Gene OCA-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP037_AA protein Get Run
AqueP037_AA_6-183 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_OCA_pd Subfamily OCA 3-183 6e-48 153.6 In-house 106-277 (282) alignment 
Range on Protein: 3-183
Range on HMM: 106-277/282.0
IIWHI-FTQANFIVRWLSLILVLIDWLSGLHLFVKFYTWLVLNHFSVAKQYIDvvelaKPVIIDVIRFMC-REDSLPMLIhcahgkDRTGLLVAVVLGLL
.| || ......|.......|. ||...|.|.|...|.......||....| |     ||||....|... .|..||.||      ||.||..|..|.  
lirhignqvniiitilavmfllpidkifgthffprlyslvpprnfslveeykd.....kpvisgllrlllpeeenlpfLi......drlglktaliLdae

EVESEDIIrDY-AESQDGLLCIKDRVYQEIVERYGFKLECTY-AERETMEEVLEHiEKNYGSMSEYLLSGGFTLKEQEHFKRLFL
|||.|.|. |. |.|...|......|............|... |...|. .||.. .|.|||.|.|| . ||||..||..|.  |
everetia.dflasseiklvslrnevlkdlldndnyavelscqaktdtvlkvLrk.dkkygstsiyleyigFtledqeslksill
0051429 (Phosphotyrosine protein) phosphatases II 28-183 6.3e-25 83.8 In-house 103-272 (272) alignment 
Range on Protein: 28-183
Range on HMM: 103-272/272.0
LSGLHLFVKFYTWLVLNHFSVAKQYIDVVELAKPV--IIDVIRFMCRedSLPMLIHCAHGKDRTGLLVAVVLGLLEVESEDIIRDYAESQDGLLCIKDRV
    .| ....      .     .|.| .    |   ........ .  . |.|.||..||||||..||..| || |. |.|. ||. .  .|. . ...
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

YQEI---VER-----------YGFKLECTYAERETMEEVLEHIEKNYGSMSEYLLSGGFTLKEQEHFKRLFL
 .     |.              .  . . ...|... .|..|...|||. .|| . |.. .|.| ...|.|
raqrpgavqteeqylflyeallellrsllsvraeyllaaldaideeyGsvegYLrdlglseeelerLrellL
Y_phosphatase3 Tyrosine phosphatase family 47-114 5.7e-18 60.4 Pfam-A 97-163 (164) alignment 
Range on Protein: 47-114
Range on HMM: 97-163/164.0
SVAKQYIDVVELAKPVIIDVIRFMCREDSlPMLIHCAHGKDRTGLLVAVVLGLLEVESEDIIRDYAES
..|. | ...| .|. . .|.. . .|.. |.|.||..||||||...|..| ||.|..|.|..||. .
amaeayreiledekkayrkvlealaeeeg.pvlfHCtaGKDRTGvvaalllsllgvdeetiaaDYllt
0051082 (Phosphotyrosine protein) phosphatases II 55-128 2.8e-14 48.4 In-house 72-145 (151) alignment 
Range on Protein: 55-128
Range on HMM: 72-145/151.0
VVELAKPVIIDVIRFMCREDSLPMLIHCAHGKDRTGLLVAVVLGLLEVESEDIIRDYAESQDGLLCIKDRVYQE
 ..|  . ........ . .. |.|.|| .||.|||.|||..| || |  |.....| ..  |. . ..  . .
glplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlkrpgvvqpnqqflfq
0049772 (Phosphotyrosine protein) phosphatases II 61-158 1.6e-11 40.0 In-house 197-294 (314) alignment 
Range on Protein: 61-158
Range on HMM: 197-294/314.0
PVIIDVIRFMCR-EDSLPMLIHCAHGKDRTG--LLVAVVLGLLEVESEDIIRDYAESQDglLCIKDrVYQEIVERYGFKLECTYAERETMEEVLEHIEKN
  . ....|. . ..  | |.||..||.|||  ...| .. || |  |....|. .      .... .. |  |.| |.||. .   .. ... |..| |
edfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp..inpnp.gfieqleqyefilealleylkflkkfyeyleen

Y
.
l
0037934 (Phosphotyrosine protein) phosphatases II 9-114 5.9e-11 37.9 In-house 112-219 (243) alignment 
Range on Protein: 9-114
Range on HMM: 112-219/243.0
TQANFIVRWLSLILVLIDWLSGLHLFVKFYTWLVLNHFSVAKQYIDVVELAKPVIIDVIRFMCREDSLPMLIHCAHGKDRTGLLVAVVLGLL--EVESED
. ....|| |.|  . .| |. |.  . .. |   .  .  .. .| .. .. .| ... .... .. |.|.|| .|..|||.|.|  | ||  .|  |.
hlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdlee

IIRDYAES
..... | 
avkllreq
Y_phosphatase3C Tyrosine phosphatase family C-terminal region 142-183 1.7e-10 30.4 Pfam-A 26-68 (68) alignment 
Range on Protein: 142-183
Range on HMM: 26-68/68.0
AERETMEEVLEHIEKNYGSMSEYLLSG-GFTLKEQEHFKRLFL
...|..| .|..|...|||.  ||  . |..  ..| .....|
vreeyleaaldtideryGsvegYLeeaLGlseedierLRerlL
0042113 (Phosphotyrosine protein) phosphatases II 11-113 2.2e-10 35.9 In-house 120-220 (245) alignment 
Range on Protein: 11-113
Range on HMM: 120-220/245.0
ANFIVRWLSLILvLIDWLSGLHLFVKFYTWLVLNHFSVAKQYIDVVELAKPVIIDvirfmcrEDSLPMLIHCAHGKDRTGLLVAVVLG------LLEVES
....|| |..   | |. |  .. . .. |   .  .  .. .|..|... .. .        .. |.|.|| .|..|||...|. |       .|.|  
ddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalae.......dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsl

EDIIRDYAE
|...... .
eeavkelrs
0040439 (Phosphotyrosine protein) phosphatases II 12-111 1.9e-09 33.0 In-house 123-221 (249) alignment 
Range on Protein: 12-111
Range on HMM: 123-221/249.0
NFIVRWLSLILVlidwLSGLHLFVKFYTWLVLNHFSVAKQYIDVVELAKPVIidvirFMCR--EDSLPMLIHCAHGKDRTGLLVAVVLG------LLEVE
...|| | |  .      | .. |. . .. . ...| .   |.... . |       ...  ... |.|.|| .|..|||...|  |        |.| 
dytvrtleltnl....ydgesrtvlhiqytdwpdhgvppsfedlldfieavr.....kaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd

SEDIIRDY
 |......
leeavkll
0043147 (Phosphotyrosine protein) phosphatases II 63-111 2.1e-09 32.8 In-house 87-136 (172) alignment 
Range on Protein: 63-111
Range on HMM: 87-136/172.0
IIDVIRF-MCREDSLPMLIHCAHGKDRTGLLVAVVLGLLEVESEDIIRDY
... |.  ...... |.|.|| .|..|||.|||  | || .  |.... .
flefidellalspggpvlVHCsaGvgRtgtlvaaylmllglsleeavalv
0049260 (Phosphotyrosine protein) phosphatases II 60-110 2.5e-09 32.5 In-house 74-124 (152) alignment 
Range on Protein: 60-110
Range on HMM: 74-124/152.0
KPVIIDVIRFMCREDSLPMLIHCAHGKDRTGLLVAVVLGLLEVESEDIIRD
 . ....|........ | |.|| .|..|||.|||  | || |. |.... 
llflllfieklaldkggpvlVHCsaGvgRtgtlvaaylmllgvsleeaval
0043336 (Phosphotyrosine protein) phosphatases II 63-111 3e-09 32.2 In-house 198-252 (278) alignment 
Range on Protein: 63-111
Range on HMM: 198-252/278.0
IIDVIRFMCREDSLPMLIHCAHGKDRTGLLVAVVLG------LLEVESEDIIRDY
.. ..| ... .. |.|.|| .|..|||...|. |        ..|  |......
flkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel
0045098 (Phosphotyrosine protein) phosphatases II 10-108 3.6e-09 31.9 In-house 131-243 (278) alignment 
Range on Protein: 10-108
Range on HMM: 131-243/278.0
QANFIVRWLSLILVLIDWLSGLHLFVKFYTWLVLNHFSVAKQY-----IDVVELAKPVIIDVIRFM-----CREDSLPMLIHCAHGKDRTGLLVAVVLGL
  ....|.| .. . .   ..  ..|. . .|    ..|  .      ....|  . ..  .....     . ... |.|.|| .|..||| |||. | |
lddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylml

L----EVESEDII
      |  ....
elleggvdlleav
0045450 (Phosphotyrosine protein) phosphatases II 28-108 5.2e-09 31.7 In-house 190-276 (307) alignment 
Range on Protein: 28-108
Range on HMM: 190-276/307.0
LSGLHLFVKFYTWLVLNHFSVAKQYIDVVElakpvIIDVIRFMCRE--DSLPMLIHCAHGKDRTGLLVAVVLGLLEVESEDI---------I
 .| ...|. . ..   ...| .   ....     .|. .| ...|  .. |.|.|| .|..||| ..|  | |  .|.| .         .
gtgesrtvthfhytgwpdhgvppsfeelld.....fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleav
0039614 (Phosphotyrosine protein) phosphatases II 9-109 6.3e-09 31.2 In-house 165-262 (297) alignment 
Range on Protein: 9-109
Range on HMM: 165-262/297.0
TQANFIVRWLSLILvliDWLSGLHLFVKFYTWLVLNHFSVAKQYIDVVELAKPVIIDVirfmcrEDSLPMLIHCAHGKDRTGLLVAVVLGL------LEV
. ....||.|..     .  |  .  . .. |   .  . ... ....||.. ..         ... |.|.|| .|..||| ..|  | |       .|
hldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealael......pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

ESEDIIR
  .....
dvleavk
0036282 (Phosphotyrosine protein) phosphatases II 56-108 1.5e-08 30.0 In-house 83-139 (174) alignment 
Range on Protein: 56-108
Range on HMM: 83-139/174.0
VELAKpvIIDVIRFMCR----EDSLPMLIHCAHGKDRTGLLVAVVLGLLEV--ESEDII
 .|..  ......|. .     .. |.|.|| .|..|||.|||  | |       .|..
pdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdal
0048076 (Phosphotyrosine protein) phosphatases II 61-109 1.9e-08 29.6 In-house 65-116 (145) alignment 
Range on Protein: 61-109
Range on HMM: 65-116/145.0
PVIIDVIRFM--CREDSLPMLIHCAHGKDRTGLLVAVVLGLL-EVESEDIIR
  ......|.  ....  |.|.|| .|..|||.|||  | ||  |  |....
ellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleeale
0051299 (Phosphotyrosine protein) phosphatases II 7-106 2.5e-08 29.2 In-house 156-250 (288) alignment 
Range on Protein: 7-106
Range on HMM: 156-250/288.0
IFTQANFIVRWLSLILVLIDWLSGLHLFVKFYTWLVLNHFSVAKQYIDVVELAKPVIIDVIrfmcrEDSLPMLIHCAHGKDRTGLLVAVVLGLLEVESED
. ......||.| .  . .   .| ...|. . ..   ...|     ..... . |.          .. |...|| .|..||| ..|. | |  .| | 
eevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.....sgggpvvVHCsaGvgRtgtfialdllleqlekeg
0040438 (Phosphotyrosine protein) phosphatases II 64-108 2.5e-08 29.0 In-house 198-248 (317) alignment 
Range on Protein: 64-108
Range on HMM: 198-248/317.0
IDVIRFMCREDSLPMLIHCAHGKDRTGLLVAVVLGLLEVES------EDII
.. .|  ..... |.|.|| .|..||| ..|. | |  .|       |...
leavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeav
Y_phosphatase2 Tyrosine phosphatase family 49-112 2.9e-08 25.7 Pfam-A 65-128 (165) alignment 
Range on Protein: 49-112
Range on HMM: 65-128/165.0
AKQYIDVVELAKPVIIDVIRFMCREDSLPMLIHCAHGKDRTGLLVAVVLGLLEVESEDIIRDYA
 ..  . ||. . ..  .....  ..  |.|.|| .|| ||||.....  | . .   |. .| 
esnkeelveiksdllkkalklllnkenypvllhckrGkhrtglvigclRklqkWslasilnEyr
0048179 (Phosphotyrosine protein) phosphatases II 61-100 4.8e-08 28.4 In-house 67-109 (144) alignment 
Range on Protein: 61-100
Range on HMM: 67-109/144.0
PVIIDVIRFM--CREDSLPMLIHCAHGKDRTGLLVAVVLGL-L
  ......|.  ..|.. |.|.|| .|..|||.|||  | . |
ellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkkl
0041856 (Phosphotyrosine protein) phosphatases II 57-101 6.4e-08 27.9 In-house 94-136 (182) alignment 
Range on Protein: 57-101
Range on HMM: 94-136/182.0
ElaKPVIIDVIRFMCReDSLPMLIHCAHGKDRTGLLVAVVLGL-LE
.   . ..| |. . . .. | |.|| .|..||| |||  | . |.
d..ldelldfieevle.eggpvlVHCsaGvgRtgtlvaaylmkklg
0046845 (Phosphotyrosine protein) phosphatases II 9-106 1e-07 27.1 In-house 144-235 (284) alignment 
Range on Protein: 9-106
Range on HMM: 144-235/284.0
TQANFIVRWLSLILVlidWLSGLHLFVKFYTWLVLNHFSVAKQYIDVVELAKPVIIDVIRfmcREDSLPMLIHCAHGKDRTGLLVAVVLGLLEVESED
.. ...||.|.|  .    ..| ...|. . ..   ...|  .  |..|. . |     .   .... |...|| .|. ||| ..|. | |  .| |.
vkddytvrtleltnl...gytgesrtvthfhytswpdhgvppspedlleflrlvrellen...lpgggpivVHCsaGvgRtGtfialdllleqlekeg
0044763 (Phosphotyrosine protein) phosphatases II 63-97 4e-07 25.4 In-house 98-132 (178) alignment 
Range on Protein: 63-97
Range on HMM: 98-132/178.0
IIDVIRFMCREDSLPMLIHCAHGKDRTGLLVAVVL
... |.    |.  | |.|| .|..|.|.|||  |
fvefieealdekggpvlVHCsaGvgRsgtlvaayl
0046846 (Phosphotyrosine protein) phosphatases II 64-111 6.5e-07 24.8 In-house 99-147 (176) alignment 
Range on Protein: 64-111
Range on HMM: 99-147/176.0
IDVIRFMCREDsLPMLIHCAHGKDRTGLLVAVVLGLL--EVESEDIIRDY
.. || . .|.  | |.|| .|. |||.|||  |  |   .  |.... .
lefirealkeg.gpvlVHCsaGigRtgtlvaayllelekglsveealalv
0036941 (Phosphotyrosine protein) phosphatases II 64-103 7.5e-07 24.2 In-house 194-235 (297) alignment 
Range on Protein: 64-103
Range on HMM: 194-235/297.0
IDVIRFMCRE--DSLPMLIHCAHGKDRTGLLVAVVLGLLEVE
|. .| ....  .. |.|.|| .|. |.| ..|. | |  .|
ielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqle
subfamily_PTPN13_pd Subfamily PTPN13 64-124 1.3e-06 22.9 In-house 192-257 (273) alignment 
Range on Protein: 64-124
Range on HMM: 192-257/273.0
IDVIRFMCReDSLPMLIHCAHGKDRTGLLVA--VVLGLLEVES----EDIIRDYAESQDGLLCIKDR
.  .| . . |..|...||. |  |.| |..  |||||.| .     ..|.|.  | ..|..  ||.
vaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdq
0050432 (Phosphotyrosine protein) phosphatases II 29-106 1.4e-06 23.3 In-house 193-263 (308) alignment 
Range on Protein: 29-106
Range on HMM: 193-263/308.0
SGLHLFVKFYTWLVLNHFSVAKQYIDVVELAKPVIIDVirfmcreDSLPMLIHCAHGKDRTGLLVAVVLGLLEVESED
.|  ..|. . ..   ...|  .  ..... . |           .. |...|| .|  ||| ..|. | |  .| | 
dgesrtvthfhytnWpdhgvPpspeilldflelvrksl.......pggpivVHCsaGvGRtGtfialdllleqlekeg
0047943 (Phosphotyrosine protein) phosphatases II 32-106 1.4e-06 23.4 In-house 165-236 (273) alignment 
Range on Protein: 32-106
Range on HMM: 165-236/273.0
HLFVKFYTWLVLNHFSVAKQYIDVVElakpvIIDVIRFMCRE--DSLPMLIHCAHGKDRTGLLVAVVLGLLEVESED
 ..|. . ..    ..|  .. ...|     .|...| ....  .. |...|| .|. ||| ..|. | |  .| | 
srtvthfhytgwpdhgvppsleslle.....fielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeg
PTPc_DSPc_SM00012 75-106 1.5e-06 23.7 In-house 39-70 (105) alignment 
Range on Protein: 75-106
Range on HMM: 39-70/105.0
SLPMLIHCAHGKDRTGLLVAVVLGLLEVESED
| |...|| .| .||| .||. . |  .|.| 
skpvvVhCsaGvgRtgtfvaldillqqleket
subfamily_Ptp69D_pd Subfamily Ptp69D 63-111 1.8e-06 22.3 In-house 207-255 (307) alignment 
Range on Protein: 63-111
Range on HMM: 207-255/307.0
IIDVIRFMCREDSLPMLIHCAHGKDRTGLLVAVVLGLLEVESEDIIRDY
.|. .| . . .  |...||  | .|.|..||. . | ... || .  .
lieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdif
0038934 (Phosphotyrosine protein) phosphatases II 67-99 2.4e-06 22.9 In-house 107-139 (194) alignment 
Range on Protein: 67-99
Range on HMM: 107-139/194.0
IRFMCREDSLPMLIHCAHGKDRTGLLVAVVLGL
 .|. .  .   ..|| .|. |||.|||  |  
deflnedpggvvaVHCkaGlgRtGtlvaaYLiy
subfamily_RNGTT_pd Subfamily RNGTT 67-136 4e-06 20.6 In-house 105-174 (189) alignment 
Range on Protein: 67-136
Range on HMM: 105-174/189.0
IRFMCREDSLPMLIHCAHGKDRTGLLVA-VVLGLLEVESEDIIRDYAESQDGLLcIKDRVYQEIVERYGFK
 .|.... .  . .|| || .||| |..  ..   ... |. .. .|.. .  .  |.   .|...||.  
eeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGi.ykedylkellrrYadv