Gene SpurPTPRB-like-4 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTPRB-like
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP114_AA protein Get Run
SpurP114_AA_4240-4517 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 340-408 2.8e-07 23.8 Pfam-A 14-79 (85) alignment
Range on Protein: 340-408
Range on HMM: 14-79/85.0
NTGQVTWDIP---ESEYDFFEVTYSPDHGFTnspapiyrMDINENQTRV--EFSFIGILPDTNYNVTVVTVVGA
.. ...|. |   ..... .||.|... |           . . . .|   .. . |. |.|.|...| .| ||
tsltlsWsppkdgggpitgYeveyrekggge........ewkeftvprtttsvtltgLkpgteYefrVqavnga

fn3 Fibronectin type III domain 513-592 1.2e-07 24.9 Pfam-A 2-81 (85) alignment
Range on Protein: 513-592
Range on HMM: 2-81/85.0
PPVNIETADSQLTSLLIAWSDPG-NETMFDRYYVAYERADELGnfTEVGYLYPNVT-SIFLEGLTPRTEYLFNVSTVVGEGK
.| |.   . . ||| . || |  ..  ...| | |. ... .   .. .  |. | |  |.||.| ||| |.| .| |.|.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngage

fn3 Fibronectin type III domain 899-970 1.9e-06 21.1 Pfam-A 2-76 (85) alignment
Range on Protein: 899-970
Range on HMM: 2-76/85.0
SVSNVFLTSLDEITLIASWDPP---DVVTSSNEILLtLSTNSTE-VRSVNVSGNVTEFVFKCLEPETEYTVELVSL
...|. ...  . .|  ||.||   .   .. |. .  .....|  ....|... |..... |.| |||.... ..
aPenlsvsevtstsltlsWsppkdgggpitgYevey.rekgggeewkeftvprtttsvtltgLkpgteYefrVqav

fn3 Fibronectin type III domain 1088-1165 1.6e-08 27.8 Pfam-A 1-83 (85) alignment
Range on Protein: 1088-1165
Range on HMM: 1-83/85.0
SPPSSVTITAVSSRLIEIRWTPPP----NIAEMVLEYFDTESPSNTWEARIDNDG-MYDIHGLDADTSYTVRLSSVGRTGAGD
|.|. .....|.|. ....|.||.    .|    .|| ...... . | .....   . ..|| ..|.|..|. .| . | | 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp

fn3 Fibronectin type III domain 1272-1347 1.4e-09 31.1 Pfam-A 1-79 (85) alignment
Range on Protein: 1272-1347
Range on HMM: 1-79/85.0
SPPESLRVVDETITTLRIEWDSPA--SGLYRGFEVDISPPTALQ-ELPRIVGSDIRGFTFVGLMHNSEYTVSVTTIMGE
|.|| |.| . | |.|...|. |.  .| . |.||. .. .  . .  . | .. . .|. ||  ..||...|... |.
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga

fn3 Fibronectin type III domain 1437-1512 8.9e-10 31.8 Pfam-A 4-80 (85) alignment
Range on Protein: 1437-1512
Range on HMM: 4-80/85.0
DGLELESVGP--YSLDWKVDTsLNDLNYERLEVSYSPESSQT-DSPFDISRCTDgTFTLEGLQPDTEYSVSVTAISGDT
 .| ...|..   .| |.  .  .. .... || |......  .  |...| |. ..||.||.|.|||...|.|..|..
enlsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngag

fn3 Fibronectin type III domain 1530-1604 1.4e-07 24.7 Pfam-A 5-84 (85) alignment
Range on Protein: 1530-1604
Range on HMM: 5-84/85.0
QLHVVSLSSDEIALAWGPV----NNIQGYAVRLFNAIGIN-MRTLSLSANSMSATLDSLSPASNYSVQLIVMDTDGSRQT
.|.| . .|... | | |      .|.|| |.. .. | .  .. .......|.||  | | ..|....   ...|  ..
nlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

fn3 Fibronectin type III domain 1615-1687 2e-09 30.6 Pfam-A 2-76 (85) alignment
Range on Protein: 1615-1687
Range on HMM: 2-76/85.0
PPGPITLQSSTQTRLSFTWTPA---TSNFDSYELSISGGDMPEprpVGVVYPNEGNE--FEVGGLLPDTTYNVRIYSV
.|. ... . | | |...|.|     .....||.  .  . .|   . . . .....  ... || |.|.|..|...|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqav

fn3 Fibronectin type III domain 1711-1775 3e-07 23.7 Pfam-A 10-80 (85) alignment
Range on Protein: 1711-1775
Range on HMM: 10-80/85.0
VGSNQNLTVSWQVQ----EGAESYRLIYTTTNRN--TNSIARPATSTSITIDNLLFGAIYNFRLATIAADG
  .. .||.||.      .  ..|.. | ... .  .... .|.|.|| |. .|  |. |.||.... ..|
evtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag

fn3 Fibronectin type III domain 1907-1973 5.5e-06 19.6 Pfam-A 6-78 (85) alignment
Range on Protein: 1907-1973
Range on HMM: 6-78/85.0
VEISKVGTNSLEIIWKTD-----NVDEYLLHYSGPDGP--LMSDIVPYIEInYYTFGELTPGTQYSISVISLIN
. .| |...||.. |.       ... | ..|.  .|.    .  ||  .   .|. .|.|||.|...| .. .
lsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavng

fn3 Fibronectin type III domain 1991-2064 1.9e-06 21.1 Pfam-A 2-81 (85) alignment
Range on Protein: 1991-2064
Range on HMM: 2-81/85.0
PISNLVLTP-QENTINLTWTSP---STMYDGFLICWYSATTEDNKAWLDGDATTYPWVIS--TPNEEYVVSVATFVGDRE
...|| ... ......|.|. |   .  ..|. . . ...... . . . ..||.  ...  .|. ||...|..  |. |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngage

fn3 Fibronectin type III domain 2085-2156 7.3e-07 22.4 Pfam-A 6-73 (85) alignment
Range on Protein: 2085-2156
Range on HMM: 6-73/85.0
LILKDIATDTISVSWVTIP----GVVDYTLSYSPPDGNE-QATQDIDESsaiaeglnnIYYVNFTGLTPGREYTFTV
| .... ......||   .     .. |.. |.. .|.|   .......          . |..|||.||.||.|.|
lsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprt.........ttsvtltgLkpgteYefrV

fn3 Fibronectin type III domain 2268-2345 7.4e-11 35.2 Pfam-A 2-80 (85) alignment
Range on Protein: 2268-2345
Range on HMM: 2-80/85.0
PVNNVTLDDSTIFTLTISWENP--IDGSFNMFLVEYAPVRSPDsvmA----LDPINmgTNTAIIPNLQPGTLYNIMVYALAGEE
.. |..... |  .||.||. |   .| .  . |||.......   .      | .  |.......|.||| |.. |.|. |. 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprt..ttsvtltgLkpgteYefrVqavngag

fn3 Fibronectin type III domain 2363-2430 6.9e-06 19.3 Pfam-A 5-73 (85) alignment
Range on Protein: 2363-2430
Range on HMM: 5-73/85.0
ELRLQTRTSTSISVSWGNTT--RPEVTGFVLRItfQEGDAIDSIKNVSLGDVL-GVEFSDLIPGTNYTVYL
 |..  .||||...||   .  . ..||. ..   .| .  .  |....      |....| |||.|.. .
nlsvsevtstsltlsWsppkdgggpitgYevey..rekgggeewkeftvprtttsvtltgLkpgteYefrV

fn3 Fibronectin type III domain 2638-2713 3.3e-06 20.3 Pfam-A 11-83 (85) alignment
Range on Protein: 2638-2713
Range on HMM: 11-83/85.0
RRPTSFTIQITLPRRGRYRFLRLRVRRRSQGLDAgpDGDEFLIPTDACpEYTFNNLLPDTDYAVDVNTVAEDGRTE
...||.|.. . |. |.  . . .|. |..|     .  || .| ..  ..|...| |.|.| . | .| ..|  .
vtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprttt.svtltgLkpgteYefrVqavngagegp

fn3 Fibronectin type III domain 2730-2804 4.1e-08 26.4 Pfam-A 5-78 (85) alignment
Range on Protein: 2730-2804
Range on HMM: 5-78/85.0
DISFNEVTTTSISFAWGMVSaDTNGPFDFYLLNLKNELSIDVQNVQVNTSETREHTFIGLMPGELYRVELIVNSN
..|. |||.||... |   . | .||.. | . .... . .. . . ... |...|. || ||  |....   ..
nlsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavng

fn3 Fibronectin type III domain 2816-2888 1.6e-08 27.7 Pfam-A 1-80 (85) alignment
Range on Protein: 2816-2888
Range on HMM: 1-80/85.0
DKPTDIMLSDLTTTSLTIDWKAP---LTSYQGFRLCWA-YGE---TNSLELGPAVMERTLSDLEAGAEYLVSLAAVVGTG
..|... .|. |.||||. |..|      ..|... ..  |.   ...  . .  .. ||..|..|.|| ....|| | |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag

fn3 Fibronectin type III domain 2912-2982 8.2e-09 28.7 Pfam-A 7-77 (85) alignment
Range on Protein: 2912-2982
Range on HMM: 7-77/85.0
NITSFNTTAVSIVWGTD-IPLLDVSSYVVSYWETANNGSVQDISVDDPSQtDYTIDGLVPGTRYSFMVDALG
.... ..| ... |     .  ....| | |.|. ...  . ..|. ...  .|. || |||.|.| | |. 
svsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavn

fn3 Fibronectin type III domain 3200-3269 4.4e-11 36.0 Pfam-A 5-75 (85) alignment
Range on Protein: 3200-3269
Range on HMM: 5-75/85.0
DLQFTSIGRNYVVLTWDNP---AGMIDSYNISYYPVNDITklMFEVVQAAAESNVLRVDDLNEGMNYSFTVVS
.|...... ....|.|. |    | |..|.. | ....        ... . .. . . .|..|..|.|.| .
nlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqa

fn3 Fibronectin type III domain 3296-3358 5.7e-09 29.2 Pfam-A 6-74 (85) alignment
Range on Protein: 3296-3358
Range on HMM: 6-74/85.0
LNITAFDETTISIEWEQV-----DVEEYILSYDALEGGS-GNVTVQSTDPNSYTFTGLTPGTQYTIGVQ
|....  .|.....|.       ... | . |   .||.  .    . . .|.|.|||.|||.|.. ||
lsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVq

fn3 Fibronectin type III domain 3375-3443 8.8e-14 44.6 Pfam-A 2-73 (85) alignment
Range on Protein: 3375-3443
Range on HMM: 2-73/85.0
PPTNLRTTMVAAQSITVSWDPPS--EGGSDTYNITYNVTGGQP-PSPHTVSTSETSVTFSNLTPLTEYFFTI
.|.||. . | . |.|.||.||.  .|  . |...|  .||.  .   ||. ..||||...|.| ||| |..
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrV

fn3 Fibronectin type III domain 3468-3541 1.6e-08 27.7 Pfam-A 6-79 (85) alignment
Range on Protein: 3468-3541
Range on HMM: 6-79/85.0
LAVTPEDNTEFTVSWEDLD--TEAFEQYCVMYEPYEAQEnrQQESFPVARNIRSARFYGLDPGQEYTVYVTSCSSV
| |..  .|..|.||.  .   . .. | | |.. . .|  .  .| | |. .|. . || ||.||.. |.... .
lsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavnga

fn3 Fibronectin type III domain 3656-3726 2.3e-10 33.6 Pfam-A 1-76 (85) alignment
Range on Protein: 3656-3726
Range on HMM: 1-76/85.0
DPPQNLVISEIGEDTATLSWADPA--EMNFDILEVVMTTM--PA-TKTTILKLNTNTVELTNLVPGQTYTVQLASV
..|.|| .||......||||  |.  . ...  ||   ..  .  .|.  .. .|..|.||.| ||..|......|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav

fn3 Fibronectin type III domain 3754-3832 1.5e-10 34.3 Pfam-A 2-84 (85) alignment
Range on Protein: 3754-3832
Range on HMM: 2-84/85.0
SPSDISVSNNELTRVTVTWQPS---EGVVARYSYTYGLPGSTV-TASETTTTTDTSIQLSNLTPSTRYEFRLWAESDQTEGSE
.|...|||..  | .|..|.|.   .| . .|. .|   |..  . . |.. | || .|..|.|.|.||||. | ....|| |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

fn3 Fibronectin type III domain 3869-3955 2e-07 24.2 Pfam-A 1-79 (85) alignment
Range on Protein: 3869-3955
Range on HMM: 1-79/85.0
SAVGGLTITKTGIVDAEVSWSSPLLPNGVIANYSLTIHISHDNGtlspygdtVTISAVAEQTEYSQDVIGLAAGQYYVFSVYATNQV
||...|... ..   ...||| |  ..| | .|...   . ...        .. .  .. |..|  . || .|. |.|.|.| |..
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge........ewkeftvprtttsvtltgLkpgteYefrVqavnga

0050432 (Phosphotyrosine protein) phosphatases II 4230-4517 1.1e-93 309.2 In-house 18-299 (308) alignment
Range on Protein: 4230-4517
Range on HMM: 18-299/308.0
PSTTHTRPTKKNMFAQHVAKmsARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLkGvAGTDYINASYIKDD--HGQKKYIAT
. .... ..    ..... |  | .. ... |.. |...   .  ..|.. .| |||||..|||||..|| | .  |.|||||||..    . ..|.|||
silvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.d.egsdYInAsyvdgyssklprkfIat

QGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG--EEPQLHGNVTVTLVGSNQTDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVP
|||||||.|.|| ||||.....|||.| ||| |. ||..|||    .... .|..||||.   . |... ||| |..  .| .|||||..|..| |||||
qgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvP

ESTAPLVGLLRQVKVTNQEdgaatGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
.|...|. .|..|. ....     |||||||||||||||||||.|.|.. ...      .|| ....|.||||.  |||. ||..|.|..| ..
pspeilldflelvrkslpg.....gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleyl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 4231-4519 1.9e-139 458.6 In-house 2-281 (288) alignment
Range on Protein: 4231-4519
Range on HMM: 2-281/288.0
STTHTRPTkknmfaQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKG---VAGTDYINASYIKDDHGQKKYIAT
...|..|.      ..|||.||||..|||.|||.|.|.|||..|||.|.|.|..|||||||||||..||.||.   .||.||||||||......||||||
epihispv......akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiat

QGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTA
||||..|...|||.|.||.||||||.|.||||||||||.|||....|...|.||||||.|.....|..|.|||||..||...|.||||||.|||||||.|
qgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeska

PLVGLLRQVKVTNQEDgaaTGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
||..|||||||.||.|   ||||.|||||||||||||||.|.|.||...   .||||||||.||.|.|||||||||.||.......||||||
pllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllsliee

0039614 (Phosphotyrosine protein) phosphatases II 4231-4517 7.5e-88 290.1 In-house 7-289 (297) alignment
Range on Protein: 4231-4517
Range on HMM: 7-289/297.0
STTHTRPTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTraVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG----TDYINASYIKDDHG-QKKYI
... . |.. ....... .. | .. ..  |. .|. .      . |.   | |||||..|||||..||.||.. |    .|||||||..  .  ..|.|
allesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfI

ATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKtKCEHYWPAGEEpqLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPES
|||||||.|.|.||.||||.....|||.| ||| |. ||..|||  ..   .|..||||..  . |... ||| ....| .|||||.||. | |||||.|
atqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvpps

TAPLVGLLRQVKVTNQEDgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
.. |  .|..|.  ..|.    ||..||||||||||||||||..... ...      .||  .....||||   |||. ||..|.. .| |.
lellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallell

subfamily_PTPRB_pd Subfamily PTPRB 4233-4519 1.7e-123 406.3 In-house 2-287 (293) alignment
Range on Protein: 4233-4519
Range on HMM: 2-287/293.0
THTRPTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQG
....|.|...|..||.||.|.....||.||..| |..|..||.||..|.|..||||.||||||..||.|   |. .|.|||||.||.. . ....|||||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPL
|||.|...||.||||...|.|||.|.|||.||.|||.|||| |||.|.|...|||| ........ |.|..||| .||.|..|....|.||||||.|..|
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

VGLLRQVKvTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
. ..|.|. ...|. |...|||||||||||||||||| |.|..||..   .||.|..|..|..||.|.|||||  |||..|..||.|...
ldfvrtvr.eaiektaskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcvldllrk

0045450 (Phosphotyrosine protein) phosphatases II 4235-4517 9.1e-88 290.2 In-house 6-304 (307) alignment
Range on Protein: 4235-4517
Range on HMM: 6-304/307.0
TRPTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEK--TRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG----TDYINASYI--------KDDHG
 .. .  .. ..|... . ...|.  |.. |. ...      ..|.   | |||||..|||||.|||.|. . |    .|||||||.        .  . 
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

QKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLE---KEGTERTVTHYQYLAW
..|.||||||||.|.|.||.|.||.....|||.| ||| |. || .|||  .|.. .||.||||.. .. |... ||| ..   ..| .|||||..|..|
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgw

TDHGVPESTAPLVGLLRQVKVTNQEDgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
 |||||.|...|. ....|.  ..|.    ||..||||||||||||||||..... ...   . ..|.  .....||||   ||.. ||..|.. .| |.
pdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell





subfamily_PTPRA_pd Subfamily PTPRA 4236-4515 7.8e-74 243.5 In-house 12-293 (330) alignment
Range on Protein: 4236-4515
Range on HMM: 12-293/330.0
RPTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLP
 |   . . . . . || .|  | .|.|.||| .   .. .| .  | .|||. ||||||..|| |   .||  .||||||.|.  . ..|.||.|||. 
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

NTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLE------KEGTERTVTHYQYLAWTDHGVPEST
.|.| || |.|| ...||||.| | |  ..||. |||  |    .||..|..  .. . ..  | .|..      .| ..| |. . . .| | |||  .
etvedfwrmiweqksativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

APLVGLLRQVKVTNQEDGAatgPIVVHCSAGVGRTGTFIAADMLMDAIQrstATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
  .. ||..|| .||  .    |||||||||||||||||. | ... ..   |   .|| ... ..| ||. .|||. || ......| 
iGmlkllkkvkklnqqsag...pivvhcsaGvGrtGtfivldavlervk...aerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 4236-4515 1.5e-62 206.5 In-house 8-282 (297) alignment
Range on Protein: 4236-4515
Range on HMM: 8-282/297.0
RPTKKNMFAQHVAKmsARNNAGFSDEYNNLPAMeKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGT---DYINASYIKDDHGqkKYIATQGPLP
||     ||  | |   |.   ||.|.. ||.  .... | |..  | .|.||.||||||  ||.|. |      ||.|||..|  .   ..|.|| | .
rpiplsdfatlvqk..nrhtdvfseeflclpea.niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmk

NTIEHFWEMVWENQTSTIVMMTALVEGGKtKCEHYWPAGEEPQlHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPE--STAP
.|.. || ||...|.|||||.. . |. | || .||.     .  |.|.|.|   ..   ||.|.| ..|.   ..| |  ||.. | |. |..  |.. 
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

LVGLLRQVKvtNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
|. |. .|.  .. .. | ||..|||.||||||| ... |  .  ..|   .. .|. |.. |.|..|  ||||  || ... .|| 
llklisevr..kdfsqnaegPllvhclaGvGrtgvlltidsvvaeakr...ekevdifglvkklrqerpylvqtkeqykfvyvavle

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 4236-4329 2e-13 44.3 In-house 3-95 (95) alignment
Range on Protein: 4236-4329
Range on HMM: 3-95/95.0
RPTKKNMFAQHVAKMSARNNAGFSDEYNNLPaMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGTDYINASYIKDDHGQKKYIATQG
.| .  .|  || .| .  .  | .|.. .. |    . |.     |  |||. ||.||| ||| |     .||||| ..     .. |||.||
kpihvsvfhshvlemhsnsdqefdnefksis.mtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaqg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 4236-4316 6.6e-10 32.9 In-house 4-84 (440) alignment
Range on Protein: 4236-4316
Range on HMM: 4-84/440.0
RPTKKNMFAQHVAKmsARNNAGFSDEYNNLPAMEKTRAVTAaRQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIK
||     ||..| .   |    | ||.. ||.   . .  |     |  |||||||| ||..|| |   |||  .||||||||.
rpiivadfadyvqn..nrrsrafedewsllpsglsqpsdia.slpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin

subfamily_PTPRD_pd Subfamily PTPRD 4237-4518 2.3e-100 331.9 In-house 4-282 (564) alignment
Range on Protein: 4237-4518
Range on HMM: 4-282/564.0
PTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMeKTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPN
| . . ...||||. | ... |. ||...    ..  ..||..  |  |||| ||..|| .|| |   .|. |.||||||.|.  . .|.||||||||..
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEePQLHGNVTVTLVGSNQTDNFIERTLLL--EKEGTERTVTHYQYLAWTDHGVPESTAPLVG
||| || ||||...|||||.| |.| ||.||..|||. . .. .|..||||. ...  ... ||. |  .|.   |.|..... .| |||||||...|. 
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

LLRQVKVTNQedgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
|.|.|. .|.     .||||||||||||||||||. |.... |.     . .|. ......|.||  .|||  |||..|...|  ..
lirkvralne...pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheaileala

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4237-4517 5.2e-73 240.8 In-house 3-283 (305) alignment
Range on Protein: 4237-4517
Range on HMM: 3-283/305.0
PTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTaaRQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPN
..  . .|... .... .. |.  .|..|.  |..  |.  ..  |  |||...| ..|  |..|.       .|||||||..  ...||||..||||.|
iialddlaayikearvysdkgleaqykslyeeeesidvg..kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEP-QLHGNVTVTLVGSNQTDNFIERTLLLEK---EGTERTVTHYQYLAWTDHGVPESTAPL
|.. ||....| ..|||||.| |||||| ||. |||  .   . .|...|.|  .... ..||| | . .   .  .|||..||   | |||||.... |
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

VGLLRQVKVTNQEDGaaTGPIVVHCSAGVGRTGTFIAADMLMDaiqRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
. |...|. . ..|     |..|||||||||||.||| |. ..   |  . . .||.. . ..|..|  .|||| || .||  .  ||
lslikrvqkdqkkdk..gvpllVhCsagvgRtGvfiavdiale...rlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli

0051299 (Phosphotyrosine protein) phosphatases II 4238-4517 8.6e-95 312.7 In-house 5-286 (288) alignment
Range on Protein: 4238-4517
Range on HMM: 5-286/288.0
TKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNT
 . . ....| |. |....|. .|.. |...  .. ..||.   | .||||..|||||..||.|. . |   .||||||||.  . ..|.||||||||||
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

IEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLE------KEGTERTVTHYQYLAWTDHGVPESTAP
.|.|| ||||.....|||.| ||| |..||..|||  .... .|..||||.   . |... ||| ..      ..|..|||||..|..| |||||.|. .
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

LVGLLRQVKVTNQedgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
|. .||.|.  ..   .  ||.||||||||||||||||.|.|.. ...      .|| ......||||  .|||. ||.......| ..
lldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 4238-4517 6.9e-78 256.9 In-house 9-290 (298) alignment
Range on Protein: 4238-4517
Range on HMM: 9-290/298.0
TKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEK---TRAVTAARQARNDDKNRYRNILPYDYTRVQLKG---VAGTDYINASYIKDDHGQKKYIATQGPL
. |... . .|.. . . .|...|...| ....   .   ..||. .| .|||| .|...|..|| |.       .||||||...  .|.. .||||.||
dlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPl

PNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVPESTAPL
..|.| || ||.|.. .||||.| |.| .|||...|||  |. . .|..||.|  ...  ..| |.| ..|  | .||.| . ..  |.|.|||| .  .
tetvedFWrmvteedigtiVmltnleeldktkyhkywPd.egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsv

VGLLRQVKVtNQEDgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
..|||.|.  .|.. |   |..|.|||||||.||||| | ... ....     .||  ..  .|..|. .|||  ||....  ||  .
ldllrkvra.sqqq.agnkpvivqCsaGvgRsGtfiaidsvlervkke...qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 4238-4519 4e-45 148.9 In-house 4-289 (305) alignment
Range on Protein: 4238-4519
Range on HMM: 4-289/305.0
TKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEH
..|.   . | .   .  ||.  |....  ..    . | ..|.. .||||...   |  ||.|.|    .|| | |.      |..| || || .|   
qqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcad

FWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHG-----NVTVTLVGS------NQTDNFIERT-LLLEKEGT-ERTVTHYQYLAWTDHGVPE
|| | ....  .| |.  |.| |  || .|... ....|.       ..| .  |      ....  ...| |..|  |.  | |||| .  | | ||| 
fwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa

STAPLVGLLRQVKVtnqedgaATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDyiDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
.   .. || . ..       . ||||||||||.||||. .  . ..| .      .  |    . ||||||   .||  ||...|. .|  ...
adlailellekarp.......skgpivvhcsagigrtgsvvmleyildqllagqiie..dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4240-4515 1.2e-56 187.1 In-house 4-277 (439) alignment
Range on Protein: 4240-4515
Range on HMM: 4-277/439.0
KNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARN--DDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNT
.. | .|| |.   ..  |....... ...   |. |.  |..  . ||||... ..|.||| |    ||  . |||| |||  . .| |||||||  .|
rdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

IEHFWEMVWENQTSTIVMMTALVEGGKtkcehYWPAGEEpQLHGNVTVTLVGSNQTDNFIERTLLL--E--KEGTERTVTHYQYLAWTDHGVPESTAPLV
 ..|| .|.|..|.||||.| |||  |     |||. .|   .|...|      .  |.. | . .  |  .   |||| ...|.|| |. ||  .. ..
tddfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl

GLLRQVKVTNqeDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQrstATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
 .|| .. .|  |   .||.||||||||||||| || |. .. ..   . . .|. | .  .|.||  .||.| ||.... .|| 
dflrainsan..dkeeygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 4241-4517 1.1e-86 285.7 In-house 5-280 (318) alignment
Range on Protein: 4241-4517
Range on HMM: 5-280/318.0
NMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEH
. ...||... .  .  .| ||..|   |.| . . . .  |  |||| |||.|| |||.|.   |. |.|||||.||   . .|.|||.|.|||.||| 
edleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieD

FWEMVWENQTSTIVMMTALVEGGKTKCEHYWPaGEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRQ
|| |||| ....|||.| ..| ||.|...||| ..... .|...|.|  . ...... |.. .....   .|.|  |.| .|.|.|||||.| |. |.||
fWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrq

VKVTNQEDGAatGPIVVHCSAGVGRTGTFIAADMLmdaIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
|. ..|. ||  |||||||||||||||.||| |.|   ..|  |   .|| .|. ..|||| |.|||  ||.... ..|  .
vskaqqksga..gpivvhCsaGvGrtGvfiavdil...lerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 4241-4518 3.1e-80 264.6 In-house 8-284 (319) alignment
Range on Protein: 4241-4518
Range on HMM: 8-284/319.0
NMFAQHVAKMSARNNAGFSDEYNNLPAMEKTrAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEH
. ..... .. .  . ..  |...|   ...  .. | . .| .||||.|||.|| |||.|   .|| |.||||||.|   . ..|.||||.|| |||| 
qeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentied

FWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTE---RTVTHYQYLAWTDHGVPESTAPLVGLLR
|| ||||...|..||.| ||| .| |...|||  |...  |...|||   ......| | | |.|  .|   |.|.|.||..|.||.|||..  |. ||.
fWrmvWeeessivvmltklveklkvklkkywpe.enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllk

QVKVTNQedGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
... . .  .   ||||||||||||||||||. |. .. ... ..   .||  |. ..| || ..||.  ||.... ..|  .|
rirksre..ktqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_PTPRG_pd Subfamily PTPRG 4241-4518 8.2e-80 263.6 In-house 4-288 (563) alignment
Range on Protein: 4241-4518
Range on HMM: 4-288/563.0
NMFAQHVAKMSARNNAGFSDEYNNLPAMEKTR--AVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG----TDYINASYIKDDHGQKKYIATQGPLPNT
. ||.|||.. | .. ||| |...|    ...   ......  |  |||| ||..|| .||.|....|     |||||.||.  . .|..|||||||..|
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

IEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLEK-------E-GTERTVTHYQYLAWTDHGVPEST
.. || |.||.....|||.| ||| |. ||. |||. .|..  |...|||. ....    .||| ...       .  ||..|..|.|  | ||||||..
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs

APLVGLLRQVKVTNQEdgaATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
.| .   .. . .|..   ..||||||||||||||||.|. | |.  ||.    . ..| |.. .|| ||  ||||  |||.|| ..|..| 
lpvLifvkkssaanka...eaGPivvHcsaGvgrtGtyivldtllkqiqqe...navnvfgflkhiraqRnflvqteEqYiflhdalleaia

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 4241-4514 6e-68 224.1 In-house 9-276 (315) alignment
Range on Protein: 4241-4514
Range on HMM: 9-276/315.0
NMFAQHVAKMSARNNAGFSDEYNNLPAMeKTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEH
. .  .||.  |  . || ..|...|   . . .  |..  | .|||| ||..|| .||||   .   ..||.||..|.    ...|||.|||...... 
dqlityvaqkkastkngfkqdyesipgg.qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkd

FWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGeePQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVK
|| .|.|.. ..|||.| |||| | |.|.|||      ..|..|||..  .. ...  |||    .   |.|  ..| .| | |||..| ||. | |.||
fwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvk

VTNQEDGaatGPIVVHCSAGVGRTGTFIAADMLMDaiqRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
. ....    |.||||||||||||||||. | ..|   .  | . |||   | ..|..|  .||.. || ... ..|
qhhtnsv...gaivvhcsaGvGrtGtfitldavld...qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 4241-4518 7.2e-66 217.0 In-house 5-284 (290) alignment
Range on Protein: 4241-4518
Range on HMM: 5-284/290.0
NMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGT-----DYINASYIKDDHGQKKYIATQGPLPNTI
. |...||.  |..| || .... | . |.  .|| .    |  .||..||..||  |. |. ..|      .||||.|||. . .|.|||||||..||.
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntl

EHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQlHGNVTVTLVGSNQTDNFIERTLLLEKEGT---ERTVTHYQYLAWTDHG-VPESTAPLVG
 .||...|..... |||.|  .| ||.||  |||. .  .  |.....|.  ......|||.| .... .   ...||.||  .| ..| |.. .. |. 
vdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

LLRQVKvTNQEDGaaTGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
. ...| |.  .|   ..||||||..|||...|.||..   .|..   .  |||   . . | |.  .|||  || .... ||. ..
ieemyk.tqrkrg..ntsivvHCSdtvgrsavfcaaat...tinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4241-4517 1.8e-63 209.2 In-house 5-278 (287) alignment
Range on Protein: 4241-4517
Range on HMM: 5-278/287.0
NMFAQHVAKMSARNNAGFSDEYNNLPA-MEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAgTDYINASYIKDDHGQKKYIATQGPLPNTIEHFW
..|.. |||  |..| ||.. .  |    ..   || .   .| ||||...||..|  || |||    |||||..|.  . .|..|....|. ||.  ||
ekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgeh.pdyinavfidgykekkafiiaesPmfntarnfW

EMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEpQLHGNVTVTLVGSNQTDNFIERTLLLE---KEGTERTVTHYQYLAWTDHG-VPESTAPLVGLLRQ
....... ..|||.. . |  . .| .||| ..   . |. ...|.  ......|||.| ..   |.|....|. ||. .| ..| |.|  . |. . ..
kliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem

VKVTNQedgAATGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
.|   .    . ..||||||..|||...|.||..   .|...     |||   . . | |.   |||  ||...   ||  .
yktqrk...rgntsivvhCsdtvGrsamfcaaat...tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 4242-4516 5.2e-47 154.9 In-house 13-282 (290) alignment
Range on Protein: 4242-4516
Range on HMM: 13-282/290.0
MFAQHVAKMSARNNAGFSDEYNN-----LPAMEKTRAVTAARqaRNDDKNRYRNILPYDYTRVQLKGVAGTDYINASYIKDDhgQKKYIATQGPLPNTIE
 | .  ...  .|  ... || .     ||.    | .  .    .  ||||...   | ||| ||     ||. | |.|    .  .| |||.| .|. 
afekfasdvvkknvdelakeyleklkpylpvqylerkifdkn..tefkknrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvi

HFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQL-HGNVTVTLVGSNQTDNFIERTLL---LEKEGTERTVTHYQYLAWTDHGVPESTAPLVGL
 .| || ......|||.  |.| ||.|||.|.|  |   |  |..||.   ... |. | . .|     ..| |  . |..  .| |. |. ||  |. .
diwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrt

LRQVKvtnqedgAATGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
|| ..        |.||.|||||||.||||||.| ..   ..|  .    .|.....  .|. |.  ||   ||. | . .| |
lrilr.......kasGpvvvhcsaGiGrtGtfvaiev...glqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

0040438 (Phosphotyrosine protein) phosphatases II 4243-4517 2.5e-89 295.0 In-house 5-276 (317) alignment
Range on Protein: 4243-4517
Range on HMM: 5-276/317.0
FAQHVAKMSARNNAGFSDEYNNLPAMEKTrAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNTIEHFW
. ... .. .... ....|...|. . .    . |.   | |||||..|||||..||.|. . |   .|||||||..  . ..|.||||||||||.|.||
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

EMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVK
.||||.....|||.| |.| |. ||..|||  .|.. .|..||||..  . .... ||| .|  .....|||||..|..|.|||||.|. .|. .|..|.
rmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

VTNQedgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTatdYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
  ..      ||..||||||||||||||||..... ...      .||  .....||||.  |||. ||..|.. .| ..
eale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleyl

0043336 (Phosphotyrosine protein) phosphatases II 4243-4516 1.1e-85 282.8 In-house 7-276 (278) alignment
Range on Protein: 4243-4516
Range on HMM: 7-276/278.0
FAQHVAKMSARNNAGFSDEYNNLPAMEKtRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNTIEHFW
........ . ...... |. .|. . .    . |.   | |||||..|||||..||.|. . |   .|||||||..  . ..|.||||||||.|.|.||
llkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

EMVWENQTSTIVMMTALVEGGKTKCEHYWPagEEPQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVK
.||||....||||.| ||| |..|| .|||  .... .|..||||.. .. |... ||| ..  ..| .||||||.||.| |||||||...|. .|..|.
rmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavr

VTNQedgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTatdYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
  ..      ||..|||||||||||||||...|.. ...      .|.  .....||||.  |||. ||..|.. .| .
eale...dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 4244-4519 1.5e-86 285.0 In-house 3-278 (281) alignment
Range on Protein: 4244-4519
Range on HMM: 3-278/281.0
AQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWE
 .|....|. .||||  ||..| |..   . ||...  |  ||||.||  || |||..   .    ||||||....  .|.|.|||||||.|.....||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLL-EKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVT
||||.. |.|||.|. .|.|| || .||| ...    |.|||. . .... ..|||.. | ...| .|.|.. .|.|| |||||..|. |..  ..|. .
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

NQEDGAatGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
....     |.|.|||||||||||.|| | |..|.....    .||  ..|..|..| |.|||. || .....||  ...
tekktk..aplvihCsaGvGrtGtyialDrlvkaveael..eeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_PTPRK_pd Subfamily PTPRK 4244-4515 5.1e-71 234.1 In-house 10-275 (314) alignment
Range on Protein: 4244-4515
Range on HMM: 10-275/314.0
AQHVAKMSARNNAGFSDEYNNLPAMektraVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGT---DYINASYIKDDHGQKKYIATQGPLPNTIEHFWE
 |..|.. . .. || .||..|.         ||..  | .|||. .||.|| .||.|. . |    |||||..|   .  ...|.|||||..|.. || 
lqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWr

MVWENQTSTIVMMTALVEGGKTKCEHYWPagEEPQLHGNVTVTLVGSNQTDNFIERTLLLEK----EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQV
.|.......|||.| ||| |. || .|||  |. . .|.. |.|| ..   ... |.. .||        |.| ..|.|.|.||.|| |   |..|.|.|
lvydencasivmltelvevgrvkClkyWP..edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrv

KVTNQEdgaATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
| ...|     |.|||||||| |||||||| |...| |.|    . .||  .. ..|...  .|.|  ||....  .| 
kksqee...eaGrivvhCsaGaGrtGtfiaidivldmiere...gvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 4244-4513 8.2e-61 200.9 In-house 11-284 (325) alignment
Range on Protein: 4244-4513
Range on HMM: 11-284/325.0
AQHVAKMSARNNAGFSDEYNNLPAMEkTRAVTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWE
 .|| |  |... ||. |.. ||. . . | ..| .  | .|||..|....| .|| |.     . .|||||||..|| ... ..|.| ||..||. .| 
vehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWr

MVWENQtSTIVMMTALVEGGKTKCEHYWPAG-EEPQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVK
.| . . ...|...  ...|| .|  |||    . .  | . | |.  ..  ... | | .   |.|  |.|  .|. .| | ||..  | |. .|. ||
lvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvk

VTNQEDG---AATGPIVVHCSAGVGRTGTFIAADMLMdaiQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
  ..       |..||.|||||||||||.||.   ..   ..      .|. | . |.|..|  .|.|  ||| .. ..
avservtantkastpilvhcsaGvGrtGvfislysal...akvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal

subfamily_PTPN9_pd Subfamily PTPN9 4246-4515 3.4e-72 238.0 In-house 6-288 (297) alignment
Range on Protein: 4246-4515
Range on HMM: 6-288/297.0
HVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVA---GTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMV
 || . .... | | || .. ... .  ..|...  |  |||| ..| || |||.|. |     .|||||...   . .| .|||||||..|.. || ||
lvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmv

WENQTSTIVMMTALVEGGKTKCEHYWPAGEE-PQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVK--
||... .|||.| .|| |. || .||| .||  . .|...|. |  ...... .|.| ..  |.. .|.|||.|.|.| |.|||.|.| |. .|..|.  
WeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrek

-------VTNQEDGAATG-PIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
       ..... | ..| |||||||||.|||||||. |. .. ...   .. .||  |. ..|.|||  .||  || . . .|| 
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee...vgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 4247-4515 9e-43 141.3 In-house 10-269 (288) alignment
Range on Protein: 4247-4515
Range on HMM: 10-269/288.0
VAKMSARNNAGFSDEYNNLPAMEKTRAVTAarQARNDDKNRYRNILPYDYTRVQLKgvA-GTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWEN
. ..     .|   ||.. |     .....     |  ..||.|.   |.|||.|.       ||.|  .   . ... | .| ||  ||| .|.|. |.
irlvlqiaveglkkeyrdspneasidiids..fianptrdryenlprcditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmlles

QTSTIVMMTALVEGGKTKCEHYWPA--GEEPQLHGNVTVTLVGSNQTDNFIERTLLL-EKEGTERT-VTHYQYLAWTDHGVPESTAPLVGLLRQVkvtnq
.   |||.. |.| || | ..|.|   ||. ..  . ||. .  .. |  .. .||  .||| |.  | .  .| | |.||||.  . . ||  .     
dveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....

edGAATGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
   . . |||||.|||||||||.|   .   |..    .|.. .   .|| ||.|   .||  ||.|.|| || 
..kslqkPivvhssaGvGrtgtlilili...aleslrlddflgirsllaklreerfkaiqtemqylyvhrcvle

0036941 (Phosphotyrosine protein) phosphatases II 4249-4517 9.4e-89 292.9 In-house 6-277 (297) alignment
Range on Protein: 4249-4517
Range on HMM: 6-277/297.0
KMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLkGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTS
.... ..|... |.  |. . .    ..|.  .| .||||..|||||.|||.| .  |.|||||||..  . ..|.||||||||||.|.|| ||||....
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

TIVMMTALVEGGKTKCEHYWPAG-EEPQLHGNVTVTLVGSNQ--TDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQED
.|||.| ||| |. ||..|||   .|.. .|..||||.. ..   |... ||| ...  .| .|||||..|. | |||||||.|.|. ....|.  ... 
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

--GaatGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
  |   ||..|||||||||.|||||||.... ..... .  .|.  .. |.||||.  |||| ||..|....| |.
psg...gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

subfamily_PTPN6_pd Subfamily PTPN6 4250-4519 1e-83 275.9 In-house 20-299 (306) alignment
Range on Protein: 4250-4519
Range on HMM: 20-299/306.0
MSARNNAGFSDEYNNLPAMEKTRA--VTAARQARNDDKNRYRNILPYDYTRVQL--KGVAGTDYINASYIKD--DHGQKKYIATQGPLPNTIEHFWEMVW
 .  ..|||..|...|  .|...    . .....|  ||||.||||.| ||| |  ..|.|.|||||.|||.     .|.|||||| |..|.. ||.|||
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

ENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLE---KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTN
....  |||.|  || || || .|||. || . .|...|| | .......| |.|...   |...||.| .|.. .| |||||...  .. .|..|.  .
qensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkq

QEDG-AATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
.|   | .||||||||||.|||||||  |.|.. |...     ||.  .. ..||||  ||||  || ......   ||.
eeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

subfamily_Ptp69D_pd Subfamily Ptp69D 4250-4516 4e-72 237.9 In-house 16-285 (307) alignment
Range on Protein: 4250-4516
Range on HMM: 16-285/307.0
MSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQ
     . |.  ||..|.| |  .  ... .  |  |||| .| ..| |||.|| . |   .||||||.||  . .||.|| |.|. .||. || |..| .
rkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

TSTIVMMTALVEGGKTKCEHYWPAGEEPQlHGNVTVTLVGSNQTDNFIERTLLLEKEG-------TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVT
  .|||.. | |  . ||..|||  .| | .|.. |.|| .......|.|.| . | .        .| |. |.|..| |  |||..  |. |..||.  
vtlivmlsnlteknrkkcakYWpiedevq.ygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

NQEDgaaTGPIVVHCSAGVGRTGTFIAADMLMdaiQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
.. .    .||||||||||||.|.|.| |.|.   |.  | | .|.  |. ..|.|| |||| | ||..|.| .|  
ykln...rsPivvhCsaGvgrsgifvaldsll...qqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 4250-4513 2.1e-46 153.0 In-house 9-289 (301) alignment
Range on Protein: 4250-4513
Range on HMM: 9-289/301.0
MSARNNAGFSDEYNNLPAMEKTRAVTAArQARNDDKNRYRNILPYDYTRVQLKGVA-----GTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWE
. | .. .|...|..|  .|. ...    . .|   ||..|| .||  |. ||         ..|||||||..   .||.||.|||. .|.  || ..|.
vaakhsnkfeeqykelkegedksctvgl.seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

NQTSTIVMMTALVEGGKTKCEHYWPAGEE-PQLHGNVTVTLVGSNQTD-----------------NFIERTLLLEKEGTERTVTHYQYLAWTDHGV-PES
.....|||.| | || |.|||.||| .|.  .  |..||||| ..                    ..|||..  ... . ..|. .|   | ..|| .| 
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

TAPLVGLLRQVKVTNQedgAATGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
   |  .  ... ...      ||.|||||..|.|.|.... ..   ..    |   .|| . .  .| ..   |.|| ||. ..  .
rtvLqviddvihrqqk...igggpvvVHCSdtVsrsGvYcsvsi...glEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi

0047943 (Phosphotyrosine protein) phosphatases II 4251-4517 2.8e-89 294.5 In-house 7-272 (273) alignment
Range on Protein: 4251-4517
Range on HMM: 7-272/273.0
SARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLkGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTI
.. .....  |.. |. . .    ..|.  .| |||||..|||||..|| | |  |.|||||||..  . ..|.||||||||||.|.|| ||||.....|
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMMTALVEGGKTKCEHYWPAGEE--PQLHGNVTVTLVGSNQTDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQED--G
||.| ||| |. ||..|||  ..  .. .|..||||.. .. |... ||| |..   | .|||||..|. | |||||.|...|. ....|. .....  .
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

aatGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
   ||.||||||||||||||||.|.|.| ...      .||  .....|.||   |||. ||..|....| ..
...gpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4251-4514 9.2e-70 230.0 In-house 14-274 (315) alignment
Range on Protein: 4251-4514
Range on HMM: 14-274/315.0
SARNNAGFSDEYNNLPAMEKTRaVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQT
  |. | ||.|...||  .  |  ..||.  |  ||||.||||.| .||.|         |||||||||  . .| |||.||||. ... ||.||.....
knrhtalfseefhdlpdPdiyr.qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekv

STIVMMTALVEGGKTKCEHYWPA-GEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTnqeDGAA
.||||.| . || | ||  |||    .    |.. |.|.  ... . . | | . |  . |||| .|.  | |.||.. |. |. |...||     .|  
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad...ngkk

TGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
. ...||||||||||| .|..|  .. |.|   |. .||  .. ..|..|  ||||  .| ... .||
efsllvhcsaGvGrtGvvisidevvaqikr...trsvdvfnfvknlrakrpylvqteeeyafiydavl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 4251-4514 1.9e-52 173.0 In-house 15-233 (392) alignment
Range on Protein: 4251-4514
Range on HMM: 15-233/392.0
SARNNAGFSDEYNNLPAMEKTrAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQT
  | .| |..|. .||  .     |.|..  |  ||||.|||||| .||.|     .. .||.|||||.  . .| |||.||| . ... ||.||.....
knrhsalffeefhdlpgpdiy.pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenv

STIVMMTALVEGGktkcehywpageepqlhgnvtvtlvgsnqtdnfiertllleKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVtnqEDGAAT
.||.|.| | ||                                          |    |||. ...  | |..||. |. |. ....||.   . |  |
ttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka...dfGqyt

GPIVVHCSAGVGRTGTFIAADMLMdaiQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
 |...||||||||||  |. | ..    ..  |  .||   ...||..|  .|||  || ... .||
hpliihcsagvgrtgvvisidsvv...ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 4252-4514 1.4e-68 226.3 In-house 14-273 (515) alignment
Range on Protein: 4252-4514
Range on HMM: 14-273/515.0
ARNNAGFSDEYNNLPAMEkTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTS
.|. . ||.|...||  .     | |..  |  ||||.|||||| .||.|   .     ||.|||||.  . .| |||.|||.. ... || .|......
nrhttlfseefhdlpgpn.iypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvt

TIVMMTALVEGGKTKCEHYWPA-GEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVtnqEDGAAT
||.|.| | || | || .|||    .    |.. | ||  .   . | |.| . |.   |||| ...  | |.|||. |  |. |...||    . |  |
tiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevka...dhgqyt

GPIVVHCSAGVGRTGTFIAADmlmDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
 |...|||||||||| .|..|   . . .   |. .||  .. .||..|  ||||  || ... .||
hpliihcsaGvGrtGvvisid...svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 4252-4514 1.5e-58 193.0 In-house 5-263 (283) alignment
Range on Protein: 4252-4514
Range on HMM: 5-263/283.0
ARNNAGFSDEYNNLPAMEKTRAVTAARQarNDDKNRYRNILPYDYTRVQLKGVAGtDYINASYIK---DDHGQKKYIATQGPLPNTIEHFWEMVWENQTS
. ||  | . ...|   ..   ...|..  |. |||...|.|.|  ||.||  .  |||||..|    ... .||||..|.|| .|.  || ||.... .
vnnnklfrevlkrlsvpdldadiasade..nkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

TIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTE---RTVTHYQYLAWTDHGvpeSTAPLVGLLRQVKVTNQEDGA
.|||.| | |. . ||  |||  .  . .|. ||||      . || . ||| ....      ..|||.  |.. |     |..  |..  ||  .    
aivmltklqedlrikCsqyWPk.rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg...eqaiinslvkfnkvislqtes

ATGPIVVHCSAGVGRTGTFIAAdmlMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
  ||||||||.|.|||..||||   . ...   .   .||  ..  .||||  .|||| ||  .|  ||
kkgPivvhCstgiGrtavfiaa...sasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 4252-4518 1.9e-19 64.2 In-house 20-286 (302) alignment
Range on Protein: 4252-4518
Range on HMM: 20-286/302.0
AR--NNAGFSDEYNNLPAMeKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAgTDYINASYIKDDHGQKKYIATQGPLPNTI---EHFWEMVWENQ
 .  ..|   .|.... .| |. .       .| .||.  ..  .| ..|.|.. .  .|.||| ..  . ... | .| |  ..    |.|| ||....
vksldtaevkkefkkidtm.kvdlekCkafkknlkknqsedvpildsnlvkleaep.dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqek

TSTIVMMTALVEGGKtKCEHYWP-AGEEPQLHGNVTVTLVGSNQTDNFI-ERTL-LLEKEGTERTVTH-YQYLAWTDHGVPESTAPLVGLLRQVkvtNQE
  ..|..    |  |   ....|   .. . .|.. |     .....   . .. .| .. ..  ..  |    | .. ||.. | |.    .|    ..
ivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv...fak

DGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDyidVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
.  |. ..|.    |.|| |.|... . .. .|.. .     .. ....||.||.  |..| ||. |....| .| 
kikadentvivSknGaGRagafltlavaveklqkgkepn...ikeivksiRsqRpravdslkQyvslyialllyik

subfamily_CG7180_pd Subfamily CG7180 4253-4515 6.1e-50 164.5 In-house 14-288 (296) alignment
Range on Protein: 4253-4515
Range on HMM: 14-288/296.0
RNNAGFSDEYNNLPAMEKTRAVTaARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTST
. .. .  |..  | .|     . . .. | .|||. ...||||.|| |. . |   .|||||.|.     .|.|| |..|  .|.. ||..|.....|.
kfrveyklelkltprleigdCag.glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

IVMMTALVEGGKtKCEHYWPAGEePQLHGNVTVTLVGSNQTDNFIERTLLLEKE------------GTERTVTHYQYLAWTD-HGVPESTAPLVGLLRQV
.|..|   .  | ..  |||     . .|.. | .| ..|  |.  ||. | |.              .|.|...|.  |   . || ||. |. |.|.|
vvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

KVTN--QEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
..     ..   .||.||..| |..|.| ..|.|. .. ...   .. .|| . . ..|..|  ||..  .| |.  ..| 
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvek...eeevdvFeavktlrrsRpqLvenveeYkyiYdvlle

subfamily_PTPRN_pd Subfamily PTPRN 4254-4513 3.8e-56 185.0 In-house 27-288 (297) alignment
Range on Protein: 4254-4513
Range on HMM: 27-288/297.0
NNAGFSDEYNNLPAMEKTRAVT-AARQARNDDKNRYRNILPYDYTRVQLKGVA---GTDYINASYIKDD-HGQKKYIATQGPLPNTIEHFWEMVWENQTS
|.  .. |.. | | |   ... .|.. .| .|||....|||| .||.||  |    .|||||| | |.   .  ||||||||..|. .||.||||. . 
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

TIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSN-QTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQedGa
 ||..| | | | ..|..|||  |  ....   | ||     .|... |.. |        |||| . .|.|...||| |. .|. . |.|  . .  | 
vivnltrleeegvkqckrywpd.eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..G.

ATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
 . |||||||.|.||||..|. |.... ...      ||.| |. ..|.||. ||.|  |. .   .|
rscpivvhcsdGaGrtGvyilidlvlnrllkGv..keidiaatlehlrdqrpglvktkdqfefaltav

subfamily_PTPN23_pd Subfamily PTPN23 4255-4516 2.2e-64 212.0 In-house 14-279 (288) alignment
Range on Protein: 4255-4516
Range on HMM: 14-279/288.0
NAGFSDEYNNLPAME--KTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVaGTDYINASYIKDD-HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIV
....  ....|   .  ..|  . |   .. .|||.|.||||| .||.|.|    ||||||..||   |  ..||||.||..|.  || ||.|...|.||
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgs.kDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviV

MMTALVEGGKTKCEHYWPAG-EEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGT--ERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKV-TNQEDGAAT
|..   | ||.|...|||.  .|.. .|...|||   ..|....||.| || ...   ..|.| |. .|...|||.|   |. .| .|.   ...   . 
mllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksk

GPIVVHCSAGVGRTGTFIAADMLMDAIqrSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
 |.||||||||||||.|      . ..  ..    .|.   . ..||||   ||.  |.  .   ||  
tPlvvhCsaGvgRtgvfalvyaavrel..ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4256-4514 2.1e-44 146.3 In-house 11-266 (281) alignment
Range on Protein: 4256-4514
Range on HMM: 11-266/281.0
AGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKG----VAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIV
  | .|. |||    .  .|.  |  |. |||| ||   | .|||||        |||| | ||.    .. || ||||  .|   || |.|...|..||
ddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MMTALVEGGKTKCEHYWPAGEEPQLH-GNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKvtnqedgAATGPI
|.  ..|  . ||  |.|      |.  ...|.   |     ..   | |  ||  | .||. .  | |  ||||.  .. .||...       | . | 
mlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir.......arstpp

VVHCSAGVGRTGTFIAADMLMDAIQRSTAtdYIDVAGTIAKIR-EQRALLVQTLYQYIYLHRTVL
|.||||||||.||..| .. ...|.   .    |.   ....|   ||  |||| ||. . . .|
vihcsagvgrsgtlmaveialqsihshft..lpdikqivshlrvtgraasvqtlqqymliwkvll

0045098 (Phosphotyrosine protein) phosphatases II 4257-4517 1.1e-78 259.7 In-house 8-272 (278) alignment
Range on Protein: 4257-4517
Range on HMM: 8-272/278.0
GFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQlkgvagtDYINASYIKDDhgQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTAL
 .. |. .|...     .| |    | |||||..|||||..||        ||||||||.    .||.||||||||.|...||.|.||.....|||.| |
dlllefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltel

VEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLE------KEGTERTVTHYQYLAWTDHGVPEST--APLVGLLRQVKVTNQE------
||.|. ||..|||  .... .|..||||.   ..|... ||||..      .....|.|||..|| | |||||...  ...  ||....  ...      
velgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------DGaatGPIVVHCSAGVGRTGTFIAADMLMDAIqrstaTDYIDVAGTIAKIREQRAL-LVQTLYQYIYLHRTVLSLI
       .|   ||..||||||||||||..||..... .      . .|.  .....|.||    ||.| ||..|.. .| |.
sslllldsg...gpvlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4257-4517 1e-49 164.2 In-house 17-277 (307) alignment
Range on Protein: 4257-4517
Range on HMM: 17-277/307.0
GFSDEYNNLPAMeKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKG-VAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTA
 . ||...|  . .  .||.     | |||||...   | .|. .|   . .||| | |.      ||.|..|||| ||. .|| |. ...  ...|.  
alvdefrvlakk.tpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

LVEGGKTKCEHYWPAGEEPQL-HG----NVTVTLVGSNQ---TDNFIERT-LLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVtnqEdgaa
..| .| ||| |||. |  .| .|     ..|. .|...    ...|. | | ..  .  ||..|.|.  | |.|||.     . ||  |.    .    
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry...d....

TGPIVVHCSAGVGRTGTFIAADMLMDAIQRStaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
| |.||||||||||.|| .|  ...| . .    .  |.   . ..|.||   .|| .||.|||| .|.  
tnpvvvhcsaGvGrsGtivaislvqdkmiaG..inckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 4257-4513 5.9e-41 135.2 In-house 7-255 (267) alignment
Range on Protein: 4257-4513
Range on HMM: 7-255/267.0
GFSDEYNNLPAMEKTRAV-TAARQARNDDKNRYRNILPYDYTRVQLKGVaGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTA
 .  |....  . .|..  .      |...||. . |||| ||| |.     .||||||..  . ....|.||.|| ||| .|.... ... ..||..| 
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

LVEGgktKCEHYWPAG-EEPQLHGNVTVTLVGSNQTDNFIERTLL-LEKEGTERTVTHYQYLAWTDHGVP-ESTAPLVGLLRQVKVTNqedGaaTGPIVV
  ..   .   .||    . . . ..||     .. ...   ||    |. . . || | |  |           ||.|.| . .. |   |    |.||
vftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlen...g..nrPlvv

HCSAGVGRTGTFIAADMLmdaIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
.||.||||.|||. .|     ..|    .  |.   . |||.||  ||.|. .|||.|...
acsdGvGrsGtflvidsq...leraktegvsdifdflrkirsqriglvdtkeryiyihell

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 4257-4516 1.9e-31 103.8 In-house 28-289 (310) alignment
Range on Protein: 4257-4516
Range on HMM: 28-289/310.0
GFSDEYNNLPAMEKtRAVTAARQARNDDKNRYRNILPYDYTRVQLKG--VAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMT
|.  .| .| | .   ..|     ..  |||| ...  | .||.||       ||| | |.| .. .. .| .||||  ||  || |...... .|... 
glvkqyrkldakqd.ssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

ALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQT--------DNFIERTLLLEKEG---TERTVTHYQYLAWTDHGVPESTAPLVG--LLRQVKvtnq
  .| |. ||  |||.    . .| . || ..              |.   . ....     |  |.  ..  | | |||.     |   || ||.    
kvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr....

edgaaTGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
      || |||||||..|... .| ..   .|...   ...|.   ..... .||  .||  ||....|  . .
.....hgpcvvhcsagkdrlyvvvalkl...kidkldrglkvdaeevktellksraiciqtelqyliidrvriif

0046845 (Phosphotyrosine protein) phosphatases II 4258-4517 7.5e-91 299.7 In-house 2-274 (284) alignment
Range on Protein: 4258-4517
Range on HMM: 2-274/284.0
FSDEYNNLPAMEKTR--AVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG----TDYINASYIKDD-----HGQKKYIATQGPLPNTIEHFWEMVWENQ
. .|.  |. .  ..   ...|.   | .||||..|||||..|| || . |    .|||||||..       . .||.||||||||||.|.|| ||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLEK---EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEd
...|||.| ||| |..||..|||  .|.. .|..||||.  .. |... ||| |..   .| .|||||..|..| |||||.|...|. .||.|.  ... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.

GAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
    |||||||||||||||||||.|.|.. ...   .  .|| ......||||   |||| ||.......| ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

DSPc_SM00195 4258-4517 1e-87 289.1 In-house 2-262 (263) alignment
Range on Protein: 4258-4517
Range on HMM: 2-262/263.0
FSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGV---AGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMT
.. |...| ...... .| |.. .| .||||.|||||| |||.||      |.|||||.||| .. .|||||||||||.|.|.||.||||.....|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

ALVEGGKTKCEHYWPAG-EEPQLHGNVTVTLVGSNQTD-NFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaaTGPI
  .| ||.||..|||   .... .|...|.||  .... ..| ||| |.|||  ..|.||.||| .|.|||||.|| ... |||.|| ....    .|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

VVHCSAGVGRTGTFIAADMLMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
||||||||||||||...|.... ... .    .|.  .. ..|.||. .|||| ||.......| .|
vVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 4258-4517 1e-87 289.1 In-house 2-262 (263) alignment
Range on Protein: 4258-4517
Range on HMM: 2-262/263.0
FSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGV---AGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMT
.. |...| ...... .| |.. .| .||||.|||||| |||.||      |.|||||.||| .. .|||||||||||.|.|.||.||||.....|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

ALVEGGKTKCEHYWPAG-EEPQLHGNVTVTLVGSNQTD-NFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaaTGPI
  .| ||.||..|||   .... .|...|.||  .... ..| ||| |.|||  ..|.||.||| .|.|||||.|| ... |||.|| ....    .|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

VVHCSAGVGRTGTFIAADMLMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
||||||||||||||...|.... ... .    .|.  .. ..|.||. .|||| ||.......| .|
vVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4258-4514 4.4e-70 230.9 In-house 7-265 (274) alignment
Range on Protein: 4258-4514
Range on HMM: 7-265/274.0
FSDEYNNLPAMEKTRAVtaaRQARNDDKNRYRNILPYDYTRVQLKGVAG----TDYINASYIKDDHG-QKKYIATQGPLPNTIEHFWEMVWENQTSTIVM
. .|. .||.  ... .   . ...  ||||..||| . .|| |.   .    ..|||| |||  .. .| |.|||||||||.. ||.|....... |||
lekeflelPlnfdqeel...dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

MTALVEGGKTKCEHYWPAGEEP---QLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDGAATGP
.| | |  ..||..|.|  |.    . .|.| .. .. ......  |.|.|..   ||.|.|| | .| || .|... .|. |...|. ...|. | ..|
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklap

IVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
.|||||||.|||| |||... .  ...   .  .|| ......| .|  .|||  || ..||.. 
vvvhCsaGiGrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 4258-4514 1.7e-68 226.3 In-house 36-288 (319) alignment
Range on Protein: 4258-4514
Range on HMM: 36-288/319.0
FSDEYNNLPAMEKTR-AVTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMM
.  |..... .       | |   .| ||||. |||..| ..|.|.   |. ..||||||...    ..||||.||||.||.. || |.|| ..||||..
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivll

TalveggKTKCEHYWPA-GEEPQLHGNVTVTLVgsNQTDNFIERTLLLEKE---GTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTN-QEDGAAtg
|      | ||  |||  ... . ...| |..|  ..|.... | . | ..      | .| . .| | |.|||.....|. |...|.  . .|.. |  
t......kdkcsqywplkivikeerfkvkvdsv..eetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra..

PIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
.|||||||||||||..|. |.|.| ...    . .||  ..  .|.||  ||| | || ... ..|
nivvhcsaGvGrtGvyivldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_PTPN14_pd Subfamily PTPN14 4258-4518 8.6e-64 210.4 In-house 25-297 (300) alignment
Range on Protein: 4258-4518
Range on HMM: 25-297/300.0
FSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVA--GTDYINASYIKDDHG--QKKYIATQGPLPNTIEHFWEMVWENQTSTIVMM
   ||...| ...   ...|.   | .|||....|||. .||.|.      |.||||| ||   |  ...||..||||..|.. ||.||||.... |||.
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TALVEGGKTKCEHYWPAGEEPQ---LHGNVTVTLVGSNQTDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDG----
|.  |.||.|. .|.|  |. .    .|.  ||   |...| .| ..| |.    . |||| | ||  |.||||||   . .  |..|.   ..      
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

--AATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
   .  |..|||||||||||  | .|.|. ...     . ||.  ..|..|||| |||||| || .......  ..
skeskPPvlvhCsaGvGrtGvlilsdlliatlehn...eeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_PTPN13_pd Subfamily PTPN13 4259-4518 1.4e-75 249.1 In-house 14-270 (273) alignment
Range on Protein: 4259-4518
Range on HMM: 14-270/273.0
SDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGtdYINASYIKDDHGQK--KYIATQGPLPNTIEHFWEMVWENQTSTIVMMTAL
..|...|  .  .  .. .....| |||||||.|||| |||.|.. .|  |||||.||   |..  .|||.|||||.|.. || |||| ... |.|.|  
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

VEGGKTKCEHYWPAGEEPQL--HGNVTVTLVGSNQTDNFIERTLLLEKEGT--ERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQedgaATGPIVV
.|.|| ||. |||  .. .|  .. ..|.|.. .. |.|  |.| ...  .   | |.| .. .| ||||| |.|.|. ....|.  ..     .|||||
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....dagPivv

HCSAGVGRTGTFIAADMLMDAIQRSTatdYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
|||||.||.||.|. |.... |.| .    .||  .. |.||||  .|||  |||. ....| ...
hcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_CG42327_pd Subfamily CG42327 4259-4439 4.5e-33 109.2 In-house 8-193 (319) alignment
Range on Protein: 4259-4439
Range on HMM: 8-193/319.0
SDEYNNLPameKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKD-DHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMT
 .|...||   .  | . .  .  .||.|. |..|   ||| |. ..    . |..|||..  |  .  |||.| .| ..   || .|||.|. .|| .|
aeefrdlP...qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

ALVEGGKTKCEHYWPA---GEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYlAWTDHGVPESTAPLVGLLRQVKVT
 | | |  .| .|.|.   ... .|.|.. ||| | .  |...  |||| .      | .||| |  | . .|| . |.|. .| .|. .
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_PTPN3_pd Subfamily PTPN3 4261-4519 6.8e-74 243.3 In-house 20-277 (280) alignment
Range on Protein: 4261-4519
Range on HMM: 20-277/280.0
EYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGtDYINASYIKDDHGQ----KKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTAL
....|   .. .|..|||...| .|||||.||||| |||.||     |||||.|.. .       ..||||||||..| ..||.||||...|.|||.| |
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl

VEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNqedGAATGPIVVHC
|| |..|| .|||  |. . .|. .|..  ...| ... | |.|...    ||.... |||||.|||||...| .. ....|. .     ... |.||||
verGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr...sgkeePvvvhC

SAGVGRTGTFIAADMLMDAIQRSTATDYIDVagtIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
|||.|||| .|. .. .  |... .   .|.   . ..|.||| ||||  || ..  ..| . ||
saGigrtGvlilletalalieaaepvypldi...vrtmrdqramlvqtasqykfvCeailkvyee

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 4267-4517 1.9e-51 169.7 In-house 18-295 (297) alignment
Range on Protein: 4267-4517
Range on HMM: 18-295/297.0
AMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGV-AGTDYINASYIK--DDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTK
   .. . ..|..     |||||.|| .| |||.|..| ...||||| |.   |.. . ||| .|||| .|.. ||..|.|..  .|||.. | |.|. |
deargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdk

CEHYWPAGEE-PQLHGNVTVTLVGSnQTDNF---IERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPL-----------------VGLLR--------
|  |||  ..  .  |.| |  . |  .|.|   |   | |     .| |.| |.|.| |||||     |                 ..|.         
capywpsvvqerlkagdvvveflss.tsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvfl

QVKvTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATdyiDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
|.. . . .     ...|||||||||.|  . .|.... ...       |||  . ..||||| ||||| |. .|.  ||  .
qle.slraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkrip...dvaailsilreqrarlvqtleqfellydavlkkl

subfamily_PTPN12_pd Subfamily PTPN12 4268-4519 8.3e-79 259.5 In-house 26-279 (290) alignment
Range on Protein: 4268-4519
Range on HMM: 26-279/290.0
MEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKC
.||.   .|... .|  ||||..|||||..||.|.   .. | |||||..||  .|...|||.|||||.|.. || |.|| ... .||.  .|| ||.||
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

EHYWPAGEEPQL-HGNVTVTLVGSNQTD-NFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQedgAATGPIVVHCSAGVGRTG
|.|||   | .| .|...|||   ...| .|. ||| .|.....|.|. ..| || |||||.|. .|. |...|. ...   .   |.||||||||||||
erYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtG

TFIAADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
| || |.  ..... . .. .||   ....|.||| ||||  || .....|..|...
tiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 4271-4517 3.4e-40 132.6 In-house 42-289 (305) alignment
Range on Protein: 4271-4517
Range on HMM: 42-289/305.0
TRAVTAARQA--RNDDKNRYRNILPYDYTRVQLKGVAGTDYINASYIKDD-HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHY
|...  | |.   .  ||||...   | . |.|.  . .||| | |.      .|..|..|||| .||..|| || .|.   |||.   || || || .|
tqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqy

WPA--GEEPQLHGNVTVTLV-GSN--QTDNFIERTLLL-EK-EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKvtnqedGaATGPIVVHCSAGVGR
|||  ||  .|.. . |  | ||.  . |. |. |||      . . .| | |.  | | |||      . ||  ..      | .  |||||||||.||
wpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......g.skvpivvhcsagigr

TGTFIAADMLMDAIQRSTATDyiDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
||| .| . ... |          .   .  .|.|||  .|.  ||...|| .|  .
tgtivaieyilekiaenkpcp..pmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_egg_pd Subfamily egg 4271-4515 6e-31 102.2 In-house 29-268 (307) alignment
Range on Protein: 4271-4515
Range on HMM: 29-268/307.0
TRAVTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGgkTKCEHY
  ..| | .. | .| | . .   |..||.|.   |    |.| | ..| .    ..| .| || || . || ||....   |||.|. .|    .||.|
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPAGE-EPQLH--GNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLvGLLRQVKvtnQedgaATGPIVVHCSAGVGRTGTF
||  | ..     |.. .. .. ... . . |   |   |...   . ..  .  . . .   ||  .||...   .    .. |.||..  || ...|.
wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvyspl.rvlrklr...n....lskpvvvqdilGvskaatl

IAADMLMDAIQRSTATDYIdVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
.|... .  . |   | .. |  ..  .| .| | |..  .|....| || 
vaieiallsllrGpitksl.vlravvflrlrrrlsvesvllylfvyrlvlf

subfamily_eak_pd Subfamily eak 4271-4517 4.4e-20 66.3 In-house 41-305 (332) alignment
Range on Protein: 4271-4517
Range on HMM: 41-305/332.0
TRAVTAARQARNDDKNrYRNILPYDYTRVQLKGV--AGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYW
 .... ...  . ..|   .|.|||.  |.|         ||||| ..  .  .||| |  .  . .  ||.|| |... .||..   || .  | . |.
llsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PAGE-EPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAP--L------VGLLRQVKVTNQ----------EDGAATGP
|    |   .| . |.     . ...  | | |.|      | ||..  ||.  .|       |      || |  . . ..              .  |
pdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfap

iVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYiDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
 .. .. |  |.|.|.  |.|.  |.      |  |   | |....|   | .  |. ...  ||  .
.iiqsarGsaraGvfvvidllirlidnkkknly.svedlilkvkskrihsvlvalqhsfiyeivldyl

subfamily_PTPN1_pd Subfamily PTPN1 4272-4510 1.8e-67 222.1 In-house 22-264 (290) alignment
Range on Protein: 4272-4510
Range on HMM: 22-264/290.0
RAVTAARQARNDDKNRYRNILPYDYTRVQLKGvAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG
  ...|.. .| ..||||.. |||..|..|.  | .|||||| .. .. ...|| ||||||||..|||.||||... ..||.  .|| ...|| .||| |
fptreaklpenrnlnryrdvspydhsrikler.adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

EE-PQLH---GNVTVTLVGSNQTDNFIERTLLLEKE--GTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEdGAATGPIVVHCSAGVGRTGTFI
||  .|     ...|.|.  ....... |.| ||.      |...|. |..|.| ||||| | .. .| .|. .        || |.|||||.||.|||.
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsl.ssdvGpavihcsaGiGrsGtfc

AADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLH
 .| ..  |...  .. .|.  .. ..|..|  |.||  |  . .
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 4272-4510 2.7e-15 50.8 In-house 37-272 (303) alignment
Range on Protein: 4272-4510
Range on HMM: 37-272/303.0
RAVTAARQARNDDKNRYRNILPYDYTRVQLkgvAGTDYINASYIKDDhGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG
  |.  .  .| ||||. ...  |...|.|   . . || |||.. |  .|| | || ||. |   ||.|. |..   .... .  |  |   .  .|  
psvsknqfvknmdknrfvdvicldhskvkl...sdssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

EEPqLHGNVTVTLVGSNQTDNFIER---TLLLEKEGTERTVTH-YQYLAWTDHGVPESTA-PLVGLLRQVKVTNQEDGAATgPIVVHCSAGVGRTGTFIA
..  |. .  .  ||  .  .. .     .|   .|. ..  | ..| ||    .|  ..  .|  . |..   .    .| | |    .|.||.|||  
qdf.lkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfal

ADMLMDAIQRSTATdyIDVAGTIAKIREQRALLVQTLYQYIYLH
 .    ...   |.  .|.   . ..|. |   || | |. ...
fetahlslhseqas..ldlvkclenvrngrlhavqnlsqfsvvy

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4273-4518 3e-71 234.6 In-house 11-265 (270) alignment
Range on Protein: 4273-4518
Range on HMM: 11-265/270.0
AVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIK-DDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYW
  .   .||.   |||..|||   |||.|. .     | |||| |..  |. .|||||..||||.|...|| |.||.....|||.| |.| |..||| ||
esdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYW

PAGEEP---QLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTA------PLVGLLRQVKVTNQEDGAATgPIVVHCSAGVG
||  .      .|...|. . ..... .| . | ||..|.|| ..|..| .| |||||...        |. .||.|. ...|   |. |..||||||||
paepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvg

RTGTFIAADMLMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
||||.|| |. . ......    .||.  |...|..|  |||.  || .|...|.  .|
RtGtlialDiavrlLeetkk...vdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 4273-4513 2.6e-57 188.8 In-house 29-273 (287) alignment
Range on Protein: 4273-4513
Range on HMM: 29-273/287.0
AVTAARQARNDDKNRYRNILPYDYTRVQL--KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPA
   || .  .  |||| ..||.| ||| |  .|  |.||||| |.   . ....||.|||.. |.  || .|.|........||  || .. || .||| 
tfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPe

GEEPQLHGNVTVTLVGS-NQTDNFIERTL-LLEKEGTE-RTVTHYQYLAWTDHGVPESTAPLVGLLRQV--KVTNQEDGAATGPIVVHCSAGVGRTGTFI
 | | . |  .|.|.   ..  ..  |.| |.. |. | | |  ...|.| |.... ..  |. .  .|  ..  . |.. .||.|||...|.||.|...
revPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGill

AADMLMdaiQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
|  .|.   .|   .  .||| .....||.|| |||.  |. .|  ..
atlvlv...srledlGrvdvaavvirlreyraalvqavvqlrllyeal

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 4273-4364 3.1e-07 24.2 In-house 25-118 (332) alignment
Range on Protein: 4273-4364
Range on HMM: 25-118/332.0
AVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGT-DYINASYIKDDHGQKKYIATQGPLPNTIEH-FWEMVWENQTSTIVMMTALVEGGKTKC
  |  .   | | ||   .  .|..||.|    |  |. |||..     .  || .| |. .  |. || || | . | |...  . |  | |.
pntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 4274-4514 1.8e-67 222.9 In-house 17-252 (284) alignment
Range on Protein: 4274-4514
Range on HMM: 17-252/284.0
VTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTalveggKTKCEHYWPA
 | |   .| ||||. .||..| ..|.|.   |. ..||||||.|.    ..|||||||||.||.. || |.|| ..||||..|      | ||  ||| 
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

-GEEPQLHGNVTVTLVgsNQTDNFIERTLLLEKEG---TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDGaATGPIVVHCSAGVGRTGTFIA
 ... . ...| |..|  ....... | . | ..|     |... . .| | |.|||.....|. |...|.  ..       .|||||||||||||..|.
kivikeerfkvkvdsv..eeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsken.hranivvhcsagvgrtgvyiv

ADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
 |.|.| ...    . .||  .. ..|.||  ||| | || ... ..|
ldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysall

0049772 (Phosphotyrosine protein) phosphatases II 4274-4516 3.2e-43 144.0 In-house 38-279 (314) alignment
Range on Protein: 4274-4516
Range on HMM: 38-279/314.0
VTAARQARNDDKNRYRNILPYDyTRVQLKG--VAGTDYINASYIKDDhgqKKYIATQGPLPNTIEHF----------WEMV--WENQTSTIVM-------
...|.. .| ||||| .|||.| .||.|.|  | |.|||||||..     .|.|||||||..|.. |          |.||  ..... .|||       
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------MTALVEGGktkceHYWPAGEEPQLHgnvtvtlvgsnqtdnfierTLLLEKEGTERTVTHYQYLAWTDHGVPeSTAPlvgLLRQVKV
               . | ..|      ...| . ..|.                   . | ..|  ||.. .| .. ..|...| ...    ... ...
delsrLdaAlgKtpllildgng.....neptaadlellk...................eelydpelferlgikylripvpDgsap.lled...fdeflef

TNQEdgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQrstatdyIDVAGTIAKIREQRA-----LLVQTLYQYIYLHRTVLSL
 ..    . ||..|||.||.||||||..|..|| . .       .... ... .|..|       ....| ||.. .. .| .
ieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg.......vsleealedvrlkRpinpnpgfieqleqyefilealley

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 4274-4517 9.4e-38 124.6 In-house 42-282 (301) alignment
Range on Protein: 4274-4517
Range on HMM: 42-282/301.0
VTAARQARNDDKNRYRNILPYDYTRVQLKGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEE
.| .    ..||.|| ..     | |..        | | .|. .   ...|||||||.|| | || |.   .  .|||..  ||  ..|||.| |   .
itesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

PQLH-GNVTVTLVGSN--QTDNFIERTLLLEKE---GTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQedgaatgPIVVHCSAGVGRTGTFIAA
 .|. |  ..... ..    .. ..||| .|      . ||||||||  |||.|||.| | |  |.  || ...       |||||||||.||. .||..
ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigt

DMLMDAIQrstATDYIDVAGTIAKIREQRALLVQTLYQYIYLH-RTVLSLI
..|  ...   |   |... .....||.|   |||  |  ..   ||  ||
eylareve...adptieltealkhlrehrwngvqtnsqlywmtlGtvyrli

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 4274-4421 2.3e-14 47.6 In-house 88-234 (244) alignment
Range on Protein: 4274-4421
Range on HMM: 88-234/244.0
VTAARQARNDDKNRYRNILPYDYTRVQL-KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEggktkCEHYWPAGE
.  | .  |  |||    ||.|. || | ||  |  |||||..       .|| || || .|   || |. |     .|.. .. |      . |||  |
mkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdse

EPQL-HGNVTVTLVGSNQTDNFIERTLLLEKEGTE--RTVTHYQYLAWTDHG
  .    ..||||   ..  |     | .| .  |  ...| .|   |   |
plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 4274-4352 9.5e-11 35.8 In-house 29-115 (347) alignment
Range on Protein: 4274-4352
Range on HMM: 29-115/347.0
VTAARQARNDDKNRYRNILPYDYTRVQLKG--------VAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVM
.|..   .. .||| ..    | ||| |               |||||.|| |  .|.|| || |||.|.  || ||   . . .| 
ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

0040439 (Phosphotyrosine protein) phosphatases II 4276-4517 7.6e-78 256.8 In-house 5-246 (249) alignment
Range on Protein: 4276-4517
Range on HMM: 5-246/249.0
AARQARNDDKNRYRNILPYDYTRVQLKG---VAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgE
 |.   | |||||..|||||..||.|.    . ..||||||||.  . ....||||||||.|.|.||.|.||.. ..|||.| ||| |. ||..|||  .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.g

EPQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgAATGPIVVHCSAGVGRTGTFIAADML
... .|..||||.  .. |... ||| |.  ..|..|||.|.||. | |||||.|...|. ....|.  ..|.    ||..||||||||||||||||...
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylm

MDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
.. ...      .|.  .....|.||   ||.. ||..|.. .| |.
leqlekelg...vdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 4276-4516 2.1e-67 222.0 In-house 3-241 (250) alignment
Range on Protein: 4276-4516
Range on HMM: 3-241/250.0
AARQARNDDKNRYRNILPYDYTRVQLKGVA---GTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTkCEHYWPAgE
 |.. .| .|||| .|...| .|| |. .     .||||||...  ...| .|||||||..|||.|| ||.|....||||.| |.| .|| ...|||. |
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.e

EPQLHGNVTVTLVGSNQTDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEdgAATGPIVVHCSAGVGRTGTFIAADML
... .|.|||.|  ...  ... |.| | |  .  ||.| ......| | |||| .   ..||..|. ..|.  | ..|..|.|||||||.|.||| | .
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq..agnaPvivqCsaGvgrsGafiaidav

MDAIQRSTatdYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
.. ....     .||   | ..|..|   |..| ||..... .|  
lerlkkek...vvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4276-4514 3.3e-51 168.7 In-house 2-238 (239) alignment
Range on Protein: 4276-4514
Range on HMM: 2-238/239.0
AARQARNDDKNRYRNILPYDYTRVQLKGVA---GTDYINASYIKDDHG-QKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG
||..  |  |||| ||. ||..|| |. ..    .|||||||..|  |  | |||||| .  .   || |.|...   |||.| |.|| | || .|||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

EepQLHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRqvKVTNQEDgAATGPIVVHCSAGVGRTGTFIAADM
     . |. |||  ..   ..| ||... . |   || | .|..  | |.|||. .. ..|| |  |.|..     . | |.||||||||||.|.  | 
t..skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr..kitkdsl.pgarpwvihcsagvgrtgaflvida

LMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
..   ..  .   .|.   .  |||.|  .|||  ||...| .||
mlrqakkqkt...vdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4276-4514 4e-51 168.5 In-house 1-237 (239) alignment
Range on Protein: 4276-4514
Range on HMM: 1-237/239.0
AARQARNDDKNRYRNILPYDYTRVQLKGVA---GTDYINASYIKDDHG-QKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG
||..  |  |||| ||. ||..|| |. ..    .|||||||..|  |  | |||||| .  .   || |.|...   |||.| |.|| | || .|||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

EepQLHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRqvKVTNQEDgAATGPIVVHCSAGVGRTGTFIAADM
     . |. |||  ..   ..| ||... . |   || | .|..  | |.|||. .. ..|| |  |.|..     . | |.||||||||||.|.  | 
t..skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr..kitkdsl.pgarpwvihcsagvgrtgaflvida

LMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
..   ..  .   .|.   .  |||.|  .|||  ||...| .||
mlrqakkqkt...vdifnyvkairedrphmvqtseqyvfihlavl

0042113 (Phosphotyrosine protein) phosphatases II 4277-4517 4e-76 250.9 In-house 4-243 (245) alignment
Range on Protein: 4277-4517
Range on HMM: 4-243/245.0
ARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEE
|.   | |||||..|||||.|||.|. . |   .|||||||.. ..  .|.||||||||.|.|.||.|.||.. .||||.| ..| |. ||..|||  .|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

PQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEdgAATGPIVVHCSAGVGRTGTFIAADMLM
.. .|..||||.. .. |... ||| ..  ... .|.|.||.|| | |||||.... |. .|. |.   .|   . ||..||||||||||||||||....
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylml

DAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
. ...      ...  .....|.||   |||. ||..|.. .| |.
eqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallell

0037934 (Phosphotyrosine protein) phosphatases II 4277-4516 3.6e-74 244.7 In-house 5-241 (243) alignment
Range on Protein: 4277-4516
Range on HMM: 5-241/243.0
ARQARNDDKNRYRNILPYDYTRVQLKGvagTDYINASYIKDDhgqKKYIATQGPLPNTIEH----FWEMVWENQTSTIVMMTALVEGGKTKCEHYWPagE
|.   | .||||..|||||..|| |.|   .|||||..|.     ...||||||||.|.|.    ||.|.||.....|||.| ||| |. ||..|||  .
allpenlsknrysdilpydhsrvkleg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..g

-EpqLHGNVTVTLVGSNQTDNFIERTLLLEK---EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQE-----DGAATGPIVVHCSAGVGRTGT
 .   .|..||||......|... ||||||    .. .|.|.||.||.| |||||.|...|. .|..|.   .|          ||..||||||||||||
ev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

FIAADMLMDAIqrstatDyIDVAGTIAKIREQRAL-LVQTLYQYIYLHRTVLSL
.|||..... .      . .|.  .....||||    |||. ||..|.. .| |
liaaylmllll......g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 4278-4513 8.1e-33 108.6 In-house 31-266 (285) alignment
Range on Protein: 4278-4513
Range on HMM: 31-266/285.0
RQARNDDKNRYRNILPYDYTRVQLKGVaGTDYINASYIKD-DHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG-EEPQ
    | | ||| ..   . ||| ||     ||| ||...   . |  ||.||||||.|.  || |..... . ..|. .|.|||  ||  |.|    |  
ayeanpdlnryadvrcieetrvvlknh.drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

LHGNVTVTLVGSNQ--TDNFIERTLLL-EKE--GTE-RTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaatGPIVVHCSAGVGRTGTFIAADM
  |.  .||   ..      |  .| . . |   .|   . | |   | |.  || . |.. | . ||  | ..     ||.|||||||||| ||.  | 
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke....kpicvhcsagvgrtatfvgidy

LMDAIQRSTATDYIDVagtIAKIREQRALLVQTLYQYIYLHRTV
    |      . .|.   . ..|  |   ||.  |...|.  .
atirimenpniemldi...vremramrfqavqshmqflflyvvl

subfamily_ptpA1_pd Subfamily ptpA1 4279-4474 6.8e-47 155.1 In-house 44-256 (418) alignment
Range on Protein: 4279-4474
Range on HMM: 44-256/418.0
QARNDDKNRYRNILPYDYTRVQLKGV---AGTDYINASYIkDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPA---GE
. .|  |||| |||| ..|||||| .    |.||||| || |    |..|.|||||||||  || |||||.   |||..   |  . ||..|||    ||
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi.dgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

EPQLHGN-------VTVTLVGSNQT--DNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKV-TNQE--DGAATGPIVVHCSAGVGR
.  ..||        .| ||   |    . | | . |  ||  | .|.|||  | || .|. | |.  ||. .    ||         ||.|||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGTFIAADMLMDAI
|||| .| ..|  .
tgtfctavimmkkl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 4281-4514 3.8e-60 198.1 In-house 2-236 (237) alignment
Range on Protein: 4281-4514
Range on HMM: 2-236/237.0
RNDDKNRYRNILPYDYTRVQLKGVA-GTDYINASYIKDDHG-QKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHG
.|  |||| ||  ||..|| |||   |.|||||.|.|.  |  |||||.|||| .. . ||.|||... | |||.| |.|| . || .|||  ..|. .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

NVTVTLVGSNQTDNFIERTLLLEKEGTERT---VTHYQYLAWTDHGVPESTAPLVGLlRQVKVTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDaiq
 .||.|   ..  ..  |.||| |..| .    .  ||. .| |.|||. || |. . |.  . . .  . .|| ..|||||||||| |.  | ..    
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrf.rkniinrsphvsesgpwiihcsagvgrtgiflvidamlr...

RSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
..     .|.   .  | |.|  ..||  ||...|.|.|
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 4281-4517 1.5e-32 107.6 In-house 42-276 (312) alignment
Range on Protein: 4281-4517
Range on HMM: 42-276/312.0
RNDDKNRYRNILPYDYTRVQLKGVAgTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPA------GEEP
.  | ||| ||  .|  |  | |     || | ..|     .....||||| ||. |||...    ...|......|| |  || .|          |. 
kfkdlnrypniqcwdrgrftlagde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

QLHG-NVTVTLVGSNQTDNFIERTL--LLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQedgaatgPIVVHCSAGVGRTGTFIAADMLM
...   .|   .| .  |.   | |  ..   | |  . |||. .| |||.|.|      ||  ||  ..       |.. |||||||||||..  . ..
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.......pviahcsagvgrtgtlaliesmi

DAIQRSTATdyiDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
 |..        .|  .   .| .||  |... ||.|  |.|| ..
aalrhprkq...nvkdsfvllrkdrarsvrvfpqyvyalrcvlefl

Y_phosphatase Protein-tyrosine phosphatase 4282-4514 8.8e-80 262.9 Pfam-A 1-234 (235) alignment
Range on Protein: 4282-4514
Range on HMM: 1-234/235.0
NDDKNRYRNILPYDYTRVQLKGVAG-TDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWP-AGEEPQLHGN
| .||||..||||| |||.|||  | .|||||.|.|  . .||.|||||||..|||.||.|||......|||.| |.| |..||..||| . ||.. .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VTVTLV-GSN-QTDNFIERTLLLEKEGTER---TVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNqedGAATGPIVVHCSAGVGRTGTFIAADMLMDAI
..|.|.  .. ...... |.| |.|...|.   .|....| .|.|||||||. .|. |.|.|. ..    | .||.||||||||||||||.|.|.|.. .
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

QRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
..      .||  .. ..|.||. .||.| |||.|....|
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 4282-4514 8.8e-80 262.9 In-house 1-234 (235) alignment
Range on Protein: 4282-4514
Range on HMM: 1-234/235.0
NDDKNRYRNILPYDYTRVQLKGVAG-TDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWP-AGEEPQLHGN
| .||||..||||| |||.|||  | .|||||.|.|  . .||.|||||||..|||.||.|||......|||.| |.| |..||..||| . ||.. .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VTVTLV-GSN-QTDNFIERTLLLEKEGTER---TVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNqedGAATGPIVVHCSAGVGRTGTFIAADMLMDAI
..|.|.  .. ...... |.| |.|...|.   .|....| .|.|||||||. .|. |.|.|. ..    | .||.||||||||||||||.|.|.|.. .
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

QRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
..      .||  .. ..|.||. .||.| |||.|....|
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail

0041856 (Phosphotyrosine protein) phosphatases II 4282-4516 3.1e-49 162.4 In-house 1-170 (182) alignment
Range on Protein: 4282-4516
Range on HMM: 1-170/182.0
NDDKNRYRNILPYDYTRvqlkgvaGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTalveggktkCEHYWPageepqlhgnvt
| |||||..|||||..|       . |||||...  .. ....|||||||..|...|..|..|.. .|||..|         .|.|||            
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp............

vtlvgsnqtdnfiertlllekEGTERTVTHYQYLAWTDHGVPEsTAPLVGLLRQVKVtnqedgaATGPIVVHCSAGVGRTGTFIAADMLMDAiqrstatd
                     |  ||....|.|| | |||||. .  |. ....|.          ||..||||||||||||..||....          
.....................ellerlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl........

YIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
 ...  ... .|..|   |.|. ||..|.. .| |
gvsleeavklvrsrRpgmvitpnqyfflqlallel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4284-4380 1.2e-25 85.0 In-house 49-162 (350) alignment
Range on Protein: 4284-4380
Range on HMM: 49-162/350.0
DKNRYRNILPYDYTRVQLK-----------GVAGTDYINASYIKDD------HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEH
 ||||.|||||. .||.||            . . |||||.|.|          . ||||||.|||.|.. |.... .|.   |...|..|| .  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPAGEEPQLHGNV
||. |.  . .  .
YWqegsydditvkl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4284-4372 1.7e-13 44.7 In-house 50-157 (349) alignment
Range on Protein: 4284-4372
Range on HMM: 50-157/349.0
DKNRYRNILPYDYTRVQLKG-----------------VAGTDYINASYIKDD--HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKC
 ||||..||||...||.||                      ||||| |.|      .||||||| ||| |.. |....  |.   .. ..   | .  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

EHYWPAGE
. ||  ..
diywqels

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 4286-4514 4.6e-26 86.6 In-house 23-256 (290) alignment
Range on Protein: 4286-4514
Range on HMM: 23-256/290.0
NRYRNILpYDYTRVQLKGVA---GTDYINASYIKDDHGQkKYIATQGPLPNT-------IEHFWEMVWENQTSTIVMMTALVEGGKT----KCEHYWPAG
.|... |    ||| |||       ||| |....  .|. . |.|| |. ..       ||.|| |. . .   .||.    |  .      |..| |  
qRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

EEPQLH-GNVTVTLVGSNQTDNFIERTLLLEKE-GTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKvTNqedgaaTGPIVVHCSAGVGRTGTFIAADM
.. .|  ...||      . |....|.|... . . | ||||...  |..  |.|.|  |. |...|| ..      . |..|||  |. |  .. | ..
vgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as......ktpvivHcvdGiSrsAalaaiil

LMDAIQRStaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
 .  |  .  .. . ..  . ..|.||||....  .. .    ..
gyQkiaet..sgsvkledvlkalrkqralaitsalelafvdagiv

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 4292-4421 4.8e-10 33.9 In-house 3-125 (130) alignment
Range on Protein: 4292-4421
Range on HMM: 3-125/130.0
LPYDYTRVQlkgvaGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEggktkCEHYWPAGEEPQ-LHGNVTVTLVGSNQT
|.....|.|     | .|||||..      ..|. || || .|  .|| |. |     .|.. .. |      . |||  |  .    ...|||   .. 
lefevsrlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrdef

DNFIERTLLLEKEGTE--RTVTHYQYLAWTDHG
.|     |  |..  |  ...| .|   |   |
knikasnleiesdlneshqaltmfqisnwpsdg

0044763 (Phosphotyrosine protein) phosphatases II 4298-4515 3.6e-33 110.1 In-house 6-169 (178) alignment
Range on Protein: 4298-4515
Range on HMM: 6-169/178.0
RVQL---KGVAGTDYINASYIKDDhgqkKYIATQGPlpntiEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEpqlhgnvtvtlvgsnqtdnfi
|| |    |. ..||||||.| ..     |.....|     ....|...|.  ..||..|  .|.|. || .||| ...                     
rvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.....................

ertlllekegtertvTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDGaatGPIVVHCSAGVGRTGTFIAADMLMDAiqrstatdYIDVAGTIAKIRE
                .|... . |||||.... .  ... ..   .|.|   ||..|||||||||.||..||....           ...   |. .||
...............iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaielvre

QRAlLVQTLYQYIYLHRTVLS
.|   |..  |. .|..  | 
rRp.ivpnpgqlrqLyefelr

0036282 (Phosphotyrosine protein) phosphatases II 4306-4510 4.4e-44 145.6 In-house 1-163 (174) alignment
Range on Protein: 4306-4510
Range on HMM: 1-163/174.0
GTDYINASYIKDDHGQKKYIATQGPLPntiehFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgeepqlhgnvtvtlvgsnqtdnfiertlllEKEGT
|.||||||...  .  ...||.||||.     ||||..|.. .|.||.. ..| |..|| .|||                                .|  
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

ERTVTHYQYLAWTDHGVPESTApLVGLLRQVKVTNQEdgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQrstaTDYIDVAGTIAKIREQRALLVQTLYQ
||.. .|.|| | |||||...  |  ....|.   .|     ||..||||||||||||..||....  .     ....|.  .....| ||   |||  |
erlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQ

YIYLH
|..|.
yrfly

0043147 (Phosphotyrosine protein) phosphatases II 4306-4510 4.6e-42 139.0 In-house 4-154 (172) alignment
Range on Protein: 4306-4510
Range on HMM: 4-154/172.0
GTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALveggktkcehywpageepqlhgnvtvtlvgsnqtdnfiertlLLEKEGT
|.|||||||..  .  ...|||||||.||...||.|..|.. ..||..| |                                          |. .|. 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpell

ERTVTHYQYLAWTDHGVPeSTAPLVGLLRQVKVTNQED-GaatGPIVVHCSAGVGRTGTFIAADMLMdaiqrstatDYIDVAGTIAKIREQRALLVQTLY
||.. .|.|| | ||||| ... |  .|....   ... |   ||..||||||||||||..||....           ...  ..| .||.|   ||.  
erlgiqylylpwpDhgvp.llellleflefidellalspg...gpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnps

QYIYLH
||..|.
qyrfly

0046846 (Phosphotyrosine protein) phosphatases II 4306-4516 2e-41 137.0 In-house 11-172 (176) alignment
Range on Protein: 4306-4516
Range on HMM: 11-172/176.0
GTDYINASYIKDDhgqkKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLhgnvtvtlvgsnqtdnfiertlllekegt
. |||||..|  .    ..||||||||.|...|.||..|.. ...|..| .|| |. || .|||  |....                             
dldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

ertvtHYQYLAWTDHGVPEStAPLVGLLRQVKVTNQEDgaatGPIVVHCSAGVGRTGTFIAADMLMDaiqrstaTDYIDVAGTIAKIREQRA-LLVQTLY
     .|..| | |||||.. . |  ||....   .|.    ||..||||||.|||||..||..|.           ..|  ..|..||||    |||  
.....qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllel.......ekglsveealalvreqRplgavqtpe

QYIYLHRTVLSL
|| .|.. .| |
Qyrflyefelll

0051429 (Phosphotyrosine protein) phosphatases II 4307-4517 9.4e-48 158.5 In-house 4-225 (272) alignment
Range on Protein: 4307-4517
Range on HMM: 4-225/272.0
TDYINASYIKDDHG---QKKYIATQGPLPNTIEHFWEMvWENQTSTIVMMTALVEGGKTKCEHYWP-----------AGEEPQLHGNVTVTLVGSNQTDN
..||||....  ..    .......||||.|...|| . .|.. .|||... ..| |. ||. |||            .... |.|...|||.   ....
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FIERTLLLE---KEGTERTVTHYQYLAWTDHGVPESTapLVGLLRQVKVtnqedgaaTGPIVVHCSAGVGRTGTFIAADMLMdaiQRSTATDYID-----
.| |.|||.   . |. |.|.|..|..| |||||...  |. ||...           ||..||||||..||||..|...|.   .. .... .|     
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvalllll...lgvsletivddYllt

---VAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
   ........|.||.  |||  ||..|.. .| |.
nlyleeaveelraqrpgavqteeqylflyeallell

0051082 (Phosphotyrosine protein) phosphatases II 4307-4512 1.1e-31 104.8 In-house 3-148 (151) alignment
Range on Protein: 4307-4512
Range on HMM: 3-148/151.0
TDYINASYIKDDhgqkkYIATQGPLPntieHFWEMVWENQTSTIVMMTALVEGGktKCEHYWPAGEepqlhgnvtvtlvgsnqtdnfiertlllekegte
.||||.||. .      .....|||.    .|.|...|.. .|||... ..| |  .| .|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

RTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVtnqedgAATGPIVVHCSAGVGRTGTFIAADMLMdaIQrstatdyIDVAGTIAKIREQRALLVQTLYQY
..|.|...| |.|.|.|.|.. .. .|...           ||..||||||.|||||..|.....   .       .... ... .|..|  .||.  |.
ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleealeeyrlkrpgvvqpnqqf

IYLHRT
..... 
lfqlfa

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 4318-4510 1.5e-16 54.7 In-house 85-281 (302) alignment
Range on Protein: 4318-4510
Range on HMM: 85-281/302.0
DHGQKKYIATQ--GPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQL-HGNVTVTLVGSN-QTDNFIERT----------LLLEKE
   .|. .. .   |  .|.| .| .. . ... .| ....||... || .|.    . .|  |. ||. |  . . ..| ..               |.
Gtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk

GTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEdgaatgpIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYIDVagtIAKIREQRALLVQTL
 ...||   .. || ||| |. . . . .|.  .   ..       ..||||||||||||..|    ..  ..   || ...   .  .|. |   ||. 
kvkktvdilafsawpdhGapkeaytaldilkfcesykkn.......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsi...vlpvrqcryGavqde

YQYIYLH
 | ||| 
qqliyll

0049260 (Phosphotyrosine protein) phosphatases II 4319-4510 2.3e-39 129.9 In-house 6-143 (152) alignment
Range on Protein: 4319-4510
Range on HMM: 6-143/152.0
HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWpageepqlhgnvtvtlvgsnqtdnfiertlllekegtertvtHYQYLAWT
. ....||||||.|||...||.|..|.. .||||.| |.| || |||.|.                                          .|..| | 
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwp

DHGVPESTAPLVGLLRQVKVTNQEDGaatGPIVVHCSAGVGRTGTFIAADMLMdaiqrstatDYIDVAGTIAKIREQRALLVQTLYQYIYLH
|||||...  |  ||. ..  ....|   ||..||||||||||||..||....           ...  ..| .||.|   |..  |...|.
Dhgvpdlsqlllflllfieklaldkg...gpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 4319-4509 1.5e-23 78.0 In-house 2-196 (199) alignment
Range on Protein: 4319-4509
Range on HMM: 2-196/199.0
HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEP-QLHGNVTVTLVGSNQTDNFIERTLLLEKEGT----ERTVTHYQ
.||..||||| || .|.  ||.||||  .  |||.       ..    |||. |     .|...||        ..   .|.| .. |     | ..|||
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YLAWTDHGVPEsTAPLVGLLR-QVKVTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStATDYIDVAGTIAKIREQRALLVQTLYQYIYL
. .| ..  |.  | .||..    .|... .     |..|||| | | || |.| |. . . . |  |  .|.     ..|. |  .. .| .| ..
ftswkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 4320-4509 2.1e-23 77.5 In-house 2-195 (198) alignment
Range on Protein: 4320-4509
Range on HMM: 2-195/198.0
GQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEP-QLHGNVTVTLVGSNQTDNFIERTLLLEKEGT----ERTVTHYQY
||..||||| || .|.  ||.||||  .  |||.       ..    |||. |     .|...||        ..   .|.| .. |     | ..|||.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

LAWTDHGVPEsTAPLVGLLR-QVKVTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStATDYIDVAGTIAKIREQRALLVQTLYQYIYL
 .| ..  |.  | .||..    .|... .     |..|||| | | || |.| |. . . . |  |  .|.     ..|. |  .. .| .| ..
tswkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 4322-4401 9e-09 29.1 In-house 236-312 (440) alignment
Range on Protein: 4322-4401
Range on HMM: 236-312/440.0
KKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEggKTkCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLE
. .|||| ||  |.  || .| . . |||.|.  | .  || |  |||        |  ||   ||.. .    ||| | 
nafiatqmpldstvldfwrlvhdyristiimlnqlnd..kt.csiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 4326-4516 1.2e-23 78.6 In-house 39-220 (255) alignment
Range on Protein: 4326-4516
Range on HMM: 39-220/255.0
AtqgplpnTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGE-EPQLHGNVTVTLVGsnQTDNFIERTLL----LEKEGTERTVTHYQYLAWTDH
        |...|....  ..|...||.. . | |. ||..|.|    | .   .|.||      . . . |||     | .    .||.||.|  | ..
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiek

GVPESTAPLVGLLRQVKVTNqedgaatgPIVVHCSAGVGRTGTFIAADMLMDAIQ---RSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
  || .  .  .|. |. .         ..|||||.|.||. .|. |...   .    . | |  .|    . ..|..|.  ..|  |  .   .|| |
naPelareilnilkvvrdsk........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

subfamily_hpo-7_pd Subfamily hpo-7 4326-4517 1.2e-20 68.5 In-house 42-227 (263) alignment
Range on Protein: 4326-4517
Range on HMM: 42-227/263.0
AtqgpLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGE-EPQLHGNVTVTLVGSNQtdNFIERTL----LLEKEGTERTVTHYQYLAWTDH
     | .||. |....  ..|...||..   | |. ||..|.|    | |   ||.|.   . .  . . .||     |..  . .||.||.|  | ..
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiek

GVPESTAPLVGLLRQVKVTnQedgaatgPIVVHCSAGVGRTGTFIAADMLMDAIQ---RSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
  || .   . .|. ..   .       ..|||||.|.||.  |  |...   .    . | |  .|    . ..|..|.  ..|  |  .   .|| ..
ndpelareilnilkvarns.k.......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv





subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4388-4514 1.2e-14 48.8 In-house 210-341 (350) alignment
Range on Protein: 4388-4514
Range on HMM: 210-341/350.0
NQTDNFIertlllekegtertVTHYQYLAWTDHG---VPESTAPLVG----LLRQVKVTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMD------A-
  .| ..              | . |.  | | .    |||  . .     |. .    .  | | . ||.||||||||||||... |.|.         
aasdPyv..............vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenl

IQRSTATDYI----D-VAGTIAKIREQRALLVQTLYQYIYLHRTVL
 ..|.  |.     | .  .. ..|.||  .||.| |.|... ..|
tkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

0048076 (Phosphotyrosine protein) phosphatases II 4397-4514 4.5e-24 80.2 In-house 35-140 (145) alignment
Range on Protein: 4397-4514
Range on HMM: 35-140/145.0
TLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaatGPIVVHCSAGVGRTGTFIAADMLMDaiqrstatDYIDVAGTIAKIREQR
.|  |.|. ||....|.|| | |||||.... |  .|....   .|.    ||..||||||||||||..||....           ...  .....|.||
nltselellerlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsqr

ALLVQTLYQYIYLHRTVL
   |..  |...|.. .|
pgavpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 4401-4511 2e-22 74.9 In-house 41-139 (144) alignment
Range on Protein: 4401-4511
Range on HMM: 41-139/144.0
EKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaatGPIVVHCSAGVGRTGTFIAADMLMdaiqrstaTDYIDVAGTIAKIREQRALLV
|.|  ||....|..| | |||||.... |  .|. ..   .|.    ||..||||||||||||..||....        .  ...  ..| .|..|   |
epefleregiqylhlpwpDhgvpdllellleflefieealeeg....gpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrsrrpgav

QTLYQYIYLHR
..  |...|..
pnpgqlrfLle

0038934 (Phosphotyrosine protein) phosphatases II 4402-4471 1.3e-09 33.4 In-house 72-139 (194) alignment
Range on Protein: 4402-4471
Range on HMM: 72-139/194.0
KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaATGPIVVHCSAGVGRTGTFIAADMLM
.|  |.   .|  | . |.|.. |.. |   |. |.. ..||  . | ..||| ||.|||||..|| ...
peefekagieylklpfpddgtvPsleillrfldlvdeflned..pggvvaVHCkaGlgRtGtlvaaYLiy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 4406-4515 2.1e-19 64.2 In-house 88-192 (440) alignment
Range on Protein: 4406-4515
Range on HMM: 88-192/440.0
ERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTnqEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQ
 ||. .|.| .| |.|||. ..|.. ....|. .  .. |. ||..||||||.||||  || | ..   .||   | ||.   |  .|..|  .|||  |
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes..qekagngpllvhcsagagrtgviiavdsilreakrs...dqidifsfinsmrnnrpqmvqtpeq

YIYLHRTVLS
| ..| .|| 
yafvheavle

subfamily_PTPDC1_pd Subfamily PTPDC1 4406-4507 4.6e-09 31.0 In-house 80-166 (182) alignment
Range on Protein: 4406-4507
Range on HMM: 80-166/182.0
ERTVTHYQYlAWTDHGVPestaPLVGLLRQVKVTNQedGAATGPIVVHCSAGVGRTGTFIAADMLMDaiQRSTAtdyidvAGTIAKIREQRALLVQTLYQ
|. ...|.. .|.|.||.    .|  .|  ||| ..      | . ||| || ||||  ||. ..    .| ||      . .| ..|..|.  .||  |
eqgiyvynf.gwkDygva....sleriLdivkvvaf..alqegkvavhChaGlGrtGvliacylvya..krlta......ekaiklvrskrpksiqtreq

YI
  
ve

PTPc_DSPc_SM00012 4408-4514 7.5e-33 108.2 In-house 1-104 (105) alignment
Range on Protein: 4408-4514
Range on HMM: 1-104/105.0
TVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDGAaTGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTatDYIDVAGTIAKIREQRALLVQTLYQYI
||.||.|..|.||||||.. ... |||.||  ... .  ..|.||||||||||||||.|.|.|.. ....|  . .|.  .. ..|.||. .|||..||.
tvkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqyl

YLHRTVL
.|.| .|
flyrall

PTEN_1 4414-4482 1.6e-06 23.0 In-house 99-163 (196) alignment
Range on Protein: 4414-4482
Range on HMM: 99-163/196.0
YLAWTDHGVPestaPLVGLLRQVKVTNQEDGA--ATGPIVVHCSAGVGRTGTFIAAdMLMDAIQrSTATDY
 . ..|||.|    .|  |.. .|.  .   .    . ..||| ||.||.|| .||  || . . .|| . 
hfpieDhgap....slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa.yLmykgk.ltadeA

subfamily_CDC14_pd Subfamily CDC14 4436-4472 1.8e-06 22.0 In-house 256-288 (328) alignment
Range on Protein: 4436-4472
Range on HMM: 256-288/328.0
VKVTNQEdgaaTGPIVVHCSAGVGRTGTFIAADMLMD
......     .| |.||| ||.|||||.||. .. .
leiaeka....eGaiavhCkaGLGrtGtLiacylmkh

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4439-4515 6.3e-08 26.3 In-house 257-342 (349) alignment
Range on Protein: 4439-4515
Range on HMM: 257-342/349.0
TNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQ----RSTATDYID-----VAGTIAKIREQRALLVQTLYQYIYLHRTVLS
 .  | . . ...|||||| ||||...  |.|.. ..     |   ..       .  .. ..| ||  .|| | |.| .. ..| 
rlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

subfamily_CG42327_pd Subfamily CG42327 4446-4513 4.3e-15 50.2 In-house 246-311 (319) alignment
Range on Protein: 4446-4513
Range on HMM: 246-311/319.0
ATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
  ||.||||| ||||||. ||.|. .  .. |  .  .|.  ..  .|..||  |.|  || ......
sqGPlvvhcsdGvGrtGlviasdiairsleeskrs..vdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 4450-4513 8.6e-09 29.7 In-house 1-61 (69) alignment
Range on Protein: 4450-4513
Range on HMM: 1-61/69.0
IVVHCSAGVGRTGTFIAADMLMDaiqRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
.|||||.| ||||||||  . |    |  .   .|.   .  .|  | ..|    .||..| ..
mvvhcssgtgrtgtfiaimvema...rikseklvdifnnvqymrkcrpmmvmneieyifihdal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 4451-4513 4.6e-08 27.3 In-house 1-60 (69) alignment
Range on Protein: 4451-4513
Range on HMM: 1-60/69.0
VVHCSAGVGRTGTFIAADMLMdaiQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
|||||.| ||||||||  . |    |  .   .|.   .  .|  | ..|    .|...| ..
vvhcssGtGrtGtfiaimvem...arikseklvdifnnvqymrkcrpmmvmneneymfihdal