Gene AquePTP-Un-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP045_AA protein Get Run
AqueP045_AA_764-884 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 760-842 1.3e-25 85.1 In-house 3-85 (564) alignment 
Range on Protein: 760-842
Range on HMM: 3-85/564.0
KPIPRSAFSQHVKEMHREREKGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
|||| ... .||.... ...  || ||... ...  .   |. ..| .|||.||| ..| |||||| ..| ||||||||||||
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid
0051299 (Phosphotyrosine protein) phosphatases II 761-884 5.5e-25 83.8 In-house 4-171 (288) alignment 
Range on Protein: 761-884
Range on HMM: 4-171/288.0
PIPRSAFSQHVKEMHREREKGFELEYHSLASPKVYPH-FIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID-----------------
.|. . . ..|.....   .|.. |.. | | .. ..  .|.| .| .|||. .|.|.|.|||.||||||.|||||||||.||                 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

----------------------------RKCEFYFPEkiNETFEADGIHVKLNSITPYADFEEKKFIIEN
                            .||. |.|.  ... . . |.|.| |.. ..|.   .....|
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtn
0040438 (Phosphotyrosine protein) phosphatases II 766-884 3.6e-24 81.0 In-house 4-165 (317) alignment 
Range on Protein: 766-884
Range on HMM: 4-165/317.0
AFSQHVKEMHREREKGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID-----------------------
 . .... ...   .... |.. | | |...  .|.| .|..|||. .|.|.|.|||.||.|.|...|||||||..|                       
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

----------------------RKCEFYFPEkiNETFEADGIHVKLNSITPYADFEEKKFIIEN
                      .||. |.|.  .|| . ....|.| |.. .|...  .. .|.
rmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtleved
0045450 (Phosphotyrosine protein) phosphatases II 758-884 1.5e-22 76.1 In-house 5-187 (307) alignment 
Range on Protein: 758-884
Range on HMM: 5-187/307.0
RMKPIPRSAFSQHVKEMHREREKGFELEYHSLASPKVY---PHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGI-EGSDYINASFI------------
 ...|..  . ..|......   |.. |...| | .|.   .. ||.| .|..|||. .|.|.|..||.||.|||  |.|||||||..            
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

-----------------------------------------DRKCEFYFPEKiNETFEADGIHVKLNSITPYADFEEKKFIIEN
                                         ..||  |.|.. .|... . ..|.| |.. ....   .. ...
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtd
0043336 (Phosphotyrosine protein) phosphatases II 761-884 1.6e-22 75.7 In-house 1-166 (278) alignment 
Range on Protein: 761-884
Range on HMM: 1-166/278.0
PIPRSAFSQHVKEMHREREKGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID------------------
||... . ....|...   ....||...| | |...  ||.| .|..|||. .|.|.| |||.||.|.| ..|||||||..|                  
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

---------------------------RKCEFYFPekiNETFEADGIHVKLNSITPYADFEEKKFIIEN
                            ||  |.|   ..... ....|.| ... ..|.   .. ..|
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn
0050432 (Phosphotyrosine protein) phosphatases II 769-884 6.2e-21 70.5 In-house 33-190 (308) alignment 
Range on Protein: 769-884
Range on HMM: 33-190/308.0
QHVKEmhREREKGFELEYHSLASPKV-YPHFIAKLDCNGPKNRFANIYPFDDSRVVLsvldGiEGSDYINASFIDRK-----------------------
.....      ...| |.. | | |. .. ..|.| .|..|||. .|.|.| |||.|    . |||||||||..|                         
kllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFw

------------------------CEFYFPEKIN-ETFEADGIHVKLNSITPYADFEEKKFIIEN
                        |. |.|.... .. | ....|.| |.. ..|.   .....|
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltn
0046845 (Phosphotyrosine protein) phosphatases II 782-884 1.3e-20 69.4 In-house 2-157 (284) alignment 
Range on Protein: 782-884
Range on HMM: 2-157/284.0
FELEYHSLASPKVY---PHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDG-IEGSDYINASFIDR----------------------------------
.| |.. | | .|.   .  .|.| .|  |||. .|.|.|.|||.|..||| .|.|||||||..|                                   
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

----------------KCEFYFPEKiNETFEADGIHVKLNSITPYADFEEKKFIIEN
                ||..|.|.. .|... ....|.| |.. . |.   .. ..|
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltn
0039614 (Phosphotyrosine protein) phosphatases II 759-883 9.7e-20 66.6 In-house 11-177 (297) alignment 
Range on Protein: 759-883
Range on HMM: 11-177/297.0
MKPIPRSAFSQHVKEMHREREKGFELEYHSLASPKVyPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGI-EGSDYINASFID---------------
. ||| |.. .... ...    ...||. .| | |. .  ||.| .|..|||. .|.|.|.|||.|...||  ..|||||||..|               
sipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP

------------------------------RKCEFYFPEKINetfEADGIHVKLNSITPYADFEEKKFIIE
                              |||. |.||. .   . ....|.| ... ....   .. ..
lpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevt
0047943 (Phosphotyrosine protein) phosphatases II 781-884 3.2e-19 64.9 In-house 13-159 (273) alignment 
Range on Protein: 781-884
Range on HMM: 13-159/273.0
GFELEYHSLASPK-VYPHFIAKLDCNGPKNRFANIYPFDDSRVVLsvldGIEGSDYINASFIDR------------------------------------
....|.. | | | ...  .|.| .|. |||. .|.|.|.|||.|    | .||||||||..|                                     
llleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

---------KCEFYFPEKINE-TFEADGIHVKLNSITPYADFEEKKFIIEN
         ||. |.|.. .| . . . ..|.| |.. ..|.   .....|
telvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltn
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 762-842 6.9e-19 63.0 In-house 2-83 (318) alignment 
Range on Protein: 762-842
Range on HMM: 2-83/318.0
IPRSAFSQHVKEMHREREKGFELEYHSL-ASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
|. ... .||...... |  .. ||. |  |..   .. .  ..|  |||.||| ..|..|| |. |.| ||||||||..||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyid
0036941 (Phosphotyrosine protein) phosphatases II 786-884 1.2e-18 62.9 In-house 19-161 (297) alignment 
Range on Protein: 786-884
Range on HMM: 19-161/297.0
YHSLASPK-VYPHFIAKLDCNGPKNRFANIYPFDDSRVVLsvlDGiEGSDYINASFIDR-----------------------------------------
...| . .  ..  .|.| .| .|||. .|.|.|..||.|   |. |||||||||..|                                          
feellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelve

----KCEFYFPEKINETFEADGIHVKLNSITP--YADFEEKKFIIEN
    ||. |.|....|... ....|.| |..   ..|.   .. ...
lgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 761-842 1.4e-17 58.7 In-house 4-85 (319) alignment 
Range on Protein: 761-842
Range on HMM: 4-85/319.0
PIPRSAFSQHVKEMHREREKGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
.|.   . ...|...   |...| |.. |  ..      |. . | .|||. || ..| .||||| |||.||||||||||||
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid
0040439 (Phosphotyrosine protein) phosphatases II 796-883 2.2e-17 59.0 In-house 2-132 (249) alignment 
Range on Protein: 796-883
Range on HMM: 2-132/249.0
PHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID---------------------------------------------RKCEFYFP
.  .|.| .|..|||. .|.|.| |||.||.|.| ..|||||||.||                                              ||. |.|
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

EkiNETFEADGIHVKLNSITPYADFEEKKFIIE
.  ....| ....|.| |.. ..|.   .. ..
l..ggsleygdftvtllsvevkddytvrtlelt
subfamily_PTPRB_pd Subfamily PTPRB 758-842 3.4e-17 57.4 In-house 3-88 (293) alignment 
Range on Protein: 758-842
Range on HMM: 3-88/293.0
RMKPIPRSAFSQHVKEMHREREKGFELEYHSLASP-KVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
. |||  . |..|||.|... . .|  ||..| .  |   . .|.| .|  |||. || |.| ||| |. |.. .|||||||..|.
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyip
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 759-843 8.8e-17 55.1 In-house 2-83 (95) alignment 
Range on Protein: 759-843
Range on HMM: 2-83/95.0
MKPIPRSAFSQHVKEMHREREKGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVldgIEGSDYINASFIDR
.|||  | |  || ||| . .. |. |..|..     |. .   ..| ||||| ||.|.| .||||.       |||||| |.| 
fkpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdg
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 760-842 3.7e-16 53.5 In-house 2-82 (392) alignment 
Range on Protein: 760-842
Range on HMM: 2-82/392.0
KPIPRSAFSQHVKEMhRErEKGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
.||| . |   |..  |     |  |.| | .|..||. .|. . | .|||. || |.| .||.| |.| |  |||.|||.|.
qpipvaqfpafvekn.rh.salffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyip
0042113 (Phosphotyrosine protein) phosphatases II 800-883 1.2e-15 53.1 In-house 4-130 (245) alignment 
Range on Protein: 800-883
Range on HMM: 4-130/245.0
AKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID---------------------------------------------RKCEFYFPEkiN
|.| .|..|||. .|.|.|..||.||. .| ..|||||||..|                                              ||. |.|.  .
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

ETFEADGIHVKLNSITPYADFEEKKFIIE
|... ....|.| |.. ..|.   .. ..
esltygdftvtllseehlddytvrtlevt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 769-844 3.9e-15 50.7 In-house 10-86 (288) alignment 
Range on Protein: 769-844
Range on HMM: 10-86/288.0
QHVKEMHREREKGFELEYHSL-ASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFIDRK
..|...... ..||. ||.|| |  |   . ...|  | .|||. || |.|  || |  |.  .|.||||||.|| .
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge
subfamily_PTPRG_pd Subfamily PTPRG 762-842 5.1e-15 49.7 In-house 1-85 (563) alignment 
Range on Protein: 762-842
Range on HMM: 1-85/563.0
IPRSAFSQHVKEMHREREKGFELEYHSL---ASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGS-DYINASFID
.| . |..|| ..| . ..||. |...|     .|  .   ..  .|  |||  || ..| ||| || | |.... |||||..||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 762-842 7.5e-15 49.0 In-house 2-80 (515) alignment 
Range on Protein: 762-842
Range on HMM: 2-80/515.0
IPRSAFSQHVKEmhREREKGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
.| . |   |.     .   |  |.| |  |..||  .|. . | .|||. || |.| .|| | |..    |||.|||.| 
lplaqfPafvnk..nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyip
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 761-842 1.8e-14 48.3 In-house 2-81 (315) alignment 
Range on Protein: 761-842
Range on HMM: 2-81/315.0
PIPRSAFSQHVKEMHreREKGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
||| . |   |.. .  .   |  |.| |  |..|.. .|. . | .|||. || |.| .||.| |.| .  |||||||.| 
pipvaqfpafvnknr..htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyik
subfamily_PTPRA_pd Subfamily PTPRA 758-842 2.2e-14 48.1 In-house 10-95 (330) alignment 
Range on Protein: 758-842
Range on HMM: 10-95/330.0
RMKPIPRSAFSQHVKEMHREREKGFELEYHSLASPKVYPHF-IAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
.  |.|   . . ..    .  | |  |. .| . ..   . .|. . |  |||. || |.| |||.|||..|.| ||||||||||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid
0045098 (Phosphotyrosine protein) phosphatases II 790-884 2.4e-14 48.9 In-house 18-143 (278) alignment 
Range on Protein: 790-884
Range on HMM: 18-143/278.0
ASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVlsvldgiegsDYINASFID-------------------------------------------RKCE
. . ..  . | . .|..|||. .|.|.| |||.          ||||||.||                                            ||.
llgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

FYFPEkiNETFEADGIHVKLNSITPYADFEEKKFIIEN
 |.||  ..... ....|.| |.. . |.   .....|
qywpe..ggsltygdftvtllseevlddytlrtllvtn
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 760-843 6e-14 47.0 In-house 7-94 (298) alignment 
Range on Protein: 760-843
Range on HMM: 7-94/298.0
KPIPRSAFSQHVKEMHREREKGFELEYHSLASPKV----YPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFIDR
... . |... .. .....  |..||.. | | .       . .|. . |  |||.|.| ..| |||||.  |. | ||||||||.. 
aedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflha
subfamily_Ptp69D_pd Subfamily Ptp69D 761-842 6e-14 46.9 In-house 3-85 (307) alignment 
Range on Protein: 761-842
Range on HMM: 3-85/307.0
PIPRSAFSQHVKEMHREREKGFELEYHSLASPKV-YPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
.|..   .. .|  .|. . |.. ||..| . ..     ... . |  |||. .| .||. ||.|... | | ||||||||| 
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 759-842 1.6e-13 45.7 In-house 13-98 (319) alignment 
Range on Protein: 759-842
Range on HMM: 13-98/319.0
MKPIPRSAFSQHVKEMHREREKGFELEYHSLAS--PKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
....|     . .|.   .  . .| |.. ..   ..      | || |  |||. || .|| ..| |  |.|.|.||||||||..
vpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 759-843 2.6e-13 44.8 In-house 7-89 (297) alignment 
Range on Protein: 759-843
Range on HMM: 7-89/297.0
MKPIPRSAFSQHVKEMHRerEKGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFIDR
 .||| | |.  |.. ..   . |. |.. | . ...|   |.   | .|.|..|| |.| ||| | ...    |||.||||.  
rrpiplsdfatlvqknrh..tdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 760-842 4.5e-13 43.8 In-house 4-86 (315) alignment 
Range on Protein: 760-842
Range on HMM: 4-86/315.0
KPIPRSAFSQHVKEMHREREKGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
.|||   .  .| . .   ..||. .| |.   ...|  .||   |  |||. || ..| ||| | .|.  ..|||.||.|||
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfid
subfamily_PTPN6_pd Subfamily PTPN6 772-844 2.5e-12 41.4 In-house 18-92 (306) alignment 
Range on Protein: 772-844
Range on HMM: 18-92/306.0
KEMHREREKGFELEYHSL---ASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSvLDGIEGSDYINASFIDRK
|| ..   .||| |...|   .. |.. .  ..   |  |||. || |||..||.|.  ... |||||||..|...
keeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikke
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 760-842 2.8e-12 41.4 In-house 2-83 (305) alignment 
Range on Protein: 760-842
Range on HMM: 2-83/305.0
KPIPRSAFSQHVKEMHREREKGFELEYHSLASPkVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
|.|  . .....||.. . .||.| .|.||..    . .. | . |  |||...| ..||.|. |.  .  . |||||||..|
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 800-842 3.8e-12 41.3 In-house 20-62 (284) alignment 
Range on Protein: 800-842
Range on HMM: 20-62/284.0
AKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
| || |  |||. .| .|| ..| |  |.|.|.||||||||| 
anldqnkdknrighilafdknvvklerliGeefsdyinasfit
0037934 (Phosphotyrosine protein) phosphatases II 798-884 1e-11 40.3 In-house 3-125 (243) alignment 
Range on Protein: 798-884
Range on HMM: 3-125/243.0
FIAKLDCNGPKNRFANIYPFDDSRVVLsvldgiEGSDYINASFI----------------------------------------------DRKCEFYFPe
.||.| .| .|||. .|.|.|.|||.|      ||||||||..|                                                ||. |.| 
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

kiNETfEADGIHVKLNSITPYADFEEKKFIIEN
  .|. . ....|.| |.. ..|.   .. .||
..gev.tygdftvtllseehlddytvrtlllen
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 760-842 1.1e-11 38.8 In-house 4-84 (440) alignment 
Range on Protein: 760-842
Range on HMM: 4-84/440.0
KPIPRSAFSQHVKEMHRERekGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
.||  . |...|.. .| |   || |.  | |  . |  || |  |  |||. ||  .| |||.|  . |.  |||||||.|.
rpiivadfadyvqnnrrsr..afedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_PTPRK_pd Subfamily PTPRK 768-843 1.7e-11 38.5 In-house 10-81 (314) alignment 
Range on Protein: 768-843
Range on HMM: 10-81/314.0
SQHVKEMHREREKGFELEYHSLASPkvypHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFIDR
 |... ..|    ||  || ||          || | |  |||. .| ..| |||.| ..||   ||||||..|| 
lqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalids
subfamily_PTPN9_pd Subfamily PTPN9 767-842 3.6e-11 37.6 In-house 6-79 (297) alignment 
Range on Protein: 767-842
Range on HMM: 6-79/297.0
FSQHVKEMhreREKGFELEYHSLASPKVYPHF-IAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
. ..|||.   ...|   ||  . . .|   |  .|| .|  |||....  .|..||||. .|. | ||||||.|.|
lvayvkek...gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvd
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 768-843 4.6e-11 37.4 In-house 3-79 (281) alignment 
Range on Protein: 768-843
Range on HMM: 3-79/281.0
SQHVKEMHREREKGFELEYHSLAS-PKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFIDR
 .|.|..... ..||  ||..||.     .   .| | |  |||. ||  .| .||...  .  . .|||||.|.. 
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpg
zf-B_box B-box zinc finger 103-141 7.3e-11 30.3 Pfam-A 2-41 (42) alignment 
Range on Protein: 103-141
Range on HMM: 2-41/42.0
QEATCSDHGKP-LEFFCERCNTVICSHCPFRNHKHHEYDL
.| .|..|..  |..||| |.. .|  | .  || |... 
eerkCpeHeekelqlfCedCqqllCedClleeHkgHtvvp
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 768-842 1.4e-10 35.9 In-house 11-85 (325) alignment 
Range on Protein: 768-842
Range on HMM: 11-85/325.0
SQHVKEMHREREKGFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
 .||.. . . . ||  |.  | |     . .| .  |  |||| |. ..| |||||  ..    |||||||.. 
vehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylr
zf-RING_2 Ring finger domain 18-63 1.8e-10 29.3 Pfam-A 2-44 (44) alignment 
Range on Protein: 18-63
Range on HMM: 2-44/44.0
TCPVCLEHY---TNPKILPCHHSFCQHCLEGLpLDKKNetyylSCPTCR
.|..||. .   ...  |||.| |...||. . | ..|     |||.||
eCaiCldelsegeevvrlpCgHvFHeeCldew.lrssn.....sCPlCr
zf-C3HC4_4 zinc finger of C3HC4-type, RING 19-62 2e-10 28.9 Pfam-A 1-42 (42) alignment 
Range on Protein: 19-62
Range on HMM: 1-42/42.0
CPVCLEHYTNPKILPCHHSFCQHCLEGLPLDKKNETyyLSCPTC
||.||.  ..|  | | ||||..|.. |  ....|   |.|| |
CPiCldyLekPvsleCGhsfClsCinslqkepdgeq..llCplC
subfamily_PTPN12_pd Subfamily PTPN12 791-843 2.2e-10 34.9 In-house 26-78 (290) alignment 
Range on Protein: 791-843
Range on HMM: 26-78/290.0
SPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFIDR
. |||.   .. . |  |||. .| |.| |||.||  .. ||||||||.||  
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg
zf-C3HC4 Zinc finger, C3HC4 type (RING finger) 19-62 2.4e-10 26.5 Pfam-A 1-41 (41) alignment 
Range on Protein: 19-62
Range on HMM: 1-41/41.0
CPVCLEHYTNPK-ILPCHHSFCQHCLEGLPLDkkN--ETyylsCPTC
||.||| ...|. .|.|.||||..|.. .  .  .  ..    ||.|
CpiCleeakepnelleCkHsfCskCirkilks..rkkvk....CPlC
zf-RING_UBOX RING-type zinc-finger 19-60 2.4e-10 26.6 Pfam-A 1-43 (43) alignment 
Range on Protein: 19-60
Range on HMM: 1-43/43.0
CPVCLEhYTN----PKILPCHHSFCQHCLEGLPLDKK-NetyYLSCP
||.. |  |.    |..||| | .....||.|  ... |    . ||
CPIske.qtteqnpPvvLpCGHvisrdaleklskkgran...rfkCP
NHL NHL repeat 582-605 8.1e-10 24.9 Pfam-A 5-28 (28) alignment 
Range on Protein: 582-605
Range on HMM: 5-28/28.0
HDIAIDSQGLAYVADTFNHRILKF
|..|.||.|  ||||. |||. .|
hGvavdsdGdvyVaDsnnhrvqvf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 800-843 9.1e-10 33.2 In-house 4-47 (250) alignment 
Range on Protein: 800-843
Range on HMM: 4-47/250.0
AKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFIDR
||   |  |||.|.| ..| |||||   .| . ||||||||.. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhg
zf-C3HC4_2 Zinc finger, C3HC4 type (RING finger) 19-62 1e-09 26.8 Pfam-A 1-39 (39) alignment 
Range on Protein: 19-62
Range on HMM: 1-39/39.0
CPVCLEHYTNP-KILPCHHSFCQHCLEGLpLDKKnetyyLSCPTC
||.||| ...| ..||| |.||. |.| | | |.      .||.|
CpiCleelrdpvvllpCgHlfCkeCiekl.leke.....kkCPiC
DSPc_SM00195 800-842 1.4e-09 33.0 In-house 21-63 (263) alignment 
Range on Protein: 800-842
Range on HMM: 21-63/263.0
AKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
|. . |  |||. ||.|.|..|| |.  .. ||||||||..|.
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyik
PTPc_SM00194 800-842 1.4e-09 33.0 In-house 21-63 (263) alignment 
Range on Protein: 800-842
Range on HMM: 21-63/263.0
AKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
|. . |  |||. ||.|.|..|| |.  .. ||||||||..|.
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyik
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 762-843 2.9e-09 31.2 In-house 2-86 (290) alignment 
Range on Protein: 762-843
Range on HMM: 2-86/290.0
IPRSAFSQHVKEMHREREKGFELEYHSLASPKV-YPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEG--SDYINASFIDR
|| . |...| . | . ..||. ....| | .  .   ..    | ..|||||| . || |..|  . | .    .||||..|. 
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 762-843 5.4e-09 30.5 In-house 2-81 (287) alignment 
Range on Protein: 762-843
Range on HMM: 2-81/287.0
IPRSAFSQHVKEMHREREKGFELEYHSLASPKVYPHFIAK--LDCNGPKNRFANIYPFDDSRVVLSvldgIEGSDYINASFIDR
|| . |.. |.. |.. ..||.  .  | . .  .. .       | .|||...| . |. ||.|      |  |||||.||| 
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidg
NHL NHL repeat 440-464 9.5e-09 21.6 Pfam-A 3-27 (28) alignment 
Range on Protein: 440-464
Range on HMM: 3-27/28.0
VPYGIAVSDDNHVIVTECNGHCVTI
 | |.||..|..|.|...| |.| .
nPhGvavdsdGdvyVaDsnnhrvqv
zf-RING_5 zinc-RING finger domain 19-64 1.1e-08 24.2 Pfam-A 2-44 (44) alignment 
Range on Protein: 19-64
Range on HMM: 2-44/44.0
CPVCLEHY---TNPKILPCHHSFCQHCLEGLPldkkneTYYLSCPTCRH
|..|....    .. ...|.|.||. ||. |       . . .||.||.
CnkCfkklseeekfyltsCgHifCekClknlk......akekkCpvCrk
zf-C3HC4_3 Zinc finger, C3HC4 type (RING finger) 16-64 1.3e-08 20.9 Pfam-A 2-45 (50) alignment 
Range on Protein: 16-64
Range on HMM: 2-45/50.0
QLTCPVCLEHYTNPKILPCHHS-FCQHCLEGLPLdkknetYYLSCPTCRH
. .|.||||. ..  .||| |  .|. | | |           .||.|| 
kklCvvClereadvvllpCgHlclCeeCaerllk......rkkkCpiCrs
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 764-842 1.5e-08 28.6 In-house 4-85 (439) alignment 
Range on Protein: 764-842
Range on HMM: 4-85/439.0
RSAFSQHVKEMHREREKGFELEYHSLASPKVYPHFIAKL---DCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
|. | .||......... |. ..... | .   . || |   . ...|||. .. .|| .||.|  . |.  | |||| .|.
rdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyik
0049772 (Phosphotyrosine protein) phosphatases II 795-847 1.9e-08 29.9 In-house 36-86 (314) alignment 
Range on Protein: 795-847
Range on HMM: 36-86/314.0
YPHFIAKLDCNGPKNRFANIYPFDdSRVVLSVLDgIEGSDYINASFIDRKCEF
. . .|.| .|  |||. .|.|.| .||.|. |. ..||||||||..|  . |
ltilvadlflnrdknryldilpad.nrvilpglp.vsgsdyinasyvdgflkf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 800-848 2.8e-08 27.7 In-house 34-81 (244) alignment 
Range on Protein: 800-848
Range on HMM: 34-81/244.0
AKLDCNGPKNRFANIYPFDDSRVVLSVLDgIEGSDYINASFIDRKCEFY
| | .|  |||. || |||..||.||     ||||||||..|.   .  
avlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsqnii
subfamily_ptpA1_pd Subfamily ptpA1 766-843 1e-07 26.0 In-house 12-85 (418) alignment 
Range on Protein: 766-843
Range on HMM: 12-85/418.0
AFSQHVKEMHREREKgFELEYHSLASPKVYpHfiAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFIDR
 . .|.| .|. .|. | |   |.   .           |  |||..|| | . .|| |  ..  |||||||| .|| 
nlknhikcihkikee.frlleesvgpsets.e..gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 805-842 3.4e-07 24.3 In-house 38-74 (287) alignment 
Range on Protein: 805-842
Range on HMM: 38-74/287.0
NGPKNRFANIYPFDDSRVVLSvLDGIEGSDYINASFID
.  |||.|.. |.||.||.||  .|  ||||||| .. 
avkknryadvlPiddtrvlls.aegelGsdyinanyva
NHL NHL repeat 531-559 3.8e-07 16.5 Pfam-A 1-28 (28) alignment 
Range on Protein: 531-559
Range on HMM: 1-28/28.0
FNVPFGIAISpITGQVYVADKFNYRIQVL
.| | |.|..  .|.|||||  | |.||.
lnnPhGvavd.sdGdvyVaDsnnhrvqvf
NHL NHL repeat 628-654 3.9e-07 16.5 Pfam-A 4-28 (28) alignment 
Range on Protein: 628-654
Range on HMM: 4-28/28.0
PIGMTIDtgVTGLVYVSDWGNNRISVF
| | ..|   .| |||.| .|.|. ||
PhGvavd..sdGdvyVaDsnnhrvqvf
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 800-841 4.2e-07 24.4 In-house 3-44 (239) alignment 
Range on Protein: 800-841
Range on HMM: 3-44/239.0
AKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFI
||   |  |||.|||  .| |||||  |     |||||||..
akkrvnkaknryanivtydhsrvvleklsndphsdyinasyl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 800-841 4.2e-07 24.4 In-house 2-43 (239) alignment 
Range on Protein: 800-841
Range on HMM: 2-43/239.0
AKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFI
||   |  |||.|||  .| |||||  |     |||||||..
akkrvnkaknryanivtydhsrvvleklsndphsdyinasyl
subfamily_CG7180_pd Subfamily CG7180 805-842 4.8e-07 23.7 In-house 42-79 (296) alignment 
Range on Protein: 805-842
Range on HMM: 42-79/296.0
NGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
|  |||  .. |.|  ||||. ||| | ||||||...|
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvd
SGL SMP-30/Gluconolaconase/LRE-like region 531-614 5.3e-07 15.6 Pfam-A 133-219 (246) alignment 
Range on Protein: 531-614
Range on HMM: 133-219/246.0
FNVPFGIAISPITGQVYVADKFNYRIQVLNPDLTfSHSIDNKGSASELFMSHD----IAIDSQGLAYVADTFNHRILKFSPDGNFVGQ
.... |||.|| . ..|.||  . .|.. . | . .  ..|.    .|   .     .|.|..|  .||   ........|||. ...
ltisNGiawspdgktlYlaDsltrkiwafdvdae.ggelsnrrvfidlkkgegepDGlavDaeGnvwvAvwgggkvvridpdGkllee
NHL NHL repeat 486-510 8.9e-07 15.4 Pfam-A 1-27 (28) alignment 
Range on Protein: 486-510
Range on HMM: 1-27/28.0
FSSPRGVAITPDKFIFVSD--NHRIQK
...| |||. .|  ..|.|  |||.|.
lnnPhGvavdsdGdvyVaDsnnhrvqv
subfamily_PTPRN_pd Subfamily PTPRN 783-842 1.2e-06 22.4 In-house 32-93 (297) alignment 
Range on Protein: 783-842
Range on HMM: 32-93/297.0
ELEYHSLASPKVYPH--FIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGIEGSDYINASFID
| |...|.. .  |.   .|| . |  ||| ... |.|.||| |.     | |||||||.| 
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasail
subfamily_PTPN1_pd Subfamily PTPN1 793-842 1.6e-06 22.0 In-house 20-65 (290) alignment 
Range on Protein: 793-842
Range on HMM: 20-65/290.0
KVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDGiegsDYINASFID
. .|.  |||. | ..||. .. |.| ||..|   |     ||||||...
sdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslve
Y_phosphatase Protein-tyrosine phosphatase 806-842 2.4e-06 22.5 Pfam-A 2-36 (235) alignment 
Range on Protein: 806-842
Range on HMM: 2-36/235.0
GPKNRFANIYPFDDSRVVLsvlDGIEG-SDYINASFID
  |||. .| |.|..|| |   .| || ||||||....
kkknRykdilpydktrvkl...kgsegpsdYInAnyvk
Y_phosphatase Protein-tyrosine phosphatase 806-842 2.4e-06 22.5 In-house 2-36 (235) alignment 
Range on Protein: 806-842
Range on HMM: 2-36/235.0
GPKNRFANIYPFDDSRVVLsvlDGIEG-SDYINASFID
  |||. .| |.|..|| |   .| || ||||||....
kkknRykdilpydktrvkl...kgsegpsdYInAnyvk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 772-843 4.3e-06 20.6 In-house 10-80 (301) alignment 
Range on Protein: 772-843
Range on HMM: 10-80/301.0
KEMHRERekgFELEYHSLASPKVYPHFIAKLDCNGPKNRFANIYPFDDSRVVLSVLDG--IEGSDYINASFIDR
  .| ..   || .|..| . .  .  .   . | . ||| || ..|| |..|.      .   .|||||.|| 
aakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidg
subfamily_PTPN3_pd Subfamily PTPN3 799-842 7e-06 20.2 In-house 35-74 (280) alignment 
Range on Protein: 799-842
Range on HMM: 35-74/280.0
IAKLDCNGPKNRFANIYPFDDSRVVLSvldGIEGsDYINASFID
.|..  | .|||. .| |.|. || |.     |  |||||....
aarkpenlsknryrdilpydatrvklk...eset.dyinanyvn
Big_3_4 Bacterial Ig-like domain (group 3) 379-410 7.7e-06 13.7 Pfam-A 3-34 (54) alignment 
Range on Protein: 379-410
Range on HMM: 3-34/54.0
TVTTTSTDPGVYRIQCNPSTHGTHTVKVQVYD
|.||| .. | . ...  .. ||.||.| ..|
tytttadadGtWsvtvpaladGtytvtvtatD
subfamily_PTPN23_pd Subfamily PTPN23 799-842 8.8e-06 19.7 In-house 37-76 (288) alignment 
Range on Protein: 799-842
Range on HMM: 37-76/288.0
IAKLDCNGPKNRFANIYPFDDSRVVLSvldgIEGSDYINASFID
||   ..  |||. .| |.| .||.|      .  |||||||. 
iaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvk