | . .|||. |.|.|.| .|. .
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 100-358 3.2e-21 70.0 In-house 29-285 (302) alignment
Range on Protein: 100-358
Range on HMM: 29-285/302.0
SDEYNSLPAMeKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVgNDYINASYIADDQGNRKYIATQGPLPNTI---DHFWEMVWETKASTIVMMTA
 .|.... .| |. .       .| .||.  ..  .| |.|.|..|  ..|.||| .   . .|. | .| |  ..    ..|| ||.. |  ..|..  
kkefkkidtm.kvdlekCkafkknlkknqsedvpildsnlvkleaep.dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvg

LVEGGKtKCEHYWPTGQ-KPHLHGNVTV--TLVGSKQTEHfIQRTLLIGKKGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQVkMTSQEDGalTGPI
  |  |   ....|. . . . .|.. |    | ... |.  . .. .  .|    . .. |    | .. || . | |..   .|  ......  . ..
eeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkika..dent

IVHCSAGIGRTGTFIAADMLMNAIQRSTATdyiDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
..    |.|| |.|... . .. .|.. .     |. .|...|.||.. |..| ||. |....| .|
vivSknGaGRagafltlavaveklqkgkep...nikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 101-356 1.9e-67 222.9 In-house 38-289 (319) alignment
Range on Protein: 101-356
Range on HMM: 38-289/319.0
DEYNSLPAMEKI-RAVTVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTa
 |.. .. .       | |   .| ||||. |||..| |.|.|.   || . ||||||...  | . ||||.||||.||.. || |.|| ..||||..| 
vefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.

lveggKTKCEHYWPTG-QKPHLHGNVTVTLVgsKQTEHFIQRTLLIGKKGTE---LTVTHYQYLAWTDHGVPASTAPLVALLYQVK-MTSQEDGalTGPI
     | ||  |||   .. . ...| |..|  ..|. .. | . . ..| |     .| . .| | |.||| ....|. |. .|. .||.|..    .|
.....kdkcsqywplkivikeerfkvkvdsv..eetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh..rani

IVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
.||||||.||||..|. |.|.. ...    . .|.  .|  ||.||  ||| | || ...  .| 
vvhcsaGvGrtGvyivldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPN14_pd Subfamily PTPN14 101-358 8.7e-62 203.8 In-house 27-296 (300) alignment
Range on Protein: 101-358
Range on HMM: 27-296/300.0
DEYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKG--EVGNDYINASYIADDQG--NRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTA
 ||. .| ...   ...|..  | .||||...|||. |||.|.   |  ..||||| |    |  .|.||..||||..|.  ||.||||.. . |||.|.
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlte

LVEGGKTKCEHYWPTGQKP---HLHGNVTVTLVGSKQTEHFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDG------
  |.||.|. .|.|  ..      .|.  ||   |.... .| ..| .     . | || | ||  |.|||||    . .  | .|.   ..        
eeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk

ALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
    |..||||||.||||  | .|.|.....     . |||  ..|.||||| .||||| || .......  .
eskPPvlvhCsaGvGrtGvlilsdlliatlehn...eeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 101-354 7.9e-43 141.4 In-house 10-255 (267) alignment
Range on Protein: 101-354
Range on HMM: 10-255/267.0
DEYNSLPAMEKIRAV-TVARNARNDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVE
 |.. .  . ....  .      |...||. . |||| .|| |. .  ..||||||.   . ....|.||.|| ||| .|.... . | ..||..|   .
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft

GgktKCEHYWPTG-QKPHLHGNVTVTLVGSKQTEHFIQRTLL-IGKKGTELTVTHYQYLAWTdhgVPASTAPLVALLYQVKMTSQEDGAlTGPIIVHCSA
.   .   .||    . . . ..||     |. . .   ||    |. .   || | |  |    . .   | .  |. .    | . .   |..|.||.
d...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwn...intnnkpylkplfgilaknqleng.nrPlvvacsd

GIGRTGTFIAADMLmnaIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIM
|.||.|||. .|     ..|    .  ||   . |.|.|| .||.|. .|||.|...
GvGrsGtflvidsq...leraktegvsdifdflrkirsqriglvdtkeryiyihell

subfamily_PTPN3_pd Subfamily PTPN3 102-355 9.3e-71 233.0 In-house 20-272 (280) alignment
Range on Protein: 102-355
Range on HMM: 20-272/280.0
EYNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVGnDYINASYIADDQGN----RKYIATQGPLPNTIDHFWEMVWETKASTIVMMTAL
... |   .. .|...|| ..| .|||.|.|||||  ||.|| .   |||||.|.  .        .||||||||..|  .||.|||| |.|.|||.| |
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl

VEGGKTKCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKG--TELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQedgALTGPIIVHC
|| |..|| .|||. ..   .|. .|..  ...|. .. | |.. .|    | .... |||||.||||| ..| .. .. .|. . .   . . |..|||
verGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs...gkeePvvvhC

SAGIGRTGTFIAADMLMNAIQRSTATDYIDIagtVAKLREQRTSLVQTLYQYIYLHRIML
|||||||| .|. .. .  |... .   .||   | ..|.||..||||  || ..   .|
saGigrtGvlilletalalieaaepvypldi...vrtmrdqramlvqtasqykfvCeail

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 103-357 5.2e-50 165.0 In-house 13-294 (297) alignment
Range on Protein: 103-357
Range on HMM: 13-294/297.0
YNSLPAMEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKGE-VGNDYINASYIA--DDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVE
...|    .  . ..|.      |||.|.|| .| .||.|..   ..||||| |..  |.. . ||| .|||| .|.| ||..|.|    .|||.. | |
kdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqe

GGKTKCEHYWPTGQKPHL-HGNVTVTLVGSKQTEhF---IQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVAL--------------LYQVK---
.|. ||  |||  ..  |  |.| |  . |   | |   |   | .  .  .  |.| |.|.| |||||.    || .              |  |.   
dGrdkcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemft

-------MTSQEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATdyiDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
        . . .     ...||||||.||.|  . .|.... ...       |.|  . .|||||. ||||| |. .|. ..|  
amvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkrip...dvaailsilreqrarlvqtleqfellydavlkk

subfamily_PTPN12_pd Subfamily PTPN12 109-359 3.6e-77 254.1 In-house 26-278 (290) alignment
Range on Protein: 109-359
Range on HMM: 26-278/290.0
MEKIRAVTVARNARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKC
.||.   ..... .|  |||...|||||..||.|.    | |.|||||..|   .|. .|||.|||||.|.| || |.||.. . .||.  .|| ||.||
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

EHYWPTGQKPHL-HGNVTVTLVGSKQTE-HFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQedgALTGPIIVHCSAGIGRTG
|.|||  .. .| .|...|||   |...  |. ||| . ..... .|. ..| || |||||.|. .|..|. .|. . .   .   |..||||||.||||
erYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtG

TFIAADMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLIE
| || |.  ..... . .. .|.   |..||.||..||||  || .... ...|..
tiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 110-214 6.3e-15 49.3 In-house 35-158 (349) alignment
Range on Protein: 110-214
Range on HMM: 35-158/349.0
EKIRAVTVARNARNDDKNRFRNILPYDYNRVQLK-----------------GEVGNDYINASYIADDQ--GNRKYIATQGPLPNTIDHFWEMVWETKAST
 .|  | ..   .   |||...||||.. ||.||                 . . .||||| |.   .   ..|||||| ||| |.| |....   .   
seiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvkl

IVMMTALVEGGKTKCEHYWPTGQK
.. ..   | .  ||. ||  .. 
vlsLnddkelslekcdiywqelsy

subfamily_eak_pd Subfamily eak 111-267 3.5e-20 66.7 In-house 40-198 (332) alignment
Range on Protein: 111-267
Range on HMM: 40-198/332.0
KIRAVTVARNARNDDKNrFRNILPYDYNRVQLKGEVGN--DYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHY
.........   . ..|   .|.|||.. |.|     |   ||||| .   .  |||| |  .  . .  ||.|| | |. .||..   || .  | . |
rllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdky

WPTGQ-KPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPAST
.|    .   .| . |.     . . .  | | . |      | ||..  ||.  .|   
fpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkye

subfamily_PTPN23_pd Subfamily PTPN23 112-356 2.1e-65 215.4 In-house 32-278 (288) alignment
Range on Protein: 112-356
Range on HMM: 32-278/288.0
IRAVTVARNARNDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIADD-QGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWP
 |  ..|   .. .|||.|.||||| |||.|.|.  .||||||.. |   |  ..||||.||..|.  || ||.| |.|.|||..   | ||.|...|||
arkrsiaiaklyseknrsrdilPyDhnRvklrgs.kDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

TG-QKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTE--LTVTHYQYLAWTDHGVPASTAPLVALLYQVKM-TSQEDGALTGPIIVHCSAGIGRTGTFI
.   ... .|...|||   ..||....|.| .  ....   .|.| |. .|...|||||   |...| .|.   ...   .  |..||||||.||||.| 
edkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa

AADMLMNAIqrSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
     ....  ..    .||   | .|||||   ||.  |.  .  ..| 
lvyaavrel..ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 112-218 1.4e-26 88.1 In-house 36-159 (350) alignment
Range on Protein: 112-218
Range on HMM: 36-159/350.0
IRAVTVARNARNDDKNRFRNILPYDYNRVQLK-----------GEVGNDYINASYIADD------QGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMM
.  | ..   .   |||..|||||. .||.||              .||||||.|.         . . ||||||.|||.|.| |.... . |   |...
snDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

TALVEGGKTKCEHYWPTGQKPHLH
|..|| .  ||..||. |.    .
tsdvelnlekcyrYWqegsyddit

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 113-358 1.7e-69 228.8 In-house 10-264 (270) alignment
Range on Protein: 113-358
Range on HMM: 10-264/270.0
RAVTVARNARNDDKNRFRNILPYDYNRVQLKGEVG---NDYINASYIA-DDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHY
   ..   ||.   ||...|||    ||.|. .       |||| |..  |. ..||||..||||.|. .|| |.||.|...|||.| |.| |..||| |
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPTGQKP---HLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTA------PLVALLYQVKMTSQEDGALTgPIIVHCSAGI
||. .|      .|...|. . ....| .|.. | . .||.|  ..|..| .| ||||| ..        |...| .|. ...|    . |..||||||.
WpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGv

GRTGTFIAADMLMNAIQRSTATDYIDIagtVAKLREQRTSLVQTLYQYIYLHRIMLSLI
|||||.|| |. ........  | . |   ...||..|. |||.  || .|.. ..  .
gRtGtlialDiavrlLeetkkvdvlai...ieelRkdRmalvqhpeqyeflykavveya

subfamily_CG7180_pd Subfamily CG7180 113-356 1.9e-49 162.9 In-house 32-288 (296) alignment
Range on Protein: 113-356
Range on HMM: 32-288/296.0
RAVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKtKCEHYW
     . .. | .|||  ...||||||| |   .||  .|||||.|.     ...|| |..|  .|.| ||..|.. ..|..|..|   .  | ..  ||
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PTGQkPHLHGNVTVTLVGSKQTEHFIQRTLLIGKK------------GTELTVTHYQYLAWTD-HGVPASTAPLVALLYQVKMTSQE--DGALTGPIIVH
|  .  . .|.. | .| .||  .. .||. . ||              . .|...|.  |   . || ||. |. |. .|..  ..  .   .||..|.
pnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGIGRTGTFIAADMLMNAIQRstaTDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
.| | .|.| ..|.|. .. ...   .. .|. . | .||..|  ||..  .| |.  ..| 
ssdGasRsGvylaidanlelvek...eeevdvFeavktlrrsRpqLvenveeYkyiYdvlle

subfamily_egg_pd Subfamily egg 114-356 2.3e-31 103.6 In-house 31-268 (307) alignment
Range on Protein: 114-356
Range on HMM: 31-268/307.0
AVTVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGgkTKCEHYWP
..| | .. | .| | . .   |. ||.|   .|   .|.| | ..  .    ..| .| || || | || ||.. .   |||.|. .|    .||.|||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

TGQKPHL-H--GNVTVTLVGSKQTEH--F-IQRTLLIGKKGTELTVTHYQYlAWTDHGvpASTAPLVaLLYQVKMTSQedgaltgPIIVHCSAGIGRTGT
  ..  |    |.. .. .. ...    | . .  |.| .  |. . |.|.  .   .      ||  .| ...  |.       |..|..  |. ...|
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss..dvysplr.vlrklrnlsk.......pvvvqdilGvskaat

FIAADMLMNAIQRSTATDYIdIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
..|... .  . |   | .. .  .|  || .|   |..  .|....|..| 
lvaieiallsllrGpitksl.vlravvflrlrrrlsvesvllylfvyrlvlf

subfamily_PTPN1_pd Subfamily PTPN1 115-348 1e-66 219.6 In-house 24-261 (290) alignment
Range on Protein: 115-348
Range on HMM: 24-261/290.0
VTVARNARNDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQK
...|.. .| ..||.|.. |||. |..|. .  ||||||| .  .. .|.|| ||||||||.||||.|||| |. ..||.  .|| ...|| .|||.|..
treaklpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-PHLH---GNVTVTLVGSKQTEHFIQRTLLIGKKGTEL--TVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEdGALTGPIIVHCSAGIGRTGTFIAA
   |     ...|.|.  ....... |.| . .. |.   ...|. |..|.| ||| | | .. .|..|. .        || ..||||||||.|||. .
ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsl.ssdvGpavihcsaGiGrsGtfclv

DMLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYI
| ..  |...  .. .||  .. .||..|. |.||  |  
dtclvliekkddlssvdikkvllelrkyrlGliqtadqlr

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 115-353 7.1e-18 59.2 In-house 39-274 (303) alignment
Range on Protein: 115-353
Range on HMM: 39-274/303.0
VTVARNARNDDKNRFRNILPYDYNRVQLKGevgNDYINASYIADDqGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQK
|.  .  .| ||||| ...  |. .|.|       || |||.  |  ..| | || ||. |   ||.|. | |   .... .  |  |   .  .|  | 
vsknqfvknmdknrfvdvicldhskvklsd...ssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

PHLHGNVTVTLVGSKQTEHFIQRTL--LIGKKGTELTVTH-YQYLAWTDHGVPASTA-PLVALLYQVKMTSQEDGALTGPIiVHCSAGIGRTGTFIAADM
     . .. .   |. |     .|  |   .|.  .  | ..| ||    .|. ..  .|  ..|..   .     | ..     .| ||.|||   . 
flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptv.ymslsgcgragtfalfet

LMNAIQRSTATdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRI
   ...   |.  .|.   . ..|. |   || | |. ... .
ahlslhseqas..ldlvkclenvrngrlhavqnlsqfsvvytl

0040439 (Phosphotyrosine protein) phosphatases II 116-358 8.5e-76 250.1 In-house 4-246 (249) alignment
Range on Protein: 116-358
Range on HMM: 4-246/249.0
TVARNARNDDKNRFRNILPYDYNRVQL---KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTg
.||.   | ||||...|||||..||.|   .|  ..||||||||   . .|..||||||||.|...||.|.|| . ..|||.| ||| |. ||..|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

QKPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgALTGPIIVHCSAGIGRTGTFIAADM
...  .|..||||.  .. .....||| .   ..|...||.|.||. | ||||| |...|.... .|.   .|.    ||..||||||.|||||||||..
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaayl

LMNAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
... ...      .|.  .|..||.||   ||.. ||..|....| |.
mleqlekelg...vdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 116-356 5.1e-67 220.7 In-house 2-240 (250) alignment
Range on Protein: 116-356
Range on HMM: 2-240/250.0
TVARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTkCEHYWPTg
.||.. .| .|||. .|...|  || |. |      ||||||..   .... .|||||||..|| .|| ||.| |..||||.| |.| .|| ...|||. 
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.

QKPHLHGNVTVTLVGSKQTEHFIQRTLLIGKKGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDGalTGPIIVHCSAGIGRTGTFIAADM
.|.. .|.|||.|  ...   ...|.| . |.    | .| ......| | |||. .   ..|| .|. . |. |  ..|.||.||||.||.|.||| | 
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqag..naPvivqCsaGvgrsGafiaida

LMNAIQRSTatdYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
... ....     .|.   . .||..|   |..| ||.....|.| 
vlerlkkek...vvdvfkvikvlrkdrphavesleqyvfvyeiilk

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 116-356 1.3e-66 220.0 In-house 18-253 (284) alignment
Range on Protein: 116-356
Range on HMM: 18-253/284.0
TVARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTalveggKTKCEHYWPTG
| |   .| ||||. .||..| |.|.|.   || . ||||||.|.  | . |||||||||.||.. || |.|| ..||||..|      | ||  |||  
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk

Q-KPHLHGNVTVTLVgsKQTEHFIQRTLLIGKKGTE---LTVTHYQYLAWTDHGVPASTAPLVALLYQVK-MTSQEDGalTGPIIVHCSAGIGRTGTFIA
  . . ...| |..|  ...| .. | . . ..| |    ... . .| | |.||| ....|..|. .|. .||.|..    .|.||||||.||||..|.
ivikeerfkvkvdsv..eeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenh..ranivvhcsagvgrtgvyiv

ADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
 |.|.. ...    . .|.  .| .||.||..||| | || ...  .| 
ldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysalle

0049772 (Phosphotyrosine protein) phosphatases II 116-358 1e-40 135.8 In-house 39-280 (314) alignment
Range on Protein: 116-358
Range on HMM: 39-280/314.0
TVARNARNDDKNRFRNILPYDyNRVQLKG--EVGNDYINASYIaddQGNRKYIATQGPLPNTIDHF----------WEMV--WETKASTIVM--------
.||.  .| ||||. .|||.| |||.|.|    | |||||||.    | .|.|||||||..|.. |          |.||  .. .  .|||        
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyv...dgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------MTALVEGGktkceHYWPTGQKPHLHgnvtvtlvgskqteH-------FiqrtlligkkgtELTVTHYQYLAWTDHGVPaSTAPLVAL
              . | ..|      ...    ..|.                      |            | .. .| .. ..|...| ... . ..
elsrLdaAlgKtpllildgng.....neptaadlellk..............eelydpelf............erlgikylripvpDgsap.lledfdef

LYQVKMTsqedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQrstatdyIDIAGTVAKLREQRT-----SLVQTLYQYIYLHRIMLSLI
|  ..          ||..|||.||.||||||..|..|| . .       .... ... .|..|.     .....| ||.. ....| ..
lefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkllg.......vsleealedvrlkRpinpnpgfieqleqyefilealleyl

0042113 (Phosphotyrosine protein) phosphatases II 117-358 4.2e-73 241.1 In-house 3-243 (245) alignment
Range on Protein: 117-358
Range on HMM: 3-243/245.0
VARNARNDDKNRFRNILPYDYNRVQLKGEV---GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTgQ
||.   | ||||...|||||..||.|. .    ..|||||||.  .. ..|.||||||||.|...||.|.|| . .||||.| ..| |. ||..|||. .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

KPHLHGNVTVTLVGSKQTEHFIQRTLLIG--KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEdgALTGPIIVHCSAGIGRTGTFIAADML
 .  .|..||||.. .. .....||| .   ... ...|.||.|| | ||||| ... |. .|  |.   .|     ||..||||||.|||||||||...
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylm

MNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
.. ...      ...  .|..||.||   |||. ||..|....| |.
leqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 117-352 7.2e-60 197.2 In-house 32-271 (287) alignment
Range on Protein: 117-352
Range on HMM: 32-271/287.0
VARNARNDDKNRFRNILPYDYNRVQL--KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQK
 | .  .  |||. ..||.| .|| |  .|| | ||||| |.|  . . ..||.|||.. |.  || .|.||.......||  || .. || .|||  ..
aaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerev

PHLHGNVTVTLVGSKQT-EHFIQRTL-LIGKKGTE-LTVTHYQYLAWTDHGVPASTAPLVALLYQV--KMTSQEDGALTGPIIVHCSAGIGRTGTFIAAD
| . |  .|.|.  ..   ..  |.| ||  .. |   |  ...|.| |.... ..  |. .  .|  ..  . |.. .||..||...||||.|...|  
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

MLMnaiQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHR
.|.   .|   .  .|.| .|..|||.|..|||.  |. .|  
vlv...srledlGrvdvaavvirlreyraalvqavvqlrllye

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 117-357 1e-43 144.2 In-house 44-288 (305) alignment
Range on Protein: 117-357
Range on HMM: 44-288/305.0
VARN-----ARNDDKNRFRNILPYDYNRVQLKGEVGNDYINASYIADD-QGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWP
|| |       .  |||....   | . |.|.     ||| | |.      ....|..|||| .|||.|| || . |   |||.   || || || .|||
vafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywp

T--GQKPHLHGNVTVT-LVGSKQTE--HFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKmtsqedGAlTGPIIVHCSAGIGRTG
.  |.| .|.. . |  . |||  |    || |||      . ...| | |.  | | |||      . ||  ..      |.   ||.|||||||||||
aaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gs.kvpivvhcsagigrtg

TFIAADMLMNAIQRSTATDyiDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
| .| . ... |          .   |  ||.||.  .|.  ||...||.||  
tivaieyilekiaenkpcp..pmpelvkalrdqrafsiqndvqylfihrvmlny

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 117-228 1.9e-16 54.4 In-house 90-198 (244) alignment
Range on Protein: 117-228
Range on HMM: 90-198/244.0
VARNARNDDKNRFRNILPYDYNRVQL-KGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEggktkCEHYWPTGQKP
 | |  |  |||    ||.|.||| | || .|| |||||..       .|| || || .|   || |. | .   .|.. .. |      . |||  .  
dafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdsepl

-HLHGNVTVTLVGS
     ..||||   
ewyeeditvtltdr

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 117-223 2.8e-08 26.9 In-house 21-98 (169) alignment
Range on Protein: 117-223
Range on HMM: 21-98/169.0
VARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINAsyiaddqgnrkyiatqgplpntidhfwEMVWETKASTIVMMtalveGGKTKCEHYWPTGQ
.|  . |. |||    |   . ||.|.    ..|.|||||                           .|.||| || ||..     |.    . .||  .
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....gdtddknnfwpeke

KPHLHGNVTV
   ||  | .
dyqlhpavil

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 117-223 3.5e-08 26.5 In-house 20-97 (169) alignment
Range on Protein: 117-223
Range on HMM: 20-97/169.0
VARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINAsyiaddqgnrkyiatqgplpntidhfwEMVWETKASTIVMMtalveGGKTKCEHYWPTGQ
.|  . |. |||    |   . ||.|.    ..|.|||||                           .|.||| || ||..     |.    . .||  .
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnfwpeke

KPHLHGNVTV
   ||  | .
dyqlhpavil

0037934 (Phosphotyrosine protein) phosphatases II 118-357 1.2e-71 236.4 In-house 5-241 (243) alignment
Range on Protein: 118-357
Range on HMM: 5-241/243.0
ARNARNDDKNRFRNILPYDYNRVQLKGevgNDYINASYIADDqgnRKYIATQGPLPNTIDH----FWEMVWETKASTIVMMTALVEGGKTKCEHYWPtGQ
|.   | .|||...|||||..|| |.|   .|||||..|      ...||||||||.|...    ||.|.|| . ..|||.| ||| |. ||..||| |.
allpenlsknrysdilpydhsrvkleg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.ge

KphLHGNVTVTLVGSKQTEHFIQRTLLIGK---KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQE-----DGALTGPIIVHCSAGIGRTGTF
.   .|..||||...........||||.     .. ...|.||.||.| ||||| |...|...| .|.   .|          ||..||||||.|||||.
v..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

IAADMLMNAIqrstatDyIDIAGTVAKLREQRTS-LVQTLYQYIYLHRIMLSL
|||....  .      . .|.  .|..|||||    |||. ||..|....| |
iaaylmllll......g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 118-355 2.1e-47 156.3 In-house 3-238 (239) alignment
Range on Protein: 118-355
Range on HMM: 3-238/239.0
ARNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNR-KYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQ
|..  |  |||. ||. ||..|| |.    .  .|||||||. | .|.   |||||| .  .   || |.|. .   |||.| |.|| | || .|||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

KphLHGNVTVTLVGSKQTEHFIQRTLLIGKKGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQeDGAltGPIIVHCSAGIGRTGTFIAADML
    . |. |||  ..    .| ||... . |   |  | .|..  | |.|||  .. .. |  ..   |   ||   | ..|||||.||||.|.  | .
s..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pga..rpwvihcsagvgrtgaflvidam

MNAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
.   ..  .   .||   |  .||.|  .|||  ||...|  .|
lrqakkqkt...vdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 119-355 2.2e-47 156.2 In-house 3-237 (239) alignment
Range on Protein: 119-355
Range on HMM: 3-237/239.0
RNARNDDKNRFRNILPYDYNRVQLK---GEVGNDYINASYIADDQGNR-KYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQK
..  |  |||. ||. ||..|| |.    .  .|||||||. | .|.   |||||| .  .   || |.|. .   |||.| |.|| | || .|||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

phLHGNVTVTLVGSKQTEHFIQRTLLIGKKGT--ELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQeDGAltGPIIVHCSAGIGRTGTFIAADMLM
   . |. |||  ..    .| ||... . |   |  | .|..  | |.|||  .. .. |  ..   |   ||   | ..|||||.||||.|.  | ..
..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pga..rpwvihcsagvgrtgaflvidaml

NAIQRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
   ..  .   .||   |  .||.|  .|||  ||...|  .|
rqakkqkt...vdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 119-355 2.7e-32 106.9 In-house 31-267 (285) alignment
Range on Protein: 119-355
Range on HMM: 31-267/285.0
RNARNDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIAD-DQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPH-
    | | ||. ..   .  || ||     ||| ||..    . .  ||.||||||.|.  || |... | . ..|. .|.|||  ||  |.|       
ayeanpdlnryadvrcieetrvvlknh.drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

LHGNVTVTLVGSKQT--EHFIQRTLLIGK----KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgaltGPIIVHCSAGIGRTGTFIAADM
  |.  .||   |.      |  .| . .        | . | |   | |.  |  . |.. |   ||    ..     || ||||||.||| ||.  | 
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke....kpicvhcsagvgrtatfvgidy

LMNAIQRSTATDYIDIagtVAKLREQRTSLVQTLYQYIYLHRIML
    |      . .||   | ..|  |   ||.  |...|. ...
atirimenpniemldi...vremramrfqavqshmqflflyvvlm

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 119-205 1.1e-08 29.0 In-house 30-118 (332) alignment
Range on Protein: 119-205
Range on HMM: 30-118/332.0
RNARNDDKNRFRNILPYDYNRVQLKGEVGN-DYINASYIADDQGNRKYIATQGPLPNTID-HFWEMVWETKASTIVMMTALVEGGKTKC
.   | | ||   .  .|..||.|  . |. |. |||..     .  || .| |. .  .  || || | | | |...  . |  | |.
kflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_ptpA1_pd Subfamily ptpA1 121-316 1.5e-42 140.8 In-house 45-257 (418) alignment
Range on Protein: 121-316
Range on HMM: 45-257/418.0
ARNDDKNRFRNILPYDYNRVQLKG---EVGNDYINASYIaDDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPT---GQK
 .|  |||. |||| .. |||||    . |.||||| || |    ...|.|||||||||  || |||| ..  |||..   |  . ||..|||    |..
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi.dgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

PHL-------HGNVTVTLVGSKQT--EHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQ---EDGALTGPIIVHCSAGIGRT
  .        |  .| ||   |      | | . .  .|    .|.|||  | || .|  | |.  ||. .    .          |||||||||.|||
fsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GTFIAADMLMNAIQ
||| .| ..|. ..
gtfctavimmkkld

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 122-355 4e-58 191.4 In-house 2-236 (237) alignment
Range on Protein: 122-355
Range on HMM: 2-236/237.0
RNDDKNRFRNILPYDYNRVQLKGEVG-NDYINASYIADDQG-NRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLHG
.|  |||. ||  ||..|| |||  .  |||||.|. . .|  .||||.|||| .. | ||.|||. | | |||.| |.|| . || .|||  ..|  .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

NVTVTLVGSKQTEHFIQRTLLIGKKGTELTV---THYQYLAWTDHGVPASTAPLVALLYQVKMTSQeDGALTGPIIVHCSAGIGRTGTFIAADMLMNaiq
 .||.|   ..   .  |.||. |..|   |     ||. .| |.|||  || |. .  ..   |.   . .|| |.|||||.|||| |.  | ..    
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsp.hvsesgpwiihcsagvgrtgiflvidamlr...

RSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
..     .||   |  . |.|  ..||  ||...|. .|
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

Y_phosphatase Protein-tyrosine phosphatase 123-355 1.1e-78 259.3 Pfam-A 1-234 (235) alignment
Range on Protein: 123-355
Range on HMM: 1-234/235.0
NDDKNRFRNILPYDYNRVQLKGEVG-NDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWP-TGQKPHLHGN
| .|||...||||| .||.|||. | .|||||.|.   . ..|.|||||||..||..||.|||. | ..|||.| |.| |..||..||| . ...  .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VTVTLV-GSK-QTEHFIQRTLLIGKKGTEL---TVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSqedGALTGPIIVHCSAGIGRTGTFIAADMLMNAI
..|.|.  .| ...... |.| . ||..|    .|....| .|.|||||.|. .|. |. .|. ..    | .||..||||||.||||||.|.|.|.. .
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

QRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
..      .|.  .| .||.|| ..||.| |||.|....|
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 123-355 1.1e-78 259.3 In-house 1-234 (235) alignment
Range on Protein: 123-355
Range on HMM: 1-234/235.0
NDDKNRFRNILPYDYNRVQLKGEVG-NDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWP-TGQKPHLHGN
| .|||...||||| .||.|||. | .|||||.|.   . ..|.|||||||..||..||.|||. | ..|||.| |.| |..||..||| . ...  .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VTVTLV-GSK-QTEHFIQRTLLIGKKGTEL---TVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSqedGALTGPIIVHCSAGIGRTGTFIAADMLMNAI
..|.|.  .| ...... |.| . ||..|    .|....| .|.|||||.|. .|. |. .|. ..    | .||..||||||.||||||.|.|.|.. .
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

QRSTAtdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIML
..      .|.  .| .||.|| ..||.| |||.|....|
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail

0041856 (Phosphotyrosine protein) phosphatases II 123-357 2e-49 163.0 In-house 1-170 (182) alignment
Range on Protein: 123-357
Range on HMM: 1-170/182.0
NDDKNRFRNILPYDYNRvqlkgevGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTalveggktkCEHYWPTGQkphlhgnvt
| ||||...|||||..|       ..|||||.... .. ....|||||||..|. .|..|..| . .|||..|         .|.|||.           
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell.........

vtlvgskqtehfiqrtlligkkgtELTVTHYQYLAWTDHGVPAsTAPLVALLYQVKMtsqedgaLTGPIIVHCSAGIGRTGTFIAADMLMNAiqrstatd
                        | ....|.|| | |||||  .  |.... .|.          ||..||||||.|||||..||....          
........................erlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl........

YIDIAGTVAKLREQRTSLVQTLYQYIYLHRIMLSL
 ...  .|. .|..|   |.|. ||..|....| |
gvsleeavklvrsrRpgmvitpnqyfflqlallel

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 123-350 9.4e-38 124.6 In-house 50-273 (301) alignment
Range on Protein: 123-350
Range on HMM: 50-273/301.0
NDDKNRFRNILPYDYNRVQLKGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLH-GNV
..||.|. ..       |..  .     | | .|  .   ...|||||||.|| . || |.   .  .|||..  ||  ..|||.| |.  . .|. |  
pkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

TVTLVGSKQ--TEHFIQRTLLIGKKGT---ELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQedgaltgPIIVHCSAGIGRTGTFIAADMLMNAIQ
..... ...   .. ..||| .          |||||||  |||.||| | | |  |.  || . .       ||.|||||||||. .||....| ....
kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigteylareve

rstATDYIDIAGTVAKLREQRTSLVQTLYQYIYL
   |   |... ....|||.| . |||  |  ..
...adptieltealkhlrehrwngvqtnsqlywm

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 123-357 4.9e-33 109.1 In-house 43-275 (312) alignment
Range on Protein: 123-357
Range on HMM: 43-275/312.0
NDDKNRFRNILPYDYNRVQLKGEvGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTG-------QKP
  | ||. ||  .|  |  | |.  | || | ..       ....||||| ||. |||...    ...|......|| |  || .|           .. 
fkdlnrypniqcwdrgrftlagd.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

HLHGNVTVTLVGSKQTEHFIQRTLLIGK--KGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQedgaltgPIIVHCSAGIGRTGTFIAADMLMN
     .|   .| |  ..  .| | .     | |  . |||. .| |||.| |      ||  ||   .       |.| |||||.|||||..  . .. 
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.......pviahcsagvgrtgtlaliesmia

AIQRSTATDYIDIagtVAKLREQRTSLVQTLYQYIYLHRIMLSL
|..     .  |.      || .|.  |... ||.|  |..| .
alrhprkqnvkds...fvllrkdrarsvrvfpqyvyalrcvlef

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 126-194 1.6e-11 38.4 In-house 40-116 (347) alignment
Range on Protein: 126-194
Range on HMM: 40-116/347.0
KN---------RFRNILPYDYNRvQLKGEVGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMM
||           | .|  .  . . . .  . |||||.|  |. ...|| || |||.|.  || ||  || . .| .
knrskdvklidatrvvlspeksk.nsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 133-260 1.7e-11 38.6 In-house 3-123 (130) alignment
Range on Protein: 133-260
Range on HMM: 3-123/130.0
LPYDYNRVQlkgevGNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEggktkCEHYWPTGQKPH-LHGNVTVTLVGSKQT
|.....|.|     ||.|||||..   .  ..|. || || .|  .|| |. |     .|.. .. |      . |||  .  .    ...|||   .. 
lefevsrlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrdef

eHFIQRTLLIG-KKGTE--LTVTHYQYLAWTD
 ..|. . | . ..  |   ..| .|   |  
.knikasnleiesdlneshqaltmfqisnwps

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 138-355 8.4e-25 82.5 In-house 33-257 (290) alignment
Range on Protein: 138-355
Range on HMM: 33-257/290.0
NRVQLKG---EVGNDYINASYIADDQGnRKYIATQGPLPNT-------IDHFWEMVWETKASTIVMMTALVEGGKT----KCEHYWPTGQKPHLH-GNVT
.|| |||      .||| |...   .|  . |.|| |. ..       | .|| |. . |.  .||.    |  .      |..| |.    .|  ...|
trvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkglt

VTLVGSKQTEHFIQRTLLIG-KKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKmTSqedgalTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStaT
|      . . ...|.|..   .. |.||||...  |..  |. .|  |..|. .|| .|      . |.||||  || |  .. | .. .  |  .  .
vkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as......ktpvivHcvdGiSrsAalaaiilgyQkiaet..s

DYIDIAGTVAKLREQRTSLVQTLYQYIYLH-RIML
. . ..  . .||.||  ....  .. .    |.|
gsvkledvlkalrkqralaitsalelafvdagivl

0044763 (Phosphotyrosine protein) phosphatases II 140-356 2.9e-32 107.1 In-house 10-169 (178) alignment
Range on Protein: 140-356
Range on HMM: 10-169/178.0
VQLKGEVGNDYINASYIADDqgnrKYIATQGPlpntiDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKphlhgnvtvtlvgskqtehfiqrtl
  | |. . ||||||.| ..     |.....|      ...|...| . ..||..|  .|.|. || .|||..                           
snleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.........................

ligkkgteltvTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDGaltGPIIVHCSAGIGRTGTFIAADMLMNAiqrstatdYIDIAGTVAKLREQRTs
            .|... . ||||| ... . ...  ..   .|.|   ||..||||||.||.||..||....           ...   .. .||.|  
...........iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaielvrerRp.

LVQTLYQYIYLHRIMLS
 |..  |. .|... | 
ivpnpgqlrqLyefelr

0046846 (Phosphotyrosine protein) phosphatases II 145-357 1e-42 141.2 In-house 9-172 (176) alignment
Range on Protein: 145-357
Range on HMM: 9-172/176.0
EVGNDYINASYIADDqgnrKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLhgnvtvtlvgskqtehfiqrtlligkk
. . |||||..|. .    ..||||||||.|. .|.||..| . ...|..| .|| |. || .|||  .|...                           
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

gteltvtHYQYLAWTDHGVPAStAPLVALLYQVKMTSQEDgaltGPIIVHCSAGIGRTGTFIAADMLMNaiqrstaTDYIDIAGTVAKLREQRT-SLVQT
       .|..| | ||||| . . |  || ...   .|.    ||..||||||||||||..||..|.           ...  ..|..||||    |||
.......qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllel.......ekglsveealalvreqRplgavqt

LYQYIYLHRIMLSL
  || .|.. .| |
peQyrflyefelll

0036282 (Phosphotyrosine protein) phosphatases II 147-352 3.4e-43 142.7 In-house 1-164 (174) alignment
Range on Protein: 147-352
Range on HMM: 1-164/174.0
GNDYINASYIADDQGNRKYIATQGPLPntidhFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTgqkphlhgnvtvtlvgskqtehfiqrtlliGKKGT
|.||||||..     ....||.||||.     ||||..| . .|.||.. ..| |..|| .|||.                               ..  
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

ELTVTHYQYLAWTDHGVPASTApLVALLYQVKMTSQEdgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQrstaTDYIDIAGTVAKLREQRTSLVQTLYQ
| .. .|.|| | ||||| ..  |  .. .|.   .|     ||..||||||.|||||..||....  .     ....|.  .|..|| ||   |||  |
erlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQ

YIYLHR
|..|. 
yrflyy

0043147 (Phosphotyrosine protein) phosphatases II 147-351 2.2e-41 136.8 In-house 4-154 (172) alignment
Range on Protein: 147-351
Range on HMM: 4-154/172.0
GNDYINASYIADDQGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALveggktkcehywptgqkphlhgnvtvtlvgskqtehfiqrtlLIGKKGT
|.|||||||.      ...|||||||.||...||.|..| . ..||..| |                                          |  ... 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpell

ELTVTHYQYLAWTDHGVPaSTAPLVALLYQVKMTSQED-GaltGPIIVHCSAGIGRTGTFIAADMLMnaiqrstatDYIDIAGTVAKLREQRTSLVQTLY
| .. .|.|| | ||||| ... |  .| ...   ... |   ||..||||||.|||||..||....           ...  .|| .||.|   ||.  
erlgiqylylpwpDhgvp.llellleflefidellalspg...gpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnps

QYIYLH
||..|.
qyrfly

0051429 (Phosphotyrosine protein) phosphatases II 148-358 4.4e-47 156.3 In-house 4-225 (272) alignment
Range on Protein: 148-358
Range on HMM: 4-225/272.0
NDYINASYIADDQG---NRKYIATQGPLPNTIDHFWEMvWETKASTIVMMTALVEGGKTKCEHYWP-----------TGQKPHLHGNVTVTLVGSKQTEH
..||||...    .    .......||||.|...|| . .| . .|||... ..| |. ||. |||           ..  ..|.|...|||.  .....
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FIQRTLLIG---KKGTELTVTHYQYLAWTDHGVPASTapLVALLYQVKMtsqedgalTGPIIVHCSAGIGRTGTFIAADMLMnaiQRSTATDYID-----
.| |.||.    . |. ..|.|..|..| ||||| ..  |..|| ..           ||..||||||..||||..|...|.   .. .... .|     
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvalllll...lgvsletivddYllt

---IAGTVAKLREQRTSLVQTLYQYIYLHRIMLSLI
   ....|..||.||   |||  ||..|....| |.
nlyleeaveelraqrpgavqteeqylflyeallell

0051082 (Phosphotyrosine protein) phosphatases II 148-353 4.6e-32 106.1 In-house 3-148 (151) alignment
Range on Protein: 148-353
Range on HMM: 3-148/151.0
NDYINASYIADDqgnrkYIATQGPLPntidHFWEMVWETKASTIVMMTALVEGGktKCEHYWPTGQkphlhgnvtvtlvgskqtehfiqrtlligkkgte
.||||.||. .      .....|||.    .|.|...| . .|||... ..| |  .| .|.|  .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

LTVTHYQYLAWTDHGVPASTAPLVALLYQVKMtsqedgaL-TGPIIVHCSAGIGRTGTFIAADMLMNAiqrstatdyIDIAGTVAKLREQRTSLVQTLYQ
..|.|...| |.|.|.| |.. ....| ..            ||..||||||.|||||..|.....           .... ... .|..|. .||.  |
ievlhipildwpdpglplsfdavleflellld.......kkngpvlvHCsaGkgRTGtlvalylmllg.........vsleealeeyrlkrpgvvqpnqq

YIYLHRI
...... 
flfqlfa

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 160-351 2.1e-25 84.0 In-house 2-197 (199) alignment
Range on Protein: 160-351
Range on HMM: 2-197/199.0
QGNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKP-HLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTE----LTVTHYQ
.|.|.||||| || .|.  ||.||||| .  |||.       ..    |||| .     .|...||         .   .|.. .. |       ..|||
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YLAWTDHGVPAStAPLVALLYQVKMTS-QEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStATDYIDIAGTVAKLREQRTSLVQTLYQYIYLH
. .| ..  |   | .| ..   .  | . .     |.||||| | | || |.| |. . . . |  |  .|.     .||. |  .. .| .| ...
ftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfiy

0049260 (Phosphotyrosine protein) phosphatases II 161-351 1.1e-39 130.9 In-house 7-143 (152) alignment
Range on Protein: 161-351
Range on HMM: 7-143/152.0
GNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWptgqkphlhgnvtvtlvgskqtehfiqrtlligkkgteltvtHYQYLAWTD
 ....||||||.|||...||.|..| ...||||.| |.| || |||.|.                                          .|..| | |
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpD

HGVPASTAPLVALLYQVKMTSQEDGaltGPIIVHCSAGIGRTGTFIAADMLMnaiqrstatDYIDIAGTVAKLREQRTSLVQTLYQYIYLH
|||| ..  |  ||  ..   ...|   ||..||||||.|||||..||....           ...  .|| .||.|   |..  |...|.
hgvpdlsqlllflllfieklaldkg...gpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 161-351 3e-25 83.6 In-house 2-196 (198) alignment
Range on Protein: 161-351
Range on HMM: 2-196/198.0
GNRKYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKP-HLHGNVTVTLVGSKQTEHFIQRTLLIGKKGTE----LTVTHYQY
|.|.||||| || .|.  ||.||||| .  |||.       ..    |||| .     .|...||         .   .|.. .. |       ..|||.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

LAWTDHGVPAStAPLVALLYQVKMTS-QEDGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStATDYIDIAGTVAKLREQRTSLVQTLYQYIYLH
 .| ..  |   | .| ..   .  | . .     |.||||| | | || |.| |. . . . |  |  .|.     .||. |  .. .| .| ...
tswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 164-241 2.4e-10 34.3 In-house 237-311 (440) alignment
Range on Protein: 164-241
Range on HMM: 237-311/440.0
KYIATQGPLPNTIDHFWEMVWETKASTIVMMTALVEggKTkCEHYWPTGQKPHLHGNVTVTLVGSKQTEHFIQRTLLI
 .|||| ||  |.  || .| . . |||.|.  | .  || |  |||   .    |  ||   ||.. .    ||| .
afiatqmpldstvldfwrlvhdyristiimlnqlnd..kt.csiywpvntrsvtfgpftvghkgsenmnrvkvrtlel

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 167-350 3.9e-26 86.7 In-house 39-213 (255) alignment
Range on Protein: 167-350
Range on HMM: 39-213/255.0
AtqgplpnTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQ--KPHLHG-NVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGV
        |.|.|....  ||....||.. . | |. ||..|.|. .  |  |.  |||.|   ..   . .. |. .|.|    ||.||.|  | ..  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PASTAPLVALLyQVKMTSQedgaltgPIIVHCSAGIGRTGTFIAADMLMNAIQ---RSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYL
|  .  .  .| .|   |.       ...||||.||||. .|. |...   .    . | |  .|    . .||..|.. ..|  |  . 
Pelareilnil.kvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafs

subfamily_hpo-7_pd Subfamily hpo-7 169-351 6.5e-23 76.0 In-house 42-220 (263) alignment
Range on Protein: 169-351
Range on HMM: 42-220/263.0
QgpLPNTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQ--KPHLH-GNVTVTLVGSKQTEHFIQRTLLIGKKGTELTVTHYQYLAWTDHGVPA
   | .||| |....  ||....||..   | |. ||..|.|. .  |  |.  ||..| | |.   . .. .  .|.| .  ||.||.|  | ..  | 
l..lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpe

STAPLVALLyQVKMTSQedgaltgPIIVHCSAGIGRTGTFIAADMLMNAIQ---RSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLH
 .   . .| .|   |.       ...||||.||||.  |  |...   .    . | |  .|    . .||..|.. ..|  |  .  
lareilnil.kvarnsk.......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 174-351 9.1e-16 52.2 In-house 102-281 (302) alignment
Range on Protein: 174-351
Range on HMM: 102-281/302.0
NTIDHFWEMVWETKASTIVMMTALVEGGKTKCEHYWPTGQKPHLH-GNVTVTLVGSK-QTEHFIQR------TLLI----GKKGTELTVTHYQYLAWTDH
.|.. .| .. . . . .| ....||... || .|. .  . .|. |. ||. |  | . |.|  .      |. |     || .. ||   .. || ||
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPASTAPLVALLYQVKmtsqedgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATDYIDIagtVAKLREQRTSLVQTLYQYIYLH
| |. . . . .|   .       .    ..||||||.|||||..|    ..  ..   || ..|   |  .|. |   ||.  | ||| 
Gapkeaytaldilkfce.......sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsi...vlpvrqcryGavqdeqqliyll

0048076 (Phosphotyrosine protein) phosphatases II 240-355 2.6e-23 77.7 In-house 37-140 (145) alignment
Range on Protein: 240-355
Range on HMM: 37-140/145.0
LIGKKGTELTVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgaltGPIIVHCSAGIGRTGTFIAADMLMNaiqrstatDYIDIAGTVAKLREQRTS
   ... | ....|.|| | ||||| ... | ..| ...   .|.    ||..||||||.|||||..||....           ...  .....|.||  
tselellerlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsqrpg

LVQTLYQYIYLHRIML
 |..  |...|..  |
avpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 241-352 3e-22 74.3 In-house 48-139 (144) alignment
Range on Protein: 241-352
Range on HMM: 48-139/144.0
IgkkgteltVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDgaltGPIIVHCSAGIGRTGTFIAADMLMnaiqrstaTDYIDIAGTVAKLREQRTSL
         ...|..| | ||||| ... | ..|  ..   .|.    ||..||||||.|||||..||....        .  ...  ..| .|..|   
e........giqylhlpwpDhgvpdllellleflefieealeeg....gpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrsrrpga

VQTLYQYIYLHR
|..  |...|..
vpnpgqlrfLle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 247-355 3e-17 57.4 In-house 214-341 (350) alignment
Range on Protein: 247-355
Range on HMM: 214-341/350.0
ELTVTHYQYLAWTDHGV---PASTAPLVA----LLYQVKMTSQEDGALTGPIIVHCSAGIGRTGTFIAADMLMN-------AIQRSTATDYI----D-IA
 . | . |.  | | ..   | |  . .     |. .    |  | | . ||.||||||.|||||... |.|..         ..|.  |.     | | 
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

GTVAKLREQRTSLVQTLYQYIYLHRIML
 .| .||.|| |.||.| |.|...  .|
iivnelrkqrismvqnldqfifiYeall

subfamily_CDKN3_pd Subfamily CDKN3 247-352 1.9e-07 24.8 In-house 99-190 (202) alignment
Range on Protein: 247-352
Range on HMM: 99-190/202.0
ELTVTHYQYlawTDHGVPaSTAPLVALLYQVKMTSQEdGALTgpiIVHCSAGIGRTGTFIAADMLMnaiqrstATDYIDIAGTVAKLREQRTS-LVQTLY
 |.| || .   .| .|| . |  . .| ..... .. .  |   .|||  |.||.   ||  .|.         |.|.   ...|||. . |  .||. 
glivhhypi...adglvp.diasclkileelrinlka.yrkt...lvhcygglgrsslviacllly.......lddtiepkdaidklrdlkgsraiqtvk

QYIYLHR
|| ||. 
qynylse

PTPc_DSPc_SM00012 249-355 1.4e-33 110.6 In-house 1-104 (105) alignment
Range on Protein: 249-355
Range on HMM: 1-104/105.0
TVTHYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDGAlTGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTatDYIDIAGTVAKLREQRTSLVQTLYQYI
||.||.|..|.||||| .. ... || .||   .. .  ..|..||||||.||||||.|.|.|.. ....|  . .||  .| .||.|| ..|||..||.
tvkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqyl

YLHRIML
.|.|..|
flyrall

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 249-355 1.7e-19 64.5 In-house 90-191 (440) alignment
Range on Protein: 249-355
Range on HMM: 90-191/440.0
TVTHYQYLAWTDHGVPASTAPLVALLYQVKmTSQEDgALTGPIIVHCSAGIGRTGTFIAADMLMNAIQRStatDYIDIAGTVAKLREQRTSLVQTLYQYI
|. .|.| .| |.|||  ..|.. .. .|.  |||  |  ||..|||||| ||||  || | ..   .||   | |||   .  .|..|  .|||  || 
tlkqyhyqgwpdkgvpkfagpvlkmiqdvn.esqek.agngpllvhcsagagrtgviiavdsilreakrs...dqidifsfinsmrnnrpqmvqtpeqya

YLHRIML
..|  .|
fvheavl

subfamily_PTPDC1_pd Subfamily PTPDC1 250-350 2e-09 32.2 In-house 83-168 (182) alignment
Range on Protein: 250-350
Range on HMM: 83-168/182.0
VTHYQYlAWTDHGVPASTaplvALLYQVKMTSQedGALTGPIIVHCSAGIGRTGTFIAADMLMNaiQRSTATDyidiagTVAKLREQRTSLVQTLYQYIY
...|.. .|.|.||.. .     .|  ||. ..      | . ||| || ||||  ||. .. .  .| || .      .. ..|..|.. .||  |   
iyvynf.gwkDygvasle....riLdivkvvaf..alqegkvavhChaGlGrtGvliacylvya..krltaek......aiklvrskrpksiqtreqvel

L
.
v

0038934 (Phosphotyrosine protein) phosphatases II 251-312 1.4e-09 33.4 In-house 80-139 (194) alignment
Range on Protein: 251-312
Range on HMM: 80-139/194.0
THYQYLAWTDHGVPASTAPLVALLYQVKMTSQEDGalTGPIIVHCSAGIGRTGTFIAADMLM
 .|  | . |.|.. |.. |   |  |.   .||    | . ||| ||.|||||..|| ...
ieylklpfpddgtvPsleillrfldlvdeflnedp..ggvvaVHCkaGlgRtGtlvaaYLiy

PTEN_1 258-326 1.3e-07 26.6 In-house 102-166 (196) alignment
Range on Protein: 258-326
Range on HMM: 102-166/196.0
WTDHGVPaSTAPLVALLYQVKMTSQEDGAlTGPIIVHCSAGIGRTGTFIAAdMLMNAIQrSTATDYIDI
..|||.| | . | . .....   ..|    . ..||| ||.||.|| .||  || . . .|| . ...
ieDhgap.slselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaa.yLmykgk.ltadeAlel

0048567 (Phosphotyrosine protein) phosphatases II 258-312 2.6e-06 21.9 In-house 45-101 (157) alignment
Range on Protein: 258-312
Range on HMM: 45-101/157.0
WTDHGvPASTAPLVALLYQVKMTSQEDGALTGPIIVHCSAGI---GRTGTFIAADMLM
. |.| | . | |. . ....   .      ..|.|||.||    |||.|.|.. ...
ffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlil

PTPc_motif_SM00404 269-320 2.2e-06 22.6 In-house 61-111 (140) alignment
Range on Protein: 269-320
Range on HMM: 61-111/140.0
PLVALLYQVKMTSQEDGALTGPIIVHCSAGIGRTGTFIAAdMLMNAIQRSTA
.|.. | .|.   ..  .  | ..||| ||. |..|.|.|  ||.  | |.|
klskyldkvldfienaekkggkvlVHCqaGvSRSatliia.Ylmryrqlsla

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 284-356 5.3e-11 36.4 In-house 261-342 (349) alignment
Range on Protein: 284-356
Range on HMM: 261-342/349.0
DGALTGPIIVHCSAGIGRTGTFIAADMLMNAIQ----RSTATDYI-----DIAGTVAKLREQRTSLVQTLYQYIYLHRIMLS
| . . ...|||||| ||||...  |.|.. ..     |   ..       |  .| .|| || |.|| | |.| ..  .| 
dtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

DSPc Dual specificity phosphatase, catalytic domain 284-324 3.4e-06 22.0 Pfam-A 69-110 (133) alignment
Range on Protein: 284-324
Range on HMM: 69-110/133.0
DGALTGPIIVHCSAGIGRTGTFIAADMLMN-AIQRSTATDYI
  .  . ..||| ||| |..|.|.| ...   .. . | ...
aeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv

DSPc Dual specificity phosphatase, catalytic domain 284-324 3.4e-06 22.0 In-house 69-110 (133) alignment
Range on Protein: 284-324
Range on HMM: 69-110/133.0
DGALTGPIIVHCSAGIGRTGTFIAADMLMN-AIQRSTATDYI
  .  . ..||| ||| |..|.|.| ...   .. . | ...
aeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv

subfamily_CDC14_pd Subfamily CDC14 287-313 2.2e-07 25.0 In-house 262-288 (328) alignment
Range on Protein: 287-313
Range on HMM: 262-288/328.0
LTGPIIVHCSAGIGRTGTFIAADMLMN
 .| |.||| ||.|||||.||. .. .
aeGaiavhCkaGLGrtGtLiacylmkh

subfamily_CG42327_pd Subfamily CG42327 288-354 2.1e-16 54.5 In-house 247-311 (319) alignment
Range on Protein: 288-354
Range on HMM: 247-311/319.0
TGPIIVHCSAGIGRTGTFIAADMLMNAIQRSTATdyIDIAGTVAKLREQRTSLVQTLYQYIYLHRIM
 ||..|||| |.||||. ||.|. .. .. |  .  .||  .|  .|..|.| |.|  || ......
qGPlvvhcsdGvGrtGlviasdiairsleeskrs..vdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_PTEN_pd Subfamily PTEN 291-327 3.7e-06 22.1 In-house 117-152 (184) alignment
Range on Protein: 291-327
Range on HMM: 117-152/184.0
IIVHCSAGIGRTGTFIAAdMLMNAIQRSTATDYIDIA
..||| || ||||. |.|  |... . ..|.. ... 
vvvHCkaGkGRtGvliva.yllkslllekaeealelf

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 292-354 3.4e-10 34.2 In-house 2-61 (69) alignment
Range on Protein: 292-354
Range on HMM: 2-61/69.0
IVHCSAGIGRTGTFIAADMLMNaiqRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRIM
.||||.| ||||||||  . |    |  .   .||   |  .|  |  .|    .||..|  .
vvhcssgtgrtgtfiaimvema...rikseklvdifnnvqymrkcrpmmvmneieyifihdal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 292-353 1.6e-09 32.0 In-house 1-59 (69) alignment
Range on Protein: 292-353
Range on HMM: 1-59/69.0
IVHCSAGIGRTGTFIAadmLMNAIQRSTATDYIDIAGTVAKLREQRTSLVQTLYQYIYLHRI
.||||.| ||||||||   .|  . |  .   .||   |  .|  |  .|    .|...|  
vvhcssGtGrtGtfia...imvemarikseklvdifnnvqymrkcrpmmvmneneymfihda