Gene PRL in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP012_AA protein Get Run
AqueP012_AA_20-165 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PRL_pd Subfamily PRL 20-166 1.5e-74 243.0 In-house 2-148 (151) alignment 
Range on Protein: 20-166
Range on HMM: 2-148/151.0
PSLIEYKQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSYSSEPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTFEKSPNCSLAVHCVAGL
.. ||||...|||...||.|||..||.||.|...| |||.|||.|..|.|...||.|.||.||||..|||.....|| ..|..|...|....||||||||
eveieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGl

GRAPVLVAIALIEKGMKYHEAVDFIRNKRRGAINKRQLDFLENYKSK
||||||||.||||.||||..||.|||.|||||||..||.|||.||.|
GraPvlvalalieaGmkyedavefirekrrgainskqlkflekykak
0038934 (Phosphotyrosine protein) phosphatases II 28-163 2.1e-33 111.0 In-house 18-169 (194) alignment 
Range on Protein: 28-163
Range on HMM: 18-169/194.0
QKFLIINNPTSATLPNFINELEKNQAKIVVRCC----------------EPSYSSEPLKAKGIDVIDLQFDD-GGSPPEDIIRQWLVIVKDTFEKSPNCS
 .|.... |.| .| ..|.|| ..  . .||..                |. |. | ... ||....|.| | | .|. .|....| .|.. ....|.. 
grfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggv

LAVHCVAGLGRAPVLVAIALIE-KGMKYHEAVDFIRNKRRGAInkRQLDFLENY
 ||||.|||||...||| .||.  ||...||....| ||.|||  .. |.|| .
vaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai..pnqdyleal
0043147 (Phosphotyrosine protein) phosphatases II 25-163 2e-32 107.7 In-house 17-156 (172) alignment 
Range on Protein: 25-163
Range on HMM: 17-156/172.0
YKQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSYSSEPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTFEKSPNCSLAVHCVAGLGRAPV
|. ..|..   |.. ||. |.. | ... ...|...|  |  |.|.  || .. | ..|.| |. ......| .... . .||..  .|||.||.||...
yipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgt

LVAIALIEKGMKYHEAVDFIRNKRRGAI-NKRQLDFLENY
|||. |...|....|||...|.||.||. |. |. ||  .
lvaaylmllglsleeavalvrekRpgavqnpsqyrflyyf
0049260 (Phosphotyrosine protein) phosphatases II 27-163 8.9e-32 105.3 In-house 8-145 (152) alignment 
Range on Protein: 27-163
Range on HMM: 8-145/152.0
QQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSYSSEPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTFEKSPNCSLAVHCVAGLGRAPVLV
...|..   |.. ||..|.. | .......|...|...  ..  ...| .. |...|.| |. ... ..|... . . .....  .|||.||.||...||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

AIALIEKGMKYHEAVDFIRNKRRGAI-NKRQLDFLENY
|. |...|... |||...|.|| ||. |. || || ..
aaylmllgvsleeavalvrekRpgavpnpgqlrflyef
0045098 (Phosphotyrosine protein) phosphatases II 21-163 1e-26 89.4 In-house 57-267 (278) alignment 
Range on Protein: 21-163
Range on HMM: 57-267/278.0
SLIEYKQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSYSS----------------------------------------------EPLKAKGI
|.|.. ..||..   |.  |. .|.. | ... ...|...|  . .                                              | |.  |.
syidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgv

DVIDL-QFDDGGSPPEDIIRQWLVIVKDTFEKS---------------PNCSLAVHCVAGLGRAPVLVAIALIEK----GMKYHEAVDFIRNKRRG-AI-
 ....  ..|.|.|...|....| ...   |                 ...  .||| ||.||. .|||. |. .    |. . |||...|..|.| |. 
thlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavq

NKRQLDFLENY
|. |. ||. .
nleqyrflyef
0040439 (Phosphotyrosine protein) phosphatases II 25-163 2.3e-26 88.3 In-house 51-241 (249) alignment 
Range on Protein: 25-163
Range on HMM: 51-241/249.0
YKQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPS---------------------------------------------YSSEPLKAKGIDVIDL
| ...|..   |.. |...|.. | ... ...|.....                                              | .|... ..| ..|.
yikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdw

QfDDGGSPPEDIIRQWLVIVKDTFEKS-PNCSLAVHCVAGLGRAPVLVAIALI------EKGMKYHEAVDFIRNKRRGAI-NKRQLDFLENY
  |.| .|  ... ... .|.. .|.  ... ..||| ||.||.....|. |.      |.|. . |||...|..|.||. |  |. || ..
p.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0046846 (Phosphotyrosine protein) phosphatases II 29-163 3.1e-26 87.6 In-house 24-168 (176) alignment 
Range on Protein: 29-163
Range on HMM: 24-168/176.0
KFLIINNPTSATLPNFINELEKNQAKIVVRCCEP--------SYSSEPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTFEKSpnCSLAVHCVAGLG
....   |.  ||..|. .| ... ..||...|.         .  . |.. || .. | ..|.| |. ... ..| ....  ..      .|||.||.|
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGig

RAPVLVAIALIEK--GMKYHEAVDFIRNKRR-GAI-NKRQLDFLENY
|...|||. |.|.  |....||....|..|. ||. .  |. ||. .
RtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyef
0041856 (Phosphotyrosine protein) phosphatases II 25-164 7e-26 86.3 In-house 31-166 (182) alignment 
Range on Protein: 25-164
Range on HMM: 31-166/182.0
YKQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSYSSEPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDtfeksPNCSLAVHCVAGLGRAPV
.....|.. . |.  |...|.. | ... ...|...|. |  | |.  || ...|...|.| |. |.. ... .|..     ...  .||| ||.||...
lpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eggpvlVHCsaGvgRtgt

LVAIALIE-KGMKYHEAVDFIRNKRRGAINKRQLDFLENYK
|||. |.. .|. . |||...|..| |..   .  |.. ..
lvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqla
0042113 (Phosphotyrosine protein) phosphatases II 27-163 1.1e-25 85.9 In-house 51-238 (245) alignment 
Range on Protein: 27-163
Range on HMM: 51-238/245.0
QQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSYS-------------------------------------------SEPLKAKGIDVIDLQFDD
 .||.. . |.. |...|.. | ... ...|...|. .                                             .. . ..| .  | ..|
tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpd

GGSPP-EDIIRQWLVIVKDTFEKSPNCSLAVHCVAGLGRAPVLVAIALI------EKGMKYHEAVDFIRNKRRGAI-NKRQLDFLENY
.| |.  ... ..| .|..  ....|  ..||| ||.||. ...|. |.      |.|.   |||...|..|.||. .  |. ||  .
hgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0036282 (Phosphotyrosine protein) phosphatases II 27-164 2.2e-25 84.8 In-house 16-166 (174) alignment 
Range on Protein: 27-164
Range on HMM: 16-166/174.0
QQKFLIINNPTSatlpnFINELEKNQAKIVVRCCEPSYSS------------EPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTFEKSPNCSLAVH
  .... . |..     |. .| ... ..||...|. .              | |.  || ...| ..|.| |. .|..... .|.. ....|.. ..||
tprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVH

CVAGLGRAPVLVAIALIEKGM--KYHEAVDFIRNKR----RGAINKRQLDFLENYK
| ||.||...|||. |...|.  .. .|.|..| .|    .. ..  |. ||  ..
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
0045450 (Phosphotyrosine protein) phosphatases II 25-163 2.6e-25 85.2 In-house 104-299 (307) alignment 
Range on Protein: 25-163
Range on HMM: 104-299/307.0
YKQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSYSSEP------------------------------------------LKAKGIDVIDLQF-
....||..  .|.. |. .|.. | ... ...|...|. .   .                                           . ... |. ... 
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

--DDGGSPP-EDIIRQWLVIVKDTFEKS-PNCSLAVHCVAGLGRAPVLVAIALIEKG---------MKYHEAVDFIRNKRRGAI-NKRQLDFLENY
   |.| ||  ... ... .|.. .|.. ...  .||| ||.||.....|. |. ..         . . |||...|..| ||. |  |. || ..
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0037934 (Phosphotyrosine protein) phosphatases II 28-163 9.2e-24 79.8 In-house 44-237 (243) alignment 
Range on Protein: 28-163
Range on HMM: 44-237/243.0
QKFLIINNPTSATLPN----FINELEKNQAKIVVRCCEPS------------------------------------------YSSEPLKAKGIDVIDLQF
 .. . . |.. |. .    |.. | ... ...| ..|.                                           .. ..|.  .| .  | .
prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpw

DDGGSPP-EDIIRQWLVIVKDTFEK-------SPNCSLAVHCVAGLGRAPVLVAIALIEK--GMKYHEAVDFIRNKRRG-AI-NKRQLDFLENY
 |.| |.  ... ..| .|..  |.       ...  ..|||.||.||. .|.|. |. .  |. . |||...|..| | |. .  |. ||  .
pdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0039614 (Phosphotyrosine protein) phosphatases II 27-163 1.8e-23 78.9 In-house 100-284 (297) alignment 
Range on Protein: 27-163
Range on HMM: 100-284/297.0
QQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSYS----------------------SEPLKAKGIDVIDL-----------------QFDDGGSP
..||..   |.. |. .|.. . ... ...|. ... .                        .  . .|. |  |                  . |.| |
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvp

P-EDIIRQWLVIVKDTFEKS-PNCSLAVHCVAGLGRAPVLVAIALI------EKGMKYHEAVDFIRNKRRGAI-NKRQLDFLENY
|  ... ..| .|.. .... ...  .|||.||.||. ...|. |.      |.|. . |||...|..|.||. .  |. || ..
pslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0043336 (Phosphotyrosine protein) phosphatases II 27-160 2.3e-23 78.5 In-house 87-269 (278) alignment 
Range on Protein: 27-160
Range on HMM: 87-269/278.0
QQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPS--------------------------------------------YSSEPLKAKGIDVIDLQfd
..||..   |.. |. .|.. . ... ...|. .|.                                             ...|...  ..  ..    
prkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..

DGGSP-PEDIIRQWLVIVKDTFEkSPNCSLAVHCVAGLGRAPVLVAIALI------EKGMKYHEAVDFIRNKRRGAI-NKRQLDFL
|.| | . ... ..| .|.. .| ..|  ..|||.||.||. ...|. |.      |.|. ..|||...|..| ||. .  |. ||
dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl
0044763 (Phosphotyrosine protein) phosphatases II 38-164 3e-23 77.8 In-house 34-167 (178) alignment 
Range on Protein: 38-164
Range on HMM: 34-167/178.0
SATLPNFINELEKNQAKIVVRCCEPSY------SSEPLKAKGIDVIDLQFDDGGSPP-EDIIRQWLVIVKDTFEkSPNCSLAVHCVAGLGRAPVLVAIAL
|.  ..... | ..  . .|...|. .        . ..  || .. . ..|.| |.  ....... ....  . ....  .||| ||.||...|||. |
slppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaayl

I-EKGMKYHEAVDFIRNKRRGAINKRQLDFLENYK
. . |. ..||....|..|.. .|  || .|. . 
mkklglsleeaielvrerRpivpnpgqlrqLyefe
0040438 (Phosphotyrosine protein) phosphatases II 26-163 4.7e-23 77.4 In-house 84-271 (317) alignment 
Range on Protein: 26-163
Range on HMM: 84-271/317.0
KQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSYS------------------------SEPLKAKGIDVIDLQF-------------------D
...||..   |.. |. .|.. . ... ...|. .|. .                          .  . .|| .  |..                   .
lkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp

DGGSPP-EDIIRQWLVIVKDTFEkSPNCSLAVHCVAGLGRAPVLVAIALI------EKGMKYHEAVDFIRNKRRGAI-NKRQLDFLENY
|.| ||  |.. ..| .|.. .| .|.. ..|||.||.||. ...|. |.      |.|. . |||...|..|.||. .  |. ||  .
dhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0051082 (Phosphotyrosine protein) phosphatases II 33-160 1.1e-22 75.7 In-house 18-144 (151) alignment 
Range on Protein: 33-160
Range on HMM: 18-144/151.0
INNPtsatLPNFINELEKNQAKIVVRCCEPS---YSSEPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTFEKSPNCSLAVHCVAGLGRAPVLVAIA
 . |    |. |...|.... | .| ....    |  |.|.. ||.|......|   |. ... .... . . ... .|  ..||| ||.||  .|||. 
sggp....ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvaly

LIEKGMKYHEAVDFIRNKRRGAINKRQLDFL
|.  |. . ||....| || |...  |  ..
lmllgvsleealeeyrlkrpgvvqpnqqflf
0049772 (Phosphotyrosine protein) phosphatases II 23-164 2e-22 75.8 In-house 83-270 (314) alignment 
Range on Protein: 23-164
Range on HMM: 83-270/314.0
IeykqQKFLIINNPTSATLPNF------------------------------------------------------------------Ineleknqakiv
.    .||..  .|.. |. .|                                                                              
f....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...........

vrccEPSYSSEPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTfekSPNCSLAVHCVAGLGRAP--VLVAIALIEKGMKYHEAVDFIRNKRRGAINK
    |  |. | ..  || .... ..||. |........| ....    ...  ..||| || ||..  |..|. ..  |. ..||....|.||   .|.
....eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnp

RQLDFLENYK
... .||.| 
gfieqleqye
0048179 (Phosphotyrosine protein) phosphatases II 45-164 1.3e-20 69.1 In-house 22-141 (144) alignment 
Range on Protein: 45-164
Range on HMM: 22-141/144.0
INELEKNQAKIVVRCCEPsYSSEPLKAKGIDVIDLQFDDGGSPPE-DIIRQWLVIVKDTFEksPNCSLAVHCVAGLGRAPVLVAIALI-EKGMKYHEAVD
. .| |.. . |....|. |  | |.  || .. | ..| | |.  ......| ....  |  ...  .||| ||.||...|||. |. ..|. ..||..
lellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsleeala

FIRNKRRGAI-NKRQLDFLENYK
..|..| ||. |  || ||..| 
lvrsrrpgavpnpgqlrfLleye
subfamily_CDC14_pd Subfamily CDC14 43-164 2.1e-20 67.9 In-house 203-320 (328) alignment 
Range on Protein: 43-164
Range on HMM: 203-320/328.0
NFINELEKNQAKIVVRCCEPSYSSEPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTfekspNCSLAVHCVAGLGRAPVLVAIALIEK-GMKYHEAV
....   ||. . |||  .  |  .  ...|.|  || | ||. |.. |....| |....     . ..|||| |||||.  |.|  |... ..   ||.
klleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaeai

DFIRNKRRGAINKRQLDFLENYK
 ..|  | | .   |  |||. .
awlricrPGsvigpqqkfleekq
0050432 (Phosphotyrosine protein) phosphatases II 25-155 2.4e-20 68.5 In-house 105-285 (308) alignment 
Range on Protein: 25-155
Range on HMM: 105-285/308.0
YKQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSYSS--------------EPLKAKGIDV---------------IDLQF--------------
....||..   |.. |. .|.  . ... ...|. ... . .              ..|. ... |               . |..              
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhy

---DDGGSPP-EDIIRQWLVIVKDTFeksPNCSLAVHCVAGLGRAPVLVAIALI------EKGMKYHEAVDFIRNKRRGAINKR
    |.| ||  .|. ..| .|....   |..  .||| ||.||. ...|. |.      |.|. . ||| ..| .| |...  
tnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
PTEN_1 41-165 3.5e-20 67.7 In-house 56-189 (196) alignment 
Range on Protein: 41-165
Range on HMM: 56-189/196.0
LPNFINELEKNQAKIVVRCCE------PSYSSEPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTFEKSP-NCSLAVHCVAGLGRAPVLVAIALIEK
.... ..|... .  ||. .|      .||. |  ...|. .... ..| | |. . .  ... ...   . | .   .||| |||||  ..||  |..|
vaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmyk

G-MKYHEAVDFIRNKR-RGAINKRQLDFLENYKS
| . ..||....| || .||.| ...  |..| .
gkltadeAlelvrekRppgapnspsqerlleyfa
0047943 (Phosphotyrosine protein) phosphatases II 25-156 4.1e-20 67.8 In-house 74-260 (273) alignment 
Range on Protein: 25-156
Range on HMM: 74-260/273.0
YKQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSYSSE--------------PLKAKGIDV--------------------------------ID
....||..  .|.. |. .|.. . .......|. .|. . .               .|. . . |                                  
nlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhy

LQFDDGGSP-PEDIIRQWLVIVKDTFEKS-PNCSLAVHCVAGLGRAPVLVAIALI------EKGMKYHEAVDFIRNKRRGAIN-KRQ
. . | | |   ... ... .|....|..  |   .|||.||.||. ...|. |.      |.|. . ||| ..|..| |..    |
tgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq
0051299 (Phosphotyrosine protein) phosphatases II 26-154 4.6e-19 64.4 In-house 90-271 (288) alignment 
Range on Protein: 26-154
Range on HMM: 90-271/288.0
KQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPS-------------------------------------------------YSSEPLKAKGIDV
...||..   |.. |. .| . . ... ...|. ...                                                  ...|... . . .
lkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhy

IDLQfdDGGSPP-EDIIRQWLVIVKDTFEkSPNCSLAVHCVAGLGRAPVLVAIALI------EKGMKYHEAVDFIRNKRRGAINK
..    | | |.  . . ..| .|.. .. |...  .||| ||.||. ...|. |.      |.|. . ||| ..|..| |... 
tnwp..dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
0048076 (Phosphotyrosine protein) phosphatases II 45-163 6e-19 63.6 In-house 22-138 (145) alignment 
Range on Protein: 45-163
Range on HMM: 22-138/145.0
INELEKNQAKIVVRCcepSYSSEPLKAKGIDVIDLQFDDGGSPPE-DIIRQWLVIVKDTFEKspNCSLAVHCVAGLGRAPVLVAIALIEK-GMKYHEAVD
. .|.... . |...   ..  | |...|| .. | ..| | |.  ......| ....  ..  ..  .||| ||.||...|||. |. . |. ..||..
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmlllgvsleeale

FIRNKRRGAI-NKRQLDFLENY
..|..|.||. |  || ||. .
lvrsqrpgavpnpgqlrflyef
0046845 (Phosphotyrosine protein) phosphatases II 25-154 1.9e-18 62.3 In-house 74-259 (284) alignment 
Range on Protein: 25-154
Range on HMM: 74-259/284.0
YKQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSY-----------------------------------------------SSEPLKAKGIDVI
|...||..   |.. |. .| . . .......|  .|.                                                 ..|... . . ..
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhyt

DLQfdDGGSPP-EDIIRQWLVIVKDTFEK-SPNCSLAVHCVAGLGRAPVLVAIALIEK---------GMKYHEAVDFIRNKRRGAINK
.    | | ||  ... ..| .|.. .|. ....  .||| ||.||. ...|. |. .         |. . ||| ..|..| |... 
swp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
0036941 (Phosphotyrosine protein) phosphatases II 25-153 2.5e-16 55.3 In-house 75-261 (297) alignment 
Range on Protein: 25-153
Range on HMM: 75-261/297.0
YKQQKFLIINNPTSATLPNFINELEKNQAKIVVRCCEPSY------------------SSEPLKAKGIDVID----------------------------
. ..||..   |.. |. .|   . ... ...|  .|.                      .... . ..|                              
dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfh

-LQFDDGGSPP-EDIIRQWLVIVKDTFEKS-PNCSLAVHCVAGLGRAPVLVAIAL---------IEKGMKYHEAVDFIRNKRRGAIN
 .  .| | |.  ... ...  |..  ... ..    |||.||.||. ...|. |         .|.|. . ||| ..|..| ||. 
ytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq
0051429 (Phosphotyrosine protein) phosphatases II 26-162 1.3e-14 50.1 In-house 20-219 (272) alignment 
Range on Protein: 26-162
Range on HMM: 20-219/272.0
KQQKFLIINNPTSATLPNFINElEKNQAKIVVRCCEPS---YSSEPLKAKGIDVIDLQFDDGGSPPE---------------------------------
|  ...  ..|. .|  .|    .... | .|  ....   .   .. . ||... | . | . |.                                  
kpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsage

-------------------DIIRQWLVIVKDtfekspNCSLAVHCVAGLGRAPVLVAIALIEKGMK--------------YHEAVDFIRNKRRGAI-NKR
                   . ....| .. |      .  . ||| || .|  ..||. |.  |.               . |||. .| .|.||. .  
arevmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqtee

QLDFLEN
|. || .
qylflye
subfamily_PTPDC1_pd Subfamily PTPDC1 63-164 6.3e-14 46.8 In-house 72-172 (182) alignment 
Range on Protein: 63-164
Range on HMM: 72-172/182.0
SYSSEPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTFEKSpncSLAVHCVAGLGRAPVLVAIALI-EKGMKYHEAVDFIRNKRRGAINKR-QLDFL
||. | |...|| |  . ..| |... . | .   .|. . ..     .|||| |||||. ||.|  |.  | .. ..|....|.||  .|. | |....
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelv

ENYK
....
kefa
0048567 (Phosphotyrosine protein) phosphatases II 67-161 5.7e-12 40.3 In-house 31-131 (157) alignment 
Range on Protein: 67-161
Range on HMM: 31-131/157.0
EPL-KAKGIDVIDLQFDDGgSPPEDIIRQWLVIVKDTFE--KSPNCSLAVHCVAGL---GRAPVLVAI-ALIEKGMKYHEAVDFIRNKRRGAINKRQLDF
 ..    |.  .|. ||.|  .. .|. .. ..... ..  .  .. .|||| |||   ||. .|..  ...  |.  .||....|  | | .  |.  .
lyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasy

LE
|.
ll
subfamily_PTEN_pd Subfamily PTEN 41-148 8.8e-11 37.1 In-house 50-156 (184) alignment 
Range on Protein: 41-148
Range on HMM: 50-156/184.0
LPNFINELEKNQAKIVVRCCEPSYSSEPLKAKgidVIDLQFDDGGSPPEDIIRQWLVIVKDTFEKSPNCSLAVHCVAGLGRAPVLVAIALIEKGMKY--H
. .|...  |.. ||   . | .|.|. .. .   |. ..|||  .|| ..... .  ... .|....   .||| || ||. ||..  |.....    .
vvkflekkhkdhykiynlrserkydskkfdgr...vavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekae

EAVDFIRNKR
||...  ..|
ealelfaeaR
subfamily_RNGTT_pd Subfamily RNGTT 59-164 1.3e-10 35.2 In-house 63-172 (189) alignment 
Range on Protein: 59-164
Range on HMM: 63-172/189.0
CCEPSYSSEPLKAKGIDVIDLQFDDGG-SPPEDIIRQWLVIVKDTFEKSPNCSLAVHCVAGLGRAPVLVAIALIEK-GMKYHEAVDFIRNKRRGAINKRQ
  .. |  | |. .||  . ||    | .| .. ....  .|.. |.|.|.. ..|||  |  |.  |..  |.||  .. ..||.  .. |   | | .
ntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyked

--LDFLENYK
   ..|. |.
ylkellrrYa
DSPc Dual specificity phosphatase, catalytic domain 51-155 6.6e-10 34.0 Pfam-A 17-120 (133) alignment 
Range on Protein: 51-155
Range on HMM: 17-120/133.0
NQAKIVVRCCEPSYSSEPLKAKGIDVIDLQFDDggsPPEDIIRQWLVIVKDTFE--KSPNCSLAVHCVAGLGRAPVLVAIALIE-KGMKYHEAVDFIRNK
.. ..|. . .    .   | . |. .... .|     |. | ..|  ...  |  .. ... .||| ||. | . |..  |.. |.... ||..|....
lgitlvinvtkevpnnnaikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvker

RrGAINKR
| ..|...
r.skispn
DSPc Dual specificity phosphatase, catalytic domain 51-155 6.6e-10 34.0 In-house 17-120 (133) alignment 
Range on Protein: 51-155
Range on HMM: 17-120/133.0
NQAKIVVRCCEPSYSSEPLKAKGIDVIDLQFDDggsPPEDIIRQWLVIVKDTFE--KSPNCSLAVHCVAGLGRAPVLVAIALIE-KGMKYHEAVDFIRNK
.. ..|. . .    .   | . |. .... .|     |. | ..|  ...  |  .. ... .||| ||. | . |..  |.. |.... ||..|....
lgitlvinvtkevpnnnaikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvker

RrGAINKR
| ..|...
r.skispn
subfamily_DSP23_pd Subfamily DSP23 72-154 9.7e-10 33.3 In-house 50-131 (148) alignment 
Range on Protein: 72-154
Range on HMM: 50-131/148.0
KGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTFEKspNCSLAVHCVAGLGRAPVLVAIALI-EKGMKYHEAVDFIRNKRRGAINK
 .. .  |. ||   |  . . ... .|... ||  | ...|||. | ||.  ..|  |. |...   ||.  .|..| |... 
pnltlvrlriddyhppaleqvvefvrvveeaeek..neavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvet
subfamily_PTPMT1_pd Subfamily PTPMT1 65-166 1.1e-09 33.0 In-house 65-167 (171) alignment 
Range on Protein: 65-166
Range on HMM: 65-167/171.0
SSEPLKAKGIDVIDLQFDDGG-SPPEDIIRQWLVIVKDTFEKSpnCSLAVHCVAGLGRAPVLVAIALI-EKGMKYHEAVDFIRNKRRG-AINKRQLDFLE
|.|  |  |.. . |.  |   .|  . . . . ..... .|    .. ||| || ||.  |||  |. .. .. .||......||.   ..|.|.. |.
steewkklgveqlqlatvDfteapdleklekgvefiekvaskg..krvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalq

NYKSK
.|..|
eyeek
PTPc_motif_SM00404 71-161 2.3e-09 32.3 In-house 44-132 (140) alignment 
Range on Protein: 71-161
Range on HMM: 44-132/140.0
AKGIDVIDLQFDD-GGSPPEDIIRQWLVIVKDTfeKSPNCSLAVHCVAGLGRAPVLVAIALI-EKGMKYHEAVDFIRNKRrgAINKRQLDFLE
 .|. .. .. || . ..  . ... | ....   .. ...  ||| ||. |   |..  |. .......||..|....|   | ...| |..
nsgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR..piispnlnfvr
PTPc_DSPc_SM00012 83-153 3e-09 32.4 In-house 12-91 (105) alignment 
Range on Protein: 83-153
Range on HMM: 12-91/105.0
DGGSPP-EDIIRQWLVIVKDTFEKSPN-CSLAVHCVAGLGRAPVLVAIALIEKGMKYHE-------AVDFIRNKRRGAIN
| | |   | | ..|  ||.  .|| .  .. ||| || ||. ..||.... . .....        |  .|..|.|...
dhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvq
subfamily_VSP_pd Subfamily VSP 32-149 6e-09 30.1 In-house 56-171 (212) alignment 
Range on Protein: 32-149
Range on HMM: 56-171/212.0
IINNPTSAtLPNFINELEKNQAKIVVRCCEPSYSSEPLKAKgidVIDLQFDDGGSPPEDIIRQWLVIVKDTFEKSPNCSLAVHCVAGLGRAPVLVAIALI
.  || |  .  |...  ... |.|  | | .|  . .. .   |. .. ||   |  . . .   .||. .|| ..  ||.||  | ||.  .|   |.
lyrnpise.varfldtkhrdhykvvnlcseraydekyfnnr...vkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalll

EKGM--KYHEAVDFIRNKRR
. ..  . .|..|.. ..| 
aseifetakesldyfgerrt
Y_phosphatase Protein-tyrosine phosphatase 97-159 7e-08 27.5 Pfam-A 157-228 (235) alignment 
Range on Protein: 97-159
Range on HMM: 157-228/235.0
VIVKDTFEKS--PNCSLAVHCVAGLGRAPVLVAIALIEKGMKY------HEAVDFIRNKRRGAINK-RQLDF
 ....  ...   . .. ||| || ||. ..||. .. . ..        ..|  .|..|.|....  |. |
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYif
Y_phosphatase Protein-tyrosine phosphatase 97-159 7e-08 27.5 In-house 157-228 (235) alignment 
Range on Protein: 97-159
Range on HMM: 157-228/235.0
VIVKDTFEKS--PNCSLAVHCVAGLGRAPVLVAIALIEKGMKY------HEAVDFIRNKRRGAINK-RQLDF
 ....  ...   . .. ||| || ||. ..||. .. . ..        ..|  .|..|.|....  |. |
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYif
subfamily_DSP11_pd Subfamily DSP11 63-155 3.4e-07 24.3 In-house 69-164 (178) alignment 
Range on Protein: 63-155
Range on HMM: 69-164/178.0
SYSSEPLKAKGIDVIDLQFDDGGSPPEDIIRQWLVIVKDTFE--KSPNCSLAVHCVAGLGRAPVLVAIALIE-KGMKYHEAVDFIRNKRRGAINKR
 |. . |...|.    |.      | |......   ||.  |  |  .  ..|||  |. |.  |.   ||. .|.. ..|..   . |  .... 
yykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslere
subfamily_DSP3_pd Subfamily DSP3 107-165 6.1e-07 23.2 In-house 96-155 (162) alignment 
Range on Protein: 107-165
Range on HMM: 96-155/162.0
PNCSLAVHCVAGLGRAPVLV-AIALIEKGMKYHEAVDFIRNKRRGAINKRQLDFLENYKS
..  . ||||.|. |...|| |  .| . |. .||.  .|.||.   |.  |  | ....
kegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaelde
Glyco_trans_4_2 Glycosyl transferase 4-like 31-82 1.6e-06 14.4 Pfam-A 3-53 (139) alignment 
Range on Protein: 31-82
Range on HMM: 3-53/139.0
LIINNPTSATLPNFINELEKNQAKIVVRCCEPSYsSEPLKAKGIDVIDLQFD
|.. |  |  . ..|.||...  .. . . ....  . ..|.||.|..|...
lllgnlssthtlkwikelkergyevhiitpdkdk.knveeaegikvhrlpsp
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 94-143 2e-06 22.2 In-house 203-252 (297) alignment 
Range on Protein: 94-143
Range on HMM: 203-252/297.0
QWLVIVKDTFEKSPNCSLAVHCVAGLGRAPVLVAIALIEKGMKYHEAVDF
...  |...|..  .. | |||.||.||. ||..|  .   .| ...|| 
klisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdi
subfamily_DSP15_pd Subfamily DSP15 109-152 2.1e-06 21.9 In-house 79-123 (151) alignment 
Range on Protein: 109-152
Range on HMM: 79-123/151.0
CSLAVHCVAGLGRAPVLVAIALIE-KGMKYHEAVDFIRNKRRGAI
 .  |||.||. |.  ||.. |.    .....|...|...|  | 
envlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvan
subfamily_DSP8_pd Subfamily DSP8 105-161 4e-06 20.5 In-house 90-145 (159) alignment 
Range on Protein: 105-161
Range on HMM: 90-145/159.0
KSPNCSLAVHCVAGLGRAPVlVAIALIEKG--MKYHEAVDFIRNKRrGAINKrQLDFLE
|| |..  ||. ||  |..  |||| | |   |.. ||  |...||  .|.. .| ||.
ksengrvlvhvlaGisrsat.vaiayimktlemsldeayrfvkekr.ptisp.nlnflg
subfamily_DSP1_pd Subfamily DSP1 107-149 4.9e-06 20.7 In-house 94-137 (163) alignment 
Range on Protein: 107-149
Range on HMM: 94-137/163.0
PNCSLAVHCVAGLGRAPVLVAIALI-EKGMKYHEAVDFIRNKRR
 |  . .|| ||. |.  |. . |. .| ....|| ||....| 
knGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRs
subfamily_DSP19_pd Subfamily DSP19 104-151 6e-06 20.7 In-house 83-133 (152) alignment 
Range on Protein: 104-151
Range on HMM: 83-133/152.0
EKSP--NCSLAVHCVAGLGRAPVL-VAIALIEKGMKYHEAVDFIRNKRRGA
|..   .  . ||| ||  |.. . .|  . .. ....||.. .|..|. .
eearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpci
subfamily_STYX_pd Subfamily STYX 85-154 8.9e-06 18.9 In-house 72-142 (166) alignment 
Range on Protein: 85-154
Range on HMM: 72-142/166.0
GSPPEDIIRqWLVIVKDTFEKSP--NCSLAVHCVAGLGRAPVLVAIALIE-KGMKYHEAVDFIRNKRRgAINK
 .. |.||| .|  ||.  ..|      . ||  ||. |.  ||   ..|  |.|| ||  .....|   || 
dntveniir.ylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrf.cinp