Gene FIG4 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily FIG4
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP118_AA protein Get Run
SpurP118_AA_226-574 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Sac_COG5329 12-598 1e-111 365.9 In-house 2-540 (1070) alignment 
Range on Protein: 12-598
Range on HMM: 2-540/1070.0
KIVLYETKARFYIIGSNNAETEFRVLkidRTEARELLLTDDKISYTLPQIKDLLQTLRHGnrgaspapssssnpmagwsrnVSAFGIAGFVRFLEGYYII
||.|.|.| | ..|.||. .. || |     .  || .........   .|  .. |.                          .|. |.. . . ...|
killsekktRsiaivsnkyalvfrrl...svknselsvcaaelvavselkkegfrslssa.....................heiygvlGlielegslfli

LITKRKKV-AIIGGHTIYKIEDTTMVHIPHDNFRKQHP--DEARYLK--------MFQNVDLSSNFYFSYSYDLTHSLQHNlSAYQNKGEVGNprvvpih
.||. .|| ..|.|.|||||..  .. .  ... ..    |||.. |         .. ..  . ||||. .|.| .||.. .  . .  | .       
vitgkskvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsngsFYfStdfditntLqkr.lkeelelsvdt.......

TKPKFAWNHYLWNRF---QDQVHPC---------WAIHVIHGFVGQCNICVFGRPVLMTLVARRSAHYAGTRFLKRGANSEGGVANEVETEQIVHEAsls
 . .| ||..| . .    .. ..          .  .||.||. . .| | .. . .||..||| . ||||||.|| . .| |||.|||||||  .   
adeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvDddGnvanFVETEqIvyss...

elkrGRFASYVQHRGSVPALWSQDiTTMVPKPPINIDMADP-FAHLAGRHVNDLFSRFGSpVIVVNLVKKREkrkRESHLTEALSASLSyLNQFLPPkhq
     .  |..|.|||.|  |.|.  .   .|.|.|   .. .  .. .|   ||.. |  | .|||.|. .   .|  |.|...  |  |.....    
....qycfsFtQvRGSiPiFWeqe.snsligpkiqitrsseatqsafdkHFdklfekYGd.vhivNLlktKs...sEieLseryekhlk.lsekpki...

vQYIHLDMARYTKNKNADVMSKLEKIASRSVEKTGIFLSghaihpsipvregartdipqEGSCEQVFIRQMGVVRTNCVDCLDRTNTAQFVTGKYALGHQ
 .... |. . |.... |...||.. .  ...  | |                      ...  ... .| ||.|||| |||||||..|.. .| .|. |
.hlteFdfhketsqdgfddvkkLlplieqdllefgyfsy....................dvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleq

LYSLGVVADPELEfdsDVVRMLEDLYEDMGDTLALQYGGSQLVHSISTYRKIAPWTSHSRDIKQTLSRYYSNAFSDNDKQSAINLFLGVFTPREGRPNLW
..|..|... . |   | .  |. |. | ||... .|.|.. . |  |....  . ....|. .  ||.|.| | |  ||.||.|.|| . ..|. . ..
frsikvisaidde...dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklpdqeavelyd

ELPTDYYLHHT
.  .. .|. .
pineyvnlrlr
subfamily_FIG4_pd Subfamily FIG4 13-599 3e-279 918.2 In-house 1-563 (569) alignment 
Range on Protein: 13-599
Range on HMM: 1-563/569.0
IVLYETKARFYIIGSNNAETEFRVLKIDRTEARELLLTDDKISYTLPQIKDLLQTLRHGNRGaspapssssnpmaGWSRNVSAFGIAGFVRFLEGYYIIL
.||||||||.|..|||..||.|||||||||..|||....||...|  .||.||..|...||              |....|||.|| ||||||||||.||
lvlyetkarlylvGsnkretkfrvlkidrtverelvvledkveftkneikellasleeanrd.............glekkvsayGilGfvrflegyylil

ITKRKKVAIIGGHTIYKIEDTTMVHIPHDNFR-KQHPDEARYLKMFQNVDLSSNFYFSYSYDLTHSLQHNLS--AYQNKGEVGNPRVV------PIHTKP
.|||||||.||||.||||||.....|..|. . ....|||||||.|..|||..|||||||||||..||.||.  ..... |  ..||        .... 
vtkrkkvaviGghaiykiedialikitedskksekssdearylklfkdvdltknfyfsysydltrtlqtnlllsdsnrekekaedrvditieakkldane

KFAWNHYLWNRFQDQVHP-CWAIHVIHGFVGQCNICVFGRPVLMTLVARRSAHYAGTRFLKRGANSEGGVANEVETEQIVHEASLSELKRGRFASYVQHR
||.||..|.....|.|.. .| ...||||| |..|.|.|... .||.||||...||.||||||.|..| ||||||||||||||| ..|...|..|.||.|
kfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqivheasegsldsdryssfvqlr

GSVPALWSQDITTMVPKPPINIDMADPFAHLAGRHVNDLFSRFGSPVIVVNLVKKREKRKRESHLTEALSASLSYLNQFLPPKHQVQYIHLDMARYTKNK
||||. ||||....|.||||.||..||||. | .|..|||.|.|||.|..|||||.|||||||.|.|...|...|||.|||......||..||||..|.|
GsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylneflPeekklkyiswdmarasksk

NADVMSKLEKIASRSVEKTGIFLSGHAIHPSIpvregartdipqegsceqvfiRQMGVVRTNCVDCLDRTNTAQFVTGKYALGHQLYSLGVVADPELEFD
...|...|||.|..||.|||||||........                     .|.|.|||||||||||||.||||.||.|||.||.|||......||||
eenvlevlekyaeksvkktGiflsapdlestk.....................iqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiidesklefd

SDVVRMLEDLYEDMGDTLALQYGGSQLVHSISTYRKIAPWTSHSRDIKQTLSRYYSNAFSDNDKQSAINLFLGVFTPREGRPNLWELPTDYYLHHTD
|||||.||.||||.||||||||||||||..|.||||||.|.|.|||| .||.|||||.|.|.|||.||||||||..||||.|.||||.||.|||...
sdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvyspreglpslWeletdfylhnay
subfamily_SAC1_pd Subfamily SAC1 93-580 6.8e-86 279.7 In-house 5-456 (458) alignment 
Range on Protein: 93-580
Range on HMM: 5-456/458.0
VSAFGIAGFVRFLEGYYIILITKRKKVAIIGGHTIYKIEDTTMVHIPHDNF---RKQHPDEARYLKMFQNVDLSSNFYFSYSYDLTHSLQHNLSAyQNKG
|. .|| |... | | |.|.|||...|. | |..||...|.... . . ..    .|. .|..|||. ..|  |..||||| ||||.|||.. .  ... 
vkiagilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekv.tsaa

EVGNPrvVPIHTKPKFAWNHYLWNRF-QDQVHPCWAIHVIHGFVGQCNICVFGRPVLMTLVARRSAHYAGTRFLKRGANSEGGVANEVETEQIVHEAsls
   ..  .   .  .| ||..| ... ...    . . ||.||. . .. . .... ..|..||| . ||||. .||...|| ||| |||||||.     
lkers..lleradeRffwnkhlledlrkepelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveae...

elkrGRFASYVQHRGSVPALWSQdITTMVPKPPINIDMADPFAHLAGRHVNDLFSRFGSPViVVNLVKKRekrKRESHLTEALSASLSYLNqflppKHQV
      ..|.|| |||.| |||| . ..  || ...   .   .   .|.... ...|. | .|||| ..    .| .| ||..  .. ||     |...
....kaltsFvqvRGsiPllWsq.kpnLkykPkvklsesedsldafkkhldeqielygenv.lvnLvdqk...GsEkklgeayesvvraln.....kkki

QYIHLDMARYTKNKNADVMSKLEKIASRSVEKTGIFLSghaihpsipvregartdipQ---EgsceqVFIRQMGVVRTNCVDCLDRTNTAQFVTGKYALG
.|.  |  .  ..   | ...| .  .. ....|.||                    .   .     .  .| |||||||.|||||||  | . ....| 
kyvafDFHkeCrkmrwdrlklLidqlekelsqegyflk...................seekk.....ivkeqkgvvRtnCiDcLDRtnvvqsllarevLq

HQLYSLGVVAD-PELEFDSDVVRMLEDLYEDMGDTLALQYGGSQLVHSISTYRKIAPWTSHSRDIKQTLSRYYSNAFSDNDKQSAINLFLGVFTPR
.|| ||||.|   .||  ... ..  .|. | .|... || | .   .  |       .   ||. ...|||| | |.|. .|..|.|||| ....
kqleslgvlateskledsaeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrve
Syja_N SacI homology domain 95-405 2e-89 290.9 Pfam-A 1-318 (319) alignment 
Range on Protein: 95-405
Range on HMM: 1-318/319.0
AFGIAGFVRFLEGYYIILITKRKKVAIIG-GHTIYKIEDTTMVHIPHDNFRKQ---------HPDEARYLKMFQNVDLSSNFYFSYSYDLTHSLQHNLSA
|.|| |..|.|...|...||||.||| |. .|.||||... ........ ...         ...|...||...... |..|||||.||||.|||.. ..
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

YQNKGEVG-NPRVVPIHTKPKFAWNHYLWNRFQDQV--HPCWAIHVIHGFVGQCNICVF-GRPVLMTLVARRSAHYAGTRFLKRGANSEGGVANEVETEQ
 ... | . .      .....| ||..| . ...       | . .|.|||.| .| |  .. | .||..||| ..||||.|.||....| |||.|||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IVHEA-SlselKRGRFASYVQHRGSVPALWSQdITTMVPKPPINID-MADPFAHLAGRHVNDLFSRFgSPVIVVNLVkkrEKRKRESHLTEALSASLSYL
||.|  .    ...|. |.||.||||| .|.|  ... .||.|.|.   ..  . . .|...|..|. ....||||.   ||..||. |.||. . ...|
ivsekke....eskrvfSfvqiRGSvPlfWeq.asnlslkpkikitrsseasqkafkkHfkklikrY.gkivvvnLl...ekkgrEkkLseayeelinkl

NQFLPPKHQVQYIHLDMARYTKNKNAD
|..|. |....||. |. . .|.|. .
nkklkekkklkyiefDfhkeckgkkfe
Syja_N SacI homology domain 95-405 2e-89 290.9 In-house 1-318 (319) alignment 
Range on Protein: 95-405
Range on HMM: 1-318/319.0
AFGIAGFVRFLEGYYIILITKRKKVAIIG-GHTIYKIEDTTMVHIPHDNFRKQ---------HPDEARYLKMFQNVDLSSNFYFSYSYDLTHSLQHNLSA
|.|| |..|.|...|...||||.||| |. .|.||||... ........ ...         ...|...||...... |..|||||.||||.|||.. ..
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

YQNKGEVG-NPRVVPIHTKPKFAWNHYLWNRFQDQV--HPCWAIHVIHGFVGQCNICVF-GRPVLMTLVARRSAHYAGTRFLKRGANSEGGVANEVETEQ
 ... | . .      .....| ||..| . ...       | . .|.|||.| .| |  .. | .||..||| ..||||.|.||....| |||.|||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IVHEA-SlselKRGRFASYVQHRGSVPALWSQdITTMVPKPPINID-MADPFAHLAGRHVNDLFSRFgSPVIVVNLVkkrEKRKRESHLTEALSASLSYL
||.|  .    ...|. |.||.||||| .|.|  ... .||.|.|.   ..  . . .|...|..|. ....||||.   ||..||. |.||. . ...|
ivsekke....eskrvfSfvqiRGSvPlfWeq.asnlslkpkikitrsseasqkafkkHfkklikrY.gkivvvnLl...ekkgrEkkLseayeelinkl

NQFLPPKHQVQYIHLDMARYTKNKNAD
|..|. |....||. |. . .|.|. .
nkklkekkklkyiefDfhkeckgkkfe
subfamily_Synaptojanin_pd Subfamily Synaptojanin 95-427 1.2e-33 107.6 In-house 6-316 (754) alignment 
Range on Protein: 95-427
Range on HMM: 6-316/754.0
AFGIAGFVRFLE----GYYIILITKRKKVAIIGGHTIYKIEDTTMVHIphdnfRKQHPDEARYLKmFQNVDLSSNFYFSYSYDLTHSLQHNLSAYQNKGE
|.|. | .|         ...|.|  |.|  | .  |.|| .|..| .     |..  || |. .  ...  | .|||| | | ...|. .||| ..| |
aygllGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvsl.....rseasdedriie.lkkllasgtfyfsssadsasrldlslsaqrrkqe

VgnprvvpiHTKPKFAWNHYLWNRFQDQVHPC--WAIHVIHGFVGQCNICVFGRPVLMTLVARRSAHYAGTRFLKRGANSEGGVANEVETEQIVHeasLS
          .  .| ||. |.  .|     |  | ..|. | |    . .  . . ..|..| |.  |||||  ||.| || ||| |||||..    | 
e........sednrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvil...ld

elkrGRFASYVQHRGSVPALWSQDITtMVPKPPINIDMADPFAHL-AGRHVNDLFSRFGSpVIVVNLVkkrEKRKRESHLTEALSASLSyLNQFlppKHQ
     . .|.|| ||||| .|.|     | .  ...  .   ..    ||.. | .|.|. |..|||.    ... |. |..|    |   ...   ...
....dkvtsfvqirGsvPlfWeqPGl.qvGshkvklsrgfeasaaafdrhleqlkeryGe.vvivnll...Gskegeevlskafkkhlk.aseh...akd

VQYIHLDMARYTKNKNA-DVMSKLEKIASRSVEKTGIFLSG
|.....|. . .| ...  ... |.|.... .|....||| 
vpfvkfdyhqkvkggkkeklekllkkqlklflesasfflsk
subfamily_INPP5F_pd Subfamily INPP5F 139-576 2.4e-69 225.4 In-house 111-505 (951) alignment 
Range on Protein: 139-576
Range on HMM: 111-505/951.0
PHDNFRKQHPDEARYLKMFQNVDLSSNFYFSYSYDLTHSLQHNLSAYQNKGEVGNprvvpihtKPKFAWNHYLWNRFQDQVHPC---WAIHVIHGFVGQC
 . . ....  | | |.  ..   . .||.|...|||..||..    ...    .          .| ||..| . . .  .     . . || |||   
eekeqneeeklekrlleelkkllsdgsFYysldfDltntlqkrgleeksestddw........derFfWNkfllkdlinyrdkldkefltpviqGfvetk

NICVFGRPVLMTLVARRSAHYAGTRFLKRGANSEGGVANEVETEQIVHEASLsElkrgrfASYVQHRGSVPALWSQDITTMVPKPPINIDMADPfAHLAG
.| .    | .||. ||| . ||||| .|| . .| |||.||||.|.. ..          |..| |||||  |.|.   . ||. |. . ..   .   
eisieklkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsveky.v......lsftqirGSvPvfweqsgkkykpkikitrseeet.qpaFd

RHVNDLFSRFGSpVIVVNLVKKrekRKRESHLTEALSASLSYLNqflppKHQVQYIHLDMARYTKNKNADVMSKLEKIASRSVektgiflsghaihpsip
.|.. .....|  | .|||...   ...|..| .| .  |  |.     ...| .|..|. ..|.... . .||| .    ..                 
ehfkeqlkkygk.vvivnllsq...kssekklskaykeqllkle.....skdvflikfdfheetsgekfenvsklieliknei.................

vregARTDIPQEGSCEQVFIRQMGVVRTNCVDCLDRTNTAQFVTGKYALGHQLYSLGVVADPELEFDSDVVRMLEDLYEDMGDTLALQYGGSQLVHSIST
     .       . |.|. .| ||.||||.|||||||..|   .| .|  ||  ||..   . . |..... |..|. | ||..  || |.. . .  |
....kevgyfsydvkekviseqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessiddeellqklkklWadngdaisrqYagtnalkgdlt

YRKIAPWTSHSRDIKQTLSRYYSNAFSDNDKQSAINLFLGV
       .    | ....|||| | | |. .| .|.| || 
rkgerklaGvlkdgyksvsryylnnfkdkyrqkvidlllGk
subfamily_Synaptojanin_pd Subfamily Synaptojanin 452-574 1.5e-19 61.0 In-house 319-432 (754) alignment 
Range on Protein: 452-574
Range on HMM: 319-432/754.0
QVFIRQMGVVRTNCVDCLDRTNTAQFVTGKYALGHQLYSLGVVADPelEFDSDVVRMLEDLYEDMGDTLALQYGGSQLVHSISTyrkiapwTSHSRDIKQ
.|  .|.||.|.||.|||||||. | | |   | .||  |..   .  .  | . .....|..  || ..  | |.. ... .        .|  .| ..
evekeqtGvlrvnClDCldrtnavqtvlglevlekqlealklsske..svvsrfeevfkslWsknGdeiskiyaGtgalegkak.......vsklkdgar

TLSRYYSNAFSDNDKQSAINLFL
...|   | | |. || ||.|.|
svartiqnnfldsskqeaidlll