Gene RNGTT-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily RNGTT
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP016_AA protein Get Run
AqueP016_AA_48-197 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_RNGTT_pd Subfamily RNGTT 41-213 7e-78 254.7 In-house 1-188 (189) alignment
Range on Protein: 41-213
Range on HMM: 1-188/189.0
PRSWRHCPKEGSLIANKFLPFKTPLSSQYDKDLSEKERFPPSVLTSYRDT--YRIGLVIDLTNTSRYYDKREL---------LQCA-----PDVEKVKEF
|..|..||..|.|||.||||||||||..||.||.|..||.||.|.|| .|  ...|||||||||||||||.||         ||||     |. |.||||
PerWlnCPrkgkliaekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkef

QMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGIYKEHYLHELAGRYADGdIGSIITPPLPDWCD
.... ||||..|. |.|||||||||||||||||||...|.|..|||||.|. |||||||||.||.||. ||||    .| .| ||||| 
iklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadv.eeaiaapelpdwcl

mRNA_cap_enzyme mRNA capping enzyme, catalytic domain 262-451 1.8e-54 173.6 Pfam-A 1-192 (192) alignment
Range on Protein: 262-451
Range on HMM: 1-192/192.0
QPVSMDVQNIRFLNEKPYRVSWKADGTRYMLYIKGKgQIYLIDRDNSVFNSPNITFLSRKR--EGEHLRDCVADSELVLDKVDGAVRPRLLIYDIMMFEG
||||.. .|...|..|.| ||.||||.|..|.|. | ..|||||||.|.  .|..|  ...  . ... . . | |||.|.| .  ..| |||||....|
qpvslsrenlkllkqkdYyvseKaDGlRvlllitkk.evylidrdnevylvenlkfplklekekekvhhgtllDGElvidtveeeqklryliyDilaing

SKdVARCDHQRRMLCIDRELIMPREEA-AKRGIIDKIREPFSVRAKQFWDVSESRM-ILEKYAPTLTHENDGLIYNPTNEPYKPGQCKDLLIWK
   |. .. . |. .. .|.| ||.|. .| .||..  |||.|| |.|.. . ..  . .| ...| ||.||||. ....||..|..|.|| ||
el.vserplskRleilkkeiikpraeeklkthiiktelepfkvrlksfilllalekllskkkikklsheiDGLIfqsvdtpYvagrdknllKWK

0038934 (Phosphotyrosine protein) phosphatases II 40-197 2.9e-43 143.1 In-house 2-175 (194) alignment
Range on Protein: 40-197
Range on HMM: 2-175/194.0
IPRSWRHCPKEGSLIANKFLPFKTPLSSQYDKDLSEKERFPPSVLTSYRDTY--RIGLVIDLTNTSRYYDKRELLQ--------------CAPDVEKVKE
.|  |..... |..| ..|..||.|||. .|| ..|  ||.|. | .| ...  ..|||||||||.||||..|. .              ..|. | ...
lPdrwlkyervgdiitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillr

FQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGIYKEHYLHELAGRYAD
|  .. ||....| |||.|||..|..|||.|...||| . ....|.|.|.|. .||..|.. .||..|  || .
fldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryke

subfamily_DSP11_pd Subfamily DSP11 40-194 6.5e-33 108.1 In-house 1-173 (178) alignment
Range on Protein: 40-194
Range on HMM: 1-173/178.0
IPRSWRHCPKEGS-LIANKFLPFKTPLSSQYDKDLSEKERFPPSVLTSYRD--TYRIGLVIDLTNTSRYYDKRELLQC-------------APDVEKVKE
.|  |..  . |. .  ..|..|||||....||...|..|| |. | .  .   ...||||||||| |||.|.|| .               |. | ||.
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkk

FQMVCGEFF--KDHPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGIYKEHYLHELAGR
|. .  ||   ...   ..||||||| ||||.||  |||||| .. | |. .|. ||   . .|.||..|  .
fkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkl

0036282 (Phosphotyrosine protein) phosphatases II 48-191 7.4e-19 63.5 In-house 9-162 (174) alignment
Range on Protein: 48-191
Range on HMM: 9-162/174.0
PKEGSLIANKFLPFKTPLSsqydkDLSEKERFPPSVLTSYRDTYRIG--LVIDLTNTSRYYDKRELLQ---------CAPDVEKVKEFQMVCGEFFKDHP
|  .| | .... .. ||.     .. .  ..  ... .... .  |  ..|..... |.. .|. .|         ..||.... ||   . |.....|
pldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedp

YGVVGVHCTHGFNRTGFLIVSYLIDVECW-DLEAAVATFSVAR---PPGIYKEHYLHEL
 |.| |||..|..|||.|.. ||. .  . .|. |....  .|   |.... ..... |
ggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfl

mRNA_cap_C mRNA capping enzyme, C-terminal domain 455-542 7.9e-17 51.0 Pfam-A 5-98 (105) alignment
Range on Protein: 455-542
Range on HMM: 5-98/105.0
VNFHLNIITEKKFGMLEEKKAQL-LV-GSERcEKIFSYLDLQVNKDAKKHSKKIIECSFVN--NKWKFLRVRTDKGFPDSIETAKSICI---DSV
| | |.. .|.. |.|||.| .| .| |    |.| .    ....| |. . ||.||.. .  ..|||||.|.||  | ||.||....    | |
vDfllklekeeedglLeeekgkldyveggsd.efitakekeklksdekelkgkIvEcklddkkgrWkflriRkDKsepNsistaekvlksiednv

0041856 (Phosphotyrosine protein) phosphatases II 90-185 1.7e-15 52.6 In-house 56-157 (182) alignment
Range on Protein: 90-185
Range on HMM: 56-157/182.0
TYRIGLVIDLTntSRYYDKRELLQ-------------CAPDVEKVKEFQMVCGEffkdhPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSV
 ..|.....||  ...|.  .| .             ..||.... .|   . |     . |.| |||..| .|||.|.. ||. .  ..|| ||...  
elgittivnlt..eelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrs

ARPPGIYKE
.|| ..  .
rRpgmvitp

0040439 (Phosphotyrosine protein) phosphatases II 30-189 2.5e-15 52.2 In-house 13-236 (249) alignment
Range on Protein: 30-189
Range on HMM: 13-236/249.0
SRRRSVHTQSIPRSWRHCPK---------------EGSLIANKFLPFKTPLSSqydkdlsekerfppsvlT-----SYRDTYRIGLVIDLTNTSRY----
...|...    ..|. .                  .|. | ..|. ...||..                 |      .   ..|. ...||.. ..    
dknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe.................tvedfwrmlwelgitvivmLtslvelgrek

---------------------------------------YDKREL------------LQCAPDVEKVKEFQMVCGEFFKDH-PYGVVGVHCTHGFNRTGF
                                       ||. ..             .. |..| . .|   . .....  . |.| |||..| .|||.
caqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

LIVSYLI-----DVECWDLEAAVATFSVARPPGIYKEHYLH
.|. ||.        ..||| ||...  .|| ... .... 
fiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr

0043147 (Phosphotyrosine protein) phosphatases II 80-191 3.8e-15 51.5 In-house 32-153 (172) alignment
Range on Protein: 80-191
Range on HMM: 32-153/172.0
PPSVLTSYRDTYRIGLVIDLTNTsrYYDKRELL-------------QCAPDVEKVKEFQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDvECWD
. .    .  .. |.....||.   .||.  |              ...|. | . ||   . |..   | |.| |||..|..|||.|.. ||.  ....
tladfwrmlkelgithivnltel..lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lgls

LEAAVATFSVARPPGIYKEHYLHEL
|| |||..  .|| ... ..... |
leeavalvrekRpgavqnpsqyrfl

0044763 (Phosphotyrosine protein) phosphatases II 88-191 5.1e-15 51.0 In-house 44-163 (178) alignment
Range on Protein: 88-191
Range on HMM: 44-163/178.0
RDTYRIGLVIDLTNTSRYYDKRELL-----------------QCAPD-VEKVKEFQMVCGEFFK-DHpyGVVGVHCTHGFNRTGFLIVSYLIDVECWDLE
   . |.....||.. ...   ..                   ..||  | . ||   . |. . ..  |.| |||..|..|.| |.. ||. .  ..||
lkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkklglsle

AAVATFSVARPpGIYKEHYLHEL
.|.. .  .|| ... ...|. |
eaielvrerRp.ivpnpgqlrqL

0049260 (Phosphotyrosine protein) phosphatases II 113-191 6.8e-15 50.5 In-house 65-142 (152) alignment
Range on Protein: 113-191
Range on HMM: 65-142/152.0
QCAPDVEKVKEFQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDvECWDLEAAVATFSVARPPGIYKEHYLHEL
 ..|| . . .| .   |... .. |.| |||..|..|||.|.. ||.    ..|| ||| .  .|| ... ...|  |
hgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrfl

0048076 (Phosphotyrosine protein) phosphatases II 90-191 2.4e-14 48.7 In-house 27-135 (145) alignment
Range on Protein: 90-191
Range on HMM: 27-135/145.0
TYRIGLVIDLTNTSRYYDKRELL--------QCAPDV-EKVKEFQMVCGEFFKDHpyGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPP
 . |..|..||.. ... .  .          ..||  | . ||   . |. |..  |.| |||..| .|||.|.. ||.  . ..|| |.. .  .|| 
dlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpg

GIYKEHYLHEL
... ...|. |
avpnpgqlrfl

PTEN_1 115-196 2.8e-14 48.4 In-house 107-189 (196) alignment
Range on Protein: 115-196
Range on HMM: 107-189/196.0
APDVEKVKEFQMVCGEFFKDHP-YGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGIYKEHYLHELAGRYA
||. ... ..  .. |  . .|  .|| |||..| .|.|... .||.  . .. . |.. .  .||||     .. .|   .|
apslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfa

0048179 (Phosphotyrosine protein) phosphatases II 91-191 3e-14 48.5 In-house 28-137 (144) alignment
Range on Protein: 91-191
Range on HMM: 28-137/144.0
YRIGLVIDLTNTsRYYDKRELL-----------QCAPDV-EKVKEFQMVCGEFFKDHpyGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVAR
. |..||.||.. ....  |              ..||  | . ||   . |. ...  |.| |||..|..|||.|.. ||. .. ..|| |.| .  .|
lgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrr

PPGIYKEHYLHEL
| ... ...|. |
pgavpnpgqlrfL

0040438 (Phosphotyrosine protein) phosphatases II 91-187 5.3e-14 47.7 In-house 109-264 (317) alignment
Range on Protein: 91-187
Range on HMM: 109-264/317.0
YRIGLVIDLTNTSRY--------YDKRE----------------------------------------------LLQCAP-DVEKVKEFQMVCGEFFKdH
....... ||..  .        .  .|                                                ...| . . . .|   . |... .
qgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.d

PYGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYKEHY
| |.| |||..| .|||..|. ||.       ...|.| ||...  .|| ... . .
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeq

0045450 (Phosphotyrosine protein) phosphatases II 91-188 6.7e-14 47.8 In-house 130-293 (307) alignment
Range on Protein: 91-188
Range on HMM: 130-293/307.0
YRIGLVIDLTNTS--------RYYDKR-------------------------------------------------ELLQCAPDVEKVKEFQMVCGEFFK
........||..         .|.                                                       .. |..| . .|   . ....
qgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkale

DH-PYGVVGVHCTHGFNRTGFLIVSYLIDVEC--------WDLEAAVATFSVARPPGIYKEHYL
.. . |.| |||..| .||| .|. ||. .          .||. ||...   || ..  ....
elpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

0042113 (Phosphotyrosine protein) phosphatases II 55-188 1.7e-13 46.0 In-house 51-232 (245) alignment
Range on Protein: 55-188
Range on HMM: 51-232/245.0
ANKFLPFKTPLSSqydkdlsekerfppsvL----TSYRDTYRIGLVIDLTNTSR---------------------------------------------Y
 .||. .  ||..                       .   ..|  ...||..                                               .
tpkfiatqgPlpe................tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgd

YDKRELLQ---------CAPD-VEKVKEFQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYKEHYL
. .|| ..         ..|| .| . .|   . .. .... |.| |||..| .||| .|. ||.        ...|| ||. .   ||  .  ....
desrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqy

0037934 (Phosphotyrosine protein) phosphatases II 91-188 5.5e-13 44.5 In-house 71-231 (243) alignment
Range on Protein: 91-188
Range on HMM: 71-231/243.0
YRIGLVIDLTNTS--------------------------------------------RYYDKRELLQ---------CAPD-VEKVKEFQMVCGEFFKD--
..|. ...||..                                              .. .|.  .         ..|| .| . .|   . || ..  
lgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieell

-----HPYGVVGVHCTHGFNRTGFLIVSYLIDVE-CWDLEAAVATFSVARPP-GIYKEHYL
     .. |.| |||..| .||| ||. ||.    ..||| ||...   ||  ..  ....
sllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy

0049772 (Phosphotyrosine protein) phosphatases II 114-179 6.2e-13 44.6 In-house 192-255 (314) alignment
Range on Protein: 114-179
Range on HMM: 192-255/314.0
CAPDVEKVKEFQMVCGEFfkdHPYGVVGVHCTHGFNRTG-FLIVSYLIDVECWDLEAAVATFSVARP
.||. | ..||  .. |.   .. |.| |||..| .||| |... ||.    ..|| |.. .  .||
saplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp

0051082 (Phosphotyrosine protein) phosphatases II 90-182 1.6e-12 42.8 In-house 31-136 (151) alignment
Range on Protein: 90-182
Range on HMM: 31-136/151.0
TYRIGLVIDLTNTSRYY--------------DKRELLQCAPDVEKVKEFQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDvECWDLEAAVATFS
.. |  ...|...  ..              .   |  ..|...   .. .   |.. |.. |.| |||..| .|||.|.. ||.  . ..||.|.. . 
elgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyr

VARPPGI
  ||  .
lkrpgvv

0039614 (Phosphotyrosine protein) phosphatases II 92-188 2.4e-12 42.4 In-house 125-278 (297) alignment
Range on Protein: 92-188
Range on HMM: 125-278/297.0
RIGLVIDLTNTSRY---------------------------------------------------YDKRELLQCAPDVEKVKEFQMVCGEFFKDH-PYGV
..  .. ||..  .                                                   | .    .. |..| . ||   . |...   . |.
gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggp

VGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYKEHYL
| |||..| .||| .|. ||.        ..|.. ||...  .|| ..  ....
vlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy

0043336 (Phosphotyrosine protein) phosphatases II 113-185 1.1e-11 40.2 In-house 186-263 (278) alignment
Range on Protein: 113-185
Range on HMM: 186-263/278.0
QCAP-DVEKVKEFQMVCGEFFKdHPYGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYKE
...| ... . .|  .  |... .. |.| |||..| .||| .|. ||.     .  ..||| ||...   ||  .  .
hgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp

0046846 (Phosphotyrosine protein) phosphatases II 92-182 4.4e-11 38.3 In-house 47-156 (176) alignment
Range on Protein: 92-182
Range on HMM: 47-156/176.0
RIGLVIDLTNTS--------RYYDK-----------RELLQCAPDVEKVKEFQMVCGEFFKDHpyGVVGVHCTHGFNRTGFLIVSYLIDV-ECWDLEAAV
.|..|..||.          .|..                 ..|| | . |.   . |. |..  |.| ||| .| .||| |.. ||.    ....| |.
gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveeal

ATFSVARP-PGI
|..   ||   .
alvreqRplgav

DSPc Dual specificity phosphatase, catalytic domain 138-191 2.5e-10 35.4 Pfam-A 74-127 (133) alignment
Range on Protein: 138-191
Range on HMM: 74-127/133.0
GVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARpPGIYKE-HYLHEL
. | |||..| .|.. ||. ||.. ....|. |.. ..  | . | .  ..|..|
kkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skispnagflrqL

DSPc Dual specificity phosphatase, catalytic domain 138-191 2.5e-10 35.4 In-house 74-127 (133) alignment
Range on Protein: 138-191
Range on HMM: 74-127/133.0
GVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARpPGIYKE-HYLHEL
. | |||..| .|.. ||. ||.. ....|. |.. ..  | . | .  ..|..|
kkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skispnagflrqL

PTPc_motif_SM00404 138-191 2.5e-10 35.4 In-house 81-134 (140) alignment
Range on Protein: 138-191
Range on HMM: 81-134/140.0
GVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARpPGIYKE-HYLHEL
| | |||..| .|.. ||. ||.. . ..|..|.  ... | | | .  .....|
gkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR.piispnlnfvrqL

0045098 (Phosphotyrosine protein) phosphatases II 115-186 4.5e-10 34.9 In-house 169-259 (278) alignment
Range on Protein: 115-186
Range on HMM: 169-259/278.0
APDVEKVKEFQMVCGEFFK---------------DHPYGVVGVHCTHGFNRTGFLIVSYLIDVE---CWDLEAAVATFSVARPP-GIYKEH
.|. . .| |. .. .  .               . . |.| ||| .| .||| |.. ||.       .||. ||...   ||   .  ..
vpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnle

0046845 (Phosphotyrosine protein) phosphatases II 114-185 1e-09 33.7 In-house 179-260 (284) alignment
Range on Protein: 114-185
Range on HMM: 179-260/284.0
CA-PDVEKVKEFQMVCGEFFKD-HPYGVVGVHCTHGFNRTGFLIVSYLIDVE--------CWDLEAAVATFSVARPPGIYKE
.. |..| . ||   . |.... .. |.. ||| .| .||| .|. .|.           ..|.. ||. .   ||  .  .
gvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl

0047943 (Phosphotyrosine protein) phosphatases II 116-185 5.7e-09 31.3 In-house 183-258 (273) alignment
Range on Protein: 116-185
Range on HMM: 183-258/273.0
PDVEKVKEFQMVCGEFFKDH-PYGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYKE
|..| . || ... ....     |.| ||| .| .||| .|. .|.        ..|.. ||. .   || ... .
pslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp

0051429 (Phosphotyrosine protein) phosphatases II 90-186 1.2e-08 30.4 In-house 43-212 (272) alignment
Range on Protein: 90-186
Range on HMM: 43-212/272.0
TYRIGLVIDLTNTSRYYDKR-ELLQ-------------CAPDV----------------------------------------------------EKVKE
...|  ..||.... .     ...              .||..                                                    | ..|
elgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqealle

FQMVCGEffkdhpYGVVGVHCTHGFNRTGFLIVSYLIDvECWD--------------LEAAVATFSVARPPGIYKEH
.  .. .       | | |||..| .|||.... .|.  . ..              ||.||.    .||  .  |.
llellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee

0048567 (Phosphotyrosine protein) phosphatases II 117-182 1.6e-08 29.1 In-house 52-122 (157) alignment
Range on Protein: 117-182
Range on HMM: 52-122/157.0
DVEKVKEFQMVCGEFFK--DHPYGVVGVHCTHGF---NRTGFLIVSYLIDVECWDLEAAVATFSVARPPGI
..  . .| ..  .|.|  ..  ... |||..|     ||..|| .||| .  .. | |.| ....||. .
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsv

0050432 (Phosphotyrosine protein) phosphatases II 115-183 3.2e-08 28.7 In-house 213-283 (308) alignment
Range on Protein: 115-183
Range on HMM: 213-283/308.0
APDVEKVKEFQMVCGEFFKDhpyGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIY
 |..| . .|   . .....   |.. ||| .| .||| .|. .|.        ..|.. ||...   ||  . 
Ppspeilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq

DNA_ligase_A_M ATP dependent DNA ligase domain 276-443 5.7e-08 21.5 Pfam-A 18-193 (202) alignment
Range on Protein: 276-443
Range on HMM: 18-193/202.0
EKPYRVSWKADGTRyMLYIKGKGQIYLIDRDNSVFNS--PNITFLSRKREGEHLRDCVADSELVL-DKVDGAVRPRLLIYDIMMFEGS----KDVARCDH
|... |..| || | .   | .....|. |    . .  |...   ...  .. .... |.|||. ||  |. .|.  . .  . . .    |..  . .
egafiveeKyDGeR.vqvhkdgdevkllSRrgkditakkpellkalkeaflkdvksvildGElvavdketgeilpfqtlasrknkkkvkveekeaelsff

QRRMLCIDRELIMPREEAAKRGIIDKIR--EPFSVRAKQFWDVSESRMILEKYAPTLTHENDGLIYNPTNEPYKPGQ
   .|..| | .....   .| ....|   ..  .   .  .|...  . | ..  . .. .|..   .. .|.||.
vFDvlyldgesltdepleeRrklLeeifkesenrieiaetlevndveeleelleevikeglEGvvlKdpdskYepgk

0036941 (Phosphotyrosine protein) phosphatases II 118-183 7.4e-08 27.5 In-house 187-261 (297) alignment
Range on Protein: 118-183
Range on HMM: 187-261/297.0
VEKVKEFQMVCGEFFKDH-PYGVVGVHCTHGFNRTGFLIVSYLI--------DVECWDLEAAVATFSVARPPGIY
.. . .|   . .. |   . |.| ||| .| .|.| .|. .|.          ...|.  || ..   ||  . 
paslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq

0051299 (Phosphotyrosine protein) phosphatases II 118-184 8.9e-08 27.4 In-house 201-271 (288) alignment
Range on Protein: 118-184
Range on HMM: 201-271/288.0
VEKVKEFQMVCGEFFKdHPYGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYK
.| . .| . . .... .. |.| ||| .| .||| .|. .|.       ...|.. ||...   ||  .  
pellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt

subfamily_PTEN_pd Subfamily PTEN 114-178 2.9e-07 25.6 In-house 91-156 (184) alignment
Range on Protein: 114-178
Range on HMM: 91-156/184.0
CAPDVEKVKEFQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLE-AAVATFSVAR
..| .| ..|.     ....  .  || |||  |  ||| |||.||.    .. .  |.. |. ||
nppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR

subfamily_DSP23_pd Subfamily DSP23 114-182 5.4e-07 24.4 In-house 63-129 (148) alignment
Range on Protein: 114-182
Range on HMM: 63-129/148.0
CAPDVEKVKEFQMVCGEFfkDHPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGI
. | .|.|.||  |  |   ..    |.|||  |. ||| ..  ||.  .      |.|     ||  .
hppaleqvvefvrvveea..eekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsv

subfamily_CDC14_pd Subfamily CDC14 91-182 1.5e-06 22.3 In-house 211-308 (328) alignment
Range on Protein: 91-182
Range on HMM: 211-308/328.0
YRIGLVIDLTNTsrYYDKRELLQ-------------CAPDVEKVKEFQMVCGEFfkdhpYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVA
...  |. | .    ||...  .               |. . ||.|  .. .       | . |||  |. ||| || .||.       . |.| . ..
nnvttvvrLnkk..lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlric

RPPGI
||  .
rPGsv

subfamily_PTPDC1_pd Subfamily PTPDC1 138-186 2.7e-06 21.9 In-house 115-163 (182) alignment
Range on Protein: 138-186
Range on HMM: 115-163/182.0
GVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGIYKEH
| |.|||  |  ||| || .||. ..  . | |. .    ||  |.  .
gkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtre