Gene MTMR14 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR14
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP029_AA protein Get Run
AqueP029_AA_198-359 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR14_pd Subfamily MTMR14 39-360 4.7e-141 461.7 In-house 1-352 (357) alignment 
Range on Protein: 39-360
Range on HMM: 1-352/357.0
KMSLHLLARDYFIETVDNSDGNLCPHYPTHLMII-----AKREEDKDIVNNA---GRLKEFFK---------------------NICRSSTLSTAMELYG
|....||.||| ....||..|.||..||..|.|.     ...|..|..|..|    ||.|...                     |||||.|||.|.|.||
kkveellkrdyslsvidntnGelcsrypvkllileyelgegsegekelvesaydvqrlrelltkakyarcrerfvvpvilldgknicrsatlsvaaeiyg

RSGLDWVFSGKGKSGGSKEPEEVLQPKEKRLSEWALVDQAREFDSQLITALGVTLICDLMVEMRKTSYGLTLTSSEKADGRLWYSQFTIASLPYPGCEFF
||||....||. ..  .|| ||... ||.. .|.||.|..|. | .|...| |.||.|||||..|..|||...|||||| . .|..||..||||||.|||
rsGlnylasggeeadadkedeelitakedqaeeqalldrvrksdikllktlkvklivdlmvekkkvkyglavsssekadkekrykdftllslPyPGveff

VHYRQNKDSIGSVRYDWSMPSNDAVINVPSPLPESVGIDFTKYKSWNIIQHTQNYIKLLLHYLQYEE-GGILIHCVAGWDRTPLYISLLRLSLWADGHIH
 ..|.|| |. ...|.|.....|| .|.|. |..||.||...||.|.....||||.||||.|....| .|.|.||..|||||||..|||||||||||.||
kkfrdnkysaknlfynWkqdevdaelniPdklaasvdidwseykkWdlvaltqnylklllkyvkededsGllvhcisGWdrtPlfvsllrlslWadglih

KSLCPIEMLYLTLAYDWFMFGHKFEERLRKNEEVLYFCFDFLQHITSDDFSF
.||...|.||||.|||||.|||....||.|.||.|.||||.|..|||..||.
qslsaaellyltvaydWflfghqlpdrlkkgeeilffcfdvlkfitseefsi
Pkinase Protein kinase domain 460-744 2.1e-68 220.2 Pfam-A 1-260 (260) alignment 
Range on Protein: 460-744
Range on HMM: 1-260/260.0
YKILGRIGEGAHGVVLKARHTQTGDLVALKRVHLKKPADGIPNSALREIKALQESgENHHVICLRDMFPHGPGFVLVFDYMLS-DLAEVIRnAEKPLTEA
|..| ..|.|. |.|.||.. .||. ||.|... ..  .   ..||||.| |..  .  ... | ..| .   ..||..|.   ||..... ....|.| 
yelleklGsGsfGkVykakekktgkkvAvKilkkeeekskkektalrElkilkkl.nHpnivkllevfeekdelylvleyveggdlfdllk.kkgklsee

QVKSYMTMLLKGVAYLHDNKIMHRDLKPANLLISQTGHLKIADFGLARVLsTELGRLYSHQVATRWYRAPELLYGARQYDTGIDMWAVGCIFGELLNTSP
..|.... .|.|..|||.|.|.||||||.|.|....|.|||||||||..| .. .. ....|.||.|.|||.| .|..|.. .|.|..|.|. |||. ..
eikkialqilegleylHsngiiHrDLKpeNiLldekgelkiaDFGlakkl.eksseklttlvgtreYmAPEvllkakeytkkvDvWslGvilyelltgkl

LFPGENDIDQLCCVLRILGTPSERIWPGMSQLPdyhkisfsemsptpmevvvpdalPEAVDLLKSFLVYDSRHRLSAAKALLHSYF
.|.||.. ||| .. .||... |. .|  |. .                       .|. ||.|. | .| . ||.|...| |...
pfsgeseedqlelirkilkkkleedepksssks.......................eelkdlikkllekdpakRltaeeilkhpwl
0040695 (Phosphotyrosine protein) phosphatases II 39-359 1.9e-34 113.0 In-house 16-316 (388) alignment 
Range on Protein: 39-359
Range on HMM: 16-316/388.0
KMSLHLLARDYFIETVDNSDGNLCPHYPTHLmIIAKREEDKDIVNNAGRL------------KEFFKNICRSSTLSTamelygrsgldwvfsgkgksggs
...   | .|..  .  |... |||.|| .| .. |  .|..... |               ..  . ..|||.. .                       
elkrlglgldlwrisivNenyelcpsYPall.vVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplv.......................

kepeevlqpkEKRLSEWALVDQAREFDSQLITALGVTLICDLMvemRKTSYGLTLTSSEKADGRLWYSQFTIASLPYPGCEFFVHyrqnkdsigsvrydW
             ||..   .. .| . .|.. | . ||.||.   .|... ........ .   .|..... .|..|.....                .
..........glllsrsledeklleailkllpnlskllivdlr...pklnalanralgggvenedaypnaeliflnipnihvvre..............s

SMPSNDAVINVPSPLpeSVGIDFTKYKSWNIIQHTQNYIKLLLHYLQYEEGGILIHCVAGWDRTPLYISLLRLSLWADghiHKSLCPIEMLyltLAYDWF
 .   ||..|||. |  .. . . ... ...|...... .|....|. .. ..|.||  |||||....||..|.|...   ...|    .|   ....|.
lqklldaclnvpdsl..nllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPy...YRTleGFqvL...iekeWl

MFGHKFEERLRKNEE---------------------------VLYFCFDFLQHITSDDFS
.||||| .||   |.                           .. |.. .| ...   .|
sfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlys
Pkinase_Tyr Protein tyrosine kinase 463-656 4.2e-29 91.3 Pfam-A 4-201 (259) alignment 
Range on Protein: 463-656
Range on HMM: 4-201/259.0
LGRIGEGAHGVVLKARHT----QTGDLVALKRVHLKKPADGiPNSALREIKALQESgENHHVICLRDMFPHGPGFVLVFDYML-SDLAEVIRNA-EKPLT
  ..|||| | | ... .    ..   ||.| .. ..  .   .. |.|.| ...  ...... |  .  ..  ...|..|.   || . .|.  ...||
gkklGeGafGeVvegtlkgekekkevkVavKtlkeeaeeee.keefleeakimkkl.khenivkllgvctkeepllivteyvegGdLlkfLrkkekeklt

EAQVKSYMTMLLKGVAYLHDNKIMHRDLKPANLLISQTGHLKIADFGLARVL--STELGRLYSHQVATRWYrAPELLYGARqYDTGIDMWAVGCIFGELL
  .. |... . ||..||...|..||||   | |...... ||.|||||| .  . .  .  ....  .|. ||| |   . . .  |.|. | .  |..
ledllsfalqiAkGmeyLeskklvHrdLaarNvLleenkvvkisDfGLardiekddyykkkekaklpvkWm.apEslkekk.ftsksDvWsfGvllwEif

NT
..
tl
0044763 (Phosphotyrosine protein) phosphatases II 151-296 1.9e-09 32.9 In-house 38-130 (178) alignment 
Range on Protein: 151-296
Range on HMM: 38-130/178.0
EFDSQLITALGVTLICDLMVEMRKTSYGLTLTSSEKADgrlwysqftiaslpypgceffvhyrqnkdsigsvrydwsmpsndavinvpsplPESVGIDFT
. | .|. .||.|.|..|  |..   ...     |.|.                                                      . . | . 
addlellkelgithivnlteelelgflkcdpywpeeag.....................................................iqylhipip

KYKSWNIIQHTQNYIKLLLHYLQYEEGGILIHCVAGWDRTPLYISL
 ..  ....|... .... ..|. ..| .|.|| ||..|... . .
DhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaa
0051082 (Phosphotyrosine protein) phosphatases II 152-300 2.2e-09 32.6 In-house 24-116 (151) alignment 
Range on Protein: 152-300
Range on HMM: 24-116/151.0
FDSQLITALGVTLICDLMVEMRKTsY-GLTLTSSEkadgrLWYSQFTIASLPYPGceffvhyrqnkdsigsvrydwsmpsndavinvpsplpesvgidft
 . .|.  ||.. |..|. |.    |    |.. .     . . .. | . | ||                                             
dflellkelgiktivnlrseeerg.ycpeylpelg.....ievlhipildwpdpg.............................................

kykswnIIQHTQNYIKLLLHYLQYEEGGILIHCVAGWDRTPLYISLLRLS
      . .... ....| ..|. ..| .|.|| ||..|| . . |... 
......lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml
subfamily_MTMR1_pd Subfamily MTMR1 271-339 5.2e-09 27.9 In-house 207-269 (389) alignment 
Range on Protein: 271-339
Range on HMM: 207-269/389.0
YLQYEEGGILIHCVAGWDRTPLYISLLRLSLwaDGHIhKSlcpIEMLYLTLAYDWFMFGHKFEERLRKN
 .. |.  .|.||  |||||   .||  | |  | .  ..   || .   .. .| .|||||.||| . 
kvetektsvlvhcsdGWDRtaqltsLamlll..Dsyy.Rt...ieGfevliekeWlsfGHkfkeRlghg
subfamily_MTMR3_pd Subfamily MTMR3 269-341 6e-09 28.2 In-house 262-328 (442) alignment 
Range on Protein: 269-341
Range on HMM: 262-328/442.0
LHYLQYEEGGILIHCVAGWDRTPLYISLLRLSLwaDGhIHKSLCPIEMLyltLAYDWFMFGHKFEERLRKNEE
 . .. |.  .|.||  |||||.  ..| .| |  |   ...|   ..|   .  .|. ||||| .|   .|.
veavdkegrpvlvhCsdGWdrttqivalaklll..dp.yyrtleGfkvl...vereWldfGhkfadrcghgen
Kinase-like Kinase-like 541-648 9.6e-09 23.6 Pfam-A 126-239 (289) alignment 
Range on Protein: 541-648
Range on HMM: 126-239/289.0
LSDLAEVIRNAEKP--LTEAQVKSYMTM-LLKGVAYLHDNKIMHRDLKPANLLISQTGHLKIADFglaRVLSTElGRLYS-HQVAtRWYrAPELLYGAR-
|..| ... . ..     |  .. ..|. | . .|.|... ..| ...|.|.|. . | ... .|     | .. |. ..  .|. . . ||..| ... 
letlvkllqkrkeehkkletaarllLTlqlirlaanLqarglvhgkispdnflldekggvfLggf...taLvra.gkkvvvseve.kal.aPpellaekg

-------QYDTGIDMWAVGC
       ... ..| |..| 
gytsnttkmthkldaWqlGl
Myotub-related Myotubularin-like phosphatase domain 266-339 1.7e-08 26.6 Pfam-A 221-288 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 266-339 1.7e-08 26.6 In-house 221-288 (353) alignment
0051429 (Phosphotyrosine protein) phosphatases II 240-304 1.9e-08 29.8 In-house 115-178 (272) alignment 
Range on Protein: 240-304
Range on HMM: 115-178/272.0
PLPESVGIDFTKYKSWNIIQHTQNYIKLLLHYLQYeEGGILIHCVAGWDRTPLYISLLRLSLWAD
.  |.  .    | .|    . |.... ||..|.  .| .|.|| ||.||| ... ||.| |  .
sagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvallllllgvs
subfamily_MTMR6_pd Subfamily MTMR6 267-336 3.3e-08 25.2 In-house 214-277 (397) alignment 
Range on Protein: 267-336
Range on HMM: 214-277/397.0
LLLHYLQYEEGGILIHCVAGWDRTPLYISLLRLSLwaDGHIHkSlcpIEMLYLTLAYDWFMFGHKFEERL
.. .... |.  .|.||  |||||   .||  | |  | .   .   |. . . .  .|. |||||.|| 
fiakavaeegasvlvhcsdGwdrtaqvcslaslll..dpyyr.t...ikGflvliekewlsfGhkfserc
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 268-339 4.9e-08 24.5 In-house 214-279 (404) alignment 
Range on Protein: 268-339
Range on HMM: 214-279/404.0
LLHYLQYEEGGILIHCVAGWDRTPLYISLLrlSLWADGHIHKslcpIEMLYLTLAYDWFMFGHKFEERLRKN
... .. |.  .|.||. |||||.   ||    | .| .       ||  .  .  .|  |||||..| ...
iveliekekssvlvhcsdgwDrtsqlssls..qllldpyyrt....iegFivliekewlsfGhkfaqRigqt
0045098 (Phosphotyrosine protein) phosphatases II 240-302 1.9e-07 26.3 In-house 149-232 (278) alignment 
Range on Protein: 240-302
Range on HMM: 149-232/278.0
PLPESVGIDFTKYKSW--------NIIQHTQNYIKLLLHYLQY-------------EEGGILIHCVAGWDRTPLYISLLRLSLW
.  || |.   .|..|        .|... ..... ....|..             ..| .|.|| ||..||  .. .  .   
edlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlel
0049260 (Phosphotyrosine protein) phosphatases II 246-297 2.3e-07 26.2 In-house 59-110 (152) alignment 
Range on Protein: 246-297
Range on HMM: 59-110/152.0
GIDFTKYKSWNIIQHTQNYIKLLLHYLQYEEGGILIHCVAGWDRTPLYISLL
 . .  .  ....|. .  .... .......| .|.||.|| .||.... ..
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 277-337 4.2e-07 21.1 In-house 234-288 (405) alignment 
Range on Protein: 277-337
Range on HMM: 234-288/405.0
GGILIHCVAGWDRTPLYISLLRLSLwaDGHiHKSlcpIEMLYLTLAYDWFMFGHKFEERLR
  ||.||  ||||||   || .. |  | . ...   |  . . .  .|. |||||  || 
nsilvhcsdgwdrtpqitsltqill..dpy.yrt...ivgfqvliekewlsfghkfslrlg
0048179 (Phosphotyrosine protein) phosphatases II 243-299 4.6e-07 25.2 In-house 51-106 (144) alignment 
Range on Protein: 243-299
Range on HMM: 51-106/144.0
ESVGIDFTKYKSWNIIQHTQNYIKLLLHYLQyEEGGILIHCVAGWDRTPLYISLLRL
. . ...  .   ..... .. .... ..|. |.| .|.|| || .||.... . ..
qylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylm
0049772 (Phosphotyrosine protein) phosphatases II 249-302 4.8e-07 25.3 In-house 188-240 (314) alignment 
Range on Protein: 249-302
Range on HMM: 188-240/314.0
FTKyKSWNIIQHTQNYIKLLLHYlqYEEGGILIHCVAGWDRTP--LYISLLRLSLW
..   |...... .  ..... .   ..| .|.|| ||..||.  . . .| . |.
vpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg
0040439 (Phosphotyrosine protein) phosphatases II 248-299 1.4e-06 23.6 In-house 146-202 (249) alignment 
Range on Protein: 248-299
Range on HMM: 146-202/249.0
DFTKYKSWN---IIQHTQNYIKLLLHYLQY--EEGGILIHCVAGWDRTPLYISLLRL
 .|.    .    .... ..|......|..  ..| .|.|| || .||...| .. .
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm
0048076 (Phosphotyrosine protein) phosphatases II 247-297 1.7e-06 23.3 In-house 53-102 (145) alignment 
Range on Protein: 247-297
Range on HMM: 53-102/145.0
IDFTKYKSWNIIQHTQNYIKLLLHYLQYEeGGILIHCVAGWDRTPLYISLL
...  .   ..... .. .... ..|. . | .|.|| || .||.... . 
lpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaay
0043336 (Phosphotyrosine protein) phosphatases II 258-299 1.9e-06 23.1 In-house 192-233 (278) alignment 
Range on Protein: 258-299
Range on HMM: 192-233/278.0
IQHTQNYIKLLLHYLQYEEGGILIHCVAGWDRTPLYISLLRL
... ....| ....|. ..| .|.||.|| .|| ..| |..|
lsllldflkavrealedsngpvlVHCsaGvgRTGtfialyll
0043147 (Phosphotyrosine protein) phosphatases II 252-297 2e-06 23.1 In-house 76-121 (172) alignment 
Range on Protein: 252-297
Range on HMM: 76-121/172.0
YKSWnIIQHTQNYIKLLLH-YLQYEEGGILIHCVAGWDRTPLYISLL
.    .... .. .... . ......| .|.||.||..||.. . ..
hgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaay
0042113 (Phosphotyrosine protein) phosphatases II 251-299 2.3e-06 22.7 In-house 150-199 (245) alignment 
Range on Protein: 251-299
Range on HMM: 150-199/245.0
KYKSWNIIQHTQNYIKLLLHYLQ-YEEGGILIHCVAGWDRTPLYISLLRL
 ..  ..... .. .......|.  ..| .|.|| || .|| ..| ....
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm
0039614 (Phosphotyrosine protein) phosphatases II 252-299 2.5e-06 22.7 In-house 196-245 (297) alignment 
Range on Protein: 252-299
Range on HMM: 196-245/297.0
YKSWNIIQHTQNYIKLLLHYLQY--EEGGILIHCVAGWDRTPLYISLLRL
..  ..... .. ..|. ..|..  ..| .|.||.|| .||  .| ....
hgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylm