Gene AqueDSP-Un-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP002_AA protein Get Run
AqueP002_AA_80-231 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0044763 (Phosphotyrosine protein) phosphatases II 75-229 4.2e-32 106.6 In-house 14-172 (178) alignment 
Range on Protein: 75-229
Range on HMM: 14-172/178.0
HTSFYEMVDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSN---------SPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKkkceSNK
..  ... .||||  .|..|..|.... |.| .  |  ..||..          |  ... ||.|. . ..|... |||  ......|...|     ..|
glersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal....dek

GSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPsAKPNDGFLLQLLEYEGKLYN
|..|||. . |..||.....| |||. |..||. ....... | . ||.|.| ||.|.| .|..
ggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP19_pd Subfamily DSP19 82-226 7.2e-31 101.6 In-house 10-149 (152) alignment 
Range on Protein: 82-226
Range on HMM: 10-149/152.0
VDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKCesnkgSRVLVYSYFGLSRSA
....|.. .|..| | .....| |..|.|  .||..   . |  . ..|.|... |..|.||| .|...|||...|..|       .|||    | ||||
levgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskd.....gavlvHCnAGvSRsa

SVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGK
|| .|.|||.|  .||.. . .....|..|||.||. || ||| .
svviaylmkkeelsleealelvrearpcikPneGFikqLkeyeae
subfamily_DSP12_pd Subfamily DSP12 84-225 1.7e-29 97.2 In-house 2-141 (155) alignment 
Range on Protein: 84-225
Range on HMM: 2-141/155.0
ASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPV---TRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGLSRS
.|.|.. |..|. . |...|.|.   |  || . . ..|    ..  ...|.... |..|||.|  |....||...| ..     .  |||  ..|.|||
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealee.....egavlvHCqagvSRS

ASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
.....|.|||.|.. |||  . .|...|...||.||| ||  .| 
vtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfek
subfamily_Slingshot_pd Subfamily Slingshot 80-231 4.7e-29 94.9 In-house 15-161 (169) alignment 
Range on Protein: 80-231
Range on HMM: 15-161/169.0
EMVDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKkcesnKGSRVLVYSYFGLSR
 . .||.|  .. .| .    | | |..... ..||...       . .||. ... |..|.|||   ..  .|..||||     |||.|||.   |.||
qldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakk.....kgskvlvhckmGvsr

SASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNGK
|||. .|. ||| |..||......| .   .|||.||| || |||| |   |
sastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileask
subfamily_DSP14_pd Subfamily DSP14 82-237 4.9e-29 95.3 In-house 5-153 (157) alignment 
Range on Protein: 82-237
Range on HMM: 5-153/157.0
VDASEINTYLLIGnQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKkcesnKGSRVLVYSYFGLSRSA
   |.|. .| ..   .. . | |..|.|  ..|..   .  . ..||.  |..||. |..|   ..   | ....||     || ..||. . | ||||
aalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkk.....kggktlvhCvaGvSRSA

SVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNGKiSMRMQ
|.|.|.||| |  .|.......|.. |  .|| ||  || .|| ||.. . |..| 
slclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks.svkmv
subfamily_DSP1_pd Subfamily DSP1 76-228 1e-28 94.4 In-house 12-157 (163) alignment 
Range on Protein: 76-228
Range on HMM: 12-157/163.0
TSFYEMVDasEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYF
...|. |   .|  .| .| . .  |.|.|....|  .||.|..   | .|  |||..||||  ..|.  |... ..|....|||     . .||..   
lklydPve..kildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkk.....nGkvlihCqa

GLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
|.|||...|.|.|||.. ..||. ..  | . .  .|| || ||||.|| || 
GisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0048076 (Phosphotyrosine protein) phosphatases II 85-228 1.1e-28 95.1 In-house 5-143 (145) alignment 
Range on Protein: 85-228
Range on HMM: 5-143/145.0
SEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGLSRSASVC
|||  .| .|..|.... |.| .  |  ||||.. .  ..| ||.|  . ..| .. |||  |...|.|...| |.     | .|||. . |..|.....
seilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpvlVHCsaGvgRtgtlv

VAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
.|.||...|..||. ......|.| | ||.|.| .|.|.| .|.
aaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelell
PTPc_motif_SM00404 84-225 1.9e-28 94.1 In-house 2-139 (140) alignment 
Range on Protein: 84-225
Range on HMM: 2-139/140.0
ASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNS-PVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkceSNKGSRVLVYSYFGLSRSAS
 |.|  .| .|.... .| ..|. ..| .|.|.... ...    |.......|.|.....|.  |. .|||...|      .|| .|||. . |.||||.
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSat

VCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
...|.||......|..... .| . |. .|| .|. ||.||| 
liiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP10_pd Subfamily DSP10 79-230 3.6e-28 92.4 In-house 9-156 (159) alignment 
Range on Protein: 79-230
Range on HMM: 9-156/159.0
YEMVDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSN-SPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGL
.| ..||.. ..|..|..   .... | | .| .|||. . .|   . ....|| ....|  ...|    .. |.|...|.||     ||||||.   |.
ietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkk.....gsrvLvhCqaGi

SRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNG
||||.| .|.|||. . .|...... | . |   || .|. ||||.| .| . 
srsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
0048179 (Phosphotyrosine protein) phosphatases II 85-227 4.3e-27 90.0 In-house 5-144 (144) alignment 
Range on Protein: 85-227
Range on HMM: 5-144/144.0
SEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNS--PVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKkcesnKGSRVLVYSYFGLSRSAS
|||  .| .|..|.... |.| .  |  |.||...  |  ..| ||.|  . ..| .  |||  |...|.|...| .     .| .|||. . |..|...
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgt

VCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKL
...|.|||..|..||. ........| | ||.|.| .||||| .|
lvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
0049772 (Phosphotyrosine protein) phosphatases II 78-228 6.1e-27 90.6 In-house 100-274 (314) alignment 
Range on Protein: 78-228
Range on HMM: 100-274/314.0
F----------YEMVDASEINTYLLIG-----------------------------NQPSVENTEFLSrkrilfvlNLSNSPVPVTRDGIEYKSVKLEDd
|          ..||  ...|.  . .                             |.|.... |.|         .  ..|  ..| ||.|. . ..| 
freepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk........eelydpelferlgikylripvpD.

DEEDLLGVLQDCLDFLHKAkkkcesNKGSRVLVYSYFGLSRSAS-VCVAHLMKEEGWTLEKSWNHLKAQHPsAKPNDGFLLQLLEYEGKLY
....||  ....|.|...|      .||..|||    | .|... |..| |||  |..||. ........| ..||.||. ||..|| .|.
gsaplledfdeflefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefile
DSPc Dual specificity phosphatase, catalytic domain 93-224 7e-26 85.7 Pfam-A 3-131 (133) alignment 
Range on Protein: 93-224
Range on HMM: 3-131/133.0
IGNQPSVEnTEFLSRKRILFVLNLSNSPVP---VTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkceSNKGSRVLVYSYFGLSRSASVCVAHLM
.|.... .  ..|. . | .|.|....       .   ||| ....||..|...   |... .|..||      .|| .|||. . |.||||....|.||
lgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliiaYlm

KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYE
|.....|.. ....| . ..  ||.||| ||||||
ktknlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 93-224 7e-26 85.7 In-house 3-131 (133) alignment 
Range on Protein: 93-224
Range on HMM: 3-131/133.0
IGNQPSVEnTEFLSRKRILFVLNLSNSPVP---VTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkceSNKGSRVLVYSYFGLSRSASVCVAHLM
.|.... .  ..|. . | .|.|....       .   ||| ....||..|...   |... .|..||      .|| .|||. . |.||||....|.||
lgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliiaYlm

KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYE
|.....|.. ....| . ..  ||.||| ||||||
ktknlslneAyefvkerrskispnagflrqLleye
subfamily_DSP8_pd Subfamily DSP8 82-228 3.1e-25 82.6 In-house 13-155 (159) alignment 
Range on Protein: 82-228
Range on HMM: 13-155/159.0
VDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNS-PVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGLSRS
|.  .|  .| .| |  | . |.||.. | .|||.||| | . .    ..  | ..|. .|.|| ...  ..|. |||..      .||||. . | |||
vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkakse.....ngrvlvhvlaGisrs

ASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
|.| .|..||.   .|.......| . |. .||  || |||||| .| 
atvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
subfamily_DSP6_pd Subfamily DSP6 85-227 4.2e-25 82.1 In-house 15-154 (158) alignment 
Range on Protein: 85-227
Range on HMM: 15-154/158.0
SEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNS-PVPVTRDG-IEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGLSRSAS
 || ..| .|.. . .|.| |.. .| .|||. .  |     .| ..|. . .||  ...|   . . ..|. .|..|      | |||. . |.|||  
veilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearsk.....kskvlvhClaGisrsvt

VCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKL
|..|.|||..  .|..... .|.....  ||  |. |||..| .|
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0041856 (Phosphotyrosine protein) phosphatases II 83-230 2.5e-24 81.3 In-house 18-175 (182) alignment 
Range on Protein: 83-230
Range on HMM: 18-175/182.0
DASEINTYLLIGNQPS--------------VENTEFLSRKRILFVLNLSNSPV---PVTRDGIEYKSVKLEDDDEEDllgvLQDCLDFLHKAKKkcesnK
| ..|| .|..|..|.               .. ..| . .|  ..||.. .     ..| ||.|. .  .|..  |    |...|||......     .
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevle.....e

GSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHP--SAKPNDGFLLQLLEYEGKLYNG
| .|||    |..|......| |||. |..||. ..... . |     || .|.|||...| .|.. 
ggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_DSP15_pd Subfamily DSP15 85-225 3.3e-24 79.7 In-house 3-137 (151) alignment 
Range on Protein: 85-225
Range on HMM: 3-137/151.0
SEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDgIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGSRVLVYSYFGLSRSASVC
|.. . | .||    ...| |..|.|  .|...... .. .| |||| ....|  . .| ...... .|.||.. |     .  |||.   |.|||. ..
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlk.....eenvlvhClaGvsRsvtlv

VAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
||.||       ... . .||.  .|.|| ||  || ||| 
vaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek
subfamily_MKPLT_pd Subfamily MKPLT 88-225 9.7e-23 74.5 In-house 26-158 (164) alignment 
Range on Protein: 88-225
Range on HMM: 26-158/164.0
NTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkceSNKGSRVLVYSYFGLSRSASVCVAH
.  |  ||   ..| . |    |  ..|.|.         .||  ||.||  .| |   |.   .|| .|      . | ||||.   | |||.|| || 
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakflada.....idsGGrvlvhcvqGksrsssvtvaf

LMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
|.| .||||......|| .   ..|| ||| || ..| 
LikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 88-225 9.7e-23 74.5 In-house 26-158 (164) alignment 
Range on Protein: 88-225
Range on HMM: 26-158/164.0
NTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkceSNKGSRVLVYSYFGLSRSASVCVAH
.  |  ||   ..| . |    |  ..|.|.         .||  ||.||  .| |   |.   .|| .|      . | ||||.   | |||.|| || 
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakflada.....idsGGrvlvhcvqGksrsssvtvaf

LMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
|.| .||||......|| .   ..|| ||| || ..| 
LikskgwtlkeayeylkerrsivapnrGflkqlakfee
0043147 (Phosphotyrosine protein) phosphatases II 89-228 4.3e-21 70.8 In-house 24-161 (172) alignment 
Range on Protein: 89-228
Range on HMM: 24-161/172.0
TYLLIGNQPSVENTEFLSRKRILFVLNLSNS---PVPVTRDGIEYKSVKLEDDDEEdLLGVLQDCLDFLHKAKkkcESNKGSRVLVYSYFGLSRSASVCV
 ..  .. .  .. ..| .. |  ..|| .    | ...| ||.|  .  .| .   || .|...|.|....      ..| .|||  . |..|.. ...
atqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidell...alspggpvlVHCsaGvgRtgtlva

AHLMKeEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
|.||. .|..||.  ...... | | .|.... .|...| .|.
aylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 85-224 9.8e-21 67.8 In-house 8-144 (148) alignment 
Range on Protein: 85-224
Range on HMM: 8-144/148.0
SEI-NTYLLIGNQPSVENTEFLSRKRILFVLNLSNS-PVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKkkcesNKGSRVLVYSYFGLSRSAS
||| ...| .|...|  . | |    .  . | ... . ..   ||||  |.|.|...|||  . .|  .|..|||     ..| ||||    | |||. 
seikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkak.....deGrrvLvhlqmGvsrssa

VCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYE
. ...|.. .  .|..  .  | . .  .|| ||| || |.|
lallwlidfkrvslkealalvkskrryvdpnlgfLkqLaele
0036282 (Phosphotyrosine protein) phosphatases II 81-227 5.4e-19 64.0 In-house 9-169 (174) alignment 
Range on Protein: 81-227
Range on HMM: 9-169/174.0
MVDASEINTYLLIGNQPSVeNTEFLSRKRILFVLNLSNSPVPV---------------TRDGIEYKSVKLEDDDEEDLLGvLQDCLDFLHKAKKKcesNK
 .| |.|...|..|. |   . |.| . .|  |..| ..  .                .| ||.|. .  .|. . ||   |.....|...| ..   ..
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse...dp

GSRVLVYSYFGLSRSASVCVAHLMKEEGW-TLEKSWNHLKAQH---PSAKPNDGFLLQLLEYEGKL
|  |||    |..|.. ...| ||.  .. .|.. ........   | . ...... .| ..| .|
ggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0042113 (Phosphotyrosine protein) phosphatases II 81-226 6.5e-19 63.8 In-house 44-241 (245) alignment 
Range on Protein: 81-226
Range on HMM: 44-241/245.0
MVDASEINTYLLIGNQPSVENTE----FLSRKRILFVLNLSNS----------------------------------------------PVPVTRDGIEY
.|| ..|.  ......|. |..|    .| . .|  ...|..                                               . . .| .| |
yvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihy

KSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesNKGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEG
  .  .|... |||  |.|.|.|..|| ..   ... .||| .  |..|.. ...| ||     || |..||.   .|. | | | ...... .| |.. 
hylpwpdhgvpdllellldflefvrkalae...dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

K
.
e
0046846 (Phosphotyrosine protein) phosphatases II 80-228 6.6e-19 63.8 In-house 8-173 (176) alignment 
Range on Protein: 80-228
Range on HMM: 8-173/176.0
EMVDASEINTYLLIGNQP----------SVENTEFLSRKRILFVLNLSNS-----------PVPVTRDGIEYKSVKLEDDDEEDLlGVLQDCLDFLHKAK
.  | ..|| .|..|. |            .. |.| . .|  |.|| .            .  ... ||.|. .  .| .  ||   |...|.|...| 
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal

KKcesnkGSRVLVYSYFGLSRSASVCVAHLMKE-EGWTLEKSWNHLKAQHP-SAKPNDGFLLQLLEYEGKLY
|.     | .|||  . |..|.. ...| |..   |...|.   ....|.|  | ...... .| |.| .|.
ke.....ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_DSP3_pd Subfamily DSP3 80-229 7.7e-19 61.9 In-house 7-159 (162) alignment 
Range on Protein: 80-229
Range on HMM: 7-159/162.0
EMVDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSNSPV-PV-------TRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesnKGSRVLV
.. .. |.   | .|.. . .. . | .  |  ||| ... .  |       .  .|.|  ....|  | ||    .   .|...| ..    | ..|||
lskevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsq....kegkvlv

YSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHpSAKPNDGFLLQLLEYEGKLYN
 .  |.|||| . .|.||  .  || .  .. ...  .  ||.||| || |.. .| .
hcvvGvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkr
subfamily_STYXL1_pd Subfamily STYXL1 127-228 2.6e-18 59.7 In-house 58-154 (157) alignment 
Range on Protein: 127-228
Range on HMM: 58-154/157.0
GIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKkcesnKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGK
  .   ...||..| |||  |..  .|..| ||     .|. |||.|  |.||||.| .|.|| .. .||.|....||  ..  ||| .|. || |.| .
vakllhiavedeneadllerlkeavqfiekhkk.....egevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq

LY
|.
ll
0051082 (Phosphotyrosine protein) phosphatases II 81-223 3.2e-18 61.2 In-house 5-149 (151) alignment 
Range on Protein: 81-223
Range on HMM: 5-149/151.0
MVDASEINTYLLIGNQPSVENTEFLSRKRILFVLNLSN------SPVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKkcesNKGSRVLVYSY
. ..| .  .|.....|. .. |.| .  |  ..|| .       | .... |||.. . ..|... .|   .. .|.||... .    .|.  |||.  
yinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld....kkngpvlvHCs

FGLSRSASVCVAHLMKeEGWTLEKSWNHLKAQHP-SAKPNDGFLLQLLEY
 |..|.. .... ||. .|..||. ........| .  ||..||.||...
aGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0037934 (Phosphotyrosine protein) phosphatases II 77-227 6.1e-18 60.7 In-house 32-241 (243) alignment 
Range on Protein: 77-227
Range on HMM: 32-241/243.0
SFYEMVDASEINTYLLIGNQPSVE--------NTEFLSRKRILFVLNLSNSP---------------------------------------------VPV
| |   . ...  .| ....|  |        . ..| . .|  ...| .                                                ..
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

TRDGIEYKSVKLED----DDEEDLLGVLQDCLDFLHKAKKKCESNKGSRVLVYSYFGLSRSASVCVAHLMKEE-GWTLEKSWNHLKAQHPS-AKPNDGFL
|| .| |  .   |    |. ||||  |... .|....      ..|..|||  . |..|.. ...| ||..  |..||. ...|..| |  | .. ...
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy

LQLLEYEGKL
 .| |.. .|
rflyeallel
0040439 (Phosphotyrosine protein) phosphatases II 103-228 1.8e-17 59.2 In-house 72-246 (249) alignment 
Range on Protein: 103-228
Range on HMM: 72-246/249.0
EFLSRKRILFVLNLSNSPVP-------------------------------------------VTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKK
..| . .|  ...|..   .                                            . . .... .   |  . ..   ..|.|||.....|
rmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrk

KCESN-KGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
 .|.. ||..||| .  |..|.. ...| ||     || |..||  ...|. | | | .|.... .|.|.. .|.
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 78-229 2e-17 59.0 In-house 16-273 (278) alignment 
Range on Protein: 78-229
Range on HMM: 16-273/278.0
FYEMVDASEINTYLLIGNQP-----------------------------------------SVENTEFLSRKRILFVLNLSNS-----------------
.. . . |||...|..||..                                            . ..|   .|  ...| .                  
llllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

---------------------------------PVPVTRDGIEYKSVKLEDDDEEDLL--GVLQDCLDFLHKAKKKCESN---------KGSRVLVYSYF
                                 .   .|    .. .  .| .  .|     ....|.|...| |.  |          .| .|||  . 
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GLSRSASVCVAHLMKEE---GWTLEKSWNHLKAQHPS-AKPNDGFLLQLLEYEGKLYN
|..|.. ...|.||.|    |..|..  ..|. | |  | .| ... .| |.. .|..
GvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0049260 (Phosphotyrosine protein) phosphatases II 91-227 3.5e-17 57.9 In-house 15-149 (152) alignment 
Range on Protein: 91-227
Range on HMM: 15-149/152.0
LLIGNQPSVENTEFLSRKRILFVLNLSNSP---VPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAkkkcESNKGSRVLVYSYFGLSRSASVCVAH
. .|...  .. ..| .  |  ...| .      . .  .|.|. .  .|.   ||  .|...|.|..|.      .|| .|||  . |..|.. ...| 
qgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl....aldkggpvlVHCsaGvgRtgtlvaay

LMKeEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKL
||.  |..||.  ...... | | || |.| .|.|.|..|
lml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 87-227 4e-17 56.0 In-house 6-152 (154) alignment 
Range on Protein: 87-227
Range on HMM: 6-152/154.0
INTYLLIGNQPSVENTEFLSRKRILFVLNL-SNSPVPVTR------DG--IEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKCESNKgsrVLVYSYFGL
  ..| |. . .  |   |  |.|  .||    ..   |       ||  |||  ..| || . |..  |. ...|...|    | ||   |||.|  |.
eaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennk...vlvhsdkGv

SRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKL
||||.. ...||..   .| ..   ||   .  ||| ||| ||  .| .|
srsaallisylmdklkislslalellkdsryiikPnqGflkqleifekel
0045450 (Phosphotyrosine protein) phosphatases II 105-229 1.1e-16 56.9 In-house 127-305 (307) alignment 
Range on Protein: 105-229
Range on HMM: 127-305/307.0
LSRKRILFVLNLSNSP-------------------------------VpvtRDGIEYKSVKLEDD-----------------DEEDLLGVLQDCLDFLHK
| ....  ...|...                                .    ||. .  ....|                   . ..   ....|||...
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh...ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

AKKKCESN-KGSRVLVYSYFGLSRSASVCVAHLMKEEG--------WTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYN
..| .|.. ||..||| .  |..|......| ||.. .        ..|.. ...|..| | | .| ... .| |.. .|..
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0040438 (Phosphotyrosine protein) phosphatases II 112-228 2.9e-16 55.1 In-house 113-276 (317) alignment 
Range on Protein: 112-228
Range on HMM: 113-276/317.0
FVLNLSNSPVP---------------------------VTRDGIEYKSVKLEDD----------------DEEDLLGVLQDCLDFLHKAKKKCEsNKGSR
 ...| ..  .                           .. .||..  ...||.                .. ..   ....||||.......| ..|. 
vivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggp

VLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
||| .  |..|......| ||     ||.|...|. ...|..| | | .. ... .| ... ...
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
PTEN_1 70-229 6.7e-16 53.7 In-house 27-193 (196) alignment 
Range on Protein: 70-229
Range on HMM: 27-193/196.0
SRLSKHTSFYEMV--DasEINTYLLIGNQPSV-ENTEFLSRKRILFVLNLSNSPVP---------VTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKA
||........ .   .  ||   |..|....| .. . |  . | .|.|||. .             . |.||...  ||.   .|  ..  | .| . .
sriiamgkapsrpllq..eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewl

KKKCEsnkGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYN
... .   |  |||.   ||.||. |. | ||. ...| .. . ..... | . || ... .||||. .| .
lsdpn...gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
subfamily_LRR-DSP_pd Subfamily LRR-DSP 84-230 3.3e-15 49.9 In-house 120-261 (263) alignment 
Range on Protein: 84-230
Range on HMM: 120-261/263.0
ASEINTYLLIGNQPSVENTEFLSRKRILFV-LNLSNSpVPVTRDGIEYKSV-KLEDDDEEDLLGVLQDCLDFLHKAKKKcesnkGsRVLVYSYFGLSRSA
 .||   | .| . |  |  .|  . .  . | ...   |.  .   | |. ..|| || |.   ...   |... .||     |  |||.   |.|||.
PdeiidklflGgldsannksilkdlgvthillavadf.ePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkk.....G.GvlvhcraGvsrss

SVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNG
.. ...||| .  ..... .  . . |  .|| ||. ||. || ||.  
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfct
0039614 (Phosphotyrosine protein) phosphatases II 112-230 1e-14 50.2 In-house 128-291 (297) alignment 
Range on Protein: 112-230
Range on HMM: 128-291/297.0
FVLNLSNSPVP-------------------------VTRDGIE-----------------YKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKCesNKGSRV
 ...| .                              ..||.                  .  ..  |..  ..| .|.. |.....| ...  .|| .|
vivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael..pkggpv

LVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNG
|| .  |..|......| ||     || |..... ...|. | | | ...... .| ... .|.. 
lVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0036941 (Phosphotyrosine protein) phosphatases II 142-231 5.6e-14 47.6 In-house 182-280 (297) alignment 
Range on Protein: 142-231
Range on HMM: 182-280/297.0
DLLGVLQDCLDFLHKAKKKCESN-KGSRVLVYSYFGLSRSASVCVAHLM--------KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLYNGK
..    ...|||.....|...   .|..||| .  |..||.....| ||        ||.|... . ...|. | | | .. .....| |.. .|.. |
gvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0051429 (Phosphotyrosine protein) phosphatases II 89-235 1.1e-13 47.0 In-house 22-232 (272) alignment 
Range on Protein: 89-235
Range on HMM: 22-232/272.0
TYLLIGNQP---SVENTEFLSRKRILFVLNLSNSP------VPVTRDGIEYKSVKLEDDDEEDLLGVL--------------------------------
 .|. ...|   .... ..| . .|  ...| .        ..    ||.|  . ..||.... |                                   
grlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------QDCLDFLHKAKKkcesnkGSRVLVYSYFGLSRSASVCVAHLMKeEGWT--------------LEKSWNHLKAQHPSAKPNDGFL
                . .|..|.   .      | .|||  . | .|.. |... |.  .|..              ||. ...|.|| | | ......
vmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

LQLLEYEGKLYNGKISMR
|.|.|.. .|... .|.|
lflyeallellrsllsvr
0043336 (Phosphotyrosine protein) phosphatases II 109-224 6.9e-13 44.1 In-house 157-273 (278) alignment 
Range on Protein: 109-224
Range on HMM: 157-273/278.0
RILFVLNLSNSPVPVTRDGIEYKSVKLEDDDEEDllgVLQDCLDFLHKAKKKCEsNKGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHL
 ....|...|   . .| .  |  ..  |..  .    |.. ||||.......| .... ||| .  |..|.. .... |.     || |..||. ...|
ytvrtlevtnlgdgesrtvthyhylgwpdhgvpe...slsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

KAQHPSAKPNDGFLLQLLEYE
. | |.| ... .. .| |..
reqRpgavqtpsqyrflyeal
subfamily_MSG5_pd Subfamily MSG5 163-227 7.8e-13 41.9 In-house 96-160 (165) alignment 
Range on Protein: 163-227
Range on HMM: 96-160/165.0
SNKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKL
  |. ..||.   |||||||. ||..||  . .|......||..    .|. |...||.|.|  |
tskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
0038934 (Phosphotyrosine protein) phosphatases II 105-230 1.5e-12 43.0 In-house 52-179 (194) alignment 
Range on Protein: 105-230
Range on HMM: 52-179/194.0
LSRKRILFVLNLSNS-----PVPVTRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKKKcesNKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKS
|  ...  |..|.|.     |  ... |||| .   .|| .   | .|.. ||....  ..   ..|  |.|  . ||.|.. ...|.|..  |...|..
llnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne...dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeA

WNHLKAQHPSAKPNDGFLLQLLEYEGKLYNG
 ....   |.| || ..| .||.. . |...
ialfrekRpgaipnqdyleallkrykelrka
subfamily_STYX_pd Subfamily STYX 163-236 1e-10 35.0 In-house 93-165 (166) alignment 
Range on Protein: 163-236
Range on HMM: 93-165/166.0
SNKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGkLYNGKISMRM
 .|| .|||.   |.||||.. .|..|.  |    ... ... .    .||.||  || |||  .|  |.....
lqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea.iylakltikl
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 132-228 8.5e-10 31.9 In-house 51-142 (145) alignment 
Range on Protein: 132-228
Range on HMM: 51-142/145.0
SVKLEDDDEEDLLGVLQDCLDFLHKAKkkcesNKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEYEGKLY
 .  || .  ||   ...  ||. | |     ..|. |.|.   |.||| .| || |||  . || ..   ....   | ||  || .||. | .| 
litaedlesydlsqhfdevtdfidkgk.....eegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlk
0047943 (Phosphotyrosine protein) phosphatases II 147-221 9.9e-10 33.8 In-house 185-265 (273) alignment 
Range on Protein: 147-221
Range on HMM: 185-265/273.0
LQDCLDFLHKAKKKCESN-KGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLL
|...|.|.....|..|.. ... |.| .  |..|........|.     || |..... ...|. | | . ..  ....| 
lesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0051299 (Phosphotyrosine protein) phosphatases II 146-214 5.6e-08 28.1 In-house 200-272 (288) alignment 
Range on Protein: 146-214
Range on HMM: 200-272/288.0
VLQDCLDFLHKAKKKCEsNKGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPND
 ....||||....|... ..|. |.| .  |..|.. .... |.     ||.|..... ...|. | | . .. 
spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_PTPMT1_pd Subfamily PTPMT1 124-224 5.8e-08 27.4 In-house 70-165 (171) alignment 
Range on Protein: 124-224
Range on HMM: 70-165/171.0
TRDGIEYKSVKLEDDDEEDLLGVLQDCLDFLHKAKkkcesNKGSRVLVYSYFGLSRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKPNDGFLLQLLEY
.. |.|. ...  |  |.  |  |.. ..|..| .     .||.|| |    | .|||..  ..|||.| ...|. ...||.. .  . ..  . .| ||
kklgveqlqlatvDfteapdleklekgvefiekva.....skgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqey

E
|
e
0050432 (Phosphotyrosine protein) phosphatases II 147-213 8.8e-08 27.3 In-house 216-284 (308) alignment 
Range on Protein: 147-213
Range on HMM: 216-284/308.0
LQDCLDFLHKAKKKCesnKGSRVLVYSYFGLSRSASVCVAHLM-----KEEGWTLEKSWNHLKAQHPSAKPN
....||||....|..   .|. ..| .  |..|.. .... |.     || |..... ...|. | | . ..
peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
0046845 (Phosphotyrosine protein) phosphatases II 148-211 4.1e-07 25.1 In-house 185-257 (284) alignment 
Range on Protein: 148-211
Range on HMM: 185-257/284.0
QDCLDFLHKAKKKCES-NKGSRVLVYSYFGLSRSASVCVAHLMKEE--------GWTLEKSWNHLKAQHPSAK
.| |.||..... .|. ..|. ..| .  |..|.. .....|..|         |..... ...|. | | . 
edlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmv
0048567 (Phosphotyrosine protein) phosphatases II 151-212 5.3e-07 24.1 In-house 57-123 (157) alignment 
Range on Protein: 151-212
Range on HMM: 57-123/157.0
LDFLHKAKKKCE--SNKGSRVLVYSYFGL---SRSASVCVAHLMKEEGWTLEKSWNHLKAQHPSAKP
 .| .|..|...  ...| .. |....||   .|.| .. ..|..  |.| |. ...|.  .|. .|
yrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp