Gene DSP11 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP11
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP006_AA protein Get Run
AqueP006_AA_12-192 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP11_pd Subfamily DSP11 4-191 2.7e-81 265.7 In-house 1-176 (178) alignment 
Range on Protein: 4-191
Range on HMM: 1-176/178.0
VPDRWLDYTPLKDHIEGTRIIAIKTPLKEFFntgltseemakrriDTGVPVEKEFTSTQLVRMLQSKNLNLGLVIDLTNTDRYYSWKSFEDLGIEHYKLR
||||| .|.|..|.|||||.||.||||||.|              |..|..||.||...|...||.|| .||||||||||||||..|...| |....||.
vPdrwkkykpvgdkiegtrfiafktPlkesf..............dkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylkln

CPGHEIPSEEIYKSFSERLSRFL--SKESNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDAIKKFGDARGHSMERENYLKDLRKLVNE
|||||.|.||..|.|.|....||  .|.......||||||||||||||||||....|.|.||||..| .|||||.|||||||||.||...
cpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkklekd
0038934 (Phosphotyrosine protein) phosphatases II 3-192 3e-50 165.9 In-house 1-176 (194) alignment 
Range on Protein: 3-192
Range on HMM: 1-176/194.0
KVPDRWLDYTPLKDHIEGtRIIAIKTPLKEffntgltseemakrRIDTGVPVEKEFTSTQLVRMLQSKNLNLGLVIDLTNTDRYYSWKSFEDLGIEHYKL
|.|||||.|... |.|.| |.||.|.||..              ..|. .. .. |. . |||.|...| .||||||||||.|||. . ||..|||..||
klPdrwlkyervgdiitg.rfiafkvPlsg..............sldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylkl

RCPGH-EIPSEEIYKSFSERLSRFLSKESNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDAIKKFGDARGHSMERENYLKDLRKLVNEG
 .|.. ..|| ||...| . . .||.. ....|||||..|..|||.|...||....|.  |.||. | ..|...... .||..|.| ..| 
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
subfamily_RNGTT_pd Subfamily RNGTT 5-192 8.6e-41 133.7 In-house 1-174 (189) alignment 
Range on Protein: 5-192
Range on HMM: 1-174/189.0
PDRWLDyTPLKDHIEGTRIIAIKTPLKeffntgltseemakRRIDTGVPVEKEFTSTQLVRMLQSKNLNLGLVIDLTNTDRYYSWKSFEDLGIEHYKLRC
|.|||.  | | ..   . ...||||               .| |  .. |..|. . |. .|.... .||||||||||.|||  . .|. ||.. ||.|
PerWln.CPrkgkliaekflpfktpls..............krydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqc

PGHEI-PSEEIYKSFSERLSRFLSKESNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDAIKKFGDARGHSMERENYLKDLRKLVNEG
 |.   |..|  |.| . ...| .|...| ..|||||| ||||.||. ||||.  .. |.|.. |  ||   . .|.|||.| .  .. 
agkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadv
0036282 (Phosphotyrosine protein) phosphatases II 6-187 1.1e-28 95.5 In-house 2-164 (174) alignment 
Range on Protein: 6-187
Range on HMM: 2-164/174.0
DRWLDYTPLKDHIEGTRIIAIKTPLKeffntgltseemakrridtGVPVEKEFTSTQLVRMLQSKNLNLGLVIDLTNTDRYYswksFEDLGIEHYKLRCP
.......||. ..  .|.|| . ||.                    ..  ||. .| .|..|..| |.|...|......|..    .|.|||....| .|
sdyinaspldlsyitprliagqgpla...................fwemlkelgittvvmlleekelglykcinywpelred....lerlgiqylylpwp

GHEIPSEEIYKSFSERLSRFLSKESNEYVAVHCTHGVNRTGYLICRYLVEHCGF-ETEDAIKKFGDAR---GHSMERENYLKDLRK
.|. |. .|  .| ... ..||. ..  |.|||..||.|||.|.. ||......  ..||.. .  .|   ... ....... |..
DhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyy
0043147 (Phosphotyrosine protein) phosphatases II 51-186 1.3e-24 82.3 In-house 26-154 (172) alignment 
Range on Protein: 51-186
Range on HMM: 26-154/172.0
GVPveKEFTSTQLVRMLQSKNLNLglVIDLTntDRYYSWKSFEDLGIEHYKLRCPGHEIPSEEIYKSFSERLSRFLSKESNEYVAVHCTHGVNRTGYLIC
  |    .|  . .|||.... ..  ...||  ...| .. .|.|||... | .| |  |. |.  .| | . ..| ..... |.|||..||.|||.|..
qgp..lrntladfwrmlkelgith..ivnlt..ellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlva

RYLVEhCGFETEDAIKKFGDARGHSMERENYLKDLR
 ||.. .|.  |.|.. . ..|... . ..... |.
aylml.lglsleeavalvrekRpgavqnpsqyrfly
0044763 (Phosphotyrosine protein) phosphatases II 70-189 3.2e-24 81.0 In-house 45-167 (178) alignment 
Range on Protein: 70-189
Range on HMM: 45-167/178.0
KNLNLGLVIDLTNTDRYY----SWKSFEDLGIEHYKLRCPGHEIPS-EEIYKSFSERLSRFLSkESNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDA
|.|.......||......      . .|. ||..... .|.|  |.  |.   | | . ..|. |... |.|||..||.|.|.|.. ||. ..|.  |.|
kelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkklglsleea

IKKFGDARGhSMERENYLKDLRKLV
|. .  .|   ......|. |... 
ielvrerRp.ivpnpgqlrqLyefe
0041856 (Phosphotyrosine protein) phosphatases II 61-184 5.3e-24 80.2 In-house 48-162 (182) alignment 
Range on Protein: 61-184
Range on HMM: 48-162/182.0
TQLVRMLQSKnlNLGLVIDLTntDRYYSWKSFEDLGIEHYKLRCPGHEIPSeeiYKSFSERLSRFLSkeSNEYVAVHCTHGVNRTGYLICRYLVEHCGFE
 . .|||..   . .....||  ...|  . .|.|||....| .|.|..|.     .. . . . |.  ... |.|||..||.|||.|.. ||....|. 
adflrmlkel..gittivnlt..eelywpellerlgiqylylpwpDhgvpd...ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkklgvs

TEDAIKKFGDARGHSMERENYLKD
 |.|.| .  .| .. ...|..  
leeavklvrsrRpgmvitpnqyff
0048179 (Phosphotyrosine protein) phosphatases II 65-187 8e-23 76.2 In-house 21-139 (144) alignment 
Range on Protein: 65-187
Range on HMM: 21-139/144.0
RMLQSKNLNLGLVIDLTNTdryYSWKSFEDLGIEHYKLRCPGHEIPSE-EIYKSFSERLSRFLSkeSNEYVAVHCTHGVNRTGYLICRYLVEHCGFETED
.. . |.|....||.||..   | . ..|. ||....| .|.|..|.  |.  .| | . ..|.  ... |.|||..||.|||.|.. ||. ..|.  |.
dlellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglslee

AIKKFGDARGHSMERENYLKDLRK
|.. .  .| .. . ...|. |..
alalvrsrrpgavpnpgqlrfLle
0040438 (Phosphotyrosine protein) phosphatases II 45-192 9.6e-23 76.4 In-house 86-275 (317) alignment 
Range on Protein: 45-192
Range on HMM: 86-275/317.0
KRRIDTGVPVEKefTSTQLVRMLQSKnlNLGLVIDLTNTDRY--------YS--------------WKSFEDLGIEHYKLRC------------------
.. | |..| ..  |     ||..    ...... ||... .        ..              .. .|. ||....|..                  
rkfIatqgPlpn..tvedFwrmvweq..gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytg

-PGHEIP-SEEIYKSFSERLSRFLSkESNEYVAVHCTHGVNRTGYLICRYLV-----EHCGFETEDAIKKFGDARGHSMERENYLKDLRKLVNEG
 | | .| | ..  .| |.. ..|. .... |.|||..||.|||..|. ||.     ...|.  |.|.|..  .|..... ..... | ....| 
Wpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
0049260 (Phosphotyrosine protein) phosphatases II 73-186 1.4e-22 75.5 In-house 31-143 (152) alignment 
Range on Protein: 73-186
Range on HMM: 31-143/152.0
NLGLVIDLTNTDRYYSWKSFEDLGIEHYKLRCPGHEIPSEEIYKSFSERLSRFLSKESNEYVAVHCTHGVNRTGYLICRYLVEhCGFETEDAIKKFGDAR
.||  . .. |.... .| ... .|... | .| |  |. ...  |  .. ..| ..... |.|||..||.||| |.. ||.. .|.. |.|.. .  .|
elgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekR

GHSMERENYLKDLR
 .. . ...|. | 
pgavpnpgqlrfly
0040439 (Phosphotyrosine protein) phosphatases II 22-189 1.8e-22 75.6 In-house 55-242 (249) alignment 
Range on Protein: 22-189
Range on HMM: 55-242/249.0
RIIAIKTPLKEffntgltseemakrridtgvpvekefTSTQLVRMLQSKNlnLGLVIDLTNTDRY-----------------------------------
|.|| ..||.|                          |     |||.  .   . ...||.....                                   
rfiatqgPlpe..........................tvedfwrmlwelg..itvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytv

--------YSWKSFEDLGIEHYKLRcpGHEIP-SEEIYKSFSERLSRFLSKE-SNEYVAVHCTHGVNRTGYLICRYLV-----EHCGFETEDAIKKFGDA
        |  .|.. |.| ....    | .| | |.  .| |..  .|..  ... |.|||..||.|||..|. ||.     ...|.  |.|.|.. ..
rtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsq

RGHSMERENYLKDLRKLV
|... . ..... | ...
Rpgavqnpeqyrflyeal
0046846 (Phosphotyrosine protein) phosphatases II 62-188 4.9e-22 74.0 In-house 38-168 (176) alignment 
Range on Protein: 62-188
Range on HMM: 38-168/176.0
QLVRMLQSKnlNLGLVIDLTNTD------RYYSWKSFEDLGIEHYKLRCPGHEIPSEEIYKSFSERLSRFLSKEsnEYVAVHCTHGVNRTGYLICRYLVE
. ..||..   . ..|..||.         .. |. .|.|||... |  | | .|. |.  .. | . ..|..   . |.||| .|..||| |.. ||.|
dflemlkel..gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGigRtgtlvaaylle

H-CGFETEDAIKKFGDARG-HSMERENYLKDLRKL
. .|.  |.|.... . |  .. . ..... |.. 
lekglsveealalvreqRplgavqtpeQyrflyef
0048076 (Phosphotyrosine protein) phosphatases II 65-188 5.7e-22 73.4 In-house 21-138 (145) alignment 
Range on Protein: 65-188
Range on HMM: 21-138/145.0
RMLQSKNLNLGLVIDLTNTDRYYSwksfeDLGIEHYKLRCPGHEIPSE-EIYKSFSERLSRFLSKesNEYVAVHCTHGVNRTGYLICRYLVEHCGFETED
.. . |.|....|..||.. ....     .|||... | .|.|..|.  |.  .| | . ..|..  .. |.|||..||.|||.|.. ||. ..|.  |.
dlellkdlgittvlnltselelle.....rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmlllgvslee

AIKKFGDARGHSMERENYLKDLRKL
|....  .| .. .....|. |...
alelvrsqrpgavpnpgqlrflyef
0037934 (Phosphotyrosine protein) phosphatases II 46-189 5.8e-22 73.9 In-house 45-238 (243) alignment 
Range on Protein: 46-189
Range on HMM: 45-238/243.0
RRIDTGVPVEKefTSTQ----LVRMLQSKnlNLGLVIDLTNTD----------------------------------------RYYSWKSFEDLGIEHYK
| | |..| ..  |  .     .|||..   . . ...||...                                        ...... .. |.| .. 
rliatqgPlpe..tveddlasfwrmlwel..gitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

LRCPGHEIPS-EEIYKSFSERLSRFLSK-------ESNEYVAVHCTHGVNRTGYLICRYLVEHC-GFETEDAIKKFGDARGH-SMERENYLKDLRKLV
|  |.| .|.  |.  .| . .  |...        |.. |.|||..||.|||.||. ||. .. |.  |.|.|.. . |.. . . ..... |....
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 50-189 7.5e-22 73.4 In-house 57-239 (245) alignment 
Range on Protein: 50-189
Range on HMM: 57-239/245.0
TGVPVEKefTSTQLVRMLQSknLNLGLVIDLTNTDRYYS-----------------------------------------WKSFEDLGIEHYKLRCPGHE
|. | ..  |     |||..  |..  ...||... .                                            ....  .| .. | .|.| 
tqgPlpe..tvedfwrmlwe..lgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhg

IPS-EEIYKSFSERLSRFLSKESNEYVAVHCTHGVNRTGYLICRYLV-----EHCGFETEDAIKKFGDARGHSMERENYLKDLRKLV
.|.  |.  .| |.. ..|.. ||. |.|||..||.|||..|. ||.     ...|.  |.|.|.. . |... . ..... |....
vpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0049772 (Phosphotyrosine protein) phosphatases II 62-189 7.6e-21 70.6 In-house 167-270 (314) alignment 
Range on Protein: 62-189
Range on HMM: 167-270/314.0
QlvrmlqsknlnlglvidltntDRYYSWKSFEDLGIEHYKLRCPGHEIPSEEIYKSFSERLSRFlskESNEYVAVHCTHGVNRTG-YLICRYLVEHCGFE
.                     ...|. . ||.|||... . .|... |..|....| | . ..   . .. |.|||..|..||| .... ||. ..|. 
k.....................eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvs

TEDAIKKFGDARGhSMERENYLKDLRKLV
 |.|.. .  .|     ...... |. ..
leealedvrlkRp.inpnpgfieqleqye
0051082 (Phosphotyrosine protein) phosphatases II 62-177 1.2e-20 69.1 In-house 24-137 (151) alignment 
Range on Protein: 62-177
Range on HMM: 24-137/151.0
QLVRMLqsKNLNLGLVIDLTNTD-RYYSWKSFEDLGIEHYKLRCPGHEIPSEEIYKSFSERLSRFLSKESNEYVAVHCTHGVNRTGYLICRYLVEhCGFE
. ...|  |.|..  ...|.... |.|  . ...||||.. . ....  |. ...  .  .. ..| . .|  |.|||..|..||| |.. ||.  .|. 
dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvs

TEDAIKKFGDARGHSME
 |.|.. .   |...  
leealeeyrlkrpgvvq
0045450 (Phosphotyrosine protein) phosphatases II 14-189 1.8e-20 69.3 In-house 100-300 (307) alignment 
Range on Protein: 14-189
Range on HMM: 100-300/307.0
LKDHIEGTRIIAIKTPLKEffntgltseemakrridtgvpvekefTSTQLVRMLQSKnlNLGLVIDLTNTD--------RYYSWK---------------
|. .. ....|| ..||.|                          |     |||. .  . .....||...        .|.. .               
ldgydlkrkfIatqgPlpe..........................tvedFwrmlweq..gvtvivmltelvelgrekcaqywPdegeeltygnftvtlls

-----------------SFEDLGIEHYKLRC---PGHEIP-SEEIYKSFSERLSRFLSKE-SNEYVAVHCTHGVNRTGYLICRYLVEHCG--------FE
                 .... ..... . .   |.| .| | |.  .| |.. ..|..  ... |.|||..||.|||..|. ||. ...        . 
eehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd

TEDAIKKFGDARGHSMERENYLKDLRKLV
 ..|.|.. . |... . ..... |....
lleavkllreqRpgavqnpeqyrflyeal
PTEN_1 65-186 6.3e-20 66.8 In-house 58-185 (196) alignment 
Range on Protein: 65-186
Range on HMM: 58-185/196.0
RMLQS-KNLNLGLVIDLTNTDRY----YSWKSFEDLGIEHYKLRCPGHEIPSEEIYKSFSERLSRFLSKES-NEYVAVHCTHGVNRTGYLICRYLVEHCG
..|.. |  .. ||..|.. . .    |. ..|.. |.|....  . |  || .    . ...   |.. . .. |.|||..|..|.| ... ||... .
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk

FETEDAIKKFGDARGHSMERENYLKDLR
.  ..|.. . ..| . . .  ... |.
ltadeAlelvrekRppgapnspsqerll
0045098 (Phosphotyrosine protein) phosphatases II 63-186 5e-19 64.2 In-house 122-265 (278) alignment 
Range on Protein: 63-186
Range on HMM: 122-265/278.0
LVRMLQSKNLNLGLVIDLTNTDRYYSWKSFEDLGIEHYKL-RCPGHEIPSEEIYKSFSERLSRFLSKE---------------SNEYVAVHCTHGVNRTG
 |..|. ..|.   ...|. |. ..  ...| .|..|...   | |..||..|.||| | | . ..                 |.. |.||| .||.|||
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

YLICRYLVEHC---GFETEDAIKKFGDARGH-SMERENYLKDLR
 |.. ||. ..   |.  ..|.|..   |.. . . .. .. | 
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrfly
0043336 (Phosphotyrosine protein) phosphatases II 59-187 2.3e-18 62.1 In-house 100-271 (278) alignment 
Range on Protein: 59-187
Range on HMM: 100-271/278.0
TSTQ-----------------------------------------LVRMLQSKNLNLGLVIDLTNTDRYYSWKsfeDLGIEHYKLRCPGHEIP-SEEIYK
|                                             |..|  . |.   |..|. |.......     .  .. |  | |..| | ... 
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges...rtvthyhylgwpdhgvpeslslll

SFSERLSRFLSkESNEYVAVHCTHGVNRTGYLICRYLV-----EHCGFETEDAIKKFGDARGHSMERENYLKDLRK
.| ... ..|.  ||. |.|||..||.|||..|. ||.      ..|.  |.|.|..   |..... ..... |..
dflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0039614 (Phosphotyrosine protein) phosphatases II 45-190 2.4e-18 62.1 In-house 101-286 (297) alignment 
Range on Protein: 45-190
Range on HMM: 101-286/297.0
KRRIDTGVPVEKefTSTQLVRMLQSKnlNLGLVIDLTNTDRY--------------------YSWKSFEDLGIEHYKLRC-----------------PGH
.. | |. | ..  |     ||..    .   .. ||... .                    .  | ... |. ...|.                  | |
rkfIatqgPlpe..tvedFwrmvweq..gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdh

EIP-SEEIYKSFSERLSRFLSKE-SNEYVAVHCTHGVNRTGYLICRYLV-----EHCGFETEDAIKKFGDARGHSMERENYLKDLRKLVN
 .| | |.  .| | . ..|..  ... |.|||..||.|||..|. ||.     ...|.  ..|.|..  .|... . ..... |.... 
gvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
DSPc Dual specificity phosphatase, catalytic domain 68-187 2.9e-17 57.8 Pfam-A 13-129 (133) alignment 
Range on Protein: 68-187
Range on HMM: 13-129/133.0
QSKNLNLGLVIDLTNTDRYYswksFEDLGIEHYKLRCPGHEIPSEEIYKSFSErLSRFLS--KESNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDAI
. ..|.. |||..|.. .      ...   |  .||.| ..  ...| | ..| ...|..  ..... |.|||..|..|...||..|| .  ......|.
lleklgitlvinvtkevpnn....naikkseieylripvedetetkiskelee.avefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAy

KKFGDARGHSMERENYLKDLRK
. . . |.. ......|. |..
efvkerrskispnagflrqLle
DSPc Dual specificity phosphatase, catalytic domain 68-187 2.9e-17 57.8 In-house 13-129 (133) alignment 
Range on Protein: 68-187
Range on HMM: 13-129/133.0
QSKNLNLGLVIDLTNTDRYYswksFEDLGIEHYKLRCPGHEIPSEEIYKSFSErLSRFLS--KESNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDAI
. ..|.. |||..|.. .      ...   |  .||.| ..  ...| | ..| ...|..  ..... |.|||..|..|...||..|| .  ......|.
lleklgitlvinvtkevpnn....naikkseieylripvedetetkiskelee.avefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAy

KKFGDARGHSMERENYLKDLRK
. . . |.. ......|. |..
efvkerrskispnagflrqLle
0051429 (Phosphotyrosine protein) phosphatases II 66-182 4.1e-16 54.9 In-house 41-214 (272) alignment 
Range on Protein: 66-182
Range on HMM: 41-214/272.0
MlqsKNLNLGLVIDLTNTDRYYSWK-SFEDLGIEHYKLRCPGHEIPSEEIY-------------------------------------------------
.   |.|..  ..||.... . . | ...  ||... | ..... |. ...                                                 
l...kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq

---KSFSERLSRflskesNEYVAVHCTHGVNRTGYLICRYLVEhCGFE--------------TEDAIKKFGDARGHSMERENYL
   ... | | .      .. | |||..|..||| ... .|.   |..               |.|...  ..| .. . |  .
eallellellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy
PTPc_motif_SM00404 67-188 1.1e-14 49.5 In-house 21-137 (140) alignment 
Range on Protein: 67-188
Range on HMM: 21-137/140.0
LQSKNLNLGLVIDLTNTDRYYswksfeDLGIEHYKLRCPGHEIPSEEIYKSFSErLSRFLS--KESNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDA
 . |.|.. .||..|.. .        .   .   |..| ..  .... | ... . .|..  ..... | |||..||.|...||. || .  ......|
allkklgithvinvteevslt......kensgfqilqiplddnekdklskyldk.vldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaea

IKKFGDARGHSMERENYLKDLRKL
.. . . | . ....|... | ..
yefvkerRpiispnlnfvrqLiey
subfamily_PTEN_pd Subfamily PTEN 61-175 8.4e-14 47.0 In-house 48-159 (184) alignment 
Range on Protein: 61-175
Range on HMM: 48-159/184.0
TQLVRMLQSKNLNLGLVIDLTnTDRYYSWKSFEDlGIEHYKLRcpGHEIPSEEIYKSFSERLSRFLSKESNEYVAVHCTHGVNRTGYLICRYLVEHCGFE
...|..|..|  .   ...|. ..|.|. |.|..  . .|..    |. |. |. ... | ....|...... |.|||  |  ||| ||. ||.... .|
edvvkflekkhkdhykiynlr.serkydskkfdg.rvavypfd..DhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllksllle

TE-DAIKKFGDARGHS
.. .|.. |  || ..
kaeealelfaeaRtkn
0046845 (Phosphotyrosine protein) phosphatases II 98-184 2.8e-13 45.3 In-house 168-265 (284) alignment 
Range on Protein: 98-184
Range on HMM: 168-265/284.0
EHY-KLRCPGHEIP-SEEIYKSFSERLSRFLSK-ESNEYVAVHCTHGVNRTGYLICRYLVEHC--------GFETEDAIKKFGDARGHSMERENYLKD
 |.  .  | | .| | |.  .| . . ..|.. .... ..||| .||.|||..|. .|. ..        |.  ..|.|.. . | .. . .  .. 
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrf
subfamily_CDC14_pd Subfamily CDC14 70-165 7e-13 43.1 In-house 209-297 (328) alignment 
Range on Protein: 70-165
Range on HMM: 209-297/328.0
KNLNLGLVIDLTNTdrYYSWKSFEDLGIEHYKLRCPGHEIPSEEIYKSFSERLSRFlskesNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDAI
.. |.  |. | .    |  |.|.| |..|. |      .||..| |.| | . .      .  .||||  |. ||| ||  ||..| .| ...||
rknnvttvvrLnkk..lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaeai
0050432 (Phosphotyrosine protein) phosphatases II 77-183 1.6e-12 42.9 In-house 136-289 (308) alignment 
Range on Protein: 77-183
Range on HMM: 136-289/308.0
VIDLTNTDRY------YSWKSFEDLGIEHYKLR--------------------------------------CPGHEIPSE-EIYKSFSERLSRFLskeSN
.. ||... .        | . .. |...|.                                        .| | .|.. ||. .| |.. ..|   ..
IvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pg

EYVAVHCTHGVNRTGYLICRYLV-----EHCGFETEDAIKKFGDARGHSMERENYLK
. ..||| .||.||| .|. .|.     ...|.  ..|.||.   | .. . .....
gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqyl
0047943 (Phosphotyrosine protein) phosphatases II 91-182 1.6e-12 43.0 In-house 133-261 (273) alignment 
Range on Protein: 91-182
Range on HMM: 133-261/273.0
SFEDLGIE-----------------------------HYK-LRCPGHEIP-SEEIYKSFSERLSRFLSKE-SNEYVAVHCTHGVNRTGYLICRYLV----
 .... ..                             |.  .  | | .| | |.  .| | . ..|..  ||. |.||| .||.||| .|. .|.    
tygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldql

-EHCGFETEDAIKKFGDARGHSMERENYL
 .. |.  ..|.|.. . | .. . ....
ekeggvdvleavkllrsqRpgmvqtpeqy
0048567 (Phosphotyrosine protein) phosphatases II 82-176 3.6e-12 40.9 In-house 23-122 (157) alignment 
Range on Protein: 82-176
Range on HMM: 23-122/157.0
NTDRYYSWKSF-EDLGIEHYKLRCPGHeIPSEEIYKSFSERLSRFLS--KESNEYVAVHCTHGV---NRTGYLICRYLVEHCGFETEDAIKKFGDARGHS
 ....|... |  | |. .. .  .    ..  |  .|  .| .||.  .. . ..||||..|     ||..||. ||. |.||  |.||. .  .| .|
lpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgs

M
.
v
subfamily_VSP_pd Subfamily VSP 62-180 4.1e-12 40.5 In-house 63-178 (212) alignment 
Range on Protein: 62-180
Range on HMM: 63-178/212.0
QLVRMLQSKNLNLGLVIDLTnTDRYYSWKSFEDlgiEHYKLRCPGHEIPSEEIYKSFSERLSRFLSKESNEYVAVHCTHGVNRTGYLICRYLVEHCGFET
...|.|. |  .   |..|  ..| |  | |..   .  ...   |..|. |   .|....  .|.|. .. .|.||  | .||| ..| .|..   |||
evarfldtkhrdhykvvnlc.seraydekyfnn...rvkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifet

-EDAIKKFGDARGHSMEREN
 ..... ||. | .  | |.
akesldyfgerrtdktegek
0036941 (Phosphotyrosine protein) phosphatases II 102-191 9.9e-12 40.2 In-house 144-275 (297) alignment 
Range on Protein: 102-191
Range on HMM: 144-275/297.0
L--------------------------------RCPGHEIPS-EEIYKSFSERLSRFLSKE-SNEYVAVHCTHGVNRTGYLICRYLV--------EHCGF
                                   | | .|.  ... .| |.. ..|..  |.. | ||| .||.|.| .|. .|.        ...|.
vevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggv

ETEDAIKKFGDARGHSMERENYLKDLRKLVNE
   .|.||. . | .. . .. .. |. .. |
dileavkklReqRpgavqtleqyrflyealle
0051299 (Phosphotyrosine protein) phosphatases II 89-182 7.3e-11 37.5 In-house 177-275 (288) alignment 
Range on Protein: 89-182
Range on HMM: 177-275/288.0
WKSFEDLGIEHYKLRCPGHEIPS-EEIYKSFSERLSRFLSkESNEYVAVHCTHGVNRTGYLICRYLV-----EHCGFETEDAIKKFGDARGHSMERENYL
.....   . .. .  | | .|.  | . .| ... ..|.  ..  |.||| .||.||| .|. .|.     .. |.. ..|.|..   | .. . .. .
gdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqy
subfamily_PRL_pd Subfamily PRL 84-179 1.7e-09 31.9 In-house 43-137 (151) alignment 
Range on Protein: 84-179
Range on HMM: 43-137/151.0
DRYYSWKSFEDLGIEHYKLRCPGHEIPSEEIYKSFSERLSRFLSKESNEYVAVHCTHGVNRTGYLICRYLVEhCGFETEDAIKKFGDARGHSMERE
.  |. ...|. |||   |       |.||. ... | | .  ..|... |||||  |. |.  |..  |.| .|...|||..   . |  .....
eptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekrrgainsk
subfamily_PTPDC1_pd Subfamily PTPDC1 87-185 1.9e-09 32.2 In-house 73-168 (182) alignment 
Range on Protein: 87-185
Range on HMM: 73-168/182.0
YSWKSFEDLGIEHYKLRCPGHEIPSEEIYKSFSERLSRFLSKEsneYVAVHCTHGVNRTGYLICRYLVEHCGFETEDAIKKFGDARGHSMERENYLKDL
|. ... . || .|..  . .. .| |        ..  |...    |||||  |  ||| ||. ||| .  ...|.|||.  . | .|..  . .. .
YdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelv
PTPc_DSPc_SM00012 103-168 1.9e-08 29.8 In-house 9-82 (105) alignment 
Range on Protein: 103-168
Range on HMM: 9-82/105.0
RCPGHEIPSE-EIYKSFSERLSRFLSKES-NEYVAVHCTHGVNRTGYLICRYLVEHCGFETE------DAIKKF
 .| |..|.| .   .. . . .. .|.. .. | ||| .||.|||.... ... .   ...      . .|..
gwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkel
subfamily_DSP23_pd Subfamily DSP23 100-180 3.2e-08 28.3 In-house 55-136 (148) alignment 
Range on Protein: 100-180
Range on HMM: 55-136/148.0
YKLRCPGHEIPSEEIYKSFSERLSRflSKESNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDAIKKFGDARGHSMER---EN
..|| . .  |. |  . | . .    ..| || |.|||  |  ||| ..  ||| . .. . .|| .    |  |.|    |.
vrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqek
subfamily_DSP12_pd Subfamily DSP12 110-195 1.2e-07 26.2 In-house 60-146 (155) alignment 
Range on Protein: 110-195
Range on HMM: 60-146/155.0
PSEEIYKSFsERLSRFLSK--ESNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDAIKKFGDARGHSMERENYLKDLRKLVNEGDKS
|.|.| . . ..  .|...  | .. | |||. || |   ..  ||. . ... |.|.|.  ... .    |..|. |.   . | | 
peediLshl.deavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckv
subfamily_PTPMT1_pd Subfamily PTPMT1 88-186 1.1e-06 23.2 In-house 65-162 (171) alignment 
Range on Protein: 88-186
Range on HMM: 65-162/171.0
SWKSFEDLGIEHYKLRCPGHE-IPSEEIYKSFSERLSRFLSKESNeyVAVHCTHGVNRTGYLICRYLVEHCGFETEDAIKKFGDARGHSMERENYLKDLR
| .... ||.|...|. . .   |. |  .   | .... || .   | |||  |  |.. |.  ||. .  ...|.|.|   . | .   ... .| |.
steewkklgveqlqlatvDfteapdleklekgvefiekvaskgkr..vYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalq
subfamily_DSP3_pd Subfamily DSP3 92-191 7.1e-06 19.8 In-house 58-156 (162) alignment 
Range on Protein: 92-191
Range on HMM: 58-156/162.0
FEDLGIEHYKLrcPGHEIPSEEIYKSFSeRLSRFLSK---ESNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDAIKKFGDARGhSMERENYLKDLRKL
..||.|... |  . .. |. .. | |. . ..|. .   ...  | |||. || |   |.  ||. .  ..  .||..  . |   .  | .|| |..|
ykdleikylGl..evdDvpefdlskyFe.taakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLael

VNE
 .|
dee
subfamily_Auxilin_pd Subfamily Auxilin 100-169 8.5e-06 18.6 In-house 74-141 (166) alignment 
Range on Protein: 100-169
Range on HMM: 74-141/166.0
YklrCPGHEIPSEEIYKSFSERLSRFLSKESNEYVAVHCTHGVNRTGYLICRYLVEHCGFET-EDAIKKFG
    .| ...|. |   . .  |  .| |.... | |||. |.  .. |.. .||    ... |.|.. | 
g...wparraPnLeslvevcrnlyswlkkdpknvvvvhckDGraasavlvsallvfcrllsepesavrlfs
subfamily_DSP10_pd Subfamily DSP10 100-174 9e-06 19.6 In-house 61-135 (159) alignment 
Range on Protein: 100-174
Range on HMM: 61-135/159.0
YKlRCPGHEIPSEEIYKSFSERLSrFL--SKESNEYVAVHCTHGVNRTGYLICRYLVEHCGFETEDAIKKFGDARGH
|| | | ..  .... . | | |  |.   ..... | |||  |. |   ..  ||..| .   .|| |   ..|  
Yk.ripvsDtskqnlkqyfeeale.fieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpi