Gene PTPMT1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPMT1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP014_AA protein Get Run
AqueP014_AA_45-197 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPMT1_pd Subfamily PTPMT1 29-198 4.8e-74 242.4 In-house 1-171 (171) alignment 
Range on Protein: 29-198
Range on HMM: 1-171/171.0
YFPTLVRLIFKQKVSITNWYDRIDDTVILGALPFRSMTKELVEGEKVRAVLSYNQDYELKLFTNSLKDWEKNGVKQYVYPTWDFT-PPTQKHIADGLFVI
..|||.. ....|.| .|||||||||||||||||||..|||.| |.|.||.|.|..||||...|| ..|.|.||.|. ..|.|||  |.......|. .|
fyPtllynvlvekaskrnwydriDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefi

DRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYENLIHK
.... ....||||||||.|||||.||||.||..|. |..|......||..||....|..|..|..|.|..|
ekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekllsk
PTEN_1 47-195 5.7e-36 119.2 In-house 40-191 (196) alignment 
Range on Protein: 47-195
Range on HMM: 40-191/196.0
WYDRIDDTVILGALPFRSMTKELVEGEKVRAVLSYNQDYELKLFTNSLKDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDRERLN---KSSVYVHCKA
 ...||.....| |.. .. ..  .......|.. . ..||. .. .|....|.||... .|  |...|.  .. | . ...  .|.   .  |.|||||
llqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCka

GKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYENL
|.|||.||||.| |...|. .|.|.... .|||... || ....  |....|
GlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0044763 (Phosphotyrosine protein) phosphatases II 43-196 3.4e-33 110.2 In-house 18-171 (178) alignment 
Range on Protein: 43-196
Range on HMM: 18-171/178.0
SITNWYDRIDDTVILGALPFrSMTKELVEGEKVRAVLSYNQDYELKLFTNSLKDWEKNGVKQYVYPTWDFTPPT-QKHIADGLFVIDRER-LNKSSVYVH
|  .....|.. ..||.||  .. .||.  ........ ....||  . .  ...|..|.. . .|. |...|.  .|. . .  |.. .  ... |.||
sdyinaseilpglylgslpp.addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPqIRMNSHQRQAITEFYENLI
|.||.|||.|.||.| ||.... ...||... ..|| |  | .|.. . ||.. | 
CsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
0046846 (Phosphotyrosine protein) phosphatases II 44-195 2.3e-32 107.5 In-house 8-172 (176) alignment 
Range on Protein: 44-195
Range on HMM: 8-172/176.0
ITNWYDRIDDTVILGALP----------FRSMTKELVEGeKVRAVLSYNQDYELKLF--TNSLKDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDRER
  ...|.|.. .|||..|          . .  ..| |  ...||.. ....||. .  .|  ...||.|.. ...|. |...|. ... . |  |.. .
ldldldyinanlilgsrpiatqgplprtladflemlkel.gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefireal

LNKSSVYVHCKAGKGRSATVVACYVMKR-YKMVPDDAIDFIERKRP-QIRMNSHQRQAITEFYENL
 ..  |.|||.||.||..|.||.| ... . . ...|.... ..|| ..  . .|.. . ||.  |
keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0038934 (Phosphotyrosine protein) phosphatases II 45-196 4.9e-30 100.0 In-house 10-177 (194) alignment 
Range on Protein: 45-196
Range on HMM: 10-177/194.0
TNWYDRIDDTVILGALPFRSMTKELVEGEKVRAVLSYNQDYELK-------------LFTNSLKDWEKNGVKQYVYPTWD-FTPPTQKHIADGLFVIDR-
... |.| . .|  ..|  ..  . .|.... .. .. . ..|.              .. . ...||.|.. . .|. | .|.|... . . | ..|. 
ervgdiitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdef

-ERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYENLI
 .. ..  |.||||||.||..|.||.| ..|..| ...||.....||| . .| .. .|. ..|..|.
lnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr
0048076 (Phosphotyrosine protein) phosphatases II 46-195 1.3e-28 94.9 In-house 2-142 (145) alignment 
Range on Protein: 46-195
Range on HMM: 2-142/145.0
NWYDRIDDTVILGALPfRSMTKELVEGEKVRAVLSYnqdyelklfTNSLKDWEKNGVKQYVYPTWDFTPPTQ-KHIADGLFVIDRERLNKSSVYVHCKAG
.|...|.. . || ||   .  || .  ....||.          |. |...|..|.. . .|..|...|.  ... . |  |.. . ..  |.|||.||
ywpseilpglylgslp.taldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaG

KGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYENL
.||..|.||.|.|..... ...|.... ..||.. .| .|.. . ||.. |
vgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 46-193 6.6e-28 92.6 In-house 2-142 (144) alignment 
Range on Protein: 46-193
Range on HMM: 2-142/144.0
NWYDRIDDTVILGALPfRSMTKELVEGEKVRAVLSYNQDYELKLFTNSlkdweknGVKQYVYPTWDFTPPTQ-KHIADGLFVIDRERLNKSSVYVHCKAG
.....|.. . || ||  ..  ||    ....|.. . .||   ...        |.. . .|. |. .|.  ... . |  |.. . ..  |.|||.||
snpseilpglylgslp.taldlellkklgittvinlteeyepeflere.......giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaG

KGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYE
.||..|.||.|.||.... ...|.... ..||.. .| .|.. . |...
vgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0036282 (Phosphotyrosine protein) phosphatases II 50-191 1.3e-27 92.0 In-house 14-165 (174) alignment 
Range on Protein: 50-191
Range on HMM: 14-165/174.0
RIDDTVILGALPFRsmTKELVEGEKVRAVLSYNQDYELK------LFTNSLKDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDRERLN--KSSVYVHC
.| . .|.|. |..    |..  .....|..... .||.      ..    .|.|..|.. . .|. |...|.   . . .  ... ...  .  |.|||
yitprliagqgpla..fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHC

KAGKGRSATVVACYVMKRYKM-VPDDAIDFIERKR---PQIRMNSHQRQAITEF
.||.||..|.||.| |.|...  ..||.|.. ..|   |..  . .|.. . .|
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
0049772 (Phosphotyrosine protein) phosphatases II 93-193 8.8e-27 90.1 In-house 172-271 (314) alignment 
Range on Protein: 93-193
Range on HMM: 172-271/314.0
SLKDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDRErLNKSSVYVHCKAGKGRSAT-VVACYVMKRYKMVPDDAIDFIERKRPqIRMNSHQRQAITEF
. ...|..|.| . .|..|...|. ... . | .|..   ... |.|||||||||..| |||.|.||.... ...|.... .||| |..| ....   ..
dpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqy

YE
..
ef
0043147 (Phosphotyrosine protein) phosphatases II 65-195 1e-26 89.1 In-house 35-160 (172) alignment 
Range on Protein: 65-195
Range on HMM: 35-160/172.0
MTKELVEGEKVRAVLSYNQDyelklfTNSLKDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDR--ERLNKSSVYVHCKAGKGRSATVVACYVMKrYKM
.  ...  ........ ..       ..  .. |..|.. . .|  |...|. ... . |  ||.   . ..  |.|||.||.||..|.||.| |. ...
dfwrmlkelgithivnltel......lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lgl

VPDDAIDFIERKRPQIRMNSHQRQAITEFYENL
 ...|.... .|||..  | .|.. . .| . |
sleeavalvrekRpgavqnpsqyrflyyfekll
0045098 (Phosphotyrosine protein) phosphatases II 45-197 2e-26 88.4 In-house 36-273 (278) alignment 
Range on Protein: 45-197
Range on HMM: 36-273/278.0
TNWYDRI--------------------DDTVILGALPFRSMT---KELVEGEKVRAVLSYNQDYELK---------------------------------
 |.|  |                    ... |. . |. | .    ...  ........ .. .||.                                 
knRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddyt

-------LFTNSLKDWEKNGVKQYVY-PTWDFTPPTQK---HIADGLFVIDRERL--------------NKSSVYVHCKAGKGRSATVVACYVMKRY---
        .|.  .|.|..||... | |  |...|..    .. . |  |.. .               ..  |.|||.||.||..|.||.| |...   
lrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleg

KMVPDDAIDFIERKRPQ-IRMNSHQRQAITEFYENLIH
.. ...|.... ..||. . .| .| . . ||   |..
gvdlleavkelrsqRpglavqnleqyrflyefllelll
0049260 (Phosphotyrosine protein) phosphatases II 68-193 4.6e-26 86.7 In-house 27-147 (152) alignment 
Range on Protein: 68-193
Range on HMM: 27-147/152.0
ELVEGEKVRAVLSYNQDYElklftnSLKDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDRE--RLNKSSVYVHCKAGKGRSATVVACYVMKrYKMVPD
...   ............|        |...... . . .|. |...|.   . . |. ....  . ..  |.|||.||.||..|.||.| |. ... ..
rmlkelgittivmltelle......lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsle

DAIDFIERKRPQIRMNSHQRQAITEFYE
.|.... .|||..  | .|.. . ||..
eavalvrekRpgavpnpgqlrflyefek
0042113 (Phosphotyrosine protein) phosphatases II 19-192 1.1e-25 85.9 In-house 11-239 (245) alignment 
Range on Protein: 19-192
Range on HMM: 11-239/245.0
AFHRLLARVLYFPTLVRLIFKQKVSITNWY-------DRIDDTVILGALPFRSmTKE----LVEGEKVRAVLSYNQDYELKL------------------
 ..|    ..|  |.|.|   .    .. .       .|| ...|... | .. | |    ..  ........ ... ||.                   
dknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdf

-------------------FTNSLKDWEKNGVKQYVYPTWDFTPPT-QKHIADGLFVIDRERL--NKSSVYVHCKAGKGRSATVVACYVM-----KRYKM
                    ||  .|......  . .|  |...|.  ... | |  ... .   ..  |.|||.||.||..|..|.| |     |....
tvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgv

VPDDAIDFIERKRPQIRMNSHQRQAITEFY
 ...|.... ..||..... .| . . |. 
sleeavkelrsqRpgavqtpsqyrflyeal
0041856 (Phosphotyrosine protein) phosphatases II 41-191 3.5e-25 84.0 In-house 17-166 (182) alignment 
Range on Protein: 41-191
Range on HMM: 17-166/182.0
KvsitnWYDRIDDTVILGALPFR-------------SMTKELVEGEKVRAVLSYNqdyelkLFTNSLKDWEKNGVKQYVYPTWDFTPPTqkhIADGLFVI
      ..|.| . ..||.||..              .  ... ......... .       .    ...|..|.. . .|  |...|.   . . |  |
r.....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd...ldelldfi

DRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEF
.. . ..  |.|||.||.||..|.||.|.||.... ...|.... ..||..  . .| . .  .
eevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqla
0051082 (Phosphotyrosine protein) phosphatases II 47-188 3.7e-24 80.4 In-house 7-145 (151) alignment 
Range on Protein: 47-188
Range on HMM: 7-145/151.0
WYDRIDDTVILGALPfRSMTKELVEGEKVRAVLSYNQDYELKlftNSLKDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDRERLN--KSSVYVHCKAG
.. .... ..... |  .   ||.. ........ ....| .   .  . ....|.. . .| .|...|.  .. | .  . .. |.  .  |.|||.||
nfsyvtgglyrsggp.ladflellkelgiktivnlrseeerg...ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaG

KGRSATVVACYVMKrYKMVPDDAIDFIERKRPQIRMNSHQRQAI
|||..|.||.| |. ... ...|.... .||| .   . |.. .
kgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfq
0037934 (Phosphotyrosine protein) phosphatases II 35-192 9.8e-24 79.7 In-house 28-238 (243) alignment 
Range on Protein: 35-192
Range on HMM: 28-238/243.0
RLifKQKVSITNWYDRIDDTVILGALPFRSMTKE-------LVEGEKVRAVLSYNQDYELKLF------------------------------------T
.|  .    |   . .. ...|.. .|  .....       ..  ........ ....||. .                                     
kl..egsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllen

NSLKDWEKNGVKQYVYPTWDFTPPT-QKHIADGLFVIDR---------ERLNKSSVYVHCKAGKGRSATVVACYVMKRY-KMVPDDAIDFIERKRPQ-IR
 .|.|....... . .|  |...|.  ... | |  .            . ... |.|||.||.||..|..|.|.|... .. ...|.... ..||. . 
ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkav

MNSHQRQAITEFY
 . .|.. . |..
qtpsqyrflyeal
0039614 (Phosphotyrosine protein) phosphatases II 21-191 6.8e-23 77.0 In-house 60-284 (297) alignment 
Range on Protein: 21-191
Range on HMM: 60-284/297.0
HRLLARVLYFPTLVRLIFKQKV---------SITNWYDRIDDTVILGALPFRSMT---KELVEGEKVRAVLSYNQDYEL---------------------
.|    . |  . |.|  . .|         |  . ||......|.   |  . .    ..|  ..|..... ..  ||                     
nrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvt

------------KLFTNSLkDWEKNGVKQYVYPTW-DFTPP-TQKHIADGLFVIDRERL---NKSSVYVHCKAGKGRSATVVACYVM-----KRYKMVPD
              .. .  . |   |... |. | |...| . ... . |  ... .    ..  |.|||.||.||..|..|.| |     |.... ..
llkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvl

DAIDFIERKRPQIRMNSHQRQAITEF
.|.... ..||..... .| . . ..
eavkelreqRpgavqtpsqyrflyda
0040438 (Phosphotyrosine protein) phosphatases II 73-194 2.2e-20 68.6 In-house 109-274 (317) alignment 
Range on Protein: 73-194
Range on HMM: 109-274/317.0
EKVRAVLSYNQDYELK------------------------------------LFTNSLKDWEKNGVKQYVYPTW-DFTPP-TQKHIADGLFVIDRERLN-
..|. ... ..  ||.                                    |    |.| |.  |... |..| |...| . ... | |  ... . . 
qgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedp

KSSVYVHCKAGKGRSATVVACYVM-----KRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYEN
.. | |||.||.||..|..|.|.|     |.... ...|.... ..||..  .  | . . ..  .
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
0040439 (Phosphotyrosine protein) phosphatases II 50-193 5.2e-20 67.6 In-house 51-243 (249) alignment 
Range on Protein: 50-193
Range on HMM: 51-243/249.0
RIDDTVILGALPFRSMT---KELVEGEKVRAVLSYNQDYEL------------------------------------KLFTNSLKDWEKNGVKQYVYPTW
.| ...|.   |  ...    ...  ........ ... ||                                    .|    |.| |.  |... |. |
yikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdw

DF--TPPTQKHIADGLFVIDRERL---NKSSVYVHCKAGKGRSATVVACYVM-----KRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYE
    .||. ... | .  ..  .    ... |.|||.||.||..|..|.| |     |.... ...|.... ..||.. .| .| . . |.  
pdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0045450 (Phosphotyrosine protein) phosphatases II 68-192 7.1e-20 67.4 In-house 125-300 (307) alignment 
Range on Protein: 68-192
Range on HMM: 125-300/307.0
ELVEGEKVRAVLSYNQDYELKL------------------------------------FTNSL--KDWEKNGVKQYVYPTW-DFTPP-TQKHIADGLFVI
...  ..|..... ... ||.                                     .. .   .. |   |... |..| |.. | . ... | .  .
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

DR--ERL-NKSSVYVHCKAGKGRSATVVACYVMKRYK--------MVPDDAIDFIERKRPQIRMNSHQRQAITEFY
..  |.| ... |.|||.||.||..|..|.|.|.|.         . ...|.... ..||..  | .| . . |. 
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
PTPc_motif_SM00404 50-192 1.2e-19 65.5 In-house 4-138 (140) alignment 
Range on Protein: 50-192
Range on HMM: 4-138/140.0
RIDDTVILGALPFRSmTKELVEGEKVRAVLSYNQDYELKlftnslkdWEKNGVKQYVYPTWD-FTPPTQKHIADGLFVIDRERLNKSSVYVHCKAGKGRS
|| . ..|| ..  .  ..| .  ....|..  .  .|.         |..|..   .|  |  . ...|..   | .|.. . .. .|.|||.||  ||
rilphlylgskskaq.npallkklgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRS

ATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFY
||....|.|.....  ..|..|....||.|. | .  . . |..
atliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
0043336 (Phosphotyrosine protein) phosphatases II 52-191 2.7e-19 65.2 In-house 87-272 (278) alignment 
Range on Protein: 52-191
Range on HMM: 87-272/278.0
DDTVILGALPFRSMT---KELVEGEKVRAVLSYNQDYELKL----------------------------------FTNS-LKDWEKNGVKQYVYPTW-DF
 ...|.   |  . .    ..|  ..|. ... ... ||.                                   .. . |.| |.  | .| |. | |.
prkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdh

TPP-TQKHIADGLFVIDRERL-NKSSVYVHCKAGKGRSATVVACYVM-----KRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEF
. | . ... | | .... .  ... |.|||.||.||..|..|.|..     |.... ...|.... ..||.. ..  | . . |.
gvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
DSPc Dual specificity phosphatase, catalytic domain 100-192 6.8e-19 63.1 Pfam-A 38-131 (133) alignment 
Range on Protein: 100-192
Range on HMM: 38-131/133.0
NGVKQYVYPTWD-FTPPTQKHIADGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFY
.  ..  .|  |  .  ..|.. .   .|.. . .. .|.|||.||  ||||....| ||....  ..|..|....|..|. | .. . . |..
seieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 100-192 6.8e-19 63.1 In-house 38-131 (133) alignment 
Range on Protein: 100-192
Range on HMM: 38-131/133.0
NGVKQYVYPTWD-FTPPTQKHIADGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFY
.  ..  .|  |  .  ..|.. .   .|.. . .. .|.|||.||  ||||....| ||....  ..|..|....|..|. | .. . . |..
seieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLleye
0051429 (Phosphotyrosine protein) phosphatases II 68-196 2.1e-18 62.4 In-house 40-225 (272) alignment 
Range on Protein: 68-196
Range on HMM: 40-225/272.0
ELvEGEKVRAVLSYNQDYELKLFTNSLKDwekNGVKQYVYPTWDFTPPTQKHIA----------------------------------------------
 | . ........  ...|.. .  ..      |.. ...|..|...||  ..|                                              
rl.kelgiktivdLrseeErgrlkcdryw...pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgv

--DGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKrYKMV--------------PDDAIDFIERKRPQIRMNSHQRQAITEFYENLI
  . |  . .. |..  |.|||.|||.|..||||.. .  . .               ...|.. . ..||... . .|.. . |.. .|.
pqeallellellldggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
0036941 (Phosphotyrosine protein) phosphatases II 82-196 4.6e-18 61.0 In-house 149-277 (297) alignment 
Range on Protein: 82-196
Range on HMM: 149-277/297.0
NQDYELKLFTNSL-KDWEKNGVKQYVYPTWDFTPPT--QKHIADGLFVIDRERL---NKSSVYVHCKAGKGRSATVVACYVM--------KRYKMVPDDA
..|| |  .. .  .. |.  |... |..|.   .    ... | .  ... .    ... |.|||.||.|||.|..|...|        |.... . .|
lddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdilea

IDFIERKRPQIRMNSHQRQAITEFYENLI
. .. ..||..  .  | . . |.  .|.
vkklReqRpgavqtleqyrflyeallell
subfamily_PTPDC1_pd Subfamily PTPDC1 90-198 9.8e-18 59.2 In-house 71-178 (182) alignment 
Range on Protein: 90-198
Range on HMM: 71-178/182.0
FTNSLKDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDReRLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAIT
|. .|... ..|.  | ..  |.  .. ..| |   |..   |..  | ||| ||.||   ..|||..   .. ...||...  |||.     .| . ..
fsYdlealmeqgiyvynfgwkDygvasleriLdivkvvaf.alqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvk

EFYENLIHK
||.  ||..
efalflipl
0047943 (Phosphotyrosine protein) phosphatases II 80-189 1.4e-17 59.5 In-house 107-265 (273) alignment 
Range on Protein: 80-189
Range on HMM: 107-265/273.0
SYNQDYEL--------------------------------------KLFTNS-LKDWEKNGVKQYVYPTW-DFTPP-TQKHIADGLFVIDRERL---NKS
. ....||                                        .. . |.. |.  |... |..| |.  | . ... . . .... .    ...
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

SVYVHCKAGKGRSATVVACYVM-----KRYKMVPDDAIDFIERKRPQIRMNSHQRQAIT
 |.|||.||.||..|..|....     |.... ...|. .. ..|| . ..  |.. . 
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0050432 (Phosphotyrosine protein) phosphatases II 84-189 3.8e-17 58.0 In-house 180-292 (308) alignment 
Range on Protein: 84-189
Range on HMM: 180-292/308.0
DYELKLFTNSL-KDWEKNGVKQYVYPTW-DFTPPTQ-KHIADGLFVIDRERlNKSSVYVHCKAGKGRSATVVACYVM-----KRYKMVPDDAIDFIERKR
|| .  .. .  .| |   |... |..| |.  |.. ... | |  ... . ... ..|||.|| ||..|..|....     | ... . .|. .. ..|
dytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR

PQIRMNSHQRQAIT
|.   .  | . . 
pgmvqtpeqylfly
0048567 (Phosphotyrosine protein) phosphatases II 78-192 2.9e-16 54.2 In-house 4-135 (157) alignment 
Range on Protein: 78-192
Range on HMM: 4-135/157.0
VLSYNQDYELKLFTNSLKDWEKNGVKQYVY----------PTWDFTPPTQKHIADGLFV----IDRERLNKSSVYVHCKAGK---GRSATVVACYVMKRY
..... ... .|. ..|  ..|. .. ...          . .|| |..  .. .   .    ..  .|..  ..||||||    ||.||...|| ....
ngdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhl

KMVPDDAIDFIERKRPQIRMNSHQRQAITEFY
.. |..||...   || . .   . ...  ..
gftpeeaiaplrivrpgsvpfrdasyllslyn
subfamily_DSP23_pd Subfamily DSP23 111-196 4.1e-16 53.9 In-house 61-145 (148) alignment 
Range on Protein: 111-196
Range on HMM: 61-145/148.0
DFTPPTQKHIADGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEfYENLI
|..||. . . . . |..    .. .| |||  |.||. |..|||..|  |.   .||  . |.||       | ... . || .|
dyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklvrd.yetfi
subfamily_DSP6_pd Subfamily DSP6 116-195 9.1e-16 51.8 In-house 75-154 (158) alignment 
Range on Protein: 116-195
Range on HMM: 75-154/158.0
TQKHIADGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYENL
 .|.. . .  ||  | .||.| ||| ||  || ||. .|.||....  .|| |........|  | .  . ...| ..|
lakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0046845 (Phosphotyrosine protein) phosphatases II 83-191 1e-15 53.3 In-house 146-269 (284) alignment 
Range on Protein: 83-191
Range on HMM: 146-269/284.0
QDYELKLFTNSLK--DWEKNGVKQYVYPTW-DFTPPT-QKHIADGLFVIDRERLN---KSSVYVHCKAGKGRSATVVACYVMKRY--------KMVPDDA
.|| .  .. . .  . |   |... |..| |.  |.  ... . |  ... . |   .. . |||.||.||..|..|.......        .. . .|
ddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvlea

IDFIERKRPQIRMNSHQRQAITEF
. .. ..||.   .  | . . |.
vkrlreqRpgmvqtleqyrfvyea
0051299 (Phosphotyrosine protein) phosphatases II 82-188 1.2e-15 53.3 In-house 159-278 (288) alignment 
Range on Protein: 82-188
Range on HMM: 159-278/288.0
NQDYELKLFTNSL-----KDWEKNGVKQYVYPTW-DFTPPT-QKHIADGLFVIDRERLN-KSSVYVHCKAGKGRSATVVACYVM-----KRYKMVPDDAI
..|| .  .. .      .| |.  |... |..| |.  |.  ... | |  ... . . .. |.|||.||.||..|..|....     |.... . .|.
lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

DFIERKRPQIRMNSHQRQAI
 .. ..||..  .  | . .
krlreqRpgmvqtpeqyrfv
subfamily_DSP12_pd Subfamily DSP12 118-183 1.5e-15 51.9 In-house 66-131 (155) alignment 
Range on Protein: 118-183
Range on HMM: 66-131/155.0
KHIADGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSH
.|. . .  |.  . .. .|.|||.||  ||.|.|. |.||..|.  ..|......|.|.|..|  
shldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNeg
subfamily_DSP8_pd Subfamily DSP8 126-197 3e-15 50.2 In-house 85-156 (159) alignment 
Range on Protein: 126-197
Range on HMM: 85-156/159.0
VIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYENLIH
 ||. . ....| ||. ||. |||||. .|.||. .|  |.|  |.  ||| |  |    . . |....|  
fidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
subfamily_DSP10_pd Subfamily DSP10 118-197 9.3e-15 48.8 In-house 76-155 (159) alignment 
Range on Protein: 118-197
Range on HMM: 76-155/159.0
KHIADGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYENLIH
..  . |  |.  | . |.| |||.||  ||||||  |.||. ..   || .|.. ||| |  |      . || ..| .
qyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
subfamily_Slingshot_pd Subfamily Slingshot 120-194 9.4e-15 48.4 In-house 82-155 (169) alignment 
Range on Protein: 120-194
Range on HMM: 82-155/169.0
IADGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEfYEN
  .    |.. . ..|.| |||| |  |||..|  | ||.|..  ..|.......|  |. |.   . ..| || 
wnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqlee.yeG
subfamily_LRR-DSP_pd Subfamily LRR-DSP 127-196 2.1e-13 44.0 In-house 191-259 (263) alignment 
Range on Protein: 127-196
Range on HMM: 191-259/263.0
IDRERlNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYENLI
|.  | .|  | |||.||  ||.|.| .|.||. ..   .|.|.. .|||.|. |   .. .  . ..| 
ieeGr.kkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_DSP15_pd Subfamily DSP15 116-194 2.4e-13 44.5 In-house 60-138 (151) alignment 
Range on Protein: 116-194
Range on HMM: 60-138/151.0
TQKHIADGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYEN
 .|.. .   .| . ||.. .|.||| ||  ||.|.|. |.|   ..   ||...|. .|     |   .. . |. ..
lskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
subfamily_DSP1_pd Subfamily DSP1 127-196 2.4e-13 44.5 In-house 88-157 (163) alignment 
Range on Protein: 127-196
Range on HMM: 88-157/163.0
IDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYENLI
||. . ..  |..||.||  ||.|..  |.||. ..  ..| ||. ..|. |. |    . . .. ..| 
idevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_CDC14_pd Subfamily CDC14 95-187 2.6e-13 44.5 In-house 227-315 (328) alignment 
Range on Protein: 95-187
Range on HMM: 227-315/328.0
KDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDRErlnKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIrMNSHQRQA
| ....|.. .     | . |... .   | ....    . .. |||||| ||  |..|||.||.|..   .|| ..   ||   . ..|.. 
kkftdaGfdhkDlffiDGstPsdaivkkfleiaeka...eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGs.vigpqqkf
subfamily_DSP19_pd Subfamily DSP19 127-188 4.3e-13 43.9 In-house 82-143 (152) alignment 
Range on Protein: 127-188
Range on HMM: 82-143/152.0
IDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAI
|.  | ..  |.|||.||  |||.||  |.||. ..   .|.. .  .|| |. |.   . .
ieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqL
subfamily_DSP14_pd Subfamily DSP14 128-196 2e-11 38.1 In-house 77-145 (157) alignment 
Range on Protein: 128-196
Range on HMM: 77-145/157.0
DRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYENLI
.  . ..  . |||.||  |||...  |.||  |.   .|   .. .||.|| |.   . . .. ..| 
eevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklk
subfamily_DSP3_pd Subfamily DSP3 79-182 2.8e-11 37.3 In-house 55-144 (162) alignment 
Range on Protein: 79-182
Range on HMM: 55-144/162.0
LSYNQDYELKLFTNSLKDWEKNGVKQYVYPTWDFTPPTQKHiadglfvidrerlNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRpQI
 .. .| |.| .   ..|  .  ...| ... .|   . ..             ... |.|||..|  ||||.|  |.| | ||   .||  ...|| .|
aefykdleikylGlevdDvpefdlskyFetaakfidealsq.............kegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR.ei

RMNS
. |.
lPne
subfamily_PTEN_pd Subfamily PTEN 101-178 4.5e-10 34.8 In-house 79-159 (184) alignment 
Range on Protein: 101-178
Range on HMM: 79-159/184.0
GVKQYVYPTWDFTPPTQKHIADGLFVIDR--ERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMV-PDDAIDFIERKRPQI
  .  |||  | .||. . ... .  |..  |. .|  | |||||||||. .....|..|. ..  ...|... ...| . 
dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtkn
subfamily_PRL_pd Subfamily PRL 95-190 1.5e-09 32.1 In-house 49-144 (151) alignment 
Range on Protein: 95-190
Range on HMM: 49-144/151.0
KDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDRE--RLNKSSVYVHCKAGKGRSATVVACYVMKRyKMVPDDAIDFIERKRpQIRMNSHQRQAITE
.  ||.|..   ..  | ..|... . . | .. ..  . .||.| ||| || ||.  .||  ..    | ..||..|| .|| .  .||.| . . .
eklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmkyedavefirekr.rgainskqlkflek
PTPc_DSPc_SM00012 102-176 4.1e-09 31.9 In-house 2-87 (105) alignment 
Range on Protein: 102-176
Range on HMM: 2-87/105.0
VKQYVYPTWDFT--PPTQKHIADGLFVIDRERLNK---SSVYVHCKAGKGRSATVVACYVMKRYK------MVPDDAIDFIERKRP
||.| |..|  .  | ....| . |  ..... ..   ..| |||.|| ||..|.|| ... .        .   . .  . ..||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRp
Y_phosphatase Protein-tyrosine phosphatase 80-158 7e-09 30.8 Pfam-A 111-194 (235) alignment 
Range on Protein: 80-158
Range on HMM: 111-194/235.0
SYNQDYELKLFTNSLKDWEK--NGVKQYVYPTWD--FTPPTQKHIADGLFVIDRER-LNKSSVYVHCKAGKGRSATVVACYVMK
. ...| |. .. . |..|.  . |||. | .|    .| ..|.. | .  . ...  ....| |||.|| ||..|.||  .. 
edekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
Y_phosphatase Protein-tyrosine phosphatase 80-158 7e-09 30.8 In-house 111-194 (235) alignment 
Range on Protein: 80-158
Range on HMM: 111-194/235.0
SYNQDYELKLFTNSLKDWEK--NGVKQYVYPTWD--FTPPTQKHIADGLFVIDRER-LNKSSVYVHCKAGKGRSATVVACYVMK
. ...| |. .. . |..|.  . |||. | .|    .| ..|.. | .  . ...  ....| |||.|| ||..|.||  .. 
edekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
subfamily_STYX_pd Subfamily STYX 133-192 2.7e-08 27.1 In-house 95-154 (166) alignment 
Range on Protein: 133-192
Range on HMM: 95-154/166.0
NKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFY
.   | || .||  |||..| .|.|. | .   .|  .....|  | .|.   . ..|. 
kggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye
DSPc_SM00195 75-157 5.3e-08 27.9 In-house 138-218 (263) alignment 
Range on Protein: 75-157
Range on HMM: 138-218/263.0
VRavlsynQDYELKLFTNSLKDW-EKNGVKQYVYPTWDF--TPPTQKHIADGLFVIDRERL-NKSSVYVHCKAGKGRSATVVACYVM
..      ....|. .. . ..  |.  |.|| | .|    .| ..|.. . | ... ..  ... . |||.|| ||..|.|.  ..
kk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii
PTPc_SM00194 75-157 5.3e-08 27.9 In-house 138-218 (263) alignment 
Range on Protein: 75-157
Range on HMM: 138-218/263.0
VRavlsynQDYELKLFTNSLKDW-EKNGVKQYVYPTWDF--TPPTQKHIADGLFVIDRERL-NKSSVYVHCKAGKGRSATVVACYVM
..      ....|. .. . ..  |.  |.|| | .|    .| ..|.. . | ... ..  ... . |||.|| ||..|.|.  ..
kk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii
subfamily_MSG5_pd Subfamily MSG5 104-178 5.3e-08 26.2 In-house 69-143 (165) alignment 
Range on Protein: 104-178
Range on HMM: 69-143/165.0
QYVYPTWDFTPPTQKHIADGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQI
.| .  |. .    | ..    .|   . ..  . |||. |  |||...  |.|| |..   || | .  .  .|
kyyhiewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddi
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 122-181 7.1e-08 25.7 In-house 68-127 (145) alignment 
Range on Protein: 122-181
Range on HMM: 68-127/145.0
DGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMN
.    ||. . . . |.||| ||  || ||   ..||  .|   .|   .. .| .   |
evtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypn
subfamily_Ptp69D_pd Subfamily Ptp69D 98-173 7.2e-08 26.9 In-house 180-257 (307) alignment 
Range on Protein: 98-173
Range on HMM: 180-257/307.0
EKNGVKQYVYPTW-DFTPPT-QKHIADGLFVI-DRERLNKSSVYVHCKAGKGRSATVVACYVMKRyKMVPDDAIDFIER
... | || | .| |.. |   . . . .  . . ..||.| . |||.|| |||...||  ..   ..  .| .| .| 
dsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllq.qlkaedkvdifet
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 132-183 1.2e-07 25.2 In-house 89-140 (154) alignment 
Range on Protein: 132-183
Range on HMM: 89-140/154.0
LNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSH
.... | ||...|  |||...  |.|.. |.    |. ..   |..|. |  
vennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqG
subfamily_Laforin_pd Subfamily Laforin 93-182 2.2e-07 24.0 In-house 68-158 (183) alignment 
Range on Protein: 93-182
Range on HMM: 68-158/183.0
SLKDWEKNGVKQYVYPTWDFTPPT-QKHIADGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNS
  | . ..|.     || |..  .  . . ......     .   |||||.|| |||...|  ...   .        |.  ||| . .. 
lkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyide
subfamily_STYXL1_pd Subfamily STYXL1 125-192 3.2e-07 23.7 In-house 83-150 (157) alignment 
Range on Protein: 125-192
Range on HMM: 83-150/157.0
FVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFY
  |.. . ... | |  . |  |||.|...|.|  .|.   .| ..... .. .. |    . ..|. 
qfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWe
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 90-184 6.5e-07 23.6 In-house 163-262 (287) alignment 
Range on Protein: 90-184
Range on HMM: 163-262/287.0
FTNSLKDWEKNGVKQYVYPTWDFTPPTQKHiADGLFVIDRE-----RLNKSSVYVHCKAGKGRSATVVACYV--MKRYKMVPDDAIDFIERKRPQiRMNS
 .|. |. .|. |||| . .|| |   ... .  |.||..      .  ..|. ||| .. ||||. .|  .   |  .    | .. ....| | ...|
vknknkagdkqqvkqyqitnWdstgkvtep.qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriq.kpgs

HQ
 |
vq
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 127-183 6.7e-07 22.9 In-house 79-135 (148) alignment 
Range on Protein: 127-183
Range on HMM: 79-135/148.0
IDRERLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSH
... . .   | ||.. |  ||. ..  ....  ..   .|..... ||. .. |  
vrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnlg
subfamily_CDKN3_pd Subfamily CDKN3 91-174 1.1e-06 22.3 In-house 89-173 (202) alignment 
Range on Protein: 91-174
Range on HMM: 89-173/202.0
TNSLKDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYV-MKRYKMVPDDAIDFIERK
 . |. ... |.  . ||  | . |      . |  .     .     |||  | |||. |.|| . .    . |.|||| .   
rrlldlyqqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdl
subfamily_MKPLT_pd Subfamily MKPLT 135-191 1.6e-06 21.7 In-house 100-156 (164) alignment 
Range on Protein: 135-191
Range on HMM: 100-156/164.0
SSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEF
  |.|||  || ||..|   ...|  .   ..| ...  .|  .. |    . ...|
GrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakf
subfamily_MKPLV_pd Subfamily MKPLV 135-191 1.6e-06 21.7 In-house 100-156 (164) alignment 
Range on Protein: 135-191
Range on HMM: 100-156/164.0
SSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEF
  |.|||  || ||..|   ...|  .   ..| ...  .|  .. |    . ...|
GrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakf
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 45-172 1.8e-06 22.3 In-house 134-258 (325) alignment 
Range on Protein: 45-172
Range on HMM: 134-258/325.0
TNWYDRIDDTVILGALPFRSMTKELVeGEKVRAVLSYNQDYEL---KLFTNSLKDWEKNGVKQYVYPTWDFTpPTQKHIADglfVIDRERLNKSSVYVHC
  | ... ... .|.|  . .| | .  . |  ||   |  .     .    |. |.  ||...      ..  . |.. .    .  .    . . |||
vywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil.qlvkavse...rvtantkastpilvhc

KAGKGRSATVVACYVMKRyKMVPDDAIDFIE
 || ||. . .. | .   |.. .  .|  .
saGvGrtGvfislysala.kvieesrvdifg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 40-181 2.8e-06 21.6 In-house 123-246 (274) alignment 
Range on Protein: 40-181
Range on HMM: 123-246/274.0
QKVSITNWYDRIDdtvilgalpfrsmtkelvegEKVRAVLSyNQDYELKLFTNSLKDWeKNGVKQYVYPTW-DF-TPPTQKHIADGLFVIDRERLNK---
... |.. |. ..                     ||. ... ..||... .. .     .. || | |. | |  .|   ... | .  ....| ..   
edyeiserygdve....................ikvekive.rndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenak

-SSVYVHCKAGKGRSATVVACYVMKRyKMVPDDAIDFIErKRPQIRMN
 ..| ||| || ||    .|  .  | ..  .  .| ..    ..|..
lapvvvhCsaGiGrtGcfiaisiavr.qlreeivvdvlk.ivcnlrld
subfamily_RNGTT_pd Subfamily RNGTT 131-195 5.4e-06 20.2 In-house 110-174 (189) alignment 
Range on Protein: 131-195
Range on HMM: 110-174/189.0
RLNKSSVYVHCKAGKGRSATVVACYVMKRYKMVPDDAIDFIERKRPQIRMNSHQRQAITEFYENL
.  .. . |||. |  |.  ....|.... ..  ..|..   . ||.   . . .. ... |.. 
knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadv
subfamily_PTPRG_pd Subfamily PTPRG 86-169 6.6e-06 19.6 In-house 172-254 (563) alignment 
Range on Protein: 86-169
Range on HMM: 172-254/563.0
ELKLFTNslKDwEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDRERLNKS---SVYVHCKAGKGRSATVVACYVMKRyKMVPDDAID
.|| . .  .| ..  |.|| |..|  .   .. . .  ||. ... ||.    . |||.|| ||. | ..   . . ..  ..|..
klkkkkq..cd.teklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllk.qiqqenavn
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 103-165 6.8e-06 20.3 In-house 179-239 (307) alignment 
Range on Protein: 103-165
Range on HMM: 179-239/307.0
KQYVYPTWDFTPPTQKHIAdGLFVIDRERLNKSSVYVHCKAGKGRSATVVACYVMKRyKMVPD
... .  |      |  ..  . ...  | ..  | ||| || ||| |.||  ...  ||.  
qhlqwenwpdrgvpqinlt.ainlleavrydtnpvvvhcsaGvGrsGtivaislvqd.kmiaG
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 82-177 7.6e-06 20.1 In-house 138-237 (267) alignment 
Range on Protein: 82-177
Range on HMM: 138-237/267.0
NQDYELKLFTNSLKDWEKNGVKQYVYPTWDFTPPTQKHIADGLFVIDRERLNK--SSVYVHCKAGKGRSATVVACYVM-KRYKMVP-DDAIDFIERKRPQ
..||..  .   .|.     |  | |  |.     . ..   . .. ...|..    . |.|..| ||| | .  . . .| |     |  ||. . | |
endyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsq
subfamily_PTPN12_pd Subfamily PTPN12 82-157 8e-06 19.9 In-house 153-230 (290) alignment 
Range on Protein: 82-157
Range on HMM: 153-230/290.0
NQDYELKLFTNSLKdWEKNGVKQYVYPTW-DF-TPPTQKHIADGLFVIDRER-LNKSSVYVHCKAGKGRSATVVACYVM
..|. .. ..   .  |.. |.|. |  | |  .| ..|.. . .  . . .  ... . ||| || ||  |..|   .
dddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyv
subfamily_Auxilin_pd Subfamily Auxilin 133-186 8.1e-06 18.6 In-house 101-155 (166) alignment 
Range on Protein: 133-186
Range on HMM: 101-155/166.0
NKSSVYVHCKAGKGRSATVVACYVM-KRYKMVPDDAIDFIERKRPQIRMNSHQRQ
.|. | |||| |.  ||..|. ...  |    |..|....  ||  | ..  ...
pknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpiglspsekr