Gene DSP12 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP007_AA protein Get Run
AqueP007_AA_1-150 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP12_pd Subfamily DSP12 2-158 6.5e-58 189.5 In-house 3-155 (155) alignment 
Range on Protein: 2-158
Range on HMM: 3-155/155.0
VEILPGLLLGGMSDVQYLlRRKSTVKLTHLLSVVKEALdwsDLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
 .|||||.|||...||.  ......|.||.|||.||.|   . |....| .|.| ||..| |..|.| |..||.|||.|.....|..||||..|.|||.|
srilpglylggleavqee.ellkelkithvlsvikeel...pehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvt

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYKMKGTLNETDKSYKS
|||||..|..|.|...|...||||||.|.||.||..||||..||........|.||.
iviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdtsnkayke
subfamily_DSP19_pd Subfamily DSP19 2-142 9.8e-34 110.9 In-house 13-146 (152) alignment 
Range on Protein: 2-142
Range on HMM: 13-146/152.0
VEILPGLLLGGMsDVQYLLRRKSTVKLTHLLSVVKEAldwSDLhspSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
.|. | |.|| . || .  .  .. |.||.|.|  .     ..    |  . .. |. .||| |||| ...||.|||.|. .. |..||||. | ||||.
geveprlylgsq.dvaadkeilkekkitHilnvatgv...pnv...fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsas

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLW
.||||..| ...|..||.. |.|..| |.||.||| ||| .
vviaylmkkeelsleealelvrearpcikPneGFikqLkey
PTPc_motif_SM00404 2-145 1.1e-33 111.0 In-house 3-140 (140) alignment 
Range on Protein: 2-145
Range on HMM: 3-140/140.0
VEILPGLLLGGMSDVQyLLRRKSTVKLTHLLSVVKEAlDWSdlhsPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
 .|||.| ||. |. |  .. .. ...|| ..| .|  ...     .   .  . |.  |  ...|. ......|||..  ..||..||||  |.|||||
srilphlylgskskaq.npallkklgithvinvteev.slt....kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSat

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYKM
..||| ..|...| .||..||||..| |.||..|. ||  ..|.
liiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
0044763 (Phosphotyrosine protein) phosphatases II 2-146 2e-32 107.7 In-house 24-170 (178) alignment 
Range on Protein: 2-146
Range on HMM: 24-170/178.0
VEILPGLLLGGMSDvQYLLRRKSTVKLTHLLSVVKEALDWS---DLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETM-DTGGTILVHCEYGLS
.||||||.||.  . .  |.     ..||.... .|   .    |   |.   |  . |   | . .||| ||.|...||.| . . ||..|||| .|..
seilpglylgslpp.addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

RSATIVIAYFIKYHKMSFNEAIDFVKEKKPdIRPNAGFISQLKLWYKMK
||.|.|.|| .|....|..|||..|.|..| | || |.. ||...... 
RsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
DSPc Dual specificity phosphatase, catalytic domain 12-144 3.8e-31 102.7 Pfam-A 5-132 (133) alignment 
Range on Protein: 12-144
Range on HMM: 5-132/133.0
GMSDVQylLRRKSTVKLTHLLSVVKEALDWsdlHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYH
. |. .  |. .. ...|. ..| ||       .. ... |    |.  |  .|..  ...||..||.. .. |...||||. |.|||||..||| .|..
skstas..lalleklgitlvinvtkevpnn...naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

KMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYK
..| |||..||||... |.|||||. ||  ...
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 12-144 3.8e-31 102.7 In-house 5-132 (133) alignment 
Range on Protein: 12-144
Range on HMM: 5-132/133.0
GMSDVQylLRRKSTVKLTHLLSVVKEALDWsdlHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYH
. |. .  |. .. ...|. ..| ||       .. ... |    |.  |  .|..  ...||..||.. .. |...||||. |.|||||..||| .|..
skstas..lalleklgitlvinvtkevpnn...naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

KMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYK
..| |||..||||... |.|||||. ||  ...
nlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP1_pd Subfamily DSP1 4-147 1.1e-29 97.6 In-house 21-157 (163) alignment 
Range on Protein: 4-147
Range on HMM: 21-157/163.0
ILPGLLLGGMSDVQYLlRRKSTVKLTHLLSVVKEALDWSDLhspspgPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIV
||. | ||. ..   | .  .. ..|..| | ||  .  .         . | ..  | |. |.  .| |. .||.|  ...| .|.||. |.|||.|..
ildfLylGsetvasnl.eiLkslgitailnvskeldnvfed......lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlc

IAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYKMKG
.||..| ...|..|| ||||.... |.|||||. ||. . |  .
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP6_pd Subfamily DSP6 2-144 6.2e-29 94.5 In-house 15-152 (158) alignment 
Range on Protein: 2-144
Range on HMM: 15-152/158.0
VEILPGLLLGGMSDVQYLlRRKSTVKLTHLLSVVKEAldwSDLHSpSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
||||| | ||   | . |    . .|. ..| | ..     . .  . | .  . | . |  |..|  .|||| .||.|.  .  ..||||  |.||| |
veilpllylGsakdasnl.evlkklkikyvlnvtsnl...pnkfe.esgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYK
...||..|....|.|.| |.||..|..| ||  |. ||. . .
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfer
0049772 (Phosphotyrosine protein) phosphatases II 52-158 6.7e-29 97.0 In-house 181-285 (314) alignment 
Range on Protein: 52-158
Range on HMM: 181-285/314.0
ISCKLIQAIDlPSTDLLIHFPEATDFIQETmDTGGTILVHCEYGLSRSAT-IVIAYFIKYHKMSFNEAIDFVKEKKPdIRPNAGFISQLKLWYKMKGTLN
|  . |   | .|..|| .|.|. .||.|  |.|| .||||  | .|..| .|.|| .|....|..||...|..| | |.|| ||| ||......   |.
ikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefileall

ETDKSYKS
|  | .|.
eylkflkk
subfamily_DSP10_pd Subfamily DSP10 1-141 2.4e-28 93.0 In-house 14-148 (159) alignment 
Range on Protein: 1-141
Range on HMM: 14-148/159.0
MVEILPGLLLGGMSDVQYLLRRkSTVKLTHLLSVVKEAldwSDLHSPspGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSA
....|| |.||   | . |     . ..|..| | ..       ..     .. | |.. |  . .|  .| || .||.|   .| ..||||. |.||||
asqvlpfLflGsekdaadldal.drlnitavlnvttsv...Pnefee..ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsa

TIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKL
|.|||| .|. ..|.|.| .|||||.| | || .|. ||. 
tvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLle
0048179 (Phosphotyrosine protein) phosphatases II 2-144 1.4e-27 91.5 In-house 5-142 (144) alignment 
Range on Protein: 2-144
Range on HMM: 5-142/144.0
VEILPGLLLGGMSDVQYLLRRKStVKLTHLLSVVKEaldwSDLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
.|||||| ||.. ... | . |.  ..|...... |     . ... .  |    .   | .  ||| ...|. .||.| .. || .|||| .|..|..|
seilpglylgslptaldlellkk.lgittvinltee....yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgt

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYK
.|.|| .|....|..||...|... | . || |.. .|....|
lvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_DSP3_pd Subfamily DSP3 52-140 2e-27 89.8 In-house 63-151 (162) alignment 
Range on Protein: 52-140
Range on HMM: 63-151/162.0
ISCKLIQAIDLPSTDLLIHFPEATDFIQETMDT-GGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKpDIRPNAGFISQLK
|    ... | |..||  .| .|..||.|....  | .||||. |.|||||.|.|| . ..||. .|||  |..|. .|.|| ||. ||.
ikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLa
subfamily_DSP14_pd Subfamily DSP14 2-142 2.4e-27 89.8 In-house 8-140 (157) alignment 
Range on Protein: 2-142
Range on HMM: 8-140/157.0
VEILPGLLLGGMSDVQYLLRRKStvKLTHLLSVVKEALDwSDLHSPSpgpisCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
..| | | |.|.. ..  | .|   |.|. . |  |. .  .|.. .        ... | |...|  || |..| |.|   .|| .||||  | ||||.
sqitpsLflsgvaalskellkkk..kitliinvtvelpn.tklkdie.....rvkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAs

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLW
...|| .||.|.| .||   ||...| |||| || .||  .
lclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidy
0048076 (Phosphotyrosine protein) phosphatases II 2-145 2.6e-27 90.6 In-house 5-141 (145) alignment 
Range on Protein: 2-145
Range on HMM: 5-141/145.0
VEILPGLLLGGMSDVQYLLRRKStVKLTHLLSVvkealdWSDLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
 |||||| ||.. ... | . |.  ..|..|..       |.|. ...  |    .   | .  ||| ...|. .||.| .. || .||||  |..|..|
seilpglylgslptaldlellkd.lgittvlnl......tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgt

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYKM
.|.|| ......|. ||...|... | . || |.. .|......
lvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_DSP15_pd Subfamily DSP15 1-146 1.4e-26 87.4 In-house 2-139 (151) alignment 
Range on Protein: 1-146
Range on HMM: 2-139/151.0
MVEILPGLLLGGMSDVQYLLRrKSTVKLTHLLSVVKealdwsdLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSA
. ..|||| ||.. | .   .  .  ..||.|||            .    |. |.|.| | ||..|  .| |. .|| ..   ....||||  |.|||.
iskvlpglylgnfrdskdeel.Lkeknithilsvhd.......nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsv

TIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYKMK
|.|.||..   ......|....|...    ||.|| .||| . |.|
tlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektk
subfamily_Slingshot_pd Subfamily Slingshot 49-144 8.7e-26 84.3 In-house 60-155 (169) alignment 
Range on Protein: 49-144
Range on HMM: 60-155/169.0
PGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYK
|. .. . |.  | ..|||| .. |. .||... ..|  .||||  |.||||..|||| .| ...|..||...|||..  |.||.||..||. .  
pekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeG
0041856 (Phosphotyrosine protein) phosphatases II 2-147 1.3e-25 85.4 In-house 20-173 (182) alignment 
Range on Protein: 2-147
Range on HMM: 20-173/182.0
VEILPGLLLGGMSD-------------VQYLLRRKSTVKLTHLLSVVkealdwSDLHSPSPGP---ISCKLIQAIDLPSTDllihFPEATDFIQETMDTG
 .|...|.||.. .             |   ||     . |.....       ..|. |.  .   |  . ..  | . .|    ..|. |||.|  . |
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeg

GTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKP--DIRPNAGFISQLKLWYKMKG
|..|||| .|..|..|.|.||..|....|. ||...|....|   |.|| .|. ||.|......
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 3-142 1.4e-25 83.8 In-house 122-254 (263) alignment 
Range on Protein: 3-142
Range on HMM: 122-254/263.0
EILPGLLLGGMSDVQYlLRRKSTVKLTHLLSVVkealdwSDLHSPSPGPISCKLI-QAIDLPSTDLLIHFPEATDFIQETMDTGGtILVHCEYGLSRSAT
||...| |||.   .       .  .||.|  |      .|..   |       | .. | .  |.  || |   ||.|  . || .||||  |.|||.|
eiidklflGgldsann.ksilkdlgvthillav......adfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsst

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLW
.||.|..|.... |.||.|.|..|.| |.|| ||. ||| .
lvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkky
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 60-143 1.9e-24 79.9 In-house 61-144 (148) alignment 
Range on Protein: 60-143
Range on HMM: 61-144/148.0
IDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWY
 | |  ||   |.....|.... | |...|||.. | |||. ......|.....| .||...||.|.. ..|| ||..||  . 
dDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaele
0043147 (Phosphotyrosine protein) phosphatases II 25-145 1.4e-23 78.9 In-house 42-159 (172) alignment 
Range on Protein: 25-145
Range on HMM: 42-159/172.0
TVKLTHLLSVVKEaldWSDLHSPSPGPISCKLIQAIDLPSTdLLIHFPEATDFIQE--TMDTGGTILVHCEYGLSRSATIVIAYFIKyHKMSFNEAIDFV
. . ||.... ..     |    ..  |    .   | . . || ...|. .||.|    . ||..|||| .|..|..|.|.|| .. ...|. ||...|
elgithivnltel...lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalv

KEKKPDIRPNAGFISQLKLWYKM
.||.| . .| ... .|. . |.
rekRpgavqnpsqyrflyyfekl
subfamily_MKPLT_pd Subfamily MKPLT 21-145 2.2e-23 76.6 In-house 41-159 (164) alignment 
Range on Protein: 21-145
Range on HMM: 41-159/164.0
RRKSTVKLTHLLSVVKEALDwsdlhsPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAID
.    .|.|| . | .| .|        |  .    ..  | . . |  ..  |..|. ...|.||..||||  | |||... .|. ||...  ..|| .
kvlkdlkithivnvsqekkd......afpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeaye

FVKEKKPDIRPNAGFISQLKLWYKM
..||..  ..|| ||. ||  . ..
ylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 21-145 2.2e-23 76.6 In-house 41-159 (164) alignment 
Range on Protein: 21-145
Range on HMM: 41-159/164.0
RRKSTVKLTHLLSVVKEALDwsdlhsPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAID
.    .|.|| . | .| .|        |  .    ..  | . . |  ..  |..|. ...|.||..||||  | |||... .|. ||...  ..|| .
kvlkdlkithivnvsqekkd......afpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeaye

FVKEKKPDIRPNAGFISQLKLWYKM
..||..  ..|| ||. ||  . ..
ylkerrsivapnrGflkqlakfeel
PTEN_1 4-143 3e-23 77.7 In-house 44-188 (196) alignment 
Range on Protein: 4-143
Range on HMM: 44-188/196.0
ILPGLLLGGMSDV-QYLLRRKSTvKLTHLLSVVKEALD--WSDLHSP-SPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETM--DTGGTILVHCEYGLS
| .||..| ..|| ..| ..|.  ..|.....  |  .   |. ..    . .. . .   | .  .|  .| .. .||.     . |...||||  ||.
ideglyrgslkdvaadldnlked.gitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWY
||.|.|.|| ....|....||...|.|| | ..|| ..  .|.  .
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyf
subfamily_STYXL1_pd Subfamily STYXL1 2-145 3.1e-23 75.7 In-house 12-152 (157) alignment 
Range on Protein: 2-145
Range on HMM: 12-152/157.0
VEILPGLLLGGMSDVQYLLRRKSTVKLTHLLSVVKEALDwsdLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
||.||| |  |     .  . |  .|.   . | ..| .   | .  ..      |.  | . .||| .. || .||..   .| ..||  . |.||||.
vevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadk...liagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaa

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYKM
..|||.. ..|.....| ...|. |....|| .|..||. | |.
viiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq
subfamily_STYX_pd Subfamily STYX 1-143 3.4e-23 75.6 In-house 12-154 (166) alignment 
Range on Protein: 1-143
Range on HMM: 12-154/166.0
MVEILPGLLLGGMSDVQ-YLLRRKSTVKLTHLLSVvKEALDWSDLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRS
| |||||| ||  |  .   |       .||.. . ..... . ..   |  .   ...  | .  ... ..|.  .||......|| .||| . |.|||
mqeilpglflgpysaamksklevlkkhgithivci.rqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

ATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWY
|..||||... . . . ||  .|.|..  | ||.||.|||| . 
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye
0046846 (Phosphotyrosine protein) phosphatases II 2-145 3.6e-23 77.7 In-house 13-171 (176) alignment 
Range on Protein: 2-145
Range on HMM: 13-171/176.0
VEILPGLLLGGMS---------DVQYLLRRKSTVKLTHLLSVVKE--------ALDWSDLHSPSPgpiSCKLIQAIDLPSTDLlIHFPEATDFIQETMDT
..|...|.||..          ...  |..    . |..... .|        . .|..|....      . .   |    ||  ...|. .||.|  . 
dyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...qylhlpwpDhgvpdl.elllellefirealke

GGTILVHCEYGLSRSATIVIAYFIKY-HKMSFNEAIDFVKEKKP-DIRPNAGFISQLKLWYKM
||..||||  |..|..|.|.|| ... . .| .||...|.|..|  . .. ... .|. ....
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
subfamily_DSP8_pd Subfamily DSP8 66-144 1.5e-22 73.9 In-house 74-152 (159) alignment 
Range on Protein: 66-144
Range on HMM: 74-152/159.0
DLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYK
.||  |.....||. .  . |..|||.  | |||||..||| .|. .||..||  |||||.| | ||  |. ||  ..|
kllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyek
0045098 (Phosphotyrosine protein) phosphatases II 55-144 2e-22 75.4 In-house 162-269 (278) alignment 
Range on Protein: 55-144
Range on HMM: 162-269/278.0
KLIQAIDLPSTDLLIHFPEATDFIQETMD--------------TGGTILVHCEYGLSRSATIVIAYFIKYH---KMSFNEAIDFVKEKKPD-IRPNAGFI
. .   . ||...| .| |...||.| ..               ||..|||| .|..|..|.|.|| ....   .... ||........|  . .| ...
lpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqy

SQLKLWYK
 .|  .  
rflyefll
0049260 (Phosphotyrosine protein) phosphatases II 30-144 4.5e-22 73.8 In-house 36-147 (152) alignment 
Range on Protein: 30-144
Range on HMM: 36-147/152.0
HLLSVVKEALDWSDLHSPSPgpiSCKLIQAIDLPSTDLLIHFPEATDFIQE-TMDTGGTILVHCEYGLSRSATIVIAYFIKyHKMSFNEAIDFVKEKKPD
..... ..  .. . .   .     . ..  | .  || ...... .||..   | ||..|||| .|..|..|.|.|| .. ...|. ||...|.||.| 
tivmltellelgklkceqyi...qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpg

IRPNAGFISQLKLWYK
. || |.. .|. ..|
avpnpgqlrflyefek
0040439 (Phosphotyrosine protein) phosphatases II 47-142 1.5e-21 72.6 In-house 135-241 (249) alignment 
Range on Protein: 47-142
Range on HMM: 135-241/249.0
PSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMD------TGGTILVHCEYGLSRSATIVIAYFI-----KYHKMSFNEAIDFVKEKKPDIRPNAGF
  . .. .. || .|.| ...  .|... |||.. ..      .|| .||||  |..|..|...|| .     |...... ||........| . .| ..
ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeq

ISQLKLW
. .|  .
yrflyea
0038934 (Phosphotyrosine protein) phosphatases II 60-145 3.2e-21 71.3 In-house 91-175 (194) alignment 
Range on Protein: 60-145
Range on HMM: 91-175/194.0
IDLPSTDLLIHFPEATDFIQETmDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYKM
.  ||...| .| .. |.. .  |.||...||| .||.|..|.|.|| |....|| .|||....||.|.. || .....|  .||.
gtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryke
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 57-145 3.8e-21 69.1 In-house 61-151 (154) alignment 
Range on Protein: 57-145
Range on HMM: 61-151/154.0
IQAIDLPSTDLLIHFPEATDFIQETM--DTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYKM
..  | .  |.. ..  | .||....     . .|||.. |.||||...|.|...  |.|. .|. ..|. .. |.|| ||. ||. . | 
lelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifeke
0036282 (Phosphotyrosine protein) phosphatases II 4-142 2.4e-20 68.4 In-house 15-165 (174) alignment 
Range on Protein: 4-142
Range on HMM: 15-165/174.0
ILPGLLLGGMSDVqyLLRRKSTVKLTHLLSVVKEALDW---------SDLHSPSPGPISCKLIQAIDLPSTDLLIhFPEATDFIQETMDT--GGTILVHC
|.|.|..|.       ..     ..|..... .|  .          .. .....  |  . .   |    || | . |. .|..| .    ||..||||
itprliagqgpla..fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

EYGLSRSATIVIAYFIKYHKM-SFNEAIDFVKEKK---PDIRPNAGFISQLKLW
  |..|..|.|.|| ...... |. .|.|.|.|..   | . .. ... .|  .
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
0045450 (Phosphotyrosine protein) phosphatases II 47-142 4.3e-20 68.1 In-house 190-299 (307) alignment 
Range on Protein: 47-142
Range on HMM: 190-299/307.0
PSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMD------TGGTILVHCEYGLSRSATIVIAYFIKYHK--------MSFNEAIDFVKEKKPDIRPN
..  .. .. .. .. | ...  .| |. |||.| ..       || .||||  |..|..|...|| ....         ... ||.....|..| . .|
gtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqn

AGFISQLKLW
 ... .|  .
peqyrflyea
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 52-139 7.8e-20 64.5 In-house 47-134 (145) alignment 
Range on Protein: 52-139
Range on HMM: 47-134/145.0
ISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQL
|.  || | || | ||  || | ||||.   . |  ..|||  |.||| |. .|...|| .|.. ||   |. ..    ||  |. .|
ieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknl
0037934 (Phosphotyrosine protein) phosphatases II 60-144 3.5e-19 64.8 In-house 146-239 (243) alignment 
Range on Protein: 60-144
Range on HMM: 146-239/243.0
IDLPS--TDLLIHFPEATDFIQE-----TMDTGGTILVHCEYGLSRSATIVIAYFIKYH-KMSFNEAIDFVKEKKPD-IRPNAGFISQLKLWYK
 . |.  .||| .. |...||.|     . |.||..||||  |..|..|...|| .... .... ||.....|..|  . .. ... .|  ...
hgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_MSG5_pd Subfamily MSG5 69-145 6.7e-19 61.6 In-house 83-159 (165) alignment 
Range on Protein: 69-145
Range on HMM: 83-159/165.0
IHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYKM
  ... |  |  .   .  |||||. ||||||....|| .||...|...| | .| .  || |. |.| ||  |  .
kdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweva
0040438 (Phosphotyrosine protein) phosphatases II 51-165 1.8e-18 62.3 In-house 171-294 (317) alignment 
Range on Protein: 51-165
Range on HMM: 171-294/317.0
PISCKLIQAIDLPSTDLLIHFPEATDFIQETMDT----GGTILVHCEYGLSRSATIVIAYFI-----KYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKL
.  .. .. .. |  ..  .. .  ||...  .     || .||||  |..|..|...|| .     |...... ||.....|..| . .. ... .|  
srtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyd

WYKMKGTLNETDKSYKSYRLSHQA
.  .  . ..|....... | .. 
alleylkrkltlepaselklkllk
0042113 (Phosphotyrosine protein) phosphatases II 60-143 1.7e-17 59.1 In-house 149-239 (245) alignment 
Range on Protein: 60-143
Range on HMM: 149-239/245.0
IDLPSTDLLIHFPEATDFIQETMD--TGGTILVHCEYGLSRSATIVIAYFI-----KYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWY
 | . .||| .. .. .|... .    .|..||||  |..|..|...|| .     |....|. ||........| .... ... .|  . 
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0051082 (Phosphotyrosine protein) phosphatases II 6-143 2.7e-17 58.2 In-house 13-150 (151) alignment 
Range on Protein: 6-143
Range on HMM: 13-150/151.0
PGLLLGGMSdVQYLLRRKSTVKLTHLLSVVKEALDWSDLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDT-GGTILVHCEYGLSRSATIVI
.||...|.   .  |.   . .... ... .|     . .      |  . |. .| | ..| ..|... .|... .|. .| .||||  |..|..|.|.
gglyrsggp.ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlva

AYFIKyHKMSFNEAIDFVKEKKP-DIRPNAGFISQLKLWY
.| .. ...|..||......| |  ..|| .|. ||. ..
lylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall
0036941 (Phosphotyrosine protein) phosphatases II 48-145 3.4e-17 58.1 In-house 164-275 (297) alignment 
Range on Protein: 48-145
Range on HMM: 164-275/297.0
SPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMD------TGGTILVHCEYGLSRSATIVIAYFI--------KYHKMSFNEAIDFVKEKKPDIRPNA
.. .  .. .. .. |  ..  .. .  |||..  .       || .||||  |..||.|...|. .        |...... ||. ...|..| . .. 
ngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl

GFISQLKLWYKM
..  .|  .  .
eqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 61-143 5.3e-17 57.7 In-house 195-285 (297) alignment 
Range on Protein: 61-143
Range on HMM: 195-285/297.0
DLPSTDLLIHFPEATDFIQETMD---TGGTILVHCEYGLSRSATIVIAYFI-----KYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWY
|    ..| .. |. ....| .     || .||||  |..|..|...|| .     |...... ||.....|..| .... ... .|  . 
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
subfamily_PTPMT1_pd Subfamily PTPMT1 69-144 8.7e-16 52.8 In-house 91-166 (171) alignment 
Range on Protein: 69-144
Range on HMM: 91-166/171.0
IHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYK
 .  .. .||......| .. |||. | .||||.|..| .| .|.| .||....|.|.. || .    ..|. ...
eklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee
0043336 (Phosphotyrosine protein) phosphatases II 60-141 3e-14 48.6 In-house 181-271 (278) alignment 
Range on Protein: 60-141
Range on HMM: 181-271/278.0
IDLP------STDLLIHFPEATDFIQEtmDTGGTILVHCEYGLSRSATIVIAYFI-----KYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKL
.. |      |..||..| .| . ..|  | .| .||||  |..|..|....| .     |...... ||.....|..| . ..  .. .|  
lgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0047943 (Phosphotyrosine protein) phosphatases II 61-139 5.9e-13 44.3 In-house 175-264 (273) alignment 
Range on Protein: 61-139
Range on HMM: 175-264/273.0
D-----LP-STDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFI-----KYHKMSFNEAIDFVKEKKPDIRPNAGFISQL
.      | |.. |..| |. . ..|.   .|...|||  |..|..|..... .     |...... ||. ......| . ..  .. .|
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051429 (Phosphotyrosine protein) phosphatases II 65-144 7.1e-12 41.1 In-house 83-222 (272) alignment 
Range on Protein: 65-144
Range on HMM: 83-222/272.0
TDLLIHF------------------------------------------------PEATDFIQETMDtGGTILVHCEYGLSRSATIVIAYFIKyHKMS--
.. |...                                                 .  .....  | || .||||  | .|..|.| .. .  . .|  
ptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsle

------------FNEAIDFVKEKKPDIRPNAGFISQLKLWYK
              ||.. .... | .... ... .|  ...
tivddYlltnlyleeaveelraqrpgavqteeqylflyeall
0051299 (Phosphotyrosine protein) phosphatases II 48-132 4.2e-11 38.3 In-house 178-271 (288) alignment 
Range on Protein: 48-132
Range on HMM: 178-271/288.0
SPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDT----GGTILVHCEYGLSRSATIVIAYFI-----KYHKMSFNEAIDFVKEKKPDIRPN
.  .. .. .. .. |  .   .. .  ||... ..     ||...|||  |..|..|..... .     | ..... ||. ...|..| . ..
dgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
0046845 (Phosphotyrosine protein) phosphatases II 62-128 6.5e-11 37.6 In-house 180-255 (284) alignment 
Range on Protein: 62-128
Range on HMM: 180-255/284.0
LP-STDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYH--------KMSFNEAIDFVKEKKPD
 | |.. |..| .. . ..| ...||.|.|||  |..|..|..... ....        .... ||. ...|..| 
vppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg
0050432 (Phosphotyrosine protein) phosphatases II 48-128 1.6e-10 36.3 In-house 193-280 (308) alignment 
Range on Protein: 48-128
Range on HMM: 193-280/308.0
SPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDT--GGTILVHCEYGLSRSATIVIAYFI-----KYHKMSFNEAIDFVKEKKPD
..  . .. .. .. |  .   .. .  ||...  ..  ||.|.|||  |..|..|..... .     | ..... ||. ...|..| 
dgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg
0048567 (Phosphotyrosine protein) phosphatases II 76-131 1.2e-09 32.8 In-house 65-123 (157) alignment 
Range on Protein: 76-131
Range on HMM: 65-123/157.0
DFIQETMDTGGTILVHCEYGL---SRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRP
.|.. .  .|..| ||| .||   .|.||.. .| |...... .|||....   |.. |
kflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp
subfamily_CDC14_pd Subfamily CDC14 76-127 7.4e-09 29.9 In-house 254-305 (328) alignment 
Range on Protein: 76-127
Range on HMM: 254-305/328.0
DFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKP
 |.. . .. |.| |||  || |  |.. .|..| .... .||| ...  .|
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP
subfamily_DSP23_pd Subfamily DSP23 75-127 1.1e-08 29.9 In-house 74-126 (148) alignment 
Range on Protein: 75-127
Range on HMM: 74-126/148.0
TDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKP
   ..|. . . .. |||  |  |. |..  |..| .|..  |||  |....|
vrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrp
subfamily_RNGTT_pd Subfamily RNGTT 83-143 7.7e-08 26.2 In-house 111-171 (189) alignment 
Range on Protein: 83-143
Range on HMM: 111-171/189.0
DTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAID-FVKEKKPDIRpNAGFISQLKLWY
 .  .| ||| .|  |.  ....| .. ...| ..|.. | | ..| |  .  ....|   |
npeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiy.kedylkellrrY
PTPc_DSPc_SM00012 40-123 8.8e-08 27.7 In-house 9-71 (105) alignment 
Range on Protein: 40-123
Range on HMM: 9-71/105.0
DWSDLHSPSPGPISCKLIQAIDLPSTDLLIhfpeatdfiqetmdtGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNeaidfvK
.|.| . |...   ..|..|..   ..                  .. ..|||  | .|..|.| .. .  . .. .      |
gwpdhgvPeesdsilellravkknknkses...............skpvvVhCsaGvgRtgtfvaldillqqleket......k
subfamily_PTPDC1_pd Subfamily PTPDC1 81-128 8.9e-08 26.8 In-house 111-157 (182) alignment 
Range on Protein: 81-128
Range on HMM: 111-157/182.0
TMDTGgTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPD
... |  . |||  || |   .. .|..  .... ..||..|..|.|.
alqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk
subfamily_DSP11_pd Subfamily DSP11 62-124 3.3e-07 24.4 In-house 92-155 (178) alignment 
Range on Protein: 62-124
Range on HMM: 92-155/178.0
LPSTDLLIHFPEA-TDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKE
.|. .|. .| || ..|.... |..  | |||  |. |.  ..  |.|. . .. ..||.  .|
vpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafee