Gene Auxilin-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Auxilin
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP039_AA protein Get Run
AqueP039_AA_424-576 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Auxilin_pd Subfamily Auxilin 428-582 2.6e-66 215.4 In-house 5-155 (166) alignment
Range on Protein: 428-582
Range on HMM: 5-155/166.0
KQKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNV
 ....||.|.||||.|||.|.|. .....|....|...||..||..|||.|||...|.|..||..||...||.|..|.||||||.||.|.|||..|.|||
akndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknv

LVIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGqgmdISPSDRR
.|.|||||...|..||...|.|.|.|..|.||.|||...|||.|    .|||..|
vvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig....lspsekr

subfamily_Tensin_pd Subfamily Tensin 429-582 1.8e-38 124.9 In-house 8-162 (189) alignment
Range on Protein: 429-582
Range on HMM: 8-162/189.0
QKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVL
.   |.||.|.||...|.| |       . ||.||. |.  | ..|||||||  .|| ..|. .|.|. ||.   |.|| |  .|..|||||.|| .||.
kvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvv

VIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQG-MDISPSDRR
|.||| |    |..| .|. . .   | ..||  |. .|. . .   .. || ||
vvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrr

subfamily_PTEN_pd Subfamily PTEN 431-582 1.4e-33 111.4 In-house 19-170 (184) alignment
Range on Protein: 431-582
Range on HMM: 19-170/184.0
STDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNL-SGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLV
  |..|.|..|..|.|| |.      | |..|  .|| .|  .| ..|| |...||.....|.|  |.  .   |||| | |.......|| .| ||| |
dLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvv

IHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQGMDIsPSDRR
.||| |   .|.|.|.|||  . |.....||.||.. |  ...|. | || ||
vHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvti.PsqrR

Pkinase Protein kinase domain 239-392 3.3e-33 104.9 Pfam-A 2-148 (260) alignment
Range on Protein: 239-392
Range on HMM: 2-148/260.0
KVKKVIAEGGYGFVFVAQDTSTGIDYALKRQIVASENIKAIKQ---EITFLTQLsGHPHIIHFIGAASSkdpaggSAEFLIVTELITGGELVDIVN-TRS
.... . .|..| |. |.. .||  .|.|.    .|. |. |.   |.  |..|  ||.|......  .      . |...|.|.. ||.| |...  . 
elleklGsGsfGkVykakekktgkkvAvKilkkeeekskkektalrElkilkkl.nHpnivkllevfee......kdelylvleyveggdlfdllkkkgk

LSPHQVLRVFYETCQAIAHMHSQtpPIIHRDIKVgvENLLLTDKGSVKLCDFGSATTQ
|| ... .............||.   |||||.|   ||.||..||..|..|||.| . 
lseeeikkialqilegleylHsn..giiHrDLKp..eNiLldekgelkiaDFGlakkl

subfamily_VSP_pd Subfamily VSP 432-572 2.3e-26 87.0 In-house 34-175 (212) alignment
Range on Protein: 432-572
Range on HMM: 34-175/212.0
TDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNLSGE-QYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVI
 |.|||| ||. ||.|         | ..||| .|.  |. .| |.||  | .||   .  .|.     .  .| || |. .....  || .| ||||.|
ldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvlai

HCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQ
||| |   .| .| ..||   .. .   .|  |. ||  ...
hckGGkgrtGtivcalllaseifetakesldyfgerrtdkte

PTEN_1 429-571 9.1e-23 76.1 In-house 17-175 (196) alignment
Range on Protein: 429-571
Range on HMM: 17-175/196.0
QKSTDITYVTSRILVMSYPFEEG------GVGRPNVLKEVAAYLEGTHPSQ-YLVFNLSGEQ------YDTDQ---LSGQVVDYEWPNRAMPPLESLVEL
 . .|.||.||||..|.... ..      .    . ||.|||.|.  ...  .||.||| |       || ..      .. .....    |.|..| . 
telldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdi

CRQLDSWLRADF-KNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRLPEG
|.....||..|  .|| ..||| |.  || .| .||....   ..  ||.|. ..| | .
cksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppga

Pkinase_Tyr Protein tyrosine kinase 238-392 2e-22 69.4 Pfam-A 1-153 (259) alignment
Range on Protein: 238-392
Range on HMM: 1-153/259.0
LKVKKVIAEGGYGFVFVAQDT----STGIDYALKRQ--IVASENIKAIKQEITFLTQLsGHPHIIHFIGAASSKDPaggsaeFLIVTELITGGELVDIVN
|...| ..|| .| |. .. .    .. .. |.|       .|. ... .|......|  |..|....|. ....|      .|||||...||.| . ..
lelgkklGeGafGeVvegtlkgekekkevkVavKtlkeeaeeeekeefleeakimkkl.khenivkllgvctkeep......llivteyvegGdLlkfLr

TR---SLSPHQVLRVFYETCQAIAHMHSQTppIIHRDIKvgVENLLLTDKGSVKLCDFGSATTQ
..   .|. ...|.. .. ........|..  ..|||.     | ||.... ||..||| | . 
kkekekltledllsfalqiAkGmeyLeskk..lvHrdLa..arNvLleenkvvkisDfGLardi

0036282 (Phosphotyrosine protein) phosphatases II 433-567 1.7e-21 72.2 In-house 11-146 (174) alignment
Range on Protein: 433-567
Range on HMM: 11-146/174.0
DITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNLSGEQ-YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVIH
|..|.|.|......|..     . . .. |  .||  ..  |...|.  |  .|  .|  |.... || . .|.|. | |........|  | ......|
dlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVH

CKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARR
|. ||. .|.||. ||.  . |.|.  ||.|. ..|
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelR

0038934 (Phosphotyrosine protein) phosphatases II 436-567 1.7e-17 59.2 In-house 15-156 (194) alignment
Range on Protein: 436-567
Range on HMM: 15-156/194.0
YVTSRILVMSYPFEEGGVGRP-----NVLKEVAAYLEGTHPSQYLVFNLS--GEQYDTDQLSG---QVVDYEWPNR-AMPPLESLVELCRQLDSWLRADF
..| |......| ..    .      . .. .  ||.  .   .|| .|.  .  ||.. . .   ..... .|.. . |.|| | . .. .| .|..| 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

KNVLVIHCKDGVHPSGILVVSYLLFLRALpSPSSALRLFTARR
..| ..||| |.  .|.||..||.  . . |.  |..||. .|
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR

0041856 (Phosphotyrosine protein) phosphatases II 430-576 2.4e-15 52.1 In-house 15-155 (182) alignment
Range on Protein: 430-576
Range on HMM: 15-155/182.0
KSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQY-LVFNLSGEQYDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSwlradFK
 | |..|.. .....|.|. .  .   . |..||..|.  .  .. .. ||..|.|. . |     |.... ||    |.|..|......  .      .
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eg

NVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRlpegQGMDI
.. ..||. ||. .| ||. ||.  .   |. .|..|.  ||     || |
gpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR....pgmvi

0043147 (Phosphotyrosine protein) phosphatases II 433-568 2.7e-14 48.7 In-house 14-141 (172) alignment
Range on Protein: 433-568
Range on HMM: 14-141/172.0
DITYVTSRILVMSYPfeeggvgRPNVLKEVAAYLEGTHPSQylVFNLSGEQYDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLV
|..|.. |.... .|        .| | .. ..|   . .   ..|| ...||...|.    |.  . ||    |.|| | |.....|..|  . ... .
dlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvl

IHCKDGVHPSGILVVSYLLFlRALpSPSSALRLFTARRL
.||. ||  .| ||. ||.  . | |.  |..|. ..| 
VHCsaGvgRtgtlvaaylml.lgl.sleeavalvrekRp

0046846 (Phosphotyrosine protein) phosphatases II 431-568 4e-14 48.2 In-house 9-152 (176) alignment
Range on Protein: 431-568
Range on HMM: 9-152/176.0
STDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGthpSQYLVFNLSGEQ-----------YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSW
  |..|.. .....|.|    |  . .. . .. ..|      ..|.||  |.            .  .|. |.  . ||    |.|| | ||.......
dldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirea

LRADfkNVLVIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRL
|...  .. ..||. |.  .| ||. ||| |.   |.  ||.|. ..| 
lkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRp

0039614 (Phosphotyrosine protein) phosphatases II 432-567 2.8e-13 45.4 In-house 83-268 (297) alignment
Range on Protein: 432-567
Range on HMM: 83-268/297.0
TDITYV-----------TSRILVMSYPFEEggvgrpnvlkEVA-------------------------------------------AYLEGTHPSQYLVF
 | .|.           | .......| .|           |.                                            .|. .| . | |.
ldsdYinAsyvdgydlltrkfIatqgPlpe..........tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvr

NLSGEQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFTARR
.|. . ..      ..  . ||    || ||.| |........|...  ... ..||..||. .| ... ||..     .  ... .|.. .  .|
tlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR

0037934 (Phosphotyrosine protein) phosphatases II 433-568 6.5e-13 44.3 In-house 38-221 (243) alignment
Range on Protein: 433-568
Range on HMM: 38-221/243.0
DITYVTSRILVMSYPFEEGGVG----RPNVLKEV---------------------------------AAYLEGTHPSQYLVFNLSGEQY---DTDQLSGQ
. .||| |. ....| .|          . |.|                                    .|. .| ..| |..|. | .   |  .|  .
nliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvih

VVDYEWPNRAMPP-LESLVELCRQLDSWLRA-------DFKNVLVIHCKDGVHPSGILVVSYLLFLR-AlPSPSSALRLFTARRL
.  . ||   .|.  |.|....... .....       | ......||. ||. .| |.. ||. |.    .. .|..|. ..| 
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg.vdleeavkllreqRp

0049772 (Phosphotyrosine protein) phosphatases II 428-568 8e-13 44.2 In-house 49-255 (314) alignment
Range on Protein: 428-568
Range on HMM: 49-255/314.0
KQKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNLS-----------------------------------------------
|. ..||  . .|  . ..|..  .    . .. . ...   .|... |....                                               
knryldilpadnrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpl

-------------------GEQYDTDQLSGQVVDY---EWPNRAMPPLESLVELCRQLDSWlraDFKNVLVIHCKDGVHPSGI-LVVSYLLFLRALpSPS
                   .|.|| . ...... |    .|    |.|| . |... ....   | ......|||.|.. .|  .|. ||. |. . |. 
lildgngneptaadlellkeelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sle

SALRLFTARRL
 ||. . ..| 
ealedvrlkRp

0042113 (Phosphotyrosine protein) phosphatases II 438-567 1.1e-12 43.4 In-house 51-222 (245) alignment
Range on Protein: 438-567
Range on HMM: 51-222/245.0
TSRILVMSYPFEEggvgrpnvlkEVA---------------------------------------------AYLEGTHPSQYLVFNLSGE--QYDTDQLS
| .......| .|           |.                                              .|. .| . | |..|. .  ..|  .  
tpkfiatqgPlpe..........tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrev

GQVVDYEWPNRAMPP-LESLVELCRQLDSWLRADFKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFTARR
 ..  . ||   .|. ||.|..... ....|..| ......||..||. .| ... ||..     .   |. .|.. .  .|
ihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR

0051082 (Phosphotyrosine protein) phosphatases II 432-568 1.7e-12 42.7 In-house 6-133 (151) alignment
Range on Protein: 432-568
Range on HMM: 6-133/151.0
TDITYVTSRILVMSYPFEeggvgrpnvlkEVAAYLegTHPSQYLVFNLSGEQ---YDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSWLRADFK
....|||........| .           .. ..|   .   . ..|| .|.   |... |     .|... ...   |.|. . . .... ..|... .
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVLVIHCKDGVHPSGILVVSYLLFLRalPSPSSALRLFTARRL
.....||. |.. .|.||. ||. |.   |. .||. . ..| 
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp

0048076 (Phosphotyrosine protein) phosphatases II 474-568 2.6e-12 42.1 In-house 31-123 (145) alignment
Range on Protein: 474-568
Range on HMM: 31-123/145.0
YLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPL-ESLVELCRQLDSWLRADfkNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRL
..|.||. |...  .|  |.. . || .  |.| | | |........|...  .. ..||. ||. .| ||. ||..|.   |. .||.|. ..| 
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllg.vsleealelvrsqrp

0044763 (Phosphotyrosine protein) phosphatases II 430-567 2.9e-12 42.1 In-house 19-151 (178) alignment
Range on Protein: 430-567
Range on HMM: 19-151/178.0
KSTDITYVTSRILVMSYPFeeggvgrpnvlKEVAAYLEGTHPSqyLVFNLSG---------EQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSW
  ....... .....|.|             .  ..|   . .  .. ||..          .|. .. . |.. . .|    |. || . |... ....
dyinaseilpglylgslpp...........addlellkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieea

LR-ADfKNVLViHCKDGVHPSGILVVSYLLFLRALpSPSSALRLFTARR
|   . ..||| ||. ||. || ||. ||.  . | |. .|..|. .||
ldekg.gpvlV.HCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR

0048179 (Phosphotyrosine protein) phosphatases II 474-568 7.8e-12 40.6 In-house 31-125 (144) alignment
Range on Protein: 474-568
Range on HMM: 31-125/144.0
YLVFNLSGEQYDTDQLSG--QVVDYEWPNRAMPPL-ESLVELCRQLDSWLRADfkNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRL
..|.||. | . ..      |.. . ||..  |.| | | |... ....|. .  .. ..||. ||. .| ||. ||....   |. .||.|. .|| 
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkklg.lsleealalvrsrrp

0043336 (Phosphotyrosine protein) phosphatases II 438-567 2.2e-11 39.2 In-house 87-256 (278) alignment
Range on Protein: 438-567
Range on HMM: 87-256/278.0
TSRILVMSYPFEEggvgrpnvlkE--------------------------------------------VAAYLEGTHPSQYLVFNLSGE--QYDTDQLSG
. .......| .|                                                       .  .|. .| . | |..|  .  ...  .   
prkfiatqgPlpe..........tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvt

QVVDYEWPNRAMP-PLESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFTARR
..  . ||    | .|..|..........|. | ......||..||. .| ... |||.     .  ... .|.. .  .|
hyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR

0045098 (Phosphotyrosine protein) phosphatases II 466-567 2.4e-11 39.0 In-house 131-250 (278) alignment
Range on Protein: 466-567
Range on HMM: 131-250/278.0
LEGTHPSQYLVFNLSGEQYDTDQLSGQVVDY-EWPNRAMPPLE---SLVELCRQLDSWLR------------ADFKNVLVIHCKDGVHPSGILVVSYLLF
|.  .   .|| ||. |..|  ..  ....|  ||    |.|.   |. ||.......|.             | ... ..||. ||. .| ||. ||. 
lddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylml

LR--ALPSPSSALRLFTARR
 .     .. .|.. .  .|
elleggvdlleavkelrsqR

0049260 (Phosphotyrosine protein) phosphatases II 462-567 6.7e-11 37.6 In-house 25-129 (152) alignment
Range on Protein: 462-567
Range on HMM: 25-129/152.0
VAAYLEGTHPSQYLVFNLSGEQ-YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVIHCKDGVHPSGILVVSYLLFlrALPSPSSAL
.  .|   . . ... .   |  ..      |.  . ||    |.|. |.. . ... .|. | ... ..||. ||  .| ||. ||.      |.  |.
fwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..lgvsleeav

RLFTARR
.|. ..|
alvrekR

0045450 (Phosphotyrosine protein) phosphatases II 464-567 9.7e-11 37.4 In-house 168-283 (307) alignment
Range on Protein: 464-567
Range on HMM: 168-283/307.0
AYLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEW---PNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLRAL-----
 .|. .| . | |..|  . .| .. | .|  . .   |.   || .|.|..........|...  ... ..||..||  .| ... ||.  .       
tllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtl

--PSPSSALRLFTARR
  ... .|..|. ..|
ldvdlleavkllreqR

0046845 (Phosphotyrosine protein) phosphatases II 436-567 2.2e-10 35.8 In-house 74-253 (284) alignment
Range on Protein: 436-567
Range on HMM: 74-253/284.0
YVTSRILVMSYPFEE-------------------------GG-----VGRPNVlKEVAAY-------LEGTHPSQYLVFNLSGEQYDTDQLSGQVVDY--
|.. .......| ..                          |       .|.  .||  |       |. .. . | |..|. . ..... | .|  .  
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhy

-EWPNRAMPP-LESLVELCRQLDSWLRA-DFKNVLVIHCKDGVHPSGILVVSYLLFLRA-------LPSPSSALRLFTARR
 .||..  || .|.|.|..|.....|.. . ... |.||..||  .| ... .||. .         ... .|.. .  .|
tswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR

0040439 (Phosphotyrosine protein) phosphatases II 466-567 5e-10 34.9 In-house 116-225 (249) alignment
Range on Protein: 466-567
Range on HMM: 116-225/249.0
LEGTHPSQYLVFNLSGEQ-YDTDQLSGQVVDY-EWPNRAMP-PLESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPS
|. .. . | |..|  .  || . .  ... |  ||    |  .|.|..........|...  ......||..||. .|.... ||..     .   .. 
lsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdle

SALRLFTARR
.|..|.  .|
eavkllrsqR

0040438 (Phosphotyrosine protein) phosphatases II 476-567 2.9e-09 32.1 In-house 160-255 (317) alignment
Range on Protein: 476-567
Range on HMM: 160-255/317.0
VFNLSGEQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLLF-----LRaLPSPSSALRLFTARR
.. ... . ..     .     ||    || ...|..........|. | ......||..||. .| ... ||..      .  ... .|.. . ..|
tlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqR

0051299 (Phosphotyrosine protein) phosphatases II 470-551 3.9e-09 31.8 In-house 158-245 (288) alignment
Range on Protein: 470-551
Range on HMM: 158-245/288.0
HPSQYLVFNLSGE------QYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLLFLR
. . | |..|  .      . .. .   .   . ||.  .|. .|.|....|.....|. . ... |.||..||  .| ... .||. .
vlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleq

0047943 (Phosphotyrosine protein) phosphatases II 473-567 5.1e-09 31.4 In-house 149-251 (273) alignment
Range on Protein: 473-567
Range on HMM: 149-251/273.0
QYLVFNLSGE--QYDTDQLSGQVVDYEWPNRAMP-PLESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFT
 | |..|  .  ...      ..  ..||.   |  ||||.|........|.|.  ... |.||..||  .| ... .||.     .  ... .|..|. 
dytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllr

ARR
 .|
sqR

0036941 (Phosphotyrosine protein) phosphatases II 492-567 7.6e-08 27.5 In-house 172-256 (297) alignment
Range on Protein: 492-567
Range on HMM: 172-256/297.0
QVVDYEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLRAL-------PSPSSALRLFTARR
.     ||   .|.  .||..........|..   ... ..||..||. || ... .|.. .         ... .|.. .  .|
hfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqR

PTPc_DSPc_SM00012 496-551 9e-07 24.4 In-house 8-65 (105) alignment
Range on Protein: 496-551
Range on HMM: 8-65/105.0
YEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLR
..||.  .|   .|..||.|..... ..   .. .|.||..||  .|..|. ..|  .
tgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq

0050432 (Phosphotyrosine protein) phosphatases II 496-549 9.1e-07 24.0 In-house 205-256 (308) alignment
Range on Protein: 496-549
Range on HMM: 205-256/308.0
YEWPNRAMPP-LESLVELCRQLDSWLradFKNVLVIHCKDGVHPSGILVVSYLLF
  ||.   || .|.|..........|    ... |.||..||  .| ... .||.
tnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdlll