Gene AqueDSP-Un-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP003_AA protein Get Run
AqueP003_AA_71-226 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0044763 (Phosphotyrosine protein) phosphatases II 78-223 8.5e-28 92.6 In-house 28-168 (178) alignment 
Range on Protein: 78-223
Range on HMM: 28-168/178.0
GGLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKYLTAVQEARDilkINFLELNWEDTETWLiPDSDIRTLCNYIQTGLDMQGQSVFVHCAQGKSR
.|||||..  . . ..|.| ..||||| .. || . .|..    |  .   |..| ....|  .    .. .. ....|.. || .|  |.|||  |..|
pglylgslppaddlellkelgithivnlteelelgflkcdpywpeeag...iqylhipipDhgvpd.llehflefvefieealdekggpvlVHCsaGvgR

SSTAVVAYVMVAKGLSLKESLGLVQSLHKmAEPNPHFMKRLEEFEK
| | |.|| |   |||| | . ||..    . |||.... |.|||.
sgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefel
subfamily_DSP12_pd Subfamily DSP12 78-225 1.4e-26 87.8 In-house 7-143 (155) alignment 
Range on Protein: 78-225
Range on HMM: 7-143/155.0
GGLYLGGFRGVINTQFLREANVTHIVNTAKGlEIfgPKYLTAVQEARdILKINFLELNWEDTETWlipdsdIRTLCNYIQTGLdMQGQSVFVHCAQGKSR
.|||||| . |.....|.|...||..  .|  |.  |.. .  .. .  ..|. |  . ||  ..      . . ...|. .|  ....|.|||. | ||
pglylggleavqeeellkelkithvlsvike.el..pehklkkgkvs.tkfiqilDepeediLsh......ldeavdFieeal.eeegavlvHCqagvSR

SSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSE
|.|.|.||.|  ..|||.. | ||.. .. .|||  |.. |  |||. 
SvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
0048179 (Phosphotyrosine protein) phosphatases II 78-223 6.7e-26 86.1 In-house 9-142 (144) alignment 
Range on Protein: 78-223
Range on HMM: 9-142/144.0
GGLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKYLtavqeardilKINFLELNWEDTETWLIPdSDIRTLCNYIQTGLDmQGQSVFVHCAQGKSR
.|||||..  ... ..|.. ..|...| . . |   ..             |..| |.|.| ..  .. .........|.. |. .|  |.|||  |..|
pglylgslptaldlellkklgittvinlteeyepeflere..........giqylhlpwpDhgvpdll.ellleflefieeale.eggpvlVHCsaGvgR

SSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
. | |.||.|. .||||.| | ||.| . .| |||.... |.|.||
tgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 78-223 1.9e-25 84.7 In-house 9-140 (145) alignment 
Range on Protein: 78-223
Range on HMM: 9-140/145.0
GGLYLGGFRGVINTQFLREANVTHIVNTakgleifgpkylTAVQEARDILKINFLELNWEDTETWLIPdSDIRTLCNYIQTGLDmQGQSVFVHCAQGKSR
.|||||..  ... ..|.. ..|...|             |  .|    | |..| |.|.| ..  .. .........|.. |. .|  |.|||  |..|
pglylgslptaldlellkdlgittvlnl............tselellerlgiqylylpwpDhgvpdll.ellleflefieealk.eggpvlVHCsaGvgR

SSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
. | |.||.|  .|.|| | | ||.| . .| |||.... |.|||.
tgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefel
0049772 (Phosphotyrosine protein) phosphatases II 72-225 4.1e-23 78.0 In-house 148-273 (314) alignment 
Range on Protein: 72-225
Range on HMM: 148-273/314.0
LTTSSGGGlylgGFRGVINTQFLReanvthivntakgleifgpkylTAVQ--EARDILKINFLELNWEDtETWLiPDSDIRTLCNYIQTGldMQGQSVFV
|.. .|.|    ..  . . ..|.                      . .   |    | |..| ....| ...  ...|.. ....|..    .|  |.|
llildgng....neptaadlellk......................eelydpelferlgikylripvpD.gsap.lledfdeflefieea..dkggpvlv

HCAQGKSRSST-AVVAYVMVAKGLSLKESLGLVQSLHKmAEPNPHFMKRLEEFEKSE
||. ||.|. | .|.||.| . |.||.| |  |.. .  . |||.|.. ||..|. .
HCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
subfamily_DSP15_pd Subfamily DSP15 79-234 5.8e-23 75.7 In-house 8-147 (151) alignment 
Range on Protein: 79-234
Range on HMM: 8-147/151.0
GLYLGGFRGVINTQFLREANVTHIVNTAKgleifgpkyltavqEARDILK-INFLELNWEDTETWLIpDSDIRTLCNYIQTgLDMQGQSVFVHCAQGKSR
|||||.||   ... |.| |.|||..                 .|. .|| |... .. .||    . .. ..   ..| .   .....|.|||. | ||
glylgnfrdskdeelLkeknithilsvhd..............nakkllkdieYkciaasDtpsakl.skffkesvefihk.cRlkeenvlvhClaGvsR

SSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSELlQELRQAI
| | ||||.| .  |. ...|  ..    .|.||  | . |.|.||..| .|.|. .
svtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektkl.keyrkql
PTPc_motif_SM00404 78-223 6e-23 76.3 In-house 7-139 (140) alignment 
Range on Protein: 78-223
Range on HMM: 7-139/140.0
GGLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFgpkyltavqeaRDILKINFLELNWEDTETWLIpDSDIRTLCNYIQTGlDMQGQSVFVHCAQGKSR
..||||. .  .| ..| . ..||..| ..  ..            .   ....|... .|.|.  .   ... . ..|..    .|..|.|||. | ||
phlylgskskaqnpallkklgithvinvteevslt...........kensgfqilqiplddnekdkl.skyldkvldfiena.ekkggkvlVHCqaGvSR

SSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
| | ..||.|  ..|||.|.. .|..  .. .|| .|.. | |.||
SatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP19_pd Subfamily DSP19 79-224 8e-23 75.5 In-house 18-149 (152) alignment 
Range on Protein: 79-224
Range on HMM: 18-149/152.0
GLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKYLTavqeardILKINFLELNWEDTETWlipdsdIRTLCNYIQTGLDMQgQSVFVHCAQGKSRS
 ||||   .. ... |.| ..|||.| | |.. . || .|       .|.|. |.|. .|  ..      ...  ..|. ... .   |.|||  | |||
rlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdft.......ylsieilDlpetdllsy......lkealdFieearskd.gavlvHCnAGvSRs

STAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKS
.. |.||.|  . |||.|.| ||.. .. ..||  |.| |.|.|..
asvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeae
subfamily_DSP3_pd Subfamily DSP3 79-224 2.4e-22 73.3 In-house 17-156 (162) alignment 
Range on Protein: 79-224
Range on HMM: 17-156/162.0
GLYLGGFRGVINTQFLREANVTHIVNTAKGlEIFGpkyLTAVQEARDILKINFLELNWEDTETWLIpDSDIRTLCNYIQTGLDMQGQSVFVHCAQGKSRS
.||.|.     . . |... .||..|.|.| ...      . .|  . |.|..| |. .|. .  . .   .|  ..|.. |. .   |.|||..| |||
klyvgdeavakdkskLkklGithvlnaaeg.rfsk...vdtgaefykdleikylGlevdDvpefdl.skyFetaakfidealsqkegkvlvhcvvGvsRs

STAVVAYVMVAKGLSLKESLGLVQSlHKMAEPNPHFMKRLEEFEKS
.| |.||.|. . ..|.| .  |.. ...  ||  |.| | |....
atlvlayLmirrkmtlveairtvrk.kReilPneGFlkqLaeldee
subfamily_DSP1_pd Subfamily DSP1 80-228 1.2e-21 71.4 In-house 25-159 (163) alignment 
Range on Protein: 80-228
Range on HMM: 25-159/163.0
LYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKyltavqeardilKINFLELNWEDTETWLIpDSDIRTLCNYIQTGLDMQGQsVFVHCAQGKSRSS
||||.     |...|.. ..|.|.| .| |. . ..              .. .|. ||...  |  . ...  ..|..  ...|. |..||..| ||||
LylGsetvasnleiLkslgitailnvskeldnvfed............lfeYkklkleDspkadi.slvfeeviefidevkkknGk.vlihCqaGisRss

TAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSELLQ
| ..||.|  | .||.|   .|..  .. .||  |...| ..||..||.
tlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
0043147 (Phosphotyrosine protein) phosphatases II 80-224 1.8e-20 68.8 In-house 26-159 (172) alignment 
Range on Protein: 80-224
Range on HMM: 26-159/172.0
LYLGGFRGVINTQFLREANVTHIVNTAKGleifgpkylTAVQEARDILKINFLELNWEDTETWliPDSDIRTLCNYIQT-GLDMQGQSVFVHCAQGKSRS
......    . ..|.| ..|||||  .          .   |    | | .| |.|.|  .   . . .. ....|..  .  .|  | |||  |..|.
qgplrntladfwrmlkelgithivnltel.........lydpellerlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRt

STAVVAYVMVaKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKS
 | |.|| |  .|||| | . ||..   .| .||.... | .||| 
gtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekl
0041856 (Phosphotyrosine protein) phosphatases II 79-224 2.5e-20 68.3 In-house 25-171 (182) alignment 
Range on Protein: 79-224
Range on HMM: 25-171/182.0
GLYLGGFRG--------------VINTQFLREANVTHIVNTAkgleifGPKYLTavqEARDILKINFLELNWEDTETWLipdsdIRTLCNYIQTGLDmQG
.||||....                . ..|.| ..|.||| .      .. |     |    | |..| |.|.| ..       ...|...|.. |. .|
nlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp...ellerlgiqylylpwpDhgvpd.....ldelldfieevle.eg

QSVFVHCAQGKSRSSTAVVAYVMVAKGLSLKESLGLVQSLHK--MAEPNPHFMKRLEEFEKS
  |.|||  |..|. | |.||.|  .|.|| | . ||.|        || .|. .| ..|. 
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_DSP14_pd Subfamily DSP14 79-224 3.7e-20 66.5 In-house 13-143 (157) alignment 
Range on Protein: 79-224
Range on HMM: 13-143/157.0
GLYLGgFRGVINTQFLREANVTHIVNTAKgleifgpkyltAVQEaRDILKINFLELNWEDTETWLIPDsDIRTLCNYIQTgLDMQGQSVFVHCAQGKSRS
 |.|.  ..... . |.....|.|.| .             ... ... .|. ...  ||...  . .    . ...|.. ....|  . |||. | |||
sLfls.gvaalskellkkkkitliinvtv...........elpn.tklkdiervkvpveDnpeaklak.hfdevadkiee.vkkkggktlvhCvaGvSRS

STAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKS
 . ..||.|  . |||.|.  ||.|   . .||  | |.| ..|| 
AslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkk
DSPc Dual specificity phosphatase, catalytic domain 80-223 8.7e-20 65.9 Pfam-A 1-132 (133) alignment 
Range on Protein: 80-223
Range on HMM: 1-132/133.0
LYLGGFRGVInTQFLREANVTHIVNTAKGLEIFgpkyltavqEARDILKINFLELNWEDTETWLIPdSDIRTLCNYIQtGLDMQGQSVFVHCAQGKSRSS
||||.       ..| . ..|...| .|  .            |.   .|..|..  ||...  |  .... . ..|.  .. .|..|.|||. | ||| 
lylgskstas.lalleklgitlvinvtkevpnn.........naikkseieylripvedetetkis.keleeavefie.kaeqkgkkvlVHCqaGisRSa

TAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
| ..|| |  |.|||.| . .|..  ..  || .|.. | |.|.
tliiaYlmktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 80-223 8.7e-20 65.9 In-house 1-132 (133) alignment 
Range on Protein: 80-223
Range on HMM: 1-132/133.0
LYLGGFRGVInTQFLREANVTHIVNTAKGLEIFgpkyltavqEARDILKINFLELNWEDTETWLIPdSDIRTLCNYIQtGLDMQGQSVFVHCAQGKSRSS
||||.       ..| . ..|...| .|  .            |.   .|..|..  ||...  |  .... . ..|.  .. .|..|.|||. | ||| 
lylgskstas.lalleklgitlvinvtkevpnn.........naikkseieylripvedetetkis.keleeavefie.kaeqkgkkvlVHCqaGisRSa

TAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
| ..|| |  |.|||.| . .|..  ..  || .|.. | |.|.
tliiaYlmktknlslneAyefvkerrskispnagflrqLleyer
0046846 (Phosphotyrosine protein) phosphatases II 78-223 1.2e-19 66.2 In-house 17-170 (176) alignment 
Range on Protein: 78-223
Range on HMM: 17-170/176.0
GGLYLGGFR----------GVINTQFLREANVTHIVNTAKGLEIFGPKYLTAVQEARDIlKINFLELNWEDTETWLIpdSDIRTLCNYIQTGLDmQGQSV
..|.||..              . ..|.|...|..||  .  |.   |  .  .| ..  .| .| |.|.|  .  .  ... .|...|.. |. .|. |
anlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpelekl.giqylhlpwpDhgvpdl..elllellefirealk.eggpv

FVHCAQGKSRSSTAVVAYVMVA-KGLSLKESLGLVQSLHK-MAEPNPHFMKRLEEFEK
 |||  |..|. | |.|| .   ||||. | | ||.. .  .| ..|.... |.|||.
lVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 80-225 1.6e-19 63.7 In-house 10-152 (154) alignment 
Range on Protein: 80-225
Range on HMM: 10-152/154.0
LYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKYLTavqEARDILKINFLELNWEDTETWLIPDSdIRTLCNYIQTGL-DMQGQSVFVHCAQGKSRS
||.. |   .|   |.. |...|.| . | .   ..  .   .  | . |..|.|.  |     | .. .    ..|.  .  .. . |.||. .| |||
lyissfdaalnkldlqlkniksilnvgiGinnlftdens...dindgfiieylnlelfddvnfdiiek.ldkafefiddaiggvennkvlvhsdkGvsrs

STAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSE
.. ...|.|  . .|| ..| |...   . .||  |.|.|| |||  
aallisylmdklkislslalellkdsryiikPnqGflkqleifekel
subfamily_LRR-DSP_pd Subfamily LRR-DSP 79-224 4.2e-19 62.7 In-house 126-257 (263) alignment 
Range on Protein: 79-224
Range on HMM: 126-257/263.0
GLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKYLT--AVQEARDILKINFLElNWEDTETwlipdsdirtlcnYIQTGLDMQGqsVFVHCAQGKS
.|.|||     |  .|.. .||||. .   .| . || .   ......|. . .     .|.|..             .|. | .  |  |.|||  | |
klflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisq.hfeetna.............fieeGrkkGG..vlvhcraGvs

RSSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKS
||||.|..|.|  . | .||.| ||..      ||| |...|  .|| 
rsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekk
0049260 (Phosphotyrosine protein) phosphatases II 79-223 7.4e-19 63.4 In-house 14-147 (152) alignment 
Range on Protein: 79-223
Range on HMM: 14-147/152.0
GLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKY---LtavqeardilkiNFLELNWEDTETWLIPDSDIRTLCNYIQTgLDMQGQSVFVHCAQGK
....|.     . ..|.| ..|.||.  . ||.  .|                 ..| |.|.|  .. ...  .  |    .  .  .|  |.|||  |.
tqgpgpntladfwrmlkelgittivmltellelgklkceqyi............qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGv

SRSSTAVVAYVMVaKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
.|. | |.|| |  .|.||.| . ||..  ..| |||.... | ||||
gRtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 78-225 1.2e-18 61.0 In-house 13-147 (148) alignment 
Range on Protein: 78-225
Range on HMM: 13-147/148.0
GGLYLGGFRGVINTQFLREANVTHIVNTAKGLE-IFGPKyltavqeardilKINFLELNWEDTETWLIpDSDIRTLCNYIQTgLDMQGQSVFVHCAQGKS
. |.||  .   . . |.. .||.|||..|  . ..  .             |..|... .| .   .  .   .. ....     .|. | ||.  | |
afLFlGskksaadlealkalgvtrivnatkerdnaldqr............gieYlhvaldDkpkedl.saiFediiafvrk.akdeGrrvLvhlqmGvs

RSSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSE
|||  ......  |  |||| | ||.|  .. .||. |.| | |.|..|
rssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqae
0036282 (Phosphotyrosine protein) phosphatases II 78-223 1.8e-18 62.3 In-house 17-167 (174) alignment 
Range on Protein: 78-223
Range on HMM: 17-167/174.0
GGLYLGGFRGViNTQFLREANVTHIVNTAKGLEIF---GPKYLTAVQEARDILKINFLELNWEDTETWLIPDsdIRTLCNYIQTGLDM-QGQSVFVHCAQ
..|..|..    . ..|.| ..|..|.  .  |      . |    .|    | |..| |.|.| ..  ..   .......... |   .|  | |||  
prliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpvlVHCsa

GKSRSSTAVVAYVMVAKGL-SLKESLGLVQSLH---KMAEPNPHFMKRLEEFEK
|..|. | |.|| |   .| || . | ||..|.    .. ..|.... | .|||
GvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
PTEN_1 78-226 2e-18 61.9 In-house 46-192 (196) alignment 
Range on Protein: 78-226
Range on HMM: 46-192/196.0
GGLYLGGFRGVI-NTQFLREANVTHIVNTAKGLEIfgP--KYLTAVQEArdiLKINFLELNWEDTETwlIPDSDIRTLCNYIQTGLD--MQGQSVFVHCA
.|||.|  . |  . . | | ..|..|| . . |.  .   |     ..    ....|.. .||  .   . | .   |. .   |    .|  | |||.
eglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffk...sgveylhfpieDhga..pslselfdicksfiewllsdpngnvVlVHCk

QGKSRSSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSEL
.|..|| | | || | ...|. .| | ||..    . ||. ...||.|.... |
aGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0045098 (Phosphotyrosine protein) phosphatases II 89-225 6.4e-17 57.3 In-house 79-271 (278) alignment 
Range on Protein: 89-225
Range on HMM: 79-271/278.0
INTQFLREANVTHIVNTAKGLEIFGPKY-------------------------------------LTAVQEARDILKINFLEL-NWEDTETWLIP-DSDI
 . ..|.| ..|.||. .. .|    |.                                     ||  .|    .... | . .|.| ..   |  . .
dfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksf

RTLCNYIQTGLDM-------------QGQSVFVHCAQGKSRSSTAVVAYVMVAK---GLSLKESLGLVQSLHKM-AEPNPHFMKRLEEFEKSE
  |...|.  |.              .|  |.|||  |..|. | |.|| |      |..| | .  ..|   . | .|..... |.||.   
lellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_MKPLT_pd Subfamily MKPLT 80-223 6.6e-17 55.5 In-house 29-158 (164) alignment 
Range on Protein: 80-223
Range on HMM: 29-158/164.0
LYLGGFRGVINTQFLREANVTHIVNTAKGLEifgpkylTAVQEArdilkINFLELNWEDTETWLIPdSDIRTLCNYIQTGLDMqGQSVFVHCAQGKSRSS
||||    . | . |.. ..||||| ...          |  ..     ...|... ||. .  .  | .  . ...   .|  |  |.||| |||||||
lylGnakhatnekvlkdlkithivnvsqekk.......dafpks.....veYlqvkvedesdeqls.sfleraakfladaids.GGrvlvhcvqGksrss

TAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
.. ||...  ||  |||.   ..    .. ||  |.|.| .||.
svtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 80-223 6.6e-17 55.5 In-house 29-158 (164) alignment 
Range on Protein: 80-223
Range on HMM: 29-158/164.0
LYLGGFRGVINTQFLREANVTHIVNTAKGLEifgpkylTAVQEArdilkINFLELNWEDTETWLIPdSDIRTLCNYIQTGLDMqGQSVFVHCAQGKSRSS
||||    . | . |.. ..||||| ...          |  ..     ...|... ||. .  .  | .  . ...   .|  |  |.||| |||||||
lylGnakhatnekvlkdlkithivnvsqekk.......dafpks.....veYlqvkvedesdeqls.sfleraakfladaids.GGrvlvhcvqGksrss

TAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
.. ||...  ||  |||.   ..    .. ||  |.|.| .||.
svtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_DSP6_pd Subfamily DSP6 79-224 8.9e-17 55.0 In-house 20-153 (158) alignment 
Range on Protein: 79-224
Range on HMM: 20-153/158.0
GLYLGGFRGVINTQFLREANVTHIVNTAKGLeifgPKYLTAVQEArDILKINFlELNWEDTETWLIPDSdirtlCNYIQTGLDmQGQSVFVHCAQGKSRS
 ||||  .   |.. |.. .. ...| .. |    |.     .|    |.|   | ...   . ..|..      ..|. .   . ..|.|||  | |||
llylGsakdasnlevlkklkikyvlnvtsnl....pnkfeesgel.kylqipi.edhlsqnlakffPea.....iefidears.kkskvlvhClaGisrs

STAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKS
 | ..||.|  . |||...  ||.. .    || .||..| .||.|
vtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
subfamily_DSP10_pd Subfamily DSP10 80-224 9.6e-17 55.3 In-house 21-152 (159) alignment 
Range on Protein: 80-224
Range on HMM: 21-152/159.0
LYLGGFRGVINTQFLREANVTHIVNTAKGLeifgPKYLTAvqeardiLKINFLELNWEDTETWLIPdSDIRTLCNYIQTgLDMQGQSVFVHCAQGKSRSS
|.||  ..  ... |.. |.|...| .. .    |.. .         ....  .. .||..  .         ..|.     .|..|.|||  | |||.
LflGsekdaadldaldrlnitavlnvttsv....Pnefee.......ealkYkripvsDtskqnlk.qyfeealefiee.arkkgsrvLvhCqaGisrsa

TAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKS
| |.||.|  ..|||...  .|..   .  ||  || .| ||||.
tvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
0051082 (Phosphotyrosine protein) phosphatases II 77-220 1.5e-16 55.8 In-house 12-148 (151) alignment 
Range on Protein: 77-220
Range on HMM: 12-148/151.0
GGGLYLGGFRGVINTQFLREANVTHIVNTAKGLEIFgpkYLTAVQEARDILKINFLELNWEDTEtwlIPDSdIRTLCNYIQTGLDMQGQSVFVHCAQGKS
.||||..|.    . ..|.| ....|||  .  |.    |..   .. .|  ...  |.| |.    .|.| . .. ....  ||.... |.|||  ||.
tgglyrsggpladflellkelgiktivnlrseeerg...ycpeylpelgievlhipildwpdpg...lpls.fdavleflellldkkngpvlvHCsaGkg

RSSTAVVAYVMVaKGLSLKESLGLVQSLHK-MAEPNPHFMKRLEE
|. | |..| |   |.|| | |  ... .  .  || .|.. | .
RTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Slingshot_pd Subfamily Slingshot 80-222 2.7e-16 53.4 In-house 26-154 (169) alignment 
Range on Protein: 80-222
Range on HMM: 26-154/169.0
LYLGGFRGVINTQFLREANVTHIVNTAKGLEIFGPKYLTAVQeardilkINFlelnWEDTETWLIPDSDirTLCNYIQTGlDMQGQSVFVHCAQGKSRSS
.|||      | . |.| .|..|.| .| .. | |. .. ..       |.     ... || |..  .  .  ..|..    .| .|.|||  | |||.
vylGsewnasnleelkengveyilnvtkeidnffpekfeyln.......irv....ydeeetdllkywn..etykfieka.kkkgskvlvhckmGvsrsa

TAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFE
..|.|| | . ||||.|.|  |..  ....||. |.|.|||.|
stviayamkeyglsleealeyvkerrsvikPnkgflkqleeye
0040439 (Phosphotyrosine protein) phosphatases II 91-223 1.8e-14 49.5 In-house 71-243 (249) alignment 
Range on Protein: 91-223
Range on HMM: 71-243/249.0
TQFLREANVTHIVNTAKGLEIFGPKYL----------------------------------TAVQEARDILKINFLELNWEDTETWLIpDSDIRTLCNYI
 ..|.| ..|.||.  .  |    |.                                   | ...  ..    .  ..| |. .     .|.  .....
wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvpps.fedlldfieav

QTGLDM--QGQSVFVHCAQGKSRSSTAVVAYVM-----VAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
.. |.   .|  |.|||  |..|. | ..|| |       .|..|.| . |..|   .| .||.... | |...
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0042113 (Phosphotyrosine protein) phosphatases II 78-223 1.9e-14 49.1 In-house 52-240 (245) alignment 
Range on Protein: 78-223
Range on HMM: 52-240/245.0
GGLYLGGFRGVINTQ----FLREANVTHIVNTAKGLEIFGPK----------------------------------YLTAVQEARDILKINFLELNWEDT
........    ...    .|.| ..|.||.  .  |   .|                                   .| ...      |... |.|.| 
pkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdh

ETWLIPDsDIRTLCNYIQTGLD-MQGQSVFVHCAQGKSRSSTAVVAYVM-----VAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
 .  ... ..  ....... |   ..  |.|||  |..|. | ..|| |       .|.|| | .  ..|   .| ..|.... | |...
gvpdlle.llldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 79-223 1.9e-14 49.3 In-house 45-239 (243) alignment 
Range on Protein: 79-223
Range on HMM: 45-239/243.0
GLYLGGF--------RGVINTQFLREANVTHIVNTAKGLEIFGPKYLTA--------------------------------VQ-EARDILKINFLELNWE
.|.....        .   . ..| | ..|.||.  .  |    |.                                   .. .    | |... |.| 
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

DTETWLIpDSDIRTLCNYIQTG--------LDMQGQSVFVHCAQGKSRSSTAVVAYVMVAK-GLSLKESLGLVQSLHKM-AEPNPHFMKRLEEFEK
|  .     .|.  .......          . .|  | |||  |..|. | ..||.|  . |..| | . |...   . | ..|.... | |...
dhgvPds.pedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall
0051429 (Phosphotyrosine protein) phosphatases II 80-224 2.3e-14 49.2 In-house 24-223 (272) alignment 
Range on Protein: 80-224
Range on HMM: 24-223/272.0
LYLGGFR---GVINTQFLREANVTHIVNTAKGLEIFGPKYLTAVqeardiLKINFLELNWEDTETWLIP-------------------------------
||..|.     . . ..|.| ....||.  .  |.   |.            |..| |...|...  |                                
lyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw......pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

-------------------DSDIRTLCNYIQTgldmqGQSVFVHCAQGKSRSSTAVVAYVMVaKGLS--------------LKESLGLVQSLHKMAEPNP
                   .. ...| .....     |. | |||. ||.|. |.|... ..  |.|              | | .  ...    | ...
earevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqte

HFMKRLEEFEKS
.... | |... 
eqylflyealle
subfamily_STYXL1_pd Subfamily STYXL1 79-225 4.4e-14 46.0 In-house 18-153 (157) alignment 
Range on Protein: 79-225
Range on HMM: 18-153/157.0
GLYLGGFRGVINTQFLREANVTHIVNTAKGLEIfgpkYLTAVQEARDILKINFlelnwEDTE-TWLIpdSDIRTLCNYIQTGLDmQGQSVFVHCAQGKSR
 |||| ..   | .  ..  |   || ..  .      ...|... ..|.|.      ||.. . |.  . .. ....|..    .|. |.|   .| ||
klylGnykqaqnpaikkdlkvkahvnvsmdadk....liagvadvakllhiav.....edeneadll..erlkeavqfiekhkk.egevvlvfsnkGisr

SSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSE
| ....||.|  | ..||...  ..  ..  .||  |...|.|.||. 
saaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 80-223 4.8e-14 45.7 In-house 6-139 (145) alignment 
Range on Protein: 80-223
Range on HMM: 6-139/145.0
LYLGGFRGVINTQFLREANVTHIVNTAKGLEIfgpkyltAVQEARDiLKINFLELNWEDTETWLIPDsDIRTLCNYIQTGLDmQGQSVFVHCAQGKSRSS
|| |      ..  |.|  .. ||| | |  .       | ||..   .|. | .  || |.. . .  .  . ..|. | . .|  |||||  | ||| 
lyvgsalhandvptlqelgisrivnmaagslv.......asqelks.esieillitaedlesydlsq.hfdevtdfidkgke.egagvfvhcmagvsrsv

TAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
|  ||..|   ...| |.   |.|   .| || .|.| | ..||
tvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlek
subfamily_PTPMT1_pd Subfamily PTPMT1 89-224 5.8e-14 46.9 In-house 38-167 (171) alignment 
Range on Protein: 89-224
Range on HMM: 38-167/171.0
InTQFLREANVTHIVNTAKGLEIfgpKYLTAVQEARDILKINFLELNWEDTETwLIPDSDIRTLCNYIQTGlDMQGQSVFVHCAQGKSRSSTAVVAYVMV
| .. ... ||  .|.. .  |.   | |.  .|    | ...|.|.  |         ..    ..|.     .|..|.|||  |..||.| | .|.| 
i.keLiekenvkavvslneeyel...kalansteewkklgveqlqlatvDfte.apdleklekgvefiekv.askgkrvYvHCkaGrgRsatlvacylmk

AKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKS
 . ||..| |  ...  |. . . . .| |.|.|..
keklspeeAlkalkkkRkiirlakkqwkalqeyeek
subfamily_DSP8_pd Subfamily DSP8 79-224 1.3e-13 44.8 In-house 21-153 (159) alignment 
Range on Protein: 79-224
Range on HMM: 21-153/159.0
GLYLGGFRGVINTQFLREANVTHIVNTAKGLeifgPKyLTAVQEARdILKINFLELNWEDTETWLipdsdiRTLCNYIQTGLDMQGqSVFVHCAQGKSRS
 ||||  . |.. ..|.. ......|. .      || |  ..|.. .|..   . . |.   |.       . ...|.     .| .|.||.  |.|||
nlylGsqkdvlseellsklgisyvlnasnsc....pk.leelkesk.flrvPvkDkydekllpwf......dksvefidkakseng.rvlvhvlaGisrs

STAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKS
.| ..||.|    .|| |.   |..  .. .||  |...| |.||.
atvaiayimktlemsldeayrfvkekrptispnlnflgqLleyeke
0045450 (Phosphotyrosine protein) phosphatases II 92-223 1.8e-13 46.4 In-house 125-301 (307) alignment 
Range on Protein: 92-223
Range on HMM: 125-301/307.0
QFLREANVTHIVNTAKGLEI-----------------FGPKYLTAVQEARdILKINFLELNWEDT------------------ETWLIPD-SDIRTLCNY
..|.| .||.||.  .  |                  .|.   | . |     ..  . |. .|.                  .. . |. ...  ....
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

IQT--GLDMQGQSVFVHCAQGKSRSSTAVVAYVMVAKG--------LSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
...  . . .|  | |||  |..|. | ..||.|   .        ..| | . |...    | .||.... | |...
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0038934 (Phosphotyrosine protein) phosphatases II 145-223 3.6e-13 45.1 In-house 95-174 (194) alignment 
Range on Protein: 145-223
Range on HMM: 95-174/194.0
PDSDIRTLCNYIQTGLDM-QGQSVFVHCAQGKSRSSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEK
... ... .. ... |.  .|. | |||  |..|. | |.|| .   |.|..|...|...  . | ||..... | .. |
sleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryk
0039614 (Phosphotyrosine protein) phosphatases II 92-224 1.9e-12 42.8 In-house 119-287 (297) alignment 
Range on Protein: 92-224
Range on HMM: 119-287/297.0
QFLREANVTHIVNTAKGLEIF--GPKYLTAVQEARDILKINFL----------------------------ELNWEDTETWLiPDSDIRTLCNYIQTGLD
....| .||.||.  |  |     ..|    ..  . .....|                             ..| |  .     ...  ....... | 
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvpp.slellleflelvreala

M--QGQSVFVHCAQGKSRSSTAVVAYVM-----VAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKS
   .|  | |||  |..|. | ..|| |       .|....| .  ...   .| ..|.... | .... 
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
subfamily_MSG5_pd Subfamily MSG5 128-222 4.5e-12 39.4 In-house 67-157 (165) alignment 
Range on Protein: 128-222
Range on HMM: 67-157/165.0
KINFLELNWEDTETWLipdSDIRTLCNYIQTGlDMQGQSVFVHCAQGKSRSSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFE
 ...  ..|| .        |. .| . | .    ... ..|||  | |||.. .|||.|   .|||...  ...|  .  .|.  .. .| |.|
avkyyhiewehdskiv...kdlsrltriihaa.tskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewe
0043336 (Phosphotyrosine protein) phosphatases II 92-221 1.6e-11 39.7 In-house 106-272 (278) alignment 
Range on Protein: 92-221
Range on HMM: 106-272/278.0
QFLREANVTHIVNTAKGLEIFGPK-----------------Y----------------LTAVQEARDILKINFLELNWEDTETWLiPDSDIRTLCNYIQT
....| .||.||.  .  |   .|                 .                .|  ..        .  |.| | ..   . |..  .......
rmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavre

GLDMQGQSVFVHCAQGKSRSSTAVVAYVM-----VAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEF
 |. ..  | |||  |..|. | ...|..       .|..| | .  ...   .| ..| ... | |.
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
0036941 (Phosphotyrosine protein) phosphatases II 93-222 3.5e-11 38.4 In-house 97-273 (297) alignment 
Range on Protein: 93-222
Range on HMM: 97-273/297.0
FLREANVTHIVNTAKGLEIFGPKYLTAVQEA-RDILKINFLELNWEDTETWLI-----------------------------PDSD----IR---TLCNY
 . | |||.||.  .  |   .|.     .  .. |. . . ..  ..|..|                              || .    ..    ....
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfiel

IQT--GLDMQGQSVFVHCAQGKSRSSTAVVAYVM--------VAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFE
...   | ..|  | |||  |..|| | ..|..|          .|....| .  . .   .| ... ... | |..
vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal
subfamily_STYX_pd Subfamily STYX 79-225 3.9e-11 36.3 In-house 18-157 (166) alignment 
Range on Protein: 79-225
Range on HMM: 18-157/166.0
GLYLGGFRGVINT--QFLREANVTHIVNTAKGLEIfgpKYLTAvqEARDilKINFLELNWEDTETWLIPdSDIRTLCNYIQTGLDMQGQsVFVHCAQGKS
||.|| .   ...  . |..  .||||   . .|    ...    . .|  .. .| |.  |. .  |    . |  ..|.. |.. |. |.||   | |
glflgpysaamksklevlkkhgithivcirqniea...nlikp..nfpd..rfrylvldvadntvenii.rylptvkefiddslqkggk.vlvhgnagis

RSSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFEKSE
||.. |.||.| . ||  .|.   ||      .||  |...|.|.|   
rsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiy
0040438 (Phosphotyrosine protein) phosphatases II 92-222 4.2e-11 38.1 In-house 104-272 (317) alignment 
Range on Protein: 92-222
Range on HMM: 104-272/317.0
QFLREANVTHIVNTAKGLEI----------------FGPKYLTAVQEARdILKINFLELNWEDT----------------ETWLIP--DSDIRTLCNYIQ
... | .||.||.  .  |                 .|.   | ..|      |. ..|  ||.                    .|   ...  ......
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

TGLDMQGQSVFVHCAQGKSRSSTAVVAYVM-----VAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEFE
. |. .|  | |||  |..|. | ..||.|       .|....| .  ...   .| ..| ... | ...
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydal
PTPc_DSPc_SM00012 134-221 3.9e-08 28.8 In-house 8-96 (105) alignment 
Range on Protein: 134-221
Range on HMM: 8-96/105.0
LNWEDTetwLIPD--SDIRTLCNYIQTGLDMQG--QSVFVHCAQGKSRSSTAVVAYVMVAKGLSLKESLGLVQSLHKMAEPNPHFMKRLEEF
..| |.    .|.  ..| .|......    ..  ..| |||  | .|. | |...... .  . .... . | .... .  |. ....|..
tgwpdh...gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy
0047943 (Phosphotyrosine protein) phosphatases II 94-216 4.1e-08 28.5 In-house 97-262 (273) alignment 
Range on Protein: 94-216
Range on HMM: 97-262/273.0
LREANVTHIVNTAKGLEI--------FGPK-------------YLTAVQEARDILKINFLE----------------LNWEDTETWLIPdSDIRTLCNYI
. | ||..||   .  |         . ..             .|. ...  |. . ..                  ..| |  .   . ... ......
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppsl.esllefielv

QTGLDM--QGQSVFVHCAQGKSRSSTAVVAYVM-----VAKGLSLKESLGLVQSLHKMAEPNPHFMK
.. |    ..  | |||  |..|. | ......       .|....| . |..|   .. ..| ...
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr
0051299 (Phosphotyrosine protein) phosphatases II 128-207 5.7e-07 24.8 In-house 184-267 (288) alignment 
Range on Protein: 128-207
Range on HMM: 184-267/288.0
KINFLELNWEDTETWLiPDSDIRTLCNYIQTGLDMQGQSVFVHCAQGKSRSSTAVVAYVM-----VAKGLSLKESLGLVQSLHKM
 . |  .|| |  .     ... ........ |  .|  | |||  |..|. | ......       .|... | .  . .   .
vthfhytnwpdhgvpd.spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpg
0050432 (Phosphotyrosine protein) phosphatases II 96-197 3.1e-06 22.2 In-house 130-270 (308) alignment 
Range on Protein: 96-197
Range on HMM: 130-270/308.0
EANVTHIVNTAKGLEIF---GPKYLTAVQ----------------------------------EARDILKINFLELNWEDTETWLIPdSDIRTLCNYIQT
| ||..||   |  |      ..|    .                                  .   .    |  .||.|  .   | ... ........
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpsp.eilldflelvrk

GLdmQGQSVFVHCAQGKSRSSTAVVAYVM-----VAKGLSLKES
 |  .|  . |||  | .|. | ......       .|... | 
sl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfea
0046845 (Phosphotyrosine protein) phosphatases II 131-203 3.8e-06 22.0 In-house 170-251 (284) alignment 
Range on Protein: 131-203
Range on HMM: 170-251/284.0
FLELNWEDTETWLIpDSDIRTLCNYIQTGLD--MQGQSVFVHCAQGKSRSSTAVVAYVMVAK--------GLSLKESLGLVQS
|  ..| |  .     .|. ........ |.   .|  . |||  |..|. | ......           |... | .  . .
fhytswpdhgvpps.pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlre