Gene Auxilin-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Auxilin
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP040_AA protein Get Run
AqueP040_AA_392-557 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Auxilin_pd Subfamily Auxilin 396-558 4.2e-71 231.0 In-house 5-163 (166) alignment 
Range on Protein: 396-558
Range on HMM: 5-163/166.0
KQKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNV
 ....||.|.||||.|||.|.|. .....|....|...||..||..|||.|||...|.|..||..||...||.|..|.||||||.||.|.|||..|.|||
akndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknv

LVIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGqgmdISPSDRRYLNYMMAL
.|.|||||...|..||...|.|.|.|..|.||.|||...|||.|    .|||..|||.|...|
vvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig....lspsekryleyladl
Pkinase Protein kinase domain 42-309 1.4e-49 158.6 Pfam-A 2-257 (260) alignment 
Range on Protein: 42-309
Range on HMM: 2-257/260.0
KVKKVIAEGGYGFVFVAQDTSTGIDYALKRQIVASENIKAIKQ---EITFLTQLsGHPHIINFIGAASSkdpaggSAEFLIVTELITGGELVDIVN-TRP
.... . .|..| |. |.. .||  .|.|.    .|. |. |.   |.  |..|  ||.|......  .      . |...|.|.. ||.| |...  ..
elleklGsGsfGkVykakekktgkkvAvKilkkeeekskkektalrElkilkkl.nHpnivkllevfee......kdelylvleyveggdlfdllkkkgk

LSPRQVLRVFYETCQAIAHMHSQtpPIIHRDIKVgvENLLLTDKGSVKLCDFGSATTQrltpdhswsatqRGLTEDEIQANTTPMYRAPEMIDlySNYPI
|| ... .............||.   |||||.|   ||.||..||..|..|||.| .                 |.  .   |. |.|||..   ..  .
lseeeikkialqilegleylHsn..giiHrDLKp..eNiLldekgelkiaDFGlakkl............eksseklttlvgtreYmAPEvll..kakey

NEKGDIWALGCLLYKLCFQEHPFEDS---AKLRILNANYHIPPGDNVY------KEFHNIIRSCLVVDPTKRPSVDSIVAQ
 .| |.|.||..||.|.... ||...    .|...... . .   . .      .|. ..|...|  ||.||.....|. .
tkkvDvWslGvilyelltgklpfsgeseedqlelirkilkkkleedepkssskseelkdlikkllekdpakRltaeeilkh
subfamily_Tensin_pd Subfamily Tensin 397-558 2.2e-41 134.4 In-house 8-170 (189) alignment 
Range on Protein: 397-558
Range on HMM: 8-170/189.0
QKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVL
.   |.||.|.||...|.| |       . ||.|.. |.  | ..|||||||  .|| ..|. .|.|. ||.   |.|| |  .|..|||||.|| .||.
kvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvv

VIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQG-MDISPSDRRYLNYMMAL
|.||| |    |..| .|. . .   | ..||  |. .|. . .   .. || |||..|. .|
vvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsgl
subfamily_PTEN_pd Subfamily PTEN 399-558 7.7e-37 122.0 In-house 19-178 (184) alignment 
Range on Protein: 399-558
Range on HMM: 19-178/184.0
STDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNL-SGEQYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLV
  |..|.|..|..|.|| |.      | |..|  .|| .|  .| ..|| |...||.....|.|  |.  .   |||| | |.......|| .| ||| |
dLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvv

IHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQGMDIsPSDRRYLNYMMAL
.||| |   .|.|.|.|||  . |.....||.||.. |  ...|. | || |||..|. .|
vHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvti.PsqrRYveYyekl
Pkinase_Tyr Protein tyrosine kinase 41-310 1e-33 106.4 Pfam-A 1-259 (259) alignment 
Range on Protein: 41-310
Range on HMM: 1-259/259.0
LKVKKVIAEGGYGFVFVAQDT----STGIDYALKRQ--IVASENIKAIKQEITFLTQLsGHPHIINFIGAASSKDPaggsaeFLIVTELITGGELVDIVN
|...| ..|| .| |. .. .    .. .. |.|       .|. ... .|......|  |..|....|. ....|      .|||||...||.| . ..
lelgkklGeGafGeVvegtlkgekekkevkVavKtlkeeaeeeekeefleeakimkkl.khenivkllgvctkeep......llivteyvegGdLlkfLr

TR---PLSPRQVLRVFYETCQAIAHMHSQTppIIHRDIKvgVENLLLTDKGSVKLCDFGSATTQrltpdhswsaTQRGLTEDEIQANTTPMYRAPEMIDL
..   .|. ...|.. .. ........|..  ..|||.     | ||.... ||..||| | .           ...  .... .|..   . |||... 
kkekekltledllsfalqiAkGmeyLeskk..lvHrdLa..arNvLleenkvvkisDfGLardi..........ekddyykkkekaklpvkWmapEslke

YSnypINEKGDIWALGCLLYKLCF-QEHPFEDSAKLR---ILNANYHIPPGDNVYKEFHNIIRSCLVVDPTKRPSVDSIVAQL
 .   ...| |.|. | ||. ..   |.|...  . .    |.......  .|. .|.......|.  .|.|||. ...| .|
kk...ftsksDvWsfGvllwEiftlgespypglsneevleklkegkrlekpencpeelyelmkqCweeepekRptfkelvekl
subfamily_VSP_pd Subfamily VSP 400-557 2.1e-27 90.5 In-house 34-196 (212) alignment 
Range on Protein: 400-557
Range on HMM: 34-196/212.0
TDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNLSGE-QYDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVI
 |.|||| ||. ||.|         | ..||. .|.  |. .| |.||  | .||   .  .|.     .  .| || |. .....  || .| ||||.|
ldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvlai

HCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQGMDI----SPSDRRYLNYMMA
||| |   .| .| ..||   .. .   .|  |. ||  ...|       .||..||..|.  
hckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleq
PTEN_1 397-555 1.5e-24 81.9 In-house 17-188 (196) alignment 
Range on Protein: 397-555
Range on HMM: 17-188/196.0
QKSTDITYVTSRILVMSYPFEEG------GVGRPNVLKEVSAYLEGTHPSQ-YLVFNLSGEQ------YDTDQ---LSGQVVDYEWPNRAMPPLESLVEL
 . .|.||.||||..|.... ..      .    . ||.|.|.|.  ...  .||.||| |       || ..      .. .....    |.|..| . 
telldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdi

CRQLDSWLRADF-KNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRLPEGQGmdiSPSDRRYLNYM
|.....||..|  .|| ..||| |.  || .| .||....   ..  ||.|. ..| | .     ||| .|.|.| 
cksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn...spsqerlleyf
0036282 (Phosphotyrosine protein) phosphatases II 401-554 9.1e-22 73.0 In-house 11-164 (174) alignment 
Range on Protein: 401-554
Range on HMM: 11-164/174.0
DITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNLSGEQ-YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVIH
|..|.|.|......|..     . . .. |  .||  ..  |...|.  |  .|  .|  |.... || . .|.|. | |........|  | ......|
dlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVH

CKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPeGQGMDISPSDRRYLNY
|. ||. .|.||. ||.  . |.|.  ||.|. ..||    || ..|| .|.| |
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq.rpgmvqtpsQyrflyy
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 567-709 4.1e-19 60.1 Pfam-A 2-133 (134) alignment 
Range on Protein: 567-709
Range on HMM: 2-133/134.0
HPHSFKLTGLNLTSVPIYnEARNGCKPFVEVFVDGERVHtsCNKENMDKLKEYTTKDGQISIPLNTTVYGNLLIIVHHIKSVpltkraemGMSAVKMFKF
.| ...|... | ..| . . |.||||.|.|.   . |    ....  . .|. .|.  . .| . .|.|  |. ..| .|          ... |.|..
npkrlelksiilegiPnf.ktrggckpkvkvyngkkkvf..kelasykdsterraktfivkepnrlpveGDvlveflhkdsk........lpkkekifrv

QIHTGFLSTKMTSLTLEKNELDGSAVKKTDRFPSSFKVLLNFS
...| |.... . |||.|||||.   .| ..|.. ||| | |.
wFNTsFieknqnvltlpkneLDkalkdkdkkfsknfkvelvfe
0038934 (Phosphotyrosine protein) phosphatases II 404-546 1.6e-17 59.2 In-house 15-157 (194) alignment 
Range on Protein: 404-546
Range on HMM: 15-157/194.0
YVTSRILVMSYPFEEGGVGRP-----NVLKEVSAYLEGTHPSQYLVFNLS--GEQYDTDQLSG---QVVDYEWPNR-AMPPLESLVELCRQLDSWLRADF
..| |......| ..    .      . .. .  ||.  .   .|| .|.  .  ||.. . .   ..... .|.. . |.|| | . .. .| .|..| 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

KNVLVIHCKDGVHPSGILVVSYLLFLRALpSPSSALRLFTARRlpegqgmdisP
..| ..||| |.  .|.||..||.  . . |.  |..||. .|          |
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR..........p
0041856 (Phosphotyrosine protein) phosphatases II 398-557 8.7e-16 53.5 In-house 15-168 (182) alignment 
Range on Protein: 398-557
Range on HMM: 15-168/182.0
KSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQY-LVFNLSGEQYDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSwlradFK
 | |..|.. .....|.|. .  .   . |..| ..|.  .  .. .. ||..|.|. . |     |.... ||    |.|..|......  .      .
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eg

NVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRlpegQGMDISPSDRRYLNYMMA
.. ..||. ||. .| ||. ||.  .   |. .|..|.  ||     || |.|.  ..| ... 
gpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR....pgmvitpnqyfflqlall
0046846 (Phosphotyrosine protein) phosphatases II 399-556 2.7e-14 48.8 In-house 9-169 (176) alignment 
Range on Protein: 399-556
Range on HMM: 9-169/176.0
STDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGthpSQYLVFNLSGEQ-----------YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSW
  |..|.. .....|.|    |  . .. . .  ..|      ..|.||  |.            .  .|. |.  . ||    |.|| | ||.......
dldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirea

LRADfkNVLVIHCKDGVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPegqGMDISPSDRRYLNYMM
|...  .. ..||. |.  .| ||. ||| |.   |.  ||.|. ..| .   |.  .|. .|.| ...
lkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl...gavqtpeQyrflyefe
0043147 (Phosphotyrosine protein) phosphatases II 401-553 2.8e-14 48.7 In-house 14-154 (172) alignment 
Range on Protein: 401-553
Range on HMM: 14-154/172.0
DITYVTSRILVMSYPfeeggvgRPNVLKEVSAYLEGTHPSQylVFNLSGEQYDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLV
|..|.. |.... .|        .| | .. ..|   . .   ..|| ...||...|.    |.  . ||    |.|| | |.....|..|  . ... .
dlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvl

IHCKDGVHPSGILVVSYLLFlRALpSPSSALRLFTARRlpegQGMDISPSDRRYLN
.||. ||  .| ||. ||.  . | |.  |..|. ..|     |.  .|| .|.| 
VHCsaGvgRtgtlvaaylml.lgl.sleeavalvrekR....pgavqnpsqyrfly
0039614 (Phosphotyrosine protein) phosphatases II 400-556 8.6e-14 47.1 In-house 83-285 (297) alignment 
Range on Protein: 400-556
Range on HMM: 83-285/297.0
TDITYV-----------TSRILVMSYPFEEggvgrpnvlkevS---------------------------------------------AYLEGTHPSQYL
 | .|.           | .......| .|            .                                              .|. .| . | 
ldsdYinAsyvdgydlltrkfIatqgPlpe............tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgyt

VFNLSGEQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFTARRlp
|..|. . ..      ..  . ||    || ||.| |........|...  ... ..||..||. .| ... ||..     .  ... .|.. .  .|  
vrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR..

egQGMDISPSDRRYLNYMM
   |.  .||  |.| ...
..pgavqtpsqyrflydal
0037934 (Phosphotyrosine protein) phosphatases II 401-556 3.1e-13 45.3 In-house 38-238 (243) alignment 
Range on Protein: 401-556
Range on HMM: 38-238/243.0
DITYVTSRILVMSYPFEEGGVG----RPNVLKEVS---------------------------------AYLEGTHPSQYLVFNLSGEQYD---TDQLSGQ
. .||| |. ....| .|          . |.|                                    .|. .| ..| |..|. | .|     .|  .
nliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvih

VVDYEWPNRAMPP-LESLVELCRQLDSWLRA-------DFKNVLVIHCKDGVHPSGILVVSYLLFLR-AlPSPSSALRLFTARRLPegqGMDISPSDRRY
.  . ||   .|.  |.|....... .....       | ......||. ||. .| |.. ||. |.    .. .|..|. ..|      .  .|| .|.
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg.vdleeavkllreqRpg...kavqtpsqyrf

LNYMM
| ...
lyeal
0042113 (Phosphotyrosine protein) phosphatases II 433-556 6e-13 44.2 In-house 113-239 (245) alignment 
Range on Protein: 433-556
Range on HMM: 113-239/245.0
YLEGTHPSQYLVFNLSGE--QYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRADFKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPS
.|. .| . | |..|. .  ..|  .   ..  . ||   .|. ||.|..... ....|..| ......||..||. .| ... ||..     .   |. 
llseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsle

SALRLFTARRlpegQGMDISPSDRRYLNYMM
.|.. .  .|     |.  .||  |.| ...
eavkelrsqR....pgavqtpsqyrflyeal
0049772 (Phosphotyrosine protein) phosphatases II 396-536 1.6e-12 43.3 In-house 49-255 (314) alignment 
Range on Protein: 396-536
Range on HMM: 49-255/314.0
KQKSTDITYVTSRILVMSYPFEEGGVGRPNVLKEVSAYLEGTHPSQYLVFNLS-----------------------------------------------
|. ..||  . .|  . ..|..  .    . .. . ...   .|... |....                                               
knryldilpadnrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpl

-------------------GEQYDTDQLSGQVVDY---EWPNRAMPPLESLVELCRQLDSWlraDFKNVLVIHCKDGVHPSGI-LVVSYLLFLRALpSPS
                   .|.|| . ...... |    .|    |.|| . |... ....   | ......|||.|.. .|  .|. ||. |. . |. 
lildgngneptaadlellkeelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sle

SALRLFTARRL
 ||. . ..| 
ealedvrlkRp
0048076 (Phosphotyrosine protein) phosphatases II 442-554 1.8e-12 42.6 In-house 31-137 (145) alignment 
Range on Protein: 442-554
Range on HMM: 31-137/145.0
YLVFNLSGEQYDTDQLSGQVVDYEWPNRAMPPL-ESLVELCRQLDSWLRADfkNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRlpegQ
..|.||. |...  .|  |.. . || .  |.| | | |........|...  .. ..||. ||. .| ||. ||..|.   |. .||.|. ..|     
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllg.vsleealelvrsqr....p

GMDISPSDRRYLNY
|. ..|. .|.| .
gavpnpgqlrflye
0044763 (Phosphotyrosine protein) phosphatases II 398-554 2e-12 42.6 In-house 19-165 (178) alignment 
Range on Protein: 398-554
Range on HMM: 19-165/178.0
KSTDITYVTSRILVMSYPFeeggvgrpnvlKEVSAYLEGTHPSqyLVFNLSG---------EQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSW
  ....... .....|.|             .  ..|   . .  .. ||..          .|. .. . |.. . .|    |. || . |... ....
dyinaseilpglylgslpp...........addlellkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieea

LR-ADfKNVLViHCKDGVHPSGILVVSYLLFLRALpSPSSALRLFTARRlpegQgMDISPSDRRYLNY
|   . ..||| ||. ||. || ||. ||.  . | |. .|..|. .||      . ..|...|.| .
ldekg.gpvlV.HCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR....p.ivpnpgqlrqLye
0051082 (Phosphotyrosine protein) phosphatases II 400-542 3.6e-12 41.6 In-house 6-134 (151) alignment 
Range on Protein: 400-542
Range on HMM: 6-134/151.0
TDITYVTSRILVMSYPFEeggvgrpnvlkEVSAYLegTHPSQYLVFNLSGEQ---YDTDQLSG---QVVDYEWPNRAMPPLESLVELCRQLDSWLRADFK
....|||........| .           .. ..|   .   . ..|| .|.   |... |     .|... ...   |.|. . . .... ..|... .
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVLVIHCKDGVHPSGILVVSYLLFLRalPSPSSALRLFTARRLpegqgM
.....||. |.. .|.||. ||. |.   |. .||. . ..|      .
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp.....g
0043336 (Phosphotyrosine protein) phosphatases II 404-556 1e-11 40.3 In-house 75-273 (278) alignment 
Range on Protein: 404-556
Range on HMM: 75-273/278.0
YV----------TSRILVMSYPFEEggvgrpnvlkevS----------------------------------------------AYLEGTHPSQYLVFNL
|.          . .......| .|            .                                               .|. .| . | |..|
YinAsyvdgynvprkfiatqgPlpe............tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtl

SGE--QYDTDQLSGQVVDYEWPNRAMP-PLESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFTARRlpegQ
  .  ...  .   ..  . ||    | .|..|..........|. | ......||..||. .| ... |||.     .  ... .|.. .  .|     
evtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR....p

GMDISPSDRRYLNYMM
|.  .||  |.| ...
gavqtpsqyrflyeal
0048179 (Phosphotyrosine protein) phosphatases II 442-549 1.1e-11 40.2 In-house 31-134 (144) alignment 
Range on Protein: 442-549
Range on HMM: 31-134/144.0
YLVFNLSGEQYDTDQLSG--QVVDYEWPNRAMPPL-ESLVELCRQLDSWLRADfkNVLVIHCKDGVHPSGILVVSYLLFLRAlPSPSSALRLFTARRLpe
..|.||. | . ..      |.. . ||..  |.| | | |... ....|. .  .. ..||. ||. .| ||. ||....   |. .||.|. .||   
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkklg.lsleealalvrsrrp..

gqGMDISPSDR
  |. ..|. .
..gavpnpgql
0045098 (Phosphotyrosine protein) phosphatases II 435-535 3.9e-11 38.3 In-house 132-250 (278) alignment 
Range on Protein: 435-535
Range on HMM: 132-250/278.0
EGTHPSQYLVFNLSGEQYDTDQLSGQVVDY-EWPNRAMPPLE---SLVELCRQLDSWLR------------ADFKNVLVIHCKDGVHPSGILVVSYLLFL
.  .   .|| ||. |..|  ..  ....|  ||    |.|.   |. ||.......|.             | ... ..||. ||. .| ||. ||.  
ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmle

R--ALPSPSSALRLFTARR
.     .. .|.. .  .|
lleggvdlleavkelrsqR
0049260 (Phosphotyrosine protein) phosphatases II 438-553 4.9e-11 38.0 In-house 33-143 (152) alignment 
Range on Protein: 438-553
Range on HMM: 33-143/152.0
HPSQYLVFNLSGEQ-YDTDQLSGQVVDYEWPNRAMPPLESLVELCRQLDSWLRADFKNVLVIHCKDGVHPSGILVVSYLLFlrALPSPSSALRLFTARRl
. . ... .   |  ..      |.  . ||    |.|. |.. . ... .|. | ... ..||. ||  .| ||. ||.      |.  |..|. ..| 
gittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..lgvsleeavalvrekR.

pegQGMDISPSDRRYLN
    |. ..|. .|.| 
...pgavpnpgqlrfly
0045450 (Phosphotyrosine protein) phosphatases II 433-555 6.8e-11 37.9 In-house 169-299 (307) alignment 
Range on Protein: 433-555
Range on HMM: 169-299/307.0
YLEGTHPSQYLVFNLSGEQYDTDQLSGQVVDYEW---PNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLRAL------
.|. .| . | |..|  . .| .. | .|  . .   |.   || .|.|..........|...  ... ..||..||  .| ... ||.  .        
llseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtll

-PSPSSALRLFTARRlpegQGMDISPSDRRYLNYM
 ... .|..|. ..|     |.  .|.  |.| ..
dvdlleavkllreqR....pgavqnpeqyrflyea
0046845 (Phosphotyrosine protein) phosphatases II 406-556 1.5e-10 36.4 In-house 76-270 (284) alignment 
Range on Protein: 406-556
Range on HMM: 76-270/284.0
TSRILVMSYPFEE-------------------------GG-----VGRPNVlKEVSAY-------LEGTHPSQYLVFNLSGEQYDTDQLSGQVVDY---E
. .......| ..                          |       .|.  .||  |       |. .. . | |..|. . ..... | .|  .   .
kkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhyts

WPNRAMPP-LESLVELCRQLDSWLRA-DFKNVLVIHCKDGVHPSGILVVSYLLFLRA-------LPSPSSALRLFTARRlpegQGMDISPSDRRYLNYMM
||..  || .|.|.|..|.....|.. . ... |.||..||  .| ... .||. .         ... .|.. .  .|     ||  ...  |.. ...
wpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR....pgmvqtleqyrfvyeal
0040439 (Phosphotyrosine protein) phosphatases II 437-553 6.8e-10 34.4 In-house 119-239 (249) alignment 
Range on Protein: 437-553
Range on HMM: 119-239/249.0
THPSQYLVFNLSGEQ-YDTDQLSGQVVDY-EWPNRAMP-PLESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSAL
.. . | |..|  .  || . .  ... |  ||    |  .|.|..........|...  ......||..||. .|.... ||..     .   .. .|.
evkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeav

RLFTARRlpegQGMDISPSDRRYLN
.|.  .|     |.  .|.  |.| 
kllrsqR....pgavqnpeqyrfly
0040438 (Phosphotyrosine protein) phosphatases II 443-556 1.3e-09 33.3 In-house 159-272 (317) alignment 
Range on Protein: 443-556
Range on HMM: 159-272/317.0
LVFNLSGEQYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLL-----FLRaLPSPSSALRLFTARRl
... ... . ..     .     ||    || ...|..........|. | ......||..||. .| ... ||.       .  ... .|.. . ..| 
rtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqR.

pegQGMDISPSDRRYLNYMM
    |.  .|.  |.| ...
...pgavqtpeqyrflydal
0047943 (Phosphotyrosine protein) phosphatases II 441-556 2.2e-09 32.6 In-house 149-268 (273) alignment 
Range on Protein: 441-556
Range on HMM: 149-268/273.0
QYLVFNLSGE--QYDTDQLSGQVVDYEWPNRAMP-PLESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLF----LRALPSPSSALRLFT
 | |..|  .  ...      ..  ..||.   |  ||||.|........|.|.  ... |.||..||  .| ... .||.     .  ... .|..|. 
dytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllr

ARRlpegQGMDISPSDRRYLNYMM
 .|     || ..|. .|.| ...
sqR....pgmvqtpeqyrflyeal
0051299 (Phosphotyrosine protein) phosphatases II 439-531 6.8e-09 31.1 In-house 159-261 (288) alignment 
Range on Protein: 439-531
Range on HMM: 159-261/288.0
PSQYLVFNLSGE------QYDTDQLSGQVVDYEWPNRAMPP-LESLVELCRQLDSWLRaDFKNVLVIHCKDGVHPSGILVVSYLLFL----RALPSPSSA
 . | |..|  .      . .. .   .   . ||.  .|. .|.|....|.....|. . ... |.||..||  .| ... .||.     .  ... .|
lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvlea

LRLF
.. .
vkrl
DnaJ DnaJ domain 1234-1281 1.6e-08 23.4 Pfam-A 13-59 (64) alignment 
Range on Protein: 1234-1281
Range on HMM: 13-59/64.0
EADQVSKYFRKACLSVHPDKVDESNaNLARAIFDELNDAYELFEQSGA
 .... | .|| .| .|||| ....   |   | |.|.|||  ...  
sdeeIkkaYrklalkyHPDknkdde.eeaeekfkeineAyevLsdpek
0036941 (Phosphotyrosine protein) phosphatases II 460-552 9.1e-08 27.2 In-house 172-269 (297) alignment 
Range on Protein: 460-552
Range on HMM: 172-269/297.0
QVVDYEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLRAL-------PSPSSALRLFTARRlpegQGMDISPSDRR
.     ||   .|.  .||..........|..   ... ..||..||. || ... .|.. .         ... .|.. .  .|     |.  ...  |
hfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqR....pgavqtleqyr

YL
.|
fl
PTPc_DSPc_SM00012 464-519 2.4e-06 23.1 In-house 8-65 (105) alignment 
Range on Protein: 464-519
Range on HMM: 8-65/105.0
YEWPNRAMPP-LESLVELCRQLDSWLRAD-FKNVLVIHCKDGVHPSGILVVSYLLFLR
..||.  .|   .|..||.|..... ..   .. .|.||..||  .|..|. ..|  .
tgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq
0050432 (Phosphotyrosine protein) phosphatases II 464-517 2.4e-06 22.6 In-house 205-256 (308) alignment 
Range on Protein: 464-517
Range on HMM: 205-256/308.0
YEWPNRAMPP-LESLVELCRQLDSWLradFKNVLVIHCKDGVHPSGILVVSYLLF
  ||.   || .|.|..........|    ... |.||..||  .| ... .||.
tnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdlll