Gene SAC1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily SAC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP120_AA protein Get Run
SpurP120_AA_186-499 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_INPP5F_pd Subfamily INPP5F 51-508 3.5e-126 413.6 In-house 63-512 (951) alignment 
Range on Protein: 51-508
Range on HMM: 63-512/951.0
ASKPICGIMGIIKLLRGSYLVVITKKTKVgeinGQLIWKVAGTETI--PYKRTDLHLTEEQKEDNKVYESMVQYaLENNTYYFSTTFDLTHSLQRLYNTs
 .. . |..|.|.|    .. .|..|.||     .  |..  ...   . ..   .  ||.|......| . .  |.....|.|..||||..||.  .. 
ekeectgliglielegkiivatiegkskv....nnkkwdlididssgylqlkeekeqneeeklekrlleelkkl.lsdgsFYysldfDltntlqkrgle.

PEFLQMPLFeraDQRYVWNGHMLREFTAQPELG--KFILPVMVGFISIRIGILNTKRFDYILISRRSCLRAGTRFYMRGLDEQGQAANFVETEQIVQFNG
..  ... .   |.|..|| ..|.....  .    .|..||. ||....    . ..... ||||||  ||||||. || |..|. |||||||.|.... 
eksestddw...derFfWNkfllkdlinyrdkldkefltpviqGfvetkeisieklkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvek

SRASFVQTRGSIPLFWSQRpNLKYKPVPHISESQ-SHLDAFKRHFDDQVVNYGNQVLINLIDHKGAENRLEKMFAKTVYESGNQMMRYEAFDFHHECRKM
   ||.| |||.|.||.|. . |||| ..|  |.     ||..||. |. .||..| .||...|. |  | | ... . .. .. . .  ||||.|....
yvlsftqirGSvPvfweqs.gkkykpkikitrseeetqpaFdehfkeqlkkygkvvivnllsqkssekklskaykeqllkleskdvflikfdfheetsge

RWDRLSILMDKLAKDQQQFGYFWMDANNELLKHQVGVFRTNCMDCLDRTNVVQSMLARRALQDQMQQMGILKQGENLDDhytAAFESTFKNTWADNADAC
... .| |.... .. ...|||..| ..... .| |||||||.||||||||||..... .|. |....|...  . .||   . . ...|..|||| || 
kfenvsklielikneikevgyfsydvkekviseqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessidd...eellqklkklWadngdai

SKQYAGTGALKTDFTRTGKRTKFGLLKDGMNSLIRYYMNNFVDGFRQDSTDLLLGNYVVEEGE
|.||||| ||| |.||.|.|  .|.||||..|. |||.|||.| .||.  |||||.   .| .
srqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkvidlllGklpkqevv
subfamily_SAC1_pd Subfamily SAC1 52-505 2e-221 726.5 In-house 4-456 (458) alignment 
Range on Protein: 52-505
Range on HMM: 4-456/458.0
SKPICGIMGIIKLLRGSYLVVITKKTKVGEINGQLIWKVAGTETIPYKRTDLHLTEEQKEDNKVYESMVQYALENNTYYFSTTFDLTHSLQRLYN-TSPE
.. |.||.||||||.|.||.|||||..||.|||. |..|| .| ||.|...|.||||||...| | .... .|...|.|||.|.|||.|||||.. ||..
vvkiagilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekvtsaa

FLQMPLFERADQRYVWNGHMLREFTAQPELGKFILPVMVGFISIRIGILNTKRFDYILISRRSCLRAGTRFYMRGLDEQGQAANFVETEQIVQFNGSRAS
. ...|.||||.|..||.|.|......||| .|||||. |||.|.   ||.|....|||||||. |||||...||.|..|..||||||||||... . .|
lkerslleradeRffwnkhlledlrkepelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveaekalts

FVQTRGSIPLFWSQRPNLKYKPVPHISESQSHLDAFKRHFDDQVVNYGNQVLINLIDHKGAENRLEKMFAKTVYESGNQMMRYEAFDFHHECRKMRWDRL
|||.||||||.|||.||||||| ...|||...|||||.|.|.|. .||..||.||.|.||.|..|.......| ........|.|||||.||||||||||
FvqvRGsiPllWsqkpnLkykPkvklsesedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayesvvralnkkkikyvafDFHkeCrkmrwdrl

SILMDKLAKDQQQFGYFWMDANNELLKHQVGVFRTNCMDCLDRTNVVQSMLARRALQDQMQQMGILKQGENLDDHytAAFESTFKNTWADNADACSKQYA
..|.|.|.|...|.|||........ |.| ||.||||.|||||||||||.|||..||.|....|.|.....|.|.  |..|..|||.|||||||.|.|||
klLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskleds..aeletsfknlwadnadavsvqYa

GTGALKTDFTRTGKRTKFGLLKDGMNSLIRYYMNNFVDGFRQDSTDLLLGNYVVE
||||||||||||||||..|.|.||.||..|||.|||.||.||||.||.||.|.||
GtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrve
Sac_COG5329 52-503 1.3e-135 444.9 In-house 57-520 (1070) alignment 
Range on Protein: 52-503
Range on HMM: 57-520/1070.0
S-KPICGIMGIIKLLRGSYLVVITKKTKV-GEINGQLIWKVAGTETIPYKRTDLHLTEEQKEDNKVYE-----SMVQY--ALENNTYYFSTTFDLTHSLQ
| . | |..|.|.|   ..| |||.|.|| . |.|. | |. . . |.... .    |. .. .....     .. .    | | ..||||.||.| .||
saheiygvlGlielegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsngsFYfStdfditntLq

RLYNTSPEflqmPLFERADQRYVWNGHMLREFT----AQPELGK-------FILPVMVGFISIRIGILNTKRFDYILISRRSCLRAGTRFYMRGLDEQGQ
.  .. .|    . ...||....||  .|.|.       ..| |       |. .|  ||..     .. |     ||||||  ||||||  ||.|. |.
krlkeele....lsvdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvDddGn

AANFVETEQIVQFNGSRASFVQTRGSIPLFWSQ-RPNLKYKPVPHISESQSHLDAFKRHFDDQVVNYGNQVLINLIDHKGAENRLEKMFAKTVYESGNQM
.||||||||||. .    ||.|.|||||.||.| . .| ....    .|.   .||..||| .. .|| ....||.. |. |  | . . | . .| .  
vanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivNLlktKssEieLseryekhlklsekpk

MRYEAFDFHHECRKMRWDRLSILMDKLAKDQQQFGYFWMDAN-NELLKHQVGVFRTNCMDCLDRTNVVQSMLARRALQDQMQQMGILKQGENLddhytaA
. .  ||||.|......|... | .....|  .||||  | .  .|.. | |||||||.||||||||.|.....|.|. |.. ... .....        
ihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde......d

FESTFKNTWADNADACSKQYAGTGALKTDFTRTGKRTKFGLLKDGMNSLIRYYMNNFVDGFRQDSTDLLLGNYV
| . ... ||||.|| |..| ||||||..|||.|||. .| |.| ..|  |.|.|||||. .||. ||||| . 
flqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklp
Syja_N SacI homology domain 55-348 3e-94 306.7 Pfam-A 1-318 (319) alignment 
Range on Protein: 55-348
Range on HMM: 1-318/319.0
ICGIMGIIKLLRGSYLVVITKKTKVGEING-QLIWKVAGTETIPYKRTDLHLT------EEQKEDNKVYESMVQYALENNTYYFSTTFDLTHSLQRLYNT
..||.|.|.||..|||.||||..||..|.| . |.|.  .|.|| .... . .      ||...... . ..... |.....|||...|||.|||| ...
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

SP-----EFLQMPLFERADQRYVWNGHMLREFTAQP-ELGKFILPVMVGFISIRIGILN-TKRFDYILISRRSCLRAGTRFYMRGLDEQGQAANFVETEQ
.      |  ..||....|.|.||| ..|....    .| ...||.. ||...|   ..  |.....||||||. |||||.  ||.|..|..||||||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IVQF--N--GSRASFVQTRGSIPLFWSQRPNLKYKPVPHIS-ESQSHLDAFKRHFDDQVVNYGNQVLINLIDHKGAENRLEKMFAKTVYES-----GNQM
||..  .  ..  ||||.|||.||||.| .||..|| ..|. .|... .|||.||.... .||..|..||...|| |. |.. ... . .       .. 
ivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkk

MRYEAFDFHHECRKMRWD
..|..||||.||......
lkyiefDfhkeckgkkfe
Syja_N SacI homology domain 55-348 3e-94 306.7 In-house 1-318 (319) alignment 
Range on Protein: 55-348
Range on HMM: 1-318/319.0
ICGIMGIIKLLRGSYLVVITKKTKVGEING-QLIWKVAGTETIPYKRTDLHLT------EEQKEDNKVYESMVQYALENNTYYFSTTFDLTHSLQRLYNT
..||.|.|.||..|||.||||..||..|.| . |.|.  .|.|| .... . .      ||...... . ..... |.....|||...|||.|||| ...
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

SP-----EFLQMPLFERADQRYVWNGHMLREFTAQP-ELGKFILPVMVGFISIRIGILN-TKRFDYILISRRSCLRAGTRFYMRGLDEQGQAANFVETEQ
.      |  ..||....|.|.||| ..|....    .| ...||.. ||...|   ..  |.....||||||. |||||.  ||.|..|..||||||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IVQF--N--GSRASFVQTRGSIPLFWSQRPNLKYKPVPHIS-ESQSHLDAFKRHFDDQVVNYGNQVLINLIDHKGAENRLEKMFAKTVYES-----GNQM
||..  .  ..  ||||.|||.||||.| .||..|| ..|. .|... .|||.||.... .||..|..||...|| |. |.. ... . .       .. 
ivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkk

MRYEAFDFHHECRKMRWD
..|..||||.||......
lkyiefDfhkeckgkkfe
subfamily_FIG4_pd Subfamily FIG4 56-507 1.1e-83 272.6 In-house 71-546 (569) alignment 
Range on Protein: 56-507
Range on HMM: 71-546/569.0
CGIMGIIKLLRGSYLVVITKKTKVGEINGQLIWKVAGTETIPYKRTDLHltEEQKEDNKVYESMVQYALENNTYYFSTTFDLTHSLQRLYN-----TSP-
 ||.|....|.| ||...||. ||. | |  |.|. ... |. ...  .  .|.. |.. |  . .    ....||| ..|||..||         ..  
yGilGfvrflegyylilvtkrkkvaviGghaiykiedialikitedskk..sekssdearylklfkdvdltknfyfsysydltrtlqtnlllsdsnreke

------EFLQMPLFERADQRYVWNGHMLREFTAQPELGKFILPVMVGFISIRIGILNTKRFDYILISRRSCLRAGTRFYMRGLDEQGQAANFVETEQIVQ
      .        .|....||| ..|  .... .  ...| .. ||.|     . .|. . .||.|||   ||.||  || ...|. || |||||||.
kaedrvditieakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqivh

-------FNGSRASFVQTRGSIPLFWSQRP-NLKYKPVPHISESQSHLDAFKRHFDDQVVNYGNQVL-INLIDHKG---AENRLEKMFAKTVYE-----S
        ... .||||.|||.||.|||   .|. ||  .| . . ...|  .|||| . .||. .. .||. .|     |. |.. | ...        
easegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylneflP

GNQMMRYEAFDFHHECRKMRWDRLSILMDKLAKDQQQFGYFWMDANNELLKHQVGVFRTNCMDCLDRTNVVQSMLARRALQDQMQQMGILKQgENLDdhY
 .. ..| ..|...  ..   . |..| .   |  .. |.|   .. |  | | |. ||||.|||||||. | .....||. |....||...  .|.  .
eekklkyiswdmaraskskeenvlevlekyaeksvkktGiflsapdlestkiqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiide.skle..f

TAAFESTFKNTWADNADACSKQYAGTGALKTDFTRTGKRTKFGLLKDGMNSLIRYYMNNFVDGFRQDSTDLLLGNYVVEEG
 .     ... . |  |  . ||.|.   .|  | .  ..     .| ...| ||| | |||  .||. .|.|| |. .||
dsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvyspreg
subfamily_Synaptojanin_pd Subfamily Synaptojanin 57-505 2e-93 305.2 In-house 8-439 (754) alignment 
Range on Protein: 57-505
Range on HMM: 8-439/754.0
GIMGIIKLLR----GSYLVVITKKTKVGEINGQLIWKVAGTETIPykrtdlhLTEEQKEDNKVYEsmVQYALENNTYYFSTTFDLTHslqrLYNTSPEFL
|..|...|       |.||..|  ..|| |..  |.|.. || ..       | .| ...... |  ..  |. .|.|||.. | ..     .. | .  
gllGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvs.......lrseasdedriie..lkkllasgtfyfsssadsas....rldlslsaq

QMPLFERADQRYVWNGHMLREFTA-QPELGKFILPVMVGFISIRIGILNTKRFDYILISRRSCLRAGTRFYMRGLDEQGQAANFVETEQIVQFNGSRASF
.    |  |.|..||  .   ..  . .  ...|.|| | ..||.    .|.   .|||| || ||||||..||....|..||||||||.. .. . .||
rrkqeesednrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvillddkvtsf

VQTRGSIPLFWSQrPNL--KYKPVPHISESQSHLDAFKRHFDDQVVNYGNQVLINLIDHKGAENRLEKMFAKTVYESGN-QMMRYEAFDFHHECRKMRWD
||.|||.||||.| | |    . |    . ..   ||.||.. .  .||..|..||. .|..|. |.| | |   .|   . . .  ||.|....  . .
vqirGsvPlfWeq.PGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvkfdyhqkvkggkke

RLSILMDKLAKD-QQQFGYFwMDANNELLKHQVGVFRTNCMDCLDRTNVVQSMLARRALQDQMQQMGiLKQGenldDHYTAAFESTFKNTWADNADACSK
 |. |..| .|   .....| .  ..|. |.| || |.||.||||||| ||..|.   |..|.. .. |..      .    || .||. |  | | .||
klekllkkqlklflesasff.lskgkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlealk.lssk....esvvsrfeevfkslWsknGdeisk

QYAGTGALKTDftrtgkrTKFGLLKDGMNSLIRYYMNNFVDGFRQDSTDLLL-GNYVVE
 |||||||...       .| . ||||  |. |   |||.|. .|.. |||| ||  ||
iyaGtgalegk.......akvsklkdgarsvartiqnnfldsskqeaidllllgntyve