Gene PGP in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily PGP
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP139_AA protein Get Run
SpurP139_AA_15-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Hydrolase haloacid dehalogenase-like hydrolase 19-259 7.4e-14 44.0 Pfam-A 1-215 (215) alignment 
Range on Protein: 19-259
Range on HMM: 1-215/215.0
IDTILLDCDGVLWHSNMAF--PGAAETINKLRSM--------GKQPIFVTNN-STK-SrLQYQEKFTKMGFIVSKDEIfgtaycaalylkhklnftgkvY
|.|.. |..|.|......   .|... .. ....        ||...... . ||. . |.. ..| . |     |.|                     .
iktvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstrgg.ltgfatfigrgvsgkvdgi.....................v

LmgmsGLEEEMKLHSIDYIGTGPDNVEGQILDHRADHVVLdpDVNGVVVGFDQYFSFMKLLKAASYLKRPNS-VFIGTNiD---------QQFPMrnsel
|    | .| |.   ...|    ...|||  .. . .|    ..  . |  ..     .. .|  .||. .  |.. |. |         .|  .     
l....gnpewmtalglrviapdlvaaegqskgrtvvvvav..qaralgviafadpvkpeaaeavasLkeaGievvlltg.dnpetaeaiakqagi.....

impgtgslvRPVE-----VasnrtattlGKPSKFMFECIQEKFDVNPQRTIMIGDRLnTDILLGKNCG
           .      |         |||.. .|. . |.. ..|....|.||.. .|.  ....|
.........edslvfaevv.........gkPepklfvaaieeLqidpgevamvGDgv.nDapalaaAg
Chronophin_1 20-302 1.6e-78 254.7 In-house 2-256 (261) alignment 
Range on Protein: 20-302
Range on HMM: 2-256/261.0
DTILLDCDGVLWHSNMAFPGAAETINKLRSMGKQPIFVTNNSTKSRLQYQEKFTKMGFI-VSKDEIFGTAYCAALYLKHkLNFTGKVYLMGMSGLEEEMK
...|||.||||.. . | |||||.|..|.  ||. .||||||.. | .. ......|.  |...||| .|..|| .|..  . ..|||..| .|| .|..
qlvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrq.qaakakvyvlGeeglrkelr

LHSIDYIGTGPDnvegqildhradhvvldpDVNGVVVGFDQYFSFMKLLKAASYLKRPnSVFIGTNIDQQFPMRNSelIMPGTGSLVRPVEVASNRTATT
   .  ..   |                  .|. ||||.|. .||.|| .|. ... . . |. || |. .|...   |.||||||.. || ||.| .. 
eaGlrlvdeped..................rveaVvvGydeelsfeklaeaialirdg.alfvatnrDptvPleeG..iaPgtGslaaaveaAsgreplv

LGKPSKFMFECIQEKFDVNPQRTIMIGDRLNTDILLGKNCGLKTLAVLTGVTSEEEILGFQgsekekeRELVPDLYIESIGHLG
 |||. .|||...||....|..|.|.||||.|||| |...||.||.|||||...||.  ..       ..|.|| ..|||  | 
vGKPepvmfeealekigadpeetvmvGDRldTDilagaraglstllvltGvseleeaqayk.......kdlrPdavvesiadll
subfamily_PGP_pd Subfamily PGP 21-304 3.3e-112 365.3 In-house 1-278 (279) alignment 
Range on Protein: 21-304
Range on HMM: 1-278/279.0
TILLDCDGVLWHSNMAFPGAAETINKLRSMGKQPIFVTNNSTKSRLQYQEKFTKMGFI-VSKDEIFGTAYCAALYLKHkLNFTGKVYLMGMSGLEEEMKL
|.|.|||||||....|.|||||..|.|...||. .|||||||||| .. .||.|.||  |...||. .|...| |||.  .|..|||..|..||.||.| 
tvlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkq.kkfekkvyvlgeeglkeeLke

HSIDYIGTGPDNVEGQILDHRADHVVLDPDVNGVVVGFDQYFSFMKLLKAASYLKRPNSVFIGTNIDQQFPMRNsELIMPGTGSLVRPVEVASNRTATTL
..|...||||.. .... .. .... ||.||. ||||.|...|..||||||.||..|...|..|| |. .|... |...||.||||. .|.||.|....|
agiellgtgpeklkdeldedfveelkldkdvgAVvvgvdeklsyakllkAanyLrepevlflatneDallplkk.evvipgaGslvaaieaasgrkplvl

GKPSKFMFECIQEKFDVNPQRTIMIGDRLNTDILLGKNCGLKTLAVLTGVTSEEEILGFQGSEkekerELVPDLYIESIGHLGKL
|||.....|...||....|.||.||||||.||||.||||||.|| ||.|||..|..  .. .|     .||||.|..|...| .|
GKPnelllelllekeeidpertlmiGDrlktDilfgkncGlqtLlvlsGvtkledveeikkee.....klvPdyyldsladllel
Chronophin_2 21-302 2.3e-89 290.4 In-house 2-277 (282) alignment 
Range on Protein: 21-302
Range on HMM: 2-277/282.0
TILLDCDGVLWHSNMAFPGAAETINKLRSMGKQPIFVTNNSTKSRLQYQEKFTKMGFI-VSKDEIFGTAYCAALYLKHKLNFTGKVYLMGMSGLEEEMKL
..|.|||||.|  . | .||.| ...|  .||. .|||||||..| .| .||...||  | ...|| .|||.|.||..  .  |||. .|  || .|.. 
nvlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrdvadvrgkvfviggeglrkelre

HSIDYIGTgPDNVEGQILDhradhVVLDPDVNGVVVGFDQYFSFMKLLKAASYLKRPNSVFIGTNIDQQFPMRNSElIMPGTGSLVRPVEVASNRTATTL
  .  ..  .|. |  |.|     . |||||. |.||.|. ..|.|| ||..||. .. ... |. |   |... . |.||.|||   .|.||.| || .
agvpvved.adeqeasiyd.....caldpdvravlvgydekltflklakacaylrdadclllatdrdpwhplsdgr.itpgsgsltaaletasgrkatvi

GKPSKFMFECIQEKFDVNPQRTIMIGDRLNTDILLGKNCGLKTLAVLTGVTSEEEILGFQGSEKEKERELVPDLYIESIGHLG
||||.|||||| ..|.|.| |..||||||.||||.|.||||.|.  ||||.| ||   .. |.. ..|.|||| ..|||  | 
gkpsrfmfecissqfsvdparslmigdrletdilfgsncglstvltltgvssleeaqeysdsqlaeqrdlvpdyvvesiadll
subfamily_LHPP_pd Subfamily LHPP 22-272 4.1e-35 112.7 In-house 1-223 (227) alignment 
Range on Protein: 22-272
Range on HMM: 1-223/227.0
ILLDCDGVLWHSNMAFPGAAETINKLRSMGKQPIFVTNNSTKSRLQYQEKFTKMGFIVSKDEIFGTAYCAALYLKHKLNftGKVYLMGMSGLEEemkLHS
.|||  |||.  ..| |||.| ...||. |..  ||||.. .|. . .|. ...|| |...||| ..  |. .|...     ...|.  .  |.   .. 
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerkl..rpyllveddveed...fed

IDYIGTgpdnvegqildhradhvvldpdvNGVVVGF-DQYFSFMKLLKAASYLKR-PNSVFIGTNIDQQFPMRNSelIMPGTGSLVRPVEVASNRTATTL
||.                          | ||.|  .. |.. .| .|   |.. .. . |  | .. .  ..    . | |. |. .| | . .|. .
idtdkp.......................navviglapesfeyetlnqafrllleakkakliainkgkyykrkdG..lalgpGafvkaleyatgvkaevv

GKPSKFMFECIQEKFDVNPQRTIMIGDRLNTDILLGKNCGLKTLAVLTGVTSE
||||...||   |...|.|.. .|||| .. |.    ..||... | ||.  .
GKPsalffekaleelgvdpeeavmiGDdvedDveGAlkaGlrgvlVktGkfrp
Hydrolase_6 Haloacid dehalogenase-like hydrolase 22-121 1.7e-31 99.6 Pfam-A 1-99 (101) alignment 
Range on Protein: 22-121
Range on HMM: 1-99/101.0
ILLDCDGVLWHSNMAFPGAAETINKLRSMGKQPIFVTNNSTKSRLQYQEKFTKMGFIVSKDEIFGTAYCAALYLKHKlNFTGKVYLMGMSGLEEEMKLHS
.|.|.|||||. . |.|||||....||..||. ...||||.||. .|..|..|.|. |...... .|..|| ||| . .. .||...|  ||.||.| . 
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkr.kadkkvlvigeeglreelkeaG
HAD_2 Haloacid dehalogenase-like hydrolase 218-263 9.5e-08 23.8 Pfam-A 130-174 (176) alignment 
Range on Protein: 218-263
Range on HMM: 130-174/176.0
TLGKPSKFMFECIQEKFDVNPQRTIMIGDRLnTDILLGKNCGLKTL
   ||.. ..| . |...|.|.....|.|.|  |.  ....|..| 
gapKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtv
Hydrolase_like HAD-hyrolase-like 219-275 6.2e-20 62.3 Pfam-A 2-58 (75) alignment 
Range on Protein: 219-275
Range on HMM: 2-58/75.0
LGKPSKFMFECIQEKFDVNPQRTIMIGDRLNTDILLGKNCGLKTLAVLTGVTSEEEI
||||...|.. ..|.....|....||||.|.|||. ..|.|.... |||||..||. 
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedl