Gene Auxilin-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Auxilin
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP039_AA protein Get Run
AqueP039_AA_424-576 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Auxilin_pd Subfamily Auxilin 428-582 2.6e-66 215.4 In-house 5-155 (166) alignment 
Range on Protein: 428-582
Range on HMM: 5-155/166.0
KQKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNV
 ....||.|.||||.|||.|.|. .....|....|...||..||..|||.|||...|.|..||..||...||.|..|.||||||.||.|.|||..|.|||
akndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknv

LVIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGqgmdISPSDRR
.|.|||||...|..||...|.|.|.|..|.||.|||...|||.|    .|||..|
vvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig....lspsekr
subfamily_Tensin_pd Subfamily Tensin 429-582 1.8e-38 124.9 In-house 8-162 (189) alignment 
Range on Protein: 429-582
Range on HMM: 8-162/189.0
QKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVL
.   |.||.|.||...|.| |       . ||.||. |.  | ..|||||||  .|| ..|. .|.|. ||.   |.|| |  .|..|||||.|| .||.
kvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvv

VIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQG-MDISPSDRR
|.||| |    |..| .|. . .   | ..||  |. .|. . .   .. || ||
vvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrr
subfamily_PTEN_pd Subfamily PTEN 431-582 1.4e-33 111.4 In-house 19-170 (184) alignment 
Range on Protein: 431-582
Range on HMM: 19-170/184.0
STDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNL-SGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLV
  |..|.|..|..|.|| |.      | |..|  .|| .|  .| ..|| |...||.....|.|  |.  .   |||| | |.......|| .| ||| |
dLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvv

IHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQGMDIsPSDRR
.||| |   .|.|.|.|||  . |.....||.||.. |  ...|. | || ||
vHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvti.PsqrR
Pkinase Protein kinase domain 239-392 3.3e-33 104.9 Pfam-A 2-148 (260) alignment 
Range on Protein: 239-392
Range on HMM: 2-148/260.0
KVKKVIAEGGYGFVFVAQDTSTGIDYALKRQIVASENIKAIKQ---EITFLTQLsGHPHIIHFIGAASSkdpaggSAEFLIVTELITGGELVDIVN-TRS
.... . .|..| |. |.. .||  .|.|.    .|. |. |.   |.  |..|  ||.|......  .      . |...|.|.. ||.| |...  . 
elleklGsGsfGkVykakekktgkkvAvKilkkeeekskkektalrElkilkkl.nHpnivkllevfee......kdelylvleyveggdlfdllkkkgk

LSPHQVLRVFYETCQAIAHMHSQtpPIIHRDIKVgvENLLLTDKGSVKLCDFGSATTQ
|| ... .............||.   |||||.|   ||.||..||..|..|||.| . 
lseeeikkialqilegleylHsn..giiHrDLKp..eNiLldekgelkiaDFGlakkl
subfamily_VSP_pd Subfamily VSP 432-572 2.3e-26 87.0 In-house 34-175 (212) alignment 
Range on Protein: 432-572
Range on HMM: 34-175/212.0
TDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNLSGE-QYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVI
 |.|||| ||. ||.|         | ..||| .|.  |. .| |.||  | .||   .  .|.     .  .| || |. .....  || .| ||||.|
ldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvlai

HCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQ
||| |   .| .| ..||   .. .   .|  |. ||  ...
hckGGkgrtGtivcalllaseifetakesldyfgerrtdkte
PTEN_1 429-571 9.1e-23 76.1 In-house 17-175 (196) alignment 
Range on Protein: 429-571
Range on HMM: 17-175/196.0
QKSTDITYVTSRILVMSYPFEEG------GVGRPNVLKEVAAYLEGTHPSQ-YLVFNLSGEQ------YDTDQ---LSGQVVDYEWPNRAMPPLESLVEL
 . .|.||.||||..|.... ..      .    . ||.|||.|.  ...  .||.||| |       || ..      .. .....    |.|..| . 
telldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdi

CRQLDSWLRADF-KNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRLPEG
|.....||..|  .|| ..||| |.  || .| .||....   ..  ||.|. ..| | .
cksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppga
Pkinase_Tyr Protein tyrosine kinase 238-392 2e-22 69.4 Pfam-A 1-153 (259) alignment 
Range on Protein: 238-392
Range on HMM: 1-153/259.0
LKVKKVIAEGGYGFVFVAQDT----STGIDYALKRQ--IVASENIKAIKQEITFLTQLsGHPHIIHFIGAASSKDPaggsaeFLIVTELITGGELVDIVN
|...| ..|| .| |. .. .    .. .. |.|       .|. ... .|......|  |..|....|. ....|      .|||||...||.| . ..
lelgkklGeGafGeVvegtlkgekekkevkVavKtlkeeaeeeekeefleeakimkkl.khenivkllgvctkeep......llivteyvegGdLlkfLr

TR---SLSPHQVLRVFYETCQAIAHMHSQTppIIHRDIKvgVENLLLTDKGSVKLCDFGSATTQ
..   .|. ...|.. .. ........|..  ..|||.     | ||.... ||..||| | . 
kkekekltledllsfalqiAkGmeyLeskk..lvHrdLa..arNvLleenkvvkisDfGLardi
0036282 (Phosphotyrosine protein) phosphatases II 433-567 1.7e-21 72.2 In-house 11-146 (174) alignment 
Range on Protein: 433-567
Range on HMM: 11-146/174.0
DITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNLSGEQ-YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVIH
|..|.|.|......|..     . . .. |  .||  ..  |...|.  |  .|  .|  |.... || . .|.|. | |........|  | ......|
dlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVH

CKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARR
|. ||. .|.||. ||.  . |.|.  ||.|. ..|
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelR
0038934 (Phosphotyrosine protein) phosphatases II 436-567 1.7e-17 59.2 In-house 15-156 (194) alignment 
Range on Protein: 436-567
Range on HMM: 15-156/194.0
YVTSRILVMSYPFEEGGVGRP-----NVLKEVAAYLEGTHPSQYLVFNLS--GEQYDTDQLSG---QVVDYEWPNR-AMPPLESLVELCRQLDSWLRADF
..| |......| ..    .      . .. .  ||.  .   .|| .|.  .  ||.. . .   ..... .|.. . |.|| | . .. .| .|..| 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

KNVLVIHCKDGVHPSGILVVSYLLFLRALpSPSSALRLFTARR
..| ..||| |.  .|.||..||.  . . |.  |..||. .|
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR
0041856 (Phosphotyrosine protein) phosphatases II 430-576 2.4e-15 52.1 In-house 15-155 (182) alignment 
Range on Protein: 430-576
Range on HMM: 15-155/182.0
KSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQY-LVFNLSGEQYDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSwlradFK
 | |..|.. .....|.|. .  .   . |..||..|.  .  .. .. ||..|.|. . |     |.... ||    |.|..|......  .      .
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eg

NVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRlpegQGMDI
.. ..||. ||. .| ||. ||.  .   |. .|..|.  ||     || |
gpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR....pgmvi
0043147 (Phosphotyrosine protein) phosphatases II 433-568 2.7e-14 48.7 In-house 14-141 (172) alignment 
Range on Protein: 433-568
Range on HMM: 14-141/172.0
DITYVTSRILVMSYPfeeggvgRPNVLKEVAAYLEGTHPSQylVFNLSGEQYDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLV
|..|.. |.... .|        .| | .. ..|   . .   ..|| ...||...|.    |.  . ||    |.|| | |.....|..|  . ... .
dlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvl

IHCKDGVHPSGILVVSYLLFlRALpSPSSALRLFTARRL
.||. ||  .| ||. ||.  . | |.  |..|. ..| 
VHCsaGvgRtgtlvaaylml.lgl.sleeavalvrekRp
0046846 (Phosphotyrosine protein) phosphatases II 431-568 4e-14 48.2 In-house 9-152 (176) alignment 
Range on Protein: 431-568
Range on HMM: 9-152/176.0
STDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGthpSQYLVFNLSGEQ-----------YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSW
  |..|.. .....|.|    |  . .. . .. ..|      ..|.||  |.            .  .|. |.  . ||    |.|| | ||.......
dldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirea

LRADfkNVLVIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRL
|...  .. ..||. |.  .| ||. ||| |.   |.  ||.|. ..| 
lkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRp
0039614 (Phosphotyrosine protein) phosphatases II 432-567 2.8e-13 45.4 In-house 83-268 (297) alignment 
Range on Protein: 432-567
Range on HMM: 83-268/297.0
TDITYV-----------TSRILVMSYPFEEggvgrpnvlkEVA-------------------------------------------AYLEGTHPSQYLVF
 | .|.           | .......| .|           |.                                            .|. .| . | |.
ldsdYinAsyvdgydlltrkfIatqgPlpe..........tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvr

NLSGEQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFTARR
.|. . ..      ..  . ||    || ||.| |........|...  ... ..||..||. .| ... ||..     .  ... .|.. .  .|
tlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR
0037934 (Phosphotyrosine protein) phosphatases II 433-568 6.5e-13 44.3 In-house 38-221 (243) alignment 
Range on Protein: 433-568
Range on HMM: 38-221/243.0
DITYVTSRILVMSYPFEEGGVG----RPNVLKEV---------------------------------AAYLEGTHPSQYLVFNLSGEQY---DTDQLSGQ
. .||| |. ....| .|          . |.|                                    .|. .| ..| |..|. | .   |  .|  .
nliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvih

VVDYEWPNRAMPP-LESLVELCRQLDSWLRA-------DFKNVLVIHCKDGVHPSGILVVSYLLFLR-AlPSPSSALRLFTARRL
.  . ||   .|.  |.|....... .....       | ......||. ||. .| |.. ||. |.    .. .|..|. ..| 
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg.vdleeavkllreqRp
0049772 (Phosphotyrosine protein) phosphatases II 428-568 8e-13 44.2 In-house 49-255 (314) alignment 
Range on Protein: 428-568
Range on HMM: 49-255/314.0
KQKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVAAYLEGTHPSQYLVFNLS-----------------------------------------------
|. ..||  . .|  . ..|..  .    . .. . ...   .|... |....                                               
knryldilpadnrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpl

-------------------GEQYDTDQLSGQVVDY---EWPNRAMPPLESLVELCRQLDSWlraDFKNVLVIHCKDGVHPSGI-LVVSYLLFLRALpSPS
                   .|.|| . ...... |    .|    |.|| . |... ....   | ......|||.|.. .|  .|. ||. |. . |. 
lildgngneptaadlellkeelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sle

SALRLFTARRL
 ||. . ..| 
ealedvrlkRp
0042113 (Phosphotyrosine protein) phosphatases II 438-567 1.1e-12 43.4 In-house 51-222 (245) alignment 
Range on Protein: 438-567
Range on HMM: 51-222/245.0
TSRILVMSYPFEEggvgrpnvlkEVA---------------------------------------------AYLEGTHPSQYLVFNLSGE--QYDTDQLS
| .......| .|           |.                                              .|. .| . | |..|. .  ..|  .  
tpkfiatqgPlpe..........tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrev

GQVVDYEWPNRAMPP-LESLVELCRQLDSWLRADFKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFTARR
 ..  . ||   .|. ||.|..... ....|..| ......||..||. .| ... ||..     .   |. .|.. .  .|
ihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR
0051082 (Phosphotyrosine protein) phosphatases II 432-568 1.7e-12 42.7 In-house 6-133 (151) alignment 
Range on Protein: 432-568
Range on HMM: 6-133/151.0
TDITYVTSRILVMSYPFEeggvgrpnvlkEVAAYLegTHPSQYLVFNLSGEQ---YDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSWLRADFK
....|||........| .           .. ..|   .   . ..|| .|.   |... |     .|... ...   |.|. . . .... ..|... .
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVLVIHCKDGVHPSGILVVSYLLFLRalPSPSSALRLFTARRL
.....||. |.. .|.||. ||. |.   |. .||. . ..| 
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp
0048076 (Phosphotyrosine protein) phosphatases II 474-568 2.6e-12 42.1 In-house 31-123 (145) alignment 
Range on Protein: 474-568
Range on HMM: 31-123/145.0
YLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPL-ESLVELCRQLDSWLRADfkNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRL
..|.||. |...  .|  |.. . || .  |.| | | |........|...  .. ..||. ||. .| ||. ||..|.   |. .||.|. ..| 
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllg.vsleealelvrsqrp
0044763 (Phosphotyrosine protein) phosphatases II 430-567 2.9e-12 42.1 In-house 19-151 (178) alignment 
Range on Protein: 430-567
Range on HMM: 19-151/178.0
KSTDITYVTSRILVMSYPFeeggvgrpnvlKEVAAYLEGTHPSqyLVFNLSG---------EQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSW
  ....... .....|.|             .  ..|   . .  .. ||..          .|. .. . |.. . .|    |. || . |... ....
dyinaseilpglylgslpp...........addlellkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieea

LR-ADfKNVLViHCKDGVHPSGILVVSYLLFLRALpSPSSALRLFTARR
|   . ..||| ||. ||. || ||. ||.  . | |. .|..|. .||
ldekg.gpvlV.HCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR
0048179 (Phosphotyrosine protein) phosphatases II 474-568 7.8e-12 40.6 In-house 31-125 (144) alignment 
Range on Protein: 474-568
Range on HMM: 31-125/144.0
YLVFNLSGEQYDTDQLSG--QVVDYEWPNRAMPPL-ESLVELCRQLDSWLRADfkNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRL
..|.||. | . ..      |.. . ||..  |.| | | |... ....|. .  .. ..||. ||. .| ||. ||....   |. .||.|. .|| 
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkklg.lsleealalvrsrrp
0043336 (Phosphotyrosine protein) phosphatases II 438-567 2.2e-11 39.2 In-house 87-256 (278) alignment 
Range on Protein: 438-567
Range on HMM: 87-256/278.0
TSRILVMSYPFEEggvgrpnvlkE--------------------------------------------VAAYLEGTHPSQYLVFNLSGE--QYDTDQLSG
. .......| .|                                                       .  .|. .| . | |..|  .  ...  .   
prkfiatqgPlpe..........tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvt

QVVDYEWPNRAMP-PLESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFTARR
..  . ||    | .|..|..........|. | ......||..||. .| ... |||.     .  ... .|.. .  .|
hyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR
0045098 (Phosphotyrosine protein) phosphatases II 466-567 2.4e-11 39.0 In-house 131-250 (278) alignment 
Range on Protein: 466-567
Range on HMM: 131-250/278.0
LEGTHPSQYLVFNLSGEQYDTDQLSGQVVDY-EWPNRAMPPLE---SLVELCRQLDSWLR------------ADFKNVLVIHCKDGVHPSGILVVSYLLF
|.  .   .|| ||. |..|  ..  ....|  ||    |.|.   |. ||.......|.             | ... ..||. ||. .| ||. ||. 
lddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylml

LR--ALPSPSSALRLFTARR
 .     .. .|.. .  .|
elleggvdlleavkelrsqR
0049260 (Phosphotyrosine protein) phosphatases II 462-567 6.7e-11 37.6 In-house 25-129 (152) alignment 
Range on Protein: 462-567
Range on HMM: 25-129/152.0
VAAYLEGTHPSQYLVFNLSGEQ-YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVIHCKDGVHPSGILVVSYLLFlrALPSPSSAL
.  .|   . . ... .   |  ..      |.  . ||    |.|. |.. . ... .|. | ... ..||. ||  .| ||. ||.      |.  |.
fwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..lgvsleeav

RLFTARR
.|. ..|
alvrekR
0045450 (Phosphotyrosine protein) phosphatases II 464-567 9.7e-11 37.4 In-house 168-283 (307) alignment 
Range on Protein: 464-567
Range on HMM: 168-283/307.0
AYLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEW---PNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLRAL-----
 .|. .| . | |..|  . .| .. | .|  . .   |.   || .|.|..........|...  ... ..||..||  .| ... ||.  .       
tllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtl

--PSPSSALRLFTARR
  ... .|..|. ..|
ldvdlleavkllreqR
0046845 (Phosphotyrosine protein) phosphatases II 436-567 2.2e-10 35.8 In-house 74-253 (284) alignment 
Range on Protein: 436-567
Range on HMM: 74-253/284.0
YVTSRILVMSYPFEE-------------------------GG-----VGRPNVlKEVAAY-------LEGTHPSQYLVFNLSGEQYDTDQLSGQVVDY--
|.. .......| ..                          |       .|.  .||  |       |. .. . | |..|. . ..... | .|  .  
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhy

-EWPNRAMPP-LESLVELCRQLDSWLRA-DFKNVLVIHCKDGVHPSGILVVSYLLFLRA-------LPSPSSALRLFTARR
 .||..  || .|.|.|..|.....|.. . ... |.||..||  .| ... .||. .         ... .|.. .  .|
tswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR
0040439 (Phosphotyrosine protein) phosphatases II 466-567 5e-10 34.9 In-house 116-225 (249) alignment 
Range on Protein: 466-567
Range on HMM: 116-225/249.0
LEGTHPSQYLVFNLSGEQ-YDTDQLSGQVVDY-EWPNRAMP-PLESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPS
|. .. . | |..|  .  || . .  ... |  ||    |  .|.|..........|...  ......||..||. .|.... ||..     .   .. 
lsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdle

SALRLFTARR
.|..|.  .|
eavkllrsqR
0040438 (Phosphotyrosine protein) phosphatases II 476-567 2.9e-09 32.1 In-house 160-255 (317) alignment 
Range on Protein: 476-567
Range on HMM: 160-255/317.0
VFNLSGEQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLLF-----LRaLPSPSSALRLFTARR
.. ... . ..     .     ||    || ...|..........|. | ......||..||. .| ... ||..      .  ... .|.. . ..|
tlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqR
0051299 (Phosphotyrosine protein) phosphatases II 470-551 3.9e-09 31.8 In-house 158-245 (288) alignment 
Range on Protein: 470-551
Range on HMM: 158-245/288.0
HPSQYLVFNLSGE------QYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLLFLR
. . | |..|  .      . .. .   .   . ||.  .|. .|.|....|.....|. . ... |.||..||  .| ... .||. .
vlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleq
0047943 (Phosphotyrosine protein) phosphatases II 473-567 5.1e-09 31.4 In-house 149-251 (273) alignment 
Range on Protein: 473-567
Range on HMM: 149-251/273.0
QYLVFNLSGE--QYDTDQLSGQVVDYEWPNRAMP-PLESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFT
 | |..|  .  ...      ..  ..||.   |  ||||.|........|.|.  ... |.||..||  .| ... .||.     .  ... .|..|. 
dytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllr

ARR
 .|
sqR
0036941 (Phosphotyrosine protein) phosphatases II 492-567 7.6e-08 27.5 In-house 172-256 (297) alignment 
Range on Protein: 492-567
Range on HMM: 172-256/297.0
QVVDYEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLRAL-------PSPSSALRLFTARR
.     ||   .|.  .||..........|..   ... ..||..||. || ... .|.. .         ... .|.. .  .|
hfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqR
PTPc_DSPc_SM00012 496-551 9e-07 24.4 In-house 8-65 (105) alignment 
Range on Protein: 496-551
Range on HMM: 8-65/105.0
YEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLR
..||.  .|   .|..||.|..... ..   .. .|.||..||  .|..|. ..|  .
tgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq
0050432 (Phosphotyrosine protein) phosphatases II 496-549 9.1e-07 24.0 In-house 205-256 (308) alignment 
Range on Protein: 496-549
Range on HMM: 205-256/308.0
YEWPNRAMPP-LESLVELCRQLDSWLradFKNVLVIHCKDGVHPSGILVVSYLLF
  ||.   || .|.|..........|    ... |.||..||  .| ... .||.
tnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdlll