Gene MTMR5 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR5
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP032_AA protein Get Run
AqueP032_AA_1155-1722 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR5_pd Subfamily MTMR5 1539-1723 3.4e-83 272.1 In-house 194-378 (483) alignment
Range on Protein: 1539-1723
Range on HMM: 194-378/483.0
DALQEEIKDWKLLGLYVIGEKSSLVNVPTDIYPNCTLLPVEISSHVDIGNSFTKLMRACCPSGASSSTTHQSkFYSLVEDSDWINQLSSLLQLSGAVADL
.| ... . ..   |||.|||| | || .... .. ..|||.    .. .||.||.|||.|| |......|| |...||||.|..|.||||||||||.||
nakeskklrarkaaLYvlgeksqlknvksevdskaefipvelveirqvkasfkkllraClpstaveeaesqs.FlksvedseWlqqissllqlsgavvdl

MDAQGSSVLVGLEDGWDATAQVVSLAQLLMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQSSSG-AISPVFLQFLDCVHQEML
.|.|||||||.||||||.||||.||||||.||||||..||..|.||||||.|| ||.||.|..|... ...|||||||||||| . 
ldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsr

Myotubularin-like phosphatase domain 1558-1722 2.6e-54 177.3 Pfam-A 149-313 (353) alignment
Myotubularin-like phosphatase domain 1558-1722 2.6e-54 177.3 In-house 149-313 (353) alignment
0040695 (Phosphotyrosine protein) phosphatases II 1566-1720 1e-50 166.6 In-house 141-291 (388) alignment
Range on Protein: 1566-1720
Range on HMM: 141-291/388.0
PTDIYPNCTLLPVEISSHVDIGNSFTKLMRACcpsgasSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQ
..| |||..|....| .   . .|. ||..||       ..   ....||.|.|.|.......|.|.  ...|.| ..|||||  .|||| |.|..||||
nedaypnaeliflnipnihvvreslqklldac......lnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaq

LLMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQS--SSGAISPVFLQFLDCVHQ
||.||||||..||. |||||||..||.| ||. .  |  .|  .|||||.|||||.|
llldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwq

subfamily_MTMR1_pd Subfamily MTMR1 1568-1741 4.5e-46 149.9 In-house 143-313 (389) alignment
Range on Protein: 1568-1741
Range on HMM: 143-313/389.0
DIYPNCTLLPVEISSHVDIGNSFTKLMRACCPSgassstTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQLL
. | |..|. ..|..   . .|. ||  .. |.      ....|..| .|.. |.......|. . .... .. . .||||  .|||| |||..|||.||
eaYknaelifldihnihvvReslkklkelvlpn......vddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamll

MDPYYRTMKGFCALIEKEWLALGHPFTDRSCQ--IQSSSGAISPVFLQFLDCVHQEML-RPHSYQANLDIWVFYTED
.|.||||..||  |||||||. ||.|..|  .   .||    |||||||.|||.| .   |. .. | .. ..  . 
lDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldh

subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1567-1727 2e-43 141.1 In-house 151-308 (404) alignment
Range on Protein: 1567-1727
Range on HMM: 151-308/404.0
TDIYPNCTLLPVEISSHVDIGNSFTKLMRACcpsgaSSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQL
.. | ||..    |.   .. .|. ||  |.     .|.........| .|.| |......||. |  ...|.. ..|||||   ||||.|.|..||.||
isryenceieflnienihelreslkklkkav.....nsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsql

LMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQ-IQSSSGAISPVFLQFLDCVHQEMLR-PHS
|.||||||..||  ||||||| .|| |..|. |  . ||   ||.||||.|||.| . . |.|
lldpyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfpts

subfamily_MTMR3_pd Subfamily MTMR3 1567-1720 1.4e-42 139.0 In-house 199-348 (442) alignment
Range on Protein: 1567-1720
Range on HMM: 199-348/442.0
TDIYPNCTLLPVEISSHVDIGNSFTKLMRACcpsgasSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQL
.. |||| .  ....    . .|| .|   .      |.....|...| .|   |...|| ||. .  |.. .| .| .|||   |||| |.|.|.||.|
eeyypncevvflglanihavrksfnslrall......sqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakl

LMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQS--SSGAISPVFLQFLDCVHQ
|.||||||..|| .|.|.|||..|| |.||. . .    ..  .|||||.||.|||
lldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhq

subfamily_MTMR6_pd Subfamily MTMR6 1568-1731 1.7e-42 138.1 In-house 153-312 (397) alignment
Range on Protein: 1568-1731
Range on HMM: 153-312/397.0
DIYPNCTLLPVEISSHVDIGNSFTKLMRACcpsgaSSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQLL
| | |. .  |.|     . .| .||. ..       ... .|.|.| .|.|.|.  . ..|. |  .|  .  .| ||||   |||| ||||.|||.||
dnysnikfqfvgienihvmreslqkllevv.....elksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasll

MDPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQSSSGAISPVFLQFLDCVHQEML-RPHSYQAN
.||||||.|||  |||||||..|| |..|. .....|  .||.|.|||.|| | .  .|.... |
ldpyyrtikGflvliekewlsfGhkfsercGlldedskevsPiftqflecvwqlleqfpkafefn

subfamily_MTMR9_pd Subfamily MTMR9 1569-1722 5.6e-39 126.3 In-house 148-299 (393) alignment
Range on Protein: 1569-1722
Range on HMM: 148-299/393.0
IYPNCTLLPVEISSHVDIGNSFTKLMRACCPSGASsstthQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQLLM
 |.. .    ...|.  | .|..||. ||   | |     ..||.| .| | |..|.  ||...  ||...| .|..|.|  |.| ||| ||.|||||..
kysqwkkasrslesvasiqdslaklleacsdagls.....tdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlil

DPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQSSS---GAISPVFLQFLDCVHQEM
||..||..||.||||.||.  ||||. |  ..  ..      .|||| |||||.| .
dpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqil

subfamily_MTMR5_pd Subfamily MTMR5 1157-1261 8e-39 125.7 In-house 6-108 (483) alignment
Range on Protein: 1157-1261
Range on HMM: 6-108/483.0
SQSPYCIEYDRLGLGSLNFSvsKSRGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSASFKNPVSQGKSR
 .  |...|.|||||.||..  ..||..|.|..||..|.|..|||..|||...||.||.|. ..|.|.|.|.|||.|.|.||.|.||..|..    |. .
aerayvqdykRlGlgalnga..skrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgvvgllk

RVILT
 .  .
santq

subfamily_MTMR10_pd Subfamily MTMR10 1580-1722 3.6e-38 123.3 In-house 123-265 (380) alignment
Range on Protein: 1580-1722
Range on HMM: 123-265/380.0
ISSHVDIGNSFTKLMRACCPSGASSSTTHQSKFYSLVEDSDWINQLSSLLQLSGAVADLMDAQGSSVLVGLEDGWDATAQVVSLAQLLMDPYYRTMKGFC
. |  |..... ||.. | ..      | . |..|. | . |..  . .|...  .....  .. ||..  ..| |    | |||||..||.|||..||.
lpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfq

ALIEKEWLALGHPFTDRSCQIQSSSGAISPVFLQFLDCVHQEM
 ||.||| |.||||.||  .|..|... ||||| |||||.|..
sliqkewvaaghpfldrlghikpseksespvfllFldcvdqll

SBF2 Myotubularin protein 604-757 1.3e-35 112.0 Pfam-A 11-171 (225) alignment
Range on Protein: 604-757
Range on HMM: 11-171/225.0
STHRRVSNSLMRDVELLHKFLDALFSSRILEARKYFPSVTMSLRQRVTTPIFIPELVNKLMRNGAYLSPDQFEVMVRLVNCALVDE------KIAMQILP
 ... . ..  | .| |.. .  .| ..||||.| .| |  .|... .  ... || ..  .| | |  .||...|||.|.|| |.       .| ..||
ektkstvensarrlEvlrnCisyiFdnkileakKslpAvlralkskaaRlalceelekhvqqnravLdhqqFDlvvrlmNkaLqddsakdeygvaaallp

LTSVFYQEIQPGVNQYLYSCIQSHRLWQSTRFWCHSLYSAIQAELVRLYADvpfkkekP--------K
|.|.|.  . .||.|. |.|.| | .|....|| .. |. .|...  || .                |
lssafcRKLsegvsqfaYtcvqdHpvWknqqFWeatfyqevqkaikelyle.......kkseskkkkk

subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 1569-1721 7.3e-35 112.5 In-house 158-311 (405) alignment
Range on Protein: 1569-1721
Range on HMM: 158-311/405.0
IYPNCTLLPVEISSHVDIGNSFTKLMRACCPSGASSSTTH--QSKFYSLVEDSDWINQLSSLLQLSGAVADLMdAQGSSVLVGLEDGWDATAQVVSLAQL
 |||| |. ..|     | .|. ||. |   |      |   . .|.  .|.. || .. |.|. .   |.|.  .| |.||   |||| | |. ||.|.
nypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaeli.lkgnsilvhcsdgwdrtpqitsltqi

LMDPYYRTMKGFCALIEKEWLALGHPFTDRSCQIQSSSGAISPVFLQFLDCVHQE
|.||||||..||  |||||||..|| |. |  ..       ||.| |||||. | 
lldpyyrtivgfqvliekewlsfghkfslrlghlpgneeerspifqqfldccfql

DENN DENN (AEX-3) domain 186-383 9.5e-28 86.6 Pfam-A 3-184 (185) alignment
Range on Protein: 186-383
Range on HMM: 3-184/185.0
PLSLCLVAKYPIYDALQVLLKSIYIHHVMGDTldkfsssqlpvsphsTTMEELISELLIDLRFPLPGKPLVKRSFGPLKELTLVPLNiMETIPYTSDNTY
| .||.. ..|...... .|| .. ..  ...                ..|..|..|| .  .| |||.|.  | .  ....|   .  ...| .. . .
pkalcilsrlpffelfkkiLkalekrlksssk...............lplesfianlllevplPapgktlklkslsvkekillqrps.sselPledvdle

RLLKAIGVHGLLQLFSLILVDGKLLFISSSITAITSAIISVVSLMYPIGIDHFSCLLIPSGFVEYLHCITPFLMGLHRSLLVELDEEPLDVTLVDLDS
 |....... .||||...|.. .....|.... .||.. ..|.|.||.   |    ..|. ....|.. |||..|...|||  ..... ||.|||||.
elfrcLsienvlqlfeavLlErriillSeklarLtsvaealvallyPlkWqhiyiPvlpaslldvleaPtPfiiGvesslleleekpledvvlvDldt

0040695 (Phosphotyrosine protein) phosphatases II 1158-1257 3.4e-22 72.7 In-house 10-100 (388) alignment
Range on Protein: 1158-1257
Range on HMM: 10-100/388.0
QSPYCIEYDRLGLGSlnfsvsksrGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSASFKNPVSQGKSRR
   .. |. |||||            ||.|..|. ..||..|||..|||   ||| . |.. ....||.|.....||...| ||||. . .... ..|  
lydilrelkrlglgl.........dlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsle





Myotubularin-like phosphatase domain 1156-1246 1.3e-21 69.7 Pfam-A 21-103 (353) alignment
Myotubularin-like phosphatase domain 1156-1246 1.3e-21 69.7 In-house 21-103 (353) alignment
subfamily_pats1_pd Subfamily pats1 1612-1697 2.3e-19 61.2 In-house 369-457 (691) alignment
Range on Protein: 1612-1697
Range on HMM: 369-457/691.0
FYSLVEDSDWINQLSSLLQLSGAVADLMDaQGSSVLVG-LEDGWDATAQV---VSLAQLLMDPYYRTMKGFCALIEKEWLALGHPFTDRS
 .. .|.| |.. .  ||. .  |. |.| .|||||.    |. . . ..    ||||.|.||.|||. ||  |||||||  |.||....
ewkeieeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfskin

subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1164-1245 1e-18 59.7 In-house 24-97 (404) alignment
Range on Protein: 1164-1245
Range on HMM: 24-97/404.0
EYDRLGLGSLNfsvsksrgQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSAS
|| |||. |          .||.|.||. ..|||||| . ||| . ||| ....  . ..||.|...|.|. ... . ||. 
EykRlgikses........eWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssq

subfamily_MTMR1_pd Subfamily MTMR1 1164-1252 1.4e-17 56.1 In-house 15-95 (389) alignment
Range on Protein: 1164-1252
Range on HMM: 15-95/389.0
EYDRLGLGSLNfsvsksrgQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSASFKNPVSQ
|..|||| . .        .|| ...||...||.|||||.|||   ||| . ..    ..||.|...| .....|..||..     .|.
elerlgllnek........lWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsg

subfamily_MTMR9_pd Subfamily MTMR9 1180-1245 2e-16 52.1 In-house 30-95 (393) alignment
Range on Protein: 1180-1245
Range on HMM: 30-95/393.0
SRGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSAS
.  .||.|..|| |..|..||.  .||.. .||..  .  . ..||.|. .. | .||| ||||. 
asdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssq

subfamily_MTMR3_pd Subfamily MTMR3 1162-1244 5.7e-15 48.0 In-house 30-104 (442) alignment
Range on Protein: 1162-1244
Range on HMM: 30-104/442.0
CIEYDRLGLGslnfsvskSRGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSA
 .|..|||.          ...||.|..|..| ||..||   .|| . .|.....  ..   .|.| | |.| ...|.| |..
keeverlGfd........lkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcs

subfamily_MTMR10_pd Subfamily MTMR10 1178-1267 1.2e-13 42.6 In-house 20-109 (380) alignment
Range on Protein: 1178-1267
Range on HMM: 20-109/380.0
SKSRGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSASFKNPVSQGKSRRVILTKHGSSE
...  ... .. |. |. ..|.|   |||.. ||. . |.. |....| |. .|.|....| |. ||. ..   . .. ...| .  ...
ktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesadkekeekmlelvrkch

PH PH domain 2002-2106 3e-11 33.8 Pfam-A 2-102 (104) alignment
Range on Protein: 2002-2106
Range on HMM: 2-102/104.0
ELEGFLFKKGGVVKNWKERYFVLNLekGNLAYYESDKR--GAKLCGTIALEAIsKVEECDPIVVpstiLKSGQVGYFFKLTTNRR-VFTLMTFRTSTRSQ
..||.| ||..  |.||.|||||.   ..| |..|.|.   ... |.| |. . .|....        ... .  . |..|.. .  ..| .     |..
ikeGyllkksellktwkkryfvLts..nyLlyfksskkksykapkgsiplndc.tvkkasstkf....gaqkesnnyfeitfknvesyllsaeseeerkr

WIRKLTDS
|...| ..
Wvqalknl

uDENN uDENN domain 39-100 5.8e-11 31.7 Pfam-A 1-64 (65) alignment
Range on Protein: 39-100
Range on HMM: 1-64/65.0
KPRVCQRFPTENR-ASGSLPAGIELFCRSQGWCLTSHP-PPPSFNNFILTSELGSHFYCCSLNF
||.. ..|| ..      ||  |..||  .|. ...   ..|.|  |.||.| || .|...|.|
kpkildqfPekdeeedeplpkaipmFCfPeglnfvtsreqkpeffsfvLTdedgsriyGfClrf

subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 1179-1243 1.2e-10 32.7 In-house 37-101 (405) alignment
Range on Protein: 1179-1243
Range on HMM: 37-101/405.0
KSRGQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRS
.|   |....||| . .| .|..  || .|  |  . .|.    .||.| ..|| | ..| . | 
ssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrc

GRAM GRAM domain 978-1041 1.1e-08 25.9 Pfam-A 15-66 (69) alignment
Range on Protein: 978-1041
Range on HMM: 15-66/69.0
IIEGIRSFLLRDgrdtggrLVPAHGHVYLTSYRIVFLGSPWDPEVdpnvlVTRSMPISSIYRMK
... ..  | ..       ..|. |..|||.||..| ... |...     |....|...| |..
llddyaCylsts.......kgpvqGrlYlTnyrliFrSdklddsk.....vvvvipladikrve

subfamily_pats1_pd Subfamily pats1 1183-1283 1.4e-08 25.6 In-house 25-123 (691) alignment
Range on Protein: 1183-1283
Range on HMM: 25-123/691.0
QWRLSTINKSfTLCETYPAVWVVPDKFSDESITRILpHFQQGRVPIVTWKHPRTKAILLRSASFKNPVSQGKSRRVILTKHGSSEKISDSDLLGIQSADI
.||  .. ..  |.| ||   .||.  ||| .     . .. ..|...| ..  |. |.| . ...|. .       |.    |  | .  ..  .|. |
dwrvveflsr.dlseiyPkrilvPklvsdellvsyv.rkrsskiPvlswsnqnnksslfricvynqpfnnkfnsggtlaynnnstiinnnsviitrsssi

E
|
e

dDENN dDENN domain 437-496 3.2e-08 22.8 Pfam-A 2-58 (68) alignment
Range on Protein: 437-496
Range on HMM: 2-58/68.0
DKAVRSVFINVFLYLLGTYQHHVTVVRFHPEpkFHFDKESYIAQfCSGDDSDVWKAFINT
|..|| .| ..|  |||.|.....  | .||   .|.||... .  |  ...  ..|..|
dqqvreaFlrffasllggYrnflrkerkspe..vsFqkeaFlks.rskshrsFlsqflet

subfamily_MTMR6_pd Subfamily MTMR6 1182-1245 3.3e-08 25.2 In-house 36-99 (397) alignment
Range on Protein: 1182-1245
Range on HMM: 36-99/397.0
GQWRLSTINKSFTLCETYPAVWVVPDKFSDESITRILPHFQQGRVPIVTWKHPRTKAILLRSAS
 .| |. .||...||.|||   .|| . . | .        .||.|.... | ...| . |.. 
ekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsq

PH_8 Pleckstrin homology domain 2013-2053 2.4e-07 20.5 Pfam-A 10-51 (89) alignment
Range on Protein: 2013-2053
Range on HMM: 10-51/89.0
VVKNWKERYFVLNLEKGNLAYYESDKRGaKLCGTIALE--AIS
  .... |.|||.|....| ||..|. . .| | |.|.  .||
klqgyakRfFvLdlksstlsYyrddnss.alrgkiplslaiis

C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) 1907-1956 4.3e-07 19.6 Pfam-A 1-51 (53) alignment
Range on Protein: 1907-1956
Range on HMM: 1-51/53.0
HSFQSFKVGSTQYeCSYCHHII--RDKDAFKCKNCSGTCHNYCKRHMPSNCG
| ..  .. .... |..|  ..    | ..||..|. ..|. | ...|..||
Hhwvhrnfkqptf.CkhCgkflwgkgkqglkCswCqllvHkkCfekvpkecg

PH_11 Pleckstrin homology domain 2004-2052 1.9e-06 17.9 Pfam-A 2-52 (112) alignment
Range on Protein: 2004-2052
Range on HMM: 2-52/112.0
EGFLFKKGGV-VKNWKERYFVLNLeKGNLAYYES--DKRGAKLCGTIALEAI
.|.| |||   .| ||.|.|.|    . | ||.|  || . .| .    ..|
kGylkkkgskllkgWkrrwfiLrk.dnvleYyksprdksdvalitkesekvi