Gene SpurPTPRB-like-4 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTPRB-like
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP114_AA protein Get Run
SpurP114_AA_4240-4517 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 340-408 2.8e-07 23.8 Pfam-A 14-79 (85) alignment 
Range on Protein: 340-408
Range on HMM: 14-79/85.0
NTGQVTWDIP---ESEYDFFEVTYSPDHGFTnspapiyrMDINENQTRV--EFSFIGILPDTNYNVTVVTVVGA
.. ...|. |   ..... .||.|... |           . . . .|   .. . |. |.|.|...| .| ||
tsltlsWsppkdgggpitgYeveyrekggge........ewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 513-592 1.2e-07 24.9 Pfam-A 2-81 (85) alignment 
Range on Protein: 513-592
Range on HMM: 2-81/85.0
PPVNIETADSQLTSLLIAWSDPG-NETMFDRYYVAYERADELGnfTEVGYLYPNVT-SIFLEGLTPRTEYLFNVSTVVGEGK
.| |.   . . ||| . || |  ..  ...| | |. ... .   .. .  |. | |  |.||.| ||| |.| .| |.|.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngage
fn3 Fibronectin type III domain 899-970 1.9e-06 21.1 Pfam-A 2-76 (85) alignment 
Range on Protein: 899-970
Range on HMM: 2-76/85.0
SVSNVFLTSLDEITLIASWDPP---DVVTSSNEILLtLSTNSTE-VRSVNVSGNVTEFVFKCLEPETEYTVELVSL
...|. ...  . .|  ||.||   .   .. |. .  .....|  ....|... |..... |.| |||.... ..
aPenlsvsevtstsltlsWsppkdgggpitgYevey.rekgggeewkeftvprtttsvtltgLkpgteYefrVqav
fn3 Fibronectin type III domain 1088-1165 1.6e-08 27.8 Pfam-A 1-83 (85) alignment 
Range on Protein: 1088-1165
Range on HMM: 1-83/85.0
SPPSSVTITAVSSRLIEIRWTPPP----NIAEMVLEYFDTESPSNTWEARIDNDG-MYDIHGLDADTSYTVRLSSVGRTGAGD
|.|. .....|.|. ....|.||.    .|    .|| ...... . | .....   . ..|| ..|.|..|. .| . | | 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 1272-1347 1.4e-09 31.1 Pfam-A 1-79 (85) alignment 
Range on Protein: 1272-1347
Range on HMM: 1-79/85.0
SPPESLRVVDETITTLRIEWDSPA--SGLYRGFEVDISPPTALQ-ELPRIVGSDIRGFTFVGLMHNSEYTVSVTTIMGE
|.|| |.| . | |.|...|. |.  .| . |.||. .. .  . .  . | .. . .|. ||  ..||...|... |.
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 1437-1512 8.9e-10 31.8 Pfam-A 4-80 (85) alignment 
Range on Protein: 1437-1512
Range on HMM: 4-80/85.0
DGLELESVGP--YSLDWKVDTsLNDLNYERLEVSYSPESSQT-DSPFDISRCTDgTFTLEGLQPDTEYSVSVTAISGDT
 .| ...|..   .| |.  .  .. .... || |......  .  |...| |. ..||.||.|.|||...|.|..|..
enlsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngag
fn3 Fibronectin type III domain 1530-1604 1.4e-07 24.7 Pfam-A 5-84 (85) alignment 
Range on Protein: 1530-1604
Range on HMM: 5-84/85.0
QLHVVSLSSDEIALAWGPV----NNIQGYAVRLFNAIGIN-MRTLSLSANSMSATLDSLSPASNYSVQLIVMDTDGSRQT
.|.| . .|... | | |      .|.|| |.. .. | .  .. .......|.||  | | ..|....   ...|  ..
nlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 1615-1687 2e-09 30.6 Pfam-A 2-76 (85) alignment 
Range on Protein: 1615-1687
Range on HMM: 2-76/85.0
PPGPITLQSSTQTRLSFTWTPA---TSNFDSYELSISGGDMPEprpVGVVYPNEGNE--FEVGGLLPDTTYNVRIYSV
.|. ... . | | |...|.|     .....||.  .  . .|   . . . .....  ... || |.|.|..|...|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqav
fn3 Fibronectin type III domain 1711-1775 3e-07 23.7 Pfam-A 10-80 (85) alignment 
Range on Protein: 1711-1775
Range on HMM: 10-80/85.0
VGSNQNLTVSWQVQ----EGAESYRLIYTTTNRN--TNSIARPATSTSITIDNLLFGAIYNFRLATIAADG
  .. .||.||.      .  ..|.. | ... .  .... .|.|.|| |. .|  |. |.||.... ..|
evtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag
fn3 Fibronectin type III domain 1907-1973 5.5e-06 19.6 Pfam-A 6-78 (85) alignment 
Range on Protein: 1907-1973
Range on HMM: 6-78/85.0
VEISKVGTNSLEIIWKTD-----NVDEYLLHYSGPDGP--LMSDIVPYIEInYYTFGELTPGTQYSISVISLIN
. .| |...||.. |.       ... | ..|.  .|.    .  ||  .   .|. .|.|||.|...| .. .
lsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavng
fn3 Fibronectin type III domain 1991-2064 1.9e-06 21.1 Pfam-A 2-81 (85) alignment 
Range on Protein: 1991-2064
Range on HMM: 2-81/85.0
PISNLVLTP-QENTINLTWTSP---STMYDGFLICWYSATTEDNKAWLDGDATTYPWVIS--TPNEEYVVSVATFVGDRE
...|| ... ......|.|. |   .  ..|. . . ...... . . . ..||.  ...  .|. ||...|..  |. |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngage
fn3 Fibronectin type III domain 2085-2156 7.3e-07 22.4 Pfam-A 6-73 (85) alignment 
Range on Protein: 2085-2156
Range on HMM: 6-73/85.0
LILKDIATDTISVSWVTIP----GVVDYTLSYSPPDGNE-QATQDIDESsaiaeglnnIYYVNFTGLTPGREYTFTV
| .... ......||   .     .. |.. |.. .|.|   .......          . |..|||.||.||.|.|
lsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprt.........ttsvtltgLkpgteYefrV
fn3 Fibronectin type III domain 2268-2345 7.4e-11 35.2 Pfam-A 2-80 (85) alignment 
Range on Protein: 2268-2345
Range on HMM: 2-80/85.0
PVNNVTLDDSTIFTLTISWENP--IDGSFNMFLVEYAPVRSPDsvmA----LDPINmgTNTAIIPNLQPGTLYNIMVYALAGEE
.. |..... |  .||.||. |   .| .  . |||.......   .      | .  |.......|.||| |.. |.|. |. 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprt..ttsvtltgLkpgteYefrVqavngag
fn3 Fibronectin type III domain 2363-2430 6.9e-06 19.3 Pfam-A 5-73 (85) alignment 
Range on Protein: 2363-2430
Range on HMM: 5-73/85.0
ELRLQTRTSTSISVSWGNTT--RPEVTGFVLRItfQEGDAIDSIKNVSLGDVL-GVEFSDLIPGTNYTVYL
 |..  .||||...||   .  . ..||. ..   .| .  .  |....      |....| |||.|.. .
nlsvsevtstsltlsWsppkdgggpitgYevey..rekgggeewkeftvprtttsvtltgLkpgteYefrV
fn3 Fibronectin type III domain 2638-2713 3.3e-06 20.3 Pfam-A 11-83 (85) alignment 
Range on Protein: 2638-2713
Range on HMM: 11-83/85.0
RRPTSFTIQITLPRRGRYRFLRLRVRRRSQGLDAgpDGDEFLIPTDACpEYTFNNLLPDTDYAVDVNTVAEDGRTE
...||.|.. . |. |.  . . .|. |..|     .  || .| ..  ..|...| |.|.| . | .| ..|  .
vtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprttt.svtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 2730-2804 4.1e-08 26.4 Pfam-A 5-78 (85) alignment 
Range on Protein: 2730-2804
Range on HMM: 5-78/85.0
DISFNEVTTTSISFAWGMVSaDTNGPFDFYLLNLKNELSIDVQNVQVNTSETREHTFIGLMPGELYRVELIVNSN
..|. |||.||... |   . | .||.. | . .... . .. . . ... |...|. || ||  |....   ..
nlsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavng
fn3 Fibronectin type III domain 2816-2888 1.6e-08 27.7 Pfam-A 1-80 (85) alignment 
Range on Protein: 2816-2888
Range on HMM: 1-80/85.0
DKPTDIMLSDLTTTSLTIDWKAP---LTSYQGFRLCWA-YGE---TNSLELGPAVMERTLSDLEAGAEYLVSLAAVVGTG
..|... .|. |.||||. |..|      ..|... ..  |.   ...  . .  .. ||..|..|.|| ....|| | |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag
fn3 Fibronectin type III domain 2912-2982 8.2e-09 28.7 Pfam-A 7-77 (85) alignment 
Range on Protein: 2912-2982
Range on HMM: 7-77/85.0
NITSFNTTAVSIVWGTD-IPLLDVSSYVVSYWETANNGSVQDISVDDPSQtDYTIDGLVPGTRYSFMVDALG
.... ..| ... |     .  ....| | |.|. ...  . ..|. ...  .|. || |||.|.| | |. 
svsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavn
fn3 Fibronectin type III domain 3200-3269 4.4e-11 36.0 Pfam-A 5-75 (85) alignment 
Range on Protein: 3200-3269
Range on HMM: 5-75/85.0
DLQFTSIGRNYVVLTWDNP---AGMIDSYNISYYPVNDITklMFEVVQAAAESNVLRVDDLNEGMNYSFTVVS
.|...... ....|.|. |    | |..|.. | ....        ... . .. . . .|..|..|.|.| .
nlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqa
fn3 Fibronectin type III domain 3296-3358 5.7e-09 29.2 Pfam-A 6-74 (85) alignment 
Range on Protein: 3296-3358
Range on HMM: 6-74/85.0
LNITAFDETTISIEWEQV-----DVEEYILSYDALEGGS-GNVTVQSTDPNSYTFTGLTPGTQYTIGVQ
|....  .|.....|.       ... | . |   .||.  .    . . .|.|.|||.|||.|.. ||
lsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVq
fn3 Fibronectin type III domain 3375-3443 8.8e-14 44.6 Pfam-A 2-73 (85) alignment 
Range on Protein: 3375-3443
Range on HMM: 2-73/85.0
PPTNLRTTMVAAQSITVSWDPPS--EGGSDTYNITYNVTGGQP-PSPHTVSTSETSVTFSNLTPLTEYFFTI
.|.||. . | . |.|.||.||.  .|  . |...|  .||.  .   ||. ..||||...|.| ||| |..
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrV
fn3 Fibronectin type III domain 3468-3541 1.6e-08 27.7 Pfam-A 6-79 (85) alignment 
Range on Protein: 3468-3541
Range on HMM: 6-79/85.0
LAVTPEDNTEFTVSWEDLD--TEAFEQYCVMYEPYEAQEnrQQESFPVARNIRSARFYGLDPGQEYTVYVTSCSSV
| |..  .|..|.||.  .   . .. | | |.. . .|  .  .| | |. .|. . || ||.||.. |.... .
lsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 3656-3726 2.3e-10 33.6 Pfam-A 1-76 (85) alignment 
Range on Protein: 3656-3726
Range on HMM: 1-76/85.0
DPPQNLVISEIGEDTATLSWADPA--EMNFDILEVVMTTM--PA-TKTTILKLNTNTVELTNLVPGQTYTVQLASV
..|.|| .||......||||  |.  . ...  ||   ..  .  .|.  .. .|..|.||.| ||..|......|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav
fn3 Fibronectin type III domain 3754-3832 1.5e-10 34.3 Pfam-A 2-84 (85) alignment 
Range on Protein: 3754-3832
Range on HMM: 2-84/85.0
SPSDISVSNNELTRVTVTWQPS---EGVVARYSYTYGLPGSTV-TASETTTTTDTSIQLSNLTPSTRYEFRLWAESDQTEGSE
.|...|||..  | .|..|.|.   .| . .|. .|   |..  . . |.. | || .|..|.|.|.||||. | ....|| |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 3869-3955 2e-07 24.2 Pfam-A 1-79 (85) alignment 
Range on Protein: 3869-3955
Range on HMM: 1-79/85.0
SAVGGLTITKTGIVDAEVSWSSPLLPNGVIANYSLTIHISHDNGtlspygdtVTISAVAEQTEYSQDVIGLAAGQYYVFSVYATNQV
||...|... ..   ...||| |  ..| | .|...   . ...        .. .  .. |..|  . || .|. |.|.|.| |..
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge........ewkeftvprtttsvtltgLkpgteYefrVqavnga
0050432 (Phosphotyrosine protein) phosphatases II 4230-4517 1.1e-93 309.2 In-house 18-299 (308) alignment 
Range on Protein: 4230-4517
Range on HMM: 18-299/308.0
PSTTHTRPTKKNMFAQHVAKmsARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLkGvAGTDYINASYIKDD--HGQKKYIAT
. .... ..    ..... |  | .. ... |.. |...   .  ..|.. .| |||||..|||||..|| | .  |.|||||||..    . ..|.|||
silvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.d.egsdYInAsyvdgyssklprkfIat

QGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG--EEPQLHGNVTVTLVGSNQTDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVP
|||||||.|.|| ||||.....|||.| ||| |. ||..|||    .... .|..||||.   . |... ||| |..  .| .|||||..|..| |||||
qgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvP

ESTAPLVGLLRQVKVTNQEdgaatGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
.|...|. .|..|. ....     |||||||||||||||||||.|.|.. ...      .|| ....|.||||.  |||. ||..|.|..| ..
pspeilldflelvrkslpg.....gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 4231-4519 1.9e-139 458.6 In-house 2-281 (288) alignment 
Range on Protein: 4231-4519
Range on HMM: 2-281/288.0
STTHTRPTkknmfaQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKG---VAGTDYINASYIKDDHGQKKYIAT
...|..|.      ..|||.||||..|||.|||.|.|.|||..|||.|.|.|..|||||||||||..||.||.   .||.||||||||......||||||
epihispv......akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiat

QGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTA
||||..|...|||.|.||.||||||.|.||||||||||.|||....|...|.||||||.|.....|..|.|||||..||...|.||||||.|||||||.|
qgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeska

PLVGLLRQVKVTNQEDgaaTGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
||..|||||||.||.|   ||||.|||||||||||||||.|.|.||...   .||||||||.||.|.|||||||||.||.......||||||
pllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
0039614 (Phosphotyrosine protein) phosphatases II 4231-4517 7.5e-88 290.1 In-house 7-289 (297) alignment 
Range on Protein: 4231-4517
Range on HMM: 7-289/297.0
STTHTRPTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTraVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG----TDYINASYIKDDHG-QKKYI
... . |.. ....... .. | .. ..  |. .|. .      . |.   | |||||..|||||..||.||.. |    .|||||||..  .  ..|.|
allesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfI

ATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKtKCEHYWPAGEEpqLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPES
|||||||.|.|.||.||||.....|||.| ||| |. ||..|||  ..   .|..||||..  . |... ||| ....| .|||||.||. | |||||.|
atqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvpps

TAPLVGLLRQVKVTNQEDgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
.. |  .|..|.  ..|.    ||..||||||||||||||||..... ...      .||  .....||||   |||. ||..|.. .| |.
lellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_PTPRB_pd Subfamily PTPRB 4233-4519 1.7e-123 406.3 In-house 2-287 (293) alignment 
Range on Protein: 4233-4519
Range on HMM: 2-287/293.0
THTRPTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQG
....|.|...|..||.||.|.....||.||..| |..|..||.||..|.|..||||.||||||..||.|   |. .|.|||||.||.. . ....|||||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPL
|||.|...||.||||...|.|||.|.|||.||.|||.|||| |||.|.|...|||| ........ |.|..||| .||.|..|....|.||||||.|..|
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

VGLLRQVKvTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
. ..|.|. ...|. |...|||||||||||||||||| |.|..||..   .||.|..|..|..||.|.|||||  |||..|..||.|...
ldfvrtvr.eaiektaskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0045450 (Phosphotyrosine protein) phosphatases II 4235-4517 9.1e-88 290.2 In-house 6-304 (307) alignment 
Range on Protein: 4235-4517
Range on HMM: 6-304/307.0
TRPTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEK--TRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG----TDYINASYI--------KDDHG
 .. .  .. ..|... . ...|.  |.. |. ...      ..|.   | |||||..|||||.|||.|. . |    .|||||||.        .  . 
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

QKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLE---KEGTERTVTHYQYLAW
..|.||||||||.|.|.||.|.||.....|||.| ||| |. || .|||  .|.. .||.||||.. .. |... ||| ..   ..| .|||||..|..|
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgw

TDHGVPESTAPLVGLLRQVKVTNQEDgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
 |||||.|...|. ....|.  ..|.    ||..||||||||||||||||..... ...   . ..|.  .....||||   ||.. ||..|.. .| |.
pdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPRA_pd Subfamily PTPRA 4236-4515 7.8e-74 243.5 In-house 12-293 (330) alignment 
Range on Protein: 4236-4515
Range on HMM: 12-293/330.0
RPTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLP
 |   . . . . . || .|  | .|.|.||| .   .. .| .  | .|||. ||||||..|| |   .||  .||||||.|.  . ..|.||.|||. 
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

NTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLE------KEGTERTVTHYQYLAWTDHGVPEST
.|.| || |.|| ...||||.| | |  ..||. |||  |    .||..|..  .. . ..  | .|..      .| ..| |. . . .| | |||  .
etvedfwrmiweqksativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

APLVGLLRQVKVTNQEDGAatgPIVVHCSAGVGRTGTFIAADMLMDAIQrstATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
  .. ||..|| .||  .    |||||||||||||||||. | ... ..   |   .|| ... ..| ||. .|||. || ......| 
iGmlkllkkvkklnqqsag...pivvhcsaGvGrtGtfivldavlervk...aerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 4236-4515 1.5e-62 206.5 In-house 8-282 (297) alignment 
Range on Protein: 4236-4515
Range on HMM: 8-282/297.0
RPTKKNMFAQHVAKmsARNNAGFSDEYNNLPAMeKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGT---DYINASYIKDDHGqkKYIATQGPLP
||     ||  | |   |.   ||.|.. ||.  .... | |..  | .|.||.||||||  ||.|. |      ||.|||..|  .   ..|.|| | .
rpiplsdfatlvqk..nrhtdvfseeflclpea.niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmk

NTIEHFWEMVWENQTSTIVMMTALVEGGKtKCEHYWPAGEEPQlHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPE--STAP
.|.. || ||...|.|||||.. . |. | || .||.     .  |.|.|.|   ..   ||.|.| ..|.   ..| |  ||.. | |. |..  |.. 
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

LVGLLRQVKvtNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
|. |. .|.  .. .. | ||..|||.||||||| ... |  .  ..|   .. .|. |.. |.|..|  ||||  || ... .|| 
llklisevr..kdfsqnaegPllvhclaGvGrtgvlltidsvvaeakr...ekevdifglvkklrqerpylvqtkeqykfvyvavle
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 4236-4329 2e-13 44.3 In-house 3-95 (95) alignment 
Range on Protein: 4236-4329
Range on HMM: 3-95/95.0
RPTKKNMFAQHVAKMSARNNAGFSDEYNNLPaMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGTDYINASYIKDDHGQKKYIATQG
.| .  .|  || .| .  .  | .|.. .. |    . |.     |  |||. ||.||| ||| |     .||||| ..     .. |||.||
kpihvsvfhshvlemhsnsdqefdnefksis.mtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 4236-4316 6.6e-10 32.9 In-house 4-84 (440) alignment 
Range on Protein: 4236-4316
Range on HMM: 4-84/440.0
RPTKKNMFAQHVAKmsARNNAGFSDEYNNLPAMEKTRAVTAaRQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIK
||     ||..| .   |    | ||.. ||.   . .  |     |  |||||||| ||..|| |   |||  .||||||||.
rpiivadfadyvqn..nrrsrafedewsllpsglsqpsdia.slpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_PTPRD_pd Subfamily PTPRD 4237-4518 2.3e-100 331.9 In-house 4-282 (564) alignment 
Range on Protein: 4237-4518
Range on HMM: 4-282/564.0
PTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMeKTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPN
| . . ...||||. | ... |. ||...    ..  ..||..  |  |||| ||..|| .|| |   .|. |.||||||.|.  . .|.||||||||..
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEePQLHGNVTVTLVGSNQTDNFIERTLLL--EKEGTERTVTHYQYLAWTDHGVPESTAPLVG
||| || ||||...|||||.| |.| ||.||..|||. . .. .|..||||. ...  ... ||. |  .|.   |.|..... .| |||||||...|. 
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

LLRQVKVTNQedgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
|.|.|. .|.     .||||||||||||||||||. |.... |.     . .|. ......|.||  .|||  |||..|...|  ..
lirkvralne...pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4237-4517 5.2e-73 240.8 In-house 3-283 (305) alignment 
Range on Protein: 4237-4517
Range on HMM: 3-283/305.0
PTKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTaaRQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPN
..  . .|... .... .. |.  .|..|.  |..  |.  ..  |  |||...| ..|  |..|.       .|||||||..  ...||||..||||.|
iialddlaayikearvysdkgleaqykslyeeeesidvg..kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEP-QLHGNVTVTLVGSNQTDNFIERTLLLEK---EGTERTVTHYQYLAWTDHGVPESTAPL
|.. ||....| ..|||||.| |||||| ||. |||  .   . .|...|.|  .... ..||| | . .   .  .|||..||   | |||||.... |
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

VGLLRQVKVTNQEDGaaTGPIVVHCSAGVGRTGTFIAADMLMDaiqRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
. |...|. . ..|     |..|||||||||||.||| |. ..   |  . . .||.. . ..|..|  .|||| || .||  .  ||
lslikrvqkdqkkdk..gvpllVhCsagvgRtGvfiavdiale...rlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
0051299 (Phosphotyrosine protein) phosphatases II 4238-4517 8.6e-95 312.7 In-house 5-286 (288) alignment 
Range on Protein: 4238-4517
Range on HMM: 5-286/288.0
TKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNT
 . . ....| |. |....|. .|.. |...  .. ..||.   | .||||..|||||..||.|. . |   .||||||||.  . ..|.||||||||||
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

IEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLE------KEGTERTVTHYQYLAWTDHGVPESTAP
.|.|| ||||.....|||.| ||| |..||..|||  .... .|..||||.   . |... ||| ..      ..|..|||||..|..| |||||.|. .
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

LVGLLRQVKVTNQedgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
|. .||.|.  ..   .  ||.||||||||||||||||.|.|.. ...      .|| ......||||  .|||. ||.......| ..
lldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 4238-4517 6.9e-78 256.9 In-house 9-290 (298) alignment 
Range on Protein: 4238-4517
Range on HMM: 9-290/298.0
TKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEK---TRAVTAARQARNDDKNRYRNILPYDYTRVQLKG---VAGTDYINASYIKDDHGQKKYIATQGPL
. |... . .|.. . . .|...|...| ....   .   ..||. .| .|||| .|...|..|| |.       .||||||...  .|.. .||||.||
dlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPl

PNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVPESTAPL
..|.| || ||.|.. .||||.| |.| .|||...|||  |. . .|..||.|  ...  ..| |.| ..|  | .||.| . ..  |.|.|||| .  .
tetvedFWrmvteedigtiVmltnleeldktkyhkywPd.egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsv

VGLLRQVKVtNQEDgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
..|||.|.  .|.. |   |..|.|||||||.||||| | ... ....     .||  ..  .|..|. .|||  ||....  ||  .
ldllrkvra.sqqq.agnkpvivqCsaGvgRsGtfiaidsvlervkke...qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 4238-4519 4e-45 148.9 In-house 4-289 (305) alignment 
Range on Protein: 4238-4519
Range on HMM: 4-289/305.0
TKKNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEH
..|.   . | .   .  ||.  |....  ..    . | ..|.. .||||...   |  ||.|.|    .|| | |.      |..| || || .|   
qqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcad

FWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHG-----NVTVTLVGS------NQTDNFIERT-LLLEKEGT-ERTVTHYQYLAWTDHGVPE
|| | ....  .| |.  |.| |  || .|... ....|.       ..| .  |      ....  ...| |..|  |.  | |||| .  | | ||| 
fwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa

STAPLVGLLRQVKVtnqedgaATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDyiDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
.   .. || . ..       . ||||||||||.||||. .  . ..| .      .  |    . ||||||   .||  ||...|. .|  ...
adlailellekarp.......skgpivvhcsagigrtgsvvmleyildqllagqiie..dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4240-4515 1.2e-56 187.1 In-house 4-277 (439) alignment 
Range on Protein: 4240-4515
Range on HMM: 4-277/439.0
KNMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARN--DDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNT
.. | .|| |.   ..  |....... ...   |. |.  |..  . ||||... ..|.||| |    ||  . |||| |||  . .| |||||||  .|
rdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

IEHFWEMVWENQTSTIVMMTALVEGGKtkcehYWPAGEEpQLHGNVTVTLVGSNQTDNFIERTLLL--E--KEGTERTVTHYQYLAWTDHGVPESTAPLV
 ..|| .|.|..|.||||.| |||  |     |||. .|   .|...|      .  |.. | . .  |  .   |||| ...|.|| |. ||  .. ..
tddfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl

GLLRQVKVTNqeDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQrstATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
 .|| .. .|  |   .||.||||||||||||| || |. .. ..   . . .|. | .  .|.||  .||.| ||.... .|| 
dflrainsan..dkeeygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 4241-4517 1.1e-86 285.7 In-house 5-280 (318) alignment 
Range on Protein: 4241-4517
Range on HMM: 5-280/318.0
NMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEH
. ...||... .  .  .| ||..|   |.| . . . .  |  |||| |||.|| |||.|.   |. |.|||||.||   . .|.|||.|.|||.||| 
edleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieD

FWEMVWENQTSTIVMMTALVEGGKTKCEHYWPaGEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRQ
|| |||| ....|||.| ..| ||.|...||| ..... .|...|.|  . ...... |.. .....   .|.|  |.| .|.|.|||||.| |. |.||
fWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrq

VKVTNQEDGAatGPIVVHCSAGVGRTGTFIAADMLmdaIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
|. ..|. ||  |||||||||||||||.||| |.|   ..|  |   .|| .|. ..|||| |.|||  ||.... ..|  .
vskaqqksga..gpivvhCsaGvGrtGvfiavdil...lerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 4241-4518 3.1e-80 264.6 In-house 8-284 (319) alignment 
Range on Protein: 4241-4518
Range on HMM: 8-284/319.0
NMFAQHVAKMSARNNAGFSDEYNNLPAMEKTrAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEH
. ..... .. .  . ..  |...|   ...  .. | . .| .||||.|||.|| |||.|   .|| |.||||||.|   . ..|.||||.|| |||| 
qeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentied

FWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTE---RTVTHYQYLAWTDHGVPESTAPLVGLLR
|| ||||...|..||.| ||| .| |...|||  |...  |...|||   ......| | | |.|  .|   |.|.|.||..|.||.|||..  |. ||.
fWrmvWeeessivvmltklveklkvklkkywpe.enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllk

QVKVTNQedGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
... . .  .   ||||||||||||||||||. |. .. ... ..   .||  |. ..| || ..||.  ||.... ..|  .|
rirksre..ktqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_PTPRG_pd Subfamily PTPRG 4241-4518 8.2e-80 263.6 In-house 4-288 (563) alignment 
Range on Protein: 4241-4518
Range on HMM: 4-288/563.0
NMFAQHVAKMSARNNAGFSDEYNNLPAMEKTR--AVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG----TDYINASYIKDDHGQKKYIATQGPLPNT
. ||.|||.. | .. ||| |...|    ...   ......  |  |||| ||..|| .||.|....|     |||||.||.  . .|..|||||||..|
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

IEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLEK-------E-GTERTVTHYQYLAWTDHGVPEST
.. || |.||.....|||.| ||| |. ||. |||. .|..  |...|||. ....    .||| ...       .  ||..|..|.|  | ||||||..
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs

APLVGLLRQVKVTNQEdgaATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
.| .   .. . .|..   ..||||||||||||||||.|. | |.  ||.    . ..| |.. .|| ||  ||||  |||.|| ..|..| 
lpvLifvkkssaanka...eaGPivvHcsaGvgrtGtyivldtllkqiqqe...navnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 4241-4514 6e-68 224.1 In-house 9-276 (315) alignment 
Range on Protein: 4241-4514
Range on HMM: 9-276/315.0
NMFAQHVAKMSARNNAGFSDEYNNLPAMeKTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEH
. .  .||.  |  . || ..|...|   . . .  |..  | .|||| ||..|| .||||   .   ..||.||..|.    ...|||.|||...... 
dqlityvaqkkastkngfkqdyesipgg.qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkd

FWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGeePQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVK
|| .|.|.. ..|||.| |||| | |.|.|||      ..|..|||..  .. ...  |||    .   |.|  ..| .| | |||..| ||. | |.||
fwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvk

VTNQEDGaatGPIVVHCSAGVGRTGTFIAADMLMDaiqRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
. ....    |.||||||||||||||||. | ..|   .  | . |||   | ..|..|  .||.. || ... ..|
qhhtnsv...gaivvhcsaGvGrtGtfitldavld...qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 4241-4518 7.2e-66 217.0 In-house 5-284 (290) alignment 
Range on Protein: 4241-4518
Range on HMM: 5-284/290.0
NMFAQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGT-----DYINASYIKDDHGQKKYIATQGPLPNTI
. |...||.  |..| || .... | . |.  .|| .    |  .||..||..||  |. |. ..|      .||||.|||. . .|.|||||||..||.
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntl

EHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQlHGNVTVTLVGSNQTDNFIERTLLLEKEGT---ERTVTHYQYLAWTDHG-VPESTAPLVG
 .||...|..... |||.|  .| ||.||  |||. .  .  |.....|.  ......|||.| .... .   ...||.||  .| ..| |.. .. |. 
vdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

LLRQVKvTNQEDGaaTGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
. ...| |.  .|   ..||||||..|||...|.||..   .|..   .  |||   . . | |.  .|||  || .... ||. ..
ieemyk.tqrkrg..ntsivvHCSdtvgrsavfcaaat...tinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4241-4517 1.8e-63 209.2 In-house 5-278 (287) alignment 
Range on Protein: 4241-4517
Range on HMM: 5-278/287.0
NMFAQHVAKMSARNNAGFSDEYNNLPA-MEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAgTDYINASYIKDDHGQKKYIATQGPLPNTIEHFW
..|.. |||  |..| ||.. .  |    ..   || .   .| ||||...||..|  || |||    |||||..|.  . .|..|....|. ||.  ||
ekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgeh.pdyinavfidgykekkafiiaesPmfntarnfW

EMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEpQLHGNVTVTLVGSNQTDNFIERTLLLE---KEGTERTVTHYQYLAWTDHG-VPESTAPLVGLLRQ
....... ..|||.. . |  . .| .||| ..   . |. ...|.  ......|||.| ..   |.|....|. ||. .| ..| |.|  . |. . ..
kliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem

VKVTNQedgAATGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
.|   .    . ..||||||..|||...|.||..   .|...     |||   . . | |.   |||  ||...   ||  .
yktqrk...rgntsivvhCsdtvGrsamfcaaat...tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 4242-4516 5.2e-47 154.9 In-house 13-282 (290) alignment 
Range on Protein: 4242-4516
Range on HMM: 13-282/290.0
MFAQHVAKMSARNNAGFSDEYNN-----LPAMEKTRAVTAARqaRNDDKNRYRNILPYDYTRVQLKGVAGTDYINASYIKDDhgQKKYIATQGPLPNTIE
 | .  ...  .|  ... || .     ||.    | .  .    .  ||||...   | ||| ||     ||. | |.|    .  .| |||.| .|. 
afekfasdvvkknvdelakeyleklkpylpvqylerkifdkn..tefkknrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvi

HFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQL-HGNVTVTLVGSNQTDNFIERTLL---LEKEGTERTVTHYQYLAWTDHGVPESTAPLVGL
 .| || ......|||.  |.| ||.|||.|.|  |   |  |..||.   ... |. | . .|     ..| |  . |..  .| |. |. ||  |. .
diwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrt

LRQVKvtnqedgAATGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
|| ..        |.||.|||||||.||||||.| ..   ..|  .    .|.....  .|. |.  ||   ||. | . .| |
lrilr.......kasGpvvvhcsaGiGrtGtfvaiev...glqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
0040438 (Phosphotyrosine protein) phosphatases II 4243-4517 2.5e-89 295.0 In-house 5-276 (317) alignment 
Range on Protein: 4243-4517
Range on HMM: 5-276/317.0
FAQHVAKMSARNNAGFSDEYNNLPAMEKTrAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNTIEHFW
. ... .. .... ....|...|. . .    . |.   | |||||..|||||..||.|. . |   .|||||||..  . ..|.||||||||||.|.||
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

EMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVK
.||||.....|||.| |.| |. ||..|||  .|.. .|..||||..  . .... ||| .|  .....|||||..|..|.|||||.|. .|. .|..|.
rmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

VTNQedgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTatdYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
  ..      ||..||||||||||||||||..... ...      .||  .....||||.  |||. ||..|.. .| ..
eale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleyl
0043336 (Phosphotyrosine protein) phosphatases II 4243-4516 1.1e-85 282.8 In-house 7-276 (278) alignment 
Range on Protein: 4243-4516
Range on HMM: 7-276/278.0
FAQHVAKMSARNNAGFSDEYNNLPAMEKtRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNTIEHFW
........ . ...... |. .|. . .    . |.   | |||||..|||||..||.|. . |   .|||||||..  . ..|.||||||||.|.|.||
llkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

EMVWENQTSTIVMMTALVEGGKTKCEHYWPagEEPQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVK
.||||....||||.| ||| |..|| .|||  .... .|..||||.. .. |... ||| ..  ..| .||||||.||.| |||||||...|. .|..|.
rmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavr

VTNQedgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTatdYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
  ..      ||..|||||||||||||||...|.. ...      .|.  .....||||.  |||. ||..|.. .| .
eale...dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 4244-4519 1.5e-86 285.0 In-house 3-278 (281) alignment 
Range on Protein: 4244-4519
Range on HMM: 3-278/281.0
AQHVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWE
 .|....|. .||||  ||..| |..   . ||...  |  ||||.||  || |||..   .    ||||||....  .|.|.|||||||.|.....||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLL-EKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVT
||||.. |.|||.|. .|.|| || .||| ...    |.|||. . .... ..|||.. | ...| .|.|.. .|.|| |||||..|. |..  ..|. .
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

NQEDGAatGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
....     |.|.|||||||||||.|| | |..|.....    .||  ..|..|..| |.|||. || .....||  ...
tekktk..aplvihCsaGvGrtGtyialDrlvkaveael..eeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPRK_pd Subfamily PTPRK 4244-4515 5.1e-71 234.1 In-house 10-275 (314) alignment 
Range on Protein: 4244-4515
Range on HMM: 10-275/314.0
AQHVAKMSARNNAGFSDEYNNLPAMektraVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGT---DYINASYIKDDHGQKKYIATQGPLPNTIEHFWE
 |..|.. . .. || .||..|.         ||..  | .|||. .||.|| .||.|. . |    |||||..|   .  ...|.|||||..|.. || 
lqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWr

MVWENQTSTIVMMTALVEGGKTKCEHYWPagEEPQLHGNVTVTLVGSNQTDNFIERTLLLEK----EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQV
.|.......|||.| ||| |. || .|||  |. . .|.. |.|| ..   ... |.. .||        |.| ..|.|.|.||.|| |   |..|.|.|
lvydencasivmltelvevgrvkClkyWP..edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrv

KVTNQEdgaATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
| ...|     |.|||||||| |||||||| |...| |.|    . .||  .. ..|...  .|.|  ||....  .| 
kksqee...eaGrivvhCsaGaGrtGtfiaidivldmiere...gvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 4244-4513 8.2e-61 200.9 In-house 11-284 (325) alignment 
Range on Protein: 4244-4513
Range on HMM: 11-284/325.0
AQHVAKMSARNNAGFSDEYNNLPAMEkTRAVTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWE
 .|| |  |... ||. |.. ||. . . | ..| .  | .|||..|....| .|| |.     . .|||||||..|| ... ..|.| ||..||. .| 
vehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWr

MVWENQtSTIVMMTALVEGGKTKCEHYWPAG-EEPQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVK
.| . . ...|...  ...|| .|  |||    . .  | . | |.  ..  ... | | .   |.|  |.|  .|. .| | ||..  | |. .|. ||
lvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvk

VTNQEDG---AATGPIVVHCSAGVGRTGTFIAADMLMdaiQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
  ..       |..||.|||||||||||.||.   ..   ..      .|. | . |.|..|  .|.|  ||| .. ..
avservtantkastpilvhcsaGvGrtGvfislysal...akvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal
subfamily_PTPN9_pd Subfamily PTPN9 4246-4515 3.4e-72 238.0 In-house 6-288 (297) alignment 
Range on Protein: 4246-4515
Range on HMM: 6-288/297.0
HVAKMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVA---GTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMV
 || . .... | | || .. ... .  ..|...  |  |||| ..| || |||.|. |     .|||||...   . .| .|||||||..|.. || ||
lvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmv

WENQTSTIVMMTALVEGGKTKCEHYWPAGEE-PQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVK--
||... .|||.| .|| |. || .||| .||  . .|...|. |  ...... .|.| ..  |.. .|.|||.|.|.| |.|||.|.| |. .|..|.  
WeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrek

-------VTNQEDGAATG-PIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
       ..... | ..| |||||||||.|||||||. |. .. ...   .. .||  |. ..|.|||  .||  || . . .|| 
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee...vgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 4247-4515 9e-43 141.3 In-house 10-269 (288) alignment 
Range on Protein: 4247-4515
Range on HMM: 10-269/288.0
VAKMSARNNAGFSDEYNNLPAMEKTRAVTAarQARNDDKNRYRNILPYDYTRVQLKgvA-GTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWEN
. ..     .|   ||.. |     .....     |  ..||.|.   |.|||.|.       ||.|  .   . ... | .| ||  ||| .|.|. |.
irlvlqiaveglkkeyrdspneasidiids..fianptrdryenlprcditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmlles

QTSTIVMMTALVEGGKTKCEHYWPA--GEEPQLHGNVTVTLVGSNQTDNFIERTLLL-EKEGTERT-VTHYQYLAWTDHGVPESTAPLVGLLRQVkvtnq
.   |||.. |.| || | ..|.|   ||. ..  . ||. .  .. |  .. .||  .||| |.  | .  .| | |.||||.  . . ||  .     
dveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....

edGAATGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
   . . |||||.|||||||||.|   .   |..    .|.. .   .|| ||.|   .||  ||.|.|| || 
..kslqkPivvhssaGvGrtgtlilili...aleslrlddflgirsllaklreerfkaiqtemqylyvhrcvle
0036941 (Phosphotyrosine protein) phosphatases II 4249-4517 9.4e-89 292.9 In-house 6-277 (297) alignment 
Range on Protein: 4249-4517
Range on HMM: 6-277/297.0
KMSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLkGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTS
.... ..|... |.  |. . .    ..|.  .| .||||..|||||.|||.| .  |.|||||||..  . ..|.||||||||||.|.|| ||||....
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

TIVMMTALVEGGKTKCEHYWPAG-EEPQLHGNVTVTLVGSNQ--TDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQED
.|||.| ||| |. ||..|||   .|.. .|..||||.. ..   |... ||| ...  .| .|||||..|. | |||||||.|.|. ....|.  ... 
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

--GaatGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
  |   ||..|||||||||.|||||||.... ..... .  .|.  .. |.||||.  |||| ||..|....| |.
psg...gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_PTPN6_pd Subfamily PTPN6 4250-4519 1e-83 275.9 In-house 20-299 (306) alignment 
Range on Protein: 4250-4519
Range on HMM: 20-299/306.0
MSARNNAGFSDEYNNLPAMEKTRA--VTAARQARNDDKNRYRNILPYDYTRVQL--KGVAGTDYINASYIKD--DHGQKKYIATQGPLPNTIEHFWEMVW
 .  ..|||..|...|  .|...    . .....|  ||||.||||.| ||| |  ..|.|.|||||.|||.     .|.|||||| |..|.. ||.|||
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

ENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLE---KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTN
....  |||.|  || || || .|||. || . .|...|| | .......| |.|...   |...||.| .|.. .| |||||...  .. .|..|.  .
qensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkq

QEDG-AATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
.|   | .||||||||||.|||||||  |.|.. |...     ||.  .. ..||||  ||||  || ......   ||.
eeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Ptp69D_pd Subfamily Ptp69D 4250-4516 4e-72 237.9 In-house 16-285 (307) alignment 
Range on Protein: 4250-4516
Range on HMM: 16-285/307.0
MSARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQ
     . |.  ||..|.| |  .  ... .  |  |||| .| ..| |||.|| . |   .||||||.||  . .||.|| |.|. .||. || |..| .
rkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

TSTIVMMTALVEGGKTKCEHYWPAGEEPQlHGNVTVTLVGSNQTDNFIERTLLLEKEG-------TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVT
  .|||.. | |  . ||..|||  .| | .|.. |.|| .......|.|.| . | .        .| |. |.|..| |  |||..  |. |..||.  
vtlivmlsnlteknrkkcakYWpiedevq.ygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

NQEDgaaTGPIVVHCSAGVGRTGTFIAADMLMdaiQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
.. .    .||||||||||||.|.|.| |.|.   |.  | | .|.  |. ..|.|| |||| | ||..|.| .|  
ykln...rsPivvhCsaGvgrsgifvaldsll...qqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 4250-4513 2.1e-46 153.0 In-house 9-289 (301) alignment 
Range on Protein: 4250-4513
Range on HMM: 9-289/301.0
MSARNNAGFSDEYNNLPAMEKTRAVTAArQARNDDKNRYRNILPYDYTRVQLKGVA-----GTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWE
. | .. .|...|..|  .|. ...    . .|   ||..|| .||  |. ||         ..|||||||..   .||.||.|||. .|.  || ..|.
vaakhsnkfeeqykelkegedksctvgl.seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

NQTSTIVMMTALVEGGKTKCEHYWPAGEE-PQLHGNVTVTLVGSNQTD-----------------NFIERTLLLEKEGTERTVTHYQYLAWTDHGV-PES
.....|||.| | || |.|||.||| .|.  .  |..||||| ..                    ..|||..  ... . ..|. .|   | ..|| .| 
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

TAPLVGLLRQVKVTNQedgAATGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
   |  .  ... ...      ||.|||||..|.|.|.... ..   ..    |   .|| . .  .| ..   |.|| ||. ..  .
rtvLqviddvihrqqk...igggpvvVHCSdtVsrsGvYcsvsi...glEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi
0047943 (Phosphotyrosine protein) phosphatases II 4251-4517 2.8e-89 294.5 In-house 7-272 (273) alignment 
Range on Protein: 4251-4517
Range on HMM: 7-272/273.0
SARNNAGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLkGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTI
.. .....  |.. |. . .    ..|.  .| |||||..|||||..|| | |  |.|||||||..  . ..|.||||||||||.|.|| ||||.....|
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMMTALVEGGKTKCEHYWPAGEE--PQLHGNVTVTLVGSNQTDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQED--G
||.| ||| |. ||..|||  ..  .. .|..||||.. .. |... ||| |..   | .|||||..|. | |||||.|...|. ....|. .....  .
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

aatGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
   ||.||||||||||||||||.|.|.| ...      .||  .....|.||   |||. ||..|....| ..
...gpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4251-4514 9.2e-70 230.0 In-house 14-274 (315) alignment 
Range on Protein: 4251-4514
Range on HMM: 14-274/315.0
SARNNAGFSDEYNNLPAMEKTRaVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQT
  |. | ||.|...||  .  |  ..||.  |  ||||.||||.| .||.|         |||||||||  . .| |||.||||. ... ||.||.....
knrhtalfseefhdlpdPdiyr.qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekv

STIVMMTALVEGGKTKCEHYWPA-GEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTnqeDGAA
.||||.| . || | ||  |||    .    |.. |.|.  ... . . | | . |  . |||| .|.  | |.||.. |. |. |...||     .|  
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad...ngkk

TGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
. ...||||||||||| .|..|  .. |.|   |. .||  .. ..|..|  ||||  .| ... .||
efsllvhcsaGvGrtGvvisidevvaqikr...trsvdvfnfvknlrakrpylvqteeeyafiydavl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 4251-4514 1.9e-52 173.0 In-house 15-233 (392) alignment 
Range on Protein: 4251-4514
Range on HMM: 15-233/392.0
SARNNAGFSDEYNNLPAMEKTrAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQT
  | .| |..|. .||  .     |.|..  |  ||||.|||||| .||.|     .. .||.|||||.  . .| |||.||| . ... ||.||.....
knrhsalffeefhdlpgpdiy.pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenv

STIVMMTALVEGGktkcehywpageepqlhgnvtvtlvgsnqtdnfiertllleKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVtnqEDGAAT
.||.|.| | ||                                          |    |||. ...  | |..||. |. |. ....||.   . |  |
ttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka...dfGqyt

GPIVVHCSAGVGRTGTFIAADMLMdaiQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
 |...||||||||||  |. | ..    ..  |  .||   ...||..|  .|||  || ... .||
hpliihcsagvgrtgvvisidsvv...ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 4252-4514 1.4e-68 226.3 In-house 14-273 (515) alignment 
Range on Protein: 4252-4514
Range on HMM: 14-273/515.0
ARNNAGFSDEYNNLPAMEkTRAVTAARQARNDDKNRYRNILPYDYTRVQL---KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTS
.|. . ||.|...||  .     | |..  |  ||||.|||||| .||.|   .     ||.|||||.  . .| |||.|||.. ... || .|......
nrhttlfseefhdlpgpn.iypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvt

TIVMMTALVEGGKTKCEHYWPA-GEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVtnqEDGAAT
||.|.| | || | || .|||    .    |.. | ||  .   . | |.| . |.   |||| ...  | |.|||. |  |. |...||    . |  |
tiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevka...dhgqyt

GPIVVHCSAGVGRTGTFIAADmlmDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
 |...|||||||||| .|..|   . . .   |. .||  .. .||..|  ||||  || ... .||
hpliihcsaGvGrtGvvisid...svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 4252-4514 1.5e-58 193.0 In-house 5-263 (283) alignment 
Range on Protein: 4252-4514
Range on HMM: 5-263/283.0
ARNNAGFSDEYNNLPAMEKTRAVTAARQarNDDKNRYRNILPYDYTRVQLKGVAGtDYINASYIK---DDHGQKKYIATQGPLPNTIEHFWEMVWENQTS
. ||  | . ...|   ..   ...|..  |. |||...|.|.|  ||.||  .  |||||..|    ... .||||..|.|| .|.  || ||.... .
vnnnklfrevlkrlsvpdldadiasade..nkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

TIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTE---RTVTHYQYLAWTDHGvpeSTAPLVGLLRQVKVTNQEDGA
.|||.| | |. . ||  |||  .  . .|. ||||      . || . ||| ....      ..|||.  |.. |     |..  |..  ||  .    
aivmltklqedlrikCsqyWPk.rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg...eqaiinslvkfnkvislqtes

ATGPIVVHCSAGVGRTGTFIAAdmlMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
  ||||||||.|.|||..||||   . ...   .   .||  ..  .||||  .|||| ||  .|  ||
kkgPivvhCstgiGrtavfiaa...sasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 4252-4518 1.9e-19 64.2 In-house 20-286 (302) alignment 
Range on Protein: 4252-4518
Range on HMM: 20-286/302.0
AR--NNAGFSDEYNNLPAMeKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAgTDYINASYIKDDHGQKKYIATQGPLPNTI---EHFWEMVWENQ
 .  ..|   .|.... .| |. .       .| .||.  ..  .| ..|.|.. .  .|.||| ..  . ... | .| |  ..    |.|| ||....
vksldtaevkkefkkidtm.kvdlekCkafkknlkknqsedvpildsnlvkleaep.dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqek

TSTIVMMTALVEGGKtKCEHYWP-AGEEPQLHGNVTVTLVGSNQTDNFI-ERTL-LLEKEGTERTVTH-YQYLAWTDHGVPESTAPLVGLLRQVkvtNQE
  ..|..    |  |   ....|   .. . .|.. |     .....   . .. .| .. ..  ..  |    | .. ||.. | |.    .|    ..
ivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv...fak

DGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDyidVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
.  |. ..|.    |.|| |.|... . .. .|.. .     .. ....||.||.  |..| ||. |....| .| 
kikadentvivSknGaGRagafltlavaveklqkgkepn...ikeivksiRsqRpravdslkQyvslyialllyik
subfamily_CG7180_pd Subfamily CG7180 4253-4515 6.1e-50 164.5 In-house 14-288 (296) alignment 
Range on Protein: 4253-4515
Range on HMM: 14-288/296.0
RNNAGFSDEYNNLPAMEKTRAVTaARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTST
. .. .  |..  | .|     . . .. | .|||. ...||||.|| |. . |   .|||||.|.     .|.|| |..|  .|.. ||..|.....|.
kfrveyklelkltprleigdCag.glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

IVMMTALVEGGKtKCEHYWPAGEePQLHGNVTVTLVGSNQTDNFIERTLLLEKE------------GTERTVTHYQYLAWTD-HGVPESTAPLVGLLRQV
.|..|   .  | ..  |||     . .|.. | .| ..|  |.  ||. | |.              .|.|...|.  |   . || ||. |. |.|.|
vvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

KVTN--QEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
..     ..   .||.||..| |..|.| ..|.|. .. ...   .. .|| . . ..|..|  ||..  .| |.  ..| 
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvek...eeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_PTPRN_pd Subfamily PTPRN 4254-4513 3.8e-56 185.0 In-house 27-288 (297) alignment 
Range on Protein: 4254-4513
Range on HMM: 27-288/297.0
NNAGFSDEYNNLPAMEKTRAVT-AARQARNDDKNRYRNILPYDYTRVQLKGVA---GTDYINASYIKDD-HGQKKYIATQGPLPNTIEHFWEMVWENQTS
|.  .. |.. | | |   ... .|.. .| .|||....|||| .||.||  |    .|||||| | |.   .  ||||||||..|. .||.||||. . 
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

TIVMMTALVEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSN-QTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQedGa
 ||..| | | | ..|..|||  |  ....   | ||     .|... |.. |        |||| . .|.|...||| |. .|. . |.|  . .  | 
vivnltrleeegvkqckrywpd.eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..G.

ATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
 . |||||||.|.||||..|. |.... ...      ||.| |. ..|.||. ||.|  |. .   .|
rscpivvhcsdGaGrtGvyilidlvlnrllkGv..keidiaatlehlrdqrpglvktkdqfefaltav
subfamily_PTPN23_pd Subfamily PTPN23 4255-4516 2.2e-64 212.0 In-house 14-279 (288) alignment 
Range on Protein: 4255-4516
Range on HMM: 14-279/288.0
NAGFSDEYNNLPAME--KTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVaGTDYINASYIKDD-HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIV
....  ....|   .  ..|  . |   .. .|||.|.||||| .||.|.|    ||||||..||   |  ..||||.||..|.  || ||.|...|.||
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgs.kDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviV

MMTALVEGGKTKCEHYWPAG-EEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGT--ERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKV-TNQEDGAAT
|..   | ||.|...|||.  .|.. .|...|||   ..|....||.| || ...   ..|.| |. .|...|||.|   |. .| .|.   ...   . 
mllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksk

GPIVVHCSAGVGRTGTFIAADMLMDAIqrSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
 |.||||||||||||.|      . ..  ..    .|.   . ..||||   ||.  |.  .   ||  
tPlvvhCsaGvgRtgvfalvyaavrel..ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4256-4514 2.1e-44 146.3 In-house 11-266 (281) alignment 
Range on Protein: 4256-4514
Range on HMM: 11-266/281.0
AGFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKG----VAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIV
  | .|. |||    .  .|.  |  |. |||| ||   | .|||||        |||| | ||.    .. || ||||  .|   || |.|...|..||
ddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MMTALVEGGKTKCEHYWPAGEEPQLH-GNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKvtnqedgAATGPI
|.  ..|  . ||  |.|      |.  ...|.   |     ..   | |  ||  | .||. .  | |  ||||.  .. .||...       | . | 
mlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir.......arstpp

VVHCSAGVGRTGTFIAADMLMDAIQRSTAtdYIDVAGTIAKIR-EQRALLVQTLYQYIYLHRTVL
|.||||||||.||..| .. ...|.   .    |.   ....|   ||  |||| ||. . . .|
vihcsagvgrsgtlmaveialqsihshft..lpdikqivshlrvtgraasvqtlqqymliwkvll
0045098 (Phosphotyrosine protein) phosphatases II 4257-4517 1.1e-78 259.7 In-house 8-272 (278) alignment 
Range on Protein: 4257-4517
Range on HMM: 8-272/278.0
GFSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQlkgvagtDYINASYIKDDhgQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTAL
 .. |. .|...     .| |    | |||||..|||||..||        ||||||||.    .||.||||||||.|...||.|.||.....|||.| |
dlllefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltel

VEGGKTKCEHYWPAgEEPQLHGNVTVTLVGSNQTDNFIERTLLLE------KEGTERTVTHYQYLAWTDHGVPEST--APLVGLLRQVKVTNQE------
||.|. ||..|||  .... .|..||||.   ..|... ||||..      .....|.|||..|| | |||||...  ...  ||....  ...      
velgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------DGaatGPIVVHCSAGVGRTGTFIAADMLMDAIqrstaTDYIDVAGTIAKIREQRAL-LVQTLYQYIYLHRTVLSLI
       .|   ||..||||||||||||..||..... .      . .|.  .....|.||    ||.| ||..|.. .| |.
sslllldsg...gpvlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4257-4517 1e-49 164.2 In-house 17-277 (307) alignment 
Range on Protein: 4257-4517
Range on HMM: 17-277/307.0
GFSDEYNNLPAMeKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKG-VAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTA
 . ||...|  . .  .||.     | |||||...   | .|. .|   . .||| | |.      ||.|..|||| ||. .|| |. ...  ...|.  
alvdefrvlakk.tpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

LVEGGKTKCEHYWPAGEEPQL-HG----NVTVTLVGSNQ---TDNFIERT-LLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVtnqEdgaa
..| .| ||| |||. |  .| .|     ..|. .|...    ...|. | | ..  .  ||..|.|.  | |.|||.     . ||  |.    .    
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry...d....

TGPIVVHCSAGVGRTGTFIAADMLMDAIQRStaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
| |.||||||||||.|| .|  ...| . .    .  |.   . ..|.||   .|| .||.|||| .|.  
tnpvvvhcsaGvGrsGtivaislvqdkmiaG..inckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 4257-4513 5.9e-41 135.2 In-house 7-255 (267) alignment 
Range on Protein: 4257-4513
Range on HMM: 7-255/267.0
GFSDEYNNLPAMEKTRAV-TAARQARNDDKNRYRNILPYDYTRVQLKGVaGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTA
 .  |....  . .|..  .      |...||. . |||| ||| |.     .||||||..  . ....|.||.|| ||| .|.... ... ..||..| 
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

LVEGgktKCEHYWPAG-EEPQLHGNVTVTLVGSNQTDNFIERTLL-LEKEGTERTVTHYQYLAWTDHGVP-ESTAPLVGLLRQVKVTNqedGaaTGPIVV
  ..   .   .||    . . . ..||     .. ...   ||    |. . . || | |  |           ||.|.| . .. |   |    |.||
vftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlen...g..nrPlvv

HCSAGVGRTGTFIAADMLmdaIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
.||.||||.|||. .|     ..|    .  |.   . |||.||  ||.|. .|||.|...
acsdGvGrsGtflvidsq...leraktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 4257-4516 1.9e-31 103.8 In-house 28-289 (310) alignment 
Range on Protein: 4257-4516
Range on HMM: 28-289/310.0
GFSDEYNNLPAMEKtRAVTAARQARNDDKNRYRNILPYDYTRVQLKG--VAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMT
|.  .| .| | .   ..|     ..  |||| ...  | .||.||       ||| | |.| .. .. .| .||||  ||  || |...... .|... 
glvkqyrkldakqd.ssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

ALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQT--------DNFIERTLLLEKEG---TERTVTHYQYLAWTDHGVPESTAPLVG--LLRQVKvtnq
  .| |. ||  |||.    . .| . || ..              |.   . ....     |  |.  ..  | | |||.     |   || ||.    
kvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr....

edgaaTGPIVVHCSAGVGRTGTFIAADMlmdAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
      || |||||||..|... .| ..   .|...   ...|.   ..... .||  .||  ||....|  . .
.....hgpcvvhcsagkdrlyvvvalkl...kidkldrglkvdaeevktellksraiciqtelqyliidrvriif
0046845 (Phosphotyrosine protein) phosphatases II 4258-4517 7.5e-91 299.7 In-house 2-274 (284) alignment 
Range on Protein: 4258-4517
Range on HMM: 2-274/284.0
FSDEYNNLPAMEKTR--AVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG----TDYINASYIKDD-----HGQKKYIATQGPLPNTIEHFWEMVWENQ
. .|.  |. .  ..   ...|.   | .||||..|||||..|| || . |    .|||||||..       . .||.||||||||||.|.|| ||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TSTIVMMTALVEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLEK---EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEd
...|||.| ||| |..||..|||  .|.. .|..||||.  .. |... ||| |..   .| .|||||..|..| |||||.|...|. .||.|.  ... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.

GAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
    |||||||||||||||||||.|.|.. ...   .  .|| ......||||   |||| ||.......| ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
DSPc_SM00195 4258-4517 1e-87 289.1 In-house 2-262 (263) alignment 
Range on Protein: 4258-4517
Range on HMM: 2-262/263.0
FSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGV---AGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMT
.. |...| ...... .| |.. .| .||||.|||||| |||.||      |.|||||.||| .. .|||||||||||.|.|.||.||||.....|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

ALVEGGKTKCEHYWPAG-EEPQLHGNVTVTLVGSNQTD-NFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaaTGPI
  .| ||.||..|||   .... .|...|.||  .... ..| ||| |.|||  ..|.||.||| .|.|||||.|| ... |||.|| ....    .|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

VVHCSAGVGRTGTFIAADMLMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
||||||||||||||...|.... ... .    .|.  .. ..|.||. .|||| ||.......| .|
vVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 4258-4517 1e-87 289.1 In-house 2-262 (263) alignment 
Range on Protein: 4258-4517
Range on HMM: 2-262/263.0
FSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGV---AGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMT
.. |...| ...... .| |.. .| .||||.|||||| |||.||      |.|||||.||| .. .|||||||||||.|.|.||.||||.....|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

ALVEGGKTKCEHYWPAG-EEPQLHGNVTVTLVGSNQTD-NFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaaTGPI
  .| ||.||..|||   .... .|...|.||  .... ..| ||| |.|||  ..|.||.||| .|.|||||.|| ... |||.|| ....    .|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

VVHCSAGVGRTGTFIAADMLMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
||||||||||||||...|.... ... .    .|.  .. ..|.||. .|||| ||.......| .|
vVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4258-4514 4.4e-70 230.9 In-house 7-265 (274) alignment 
Range on Protein: 4258-4514
Range on HMM: 7-265/274.0
FSDEYNNLPAMEKTRAVtaaRQARNDDKNRYRNILPYDYTRVQLKGVAG----TDYINASYIKDDHG-QKKYIATQGPLPNTIEHFWEMVWENQTSTIVM
. .|. .||.  ... .   . ...  ||||..||| . .|| |.   .    ..|||| |||  .. .| |.|||||||||.. ||.|....... |||
lekeflelPlnfdqeel...dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

MTALVEGGKTKCEHYWPAGEEP---QLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDGAATGP
.| | |  ..||..|.|  |.    . .|.| .. .. ......  |.|.|..   ||.|.|| | .| || .|... .|. |...|. ...|. | ..|
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklap

IVVHCSAGVGRTGTFIAADMLMDAIQRstaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
.|||||||.|||| |||... .  ...   .  .|| ......| .|  .|||  || ..||.. 
vvvhCsaGiGrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 4258-4514 1.7e-68 226.3 In-house 36-288 (319) alignment 
Range on Protein: 4258-4514
Range on HMM: 36-288/319.0
FSDEYNNLPAMEKTR-AVTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMM
.  |..... .       | |   .| ||||. |||..| ..|.|.   |. ..||||||...    ..||||.||||.||.. || |.|| ..||||..
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivll

TalveggKTKCEHYWPA-GEEPQLHGNVTVTLVgsNQTDNFIERTLLLEKE---GTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTN-QEDGAAtg
|      | ||  |||  ... . ...| |..|  ..|.... | . | ..      | .| . .| | |.|||.....|. |...|.  . .|.. |  
t......kdkcsqywplkivikeerfkvkvdsv..eetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra..

PIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
.|||||||||||||..|. |.|.| ...    . .||  ..  .|.||  ||| | || ... ..|
nivvhcsaGvGrtGvyivldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_PTPN14_pd Subfamily PTPN14 4258-4518 8.6e-64 210.4 In-house 25-297 (300) alignment 
Range on Protein: 4258-4518
Range on HMM: 25-297/300.0
FSDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVA--GTDYINASYIKDDHG--QKKYIATQGPLPNTIEHFWEMVWENQTSTIVMM
   ||...| ...   ...|.   | .|||....|||. .||.|.      |.||||| ||   |  ...||..||||..|.. ||.||||.... |||.
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TALVEGGKTKCEHYWPAGEEPQ---LHGNVTVTLVGSNQTDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDG----
|.  |.||.|. .|.|  |. .    .|.  ||   |...| .| ..| |.    . |||| | ||  |.||||||   . .  |..|.   ..      
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

--AATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
   .  |..|||||||||||  | .|.|. ...     . ||.  ..|..|||| |||||| || .......  ..
skeskPPvlvhCsaGvGrtGvlilsdlliatlehn...eeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN13_pd Subfamily PTPN13 4259-4518 1.4e-75 249.1 In-house 14-270 (273) alignment 
Range on Protein: 4259-4518
Range on HMM: 14-270/273.0
SDEYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGtdYINASYIKDDHGQK--KYIATQGPLPNTIEHFWEMVWENQTSTIVMMTAL
..|...|  .  .  .. .....| |||||||.|||| |||.|.. .|  |||||.||   |..  .|||.|||||.|.. || |||| ... |.|.|  
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

VEGGKTKCEHYWPAGEEPQL--HGNVTVTLVGSNQTDNFIERTLLLEKEGT--ERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQedgaATGPIVV
.|.|| ||. |||  .. .|  .. ..|.|.. .. |.|  |.| ...  .   | |.| .. .| ||||| |.|.|. ....|.  ..     .|||||
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....dagPivv

HCSAGVGRTGTFIAADMLMDAIQRSTatdYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
|||||.||.||.|. |.... |.| .    .||  .. |.||||  .|||  |||. ....| ...
hcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_CG42327_pd Subfamily CG42327 4259-4439 4.5e-33 109.2 In-house 8-193 (319) alignment 
Range on Protein: 4259-4439
Range on HMM: 8-193/319.0
SDEYNNLPameKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKD-DHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMT
 .|...||   .  | . .  .  .||.|. |..|   ||| |. ..    . |..|||..  |  .  |||.| .| ..   || .|||.|. .|| .|
aeefrdlP...qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

ALVEGGKTKCEHYWPA---GEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYlAWTDHGVPESTAPLVGLLRQVKVT
 | | |  .| .|.|.   ... .|.|.. ||| | .  |...  |||| .      | .||| |  | . .|| . |.|. .| .|. .
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_PTPN3_pd Subfamily PTPN3 4261-4519 6.8e-74 243.3 In-house 20-277 (280) alignment 
Range on Protein: 4261-4519
Range on HMM: 20-277/280.0
EYNNLPAMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGtDYINASYIKDDHGQ----KKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTAL
....|   .. .|..|||...| .|||||.||||| |||.||     |||||.|.. .       ..||||||||..| ..||.||||...|.|||.| |
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl

VEGGKTKCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNqedGAATGPIVVHC
|| |..|| .|||  |. . .|. .|..  ...| ... | |.|...    ||.... |||||.|||||...| .. ....|. .     ... |.||||
verGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr...sgkeePvvvhC

SAGVGRTGTFIAADMLMDAIQRSTATDYIDVagtIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
|||.|||| .|. .. .  |... .   .|.   . ..|.||| ||||  || ..  ..| . ||
saGigrtGvlilletalalieaaepvypldi...vrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 4267-4517 1.9e-51 169.7 In-house 18-295 (297) alignment 
Range on Protein: 4267-4517
Range on HMM: 18-295/297.0
AMEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLKGV-AGTDYINASYIK--DDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTK
   .. . ..|..     |||||.|| .| |||.|..| ...||||| |.   |.. . ||| .|||| .|.. ||..|.|..  .|||.. | |.|. |
deargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdk

CEHYWPAGEE-PQLHGNVTVTLVGSnQTDNF---IERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPL-----------------VGLLR--------
|  |||  ..  .  |.| |  . |  .|.|   |   | |     .| |.| |.|.| |||||     |                 ..|.         
capywpsvvqerlkagdvvveflss.tsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvfl

QVKvTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATdyiDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
|.. . . .     ...|||||||||.|  . .|.... ...       |||  . ..||||| ||||| |. .|.  ||  .
qle.slraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkrip...dvaailsilreqrarlvqtleqfellydavlkkl
subfamily_PTPN12_pd Subfamily PTPN12 4268-4519 8.3e-79 259.5 In-house 26-279 (290) alignment 
Range on Protein: 4268-4519
Range on HMM: 26-279/290.0
MEKTRAVTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKC
.||.   .|... .|  ||||..|||||..||.|.   .. | |||||..||  .|...|||.|||||.|.. || |.|| ... .||.  .|| ||.||
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

EHYWPAGEEPQL-HGNVTVTLVGSNQTD-NFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQedgAATGPIVVHCSAGVGRTG
|.|||   | .| .|...|||   ...| .|. ||| .|.....|.|. ..| || |||||.|. .|. |...|. ...   .   |.||||||||||||
erYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtG

TFIAADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIEE
| || |.  ..... . .. .||   ....|.||| ||||  || .....|..|...
tiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 4271-4517 3.4e-40 132.6 In-house 42-289 (305) alignment 
Range on Protein: 4271-4517
Range on HMM: 42-289/305.0
TRAVTAARQA--RNDDKNRYRNILPYDYTRVQLKGVAGTDYINASYIKDD-HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHY
|...  | |.   .  ||||...   | . |.|.  . .||| | |.      .|..|..|||| .||..|| || .|.   |||.   || || || .|
tqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqy

WPA--GEEPQLHGNVTVTLV-GSN--QTDNFIERTLLL-EK-EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKvtnqedGaATGPIVVHCSAGVGR
|||  ||  .|.. . |  | ||.  . |. |. |||      . . .| | |.  | | |||      . ||  ..      | .  |||||||||.||
wpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......g.skvpivvhcsagigr

TGTFIAADMLMDAIQRSTATDyiDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
||| .| . ... |          .   .  .|.|||  .|.  ||...|| .|  .
tgtivaieyilekiaenkpcp..pmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_egg_pd Subfamily egg 4271-4515 6e-31 102.2 In-house 29-268 (307) alignment 
Range on Protein: 4271-4515
Range on HMM: 29-268/307.0
TRAVTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGgkTKCEHY
  ..| | .. | .| | . .   |..||.|.   |    |.| | ..| .    ..| .| || || . || ||....   |||.|. .|    .||.|
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPAGE-EPQLH--GNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLvGLLRQVKvtnQedgaATGPIVVHCSAGVGRTGTF
||  | ..     |.. .. .. ... . . |   |   |...   . ..  .  . . .   ||  .||...   .    .. |.||..  || ...|.
wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvyspl.rvlrklr...n....lskpvvvqdilGvskaatl

IAADMLMDAIQRSTATDYIdVAGTIAKIREQRALLVQTLYQYIYLHRTVLS
.|... .  . |   | .. |  ..  .| .| | |..  .|....| || 
vaieiallsllrGpitksl.vlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_eak_pd Subfamily eak 4271-4517 4.4e-20 66.3 In-house 41-305 (332) alignment 
Range on Protein: 4271-4517
Range on HMM: 41-305/332.0
TRAVTAARQARNDDKNrYRNILPYDYTRVQLKGV--AGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYW
 .... ...  . ..|   .|.|||.  |.|         ||||| ..  .  .||| |  .  . .  ||.|| |... .||..   || .  | . |.
llsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PAGE-EPQLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAP--L------VGLLRQVKVTNQ----------EDGAATGP
|    |   .| . |.     . ...  | | |.|      | ||..  ||.  .|       |      || |  . . ..              .  |
pdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfap

iVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYiDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
 .. .. |  |.|.|.  |.|.  |.      |  |   | |....|   | .  |. ...  ||  .
.iiqsarGsaraGvfvvidllirlidnkkknly.svedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_PTPN1_pd Subfamily PTPN1 4272-4510 1.8e-67 222.1 In-house 22-264 (290) alignment 
Range on Protein: 4272-4510
Range on HMM: 22-264/290.0
RAVTAARQARNDDKNRYRNILPYDYTRVQLKGvAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG
  ...|.. .| ..||||.. |||..|..|.  | .|||||| .. .. ...|| ||||||||..|||.||||... ..||.  .|| ...|| .||| |
fptreaklpenrnlnryrdvspydhsrikler.adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

EE-PQLH---GNVTVTLVGSNQTDNFIERTLLLEKE--GTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEdGAATGPIVVHCSAGVGRTGTFI
||  .|     ...|.|.  ....... |.| ||.      |...|. |..|.| ||||| | .. .| .|. .        || |.|||||.||.|||.
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsl.ssdvGpavihcsaGiGrsGtfc

AADMLMDAIQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLH
 .| ..  |...  .. .|.  .. ..|..|  |.||  |  . .
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 4272-4510 2.7e-15 50.8 In-house 37-272 (303) alignment 
Range on Protein: 4272-4510
Range on HMM: 37-272/303.0
RAVTAARQARNDDKNRYRNILPYDYTRVQLkgvAGTDYINASYIKDDhGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG
  |.  .  .| ||||. ...  |...|.|   . . || |||.. |  .|| | || ||. |   ||.|. |..   .... .  |  |   .  .|  
psvsknqfvknmdknrfvdvicldhskvkl...sdssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

EEPqLHGNVTVTLVGSNQTDNFIER---TLLLEKEGTERTVTH-YQYLAWTDHGVPESTA-PLVGLLRQVKVTNQEDGAATgPIVVHCSAGVGRTGTFIA
..  |. .  .  ||  .  .. .     .|   .|. ..  | ..| ||    .|  ..  .|  . |..   .    .| | |    .|.||.|||  
qdf.lkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfal

ADMLMDAIQRSTATdyIDVAGTIAKIREQRALLVQTLYQYIYLH
 .    ...   |.  .|.   . ..|. |   || | |. ...
fetahlslhseqas..ldlvkclenvrngrlhavqnlsqfsvvy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4273-4518 3e-71 234.6 In-house 11-265 (270) alignment 
Range on Protein: 4273-4518
Range on HMM: 11-265/270.0
AVTAARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIK-DDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYW
  .   .||.   |||..|||   |||.|. .     | |||| |..  |. .|||||..||||.|...|| |.||.....|||.| |.| |..||| ||
esdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYW

PAGEEP---QLHGNVTVTLVGSNQTDNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTA------PLVGLLRQVKVTNQEDGAATgPIVVHCSAGVG
||  .      .|...|. . ..... .| . | ||..|.|| ..|..| .| |||||...        |. .||.|. ...|   |. |..||||||||
paepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvg

RTGTFIAADMLMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLIE
||||.|| |. . ......    .||.  |...|..|  |||.  || .|...|.  .|
RtGtlialDiavrlLeetkk...vdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 4273-4513 2.6e-57 188.8 In-house 29-273 (287) alignment 
Range on Protein: 4273-4513
Range on HMM: 29-273/287.0
AVTAARQARNDDKNRYRNILPYDYTRVQL--KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPA
   || .  .  |||| ..||.| ||| |  .|  |.||||| |.   . ....||.|||.. |.  || .|.|........||  || .. || .||| 
tfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPe

GEEPQLHGNVTVTLVGS-NQTDNFIERTL-LLEKEGTE-RTVTHYQYLAWTDHGVPESTAPLVGLLRQV--KVTNQEDGAATGPIVVHCSAGVGRTGTFI
 | | . |  .|.|.   ..  ..  |.| |.. |. | | |  ...|.| |.... ..  |. .  .|  ..  . |.. .||.|||...|.||.|...
revPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGill

AADMLMdaiQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
|  .|.   .|   .  .||| .....||.|| |||.  |. .|  ..
atlvlv...srledlGrvdvaavvirlreyraalvqavvqlrllyeal
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 4273-4364 3.1e-07 24.2 In-house 25-118 (332) alignment 
Range on Protein: 4273-4364
Range on HMM: 25-118/332.0
AVTAARQARNDDKNRYRNILPYDYTRVQLKGVAGT-DYINASYIKDDHGQKKYIATQGPLPNTIEH-FWEMVWENQTSTIVMMTALVEGGKTKC
  |  .   | | ||   .  .|..||.|    |  |. |||..     .  || .| |. .  |. || || | . | |...  . |  | |.
pntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 4274-4514 1.8e-67 222.9 In-house 17-252 (284) alignment 
Range on Protein: 4274-4514
Range on HMM: 17-252/284.0
VTAARQARNDDKNRYRNILPYDYTRVQLK---GVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTalveggKTKCEHYWPA
 | |   .| ||||. .||..| ..|.|.   |. ..||||||.|.    ..|||||||||.||.. || |.|| ..||||..|      | ||  ||| 
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

-GEEPQLHGNVTVTLVgsNQTDNFIERTLLLEKEG---TERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDGaATGPIVVHCSAGVGRTGTFIA
 ... . ...| |..|  ....... | . | ..|     |... . .| | |.|||.....|. |...|.  ..       .|||||||||||||..|.
kivikeerfkvkvdsv..eeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsken.hranivvhcsagvgrtgvyiv

ADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
 |.|.| ...    . .||  .. ..|.||  ||| | || ... ..|
ldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysall
0049772 (Phosphotyrosine protein) phosphatases II 4274-4516 3.2e-43 144.0 In-house 38-279 (314) alignment 
Range on Protein: 4274-4516
Range on HMM: 38-279/314.0
VTAARQARNDDKNRYRNILPYDyTRVQLKG--VAGTDYINASYIKDDhgqKKYIATQGPLPNTIEHF----------WEMV--WENQTSTIVM-------
...|.. .| ||||| .|||.| .||.|.|  | |.|||||||..     .|.|||||||..|.. |          |.||  ..... .|||       
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------MTALVEGGktkceHYWPAGEEPQLHgnvtvtlvgsnqtdnfierTLLLEKEGTERTVTHYQYLAWTDHGVPeSTAPlvgLLRQVKV
               . | ..|      ...| . ..|.                   . | ..|  ||.. .| .. ..|...| ...    ... ...
delsrLdaAlgKtpllildgng.....neptaadlellk...................eelydpelferlgikylripvpDgsap.lled...fdeflef

TNQEdgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQrstatdyIDVAGTIAKIREQRA-----LLVQTLYQYIYLHRTVLSL
 ..    . ||..|||.||.||||||..|..|| . .       .... ... .|..|       ....| ||.. .. .| .
ieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg.......vsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 4274-4517 9.4e-38 124.6 In-house 42-282 (301) alignment 
Range on Protein: 4274-4517
Range on HMM: 42-282/301.0
VTAARQARNDDKNRYRNILPYDYTRVQLKGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEE
.| .    ..||.|| ..     | |..        | | .|. .   ...|||||||.|| | || |.   .  .|||..  ||  ..|||.| |   .
itesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

PQLH-GNVTVTLVGSN--QTDNFIERTLLLEKE---GTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQedgaatgPIVVHCSAGVGRTGTFIAA
 .|. |  ..... ..    .. ..||| .|      . ||||||||  |||.|||.| | |  |.  || ...       |||||||||.||. .||..
ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigt

DMLMDAIQrstATDYIDVAGTIAKIREQRALLVQTLYQYIYLH-RTVLSLI
..|  ...   |   |... .....||.|   |||  |  ..   ||  ||
eylareve...adptieltealkhlrehrwngvqtnsqlywmtlGtvyrli
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 4274-4421 2.3e-14 47.6 In-house 88-234 (244) alignment 
Range on Protein: 4274-4421
Range on HMM: 88-234/244.0
VTAARQARNDDKNRYRNILPYDYTRVQL-KGVAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEggktkCEHYWPAGE
.  | .  |  |||    ||.|. || | ||  |  |||||..       .|| || || .|   || |. |     .|.. .. |      . |||  |
mkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdse

EPQL-HGNVTVTLVGSNQTDNFIERTLLLEKEGTE--RTVTHYQYLAWTDHG
  .    ..||||   ..  |     | .| .  |  ...| .|   |   |
plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 4274-4352 9.5e-11 35.8 In-house 29-115 (347) alignment 
Range on Protein: 4274-4352
Range on HMM: 29-115/347.0
VTAARQARNDDKNRYRNILPYDYTRVQLKG--------VAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVM
.|..   .. .||| ..    | ||| |               |||||.|| |  .|.|| || |||.|.  || ||   . . .| 
ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
0040439 (Phosphotyrosine protein) phosphatases II 4276-4517 7.6e-78 256.8 In-house 5-246 (249) alignment 
Range on Protein: 4276-4517
Range on HMM: 5-246/249.0
AARQARNDDKNRYRNILPYDYTRVQLKG---VAGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgE
 |.   | |||||..|||||..||.|.    . ..||||||||.  . ....||||||||.|.|.||.|.||.. ..|||.| ||| |. ||..|||  .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.g

EPQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgAATGPIVVHCSAGVGRTGTFIAADML
... .|..||||.  .. |... ||| |.  ..|..|||.|.||. | |||||.|...|. ....|.  ..|.    ||..||||||||||||||||...
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylm

MDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
.. ...      .|.  .....|.||   ||.. ||..|.. .| |.
leqlekelg...vdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 4276-4516 2.1e-67 222.0 In-house 3-241 (250) alignment 
Range on Protein: 4276-4516
Range on HMM: 3-241/250.0
AARQARNDDKNRYRNILPYDYTRVQLKGVA---GTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTkCEHYWPAgE
 |.. .| .|||| .|...| .|| |. .     .||||||...  ...| .|||||||..|||.|| ||.|....||||.| |.| .|| ...|||. |
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.e

EPQLHGNVTVTLVGSNQTDNFIERTLLLEK--EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEdgAATGPIVVHCSAGVGRTGTFIAADML
... .|.|||.|  ...  ... |.| | |  .  ||.| ......| | |||| .   ..||..|. ..|.  | ..|..|.|||||||.|.||| | .
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq..agnaPvivqCsaGvgrsGafiaidav

MDAIQRSTatdYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
.. ....     .||   | ..|..|   |..| ||..... .|  
lerlkkek...vvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4276-4514 3.3e-51 168.7 In-house 2-238 (239) alignment 
Range on Protein: 4276-4514
Range on HMM: 2-238/239.0
AARQARNDDKNRYRNILPYDYTRVQLKGVA---GTDYINASYIKDDHG-QKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG
||..  |  |||| ||. ||..|| |. ..    .|||||||..|  |  | |||||| .  .   || |.|...   |||.| |.|| | || .|||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

EepQLHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRqvKVTNQEDgAATGPIVVHCSAGVGRTGTFIAADM
     . |. |||  ..   ..| ||... . |   || | .|..  | |.|||. .. ..|| |  |.|..     . | |.||||||||||.|.  | 
t..skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr..kitkdsl.pgarpwvihcsagvgrtgaflvida

LMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
..   ..  .   .|.   .  |||.|  .|||  ||...| .||
mlrqakkqkt...vdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4276-4514 4e-51 168.5 In-house 1-237 (239) alignment 
Range on Protein: 4276-4514
Range on HMM: 1-237/239.0
AARQARNDDKNRYRNILPYDYTRVQLKGVA---GTDYINASYIKDDHG-QKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG
||..  |  |||| ||. ||..|| |. ..    .|||||||..|  |  | |||||| .  .   || |.|...   |||.| |.|| | || .|||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

EepQLHGNVTVTLVGSNQTDNFIERTLLLEKEG--TERTVTHYQYLAWTDHGVPESTAPLVGLLRqvKVTNQEDgAATGPIVVHCSAGVGRTGTFIAADM
     . |. |||  ..   ..| ||... . |   || | .|..  | |.|||. .. ..|| |  |.|..     . | |.||||||||||.|.  | 
t..skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr..kitkdsl.pgarpwvihcsagvgrtgaflvida

LMDAIQRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
..   ..  .   .|.   .  |||.|  .|||  ||...| .||
mlrqakkqkt...vdifnyvkairedrphmvqtseqyvfihlavl
0042113 (Phosphotyrosine protein) phosphatases II 4277-4517 4e-76 250.9 In-house 4-243 (245) alignment 
Range on Protein: 4277-4517
Range on HMM: 4-243/245.0
ARQARNDDKNRYRNILPYDYTRVQLKGVAG---TDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgEE
|.   | |||||..|||||.|||.|. . |   .|||||||.. ..  .|.||||||||.|.|.||.|.||.. .||||.| ..| |. ||..|||  .|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

PQLHGNVTVTLVGSNQTDNFIERTLLLE--KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEdgAATGPIVVHCSAGVGRTGTFIAADMLM
.. .|..||||.. .. |... ||| ..  ... .|.|.||.|| | |||||.... |. .|. |.   .|   . ||..||||||||||||||||....
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylml

DAIQRStatDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
. ...      ...  .....|.||   |||. ||..|.. .| |.
eqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 4277-4516 3.6e-74 244.7 In-house 5-241 (243) alignment 
Range on Protein: 4277-4516
Range on HMM: 5-241/243.0
ARQARNDDKNRYRNILPYDYTRVQLKGvagTDYINASYIKDDhgqKKYIATQGPLPNTIEH----FWEMVWENQTSTIVMMTALVEGGKTKCEHYWPagE
|.   | .||||..|||||..|| |.|   .|||||..|.     ...||||||||.|.|.    ||.|.||.....|||.| ||| |. ||..|||  .
allpenlsknrysdilpydhsrvkleg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..g

-EpqLHGNVTVTLVGSNQTDNFIERTLLLEK---EGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQE-----DGAATGPIVVHCSAGVGRTGT
 .   .|..||||......|... ||||||    .. .|.|.||.||.| |||||.|...|. .|..|.   .|          ||..||||||||||||
ev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

FIAADMLMDAIqrstatDyIDVAGTIAKIREQRAL-LVQTLYQYIYLHRTVLSL
.|||..... .      . .|.  .....||||    |||. ||..|.. .| |
liaaylmllll......g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 4278-4513 8.1e-33 108.6 In-house 31-266 (285) alignment 
Range on Protein: 4278-4513
Range on HMM: 31-266/285.0
RQARNDDKNRYRNILPYDYTRVQLKGVaGTDYINASYIKD-DHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAG-EEPQ
    | | ||| ..   . ||| ||     ||| ||...   . |  ||.||||||.|.  || |..... . ..|. .|.|||  ||  |.|    |  
ayeanpdlnryadvrcieetrvvlknh.drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

LHGNVTVTLVGSNQ--TDNFIERTLLL-EKE--GTE-RTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaatGPIVVHCSAGVGRTGTFIAADM
  |.  .||   ..      |  .| . . |   .|   . | |   | |.  || . |.. | . ||  | ..     ||.|||||||||| ||.  | 
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke....kpicvhcsagvgrtatfvgidy

LMDAIQRSTATDYIDVagtIAKIREQRALLVQTLYQYIYLHRTV
    |      . .|.   . ..|  |   ||.  |...|.  .
atirimenpniemldi...vremramrfqavqshmqflflyvvl
subfamily_ptpA1_pd Subfamily ptpA1 4279-4474 6.8e-47 155.1 In-house 44-256 (418) alignment 
Range on Protein: 4279-4474
Range on HMM: 44-256/418.0
QARNDDKNRYRNILPYDYTRVQLKGV---AGTDYINASYIkDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPA---GE
. .|  |||| |||| ..|||||| .    |.||||| || |    |..|.|||||||||  || |||||.   |||..   |  . ||..|||    ||
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi.dgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

EPQLHGN-------VTVTLVGSNQT--DNFIERTLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKV-TNQE--DGAATGPIVVHCSAGVGR
.  ..||        .| ||   |    . | | . |  ||  | .|.|||  | || .|. | |.  ||. .    ||         ||.|||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGTFIAADMLMDAI
|||| .| ..|  .
tgtfctavimmkkl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 4281-4514 3.8e-60 198.1 In-house 2-236 (237) alignment 
Range on Protein: 4281-4514
Range on HMM: 2-236/237.0
RNDDKNRYRNILPYDYTRVQLKGVA-GTDYINASYIKDDHG-QKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLHG
.|  |||| ||  ||..|| |||   |.|||||.|.|.  |  |||||.|||| .. . ||.|||... | |||.| |.|| . || .|||  ..|. .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

NVTVTLVGSNQTDNFIERTLLLEKEGTERT---VTHYQYLAWTDHGVPESTAPLVGLlRQVKVTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDaiq
 .||.|   ..  ..  |.||| |..| .    .  ||. .| |.|||. || |. . |.  . . .  . .|| ..|||||||||| |.  | ..    
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrf.rkniinrsphvsesgpwiihcsagvgrtgiflvidamlr...

RSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
..     .|.   .  | |.|  ..||  ||...|.|.|
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 4281-4517 1.5e-32 107.6 In-house 42-276 (312) alignment 
Range on Protein: 4281-4517
Range on HMM: 42-276/312.0
RNDDKNRYRNILPYDYTRVQLKGVAgTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPA------GEEP
.  | ||| ||  .|  |  | |     || | ..|     .....||||| ||. |||...    ...|......|| |  || .|          |. 
kfkdlnrypniqcwdrgrftlagde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

QLHG-NVTVTLVGSNQTDNFIERTL--LLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQedgaatgPIVVHCSAGVGRTGTFIAADMLM
...   .|   .| .  |.   | |  ..   | |  . |||. .| |||.|.|      ||  ||  ..       |.. |||||||||||..  . ..
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.......pviahcsagvgrtgtlaliesmi

DAIQRSTATdyiDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
 |..        .|  .   .| .||  |... ||.|  |.|| ..
aalrhprkq...nvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
Y_phosphatase Protein-tyrosine phosphatase 4282-4514 8.8e-80 262.9 Pfam-A 1-234 (235) alignment 
Range on Protein: 4282-4514
Range on HMM: 1-234/235.0
NDDKNRYRNILPYDYTRVQLKGVAG-TDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWP-AGEEPQLHGN
| .||||..||||| |||.|||  | .|||||.|.|  . .||.|||||||..|||.||.|||......|||.| |.| |..||..||| . ||.. .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VTVTLV-GSN-QTDNFIERTLLLEKEGTER---TVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNqedGAATGPIVVHCSAGVGRTGTFIAADMLMDAI
..|.|.  .. ...... |.| |.|...|.   .|....| .|.|||||||. .|. |.|.|. ..    | .||.||||||||||||||.|.|.|.. .
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

QRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
..      .||  .. ..|.||. .||.| |||.|....|
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 4282-4514 8.8e-80 262.9 In-house 1-234 (235) alignment 
Range on Protein: 4282-4514
Range on HMM: 1-234/235.0
NDDKNRYRNILPYDYTRVQLKGVAG-TDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWP-AGEEPQLHGN
| .||||..||||| |||.|||  | .|||||.|.|  . .||.|||||||..|||.||.|||......|||.| |.| |..||..||| . ||.. .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VTVTLV-GSN-QTDNFIERTLLLEKEGTER---TVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNqedGAATGPIVVHCSAGVGRTGTFIAADMLMDAI
..|.|.  .. ...... |.| |.|...|.   .|....| .|.|||||||. .|. |.|.|. ..    | .||.||||||||||||||.|.|.|.. .
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

QRSTAtdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
..      .||  .. ..|.||. .||.| |||.|....|
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 4282-4516 3.1e-49 162.4 In-house 1-170 (182) alignment 
Range on Protein: 4282-4516
Range on HMM: 1-170/182.0
NDDKNRYRNILPYDYTRvqlkgvaGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTalveggktkCEHYWPageepqlhgnvt
| |||||..|||||..|       . |||||...  .. ....|||||||..|...|..|..|.. .|||..|         .|.|||            
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp............

vtlvgsnqtdnfiertlllekEGTERTVTHYQYLAWTDHGVPEsTAPLVGLLRQVKVtnqedgaATGPIVVHCSAGVGRTGTFIAADMLMDAiqrstatd
                     |  ||....|.|| | |||||. .  |. ....|.          ||..||||||||||||..||....          
.....................ellerlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl........

YIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
 ...  ... .|..|   |.|. ||..|.. .| |
gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4284-4380 1.2e-25 85.0 In-house 49-162 (350) alignment 
Range on Protein: 4284-4380
Range on HMM: 49-162/350.0
DKNRYRNILPYDYTRVQLK-----------GVAGTDYINASYIKDD------HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEH
 ||||.|||||. .||.||            . . |||||.|.|          . ||||||.|||.|.. |.... .|.   |...|..|| .  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPAGEEPQLHGNV
||. |.  . .  .
YWqegsydditvkl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4284-4372 1.7e-13 44.7 In-house 50-157 (349) alignment 
Range on Protein: 4284-4372
Range on HMM: 50-157/349.0
DKNRYRNILPYDYTRVQLKG-----------------VAGTDYINASYIKDD--HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKC
 ||||..||||...||.||                      ||||| |.|      .||||||| ||| |.. |....  |.   .. ..   | .  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

EHYWPAGE
. ||  ..
diywqels
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 4286-4514 4.6e-26 86.6 In-house 23-256 (290) alignment 
Range on Protein: 4286-4514
Range on HMM: 23-256/290.0
NRYRNILpYDYTRVQLKGVA---GTDYINASYIKDDHGQkKYIATQGPLPNT-------IEHFWEMVWENQTSTIVMMTALVEGGKT----KCEHYWPAG
.|... |    ||| |||       ||| |....  .|. . |.|| |. ..       ||.|| |. . .   .||.    |  .      |..| |  
qRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

EEPQLH-GNVTVTLVGSNQTDNFIERTLLLEKE-GTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKvTNqedgaaTGPIVVHCSAGVGRTGTFIAADM
.. .|  ...||      . |....|.|... . . | ||||...  |..  |.|.|  |. |...|| ..      . |..|||  |. |  .. | ..
vgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as......ktpvivHcvdGiSrsAalaaiil

LMDAIQRStaTDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVL
 .  |  .  .. . ..  . ..|.||||....  .. .    ..
gyQkiaet..sgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 4292-4421 4.8e-10 33.9 In-house 3-125 (130) alignment 
Range on Protein: 4292-4421
Range on HMM: 3-125/130.0
LPYDYTRVQlkgvaGTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEggktkCEHYWPAGEEPQ-LHGNVTVTLVGSNQT
|.....|.|     | .|||||..      ..|. || || .|  .|| |. |     .|.. .. |      . |||  |  .    ...|||   .. 
lefevsrlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrdef

DNFIERTLLLEKEGTE--RTVTHYQYLAWTDHG
.|     |  |..  |  ...| .|   |   |
knikasnleiesdlneshqaltmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 4298-4515 3.6e-33 110.1 In-house 6-169 (178) alignment 
Range on Protein: 4298-4515
Range on HMM: 6-169/178.0
RVQL---KGVAGTDYINASYIKDDhgqkKYIATQGPlpntiEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEpqlhgnvtvtlvgsnqtdnfi
|| |    |. ..||||||.| ..     |.....|     ....|...|.  ..||..|  .|.|. || .||| ...                     
rvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.....................

ertlllekegtertvTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDGaatGPIVVHCSAGVGRTGTFIAADMLMDAiqrstatdYIDVAGTIAKIRE
                .|... . |||||.... .  ... ..   .|.|   ||..|||||||||.||..||....           ...   |. .||
...............iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaielvre

QRAlLVQTLYQYIYLHRTVLS
.|   |..  |. .|..  | 
rRp.ivpnpgqlrqLyefelr
0036282 (Phosphotyrosine protein) phosphatases II 4306-4510 4.4e-44 145.6 In-house 1-163 (174) alignment 
Range on Protein: 4306-4510
Range on HMM: 1-163/174.0
GTDYINASYIKDDHGQKKYIATQGPLPntiehFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAgeepqlhgnvtvtlvgsnqtdnfiertlllEKEGT
|.||||||...  .  ...||.||||.     ||||..|.. .|.||.. ..| |..|| .|||                                .|  
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

ERTVTHYQYLAWTDHGVPESTApLVGLLRQVKVTNQEdgAATGPIVVHCSAGVGRTGTFIAADMLMDAIQrstaTDYIDVAGTIAKIREQRALLVQTLYQ
||.. .|.|| | |||||...  |  ....|.   .|     ||..||||||||||||..||....  .     ....|.  .....| ||   |||  |
erlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQ

YIYLH
|..|.
yrfly
0043147 (Phosphotyrosine protein) phosphatases II 4306-4510 4.6e-42 139.0 In-house 4-154 (172) alignment 
Range on Protein: 4306-4510
Range on HMM: 4-154/172.0
GTDYINASYIKDDHGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALveggktkcehywpageepqlhgnvtvtlvgsnqtdnfiertlLLEKEGT
|.|||||||..  .  ...|||||||.||...||.|..|.. ..||..| |                                          |. .|. 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpell

ERTVTHYQYLAWTDHGVPeSTAPLVGLLRQVKVTNQED-GaatGPIVVHCSAGVGRTGTFIAADMLMdaiqrstatDYIDVAGTIAKIREQRALLVQTLY
||.. .|.|| | ||||| ... |  .|....   ... |   ||..||||||||||||..||....           ...  ..| .||.|   ||.  
erlgiqylylpwpDhgvp.llellleflefidellalspg...gpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnps

QYIYLH
||..|.
qyrfly
0046846 (Phosphotyrosine protein) phosphatases II 4306-4516 2e-41 137.0 In-house 11-172 (176) alignment 
Range on Protein: 4306-4516
Range on HMM: 11-172/176.0
GTDYINASYIKDDhgqkKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQLhgnvtvtlvgsnqtdnfiertlllekegt
. |||||..|  .    ..||||||||.|...|.||..|.. ...|..| .|| |. || .|||  |....                             
dldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

ertvtHYQYLAWTDHGVPEStAPLVGLLRQVKVTNQEDgaatGPIVVHCSAGVGRTGTFIAADMLMDaiqrstaTDYIDVAGTIAKIREQRA-LLVQTLY
     .|..| | |||||.. . |  ||....   .|.    ||..||||||.|||||..||..|.           ..|  ..|..||||    |||  
.....qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllel.......ekglsveealalvreqRplgavqtpe

QYIYLHRTVLSL
|| .|.. .| |
Qyrflyefelll
0051429 (Phosphotyrosine protein) phosphatases II 4307-4517 9.4e-48 158.5 In-house 4-225 (272) alignment 
Range on Protein: 4307-4517
Range on HMM: 4-225/272.0
TDYINASYIKDDHG---QKKYIATQGPLPNTIEHFWEMvWENQTSTIVMMTALVEGGKTKCEHYWP-----------AGEEPQLHGNVTVTLVGSNQTDN
..||||....  ..    .......||||.|...|| . .|.. .|||... ..| |. ||. |||            .... |.|...|||.   ....
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FIERTLLLE---KEGTERTVTHYQYLAWTDHGVPESTapLVGLLRQVKVtnqedgaaTGPIVVHCSAGVGRTGTFIAADMLMdaiQRSTATDYID-----
.| |.|||.   . |. |.|.|..|..| |||||...  |. ||...           ||..||||||..||||..|...|.   .. .... .|     
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvalllll...lgvsletivddYllt

---VAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
   ........|.||.  |||  ||..|.. .| |.
nlyleeaveelraqrpgavqteeqylflyeallell
0051082 (Phosphotyrosine protein) phosphatases II 4307-4512 1.1e-31 104.8 In-house 3-148 (151) alignment 
Range on Protein: 4307-4512
Range on HMM: 3-148/151.0
TDYINASYIKDDhgqkkYIATQGPLPntieHFWEMVWENQTSTIVMMTALVEGGktKCEHYWPAGEepqlhgnvtvtlvgsnqtdnfiertlllekegte
.||||.||. .      .....|||.    .|.|...|.. .|||... ..| |  .| .|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

RTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVtnqedgAATGPIVVHCSAGVGRTGTFIAADMLMdaIQrstatdyIDVAGTIAKIREQRALLVQTLYQY
..|.|...| |.|.|.|.|.. .. .|...           ||..||||||.|||||..|.....   .       .... ... .|..|  .||.  |.
ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleealeeyrlkrpgvvqpnqqf

IYLHRT
..... 
lfqlfa
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 4318-4510 1.5e-16 54.7 In-house 85-281 (302) alignment 
Range on Protein: 4318-4510
Range on HMM: 85-281/302.0
DHGQKKYIATQ--GPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEPQL-HGNVTVTLVGSN-QTDNFIERT----------LLLEKE
   .|. .. .   |  .|.| .| .. . ... .| ....||... || .|.    . .|  |. ||. |  . . ..| ..               |.
Gtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk

GTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEdgaatgpIVVHCSAGVGRTGTFIAADMLMDAIQRSTATDYIDVagtIAKIREQRALLVQTL
 ...||   .. || ||| |. . . . .|.  .   ..       ..||||||||||||..|    ..  ..   || ...   .  .|. |   ||. 
kvkktvdilafsawpdhGapkeaytaldilkfcesykkn.......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsi...vlpvrqcryGavqde

YQYIYLH
 | ||| 
qqliyll
0049260 (Phosphotyrosine protein) phosphatases II 4319-4510 2.3e-39 129.9 In-house 6-143 (152) alignment 
Range on Protein: 4319-4510
Range on HMM: 6-143/152.0
HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWpageepqlhgnvtvtlvgsnqtdnfiertlllekegtertvtHYQYLAWT
. ....||||||.|||...||.|..|.. .||||.| |.| || |||.|.                                          .|..| | 
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwp

DHGVPESTAPLVGLLRQVKVTNQEDGaatGPIVVHCSAGVGRTGTFIAADMLMdaiqrstatDYIDVAGTIAKIREQRALLVQTLYQYIYLH
|||||...  |  ||. ..  ....|   ||..||||||||||||..||....           ...  ..| .||.|   |..  |...|.
Dhgvpdlsqlllflllfieklaldkg...gpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 4319-4509 1.5e-23 78.0 In-house 2-196 (199) alignment 
Range on Protein: 4319-4509
Range on HMM: 2-196/199.0
HGQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEP-QLHGNVTVTLVGSNQTDNFIERTLLLEKEGT----ERTVTHYQ
.||..||||| || .|.  ||.||||  .  |||.       ..    |||. |     .|...||        ..   .|.| .. |     | ..|||
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YLAWTDHGVPEsTAPLVGLLR-QVKVTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStATDYIDVAGTIAKIREQRALLVQTLYQYIYL
. .| ..  |.  | .||..    .|... .     |..|||| | | || |.| |. . . . |  |  .|.     ..|. |  .. .| .| ..
ftswkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 4320-4509 2.1e-23 77.5 In-house 2-195 (198) alignment 
Range on Protein: 4320-4509
Range on HMM: 2-195/198.0
GQKKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGEEP-QLHGNVTVTLVGSNQTDNFIERTLLLEKEGT----ERTVTHYQY
||..||||| || .|.  ||.||||  .  |||.       ..    |||. |     .|...||        ..   .|.| .. |     | ..|||.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

LAWTDHGVPEsTAPLVGLLR-QVKVTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStATDYIDVAGTIAKIREQRALLVQTLYQYIYL
 .| ..  |.  | .||..    .|... .     |..|||| | | || |.| |. . . . |  |  .|.     ..|. |  .. .| .| ..
tswkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 4322-4401 9e-09 29.1 In-house 236-312 (440) alignment 
Range on Protein: 4322-4401
Range on HMM: 236-312/440.0
KKYIATQGPLPNTIEHFWEMVWENQTSTIVMMTALVEggKTkCEHYWPAGEEPQLHGNVTVTLVGSNQTDNFIERTLLLE
. .|||| ||  |.  || .| . . |||.|.  | .  || |  |||        |  ||   ||.. .    ||| | 
nafiatqmpldstvldfwrlvhdyristiimlnqlnd..kt.csiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 4326-4516 1.2e-23 78.6 In-house 39-220 (255) alignment 
Range on Protein: 4326-4516
Range on HMM: 39-220/255.0
AtqgplpnTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGE-EPQLHGNVTVTLVGsnQTDNFIERTLL----LEKEGTERTVTHYQYLAWTDH
        |...|....  ..|...||.. . | |. ||..|.|    | .   .|.||      . . . |||     | .    .||.||.|  | ..
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiek

GVPESTAPLVGLLRQVKVTNqedgaatgPIVVHCSAGVGRTGTFIAADMLMDAIQ---RSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSL
  || .  .  .|. |. .         ..|||||.|.||. .|. |...   .    . | |  .|    . ..|..|.  ..|  |  .   .|| |
naPelareilnilkvvrdsk........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_hpo-7_pd Subfamily hpo-7 4326-4517 1.2e-20 68.5 In-house 42-227 (263) alignment 
Range on Protein: 4326-4517
Range on HMM: 42-227/263.0
AtqgpLPNTIEHFWEMVWENQTSTIVMMTALVEGGKTKCEHYWPAGE-EPQLHGNVTVTLVGSNQtdNFIERTL----LLEKEGTERTVTHYQYLAWTDH
     | .||. |....  ..|...||..   | |. ||..|.|    | |   ||.|.   . .  . . .||     |..  . .||.||.|  | ..
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiek

GVPESTAPLVGLLRQVKVTnQedgaatgPIVVHCSAGVGRTGTFIAADMLMDAIQ---RSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTVLSLI
  || .   . .|. ..   .       ..|||||.|.||.  |  |...   .    . | |  .|    . ..|..|.  ..|  |  .   .|| ..
ndpelareilnilkvarns.k.......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4388-4514 1.2e-14 48.8 In-house 210-341 (350) alignment 
Range on Protein: 4388-4514
Range on HMM: 210-341/350.0
NQTDNFIertlllekegtertVTHYQYLAWTDHG---VPESTAPLVG----LLRQVKVTNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMD------A-
  .| ..              | . |.  | | .    |||  . .     |. .    .  | | . ||.||||||||||||... |.|.         
aasdPyv..............vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenl

IQRSTATDYI----D-VAGTIAKIREQRALLVQTLYQYIYLHRTVL
 ..|.  |.     | .  .. ..|.||  .||.| |.|... ..|
tkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
0048076 (Phosphotyrosine protein) phosphatases II 4397-4514 4.5e-24 80.2 In-house 35-140 (145) alignment 
Range on Protein: 4397-4514
Range on HMM: 35-140/145.0
TLLLEKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaatGPIVVHCSAGVGRTGTFIAADMLMDaiqrstatDYIDVAGTIAKIREQR
.|  |.|. ||....|.|| | |||||.... |  .|....   .|.    ||..||||||||||||..||....           ...  .....|.||
nltselellerlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsqr

ALLVQTLYQYIYLHRTVL
   |..  |...|.. .|
pgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 4401-4511 2e-22 74.9 In-house 41-139 (144) alignment 
Range on Protein: 4401-4511
Range on HMM: 41-139/144.0
EKEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaatGPIVVHCSAGVGRTGTFIAADMLMdaiqrstaTDYIDVAGTIAKIREQRALLV
|.|  ||....|..| | |||||.... |  .|. ..   .|.    ||..||||||||||||..||....        .  ...  ..| .|..|   |
epefleregiqylhlpwpDhgvpdllellleflefieealeeg....gpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrsrrpgav

QTLYQYIYLHR
..  |...|..
pnpgqlrfLle
0038934 (Phosphotyrosine protein) phosphatases II 4402-4471 1.3e-09 33.4 In-house 72-139 (194) alignment 
Range on Protein: 4402-4471
Range on HMM: 72-139/194.0
KEGTERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDgaATGPIVVHCSAGVGRTGTFIAADMLM
.|  |.   .|  | . |.|.. |.. |   |. |.. ..||  . | ..||| ||.|||||..|| ...
peefekagieylklpfpddgtvPsleillrfldlvdeflned..pggvvaVHCkaGlgRtGtlvaaYLiy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 4406-4515 2.1e-19 64.2 In-house 88-192 (440) alignment 
Range on Protein: 4406-4515
Range on HMM: 88-192/440.0
ERTVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTnqEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQRStatDYIDVAGTIAKIREQRALLVQTLYQ
 ||. .|.| .| |.|||. ..|.. ....|. .  .. |. ||..||||||.||||  || | ..   .||   | ||.   |  .|..|  .|||  |
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes..qekagngpllvhcsagagrtgviiavdsilreakrs...dqidifsfinsmrnnrpqmvqtpeq

YIYLHRTVLS
| ..| .|| 
yafvheavle
subfamily_PTPDC1_pd Subfamily PTPDC1 4406-4507 4.6e-09 31.0 In-house 80-166 (182) alignment 
Range on Protein: 4406-4507
Range on HMM: 80-166/182.0
ERTVTHYQYlAWTDHGVPestaPLVGLLRQVKVTNQedGAATGPIVVHCSAGVGRTGTFIAADMLMDaiQRSTAtdyidvAGTIAKIREQRALLVQTLYQ
|. ...|.. .|.|.||.    .|  .|  ||| ..      | . ||| || ||||  ||. ..    .| ||      . .| ..|..|.  .||  |
eqgiyvynf.gwkDygva....sleriLdivkvvaf..alqegkvavhChaGlGrtGvliacylvya..krlta......ekaiklvrskrpksiqtreq

YI
  
ve
PTPc_DSPc_SM00012 4408-4514 7.5e-33 108.2 In-house 1-104 (105) alignment 
Range on Protein: 4408-4514
Range on HMM: 1-104/105.0
TVTHYQYLAWTDHGVPESTAPLVGLLRQVKVTNQEDGAaTGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTatDYIDVAGTIAKIREQRALLVQTLYQYI
||.||.|..|.||||||.. ... |||.||  ... .  ..|.||||||||||||||.|.|.|.. ....|  . .|.  .. ..|.||. .|||..||.
tvkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqyl

YLHRTVL
.|.| .|
flyrall
PTEN_1 4414-4482 1.6e-06 23.0 In-house 99-163 (196) alignment 
Range on Protein: 4414-4482
Range on HMM: 99-163/196.0
YLAWTDHGVPestaPLVGLLRQVKVTNQEDGA--ATGPIVVHCSAGVGRTGTFIAAdMLMDAIQrSTATDY
 . ..|||.|    .|  |.. .|.  .   .    . ..||| ||.||.|| .||  || . . .|| . 
hfpieDhgap....slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa.yLmykgk.ltadeA
subfamily_CDC14_pd Subfamily CDC14 4436-4472 1.8e-06 22.0 In-house 256-288 (328) alignment 
Range on Protein: 4436-4472
Range on HMM: 256-288/328.0
VKVTNQEdgaaTGPIVVHCSAGVGRTGTFIAADMLMD
......     .| |.||| ||.|||||.||. .. .
leiaeka....eGaiavhCkaGLGrtGtLiacylmkh
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4439-4515 6.3e-08 26.3 In-house 257-342 (349) alignment 
Range on Protein: 4439-4515
Range on HMM: 257-342/349.0
TNQEDGAATGPIVVHCSAGVGRTGTFIAADMLMDAIQ----RSTATDYID-----VAGTIAKIREQRALLVQTLYQYIYLHRTVLS
 .  | . . ...|||||| ||||...  |.|.. ..     |   ..       .  .. ..| ||  .|| | |.| .. ..| 
rlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_CG42327_pd Subfamily CG42327 4446-4513 4.3e-15 50.2 In-house 246-311 (319) alignment 
Range on Protein: 4446-4513
Range on HMM: 246-311/319.0
ATGPIVVHCSAGVGRTGTFIAADMLMDAIQRSTATdyIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
  ||.||||| ||||||. ||.|. .  .. |  .  .|.  ..  .|..||  |.|  || ......
sqGPlvvhcsdGvGrtGlviasdiairsleeskrs..vdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 4450-4513 8.6e-09 29.7 In-house 1-61 (69) alignment 
Range on Protein: 4450-4513
Range on HMM: 1-61/69.0
IVVHCSAGVGRTGTFIAADMLMDaiqRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
.|||||.| ||||||||  . |    |  .   .|.   .  .|  | ..|    .||..| ..
mvvhcssgtgrtgtfiaimvema...rikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 4451-4513 4.6e-08 27.3 In-house 1-60 (69) alignment 
Range on Protein: 4451-4513
Range on HMM: 1-60/69.0
VVHCSAGVGRTGTFIAADMLMdaiQRSTATDYIDVAGTIAKIREQRALLVQTLYQYIYLHRTV
|||||.| ||||||||  . |    |  .   .|.   .  .|  | ..|    .|...| ..
vvhcssGtGrtGtfiaimvem...arikseklvdifnnvqymrkcrpmmvmneneymfihdal