Gene AquePTP-Un-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP043_AA protein Get Run
AqueP043_AA_0-98 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-101 2.2e-40 133.7 In-house 187-287 (319) alignment 
Range on Protein: 1-101
Range on HMM: 187-287/319.0
NWPSTSSPNQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
.||    |..|||..||. .. . ..|. .|||.||||.| ||||||.... .|||.| |.|.||||||..||.||.  |.  .||.||..| ||.|...
eWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag

N
.
d
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-103 4.8e-40 132.7 In-house 194-296 (298) alignment 
Range on Protein: 1-103
Range on HMM: 194-296/298.0
NWPSTSSPNQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
.||. . |..|||..||...| . |...|| |..|.||.| ||.|||.|. .||||.|.|||.||| .||.||..||| |.  .|| ||..| ||....|
sWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf

NNY
|..
nde
subfamily_PTPRD_pd Subfamily PTPRD 1-102 5.3e-39 129.3 In-house 186-286 (564) alignment 
Range on Protein: 1-102
Range on HMM: 186-286/564.0
NWPSTSSPNQATSMIDLVADVVRIQrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
.||..  |..|||..||. .| ... ....|||.|||| | ||||||...  .|||.|.|...|....||.|| ||.  |   .|| |||.| ||... .
sWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg

NN
|.
nt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-103 8.9e-36 118.5 In-house 184-286 (318) alignment 
Range on Protein: 1-103
Range on HMM: 184-286/318.0
NWPSTSSPNQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
.|| ...|....|..||| .| ..|.|||.|||.|||| | ||||.|.|. ..|||.|||...||| |||.|| ||.  |   ||||||... ||.....
sWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg

NNY
. .
dte
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-104 9.6e-36 118.2 In-house 146-249 (250) alignment 
Range on Protein: 1-104
Range on HMM: 146-249/250.0
NWPSTSSPNQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
.||  . |..||....|. .| . |...||.|. |.|| | ||.|.|.|. .|||||| |.|.|||  .|.||..||. |.  .|| |.....|......
vWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv

NNYD
..| 
edya
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-101 2.4e-35 117.1 In-house 187-287 (305) alignment 
Range on Protein: 1-101
Range on HMM: 187-287/305.0
NWPSTSSPNQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
.||    |..|||...|. .| . |.|. . |..||||.|.||||.|.|.   |||||.|.|.|||  .|.|| .|.. |.  ||| |.| |  | ....
dWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

N
.
d
0050432 (Phosphotyrosine protein) phosphatases II 1-103 8e-34 112.8 In-house 206-305 (308) alignment 
Range on Protein: 1-103
Range on HMM: 206-305/308.0
NWPSTSSPNQATSMIDLVADVVRIQrksGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
|||  . |.......|..  | . .   ..||| ||||.|.||||||.|. ..||.|..|. .|||..||.|| |||| |.. .||.|...|.||.....
nWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

NNY
 ..
ltk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-103 2.2e-33 110.4 In-house 187-289 (290) alignment 
Range on Protein: 1-103
Range on HMM: 187-289/290.0
NWPSTSSPNQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
||.|| . .. .... ... ....|||.||..| |||||..||...|||. | ... | |.|||||. .|..|||.|| |.  .||..|..  |. ...|
nwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf

NNY
..|
ety
subfamily_PTPRA_pd Subfamily PTPRA 2-96 3.1e-33 110.1 In-house 201-294 (330) alignment 
Range on Protein: 2-96
Range on HMM: 201-294/330.0
WPSTSSPNQATSMIDLVADVVRIQRKSGNgPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
||    | ..  |..|.. | .....|.. ||.|||| | ||||||... .||||.|||...||| .|| || |||  |.   |||||.|. ||.
wPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
0046845 (Phosphotyrosine protein) phosphatases II 1-103 8.3e-33 109.4 In-house 174-280 (284) alignment 
Range on Protein: 1-103
Range on HMM: 174-280/284.0
NWPSTSSPNQATSMIDLVADVVRIQRK-SGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQ---VIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
.||  . | ......... .| ..... .|.||| ||||.|.||||||.|. ..||.|..|.   ..||...|| || ||||.|.  .||.|...|.||.
swpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealley

VNTFNNY
.......
lklkltl
0051299 (Phosphotyrosine protein) phosphatases II 1-97 1.1e-31 105.8 In-house 191-286 (288) alignment 
Range on Protein: 1-97
Range on HMM: 191-286/288.0
NWPSTSSPNQATSMIDLVADVVRIQRkSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|||  . |. .....|.. .| . .. ||.||. ||||.|.||||||.|....||.|..|...||...||.|| |||| |.  .||.|...|.||..
nwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-106 1.9e-31 104.1 In-house 182-287 (287) alignment 
Range on Protein: 1-106
Range on HMM: 182-287/287.0
NWPSTS-SPNQATSMIdLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
||.||   ....|... .. . .. |||.||..| |||||. ||...|||. | ... | | |||||. .|  |||.|| |  ..||.|| .. ||....
nWdstgkvtepqtill.vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

FNNYDNF
|. | .|
fetysdf
0036941 (Phosphotyrosine protein) phosphatases II 1-102 2.7e-31 104.4 In-house 177-282 (297) alignment 
Range on Protein: 1-102
Range on HMM: 177-282/297.0
NWPSTSSPNQATSMIDLVADVVRIQRKS-GNGPITVHCSDGLGRTGTFCAMFTVLERLK---AEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
.||  . |. ..|..|..  | ...... ..||. ||||.|.||.|||.|....|..|.    |. .|....||.|| |||| |   .||.|.. | ||.
gwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel

VNTFNN
......
lkkklt
0040438 (Phosphotyrosine protein) phosphatases II 1-103 6e-31 103.3 In-house 181-282 (317) alignment 
Range on Protein: 1-103
Range on HMM: 181-282/317.0
NWPSTSSPNQATSMIDLVADVVRIQRkSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
.||  . |   ....|..  | . .. ...||. ||||.|.||||||.|....||.|. |. .||...||.|| |||| |   .||.|...|.||.....
gWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

NNY
...
ltl
0039614 (Phosphotyrosine protein) phosphatases II 1-102 7.2e-31 103.2 In-house 192-294 (297) alignment 
Range on Protein: 1-102
Range on HMM: 192-294/297.0
NWPSTSSPNQATSMIDLVADVVRIQRKS-GNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
.||  . |. ........  | ...... ..||. ||||.|.||||||.|....||.|. |. .||...||.|| |||| |   .||.|...|.||....
gwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

FNN
...
klt
0047943 (Phosphotyrosine protein) phosphatases II 1-97 2.6e-30 101.2 In-house 175-272 (273) alignment 
Range on Protein: 1-97
Range on HMM: 175-272/273.0
NWPSTSSPNQATSMIDLVADVVRIQRKS-GNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
.||  . | . .|..... .| ...... .|||. ||||.|.||||||.|....|..|..|. .||...|| || |||| |   .||.|...|.||..
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 1-99 3e-30 100.4 In-house 191-288 (307) alignment 
Range on Protein: 1-99
Range on HMM: 191-288/307.0
NWPSTSSPNQATSMIDLVADVVRIQRKSgNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
.|. .  |..|.....|.  |  ..... ..||.|||| | ||.|.| |.  .|..||||. .|.| ||| || ||. .|. ..||.|...| |.. . 
gWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
DSPc_SM00195 1-97 3.4e-30 100.6 In-house 167-262 (263) alignment 
Range on Protein: 1-97
Range on HMM: 167-262/263.0
NWPSTSSPNQATSMIDLVADVVRIQRKSgNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|||  . |....|...|.  |   ...| .||| ||||.|.||||||... ..|..|..|. .|.|..|| || |||| |.  .|| ||..|.||..
nWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1-97 3.4e-30 100.6 In-house 167-262 (263) alignment 
Range on Protein: 1-97
Range on HMM: 167-262/263.0
NWPSTSSPNQATSMIDLVADVVRIQRKSgNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|||  . |....|...|.  |   ...| .||| ||||.|.||||||... ..|..|..|. .|.|..|| || |||| |.  .|| ||..|.||..
nWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 1-97 4e-30 100.6 In-house 182-277 (278) alignment 
Range on Protein: 1-97
Range on HMM: 182-277/278.0
NWPSTSSPNQATSMIDLVADVVRIQRkSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
.||  . | . ....|.. .| .... . |||. ||||.|.||||||.|....||.|. |. .|....||.|| |||| |   .||.|...|.||..
gwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPRK_pd Subfamily PTPRK 2-95 4.6e-30 99.5 In-house 183-275 (314) alignment 
Range on Protein: 2-95
Range on HMM: 183-275/314.0
WPSTSSPNQATSMIDLVADVVRIQRKsGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
||.   |..||....||. |   | . ..|.| |||| | ||||||.|. .||. .. |.|.||| .||||| ... .|.  .|| ||. ..||
WpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
Y_phosphatase Protein-tyrosine phosphatase 1-95 1.8e-29 98.2 Pfam-A 142-235 (235) alignment 
Range on Protein: 1-95
Range on HMM: 142-235/235.0
NWPSTSSPNQATSMIDLVADVVRIQrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
|||  . |....|..||. .| . . .. .||..||||.| ||||||.|. ..||.|.||. .||...||.|| |||| |....||.|..|| ||
nWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1-95 1.8e-29 98.2 In-house 142-235 (235) alignment 
Range on Protein: 1-95
Range on HMM: 142-235/235.0
NWPSTSSPNQATSMIDLVADVVRIQrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
|||  . |....|..||. .| . . .. .||..||||.| ||||||.|. ..||.|.||. .||...||.|| |||| |....||.|..|| ||
nWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0045450 (Phosphotyrosine protein) phosphatases II 1-97 2.2e-29 98.6 In-house 204-304 (307) alignment 
Range on Protein: 1-97
Range on HMM: 204-304/307.0
NWPSTSSPNQATSMIDLVADVVRIQRKS-GNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQV---IDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
.|| .. |    ...|..  | ...... ..||. ||||.|.||||||.|....|..|..|..   .|....||.|| |||| |   .||.|...|.||.
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

V
.
l
0042113 (Phosphotyrosine protein) phosphatases II 1-97 4.4e-29 97.0 In-house 147-243 (245) alignment 
Range on Protein: 1-97
Range on HMM: 147-243/245.0
NWPSTSSPNQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
.||  . |.   ...|..  | .......|||. ||||.|.||||||.|....||.|..|. ......|| || |||| |   .||.|...|.||..
pwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
PTPc_DSPc_SM00012 1-95 1.4e-28 94.6 In-house 9-105 (105) alignment 
Range on Protein: 1-95
Range on HMM: 9-105/105.0
NWPSTSSPNQATSMIDLVADVVRIQRKSG-NGPITVHCSDGLGRTGTFCAMFTVLERLKAE-QVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
.|| .. |....|...|...| . ..||. ..|. ||||.| ||||||.|. ..|..|..| . .|.| .|| || |||| |.  .|| |...| ||
gwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyralle
0040439 (Phosphotyrosine protein) phosphatases II 1-97 2e-28 95.1 In-house 149-246 (249) alignment 
Range on Protein: 1-97
Range on HMM: 149-246/249.0
NWPSTSSPNQATSMIDLVADVVRIQRKS-GNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
.|| .. |    ...|..  |  ....   .||. ||||.|.||||||.|....||.|. |. .|....||.|| |||| |   .||.|...|.||..
dwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2-97 5.7e-28 92.8 In-house 185-279 (288) alignment 
Range on Protein: 2-97
Range on HMM: 185-279/288.0
WPSTSSPNQATSMIDLVAdVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|| .. |.... ...|.   | .. ..  |||.||||.|.|||||| |. ........|..|||..||. || ||. .|.   |||||... |. .
WpdhgvPeskapllellr.qvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0045098 (Phosphotyrosine protein) phosphatases II 1-101 9.5e-28 92.8 In-house 163-276 (278) alignment 
Range on Protein: 1-101
Range on HMM: 163-276/278.0
NWPSTSSPNQA--TSMIDLVADVVRIQR------------KSGNGPITVHCSDGLGRTGTFCAMFTVLERLkaEQVIDVFSTVKTLRIQRPG-FVNDIDQ
.||  ..|..   .|...|.  . . ..             ...||. |||| |.|||||..|....||.|  |...|....||.|| ||||  |   .|
pwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleq

YEFIHKAALEFVNTFN
|.|.....||... ..
yrflyefllelllrgk
subfamily_PTPRG_pd Subfamily PTPRG 1-101 2.5e-27 90.3 In-house 192-291 (563) alignment 
Range on Protein: 1-101
Range on HMM: 192-291/563.0
NWPSTSSPNQATSMIDLVADVVRIqRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
.|| ...|....  .  |    .  .|.  |||.|||| | |||||.... |.|.....|....|| ..|..| ||.  |....|| |.|.| || ... 
kWPdhgvPehslpvLifvkkssaa.nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask

N
.
e
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1-98 3.9e-27 90.0 In-house 170-269 (274) alignment 
Range on Protein: 1-98
Range on HMM: 170-269/274.0
NWPSTSSPNQATSMIDLVADVVRI--QRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
.|| . ||..|....|||..| .   ...   .|. |||| |.|||| | |.   . .|..|.|.||...|  ||..| | |.  .|||.||.|  ....
dWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-96 5.3e-27 89.6 In-house 185-278 (315) alignment 
Range on Protein: 2-96
Range on HMM: 185-278/315.0
WPSTSSPNQATSMIDLVADVVRIQRKSGnGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
|| .  |. ......|.  | . . .|  |.| ||||.| ||||||... .||....||..|||.  .. .| .| . |. ..||.||..| || 
wpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 9-103 5.4e-27 89.3 In-house 205-299 (301) alignment 
Range on Protein: 9-103
Range on HMM: 205-299/301.0
NQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFNNY
 .   ..  . ||.  |.| | ||. |||||. .|.|..|..   ||  ||| |.|||  .|..| ..|| |  ..|| .|...  ....  . |
reprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_PTPN12_pd Subfamily PTPN12 1-98 1.6e-26 87.9 In-house 179-278 (290) alignment 
Range on Protein: 1-98
Range on HMM: 179-278/290.0
NWPSTSSPNQATSMIDLVADVVRIQRkSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQV---IDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
.||    |..|.|...|...| ..|. | . |. |||| | ||||| .|.  | | ||||..   .|||. | .|| ||.  |   .|||...|| .|.|
aWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

N
.
q
subfamily_PTPRB_pd Subfamily PTPRB 2-99 1.6e-26 88.1 In-house 189-287 (293) alignment 
Range on Protein: 2-99
Range on HMM: 189-287/293.0
WPSTSSPNQATSMIDLVADVVR-IQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
||    |.......|.|  | . |.... ..||.|||| |.|||||| |. ..|.... |...|.|..|  || .|  .|   .|| |||.. |.....
WpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 12-96 1.7e-26 87.8 In-house 182-265 (283) alignment 
Range on Protein: 12-96
Range on HMM: 182-265/283.0
TSMIDlVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
 |..  .  |.  |..| .||| |||| | |||..|.|. . .. ...| |.|||..|| .| ||.. |   ||| ..|...|| 
nslvk.fnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-95 1.8e-25 85.0 In-house 195-289 (319) alignment 
Range on Protein: 2-95
Range on HMM: 195-289/319.0
WPSTSSPNQATSMIDLVADVVRIQRK-SGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
||    |.... .. ||  |  ...|  .. .| |||| | ||||.. .. ..|.|.| |. .||. .|. || ||. .|.|. || ||. | ||
wpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN13_pd Subfamily PTPN13 1-99 2.3e-25 84.4 In-house 175-271 (273) alignment 
Range on Protein: 1-99
Range on HMM: 175-271/273.0
NWPSTSSPNQATSMIDLVADVVRIQRksGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
.||  . |..|.... .|| | |.|.   .||| |||| |.||.||. .. .||. .. .. .||  .|..|| || | |   ||| |..||.|| ...
kwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
0037934 (Phosphotyrosine protein) phosphatases II 1-96 2.6e-25 84.8 In-house 142-241 (243) alignment 
Range on Protein: 1-96
Range on HMM: 142-241/243.0
NWPSTSSPNQATSMIDLVADVVRIQRK-------SGNGPITVHCSDGLGRTGTFCAMFTVLERLkaeQvIDVFSTVKTLRIQRPG-FVNDIDQYEFIHKA
.||  . |.  ....|.. .|  ....       ...||. |||| |.|||||..|....|..|   . .|....||.|| ||||  |   .||.|...|
pwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyea

ALEF
.||.
llel
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-95 4.3e-25 83.8 In-house 159-253 (284) alignment 
Range on Protein: 2-95
Range on HMM: 159-253/284.0
WPSTSSPNQATSMIDLVADVVRIQRK-SGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
||    |.... .. ||  |  ...|  .. .| |||| | ||||.. .. ..|.|.| |. .||. .|. || ||. .|.|. || ||. | ||
wpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0036282 (Phosphotyrosine protein) phosphatases II 1-91 2.2e-24 81.5 In-house 76-164 (174) alignment 
Range on Protein: 1-91
Range on HMM: 76-164/174.0
NWPSTSSPNQATsMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKaEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHK
.||  . |. .. ....|  | ... ....||. |||| |.|||||..|.. .| .|. | ..|....|..|| |||| |   .||.|...
pwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_CG7180_pd Subfamily CG7180 2-102 1.1e-23 78.3 In-house 190-295 (296) alignment 
Range on Protein: 2-102
Range on HMM: 190-295/296.0
WPS-TSSPNQATSMIDLVADVVRIQRKS----GNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
|..  . |  ....|.|.  |  ...|      .||. |..||| .|.| ..|.   || .. |. .|||  |||||..||. |. ...| .|    ||.
WeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

VNTFNN
| .. .
vlcnkd
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-99 1.5e-23 78.3 In-house 179-278 (281) alignment 
Range on Protein: 1-99
Range on HMM: 179-278/281.0
NWPSTSSPNQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAE-QVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
.|| .  |.... ...  ..| ....|. . |. .||| | |||||. |. .......|| . .||  .|. || .|  .|  . ||||..|| |. .. 
aWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 11-98 2.8e-23 77.6 In-house 203-289 (325) alignment 
Range on Protein: 11-98
Range on HMM: 203-289/325.0
ATSMIDLVADVVRIQrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
 . ... | . |. .   . .|| ||||.|.||||.| .....|...  |  .|.|  || || .||  |. .||| .|..|  |.. 
ilqlvkavservtan.tkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-98 4.1e-23 76.7 In-house 182-278 (315) alignment 
Range on Protein: 1-98
Range on HMM: 182-278/315.0
NWPSTSSPNQATSMIDLVADVvRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
.||   ...|..|.. |. .| . .... . .. |||| | |||| ....  |....| ....||| .||.|| .|| .|.  ..| ||. | || . 
ewPdkGvdkqtssllklikev.kadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
0051429 (Phosphotyrosine protein) phosphatases II 16-100 6.5e-23 77.2 In-house 138-228 (272) alignment 
Range on Protein: 16-100
Range on HMM: 138-228/272.0
DLVADVVRIQRKsgNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVID--------VFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
. . ..... ..  .||. |||| | .||||..|.. .|... .|...|        .. .|. || ||||.| . .||.|...|.||.....
eallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-99 1.3e-22 75.2 In-house 186-286 (297) alignment 
Range on Protein: 1-99
Range on HMM: 186-286/297.0
NWPSTSSPN--QATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
.||. . ..  .|.|...|. .|     .  .||. |||. |.|||| ....  |. . | |. .|.| .|| || .|| .|   .||.|...| ||.. 
eWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall

T
.
s
subfamily_PTPN9_pd Subfamily PTPN9 8-98 1.4e-22 75.1 In-house 189-291 (297) alignment 
Range on Protein: 8-98
Range on HMM: 189-291/297.0
PNQATSMIDLVADVVRIQ------------RKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
|..|.|..|..  | . |             .  . || |||| |.||||||...   |.||. ....||. |||.|| ||   .   .|||| ..| ||
PssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

FVN
.  
yal
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 17-97 3.5e-22 73.7 In-house 179-259 (267) alignment 
Range on Protein: 17-97
Range on HMM: 179-259/267.0
LVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|.. . . | . || |. |.||||.||.|||  . . |||.| |.| |.|  .. .| ||.|.|.  ..| .||.   |. 
lfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_PTPN6_pd Subfamily PTPN6 1-102 3.6e-22 73.7 In-house 195-302 (306) alignment 
Range on Protein: 1-102
Range on HMM: 195-302/306.0
NWPSTSSPNQATSMIDLVADVVRIQRKSG---NGPITVHCSDGLGRTGTFCAMFTVLERLK---AEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAAL
.||  . |..   ..|.. || | |...    .||| ||||.|.||||||  . ..|. ..    .  ||. ..||..| || |.|.  .|| |..||  
sWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik

EFVNTFNN
....| ..
kyietkkk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2-100 1.1e-21 72.0 In-house 162-267 (270) alignment 
Range on Protein: 2-100
Range on HMM: 162-267/270.0
WPSTSSPN------QATSMIDLVADVVRIQRKSGNG-PITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAAL
||  . |.      ...... ....| | ...  .. |. ||||.|.|||||. |. .... |. .. .|| . .. || .|. .|.  .||||..|| .
WpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv

EFVNTF
|.... 
eyaerr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-98 1.6e-21 71.0 In-house 181-277 (515) alignment 
Range on Protein: 1-98
Range on HMM: 181-277/515.0
NWPSTSSPNQATSMIDLVADVvRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
.||   .|....|.. |. .| . ..   . |. .||| | |||| ....  |. . |  ...||| .|. .| .|| .|   .|| ||. | || . 
eWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
0043147 (Phosphotyrosine protein) phosphatases II 2-91 2.3e-21 71.7 In-house 73-155 (172) alignment 
Range on Protein: 2-91
Range on HMM: 73-155/172.0
WPSTSSPnQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLerlkaeQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHK
||  . |  .  .....  . ... .| .||. |||| |.|||||..|.. .|      . .... .|...| .||| |   .|| |...
wpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrflyy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2-97 4.1e-21 69.9 In-house 184-279 (439) alignment 
Range on Protein: 2-97
Range on HMM: 184-279/439.0
WPSTSSPNQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
||    | ||. ..|..  .   . |   ||. |||| |.|||||  |.   ||.||.|. .|.   || || ||  .|... || ||..| || .
wpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
0041856 (Phosphotyrosine protein) phosphatases II 1-98 5.3e-21 70.5 In-house 86-172 (182) alignment 
Range on Protein: 1-98
Range on HMM: 86-172/182.0
NWPSTSSPNqatsmIDLVADVVRIQRKsGNGPITVHCSDGLGRTGTFCAMFTVLERlkaeQvIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
.||  . |.     .| . | ... ..  .||. |||| |.|||||..|.. ....    . ......||..| .||| |   .|| |.. |.||.. 
pwpDhgvpd.....ldelldfieevle.eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2-97 6.3e-21 69.2 In-house 99-194 (440) alignment 
Range on Protein: 2-97
Range on HMM: 99-194/440.0
WPSTSSPNQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
||  . |. |  .. .. ||   | |.||||. |||| | ||||   |. ..|   |  . ||.|| ....| .|| .|.  .|| |.|.| || .
wpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegl
subfamily_PTPRN_pd Subfamily PTPRN 2-99 1.3e-20 68.3 In-house 197-294 (297) alignment 
Range on Protein: 2-99
Range on HMM: 197-294/297.0
WPSTSSPNQATSMIDLVADVVRIQRKsGNGPITVHCSDGLGRTGTFCAMFTVLERL-KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
||... | .| |....   | .  |     || |||||| ||||.....  ||.|| |  . ||. .|.. || ||||.|.  ||.||. .|  | ||.
wpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevna
0046846 (Phosphotyrosine protein) phosphatases II 1-96 1.7e-20 68.9 In-house 83-172 (176) alignment 
Range on Protein: 1-96
Range on HMM: 83-172/176.0
NWPSTSSPNQaTSMIDLVADVVRIQRKSgnGPITVHCSDGLGRTGTFCAMFtvleRLKAEQVIDVFSTVKTLRIQRP-GFVNDIDQYEFIHKAALEF
.||  . |.  . ...|.. . . ...   ||. |||| |.|||||..|..     |. |. ..|. .....| ||| | |   .||.|.....|..
pwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefelll
0049260 (Phosphotyrosine protein) phosphatases II 2-91 1.7e-20 68.7 In-house 62-144 (152) alignment 
Range on Protein: 2-91
Range on HMM: 62-144/152.0
WPSTSSPNQATSMIDLVADVVRIqRKSGNGPITVHCSDGLGRTGTFCAMFTVLerlkaeQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHK
||  . |. .  ...|.  . .. ... .||. |||| |.|||||..|.. .|      . .... .|. .| .||| |   .|..|...
wpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPN3_pd Subfamily PTPN3 1-95 2e-19 64.6 In-house 180-273 (280) alignment 
Range on Protein: 1-95
Range on HMM: 180-273/280.0
NWPSTSSPNQATSMIDLVADvVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
.||  . |.........|   || .|.. . |. |||| |.|||| . .. | |  . |.. . .   |.|.| ||  .|.  .||.|. .| |.
aWpdhgvPddsadflefver.vrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
0048076 (Phosphotyrosine protein) phosphatases II 1-96 6.3e-19 63.5 In-house 54-142 (145) alignment 
Range on Protein: 1-96
Range on HMM: 54-142/145.0
NWPSTSSPNQATSMIDLVADVVRIQRKsGnGPITVHCSDGLGRTGTFCAMFTVLErlkaEQvIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
.||  . |. .  ...... . ..... | ||. |||| |.|||||..|.. .|.    .. ........ .| ||||.|   .|..|.... ||.
pwpDhgvpdllellleflefieealke.g.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefelel
0051082 (Phosphotyrosine protein) phosphatases II 12-93 6.8e-19 63.4 In-house 74-149 (151) alignment 
Range on Protein: 12-93
Range on HMM: 74-149/151.0
TSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERlkaeqvIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAA
  ..| |...... .. .|||. |||| |.|||||..|.. .|..      ........ .|..|||.|.  .|. |...| 
plsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_PTPN23_pd Subfamily PTPN23 2-102 6.9e-19 62.7 In-house 181-285 (288) alignment 
Range on Protein: 2-102
Range on HMM: 181-285/288.0
WPS---TSSPNQATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQ-VIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
||.    .||..   ..| | .  . ...  . |. |||| | ||||.|. ...... |.... ..|.   |..|| ||   |.. .|..|  .| || .
WpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

NTFNN
.  ..
rrvld
0049772 (Phosphotyrosine protein) phosphatases II 2-102 8.6e-19 63.8 In-house 188-285 (314) alignment 
Range on Protein: 2-102
Range on HMM: 188-285/314.0
WPStSSPNQATSMIDLVADVVRIqrkSGNGPITVHCSDGLGRTGTFCAMFTVLERLKaeqViDVFSTVKTLRIQRP-----GFVNDIDQYEFIHKAALEF
.|   |..    . .... . .    . .||. |||..| ||||||...  .. .|.   | ..  ... .| .||     ||..  .|||||..| ||.
vpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg...v.sleealedvrlkRpinpnpgfieqleqyefilealley

VNTFNN
.... .
lkflkk
subfamily_CG42327_pd Subfamily CG42327 22-98 1.8e-18 61.3 In-house 239-316 (319) alignment 
Range on Protein: 22-98
Range on HMM: 239-316/319.0
VRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAE-QVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
 |  ... .||..|||||| ||||.  |    ...|.   . .|.  .|  .| .|   | ...|||||.| . |. .
srsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
0048179 (Phosphotyrosine protein) phosphatases II 1-91 2.5e-18 61.6 In-house 56-139 (144) alignment 
Range on Protein: 1-91
Range on HMM: 56-139/144.0
NWPSTSSPNQATSMIDLVADVVRIQRksGNGPITVHCSDGLGRTGTFCAMFTVLerlkAEQvIDVFSTVKTLRIQRPGFVNDIDQYEFIHK
.||  . |. .. ...... . ....   .||. |||| |.|||||..|.. ..     .. ........ .| .||| |   .|..|...
pwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2-95 6.3e-18 59.8 In-house 146-238 (239) alignment 
Range on Protein: 2-95
Range on HMM: 146-238/239.0
WPSTSSPNQATSMIDLVADVVRiQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
||    |. ||... |   . . .   |  |  .||| |.||||.|  . ..| . | .. .|.|  ||..| .|| .|.  .|| ||| | ||
wpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2-95 8.7e-18 59.3 In-house 147-239 (239) alignment 
Range on Protein: 2-95
Range on HMM: 147-239/239.0
WPSTSSPNQATSMIDLVADVVRiQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
||    |. ||... |   . . .   |  |  .||| |.||||.|  . ..| . | .. .|.|  ||..| .|| .|.  .|| ||| | ||
wpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
0044763 (Phosphotyrosine protein) phosphatases II 2-95 1.6e-17 59.2 In-house 83-169 (178) alignment 
Range on Protein: 2-95
Range on HMM: 83-169/178.0
WPSTSSPNqATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERlkaeQViDVFSTVKTLRIQRPgFVNDIDQYEFIHKAALE
.|  . |.  ..... . . ..  ... .||. |||| |.||.||..|.. ....    .. .... .. .| .|| .|   .|...... .|.
ipDhgvpd.llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2-95 2.8e-17 57.7 In-house 143-237 (237) alignment 
Range on Protein: 2-95
Range on HMM: 143-237/237.0
WPSTSSPNQATSMIDLVADVVRIQRK-SGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
||    |.|..... .  ...   .. |  ||  .||| |.|||| |  . ..| . | ..|.|..  |...  .||  ..  ||| |||.. ||
wpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-99 5.3e-17 56.5 In-house 177-279 (287) alignment 
Range on Protein: 1-99
Range on HMM: 177-279/287.0
NWPSTSSPNQATSMIDLVADV---VRIQRK-SGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
.||. . .  | ..| .| ||   . ..|. |. ||. ||.. |.||.|.. |......||.    .||  .|  || .| ..|. . |. .. .|   .
swPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty

VNT
 .|
ykt
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 35-95 5.4e-17 55.9 In-house 2-62 (69) alignment 
Range on Protein: 35-95
Range on HMM: 2-62/69.0
VHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
|||| | |||||| |.   . |.|.|...|.|  |. .|  ||  | . ..| ||| |  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 34-95 5.9e-17 55.8 In-house 2-63 (69) alignment 
Range on Protein: 34-95
Range on HMM: 2-63/69.0
TVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
 |||| | |||||| |..  . |.|.|...|.|  |. .|  ||  | .  .| ||| |  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1-98 4.1e-16 53.3 In-house 190-286 (302) alignment 
Range on Protein: 1-98
Range on HMM: 190-286/302.0
NWPSTSSPNQATSMIDLVADVvRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
||.... | . ...|  .|.|   .  ... .. .    | || |.| ......|.|....   .  .||..| |||  |. ..|| ... |.| .. 
nWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2-99 6.5e-16 52.7 In-house 142-387 (392) alignment 
Range on Protein: 2-99
Range on HMM: 142-387/392.0
WPSTSSPNQATS----------------------------------------------------------------------------------------
||    |....|                                                                                        
wPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrnt

------------------------------------------------------------MIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTV
                                                            .. |.  |     .  .  | |||  | |||| ||.    
lipvvhftdhlqdlstssdGdvrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctamec

LERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
. ..   . .|.| ||| || .|  ||.  ..| |...   |.. |
iaqiaegdsvdifqtvkilradrmqfvqteeeyafvydvireylht
subfamily_PTPN14_pd Subfamily PTPN14 2-98 1.2e-15 52.3 In-house 193-297 (300) alignment 
Range on Protein: 2-98
Range on HMM: 193-297/300.0
WPSTSSPNQATSMIDLVADVVRIQR--------KSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAA
||    |.  ..... . .|  ..|        |. . |. ||||.| ||||       ... |. ...||. .....|| ||  .|. . ||.|..|. 
WpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl

LEFVN
.....
ikylk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2-101 3.1e-14 47.3 In-house 193-287 (290) alignment 
Range on Protein: 2-101
Range on HMM: 193-287/290.0
WPSTSSPNQATSMIDlvadVVRIQRKSgNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFN
||  | .. . ...     ..|| ||  .||..|||| |.|||||| |. . |. |   . .|.  .|..||  | . |.   ||  . .. |..   |.
wpdksvalstlallr....tlrilrka.sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1-99 4e-14 47.1 In-house 195-289 (305) alignment 
Range on Protein: 1-99
Range on HMM: 195-289/305.0
NWPSTSSPNQATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFS-TVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
.||    |   .....|...      ..  |||.|||| |.||||.   .  .|..| | |.|.     .. .| ||   ..  .|| |.|.  |.... 
dwpdrgvpaadlailelleka.....rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1-97 7.3e-14 46.5 In-house 185-277 (307) alignment 
Range on Protein: 1-97
Range on HMM: 185-277/307.0
NWPSTSSPNQATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFTVLERL-KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|||    |.   . |.|.  |     .  . |. |||| |.||.||  |.  | ... . .   |.   |. || ||.  ...  || ..|.  ||. 
nwpdrgvpqinltainlleav.....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_PTPN1_pd Subfamily PTPN1 2-98 9.1e-14 45.8 In-house 172-272 (290) alignment 
Range on Protein: 2-98
Range on HMM: 172-272/290.0
WPSTSSPNQATSMIDLVADVVRIQR-KSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQV---IDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
||  . |.  ....... .| .    .|  ||  .||| |.||.|||| . |.| ......    .|.  ..  || .| |..   || .| . | || .
wpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa

N
.
k
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2-97 3.1e-13 44.0 In-house 198-289 (305) alignment 
Range on Protein: 2-97
Range on HMM: 198-289/305.0
WPSTSSPNQATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAE-QVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
||    |    . ..|.. .     .  . || |||| |.|||||  |.  .||..  . ..  .   ||.|| ||   ...  || |||.  |...
wpdrgvppckltslellsai.....rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 14-97 3.7e-13 44.0 In-house 213-295 (297) alignment 
Range on Protein: 14-97
Range on HMM: 213-295/297.0
MIDLVADVVRIQrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|. |  . .| . .  | .. |||| |.||.|      ..|..|. ... || . .. || ||.  |. ..|.|....|.|. .
mvflqleslrae.mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
0038934 (Phosphotyrosine protein) phosphatases II 14-86 6.3e-12 41.0 In-house 99-172 (194) alignment 
Range on Protein: 14-86
Range on HMM: 99-172/194.0
MIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVL-ERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQY
. . .  | .. ... .| . |||  |||||||..| . .   ...||. |. |. ..   |......... ..
llrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2-96 1.4e-11 38.9 In-house 177-269 (285) alignment 
Range on Protein: 2-96
Range on HMM: 177-269/285.0
WPSTSSPNQATSMIDLVADVVRIQRKsgNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
||   .|..|  ||.|   | ... |  . || |||| |.||| ||  .     |.  .  |...  |. .|  |   |.   |. |..   .|.
wpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1-97 1.5e-11 38.9 In-house 180-271 (288) alignment 
Range on Protein: 1-97
Range on HMM: 180-271/288.0
NWPSTSSPNQATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
.|.  . |..  | . |.  .     || . || ||.| | |||||.  .. .|| |. .  . . | .. || .|   ..   || ..|.  || .
eWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 5-91 3.9e-11 37.5 In-house 107-197 (198) alignment 
Range on Protein: 5-91
Range on HMM: 107-197/198.0
TSSPNQATSMIDLVA--DVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERL--KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHK
 ..|| |  .  .||  .| .   .  . |. |||||| | || | |.   .         |.|.|   | ||  | | .  ...|.||..
kttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 5-91 4e-11 37.5 In-house 108-198 (199) alignment 
Range on Protein: 5-91
Range on HMM: 108-198/199.0
TSSPNQATSMIDLVA--DVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERL--KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHK
 ..|| |  .  .||  .| .   .  . |. |||||| | || | |.   .         |.|.|   | ||  | | .  ...|.||..
kttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 27-96 5.4e-11 36.8 In-house 259-343 (350) alignment 
Range on Protein: 27-96
Range on HMM: 259-343/350.0
KSGNGPITVHCSDGLGRTGTFCAMFTVLE------RLK--------AEQVID-VFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
..   || |||| | |||||....  .|.       |.        | .. | .. .|. || ||   | ..||. ||..|.| .
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
subfamily_CDC14_pd Subfamily CDC14 17-90 5.8e-10 33.5 In-house 251-318 (328) alignment 
Range on Protein: 17-90
Range on HMM: 251-318/328.0
LVADVVRIQRKSgNGPITVHCSDGLGRTGTFCAMFTVLE-RLKAEqvidvfSTVKTLRIQRPGFVNDIDQYEFIH
.|   ..|  |. .| |.|||  |||||||. | . . . |. |.       ..  ||| ||| |    |  ...
ivkkfleiaeka.eGaiavhCkaGLGrtGtLiacylmkhyrftaa......eaiawlricrPGsvigpqqkflee
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2-86 1.2e-09 32.3 In-house 191-270 (301) alignment 
Range on Protein: 2-86
Range on HMM: 191-270/301.0
WPSTSSPNQATSMIDLVadvvRIQRKSgNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQY
|.    |.  . . ||.     . .|| . || ||||.|.||. .| .   .  ...|.. |..  ..| || .|   |.   | 
wtdrgvPkshaelfdlm....elvkks.ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_PTPDC1_pd Subfamily PTPDC1 15-87 1.7e-09 32.4 In-house 98-172 (182) alignment 
Range on Protein: 15-87
Range on HMM: 98-172/182.0
IDLVADVVRIQRK-SGNGPITVHCSDGLGRTGTFCAMFTVL-ERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYE
.. . |.|..      .| ..|||  ||||||   | . |  .||.||. |..    ..  ||  . |. . ...
leriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefa
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2-89 2.7e-09 30.9 In-house 198-280 (302) alignment 
Range on Protein: 2-89
Range on HMM: 198-280/302.0
WPSTSSPNQATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFI
||   .|..| . .|..        .|    . |||| |.|||||. |.   ..  . ..| |. | |. .|  | | |.| .|  ..
wpdhGapkeaytaldilkfc.....esykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 29-98 3.2e-09 30.6 In-house 264-345 (349) alignment 
Range on Protein: 29-98
Range on HMM: 264-345/349.0
GNGPITVHCSDGLGRTGTFCAMFTVLE---RL---------KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
   .. |||| | ||||... .  .|.    |         .| .   .. .| .|| ||   |... |. .|..| |....
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2-100 5e-09 30.2 In-house 177-272 (281) alignment 
Range on Protein: 2-100
Range on HMM: 177-272/281.0
WPSTSSPNQATSMIDLVAdvvRIQRKSgnGPITVHCSDGLGRTGTFCAMFTVLERLKAEQV-IDVFSTVKTLRIQ-RPGFVNDIDQYEFIHKAALEFVNT
||    |. .  |. ..    .|. .|   |  .||| |.||.||. |.   |. ...     |.   |  ||.  |   |. ..|| .| |  |.|  .
wpdwqvpessevmlkilr...kirars..tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgva

F
.
y
subfamily_DSP23_pd Subfamily DSP23 18-91 9.6e-09 30.0 In-house 70-140 (148) alignment 
Range on Protein: 18-91
Range on HMM: 70-140/148.0
VADVVRIQR--KSGNGPITVHCSDGLGRTGTFCAMFTVLERlkaeqVIDVFSTVKTLRIQRPGFVNDIDQYEFIHK
| . ||.    .. |  ..|||  | |||||. | . | ||      .    ..  .| .||| |. ..| . ...
vvefvrvveeaeekneavsvhcllgrgrtgtmlacylvker.....klaaaeaiaevrrlrpgsvetveqeklvrd
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2-103 1.6e-08 28.7 In-house 186-282 (312) alignment 
Range on Protein: 2-103
Range on HMM: 186-282/312.0
WPSTSSPNQATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFN
||    |.   .   |.. |     |  . |.  ||| |.|||||.. . ...  |.  .  .|  .   || .|   |. . || .  .. |||. .  
wpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg

NY
 |
ly
PTEN_1 19-70 7.2e-08 27.5 In-house 118-171 (196) alignment 
Range on Protein: 19-70
Range on HMM: 118-171/196.0
ADVVRI-QRKSGNGPITVHCSDGLGRTGTFCAMFTVLER-LKAEQVIDVFSTVK
...    .... .. . |||  ||||.|| .|.. .  . | |.. .. .    
ksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekR
subfamily_DSP11_pd Subfamily DSP11 12-85 8.5e-08 26.3 In-house 99-172 (178) alignment 
Range on Protein: 12-85
Range on HMM: 99-172/178.0
TSMIDLVADVVRIQrKSGNGPITVHCSDGLGRTGTF-CAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQ
..... | . .  . |  .  |.||| .|. ||| . |  .   | ...|. |..|....   ..|  ...|. .
kkfkeavkeflekn.kdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2-94 9.1e-08 26.6 In-house 168-256 (290) alignment 
Range on Protein: 2-94
Range on HMM: 168-256/290.0
WPSTSSPNQATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLK-AEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAAL
| ... ...  ....|.  |     |  . |. ||| ||. |  .. |.      .   .. . . . .|.|| ||   . .  .. |.  ...
Wnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
0048567 (Phosphotyrosine protein) phosphatases II 28-89 9.4e-08 26.6 In-house 72-131 (157) alignment 
Range on Protein: 28-89
Range on HMM: 72-131/157.0
SGNGPITVHCSDGL---GRTGTFCAMFTVLE-RLKAEQVIDVFstvktlRIQRPGFVNDIDQYEFI
  ...| |||. ||   |||.|... . .|  .. .|..|. .      || |||.|   |.. ..
lagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiapl......rivrpgsvpfrdasyll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1-98 1.4e-07 25.4 In-house 199-291 (310) alignment 
Range on Protein: 1-98
Range on HMM: 199-291/310.0
NWPSTSSPNQATSMIdlvADvvRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
||| .  |..    .    .  |.  .   ||  |||| | .|... .|.   ...|.  . .|.   .  |. .|   ..   || .|..  . |. 
nwpdrgvpdekchtv...pq..rllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar
subfamily_ptpA1_pd Subfamily ptpA1 25-57 2.3e-07 24.9 In-house 224-256 (418) alignment 
Range on Protein: 25-57
Range on HMM: 224-256/418.0
QRKSGNGPITVHCSDGLGRTGTFCAMFTVLERL
     | || |||| |.|||||||.   ....|
pssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2-104 4e-07 24.4 In-house 126-228 (255) alignment 
Range on Protein: 2-104
Range on HMM: 126-228/255.0
WPSTSSPNQATSmidlVADVVRIQRKSgnGPITVHCSDGLGRTGTFCAMFTVLE----RLKAEQ--VIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
|.   .|..|      .  .... |.|   .. |||| | ||. .|  .  |       |.  .   .|  | .. || .|.. ...  |  |     |.
WieknaPelare....ilnilkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

FVNTFNNYD
.|   ....
lvfpkgele
DSPc Dual specificity phosphatase, catalytic domain 13-86 4e-07 25.0 Pfam-A 57-130 (133) alignment 
Range on Protein: 13-86
Range on HMM: 57-130/133.0
SMIDLVADVVRiQRKSGNGPITVHCSDGLGRTGTFCAMFTVL-ERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQY
. .. . .... . .. .. . |||  |. |..|.....    ..|.... .....  .    .. ||.  . .|
keleeavefie.kaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLley
DSPc Dual specificity phosphatase, catalytic domain 13-86 4e-07 25.0 In-house 57-130 (133) alignment 
Range on Protein: 13-86
Range on HMM: 57-130/133.0
SMIDLVADVVRiQRKSGNGPITVHCSDGLGRTGTFCAMFTVL-ERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQY
. .. . .... . .. .. . |||  |. |..|.....    ..|.... .....  .    .. ||.  . .|
keleeavefie.kaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLley
PTPc_motif_SM00404 15-82 6.2e-07 24.4 In-house 66-133 (140) alignment 
Range on Protein: 15-82
Range on HMM: 66-133/140.0
IDLVADVVRIQrKSGNGPITVHCSDGLGRTGTFCAMFTVL-ERLKAEQVIDVFSTVKtLRIQRP-GFVND
.| |.|...   .. .| . |||  |. |..|.....    . |..........  .  .|..  .||. 
ldkvldfiena.ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR.piispnlnfvrq
subfamily_hpo-7_pd Subfamily hpo-7 2-103 7.5e-07 23.3 In-house 132-233 (263) alignment 
Range on Protein: 2-103
Range on HMM: 132-233/263.0
WPSTSSPNQATSMIdlvaDVVRIQRKSgnGPITVHCSDGLGRTGTFCAMFTVLE----RLKAEQ--VIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
|. .  |..| ...     .... |.|   .. |||| | ||.  |  . .|       |.  .   .|  | .. || .|.. ...  |  |     |.
Wiekndpelareil....nilkvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

FVNTFNNY
||   .  
fvlnnfak
subfamily_RNGTT_pd Subfamily RNGTT 8-86 2.3e-06 21.4 In-house 94-171 (189) alignment 
Range on Protein: 8-86
Range on HMM: 94-171/189.0
PNQATSMIDLVADVVRiqrKSGNGPITVHCSDGLGRTGTFCAMFTV-LERLKAEQVIDVFSTVKTLRIQRPGFVNDID-QY
..| ...| || . ..   |. .  |.|||  |  ||| . . . |  |  ..|. ...|.. .   | .  .....  .|
aeqvkefiklveeffk...knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrY
subfamily_egg_pd Subfamily egg 19-97 4.2e-06 20.6 In-house 191-270 (307) alignment 
Range on Protein: 19-97
Range on HMM: 191-270/307.0
ADVVRIQRKSGnGPITVHCSDGLGRTGTFCAMFTVLERLKAEQV--IDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
  |.|  |.    |. |.. .|  ...|. |. . |  |    .    |  .|. || .|.  |. . .| |...  | |.
lrvlrklrnls.kpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_DSP1_pd Subfamily DSP1 27-88 4.4e-06 20.9 In-house 92-154 (163) alignment 
Range on Protein: 27-88
Range on HMM: 92-154/163.0
KSGNGPITVHCSDGLGRTGTFCAMFTVL-ERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEF
|. || . .||  |. |  |.| .. .  .|.. |.  |    ....     |||... .|| 
kkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyek
subfamily_DSP14_pd Subfamily DSP14 13-89 7.2e-06 20.0 In-house 67-143 (157) alignment 
Range on Protein: 13-89
Range on HMM: 67-143/157.0
SMIDLVADVVRIQRKSgNGPITVHCSDGLGRTGTFCAMFTVleRLKAEQVIDVFSTVKTLRI-QRP--GFVNDIDQYEFI
.  | ||| ..  .|. .| . |||  |  |  ..| .. .  . .. .  . ...||. |   ||  || ... .||  
khfdevadkieevkkk.ggktlvhCvaGvSRSAslclaylm..kyeklsLreayklvksaRpiirPNvGFwkqlidyEkk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1-95 7.8e-06 19.7 In-house 180-277 (303) alignment 
Range on Protein: 1-95
Range on HMM: 180-277/303.0
NWPSTSSPNQ-ATSMIDLVADVVRIQRKSGNGPITVHCS-DGLGRTGTFCAMFTVLERLKAEQV-IDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
.|| .| |.. .  ..  . ..  . ||  ..  ||. |  | ||.|||. . |    |..||  .|.   ....|  |   |... |. ...    |
awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_ptpA1_pd Subfamily ptpA1 52-97 7.9e-06 19.8 In-house 353-398 (418) alignment 
Range on Protein: 52-97
Range on HMM: 353-398/418.0
TVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
..... ..   ...|| |  || ||||.|....|| | .|. |. .
aimdkynsridfnlfsivlklreqrpgmvqqleqylfcyktildei
subfamily_DSP15_pd Subfamily DSP15 15-90 8.4e-06 19.9 In-house 64-139 (151) alignment 
Range on Protein: 15-90
Range on HMM: 64-139/151.0
IDLVADVVRIQRKSGnGPITVHCSDGLGRTGTFCAMFTV-LERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIH
..   ...   |  . . . |||  |. |  | .... .    |. .....|  . ...     || . . .||  .
fkesvefihkcRlke.envlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektk