Gene RNGTT-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily RNGTT
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP016_AA protein Get Run
AqueP016_AA_48-197 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_RNGTT_pd Subfamily RNGTT 41-213 7e-78 254.7 In-house 1-188 (189) alignment 
Range on Protein: 41-213
Range on HMM: 1-188/189.0
PRSWRHCPKEGSLIANKFLPFKTPLSSQYDKDLSEKERFPPSVLTSYRDT--YRIGLVIDLTNTSRYYDKREL---------LQCA-----PDVEKVKEF
|..|..||..|.|||.||||||||||..||.||.|..||.||.|.|| .|  ...|||||||||||||||.||         ||||     |. |.||||
PerWlnCPrkgkliaekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkef

QMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGIYKEHYLHELAGRYADGdIGSIITPPLPDWCD
.... ||||..|. |.|||||||||||||||||||...|.|..|||||.|. |||||||||.||.||. ||||    .| .| ||||| 
iklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadv.eeaiaapelpdwcl
mRNA_cap_enzyme mRNA capping enzyme, catalytic domain 262-451 1.8e-54 173.6 Pfam-A 1-192 (192) alignment 
Range on Protein: 262-451
Range on HMM: 1-192/192.0
QPVSMDVQNIRFLNEKPYRVSWKADGTRYMLYIKGKgQIYLIDRDNSVFNSPNITFLSRKR--EGEHLRDCVADSELVLDKVDGAVRPRLLIYDIMMFEG
||||.. .|...|..|.| ||.||||.|..|.|. | ..|||||||.|.  .|..|  ...  . ... . . | |||.|.| .  ..| |||||....|
qpvslsrenlkllkqkdYyvseKaDGlRvlllitkk.evylidrdnevylvenlkfplklekekekvhhgtllDGElvidtveeeqklryliyDilaing

SKdVARCDHQRRMLCIDRELIMPREEA-AKRGIIDKIREPFSVRAKQFWDVSESRM-ILEKYAPTLTHENDGLIYNPTNEPYKPGQCKDLLIWK
   |. .. . |. .. .|.| ||.|. .| .||..  |||.|| |.|.. . ..  . .| ...| ||.||||. ....||..|..|.|| ||
el.vserplskRleilkkeiikpraeeklkthiiktelepfkvrlksfilllalekllskkkikklsheiDGLIfqsvdtpYvagrdknllKWK
0038934 (Phosphotyrosine protein) phosphatases II 40-197 2.9e-43 143.1 In-house 2-175 (194) alignment 
Range on Protein: 40-197
Range on HMM: 2-175/194.0
IPRSWRHCPKEGSLIANKFLPFKTPLSSQYDKDLSEKERFPPSVLTSYRDTY--RIGLVIDLTNTSRYYDKRELLQ--------------CAPDVEKVKE
.|  |..... |..| ..|..||.|||. .|| ..|  ||.|. | .| ...  ..|||||||||.||||..|. .              ..|. | ...
lPdrwlkyervgdiitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillr

FQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGIYKEHYLHELAGRYAD
|  .. ||....| |||.|||..|..|||.|...||| . ....|.|.|.|. .||..|.. .||..|  || .
fldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryke
subfamily_DSP11_pd Subfamily DSP11 40-194 6.5e-33 108.1 In-house 1-173 (178) alignment 
Range on Protein: 40-194
Range on HMM: 1-173/178.0
IPRSWRHCPKEGS-LIANKFLPFKTPLSSQYDKDLSEKERFPPSVLTSYRD--TYRIGLVIDLTNTSRYYDKRELLQC-------------APDVEKVKE
.|  |..  . |. .  ..|..|||||....||...|..|| |. | .  .   ...||||||||| |||.|.|| .               |. | ||.
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkk

FQMVCGEFF--KDHPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGIYKEHYLHELAGR
|. .  ||   ...   ..||||||| ||||.||  |||||| .. | |. .|. ||   . .|.||..|  .
fkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkl
0036282 (Phosphotyrosine protein) phosphatases II 48-191 7.4e-19 63.5 In-house 9-162 (174) alignment 
Range on Protein: 48-191
Range on HMM: 9-162/174.0
PKEGSLIANKFLPFKTPLSsqydkDLSEKERFPPSVLTSYRDTYRIG--LVIDLTNTSRYYDKRELLQ---------CAPDVEKVKEFQMVCGEFFKDHP
|  .| | .... .. ||.     .. .  ..  ... .... .  |  ..|..... |.. .|. .|         ..||.... ||   . |.....|
pldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedp

YGVVGVHCTHGFNRTGFLIVSYLIDVECW-DLEAAVATFSVAR---PPGIYKEHYLHEL
 |.| |||..|..|||.|.. ||. .  . .|. |....  .|   |.... ..... |
ggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfl
mRNA_cap_C mRNA capping enzyme, C-terminal domain 455-542 7.9e-17 51.0 Pfam-A 5-98 (105) alignment 
Range on Protein: 455-542
Range on HMM: 5-98/105.0
VNFHLNIITEKKFGMLEEKKAQL-LV-GSERcEKIFSYLDLQVNKDAKKHSKKIIECSFVN--NKWKFLRVRTDKGFPDSIETAKSICI---DSV
| | |.. .|.. |.|||.| .| .| |    |.| .    ....| |. . ||.||.. .  ..|||||.|.||  | ||.||....    | |
vDfllklekeeedglLeeekgkldyveggsd.efitakekeklksdekelkgkIvEcklddkkgrWkflriRkDKsepNsistaekvlksiednv
0041856 (Phosphotyrosine protein) phosphatases II 90-185 1.7e-15 52.6 In-house 56-157 (182) alignment 
Range on Protein: 90-185
Range on HMM: 56-157/182.0
TYRIGLVIDLTntSRYYDKRELLQ-------------CAPDVEKVKEFQMVCGEffkdhPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSV
 ..|.....||  ...|.  .| .             ..||.... .|   . |     . |.| |||..| .|||.|.. ||. .  ..|| ||...  
elgittivnlt..eelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrs

ARPPGIYKE
.|| ..  .
rRpgmvitp
0040439 (Phosphotyrosine protein) phosphatases II 30-189 2.5e-15 52.2 In-house 13-236 (249) alignment 
Range on Protein: 30-189
Range on HMM: 13-236/249.0
SRRRSVHTQSIPRSWRHCPK---------------EGSLIANKFLPFKTPLSSqydkdlsekerfppsvlT-----SYRDTYRIGLVIDLTNTSRY----
...|...    ..|. .                  .|. | ..|. ...||..                 |      .   ..|. ...||.. ..    
dknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe.................tvedfwrmlwelgitvivmLtslvelgrek

---------------------------------------YDKREL------------LQCAPDVEKVKEFQMVCGEFFKDH-PYGVVGVHCTHGFNRTGF
                                       ||. ..             .. |..| . .|   . .....  . |.| |||..| .|||.
caqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

LIVSYLI-----DVECWDLEAAVATFSVARPPGIYKEHYLH
.|. ||.        ..||| ||...  .|| ... .... 
fiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr
0043147 (Phosphotyrosine protein) phosphatases II 80-191 3.8e-15 51.5 In-house 32-153 (172) alignment 
Range on Protein: 80-191
Range on HMM: 32-153/172.0
PPSVLTSYRDTYRIGLVIDLTNTsrYYDKRELL-------------QCAPDVEKVKEFQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDvECWD
. .    .  .. |.....||.   .||.  |              ...|. | . ||   . |..   | |.| |||..|..|||.|.. ||.  ....
tladfwrmlkelgithivnltel..lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lgls

LEAAVATFSVARPPGIYKEHYLHEL
|| |||..  .|| ... ..... |
leeavalvrekRpgavqnpsqyrfl
0044763 (Phosphotyrosine protein) phosphatases II 88-191 5.1e-15 51.0 In-house 44-163 (178) alignment 
Range on Protein: 88-191
Range on HMM: 44-163/178.0
RDTYRIGLVIDLTNTSRYYDKRELL-----------------QCAPD-VEKVKEFQMVCGEFFK-DHpyGVVGVHCTHGFNRTGFLIVSYLIDVECWDLE
   . |.....||.. ...   ..                   ..||  | . ||   . |. . ..  |.| |||..|..|.| |.. ||. .  ..||
lkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkklglsle

AAVATFSVARPpGIYKEHYLHEL
.|.. .  .|| ... ...|. |
eaielvrerRp.ivpnpgqlrqL
0049260 (Phosphotyrosine protein) phosphatases II 113-191 6.8e-15 50.5 In-house 65-142 (152) alignment 
Range on Protein: 113-191
Range on HMM: 65-142/152.0
QCAPDVEKVKEFQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDvECWDLEAAVATFSVARPPGIYKEHYLHEL
 ..|| . . .| .   |... .. |.| |||..|..|||.|.. ||.    ..|| ||| .  .|| ... ...|  |
hgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrfl
0048076 (Phosphotyrosine protein) phosphatases II 90-191 2.4e-14 48.7 In-house 27-135 (145) alignment 
Range on Protein: 90-191
Range on HMM: 27-135/145.0
TYRIGLVIDLTNTSRYYDKRELL--------QCAPDV-EKVKEFQMVCGEFFKDHpyGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPP
 . |..|..||.. ... .  .          ..||  | . ||   . |. |..  |.| |||..| .|||.|.. ||.  . ..|| |.. .  .|| 
dlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpg

GIYKEHYLHEL
... ...|. |
avpnpgqlrfl
PTEN_1 115-196 2.8e-14 48.4 In-house 107-189 (196) alignment 
Range on Protein: 115-196
Range on HMM: 107-189/196.0
APDVEKVKEFQMVCGEFFKDHP-YGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGIYKEHYLHELAGRYA
||. ... ..  .. |  . .|  .|| |||..| .|.|... .||.  . .. . |.. .  .||||     .. .|   .|
apslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfa
0048179 (Phosphotyrosine protein) phosphatases II 91-191 3e-14 48.5 In-house 28-137 (144) alignment 
Range on Protein: 91-191
Range on HMM: 28-137/144.0
YRIGLVIDLTNTsRYYDKRELL-----------QCAPDV-EKVKEFQMVCGEFFKDHpyGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVAR
. |..||.||.. ....  |              ..||  | . ||   . |. ...  |.| |||..|..|||.|.. ||. .. ..|| |.| .  .|
lgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrr

PPGIYKEHYLHEL
| ... ...|. |
pgavpnpgqlrfL
0040438 (Phosphotyrosine protein) phosphatases II 91-187 5.3e-14 47.7 In-house 109-264 (317) alignment 
Range on Protein: 91-187
Range on HMM: 109-264/317.0
YRIGLVIDLTNTSRY--------YDKRE----------------------------------------------LLQCAP-DVEKVKEFQMVCGEFFKdH
....... ||..  .        .  .|                                                ...| . . . .|   . |... .
qgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.d

PYGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYKEHY
| |.| |||..| .|||..|. ||.       ...|.| ||...  .|| ... . .
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeq
0045450 (Phosphotyrosine protein) phosphatases II 91-188 6.7e-14 47.8 In-house 130-293 (307) alignment 
Range on Protein: 91-188
Range on HMM: 130-293/307.0
YRIGLVIDLTNTS--------RYYDKR-------------------------------------------------ELLQCAPDVEKVKEFQMVCGEFFK
........||..         .|.                                                       .. |..| . .|   . ....
qgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkale

DH-PYGVVGVHCTHGFNRTGFLIVSYLIDVEC--------WDLEAAVATFSVARPPGIYKEHYL
.. . |.| |||..| .||| .|. ||. .          .||. ||...   || ..  ....
elpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy
0042113 (Phosphotyrosine protein) phosphatases II 55-188 1.7e-13 46.0 In-house 51-232 (245) alignment 
Range on Protein: 55-188
Range on HMM: 51-232/245.0
ANKFLPFKTPLSSqydkdlsekerfppsvL----TSYRDTYRIGLVIDLTNTSR---------------------------------------------Y
 .||. .  ||..                       .   ..|  ...||..                                               .
tpkfiatqgPlpe................tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgd

YDKRELLQ---------CAPD-VEKVKEFQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYKEHYL
. .|| ..         ..|| .| . .|   . .. .... |.| |||..| .||| .|. ||.        ...|| ||. .   ||  .  ....
desrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqy
0037934 (Phosphotyrosine protein) phosphatases II 91-188 5.5e-13 44.5 In-house 71-231 (243) alignment 
Range on Protein: 91-188
Range on HMM: 71-231/243.0
YRIGLVIDLTNTS--------------------------------------------RYYDKRELLQ---------CAPD-VEKVKEFQMVCGEFFKD--
..|. ...||..                                              .. .|.  .         ..|| .| . .|   . || ..  
lgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieell

-----HPYGVVGVHCTHGFNRTGFLIVSYLIDVE-CWDLEAAVATFSVARPP-GIYKEHYL
     .. |.| |||..| .||| ||. ||.    ..||| ||...   ||  ..  ....
sllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy
0049772 (Phosphotyrosine protein) phosphatases II 114-179 6.2e-13 44.6 In-house 192-255 (314) alignment 
Range on Protein: 114-179
Range on HMM: 192-255/314.0
CAPDVEKVKEFQMVCGEFfkdHPYGVVGVHCTHGFNRTG-FLIVSYLIDVECWDLEAAVATFSVARP
.||. | ..||  .. |.   .. |.| |||..| .||| |... ||.    ..|| |.. .  .||
saplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp
0051082 (Phosphotyrosine protein) phosphatases II 90-182 1.6e-12 42.8 In-house 31-136 (151) alignment 
Range on Protein: 90-182
Range on HMM: 31-136/151.0
TYRIGLVIDLTNTSRYY--------------DKRELLQCAPDVEKVKEFQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDvECWDLEAAVATFS
.. |  ...|...  ..              .   |  ..|...   .. .   |.. |.. |.| |||..| .|||.|.. ||.  . ..||.|.. . 
elgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyr

VARPPGI
  ||  .
lkrpgvv
0039614 (Phosphotyrosine protein) phosphatases II 92-188 2.4e-12 42.4 In-house 125-278 (297) alignment 
Range on Protein: 92-188
Range on HMM: 125-278/297.0
RIGLVIDLTNTSRY---------------------------------------------------YDKRELLQCAPDVEKVKEFQMVCGEFFKDH-PYGV
..  .. ||..  .                                                   | .    .. |..| . ||   . |...   . |.
gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggp

VGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYKEHYL
| |||..| .||| .|. ||.        ..|.. ||...  .|| ..  ....
vlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy
0043336 (Phosphotyrosine protein) phosphatases II 113-185 1.1e-11 40.2 In-house 186-263 (278) alignment 
Range on Protein: 113-185
Range on HMM: 186-263/278.0
QCAP-DVEKVKEFQMVCGEFFKdHPYGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYKE
...| ... . .|  .  |... .. |.| |||..| .||| .|. ||.     .  ..||| ||...   ||  .  .
hgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp
0046846 (Phosphotyrosine protein) phosphatases II 92-182 4.4e-11 38.3 In-house 47-156 (176) alignment 
Range on Protein: 92-182
Range on HMM: 47-156/176.0
RIGLVIDLTNTS--------RYYDK-----------RELLQCAPDVEKVKEFQMVCGEFFKDHpyGVVGVHCTHGFNRTGFLIVSYLIDV-ECWDLEAAV
.|..|..||.          .|..                 ..|| | . |.   . |. |..  |.| ||| .| .||| |.. ||.    ....| |.
gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveeal

ATFSVARP-PGI
|..   ||   .
alvreqRplgav
DSPc Dual specificity phosphatase, catalytic domain 138-191 2.5e-10 35.4 Pfam-A 74-127 (133) alignment 
Range on Protein: 138-191
Range on HMM: 74-127/133.0
GVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARpPGIYKE-HYLHEL
. | |||..| .|.. ||. ||.. ....|. |.. ..  | . | .  ..|..|
kkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skispnagflrqL
DSPc Dual specificity phosphatase, catalytic domain 138-191 2.5e-10 35.4 In-house 74-127 (133) alignment 
Range on Protein: 138-191
Range on HMM: 74-127/133.0
GVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARpPGIYKE-HYLHEL
. | |||..| .|.. ||. ||.. ....|. |.. ..  | . | .  ..|..|
kkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skispnagflrqL
PTPc_motif_SM00404 138-191 2.5e-10 35.4 In-house 81-134 (140) alignment 
Range on Protein: 138-191
Range on HMM: 81-134/140.0
GVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARpPGIYKE-HYLHEL
| | |||..| .|.. ||. ||.. . ..|..|.  ... | | | .  .....|
gkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR.piispnlnfvrqL
0045098 (Phosphotyrosine protein) phosphatases II 115-186 4.5e-10 34.9 In-house 169-259 (278) alignment 
Range on Protein: 115-186
Range on HMM: 169-259/278.0
APDVEKVKEFQMVCGEFFK---------------DHPYGVVGVHCTHGFNRTGFLIVSYLIDVE---CWDLEAAVATFSVARPP-GIYKEH
.|. . .| |. .. .  .               . . |.| ||| .| .||| |.. ||.       .||. ||...   ||   .  ..
vpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnle
0046845 (Phosphotyrosine protein) phosphatases II 114-185 1e-09 33.7 In-house 179-260 (284) alignment 
Range on Protein: 114-185
Range on HMM: 179-260/284.0
CA-PDVEKVKEFQMVCGEFFKD-HPYGVVGVHCTHGFNRTGFLIVSYLIDVE--------CWDLEAAVATFSVARPPGIYKE
.. |..| . ||   . |.... .. |.. ||| .| .||| .|. .|.           ..|.. ||. .   ||  .  .
gvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0047943 (Phosphotyrosine protein) phosphatases II 116-185 5.7e-09 31.3 In-house 183-258 (273) alignment 
Range on Protein: 116-185
Range on HMM: 183-258/273.0
PDVEKVKEFQMVCGEFFKDH-PYGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYKE
|..| . || ... ....     |.| ||| .| .||| .|. .|.        ..|.. ||. .   || ... .
pslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp
0051429 (Phosphotyrosine protein) phosphatases II 90-186 1.2e-08 30.4 In-house 43-212 (272) alignment 
Range on Protein: 90-186
Range on HMM: 43-212/272.0
TYRIGLVIDLTNTSRYYDKR-ELLQ-------------CAPDV----------------------------------------------------EKVKE
...|  ..||.... .     ...              .||..                                                    | ..|
elgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqealle

FQMVCGEffkdhpYGVVGVHCTHGFNRTGFLIVSYLIDvECWD--------------LEAAVATFSVARPPGIYKEH
.  .. .       | | |||..| .|||.... .|.  . ..              ||.||.    .||  .  |.
llellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee
0048567 (Phosphotyrosine protein) phosphatases II 117-182 1.6e-08 29.1 In-house 52-122 (157) alignment 
Range on Protein: 117-182
Range on HMM: 52-122/157.0
DVEKVKEFQMVCGEFFK--DHPYGVVGVHCTHGF---NRTGFLIVSYLIDVECWDLEAAVATFSVARPPGI
..  . .| ..  .|.|  ..  ... |||..|     ||..|| .||| .  .. | |.| ....||. .
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsv
0050432 (Phosphotyrosine protein) phosphatases II 115-183 3.2e-08 28.7 In-house 213-283 (308) alignment 
Range on Protein: 115-183
Range on HMM: 213-283/308.0
APDVEKVKEFQMVCGEFFKDhpyGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIY
 |..| . .|   . .....   |.. ||| .| .||| .|. .|.        ..|.. ||...   ||  . 
Ppspeilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq
DNA_ligase_A_M ATP dependent DNA ligase domain 276-443 5.7e-08 21.5 Pfam-A 18-193 (202) alignment 
Range on Protein: 276-443
Range on HMM: 18-193/202.0
EKPYRVSWKADGTRyMLYIKGKGQIYLIDRDNSVFNS--PNITFLSRKREGEHLRDCVADSELVL-DKVDGAVRPRLLIYDIMMFEGS----KDVARCDH
|... |..| || | .   | .....|. |    . .  |...   ...  .. .... |.|||. ||  |. .|.  . .  . . .    |..  . .
egafiveeKyDGeR.vqvhkdgdevkllSRrgkditakkpellkalkeaflkdvksvildGElvavdketgeilpfqtlasrknkkkvkveekeaelsff

QRRMLCIDRELIMPREEAAKRGIIDKIR--EPFSVRAKQFWDVSESRMILEKYAPTLTHENDGLIYNPTNEPYKPGQ
   .|..| | .....   .| ....|   ..  .   .  .|...  . | ..  . .. .|..   .. .|.||.
vFDvlyldgesltdepleeRrklLeeifkesenrieiaetlevndveeleelleevikeglEGvvlKdpdskYepgk
0036941 (Phosphotyrosine protein) phosphatases II 118-183 7.4e-08 27.5 In-house 187-261 (297) alignment 
Range on Protein: 118-183
Range on HMM: 187-261/297.0
VEKVKEFQMVCGEFFKDH-PYGVVGVHCTHGFNRTGFLIVSYLI--------DVECWDLEAAVATFSVARPPGIY
.. . .|   . .. |   . |.| ||| .| .|.| .|. .|.          ...|.  || ..   ||  . 
paslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq
0051299 (Phosphotyrosine protein) phosphatases II 118-184 8.9e-08 27.4 In-house 201-271 (288) alignment 
Range on Protein: 118-184
Range on HMM: 201-271/288.0
VEKVKEFQMVCGEFFKdHPYGVVGVHCTHGFNRTGFLIVSYLI-----DVECWDLEAAVATFSVARPPGIYK
.| . .| . . .... .. |.| ||| .| .||| .|. .|.       ...|.. ||...   ||  .  
pellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
subfamily_PTEN_pd Subfamily PTEN 114-178 2.9e-07 25.6 In-house 91-156 (184) alignment 
Range on Protein: 114-178
Range on HMM: 91-156/184.0
CAPDVEKVKEFQMVCGEFFKDHPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLE-AAVATFSVAR
..| .| ..|.     ....  .  || |||  |  ||| |||.||.    .. .  |.. |. ||
nppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
subfamily_DSP23_pd Subfamily DSP23 114-182 5.4e-07 24.4 In-house 63-129 (148) alignment 
Range on Protein: 114-182
Range on HMM: 63-129/148.0
CAPDVEKVKEFQMVCGEFfkDHPYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGI
. | .|.|.||  |  |   ..    |.|||  |. ||| ..  ||.  .      |.|     ||  .
hppaleqvvefvrvveea..eekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsv
subfamily_CDC14_pd Subfamily CDC14 91-182 1.5e-06 22.3 In-house 211-308 (328) alignment 
Range on Protein: 91-182
Range on HMM: 211-308/328.0
YRIGLVIDLTNTsrYYDKRELLQ-------------CAPDVEKVKEFQMVCGEFfkdhpYGVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVA
...  |. | .    ||...  .               |. . ||.|  .. .       | . |||  |. ||| || .||.       . |.| . ..
nnvttvvrLnkk..lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlric

RPPGI
||  .
rPGsv
subfamily_PTPDC1_pd Subfamily PTPDC1 138-186 2.7e-06 21.9 In-house 115-163 (182) alignment 
Range on Protein: 138-186
Range on HMM: 115-163/182.0
GVVGVHCTHGFNRTGFLIVSYLIDVECWDLEAAVATFSVARPPGIYKEH
| |.|||  |  ||| || .||. ..  . | |. .    ||  |.  .
gkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtre