Gene RNGTT-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily RNGTT
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP015_AA protein Get Run
AqueP015_AA_14-185 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_RNGTT_pd Subfamily RNGTT 7-197 1.1e-91 299.7 In-house 1-189 (189) alignment 
Range on Protein: 7-197
Range on HMM: 1-189/189.0
PPRWRHCPRKGKVIAGKFFPFKTPLSSEYDKDLAEGNRFPLSMLIAFTECIpGHRMGLVIDLTKTSRYYDKRELLKCGIGHHKITCEGYGAAPNAEQVKE
|.||..||||||.||.||.|||||||..||.|||| |||..|||....... ....|||||||.|||||||.|| |.|| ..|..|.|.|.||.||||||
PerWlnCPrkgkliaekflpfktplskrydddlaeenrfepsmllsylktl.kvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvke

FQTLCVNFFKDHPDDIIGVHCTHGFNRTGFLIVSYLIDVECWDLESAVATFSMARPPGIYKEHYLHELAGRYADGdIGSIVAPPLPEWCFE
|..|. .|||..|...||||||||||||||||||||...|.|..|.|||.|..|||||||||.||.||. ||||    .|.|| ||.||.|
fiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadv.eeaiaapelpdwcle
mRNA_cap_enzyme mRNA capping enzyme, catalytic domain 272-461 5.3e-57 181.9 Pfam-A 1-192 (192) alignment 
Range on Protein: 272-461
Range on HMM: 1-192/192.0
QPVSMDVQNIRFLNEKPYRVSWKADGTRYMLYIKDKgHIYLIDRDNSVFNSPNITFLSRKR--EGEHLRDCVADSELVLDKVDGAVRPRLLIYDIMMFEG
||||.. .|...|..|.| ||.||||.|..|.|..| ..|||||||.|.  .|..|  ...  . ... . . | |||.|.| .  ..| |||||....|
qpvslsrenlkllkqkdYyvseKaDGlRvlllitkk.evylidrdnevylvenlkfplklekekekvhhgtllDGElvidtveeeqklryliyDilaing

SKdVAKCDHQRRMLCIDRELIMPREEA-AKRGIIDKIREPFSVRAKQFWDVSESRM-ILESYVPKLTHENDGLIYNPTNQPYKPGQCQDLLKWK
   |.... . |. .. .|.| ||.|. .| .||..  |||.|| |.|.. . ..  . .. ..|| ||.||||. ....||..|....|||||
el.vserplskRleilkkeiikpraeeklkthiiktelepfkvrlksfilllalekllskkkikklsheiDGLIfqsvdtpYvagrdknllKWK
0038934 (Phosphotyrosine protein) phosphatases II 6-198 1.3e-51 170.4 In-house 2-192 (194) alignment 
Range on Protein: 6-198
Range on HMM: 2-192/194.0
VPPRWRHCPRKGKVIAGKFFPFKTPLSSEYDKDLAEGNRFPLSMLIAFTECIpGHRMGLVIDLTKTSRYYDKRELLKCGIGHHKITCEGYGAAPNAEQVK
.|.||....| |..| |.| .||.|||. .|| . | .||....|. . .   ....|||||||.|.||||..|. | || ..|. ....|..|. |...
lPdrwlkyervgdiitgrfiafkvPlsgsldkyieelyrfspedlvrylkll.nvklglvidltnteryYdpeefekagieylklpfpddgtvPsleill

EFQTLCVNFFKDHPDDIIGVHCTHGFNRTGFLIVSYLIDVECWDLESAVATFSMARPPGIYKEHYLHELAGRYADGDiGSIVAPPLPEWCFEE
.|  |.  |....|. ...|||..|..|||.|...||| . ....| |.|.|...||..|.. .||..|  || .    . .||. ||...| 
rfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr.kavlapekpellled
subfamily_DSP11_pd Subfamily DSP11 6-177 1.1e-43 143.2 In-house 1-173 (178) alignment 
Range on Protein: 6-177
Range on HMM: 1-173/178.0
VPPRWRHCPRKGKVIAG-KFFPFKTPLSSEYDKDLAEGNRFPLSMLIAFTECiPGHRMGLVIDLTKTSRYYDKRELLKCGIGHHKITCEGYGAaPNAEQV
|| ||..    |. | | .| .|||||....||...| .||  . |.   .   ....|||||||.| |||.|.|| . |. ..|..| |    |. | |
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeekrftpkdLleklqe.knkklGLvidltntdryykkkeltdegvkylklncpGhev.pkeelv

KEFQTLCVNFF--KDHPDDIIGVHCTHGFNRTGFLIVSYLIDVECWDLESAVATFSMARPPGIYKEHYLHELAGR
|.|.    .|   ... | .|||||||| ||||.||  |||||| .. | |. .|. ||   . .|.||..|  .
kkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkl
mRNA_cap_C mRNA capping enzyme, C-terminal domain 464-565 9.7e-28 86.0 Pfam-A 1-105 (105) alignment 
Range on Protein: 464-565
Range on HMM: 1-105/105.0
ELNTVDFRLNIISEQKVGMLQEKKAQL-LVGsGRHTvLF--SYLDLHVNKEAKAHNNKIIECSFV--DKKWKFLRVRTDKSFPNSFETARSVCMSISQPV
|||||||.|..  |.. |.|.|.| .| .|  |..   |  .    ..... |  ..||.||..   ...|||||.|.||| |||..||..|. ||...|
elntvDfllklekeeedglLeeekgkldyve.ggsd.efitakekeklksdekelkgkIvEcklddkkgrWkflriRkDKsepNsistaekvlksiednv

TKQWLLE
||. |||
tkeeLle
0036282 (Phosphotyrosine protein) phosphatases II 17-174 1e-21 72.8 In-house 12-162 (174) alignment 
Range on Protein: 17-174
Range on HMM: 12-162/174.0
GKVIAGKFFPFKTPLSseydkDLAEGNRFPLSMLIAFTECIPgHRMGLVIDLTKTSRYYdkreLLKCGIGHHKITCEGYGAAPNAEqVKEFQTLCVNFFK
. .| .... .. ||.     ....  .. ..... ..|...   ....|... . |..    | . || .... ....|. . .. . ||  .. ....
lsyitprliagqgpla.....fwemlkelgittvvmlleeke.lglykcinywpelred....lerlgiqylylpwpDhgvpdlsi.llefvkfveeals

DHPDDIIGVHCTHGFNRTGFLIVSYLIDVECW-DLESAVATFSMAR---PPGIYKEHYLHEL
..|.  . |||..|..|||.|.. ||. .  . .|. |.... ..|   |.... ..... |
edpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfl
0041856 (Phosphotyrosine protein) phosphatases II 50-168 1.6e-20 68.9 In-house 47-157 (182) alignment 
Range on Protein: 50-168
Range on HMM: 47-157/182.0
LIAFTECIPGHRMGLVIDLTktSRYYDKRELLKCGIGHHKITCEGYGAAPnAEQVKEFQTLCVNffkdhPDDIIGVHCTHGFNRTGFLIVSYLIDVECWD
. .| . . ... .....||  ...|.  .| . || .... ....|. .  ... .|   . .     ..  . |||..| .|||.|.. ||. .  ..
vadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklgvs

LESAVATFSMARPPGIYKE
||.||... ..|| ..  .
leeavklvrsrRpgmvitp
0043147 (Phosphotyrosine protein) phosphatases II 55-174 3.5e-20 67.9 In-house 38-153 (172) alignment 
Range on Protein: 55-174
Range on HMM: 38-153/172.0
ECIPGHRMGLVIDLTktSRYYDKRELLKCGIGHHKITCEGYGAApNAEQVKEFQTLCVNFFKDHPDDIIGVHCTHGFNRTGFLIVSYLIDvECWDLESAV
. .  .  .....||  ...||.  | . || .. . .. .|.  ..|.. ||  .. ...   |.  . |||..|..|||.|.. ||.  ....|| ||
rmlkelgithivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeav

ATFSMARPPGIYKEHYLHEL
|.. ..|| ... ..... |
alvrekRpgavqnpsqyrfl
0044763 (Phosphotyrosine protein) phosphatases II 55-174 8.4e-19 63.3 In-house 42-163 (178) alignment 
Range on Protein: 55-174
Range on HMM: 42-163/178.0
ECIPGHRMGLVIDLTKTSRYY----DKRELLKCGIGHHKITCEGYGAAPNAEQVKEFQTLCVNFFKdHPDDIIGVHCTHGFNRTGFLIVSYLIDVECWDL
| .  .  .....||.. ...    |.  . . || ...| ....|. .  |.. ||  .. .. .  ..  . |||..|..|.| |.. ||. .  ..|
ellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkklglsl

ESAVATFSMARPpGIYKEHYLHEL
|.|.. . ..|| ... ...|. |
eeaielvrerRp.ivpnpgqlrqL
0040439 (Phosphotyrosine protein) phosphatases II 28-172 2.5e-18 62.0 In-house 60-236 (249) alignment 
Range on Protein: 28-172
Range on HMM: 60-236/249.0
KTPLSSeydkdlaegnrfplsMLIAFTECIPGHRMGLVIDLTKTSRY-------------------------------------------YDKRELLKCG
..||..               .. .| . .  .. . ...||.. ..                                           ||. ..   .
qgPlpe...............tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlh

IGHHKITceGYGAAPNAEQVKEFQTLCVNFFKDH-PDDIIGVHCTHGFNRTGFLIVSYLI-----DVECWDLESAVATFSMARPPGIYKEHYLH
| ....    .|. |. |.. .|  .. .....  ..  . |||..| .|||..|. ||.        ..|||.||... ..|| ... .... 
iqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr
0049260 (Phosphotyrosine protein) phosphatases II 63-174 4.8e-18 60.8 In-house 33-142 (152) alignment 
Range on Protein: 63-174
Range on HMM: 33-142/152.0
GLVIDLTKTSRYYDKRELLKCGIGHHKITCEGYGaAPNAEQVKEFQTLCVNFFKDHPDDIIGVHCTHGFNRTGFLIVSYLIDvECWDLESAVATFSMARP
|  . .. |........  . .| .. . .. .| .|. .|. .|  | ..... ...  . |||..|..|||.|.. ||.    ..|| ||| . ..||
gittivmltellelgklkceqyiqylhlpwpDhg.vpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRp

PGIYKEHYLHEL
 ... ...|  |
gavpnpgqlrfl
0037934 (Phosphotyrosine protein) phosphatases II 49-171 5.6e-18 60.8 In-house 60-231 (243) alignment 
Range on Protein: 49-171
Range on HMM: 60-231/243.0
MLIAFTECIPGHRMGLVIDLTKTS----------------------------------------RYYDKRELLKCGIGHHKITCEGYGAAPNAEQVKEFQ
.| .| . .  .. . ...||..                                         ...|  .| . .| .| .   ..|. .. |.. .| 
dlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfl

TLCVNFFKD-------HPDDIIGVHCTHGFNRTGFLIVSYLIDVE-CWDLESAVATFSMARPP-GIYKEHYL
  . .| ..       ...  . |||..| .||| ||. ||.    ..|||.||... . ||  ..  ....
devrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy
0040438 (Phosphotyrosine protein) phosphatases II 50-170 6.7e-18 60.4 In-house 99-264 (317) alignment 
Range on Protein: 50-170
Range on HMM: 99-264/317.0
LIAFTECIPGHRMGLVIDLTKTSRYYD----------------------KRELLKCGIGHHKITC-------------------EGYGAAPNAEQVKEFQ
.  | ...  .. .... ||..  . .                      . |  . || ......                     .|. |. ... .| 
vedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfl

TLCVNFFKdHPDDIIGVHCTHGFNRTGFLIVSYLI-----DVECWDLESAVATFSMARPPGIYKEHY
 .. .... .|.  . |||..| .|||..|. ||.       ...|.|.||... ..|| ... . .
eavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeq
0048179 (Phosphotyrosine protein) phosphatases II 60-174 1e-17 59.6 In-house 28-137 (144) alignment 
Range on Protein: 60-174
Range on HMM: 28-137/144.0
HRMGLVIDLTKTsryYDKRELLKCGIGHHKITCEGYGAAPNAEQVKEFQTLCVNFFKdhPDDIIGVHCTHGFNRTGFLIVSYLIDVECWDLESAVATFSM
.  ..||.|| .   |.. .| . || .... ....|. . .|.. ||  .. .. .  ..  . |||..|..|||.|.. ||. .. ..||.|.| . .
lgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrs

ARPPGIYKEHYLHEL
.|| ... ...|. |
rrpgavpnpgqlrfL
0048076 (Phosphotyrosine protein) phosphatases II 60-174 1.3e-17 59.3 In-house 28-135 (145) alignment 
Range on Protein: 60-174
Range on HMM: 28-135/145.0
HRMGLVIDLtktsrYYDKRELLKCGIGHHKITCEGYGAAPNAEQVKEFQTLCVNFFKDHpdDIIGVHCTHGFNRTGFLIVSYLIDVECWDLESAVATFSM
.  ..|..|      .... | . || .. . ....|. . .|.. ||  .. .. |..    . |||..| .|||.|.. ||.  . ..||.|.. . .
lgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrs

ARPPGIYKEHYLHEL
.|| ... ...|. |
qrpgavpnpgqlrfl
0049772 (Phosphotyrosine protein) phosphatases II 61-162 2.4e-17 59.1 In-house 167-255 (314) alignment 
Range on Protein: 61-162
Range on HMM: 167-255/314.0
RmglvidltktSRYYDKRELLKCGIGHHKITCEGyGAAPNAEQVKEFQTLCVNFfkdHPDDIIGVHCTHGFNRTG-FLIVSYLIDVECWDLESAVATFSM
.          ...||.  . . || .. | ... | ||  |...||  .. ..   ...  . |||..| .||| |... ||.    ..|| |.. . .
k..........eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrl

ARP
.||
kRp
0042113 (Phosphotyrosine protein) phosphatases II 53-171 4.3e-17 57.8 In-house 68-232 (245) alignment 
Range on Protein: 53-171
Range on HMM: 68-232/245.0
FTECIPGHRMGLVIDLTKTSRYYD-----------------------------------------KRELLKCGIGHHKITCEGYGAAPNAEQVKEFQTLC
| . .  ..   ...||..  .                                           .    . .| .| . ....|.... |.. .|  ..
fwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefv

VNFFKDHPDDIIGVHCTHGFNRTGFLIVSYLI-----DVECWDLESAVATFSMARPPGIYKEHYL
 .. .....  . |||..| .||| .|. ||.        ...||.||. . . ||  .  ....
rkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqy
PTEN_1 61-179 8.1e-16 53.4 In-house 67-189 (196) alignment 
Range on Protein: 61-179
Range on HMM: 67-189/196.0
RMGLVIDLTKTS----RYYDKRELLKCGIGHHKITCEGYGAaPNAEQVKEFQTLCVNFFKDHP-DDIIGVHCTHGFNRTGFLIVSYLIDVECWDLESAVA
   ||..|.  .    | ||..|  | |. ....  | .|| |. ... ..   . .  . .|   .. |||..| .|.|... .||.  . .. . |..
gitlvvnlseeeelsgrsydleeffksgveylhfpieDhga.pslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAle

TFSMARPPGIYKEHYLHELAGRYA
 .  .||||     .. .|   .|
lvrekRppgapnspsqerlleyfa
0045450 (Phosphotyrosine protein) phosphatases II 50-171 3.4e-15 52.0 In-house 120-293 (307) alignment 
Range on Protein: 50-171
Range on HMM: 120-293/307.0
LIAFTECIPGHRMGLVIDLTKTSR--------YYDKR--------------------------------ELLKCGIGHHKITC---EGYGAAPNAEQVKE
.  | . .  .. .....||..          |.                                   .  . .. .. . .    ..|. |. |.. .
vedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelld

FQTLCVNFFKDH-PDDIIGVHCTHGFNRTGFLIVSYLIDVEC--------WDLESAVATFSMARPPGIYKEHYL
|  .. ...... ..  . |||..| .||| .|. ||. .          .||..||... . || ..  ....
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy
0046846 (Phosphotyrosine protein) phosphatases II 50-165 8.8e-15 50.4 In-house 36-156 (176) alignment 
Range on Protein: 50-165
Range on HMM: 36-156/176.0
LIAFTECIPGHRMGLVIDLTKT------SRYYDKRELLKCGIGHHKITCEGYGAAPNaEQVKEFQTLCVNFFKDHpdDIIGVHCTHGFNRTGFLIVSYLI
| .| | .  .. ..|..||.       . ...  || | || .. .  . .|. .  |.. |.  .. .. |..    . ||| .| .||| |.. ||.
ladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayll

DV-ECWDLESAVATFSMARP-PGI
    ....| |.|.. . ||   .
elekglsveealalvreqRplgav
0051082 (Phosphotyrosine protein) phosphatases II 56-165 1.1e-14 49.8 In-house 28-136 (151) alignment 
Range on Protein: 56-165
Range on HMM: 28-136/151.0
CIPGHRMGLVIDLTKTS-RYYDKRELLKCGIGHHKITCEGYGAAPnAEQVKEFQTLCVNFFKDHPDDIIGVHCTHGFNRTGFLIVSYLIDvECWDLESAV
 .  .    ...|...  |.|... | . || .. | ...  . .  ..  ..    .... |...  . |||..| .|||.|.. ||.  . ..||.|.
llkelgiktivnlrseeergycpeylpelgievlhipildwpdpg.lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleeal

ATFSMARPPGI
. . . ||  .
eeyrlkrpgvv
0043336 (Phosphotyrosine protein) phosphatases II 52-169 3.5e-14 48.4 In-house 103-264 (278) alignment 
Range on Protein: 52-169
Range on HMM: 103-264/278.0
AFTECIPGHRMGLVIDLTKTSRY------------------------------------------YDKREllKCGIGHHKITCEGYGAAPNAEQVKEFQT
 | . .  ..   ...||.   .                                          .|. .  . . ..| .    .|. .. ... .|  
dFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhylgwpdhgvpeslsllldflk

LCVNFFKdHPDDIIGVHCTHGFNRTGFLIVSYLI-----DVECWDLESAVATFSMARPPGIYKEH
   .... ...  . |||..| .||| .|. ||.     .  ..|||.||... . ||  .  . 
avreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtps
0039614 (Phosphotyrosine protein) phosphatases II 53-171 9.3e-14 47.0 In-house 117-278 (297) alignment 
Range on Protein: 53-171
Range on HMM: 117-278/297.0
FTECIPGHRMGLVIDLTKTSRY--------------------YDKRELLKCGIG-----------------HHKITCEGYGAAPNAEQVKEFQTLCVNFF
| . .  ..   .. |||.  .                    . ...  . |.                  .. .    .|. |..|.. ||  |. ...
FwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreal

KDH-PDDIIGVHCTHGFNRTGFLIVSYLI-----DVECWDLESAVATFSMARPPGIYKEHYL
.   ..  . |||..| .||| .|. ||.        ..|...||... ..|| ..  ....
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy
0045098 (Phosphotyrosine protein) phosphatases II 50-169 4e-13 44.9 In-house 77-259 (278) alignment 
Range on Protein: 50-169
Range on HMM: 77-259/278.0
LIAFTECIPGHRMGLVIDLTKT--------------------------------------------SRYYDKRELLKCGIGHHKI-TCEGYGAAPNA--E
. .| ...  ..   .. ||.                                               .. . .| . |. |... . . .|. ..    
vadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilk

QVKEFQTLCVNFFK------------DHPDDIIGVHCTHGFNRTGFLIVSYLIDVE---CWDLESAVATFSMARPP-GIYKEH
.. |.   . .. |            . ..  . ||| .| .||| |.. ||.       .||..||... . ||   .  ..
sflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnle
0046845 (Phosphotyrosine protein) phosphatases II 86-168 8.7e-11 37.2 In-house 169-260 (284) alignment 
Range on Protein: 86-168
Range on HMM: 169-260/284.0
GHHKITCEGYGAAPNAEQVKEFQTLCVNFFKD-HPDDIIGVHCTHGFNRTGFLIVSYLIDVE--------CWDLESAVATFSMARPPGIYKE
 .| ..   .|. |..|.. ||  |. ..... ...  | ||| .| .||| .|. .|.           ..|...||. . . ||  .  .
hfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
DSPc Dual specificity phosphatase, catalytic domain 121-174 1.4e-10 36.2 Pfam-A 74-127 (133) alignment 
Range on Protein: 121-174
Range on HMM: 74-127/133.0
DIIGVHCTHGFNRTGFLIVSYLIDVECWDLESAVATFSMARpPGIYKE-HYLHEL
  . |||..| .|.. ||. ||.. ....|..|.. ..  | . | .  ..|..|
kkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skispnagflrqL
DSPc Dual specificity phosphatase, catalytic domain 121-174 1.4e-10 36.2 In-house 74-127 (133) alignment 
Range on Protein: 121-174
Range on HMM: 74-127/133.0
DIIGVHCTHGFNRTGFLIVSYLIDVECWDLESAVATFSMARpPGIYKE-HYLHEL
  . |||..| .|.. ||. ||.. ....|..|.. ..  | . | .  ..|..|
kkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skispnagflrqL
subfamily_CDC14_pd Subfamily CDC14 19-165 2.6e-10 34.7 In-house 175-308 (328) alignment 
Range on Protein: 19-165
Range on HMM: 175-308/328.0
VIAGKFFPFKTPLSSEYdkdlaEGNRFPLSMLIAFTECIPGHRMGLVIDLTKTsrYYDKRELLKCGIGHHKITCEGyGAAPNAEQVKEFQTLCVNFfkdh
.. .||  .  | . ..     . ...||    .. |    ...  |. | |    ||...  . |. |. .  .  |. |. . ||.| ... .     
ivPdkflalagPhnksk.....ledgyplhaPeklleyfrknnvttvvrLnkk..lYdakkftdaGfdhkDlffiD.GstPsdaivkkfleiaeka....

pDDIIGVHCTHGFNRTGFLIVSYLIDVECWDLESAVATFSMARPPGI
 .  | |||  |. ||| || .||.       . |.| . ..||  .
.eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsv
0051429 (Phosphotyrosine protein) phosphatases II 62-169 3.8e-10 35.4 In-house 46-212 (272) alignment 
Range on Protein: 62-169
Range on HMM: 46-212/272.0
MGLVIDLTKTSRYY-DKRELLKCGIGHHKITCEGYGAAPNA---------------------------------------------------EQVKEFQT
   ..||.... .  .| ...  || .. . .....| .                                                     |...|.  
iktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallelle

LCVNffkdhpDDIIGVHCTHGFNRTGFLIVSYLIDvECWD--------------LESAVATFSMARPPGIYKEH
|. .      .  . |||..| .|||.... .|.  . ..              || ||.    .||  .  |.
llld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee
0048567 (Phosphotyrosine protein) phosphatases II 95-165 4e-10 34.3 In-house 48-122 (157) alignment 
Range on Protein: 95-165
Range on HMM: 48-122/157.0
YGaAPNAEQVKEFQTLCVNFFK--DHPDDIIGVHCTHGF---NRTGFLIVSYLIDVECWDLESAVATFSMARPPGI
.|  .|  .. .| ..  .|.|  .. .  | |||..|     ||..|| .||| .  .. | |.| ....||. .
fG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsv
0050432 (Phosphotyrosine protein) phosphatases II 88-166 6.5e-10 34.3 In-house 203-283 (308) alignment 
Range on Protein: 88-166
Range on HMM: 203-283/308.0
HKITCEGYGAAPNAEQVKEFQTLCVNFFkdhPDDIIGVHCTHGFNRTGFLIVSYLI-----DVECWDLESAVATFSMARPPGIY
| .... .|. |..|.. .|  |. ...   |.  | ||| .| .||| .|. .|.        ..|...||... . ||  . 
hytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq
0047943 (Phosphotyrosine protein) phosphatases II 88-168 6.9e-10 34.3 In-house 172-258 (273) alignment 
Range on Protein: 88-168
Range on HMM: 172-258/273.0
HKITCEGYGAAPNAEQVKEFQTLCVNFFKDH-PDDIIGVHCTHGFNRTGFLIVSYLI-----DVECWDLESAVATFSMARPPGIYKE
|  .   .|. |. |.. ||  |. ....    .  . ||| .| .||| .|. .|.        ..|...||. . . || ... .
hytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp
PTPc_motif_SM00404 123-174 1.2e-09 33.2 In-house 83-134 (140) alignment 
Range on Protein: 123-174
Range on HMM: 83-134/140.0
IGVHCTHGFNRTGFLIVSYLIDVECWDLESAVATFSMARpPGIYKE-HYLHEL
. |||..| .|.. ||. ||.. . ..|..|.  ..  | | | .  .....|
vlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR.piispnlnfvrqL
0051299 (Phosphotyrosine protein) phosphatases II 77-167 2.1e-09 32.8 In-house 177-271 (288) alignment 
Range on Protein: 77-167
Range on HMM: 177-271/288.0
KRELLKCGIGHHKITCEGYGAAPNAEQVKEFQTLCVNFFKdHPDDIIGVHCTHGFNRTGFLIVSYLI-----DVECWDLESAVATFSMARPPGIYK
. .  .  . .| ..   .|. ...|.. .|  |. .... ...  . ||| .| .||| .|. .|.       ...|...||... . ||  .  
gdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
DNA_ligase_A_M ATP dependent DNA ligase domain 286-461 7.9e-09 24.3 Pfam-A 18-202 (202) alignment 
Range on Protein: 286-461
Range on HMM: 18-202/202.0
EKPYRVSWKADGTRyMLYIKDKGHIYLIDRDNSVFNS--PNITFLSRKREGEHLRDCVADSELVL-DKVDGAVRPRLLIYDIMMFEGS----KDVAKCDH
|... |..| || | .   ||.....|. |    . .  |...   ...  .. .... |.|||. ||  |. .|.  . .  . . .    |..  . .
egafiveeKyDGeR.vqvhkdgdevkllSRrgkditakkpellkalkeaflkdvksvildGElvavdketgeilpfqtlasrknkkkvkveekeaelsff

QRRMLCIDRELIMPREEAAKRGIIDKIR--EPFSVRAKQFWDVSESRMILESYVPKLTHENDGLIYNPTNQPYKPGQC-QDLLKWK
   .|..| | .....   .| ....|   ..  .   .  .|...  . | .  .. .. .|..   .. .|.||.  ...|| |
vFDvlyldgesltdepleeRrklLeeifkesenrieiaetlevndveeleelleevikeglEGvvlKdpdskYepgkrssnwlKlK
subfamily_PRL_pd Subfamily PRL 74-154 1.4e-08 29.0 In-house 45-123 (151) alignment 
Range on Protein: 74-154
Range on HMM: 45-123/151.0
YYDKRELLKCGIGHHKITCEGyGAAPNAEQVKEFQTLCVNFFKDHPDDIIGVHCTHGFNRTGFLIVSYLIDVEcWDLESAV
 ||...| | ||  . .. .  ||.|  | |.|. .|. . ||..|. ...|||  |. |.  |..  ||.    . | ||
tydteklekegievldlafdd.GavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaG.mkyedav
0036941 (Phosphotyrosine protein) phosphatases II 92-166 1.9e-08 29.4 In-house 178-261 (297) alignment 
Range on Protein: 92-166
Range on HMM: 178-261/297.0
CEGYGAAPNAEQVKEFQTLCVNFFKDH-PDDIIGVHCTHGFNRTGFLIVSYLI--------DVECWDLESAVATFSMARPPGIY
   .|. ...... .|  |. .. |   ..  . ||| .| .|.| .|. .|.          ...|. .|| .. . ||  . 
wpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq
subfamily_DSP23_pd Subfamily DSP23 84-165 5.7e-08 27.5 In-house 51-129 (148) alignment 
Range on Protein: 84-165
Range on HMM: 51-129/148.0
GIGHHKITCEGYgAAPNAEQVKEFQTLCVNffKDHPDDIIGVHCTHGFNRTGFLIVSYLIDVECWDLESAVATFSMARPPGI
..  ...  . |   |  |||.||  .  .   .. .. ..|||  |. ||| ..  ||.  .      |.|     ||  .
nltlvrlriddy.hppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsv
subfamily_PTEN_pd Subfamily PTEN 73-161 7.9e-08 27.5 In-house 71-156 (184) alignment 
Range on Protein: 73-161
Range on HMM: 71-156/184.0
RYYDKRELlKCGIGHHKITcegYGAAPNAEQVKEFQTLCVNFFKDHPDDIIGVHCTHGFNRTGFLIVSYLIDVECWDLE-SAVATFSMAR
|.||.... .. . . ...      .|. | ..|. .   ....  .. .. |||  |  ||| |||.||.    .. . .|.. |. ||
rkydskkf.dgrvavypfd...DhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
subfamily_PTPDC1_pd Subfamily PTPDC1 75-169 7.9e-08 26.9 In-house 73-163 (182) alignment 
Range on Protein: 75-169
Range on HMM: 73-163/182.0
YDKRELLKCGIGHHKITCEGYGAAPNaEQVKEFQTLcVNFFKDHPddIIGVHCTHGFNRTGFLIVSYLIDVECWDLESAVATFSMARPPGIYKEH
||. .| . || ..... . ||.|.  |.. .   . |.|  ..    ..|||  |  ||| || .||. ..  . | |. .    ||  |.  .
YdlealmeqgiyvynfgwkDygvasl.eriLdivkv.vafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtre
subfamily_VSP_pd Subfamily VSP 98-149 9.9e-06 19.6 In-house 106-157 (212) alignment 
Range on Protein: 98-149
Range on HMM: 106-157/212.0
APNAEQVKEFQTLCVNFFKDHPDDIIGVHCTHGFNRTGFLIVSYLIDVECWD
 |. |..  |     ..... ..... .||  | .||| .. ..|.  | ..
vpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseife