Gene Tensin in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Tensin
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP042_AA protein Get Run
AqueP042_AA_136-322 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Tensin_pd Subfamily Tensin 150-329 1.6e-95 311.0 In-house 1-180 (189) alignment 
Range on Protein: 150-329
Range on HMM: 1-180/189.0
RNRYTDDGFDLDLSYITDRIIAMSFPGSGVESAYRNNLKDVAKMLKTQHQDNYMVFNLSERSYDISKFNNQVLDFGWPDHLAPSLERLSIVCKSMKSWLD
..||... .||||.|||.||||.|||..|.|..||.|||||||.||..|.|.|.||||||..|||||.|..||||||||.||||||.|...|||..|||.
kvryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

SDPNHVVVVHCKGGKGRTGCVIASFMNYSQICQSASAALDHFAMKRFYDDKLQGVTQPSQRRYVHYFEDLLVGKLKLDAR
.||..||||||||||||.|.|....|.||.|..||.||||.||||||.||||.|.|||||||||.||..||.||.||...
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnss
subfamily_PTEN_pd Subfamily PTEN 142-322 4.6e-68 223.8 In-house 2-181 (184) alignment 
Range on Protein: 142-322
Range on HMM: 2-181/184.0
VKRQVAKGRNRYTDDGFDLDLSYITDRIIAMSFPGSGVESAYRNNLKDVAKMLKTQHQDNYMVFNL-SERSYDISKFNNQVLDFGWPDHLAPSLERLSIV
....|.| ..|...||.||||||||..||||..|  ..|..|||.|.|| |.|...|.|.|...|| |||.|| .||...|  ..  || .|.|| |. .
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

CKSMKSWLDSDPNHVVVVHCKGGKGRTGCVIASFMNYSQICQSASAALDHFAMKRFYDDklQGVTQPSQRRYVHYFEDLLVG
......||..|...||||||| |||||| .|.... .|.....|. ||..|| .|. ..  .||| |||||||.|.|.||  
vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk..kgvtiPsqrRYveYyekllee
subfamily_VSP_pd Subfamily VSP 136-320 2.4e-64 211.2 In-house 10-198 (212) alignment 
Range on Protein: 136-320
Range on HMM: 10-198/212.0
KNITEIVKRQVAKGRNRYTDDGFDLDLSYITDRIIAMSFPGSGVESAYRNNLKDVAKMLKTQHQDNYMVFNL-SERSYDISKFNNQVLDFGWPDHLAPSL
.... ...| |.. . ||| |||||||.|.|.|||||||| || .| ||| ...||..|.|.|.|.| |.|| |||.|| . |||.|      ||  |.|
rklekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkl

ERLSIVCKSMKSWLDSDPNHVVVVHCKGGKGRTGCVIASFMNYSQICQSASAALDHFAMKRF---YDDKLQGVTQPSQRRYVHYFEDLL
|.|  ..| .| ||. |...|...|||||||||| .. ... .|.|...|  .||.|. .|      .| |||  |||.|||.|.|.. 
eellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvk
subfamily_Auxilin_pd Subfamily Auxilin 159-320 3.4e-53 172.7 In-house 8-164 (166) alignment 
Range on Protein: 159-320
Range on HMM: 8-164/166.0
DLDLSYITDRIIAMSFPGSGVESAYRNNLKDVAKMLKTQHQDNYMVFNLSERSYDISKFNNQVLDFGWPDHLAPSLERLSIVCKSMKSWLDSDPNHVVVV
|||.|||| ||| ||||  ||||.|.||..||...| ..|...|.|.|||.|.|. .|....|.. ||| . ||.|| |  ||. . |||  ||..||||
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvv

HCKGGKGRTGCVIASFMNYSQICQSASAALDHFAMKRFYDDklqgvTQPSQRRYVHYFEDLL
||| |.  .. ...... . .. .....|.. |..||   .      .||..||..|. |||
hckDGraasavlvsallvfcrllsepesavrlfsvkrlpig.....lspsekryleyladll
PTEN_1 150-322 7.4e-47 154.7 In-house 10-194 (196) alignment 
Range on Protein: 150-322
Range on HMM: 10-194/196.0
RNRYTDDGFDLDLSYITDRIIAMS-FPGSG-----VESAYRNNLKDVAKMLKTQHQDN-YMVFNLSE------RSYDISK-FNNQVL--DFGWPDHLAPS
 ... .....|||.|||.|||||. .|. .      |. ||..|||||..|.....|. ..|.||||      |||| .. |...|   .|...|| |||
kknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgaps

LERLSIVCKSMKSWLDSDP-NHVVVVHCKGGKGRTGCVIASFMNYSQIcQSASAALDHFAMKRFYDDKLqgvtQPSQRRYVHYFEDLLVG
|..|  .|||...|| ||| ..||.||||.|.||.|.|.|... |..   .|  ||.... ||    .     .|||.|...||..|| .
lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn....spsqerlleyfaellae
0036282 (Phosphotyrosine protein) phosphatases II 158-321 1.2e-41 137.7 In-house 8-170 (174) alignment 
Range on Protein: 158-321
Range on HMM: 8-170/174.0
FDLDLSYITDRIIAMSFPGSGVESAYRNNLKDVAKMLKTQHQDNYMVFNLS-ERSYDISKFNNQVLDFGWPDHLAPSLERLSIVCKSMKSWLDSDPNHVV
..|||||||.|.||...| . .|  .......|  .|. .. ..|...|.  |...| .... |.|...|||| .|.|. |  ..| ....| .||...|
spldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

VVHCKGGKGRTGCVIASFMNYSQICQSASAALDHFAMKRFYddKLQGVTQPSQRRYVHYFEDLLV
.|||..|.||||...| .. . ....|.  |||.....|..  . ..|. |||.|...|||.|| 
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq..rpgmvqtpsQyrflyyfeklls
0038934 (Phosphotyrosine protein) phosphatases II 164-317 6.2e-36 119.2 In-house 15-193 (194) alignment 
Range on Protein: 164-317
Range on HMM: 15-193/194.0
YITDRIIAMSFPGSG-----VESAYRNNLKDVAKMLKTQHQDNYMVFNLS--ERSYDISKFNN---QVLDFGWPDH-LAPSLERLSIVCKSMKSWLDSDP
.||.|.||...| ||     .|. ||....|. ..||........| .|.  || || ..| .   ..|.. .||.  .|||| |   .. .. .|. ||
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

NHVVVVHCKGGKGRTGCVIASFMNYSQICqSASAALDHFAMKR---------------FYDDKLQGVTQPSQRRYVHYFE
..||.||||.|.||||...|... |.. . || .|...|..||               .|..  ..|..|.........|
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekRpgaipnqdyleallkrykelrkavlapekpelllede
0037934 (Phosphotyrosine protein) phosphatases II 143-319 8e-35 115.9 In-house 6-240 (243) alignment 
Range on Protein: 143-319
Range on HMM: 6-240/243.0
KRQVAKGRNRYT--------------DDGFDLDLSYITDRIIAMSFPGSGVESA---------YRNNLKDVA----------------------------
.... . .|||.              .| ....|.|.|.|.||...| ..             .... . .                             
llpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftv

KMLKTQHQDNYMVFNLSERS---YDISKFNNQVLDFGWPDHLAPS-LERLSIVCKSMKSWLDS-------DPNHVVVVHCKGGKGRTGCVIASFMNYSQI
..|...| |.|.|..|. .    .| .... ... ..|||| .|.  | |   .. .......       |....|.|||..|.||||..|| .. ....
tllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll

CQSASAALDHFAMKRFYddklQGVTQPSQRRYVHYFEDL
. ..  |.... ..|..     .|. |||.|......  
gvdleeavkllreqRpg....kavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 137-321 2.3e-34 114.7 In-house 47-289 (297) alignment 
Range on Protein: 137-321
Range on HMM: 47-289/297.0
NiTEIVKRQVAKGRNRYT--------------DDGFDLDLSYI-----------TDRIIAMSFPGSG-----VESAYRNNLKDVA---------------
. ..| .... | .|||.               ||.|||..||           |...||...| ..      .  .... . .                
d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqy

-------------KMLKTQHQDNYMVFNLSERSYDISKFNNQVLDFGWPDHLAP-SLERLSIVCKSMKSWLDSD-PNHVVVVHCKGGKGRTGCVIASFMN
             ..||..| |.|.|..|. . .. |.. .... .||||| .| ||| |  ... ....| .. ....|.|||..|.||||..|| .. 
wpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylm

Y----SQICQSASAALDHFAMKRfyddkLQGVTQPSQRRYVHYFEDLLV
.    .  . ..  |.... ..|      ..|. ||| |......  |.
leqlekeggvdvleavkelreqR.....pgavqtpsqyrflydallell
0041856 (Phosphotyrosine protein) phosphatases II 149-318 2.2e-33 110.8 In-house 3-168 (182) alignment 
Range on Protein: 149-318
Range on HMM: 3-168/182.0
GRNRYTD---DGFDLDLSYITDRIIAMSFPGSGVESAYRNNLKDVAKMLKTQHQDNY-MVFNLSERSYDISKFNN---QVLDFGWPDHLAPSlerLSIVC
 .|||.|     ...||.||.......|.|..  . .... |..||..|.. .. .. .. ||.|. |. .....   |.|...|||| .|.   |....
dknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldell

KSMKSWLDsdPNHVVVVHCKGGKGRTGCVIASFMNYSQiCQSASAALDHFAMKRFYddklqGVTQPSQRRYVHYFED
. .. .|.  ....|.|||..|.||||...| .. ...   |.  |.... ..|.      .|..|.| ....... 
dfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpg.....mvitpnqyfflqlall
0046846 (Phosphotyrosine protein) phosphatases II 152-322 2.6e-33 110.6 In-house 2-174 (176) alignment 
Range on Protein: 152-322
Range on HMM: 2-174/176.0
RYTDDGFDLDLSYITDRIIAMSFPGSGVESAYRNNLKDVAkMLKTQhqDNYMVFNLSERS-----------YDISKFNNQVLDFGWPDHLAPSLERLSIV
|.. .|.||||.||....|..|.|. . .. .|.  .... ||| .  . ..|.|| |.             .. |.. |.| ..|||| .|.|| |  .
rlrllgldldldyinanlilgsrpiatqgplprtladfle.mlkel..gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

CKSMKSWLDSDpnHVVVVHCKGGKGRTGCVIASFMNYSQICQSASAALDHFAMKRFYddklQGVTQPSQRRYVHYFEDLLVG
.. ....|...  ..|.|||..|.||||...| .. ... . |.  ||... ..|..    . |. |.|.|....|| || .
lefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl....gavqtpeQyrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 154-320 4e-31 103.4 In-house 7-160 (172) alignment 
Range on Protein: 154-320
Range on HMM: 7-160/172.0
TDDGFDLDLSYITDRIIAMSFPgsgvesaYRNNLKDVAKMLKTQHQDNymVFNLSER---SYDISKFNNQVLDFGWPDHLAPSLERLSIVCKSMKSWLDS
  . ..|||.||.||.||. .|       .||.| |. .|||... .   ..|| |.    .. .... |.| ..|||| .|.|| |  ... ....|  
yinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellal

DPNHVVVVHCKGGKGRTGCVIASFMNYsqICQSASAALDHFAMKRfyddkLQGVTQPSQRRYVHYFEDLL
.|...|.|||..|.||||...| .. .   . |.  |.... .||      ..|. |||.|...|||.||
spggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR.....pgavqnpsqyrflyyfekll
0043336 (Phosphotyrosine protein) phosphatases II 139-317 3.9e-30 100.7 In-house 37-273 (278) alignment 
Range on Protein: 139-317
Range on HMM: 37-273/278.0
TEIVKRQVAKGRNRY-------------TDDGFDLDLSYI----------TDRIIAMSFPGSGVESAYRNNLKD--------------------------
..| ...  | .|||             ...|.|||..||          ....||...| .. .  ... ...                          
ysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpg

--------VAKMLKTQHQDNYMVFNLSER--SYDISKFNNQVLDFGWPDHLAP-SLERLSIVCKSMKSWLDsDPNHVVVVHCKGGKGRTGCVIASFMNY-
        . ..||..|.|.|.|..|      .. |.. ...  .||||| .| ||. |   .| ....|. |.|..|.|||..|.||||..|| .. . 
gsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllle

---SQICQSASAALDHFAMKRfyddkLQGVTQPSQRRYVHYFE
   .  . ..  |.... ..|      . |. ||| |......
qlekeggvdleeavkelreqR.....pgavqtpsqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 142-317 1.8e-29 98.3 In-house 4-239 (245) alignment 
Range on Protein: 142-317
Range on HMM: 4-239/245.0
VKRQVAKGRNRY-------------TDDGFDLDLSYI----------TDRIIAMSFPGSGVES-----AYRNNLKDVA----------------------
 .... | .|||             ..||.|||..||          |...||...| ..         ...... .                       
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

--------KMLKTQHQDNYMVFNLSER--SYDISKFNNQVLDFGWPDHLAPS-LERLSIVCKSMKSWLDSDPNHVVVVHCKGGKGRTGCVIASFMNY---
        ..|...| |.|.|..|.     .| |....... ..|||| .|. || |  ... ....| .|.|..|.|||..|.||||..|| .. .   
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

-SQICQSASAALDHFAMKRfyddkLQGVTQPSQRRYVHYFE
 .  . |.  |.... ..|      . |. ||| |......
ekelgvsleeavkelrsqR.....pgavqtpsqyrflyeal
0049260 (Phosphotyrosine protein) phosphatases II 171-320 2.5e-26 87.6 In-house 6-149 (152) alignment 
Range on Protein: 171-320
Range on HMM: 6-149/152.0
AMSFPGSGVESAYRNNLKDVAKMLKTQHQDNYMVF-NLSERSYDISKFNNQVLDFGWPDHLAPSLERLSIVCKSMKSWLDSDPNHVVVVHCKGGKGRTGC
||.|.  . .  ..|.|.|. .|||... . . .  .|.|. ..  ..  |.| . |||| .|.|. | . .  .  .|  |....|.|||..|.||||.
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

VIASFMNYsqICQSASAALDHFAMKRfyddkLQGVTQPSQRRYVHYFEDLL
..| .. .     |.  |.... .||      ..|. |.|.|....||.||
lvaaylml..lgvsleeavalvrekR.....pgavpnpgqlrflyefekll
0040438 (Phosphotyrosine protein) phosphatases II 137-321 1.3e-25 85.8 In-house 33-276 (317) alignment 
Range on Protein: 137-321
Range on HMM: 33-276/317.0
NITEIVKRQVAKGRNRY-------------TDDGFDLDLSYI----------TDRIIAMSFPGSG-----VESAYRNNLKDVAKMLKT------------
. ... .... |..|||             ...|.|||..||          ....||...| ..      .  ...... .  . ..            
dtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYw

------------------QHQDNYMVFNLSER--SYDISKFNNQVLDFGWPDHLAP-SLERLSIVCKSMKSWLDsDPNHVVVVHCKGGKGRTGCVIASFM
                  .. ... ...|       . | ....    ||||| .| |.. |   .. ....|. ||...|.|||..|.||||..|| ..
plgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaayl

N-----YSQiCQSASAALDHFAMKRfyddkLQGVTQPSQRRYVHYFEDLLV
      . . . ..  |.... ..|      ..|. |.| |......  ..
mleqlekeg.gvdveeavkelreqR.....pgavqtpeqyrflydalleyl
0045450 (Phosphotyrosine protein) phosphatases II 140-317 3.2e-25 84.9 In-house 48-300 (307) alignment 
Range on Protein: 140-317
Range on HMM: 48-300/307.0
EIVKRQVAKGRNRYTD-------------------------------------DGFDLDLSYI----------------------------------TDR
.| .... | .|||.|                                     ||.||.. .|                                  ...
siallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgre

IIAMSFPGSGVESAYRNnlkDVAKMLKTQHQDNYMVFNLSERSYDISKFNNQVLDFGW---PDHLAP-SLERLSIVCKSMKSWLDSD-PNHVVVVHCKGG
..|. .| .| |  |.|   .. ..|...|.|.| |..|    .| ...  .|  | .   ||| .| |.| |   .. ....|... ....|.|||..|
kcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaG

KGRTGCVIASFMNYSQIC-------QSASAALDHFAMKRfyddkLQGVTQPSQRRYVHYFE
.||||..|| .. ..|.         ..  |.... ..|      ..|. |.| |......
vgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR.....pgavqnpeqyrflyeal
0046845 (Phosphotyrosine protein) phosphatases II 144-316 5e-25 83.9 In-house 25-269 (284) alignment 
Range on Protein: 144-316
Range on HMM: 25-269/284.0
RQVAKGRNRYTD-----------------------------DGFDLDLSYITDRIIAMSFPGSG-----------------------------VESAYRN
..  . .|||.|                             ||.||||.||. ..||...| ..                               . |..
lpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwp

NLKDVAKM-------LKTQHQDNYMVFNLSERS---YDISKFNNQVLDFGWPDHLAP-SLERLSIVCKSMKSWLDS-DPNHVVVVHCKGGKGRTGCVIAS
. ..| ..       |.....|.|.|..|. .     . |.. ..   ..|||| .| |.| |   .. ....|.. ......||||..|.||||..|| 
legevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfial

FMNYSQI-------CQSASAALDHFAMKRfyddkLQGVTQPSQRRYVHYF
 . ..|.       . ..  |. .. ..|      . |....| |.|...
dllleqlekeglllgvdvleavkrlreqR.....pgmvqtleqyrfvyea
0040439 (Phosphotyrosine protein) phosphatases II 143-318 2.4e-24 81.8 In-house 7-243 (249) alignment 
Range on Protein: 143-318
Range on HMM: 7-243/249.0
KRQVAKGRNRYT---------------DDGFD--------LDLSYITDRIIAMSFPGSGVESAYRNNLKD------------------------------
.... | .|||.               ...|.        .|..||..|.||...| ..  ..... |..                              
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsl

-----VAKMLKTQHQDNYMVFNLSERS-YDISKFNNQVLDF-GWPDHLAP-SLERLSIVCKSMKSWLDSD-PNHVVVVHCKGGKGRTGCVIASFMNY---
     . ..|.... |.|.|..|     || ...  ... . .|||| .| |.| |   .. ....|... ....|.|||..|.||||..|| .. .   
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql

-SQICQSASAALDHFAMKRfyddkLQGVTQPSQRRYVHYFED
    . ..  |.... ..|      ..|. |.| |...... 
ekelgvdleeavkllrsqR.....pgavqnpeqyrflyeall
0051082 (Phosphotyrosine protein) phosphatases II 160-317 4.9e-24 80.1 In-house 6-148 (151) alignment 
Range on Protein: 160-317
Range on HMM: 6-148/151.0
LDLSYITDRIIAMSFPgsgveSAyrnnlkDVAKMLktQHQDNYMVFNLSERS---YDISKFNN---QVLDFGWPDHLAPSLERLSIVCKSMKSWLDSDPN
...||.|........|     .|      |. ..|  .... ....|| .     |. . ...   .||.. ..|. .|.|. .   .... ..|....|
infsyvtgglyrsggp.....la......dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

HVVVVHCKGGKGRTGCVIASFMNYSQicQSASAALDHFAMKRFyddklqGVTQPSQRRYVHYFE
..|.|||..||||||...| .. . .   |. .||... .||.      ||.||.| .....|.
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp......gvvqpnqqflfqlfa
0048076 (Phosphotyrosine protein) phosphatases II 175-320 6e-24 79.8 In-house 4-142 (145) alignment 
Range on Protein: 175-320
Range on HMM: 4-142/145.0
PGSGVESAYRNNLKDVAKMLKTQHQDNYMVFNLSERSYDISKFNNQVLDFGWPDHLAPSL-ERLSIVCKSMKSWLDSDpnHVVVVHCKGGKGRTGCVIAS
|   ... |...| .. ..   .. . ..|.||.   .. .... |.| ..|||| .|.| | |  ... ....|...  ..|.|||. |.||||...| 
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaa

FMNYSQIcQSASAALDHFAMKRFYddklqGVTQPSQRRYVHYFEDLL
.. ...   |.  ||... ..|..     .|. |.|.|....||  |
ylmlllg.vsleealelvrsqrpg.....avpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 174-320 4.3e-23 77.1 In-house 3-144 (144) alignment 
Range on Protein: 174-320
Range on HMM: 3-144/144.0
FPGSGVESAYRNNLKDVAKMLKTQHQDNYMVFNLSERSYDISKFNN--QVLDFGWPDHLAPSL-ERLSIVCKSMKSWLDsdPNHVVVVHCKGGKGRTGCV
.|   ... |...| .. ..   .... ..|.||.|  .  .  ..  |.| ..|||| .|.| | |  ... ....|.  ....|.|||..|.||||..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtl

IASFMNYSQIcQSASAALDHFAMKRFyddklQGVTQPSQRRYVHYFEDLL
.| .. . .   |.  ||... ..|.     ..|. |.|.|.....|.||
vaaylmkklg.lsleealalvrsrrp.....gavpnpgqlrfLleyekll
0044763 (Phosphotyrosine protein) phosphatases II 153-322 7.1e-23 76.6 In-house 14-172 (178) alignment 
Range on Protein: 153-322
Range on HMM: 14-172/178.0
YTDDGFDLDLSYITDRIIAMSFPGsgvesayrnnlKDVAKMLKTQHQDnyMVFNLSE---------RSYDISKFNNQVLDFGWPDHLAPS-LERLSIVCK
..  .. ...|.|.......|.|             |  ..|| .. .  .. ||.|           |. .... |.| ...||| .|. || .  ...
glersdyinaseilpglylgslpp...........addlellkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefve

SMKSWLDsDPNHVVVVHCKGGKGRTGCVIASFMNYSQiCQSASAALDHFAMKRfyddkLqGVTQPSQRRYVHYFEDLLVG
 ....|| .....|.|||. |.||.|...| .. ...   |. .|.... ..|       .|. |.|.|....||  | .
fieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.glsleeaielvrerR.....p.ivpnpgqlrqLyefelrllk
0045098 (Phosphotyrosine protein) phosphatases II 157-321 1.4e-21 72.6 In-house 4-272 (278) alignment 
Range on Protein: 157-321
Range on HMM: 4-272/278.0
GFDLDLSYITDRIIAMSFPGSGVESAYRNNLK--------------------------------------------------------------------
...|||............|..  .. |..||.                                                                    
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

-----------------------DVAKMlKTQHQDNYMVFNLSERSYDISKFNNQVLDF-GWPDHLAPSLE---RLSIVCKSMKSWLD------------
                       ..  . .. .   ..| ||. . .|. ... ..|.. .|||| .|||.    .  ... ....|.            
ekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

SDPNHVVVVHCKGGKGRTGCVIASFMNYSQI--CQSASAALDHFAMKRfyddkLQ-GVTQPSQRRYVHYFEDLLV
 |....|.|||. |.||||...| .. ....    ..  |.... ..|      .  |. ..| |....|. .|.
ldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR.....pglavqnleqyrflyefllell
0049772 (Phosphotyrosine protein) phosphatases II 165-315 5.9e-20 67.7 In-house 124-274 (314) alignment 
Range on Protein: 165-315
Range on HMM: 124-274/314.0
ITD---------------------RIIAMSFPgSGVESAYRNNLKdvakmlktqhqdnymvfnlsERSYDISKFNNQVLDF---GWPDHLAPSLERLSIV
|                        .|.. .. .    |.  .||                    |. || ..| .... .    .||. ||.|| .  .
ivmsrdevladelsrLdaAlgKtpllildgng.neptaadlellk....................eelydpelferlgikylripvpDgsaplledfdef

CKSMKSWldsDPNHVVVVHCKGGKGRTG--CVIASFMNYSQIcqSASAALDHFAMKRFYDDKLQGVTQPSQRRYVHY
.. ....   |....|.||||.||||||  .|.|  | . ..  |.  ||... .||..  .   . |. |  ....
lefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv..sleealedvrlkRpinpnpgfieqleqyefile
0047943 (Phosphotyrosine protein) phosphatases II 191-315 1.5e-18 62.7 In-house 139-266 (273) alignment 
Range on Protein: 191-315
Range on HMM: 139-266/273.0
AKMLKTQHQDNYMVFNLSERS--YDISKFNNQVLDFGWPDHLAP-SLERLSIVCKSMKSWLDSD-PNHVVVVHCKGGKGRTGCVIASFMNYSQ----ICQ
 ..|.... |.|.|..|  ..  .. |.. .... .||||| .| ||| |   .. ....| ..  |..|||||..|.||||..|| .. ..|     . 
vtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggv

SASAALDHFAMKRFYddklqGVTQPSQRRYVHY
..  |. .. ..|..     .|. |.|.|....
dvleavkllrsqRpg.....mvqtpeqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 192-315 3e-16 55.2 In-house 152-280 (288) alignment 
Range on Protein: 192-315
Range on HMM: 152-280/288.0
KMLKTQHQDNYMVFNLSER------SYDISKFNNQVLDFGWPDHLAPS-LERLSIVCKSMKSWLDsDPNHVVVVHCKGGKGRTGCVIASFMNYSQICQSA
..|.....|.|.|..|  .        . |.. ..   ..|||| .|. .| |   .. ....|  .....|||||. |.||||..|| .. ..|. .  
tllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeg

SAALDHfAMKRFYDDKLQGVTQPSQRRYVHY
   . . |.||.   . . |. |.| |.|..
gvdvle.avkrlreqRpgmvqtpeqyrfvye
0036941 (Phosphotyrosine protein) phosphatases II 192-321 1.2e-14 49.7 In-house 140-277 (297) alignment 
Range on Protein: 192-321
Range on HMM: 140-277/297.0
KMLKTQH--QDNYMVFNLSERS--YDISKFNNQVLDFGWPDHLAPS-LERLSIVCKSMKSWLDSD-PNHVVVVHCKGGKGRTGCVIASFMNYSQIC----
..|....   |.| ...|      .. |.. ..   .||||| .|.  . |   .. ....|.   ....|.|||..|.||.|..|| .. ..|..    
tllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklk

---QSASAALDHFAMKRFYddklqGVTQPSQRRYVHYFEDLLV
    .   |. .. ..|.       |....| |......  |.
eggvdileavkklReqRpg.....avqtleqyrflyeallell
PTB Phosphotyrosine-binding domain 1095-1210 6.1e-14 41.0 Pfam-A 19-125 (131) alignment 
Range on Protein: 1095-1210
Range on HMM: 19-125/131.0
STITE---AAKQLKALDLPTSTVVNFKASMSGVTITDKANGLLSkRNYPINSILHCGLDPNDTRWDLshleesvsiknkpCFGIVHKMQDSPGYMCLLFA
... .     |.|.| . .... | .| |  |||.|| .      ..||.||. .| ..... |..               ...| . ..|      ||.
eavedaiaklklldakgkvwaqevllkVsaqgvtLtDnerKeel.esyplnsvkkckavleerryes.............llalvarepesskenvhlFq

--EVDAHQPVSNVVAYVKRLM
  |..| |. ....  .....
cdeleaeqiaediekalskvk
0050432 (Phosphotyrosine protein) phosphatases II 192-314 7.7e-13 43.9 In-house 171-292 (308) alignment 
Range on Protein: 192-314
Range on HMM: 171-292/308.0
KMLKTQHQDNYMVFNLSERS--YDISKFNNQVLDFGWPDHLAPS-LERLSIVCKSMKSWLdsdPNHVVVVHCKGGKGRTGCVIASFMNYSQICQSASAAl
..|.....|.|.|..|  .   .. |.. ..    .|||| .|. .| |   .. ....|   |....||||. | ||||..||  . ..|. .      
tllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvd.

DHFAMKRFYDDKLQGVTQPSQRRYVH
   |.|..   . . |. |.| ....
vfeavkklReqRpgmvqtpeqylfly
SH2 SH2 domain 944-1038 1.5e-12 38.0 Pfam-A 1-76 (77) alignment 
Range on Protein: 944-1038
Range on HMM: 1-76/77.0
WYRPDISREDACNLVKN-MDAGSFVVRDSQTVSGGYALTIKVSRellrqrrkltddtevtddmCVTHFLIQPDPDGvKLQGWNEPAFKTLPDFIAR
||  .||||.| .| .. .  |.|.||.|..  |.|.|... ..                    |.|. || . .| |.   ..  |..|.. .  
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg...................kvkhyriqsleng.kyyitenekfsslqeLveh
subfamily_PTPDC1_pd Subfamily PTPDC1 211-295 4.1e-12 40.9 In-house 72-155 (182) alignment 
Range on Protein: 211-295
Range on HMM: 72-155/182.0
SYDISKFNNQ---VLDFGWPDHLAPSLERLSIVCKSMKSWLDSDpnhVVVVHCKGGKGRTGCVIASFMNYSQICQsASAALDHFAMKR
|||  .. .|   |  |||.|. ..||||.  . | ... |. .    | |||  |.|||| .||... |..  . |. |..    ||
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrlt.aekaiklvrskr
PTPc_DSPc_SM00012 219-309 1.1e-11 40.2 In-house 3-95 (105) alignment 
Range on Protein: 219-309
Range on HMM: 3-95/105.0
NQVLDFGWPDHLAPS-LERLSIVCKSMKSWLDSDP-NHVVVVHCKGGKGRTGCVIASFMNYSQICQSAsAALDHFAM-KRFYDDKLQGVTQPSQ
...   ||||| .|.  . .  .....|..      .. |||||. | ||||...|  . ..|....    .| | . |.. . . . |..  |
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRpgmvqteeq
0051429 (Phosphotyrosine protein) phosphatases II 193-316 2.3e-10 36.1 In-house 94-220 (272) alignment 
Range on Protein: 193-316
Range on HMM: 94-220/272.0
MLKTQHQDNYMVFNLSER---SYDISKFNNQVLDFGWPDHLAPSLErlsiVCKSMKSWLDsdpNHVVVVHCKGGKGRTGCVIASFMNYSQICQSASAA--
.|.......|.. .|  .   |.. .    . .  .|||| .|. .    ... ..  ||   .. |.|||..||.|||.|.| .. . ... .. ..  
llseellldyilrellltlllsagearevmhlhytdwpdhgvpqea....llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddY

----------LDHFAMKRfyddkLQGVTQPSQRRYVHYF
          ...   .|      . |  . |..... .
lltnlyleeaveelraqr.....pgavqteeqylflyea
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 331-379 1.4e-09 29.2 Pfam-A 81-133 (134) alignment 
Range on Protein: 331-379
Range on HMM: 81-133/134.0
HTGVDSIFRCQFHHSVVK--DERLVWTKKDLDDAFRD--KRFSDDTKVELIFE
.   . |||..|. | ..  ...|  .|..||.|  |  |.||.. ||||.||
lpkkekifrvwFNTsFieknqnvltlpkneLDkalkdkdkkfsknfkvelvfe
C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) 65-115 4.1e-09 26.1 Pfam-A 1-52 (53) alignment 
Range on Protein: 65-115
Range on HMM: 1-52/53.0
HSWAPFSLPKPHSCDACNVII---WSSSYSCQGCSMAIHPDqkCQDQVTKICRS
| |.. ....|..|. |. ..   ..  ..|. |.. .| .  |  .|.| |. 
HhwvhrnfkqptfCkhCgkflwgkgkqglkCswCqllvHkk..Cfekvpkecgc
Y_phosphatase Protein-tyrosine phosphatase 197-285 1.4e-08 29.8 Pfam-A 111-202 (235) alignment 
Range on Protein: 197-285
Range on HMM: 111-202/235.0
QHQDNYMVFNLSER--SYDI-SKFNNQVLDFGWPDHLAP-SLERLSIVCKSMKSWLdSDPNHVVVVHCKGGKGRTGCVIASFMNYSQICQSAS
.....|.. .|. .    .  ..  .|.   .|||| .| | . |  ........  .. .. |||||. | ||||...|  .  .|. .  .
edekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee
Y_phosphatase Protein-tyrosine phosphatase 197-285 1.4e-08 29.8 In-house 111-202 (235) alignment 
Range on Protein: 197-285
Range on HMM: 111-202/235.0
QHQDNYMVFNLSER--SYDI-SKFNNQVLDFGWPDHLAP-SLERLSIVCKSMKSWLdSDPNHVVVVHCKGGKGRTGCVIASFMNYSQICQSAS
.....|.. .|. .    .  ..  .|.   .|||| .| | . |  ........  .. .. |||||. | ||||...|  .  .|. .  .
edekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee
subfamily_PTPN12_pd Subfamily PTPN12 189-280 2.7e-08 28.1 In-house 143-234 (290) alignment 
Range on Protein: 189-280
Range on HMM: 143-234/290.0
DVAKMLKTQHQDNYMVFNLSERSYDISKFNNQVLDFGWPDHLAPSLE-RLSIVCKSMKSWLDsDPNHVVVVHCKGGKGRTGCVIASFMNYSQI
 | .. . . .|....  |  .  . |.  .|     ||||  || . .|  . .....  . . .. .||||  | |||| .||  . ....
evtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrell
subfamily_RNGTT_pd Subfamily RNGTT 230-296 2.8e-08 27.7 In-house 90-155 (189) alignment 
Range on Protein: 230-296
Range on HMM: 90-155/189.0
LAPSLERLSIVCKSMKSWLDSDPNHVVVVHCKGGKGRTGCVIASFMNySQICQSASAALDHFAMKRF
 ||. |. . . | .... .  |..|. |||. |  ||| .|.|..   . . |..||.. ||. | 
eaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLv.ekedwsveaavalFakaRp
subfamily_CDC14_pd Subfamily CDC14 165-277 3.2e-08 27.8 In-house 176-287 (328) alignment 
Range on Protein: 165-277
Range on HMM: 176-287/328.0
ITDRIIAMSFPGSGVESAYRNNLKDVAKMLKTQHQDN-YMVFNLSERSYDISKFNNQVLDFGWPDHLAPSLERLSIVCKSMKSwLDSDpNHVVVVHCKGG
. |...|.. | .  . . . .|.  .|.|.  .. |   |  | .. || .||... .|         |    .|| | ..  ...  .  ..|||| |
vPdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkflei.aeka.eGaiavhCkaG

KGRTGCVIASFMNY
 ||||..||... .
LGrtGtLiacylmk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 191-283 4.7e-08 27.5 In-house 136-231 (274) alignment 
Range on Protein: 191-283
Range on HMM: 136-231/274.0
AKMLKTQHQDNYMVFNLSERSYDISKFNNQVLDFGWPDHLAPS-LERLSIVCKSMKSWLDSDPNH--VVVVHCKGGKGRTGCVIASFMNYSQICQS
 |. |. ....| | .|. ..   ..     .   |||| .|   . |  ... ...  ... ..   |||||  | ||||| ||  .   |. ..
ikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlree
subfamily_PTPMT1_pd Subfamily PTPMT1 197-295 4.7e-08 27.7 In-house 52-148 (171) alignment 
Range on Protein: 197-295
Range on HMM: 52-148/171.0
QHQDNYMVFNLSERSYDISKFNNQVLDFGWPDHL-APSLERLSIVCKSMKSWLDSdpNHVVVVHCKGGKGRTGCVIASFMNYSQICQSASaALDHFAMKR
. ...| .  |.. . . .| . . | .  .|.  ||.||.|.   . ...  ..   . | ||||.|.||.. ..|... ... ... . ||.. . ||
slneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkkeklspee.AlkalkkkR
DSPc_SM00195 201-291 5.9e-08 27.7 In-house 141-233 (263) alignment 
Range on Protein: 201-291
Range on HMM: 141-233/263.0
NYMVFNLSERSYD--ISKFNNQVLDFGWPDHLAP-SLERLSIVCKSMKSWLDSDpNHVVVVHCKGGKGRTGCVIASFMNYSQICQSASAALDHF
.. . .|. .  .   ... .|.   .|||| .| | . .  . ...|.. ..  .. .||||. | ||||....  . .|....     ... 
eiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifei
PTPc_SM00194 201-291 5.9e-08 27.7 In-house 141-233 (263) alignment 
Range on Protein: 201-291
Range on HMM: 141-233/263.0
NYMVFNLSERSYD--ISKFNNQVLDFGWPDHLAP-SLERLSIVCKSMKSWLDSDpNHVVVVHCKGGKGRTGCVIASFMNYSQICQSASAALDHF
.. . .|. .  .   ... .|.   .|||| .| | . .  . ...|.. ..  .. .||||. | ||||....  . .|....     ... 
eiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifei
subfamily_PTPRK_pd Subfamily PTPRK 204-314 4.2e-07 24.1 In-house 159-270 (314) alignment 
Range on Protein: 204-314
Range on HMM: 159-270/314.0
VFNLSE--RSYDISKFNNQVLDFGWPDHLAPSLER-LSIVCKSMKSWLDSdPNHVVVVHCKGGKGRTGCVIASFMNYSQIcQSAsAALD-HFAMKRFYDD
.|....  |...  .  .|.   |||||  |  .. |  . . .|.. .   .  .||||  | ||||. ||  .    | .     .| ..|.| . . 
ifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmi.ere.gvvdvfnavktlrsr

KLQGVTQPSQRRYVH
|   |    | ....
kvnmveteeqykfiy
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 205-315 8.3e-07 23.4 In-house 166-277 (319) alignment 
Range on Protein: 205-315
Range on HMM: 166-277/319.0
FNLSERSYDISKfnNQVLD---FGWPDHLAPSLERLSI-VCKSMKSWLDSDPNHVVVVHCKGGKGRTGCVIASFMNYSQICQsaSAALDHFAMKR-FYDD
..| ..| ..     .|       ||||  |   .. . . | ..   .   .  .||||  | ||||  |. ..   .. .   ..|| | . .     
lklnkkssevet..RevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervke..egvlDvfstvsrlRtq

KLQGVTQPSQRRYVHY
.   | .|.| .....
RnimvqrpeqYkfiye
subfamily_PTPRB_pd Subfamily PTPRB 192-273 1.3e-06 22.7 In-house 155-238 (293) alignment 
Range on Protein: 192-273
Range on HMM: 155-238/293.0
KMLKTQHQDNYMVFNLSERSYDISKFNNQVLDFGWPDHLAPSLERL-SIVCKSMKSWL-DSDPNHVVVVHCKGGKGRTGCVIAS
............. .|. .  . ..  .|     ||||  |.  .     .. ..... ..  .. .||||  | ||||  || 
tlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfial
subfamily_DSP11_pd Subfamily DSP11 179-297 2.1e-06 21.8 In-house 35-159 (178) alignment 
Range on Protein: 179-297
Range on HMM: 35-159/178.0
VESAYRNNLKDVAKMLKTQHQDNYMVFNLS--ERSYDISKFNNQVLD---FGWPDHLAPSLERLSIVCKSMKSWLD--SDPNHVVVVHCKGGKGRTGCVI
||.  |   ||. ..|. ....  .| .|.  .| |. ...... .    .  | |  |. | ..  .. .|..|.   | .... |||  |  ||| .|
veeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyli

ASFMNySQICQSASAALDHFAMKRFY
  ..  ..   ... |.. |   | .
Cryli.dvegyepedaieafeearGh
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 191-281 2.3e-06 21.9 In-house 148-241 (318) alignment 
Range on Protein: 191-281
Range on HMM: 148-241/318.0
AKMLKTQHQDNYMV--FNLSERSYDISKFNNQVLDFGWPDHLAPS--LERLSIVCKSmKSWLDSDPNHVVVVHCKGGKGRTGCVIASFMNYSQIC
 .. .. . ..|..  |.....  . |.   |     |||.  |.   . |..| .. ...  .  ....|||| .| ||||  ||  .   .| 
velkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqv.skaqqksgagpivvhCsaGvGrtGvfiavdillerik
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 222-315 2.6e-06 21.7 In-house 177-265 (288) alignment 
Range on Protein: 222-315
Range on HMM: 177-265/288.0
LDFGWPDHLAPS-LERLSIVCKSMKSWldsdpNHVVVVHCKGGKGRTGCVIASFMNYSQICQSASAALDHFaMKRFYDDKLQGVTQPSQRRYVHY
    |.|.  |        ... .||      .. .|||.. | |||| .| ...   ... .   .. .. ...  ... . ..   |  ||| 
hlleWdddgvPenylsplrllevlksl.....qkPivvhssaGvGrtgtlililialeslrlddflgirsl.laklreerfkaiqtemqylyvhr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 149-323 3e-06 20.8 In-house 19-198 (440) alignment 
Range on Protein: 149-323
Range on HMM: 19-198/440.0
GRNRYTDDGFDLDLSYITDRIIAMSFPGSGVESAYRNNLK-DVAKM----LKTQHQDNYMvfNLSERSYDISKFNNQVLDFGWPDHLAPSLERLS-IVCK
 | |  .| . |  | ...     |.| . |.. ||| |  | ...    .|   ...|.  | |  .   |.  .|    ||||.  | .      . .
rrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyi..nasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiq

SMKSWLDSDPNHVVVVHCKGGKGRTGCVIASFMNYSQICQSAsaALDHFAM-KRFYDDKLQGVTQPSQRRYVHY--FEDLLVGK
 ..   .   |  ..|||  | |||| .||      .  .|    .| |.. . . ... | |  | |  .||   .| ||.| 
dvnesqekagngpllvhcsagagrtgviiavdsilreakrsd..qidifsfinsmrnnrpqmvqtpeqyafvheavlegllcgd
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 219-276 3e-06 21.6 In-house 173-231 (281) alignment 
Range on Protein: 219-276
Range on HMM: 173-231/281.0
NQVLDFGWPDHLAPSLERLSI-VCKSMKSWLDSDPNHVVVVHCKGGKGRTGCVIASFMN
.|.    |||| .|.  .  .   | ...  ... .. .|.||  | ||||. ||    
eqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrl
subfamily_PTPN13_pd Subfamily PTPN13 194-275 4.1e-06 21.3 In-house 142-224 (273) alignment 
Range on Protein: 194-275
Range on HMM: 142-224/273.0
LKTQHQDNYMVFNLSERSYDISKFNN-QVLDF-GWPDHLAPSLE--RLSIVCkSMKSWLDsDpNHVVVVHCKGGKGRTGCVIASFM
||.|..|.. | .|  .  . .. .. . |.|  ||||  ||     | .|.  ...  . | .  .||||  | ||.| .|.  .
lkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfva.evrrlqt.d.agPivvhcsaGiGrsGtlitidv
0048567 (Phosphotyrosine protein) phosphatases II 201-275 4.2e-06 21.2 In-house 29-99 (157) alignment 
Range on Protein: 201-275
Range on HMM: 29-99/157.0
NYMVFNLSERsydiSKFNNQVLDFGwpdhlAPSLERLSIVCKSMKSWLD--SDPNHVVVVHCKGGK---GRTGCVIASFM
|...|....       ...   |||      ..| .|   .. ....|.  .  .....|||| |    |||...|....
nalyFsiddg....lvyedfffdfG.....PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 203-285 4.6e-06 20.7 In-house 160-242 (315) alignment 
Range on Protein: 203-285
Range on HMM: 160-242/315.0
MVFNLSERSYDISKFNNQVLDFGWPDHLAPSLE-RLSIVCKSMKSWlDSDPNHVVVVHCKGGKGRTGCVIASFMNYSQICQSAS
.. .|  |  . |.   |    .|||. ..     |  . | .|.  .   .. ..|||  | |||| ||.     .|| .. |
varklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrs
zf-C2H2_4 C2H2-type zinc finger 11-34 4.9e-06 14.3 Pfam-A 1-24 (24) alignment 
Range on Protein: 11-34
Range on HMM: 1-24/24.0
FICPYCLVSFNSSNKLQAHFIDFH
|.||.|  .|.. . |. |..  |
faCplCgktFttreeLrrHlakhH
DSPc Dual specificity phosphatase, catalytic domain 213-295 8.7e-06 20.6 Pfam-A 39-114 (133) alignment 
Range on Protein: 213-295
Range on HMM: 39-114/133.0
DISKFNNQVLDfgwpDHLAPSLERLSIVCKSMKSWldSDPNHVVVVHCKGGKGRTGCVIASFMNYSQICqSASAALDHFAMKR
.| ... .| |    .. .   . |. . . ...    . .. |.|||. |  |....|. .. ... . |.. |....  .|
eieylripved....etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerr
DSPc Dual specificity phosphatase, catalytic domain 213-295 8.7e-06 20.6 In-house 39-114 (133) alignment 
Range on Protein: 213-295
Range on HMM: 39-114/133.0
DISKFNNQVLDfgwpDHLAPSLERLSIVCKSMKSWldSDPNHVVVVHCKGGKGRTGCVIASFMNYSQICqSASAALDHFAMKR
.| ... .| |    .. .   . |. . . ...    . .. |.|||. |  |....|. .. ... . |.. |....  .|
eieylripved....etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerr