Gene DSP15 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP15
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP008_AA protein Get Run
AqueP008_AA_2-146 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP15_pd Subfamily DSP15 5-155 9.6e-69 224.3 In-house 2-151 (151) alignment 
Range on Protein: 5-155
Range on HMM: 2-151/151.0
IDKVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPEnFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYL
|.||..|||.|... ....||| |.||||.|.| |||...... ..||||..||.||..|| .|||||.||||||.......|||.||.||||||...||
iskvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTILNDERKRLKSEF
||.|.|...||..|. .|||.| |||||..|...|.|| |...||.||.||
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrkqlkeef
subfamily_DSP1_pd Subfamily DSP1 5-146 3.4e-43 141.6 In-house 18-159 (163) alignment 
Range on Protein: 5-146
Range on HMM: 18-159/163.0
IDKVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYL
. |.   ||.|. . ||..|.| ...||..| |  . . .|.. |.||..|..|||. |.|..|.| ..||.... ..|  ..||.|||||| ||| .||
vekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTILND
|. . .|.|.|.. .   ||.  ||.||  |...| |..|..
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
subfamily_DSP19_pd Subfamily DSP19 5-143 2.5e-37 122.5 In-house 12-150 (152) alignment 
Range on Protein: 5-143
Range on HMM: 12-150/152.0
IDKVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYL
. .|   ||.| . .|..|| | |..|||.| |  . . .||..|.|..|.| | |  ||. ..||..|||.. | . |  .||| ||.|||...   ||
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTI
|. ..||.|.|....  ||  . || ||  |. .| ...
mkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP12_pd Subfamily DSP12 5-145 5.6e-36 118.3 In-house 2-145 (155) alignment 
Range on Protein: 5-145
Range on HMM: 2-145/155.0
IDKVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPH---FPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCT
.... .|||.||.  . ..||| | .|||||.|  .. |.    . . ..| |.| |.|. |.  |. | ||||.... |.|. .|||.||.|||||...
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

VYLMTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTILN
 |||  . || |.|. ..  ... . || ||  |.  . |   .
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck
subfamily_LRR-DSP_pd Subfamily LRR-DSP 6-143 1.1e-35 117.0 In-house 121-258 (263) alignment 
Range on Protein: 6-143
Range on HMM: 121-258/263.0
DKVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPENFQYKCI-KISDSPSCDLSVHFKESVDFIHKCRIEGGsCYVHCAAGISRSVTLCTVYL
|..  .|..||   |  | .| ....||.|  . . || ||. |.|  | .| | .  |.| ||.|   ||.. | .||   ||| ||.||| ||   ||
deiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisyl

MTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTI
|    | ...|. ...  |.   || ||. |..|| | .
mkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
PTPc_motif_SM00404 6-141 2.2e-35 116.6 In-house 3-139 (140) alignment 
Range on Protein: 6-141
Range on HMM: 3-139/140.0
DKVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEP-HFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYL
 ..  .||.|..  |....|| ...||||. | .. .     ..||...|...|. . .|| .... .|||.... .||...|||.||.|||.||...||
srilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYl

MTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTK
|.   ||...|. .. . |..  ||..|  |...| |
mryrqlslaeayefvkerRpiispnlnfvrqLieyek
0044763 (Phosphotyrosine protein) phosphatases II 5-145 3.1e-35 116.8 In-house 23-172 (178) alignment 
Range on Protein: 5-145
Range on HMM: 23-172/178.0
IDKVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPEN---------FQYKCIKISDSPSCDLSVHFKESVDFIHKCR-IEGGSCYVHCAAGIS
....  |||.|.   |. .||| |..|||.. . .. |..|...         .||..| |.|.. .||. || | |.||....  .|| ..||| ||..
aseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

RSVTLCTVYLMTATTLSYEDAMTVMVYARSmAGPNFGFRMQMMKYTKTILN
|| ||.  |||    ||.|.|.  .  .|. . ||.|.. |.... . .|.
RsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP14_pd Subfamily DSP14 4-147 4e-34 111.8 In-house 6-148 (157) alignment 
Range on Protein: 4-147
Range on HMM: 6-148/157.0
SIDKVCTGLYVGgIMGASKKELLLENNITHVLAVLDNAEPHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVY
.. ..   |...  ..|..|||| ...||... |  ..  .  .....  ....|.|. .|. || | .| |.. . .|| . |||.||.||| .||..|
alsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

LMTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTILNDE
||   .|| ..| ...  ||..  || ||  |...| | . .. 
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
0048076 (Phosphotyrosine protein) phosphatases II 5-142 7.2e-33 108.6 In-house 4-141 (145) alignment 
Range on Protein: 5-142
Range on HMM: 4-141/145.0
IDKVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYL
..... |||.|..  |.. ||| ...||.|| . .. | ......|| .. . | .  ||. .. | ..||.... ||| ..||| ||..|. ||.  ||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKT
|    .|.|.|.  .  .|..| ||.|.. ..... . 
mlllgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 5-141 4.6e-32 106.1 In-house 4-142 (144) alignment 
Range on Protein: 5-141
Range on HMM: 4-142/144.0
IDKVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPENF--QYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTV
..... |||.|..  |.. ||| ...||.|. . .. ||.|.|..  || .. . | .  ||. .. | ..||.... ||| ..||| ||..|. ||.. 
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTK
|||    ||.|.|.  .  .|..| ||.|.......| |
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
DSPc Dual specificity phosphatase, catalytic domain 12-141 6.4e-32 105.2 Pfam-A 1-132 (133) alignment 
Range on Protein: 12-141
Range on HMM: 1-132/133.0
LYVGGIMGASkKELLLENNITHVLAVLDNAEP-HF--PENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTAT
||.|.   || ..|| ...||.|. | .. .  ..  .....| .|.. |. . ..| ...|.|.||.|.. .|....|||.|||||| ||...|||.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

TLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTK
 ||...|. .. . ||.  ||.||  |...| .
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 12-141 6.4e-32 105.2 In-house 1-132 (133) alignment 
Range on Protein: 12-141
Range on HMM: 1-132/133.0
LYVGGIMGASkKELLLENNITHVLAVLDNAEP-HF--PENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTAT
||.|.   || ..|| ...||.|. | .. .  ..  .....| .|.. |. . ..| ...|.|.||.|.. .|....|||.|||||| ||...|||.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

TLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTK
 ||...|. .. . ||.  ||.||  |...| .
nlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP6_pd Subfamily DSP6 8-143 7.2e-32 104.1 In-house 17-154 (158) alignment 
Range on Protein: 8-143
Range on HMM: 17-154/158.0
VCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPE--NFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLM
. . ||.|    ||. |.| . .| .|| |  | .  | |  ...|. | |.|  | .|. .| |...|| . | .  .. ||| ||||||||..  |||
ilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylm

TATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTI
  ..|| .||  ..   .|   ||| |  |.... ...
kklalslndaydlvkkrksnisPnfnfmgqlldfersl
subfamily_DSP10_pd Subfamily DSP10 7-145 1.1e-30 100.6 In-house 16-155 (159) alignment 
Range on Protein: 7-145
Range on HMM: 16-155/159.0
KVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPE-NFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLM
.| . |..|   .|.....| . |||.|| |  .   .| | ...|| |..||. . .|. .|.|...||.. | .| .  ||| ||||||.|.   |||
qvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlm

TATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTILN
. ..|| .||   .  .|..  ||..|  |.... |.. .
khlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
0043147 (Phosphotyrosine protein) phosphatases II 7-143 4.3e-30 100.1 In-house 21-160 (172) alignment 
Range on Protein: 7-143
Range on HMM: 21-160/172.0
KVCTGLYVGGIMGASKKELLLENNITHVLAVLDN---AEPHFPENFQYKCIKISDSPSCdLSVHFKESVDFIHK--CRIEGGSCYVHCAAGISRSVTLCT
..  ......   |.  ..| |..|||.. . .    .|. .....|| .. . | . . |. .. | ..||..  .. .|| ..||| ||..|..||. 
rfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlva

VYLMTaTTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTI
 |||    ||.|.|.  .  .|..| .|...... ... |..
aylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0041856 (Phosphotyrosine protein) phosphatases II 5-144 9.5e-29 95.7 In-house 19-173 (182) alignment 
Range on Protein: 5-144
Range on HMM: 19-173/182.0
IDKVCTGLYVGGIMG--------------ASKKELLLENNITHVLAVLdnAEPHFPENF-----QYKCIKISDSPSCDlsvhFKESVDFIHKCRIEGGSC
.|..  .||.|.  .              |.  ..| |..||... .    |...||..     ||... . | . .|    . | .|||.... ||| .
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpv

YVHCAAGISRSVTLCTVYLMTATTLSYEDAMTVMVYARS--MAGPNFGFRMQMMKYTKTIL
.||| ||..|. ||.  |||    .|.|.|.  .  .|.     ||..|  |.. . .  |
lVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Slingshot_pd Subfamily Slingshot 7-151 2.5e-28 92.6 In-house 21-164 (169) alignment 
Range on Protein: 7-151
Range on HMM: 21-164/169.0
KVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMT
|.   .|.|    ||. | | ||.....| |  . . .|||.|.|. |.. |... ||  ...|. .||.|.. .| .. |||  |.||| .    | | 
kifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamk

ATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYtKTILNDERKRL
.  ||.|.|.. .   ||.. || ||  |. .| . ||. ...| 
eyglsleealeyvkerrsvikPnkgflkqleey.eGileaskqrh
0049260 (Phosphotyrosine protein) phosphatases II 11-141 9.9e-28 92.1 In-house 14-147 (152) alignment 
Range on Protein: 11-141
Range on HMM: 14-147/152.0
GLYVGGIMGASKKELLLENNITHVLAVLDNAEP---HFPENFQYKCIKISDSPSCDLSVHFKESVDFIHK-CRIEGGSCYVHCAAGISRSVTLCTVYLMT
....|.   |. ...| |..||... . .  |     ... .||... . |.. .||| .... ..||.| .. .|| ..||| ||..|. ||.  ||| 
tqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml

aTTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTK
   .|.|.|.  .  .|..| ||.|.... ... |
.lgvsleeavalvrekRpgavpnpgqlrflyefek
0045098 (Phosphotyrosine protein) phosphatases II 4-141 5.6e-27 90.3 In-house 21-269 (278) alignment 
Range on Protein: 4-141
Range on HMM: 21-269/278.0
SIDKVCTGLYVGGIM-----------------------------------------GASKKELLLENNITHVLAVL------------------------
..... ..||.|..                                           |.  ..| |..||... .                         
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

----------------------------DNAEPHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRI--------------EGGSCYVHCAAGISRS
                             . |... . ..|...   ..|| ... .| | ..||....               .|| ..||| ||..|.
ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRt

VTLCTVYLMTAT---TLSYEDAMTVMVYARSM-AGPNFGFRMQMMKYTK
 ||. .|||      ......| . .   | . | .|... ......  
GtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefll
subfamily_DSP3_pd Subfamily DSP3 3-144 5.7e-27 88.3 In-house 9-158 (162) alignment 
Range on Protein: 3-144
Range on HMM: 9-158/162.0
NSIDKVCTGLYVGGIMGASKKELLLENNITHVLAVLDN------AEPHFPE--NFQYKCIKISDSPSCDLSVHFKESVDFIHKCRI-EGGSCYVHCAAGI
...| |  .||||.   |..|. | .  |||||   .       ....| .  ...|  ....|.|..|||..|.....||..    . |  .|||..|.
kevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGv

SRSVTLCTVYLMTATTLSYEDAMTVmVYARSMAGPNFGFRMQMMKYTKTIL
||| ||   |||    ..  .|..  | .. . .|| ||  |.... . . 
sRsatlvlayLmirrkmtlveairt.vrkkReilPneGFlkqLaeldeelk
0046846 (Phosphotyrosine protein) phosphatases II 3-143 4.2e-26 87.2 In-house 10-172 (176) alignment 
Range on Protein: 3-143
Range on HMM: 10-172/176.0
NSIDKVCTGLYVGGIM----------GASKKELLLENNITHVLAVLDNAEPHF-----------PENFQYKCIKISDSPSCDLsVHFKESVDFIHKCRIE
...| .  .|..|.             |.  |.|.|..||.|. ...  | ..            ...||... . |   .||  .. | ..||.... |
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

GGSCYVHCAAGISRSVTLCTVYLMTA-TTLSYEDAMTVMVYARS-MAGPNFGFRMQMMKYTKTI
||  .||| |||.|. ||.  ||.     ||.|.|.  .   |. .| ...... . ... . .
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0049772 (Phosphotyrosine protein) phosphatases II 42-142 2.6e-25 85.2 In-house 173-272 (314) alignment 
Range on Protein: 42-142
Range on HMM: 173-272/314.0
EPHFPEN-FQYKCIKISDsPSCDLSVHFKESVDFIHKCrIEGGSCYVHCAAGISRSVT-LCTVYLMTATTLSYEDAMTVMVYARSmAGPNFGFRMQMMKY
 ..|... ..|..| ..| .|..|. .|.| ..||...  .||  .|||.||..|. | ... ||| .  .|.|.|.  .  .|. ..||.||. | . |
pelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqy

TKT
 . 
efi
PTEN_1 8-145 2.7e-25 84.4 In-house 44-193 (196) alignment 
Range on Protein: 8-145
Range on HMM: 44-193/196.0
VCTGLYVGGIMGA-SKKELLLENNITHVLAVLDNAEP---------HFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRI--EGGSCYVHCAAGISR
.. |||.| .  . . .. | |..||.|. . .  |          .| ....|. . | | . ..|| .|.. ..||. ..   .|. ..|||.||..|
ideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgR

SVTLCTVYLMTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTILN
|.|..  ||| .  |....|.  .  .|. ..|| ... . ..| . .|.
sGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
subfamily_DSP8_pd Subfamily DSP8 6-145 3.9e-25 82.3 In-house 16-156 (159) alignment 
Range on Protein: 6-145
Range on HMM: 16-156/159.0
DKVCTGLYVGGIMGASKKELLLENNITHVLAVL-DNAEPHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYL
 ..   ||.|    . ..||| ...|..|| .     .... .. ..  . . |. . .|.  |..||.|| |.. | |.. ||. |||||| |.   |.
trilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayi

MTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTILN
|    .|...| . .   | .  ||. |  |...| |.. .
mktlemsldeayrfvkekrptispnlnflgqLleyekelkl
0040439 (Phosphotyrosine protein) phosphatases II 9-141 4.4e-25 84.2 In-house 33-243 (249) alignment 
Range on Protein: 9-141
Range on HMM: 33-243/249.0
CTGLYVGGIMGASKKE------------------------LLLENNITHVLAVLDNAEP-----------------------------------------
. ||. ..   ||  .                        .| |..||... . .  |.                                         
lpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlelt

--HFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRI------EGGSCYVHCAAGISRSVTLCTVYLM-----TATTLSYEDAMTVMVYARSMAGPNF
   ..| .....| . | |  ... .|.. .|||...|       .|| ..||| ||..|. |... |||     .  ....|.|.  .  .|..| .|.
nlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp

GFRMQMMKYTK
.. .. ... .
eqyrflyeall
0036282 (Phosphotyrosine protein) phosphatases II 8-140 4.5e-25 83.7 In-house 15-166 (174) alignment 
Range on Protein: 8-140
Range on HMM: 15-166/174.0
VCTGLYVGGIMGAsKKELLLENNITHVLAVLDNAEPH---------------FPENFQYKCIKISDSPSCDLSVhFKESVDFIHKCRIE--GGSCYVHCA
. ..|..|.   |   |.| |..||.|. .|.  |..                ....||... . |    |||. . | |.|..... |  || ..||| 
itprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCs

AGISRSVTLCTVYLMTATTL-SYEDAMTVMVYAR---SMAGPNFGFRMQMMKYT
||..|. ||.  |||    | |..||. ..  .|   ... ........  .. 
aGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
subfamily_STYX_pd Subfamily STYX 5-145 6.3e-24 77.9 In-house 12-159 (166) alignment 
Range on Protein: 5-145
Range on HMM: 12-159/166.0
IDKVCTGLYVGGIMGA--SKKELLLENNITHVLAVLDNAE-----PHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSV
....  ||..|    |  || | | .. |||.. . .| |     | ||..|.|  . ..|..  ..  .. .  .|| ..  .||   ||  |||||| 
mqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

TLCTVYLMTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTILN
.|   |.| .  | | .|.. .   |    || ||  |...|    | 
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyla
subfamily_MKPLT_pd Subfamily MKPLT 11-144 1.2e-23 77.4 In-house 28-161 (164) alignment 
Range on Protein: 11-144
Range on HMM: 28-161/164.0
GLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTATTL
 || |    | ....| . .|||.. |  .    ||. ..|  .|..| .   || ...   .|. .    ||  .|||  | ||| .    .|..    
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

SYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTIL
 ...|   .   ||.. || || .|. |. . ||
tlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_MKPLV_pd Subfamily MKPLV 11-144 1.2e-23 77.4 In-house 28-161 (164) alignment 
Range on Protein: 11-144
Range on HMM: 28-161/164.0
GLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTATTL
 || |    | ....| . .|||.. |  .    ||. ..|  .|..| .   || ...   .|. .    ||  .|||  | ||| .    .|..    
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

SYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTIL
 ...|   .   ||.. || || .|. |. . ||
tlkeayeylkerrsivapnrGflkqlakfeelil
0045450 (Phosphotyrosine protein) phosphatases II 24-141 4.1e-23 78.0 In-house 125-301 (307) alignment 
Range on Protein: 24-141
Range on HMM: 125-301/307.0
ELLLENNITHVLAVLDNAEP-----------------------------HfPENFQYKCIKISDS-----------------PSCDLSVHFKESVDFIHK
..| |...|... . .  |                              |  ..... .....|.                 |  ... .|.| .|||..
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

CRI------EGGSCYVHCAAGISRSVTLCTVYLMTATT--------LSYEDAMTVMVYARSMAGPNFGFRMQMMKYTK
.|       .|| ..||| ||..|. |... |||            .....|.  .   |. | .|... .. ... .
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 11-141 1e-22 76.4 In-house 45-239 (243) alignment 
Range on Protein: 11-141
Range on HMM: 45-239/243.0
GLYVGGI--------MGASKKELLLENNITHVLAVLDNA---------------------------------------------EPHFPENFQYKCIKIS
.|....         . ||  ..| |..||... . .                                               .... ....| .. . 
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

D----SPSCDLSVHFKESVDFIHK-----CRIEGGSCYVHCAAGISRSVTLCTVYLMTAT-TLSYEDAMTVMVYARSM-AGPNFGFRMQMMKYTK
|    .   ||  ...|  .||..     .. .|| ..||| ||..|. ||.. |||    ....|.|.  .   |.. | ........ ... .
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall
0042113 (Phosphotyrosine protein) phosphatases II 7-142 1.2e-22 75.9 In-house 49-241 (245) alignment 
Range on Protein: 7-142
Range on HMM: 49-241/245.0
KVCTGLYVGGIMGASKKE----LLLENNITHVLAVLDNAE----------------------------------------------PHFPENFQYKCIKI
... ......   ..  |    .| |..||... . .  |                                              .   |...| .. .
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

SDSPSCDLSVHFKESVDFIHKCRI--EGGSCYVHCAAGISRSVTLCTVYLM-----TATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKT
 | . .||. .. . ..|..|..   ..| ..||| ||..|. |....|||     .  ..| |.|.  .   |..| ..... ...... . 
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 12-143 8.3e-22 70.9 In-house 6-141 (145) alignment 
Range on Protein: 12-143
Range on HMM: 6-141/145.0
LYVGGIMGASKKELLLENNITHVLAVL----DNAEPHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTA
|||| .. |..  .| |  |. .. .       ..    |...   |  .|  | ||| || |  ||| | . ||   .||| ||.|||||.   .||  
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

TTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTI
 ...  .|   .   | .| ||  |  ....  | .
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0040438 (Phosphotyrosine protein) phosphatases II 25-144 2.1e-21 72.0 In-house 105-276 (317) alignment 
Range on Protein: 25-144
Range on HMM: 105-276/317.0
LLLENNITHVLAVLDNAEPH---------------------------FPENFQYKCIKISDS----------------PSCDLSVHFKESVDFIHKCRIE
.. |...|... . .  |.                              ..... .....|.                |  ..  .... .||....|  
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----GGSCYVHCAAGISRSVTLCTVYLM-----TATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTIL
    || . ||| ||..|. |....|||     .  ....|.|.  .  .|..| ..... ......   .|
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 6-144 6.1e-21 68.4 In-house 4-153 (154) alignment 
Range on Protein: 6-144
Range on HMM: 4-153/154.0
DKVCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPEN---------FQYKCIKISDSPSCDLSVHFKESVDFIHKCR--IEGGSCYVHCAAGIS
.|... ||..    |  | .| ..||...| |    .  |...         ..|  ... | .  |.  ... . .||..    .| .   ||. .|.|
skeaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvs

RSVTLCTVYLMTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTIL
|| .|   |||    .|.  |. ..  .| .  || ||  |. .. |  |
rsaallisylmdklkislslalellkdsryiikPnqGflkqleifekell
0051082 (Phosphotyrosine protein) phosphatases II 8-139 4.9e-20 67.1 In-house 11-149 (151) alignment 
Range on Protein: 8-139
Range on HMM: 11-149/151.0
VCTGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPE------NFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIE-GGSCYVHCAAGISRSVTLC
|  |||..|   |   ||| |..|.... . .  |. .        ......| | | |  .|...|.. ..|.....   .| ..||| ||..|. ||.
vtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

TVYLMTaTTLSYEDAMTVMVYARS-MAGPNFGFRMQMMKY
 .|||    .|.|.|.  .   |  .  || .|..|.. .
alylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0039614 (Phosphotyrosine protein) phosphatases II 24-142 7.6e-20 67.0 In-house 119-287 (297) alignment 
Range on Protein: 24-142
Range on HMM: 119-287/297.0
ELLLENNITHVLAVLDNAEPHF------------------------------------------PENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRI-
... |...|... . .  |                                              .  .. .... |   .... .. | ........  
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--EGGSCYVHCAAGISRSVTLCTVYLM-----TATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKT
  .|| ..||| ||..|. |... |||     .  ......|.  .  .|..| ..... .. ... . 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 12-140 1e-18 61.3 In-house 15-144 (148) alignment 
Range on Protein: 12-140
Range on HMM: 15-144/148.0
LYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPEN-FQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTATTL
|..|    |.. | | . ..|..     . .  . .   .|  ....| |  |||  |.. ..|..| . ||. . ||.  |.|||  |  ..|.     
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

SYEDAMTVMVYARSMAGPNFGFRMQMMKYT
| ..|. ..  .| .  || ||  |. .. 
slkealalvkskrryvdpnlgfLkqLaele
0036941 (Phosphotyrosine protein) phosphatases II 25-142 6.9e-18 60.4 In-house 97-275 (297) alignment 
Range on Protein: 25-142
Range on HMM: 97-275/297.0
LLLENNITHVLAVLDNAEPHF-------------------------------PENFQYKCIKI----------------SDSPSCDLSVHFKESVDFIHK
...|.|.|... . .  |  .                                ... .  ...                 . |  ..  .... .|||..
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfiel

CRI------EGGSCYVHCAAGISRSVTLCTVYLM--------TATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKT
.|       .||  .||| ||..|| |.....||        .  .... .|.  .   | .| ..... ...  .   
vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
0038934 (Phosphotyrosine protein) phosphatases II 41-146 4.2e-17 57.9 In-house 72-179 (194) alignment 
Range on Protein: 41-146
Range on HMM: 72-179/194.0
AEPHFPENFQYKCIKISD---SPSCDLSVHFKESVDFIHKcRIEGGSCYVHCAAGISRSVTLCTVYLMTATTLSYEDAMTVMVYARSMAGPNFGFRMQMM
.|     ...|  . . |   .|| ..  .| . ||.... . .|| ..||| ||..|. ||.  ||.    .|.|.|.  .  .|  | || ..  ...
peefekagieylklpfpddgtvPsleillrfldlvdefln.edpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleall

KYTKTILND
|. |.. ..
krykelrka
0051429 (Phosphotyrosine protein) phosphatases II 12-143 4.7e-17 58.0 In-house 24-224 (272) alignment 
Range on Protein: 12-143
Range on HMM: 24-224/272.0
LYVGGIM---GASKKELLLENNITHVLAVLDNAEPHFP------ENFQYKCIKISDSPSCDLSVHF----------------------------------
|| .| .    |   . | |..|.... . .  |  .       ....| .. | |.   . ....                                  
lyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevm

--------------KESVDFIHKCRIeGGSCYVHCAAGISRSVTLCTVYLMTaTTLS--------------YEDAMTVMVYARSMAGPNFGFRMQMMKYT
              .. ..... ..  || ..|||.||..|. |.. ..|.    .|              .|.|.  .  .|  |... ..... ... 
hlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal

KTI
. .
lel
subfamily_STYXL1_pd Subfamily STYXL1 10-146 5.1e-16 52.3 In-house 17-156 (157) alignment 
Range on Protein: 10-146
Range on HMM: 17-156/157.0
TGLYVGGIMGASKKELLLENNITHVLAVLDNAEPHFPE---NFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMT
. ||.|    | ....  .  .  .. |  .|.. .       .   |...|..  ||  ..|| |.||.| . ||    |    |||||...   ||| 
gklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmy

ATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTKTILND
   .....|.. .   ..   || .|  |. .. |..|..
skkitlkkaykylkkCkenvkPnrafveqlseWekqllge
0043336 (Phosphotyrosine protein) phosphatases II 25-139 5.9e-16 54.2 In-house 107-272 (278) alignment 
Range on Protein: 25-139
Range on HMM: 107-272/278.0
LLLENNITHVLAVL-----------------------------------------------DNAEPHFPENFQYKCIKisDSPSC-DLSVHFKESVDFIH
.. |...|... .                                                 . |...   ..|...   |   . .|| ...   ....
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavre

KCRIEGGSCYVHCAAGISRSVTLCTVYLM-----TATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKY
... ..|  .||| ||..|. |....||.     .  ....|.|.  .   | .| ... . ..  ..
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_PTPMT1_pd Subfamily PTPMT1 22-126 2.6e-15 51.3 In-house 38-151 (171) alignment 
Range on Protein: 22-126
Range on HMM: 38-151/171.0
KKELLLENNITHVLAVLDNAE----PHFPENFQYKCIKISDSPSCDLS-----VHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTATTLSY
.|||. ..|.  |... .. |        |...   ...   .  |        . ...|.||.| . .| . |||| || .|| || . |||. . || 
ikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklsp

EDAMTVMVYARSMA
|.|....   |.. 
eeAlkalkkkRkii
0047943 (Phosphotyrosine protein) phosphatases II 23-138 1e-14 50.1 In-house 143-266 (273) alignment 
Range on Protein: 23-138
Range on HMM: 143-266/273.0
KELLLENNITHVLAVLD--NAEPHFPENFQYKCIKISDSP-SCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLM-----TATTLSYED
.|   .. ....| . .  . |...   |.|. .   . | | .  ..| | |. ...  ...|  .||| ||..|. |.....|.     .  ......
seetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvle

AMTVMVYARSMAGPNFGFRMQMMK
|.  .   | .. ... .......
avkllrsqRpgmvqtpeqyrflye
0050432 (Phosphotyrosine protein) phosphatases II 23-130 2.5e-13 45.5 In-house 174-285 (308) alignment 
Range on Protein: 23-130
Range on HMM: 174-285/308.0
KELLLENNITHVLAVLDNAEPHFPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRiEGGSCYVHCAAGISRSVTLCTVYLM-----TATTLSYEDAMT
.|  |.. .. .| . .. ..   .  .. ..   |   ..   .. . .....|.. .|| ..||| ||..|. |.....|.     .  ......|. 
seevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavk

VMVYARSMAGPNF
 .   | .. ...
klReqRpgmvqtp
0051299 (Phosphotyrosine protein) phosphatases II 24-130 1.1e-12 43.4 In-house 156-272 (288) alignment 
Range on Protein: 24-130
Range on HMM: 156-272/288.0
ELLLENNITHVLAVLDN----AEPHFPENFQYKCIKISDSPSCDlsvHFKESVDFIHKCRI----EGGSCYVHCAAGISRSVTLCTVYLM-----TATTL
|  |.. ....| | ..     .    .  .. .... |    |   .... .||....|      || ..||| ||..|. |.....|.     .  ..
eevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd...spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggv

SYEDAMTVMVYARSMAGPNF
....|.  .   | .. ...
dvleavkrlreqRpgmvqtp
0046845 (Phosphotyrosine protein) phosphatases II 22-126 3e-12 42.0 In-house 140-256 (284) alignment 
Range on Protein: 22-126
Range on HMM: 140-256/284.0
KKELLLENNITHVLAVLD---NAEPHFPENFQYKCIKISDSP-SCDLSVHFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTAT--------T
..|   .. ....| . .   . |...   |.|. .   . | | .  ..| . |. ... .  ||   ||| ||..|. |.....|.           .
lseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllg

LSYEDAMTVMVYARSMA
.....|.  .   | ..
vdvleavkrlreqRpgm
subfamily_MSG5_pd Subfamily MSG5 67-145 7.9e-11 35.3 In-house 84-161 (165) alignment 
Range on Protein: 67-145
Range on HMM: 84-161/165.0
HFKESVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTATTLSYEDAMTVMVYARSMAGPNFGFRMQMMKYTkTILN
 . .    ||  . ..    |||  |.||| .|   |.|   .|| .||   .        |..|. .|.|..  ..|.
dlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewe.vals
0048567 (Phosphotyrosine protein) phosphatases II 72-134 1.7e-08 29.0 In-house 64-131 (157) alignment 
Range on Protein: 72-134
Range on HMM: 64-131/157.0
VDFIHKCRIEGGSCYVHCAAGI---SRSVTLCTVYLMTATTLSYEDAMTVMVYAR--SMAGPNFGFRM
 .|.. .. .|.  .||| ||    .|..||.  ||.    .. |.|.  . ..|  |. ..  ..  
nkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyll
PTPc_DSPc_SM00012 63-121 3.6e-08 28.9 In-house 14-78 (105) alignment 
Range on Protein: 63-121
Range on HMM: 14-78/105.0
DLSVHFKESVDFIHKCRIE------GGSCYVHCAAGISRSVTLCTVYLMTATTLSYEDAMTVMVY
 .  . .. ........ .      .... ||| ||..|. |.......     . .. . .  .
gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqi
Y_phosphatase Protein-tyrosine phosphatase 47-120 4e-07 25.1 Pfam-A 136-207 (235) alignment 
Range on Protein: 47-120
Range on HMM: 136-207/235.0
ENFQYKCIKISDSPSCdlsvhFKESVDFIHKCRIEG----GSCYVHCAAGISRSVTLCTVYLMTATTLSyEDAMTVMV
. ..|.  . .. |..      |. .|.|.|.. .     |.. ||| ||..|. |.... ..     . |. . |. 
kqlhytnWpdhgvpes.....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea.eeevdvlq
Y_phosphatase Protein-tyrosine phosphatase 47-120 4e-07 25.1 In-house 136-207 (235) alignment 
Range on Protein: 47-120
Range on HMM: 136-207/235.0
ENFQYKCIKISDSPSCdlsvhFKESVDFIHKCRIEG----GSCYVHCAAGISRSVTLCTVYLMTATTLSyEDAMTVMV
. ..|.  . .. |..      |. .|.|.|.. .     |.. ||| ||..|. |.... ..     . |. . |. 
kqlhytnWpdhgvpes.....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea.eeevdvlq
subfamily_DSP23_pd Subfamily DSP23 22-119 1.1e-06 23.3 In-house 23-121 (148) alignment 
Range on Protein: 22-119
Range on HMM: 23-121/148.0
KKELLLENNITHVLAVLDNAEPHFP--ENFQYKCIKISDS--PSCDLSVHFkesVDFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTATTLSYEDAMT
. . ||.. . ..... ....||     |  .. ..| |   |. .  |.|   |  ...    . .  |||. |  |. |. . ||.    |.  .|..
qyrylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqvvef...vrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaia

VM
 .
ev
DSPc_SM00195 42-114 1.6e-06 23.0 In-house 154-227 (263) alignment 
Range on Protein: 42-114
Range on HMM: 154-227/263.0
EphfPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIE----GGSCYVHCAAGISRSVTLCTVYLMTATTLSYED
.    |... . ... . |  ..  . |. ........ .     | . ||| ||..|. |..|. ..     ....
k...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk
PTPc_SM00194 42-114 1.6e-06 23.0 In-house 154-227 (263) alignment 
Range on Protein: 42-114
Range on HMM: 154-227/263.0
EphfPENFQYKCIKISDSPSCDLSVHFKESVDFIHKCRIE----GGSCYVHCAAGISRSVTLCTVYLMTATTLSYED
.    |... . ... . |  ..  . |. ........ .     | . ||| ||..|. |..|. ..     ....
k...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk
subfamily_CDC14_pd Subfamily CDC14 57-123 2.4e-06 21.7 In-house 237-304 (328) alignment 
Range on Protein: 57-123
Range on HMM: 237-304/328.0
SDSPSCDLSVHFKESVD-FIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTATTLSYEDAMTVMVYAR
.|    | |.  .. |  |.. .    |.  ||| ||. |  || ..|||    .. ..|.. .  .|
kDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricr
subfamily_DSP11_pd Subfamily DSP11 60-142 6e-06 20.3 In-house 93-169 (178) alignment 
Range on Protein: 60-142
Range on HMM: 93-169/178.0
PSCDLSVHFKESV-DFIHKCRIEGGSCYVHCAAGISRSVTLCTVYLMTATTLSYEDAMTVMVYARsmagpnfGFRMQMMKYTKT
|. .|  .||| | .|..|.  ..    |||. |. |.  |   ||.  . .. |||. .. .||       |. ..  .| | 
pkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear.......Ghslerenylkd