Gene AquePTP-Un-5 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP047_AA protein Get Run
AqueP047_AA_281-485 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 282-485 1.6e-58 193.8 In-house 36-240 (308) alignment 
Range on Protein: 282-485
Range on HMM: 36-240/308.0
EDNAKESIIGKEYKDIPMLLQDMS---IWPPDTYSKNRYRNVIPNKNTAVTLsgeSIADRYINANFIDGYN-GMEKAYICAQAPIYDTIPDFWRMIWECN
|.    ... .|.......  ...    . |.  .||||....|. .. | |   .  . ||||...|||. . ....|..|.| ..|. |||||.|| |
ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

VNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTG
|...|||. ..| |..|||.|||.   .....||.|||..  ||||. |.| .| .. ..|. .| |. | . .|||.|||... ..|.| |.|   . |
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg

GPLLVHCR
|| .|||.
gpivVHCs
0046845 (Phosphotyrosine protein) phosphatases II 293-485 2.2e-56 186.7 In-house 5-212 (284) alignment 
Range on Protein: 293-485
Range on HMM: 5-212/284.0
EYKDIPMLLQDM-----SIWPPDTYSKNRYRNVIPNKNTAVTLSGESIA---DRYINANFIDGYN----GMEKAYICAQAPIYDTIPDFWRMIWECNVNT
|.. ...|  ..         |  .|||||....|. .. | |. ..     . ||||...|||.      .|..|..|.|  .|. |||||.|| ||..
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

VVMLCGIFEGGKNKCAKYWPPPdtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINS-DEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT---
.|||....| |..|||.|||.   ... .||.|||..  ||| . |.|  |... .. .. .| |. | . .|||.|||... ..||| ..|   ..   
IVmltelvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

-GGPLLVHCR
 ||| .|||.
gggpivVHCs
0051299 (Phosphotyrosine protein) phosphatases II 288-485 3.5e-56 186.1 In-house 23-227 (288) alignment 
Range on Protein: 288-485
Range on HMM: 23-227/288.0
SIIGKEYKDIPMLLQDMS---IWPPDTYSKNRYRNVIPNKNTAVTLSGES--IADRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVV
... .|..... || |..      |  ..||||....|. .. | || ..    . ||||..|||||   | .|..|.|  .|. |||||.|| ||...|
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIv

MLCGIFEGGKNKCAKYWPPpdtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSIN----SDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HT
||....| |..|||.|||.   .....||..||..  ||||. |.| .| |. .     |. .| |. | . .|||.|||. . ..|.| ..|     ..
mltklvelgrekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasg

GGPLLVHCR
||| .|||.
ggpvvVHCs
0047943 (Phosphotyrosine protein) phosphatases II 284-485 4.1e-55 182.5 In-house 8-213 (273) alignment 
Range on Protein: 284-485
Range on HMM: 8-213/273.0
NAKESIIGKEYKDIPMLLQDMS---IWPPDTYSKNRYRNVIPNKNTAVTLsgESIADRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNT
    ... .|..... |  ...      |.  .||||....|. .. | |  ..  . ||||...||||   | .|..|.| ..|. |||||.|| ||..
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrv

VVMLCGIFEGGKNKCAKYWPPPDTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH----T
.|||. ..| |..|||.|||.   . ...||.|||..  ||. . |.|  | .. .... .| |. | . ||||.|||..  ..||| |.|   .     
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

GGPLLVHCR
.|| .|||.
ngpvvVHCs
0036941 (Phosphotyrosine protein) phosphatases II 288-485 1.3e-53 177.6 In-house 13-215 (297) alignment 
Range on Protein: 288-485
Range on HMM: 13-215/297.0
SIIGKEYKDIPMLLQDMS---IWPPDTYSKNRYRNVIPNKNTAVTLsgESIADRYINANFIDGYnGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVML
... ||..... || ..|      |.. .||||....|. .| | |  ..  . ||||...||| . ....|..|.|  .|. |||||.|| ||...|||
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

CGIFEGGKNKCAKYWPPPdTNDTEYYGPFTVRNNYEEV--LPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH----TGG
.  .| |..|||.|||.  .... .||.|||..  .||  |. |.. .| |. . .. .| |. | . ||||.|||| . ..|.| |.|   .     ||
telvelgrekcaqywple.egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

PLLVHCR
| ||||.
pvlVHCs
0040438 (Phosphotyrosine protein) phosphatases II 309-485 1.1e-52 174.7 In-house 41-217 (317) alignment 
Range on Protein: 309-485
Range on HMM: 41-217/317.0
PDTYSKNRYRNVIPNKNTAVTLSGESI--ADRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtND
|.  .||||....|. .. | || ..    . ||||...||.|   | .|..|.|  .|. |||||.|| .|...|||.  .| |..|||.|||    ..
penkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl...ge

TEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVHCR
| .||.|||..  ||.|. ...  | |. . |. .| |. | . ||||.|||.   ..|.| |||  .  . |||.|||| 
tltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCs
subfamily_PTPRD_pd Subfamily PTPRD 291-484 7.8e-52 171.7 In-house 26-221 (564) alignment 
Range on Protein: 291-484
Range on HMM: 26-221/564.0
GKEYKDIPMLlQDMSIW---PPDTYSKNRYRNVIPNKNTAVTLSGESIA--DRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLC
 .|||.| .  | ...     |   .|||| |...  .. | ||         ||||.|||||.  .|||| .|.|. .|| |||||.|| |..|.||| 
eeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmlt

GIFEGGKNKCAKYWPPPdtNdTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVH
 . | ||.||.||||    . || || .||  . || |  | .  .... ....  | |  | |  ||| ||||.| ..|.. . |.    .. ||..||
kleEkgkvkchkYWPek..g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVh

C
|
C
0039614 (Phosphotyrosine protein) phosphatases II 289-485 1.1e-51 171.4 In-house 33-230 (297) alignment 
Range on Protein: 289-485
Range on HMM: 33-230/297.0
IIGKEYKDIPMLLQDMSI-WPPDTYSKNRYRNVIPNKNTAVTLSGES---IADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVML
.. .|..... |  |.||   |   .||||....|. .. | |..|      . ||||...|||. . ...|..|.|  .|. |||||.|| .|...|||
llllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmL

CGIFEGGKnKCAKYWPPPDTndteYYGPFTVRNNYEEVLPFYKVVYLSVSInsDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH----TGGPL
.  .| |. |||.|||.  .    .||.|||..  .|.|. |.| .|.|.   .. .| |. | . ||||.|||. .  .||| |.|   .     ||| 
tklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpv

LVHCR
|||| 
lVHCs
0045450 (Phosphotyrosine protein) phosphatases II 307-485 3e-51 170.4 In-house 51-242 (307) alignment 
Range on Protein: 307-485
Range on HMM: 51-242/307.0
WPPDTYSKNRYRNVIPNKNTAVTLSGESIA---DRYINANFI--------DGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKC
  |   .||||....|. .| | || ..     . ||||...        |||.   ...|..|.|  .|. |||||.|| .|...|||.. .| |..||
llpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekc

AKYWPPPdtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSIN-SDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI----NHTGGPLLVHCR
|.|||    ... .||.|||..  ||.|. |.| .| |. .  .. .| |. |.. ||||.|||.   ..|.| |.|      .  ||| ||||.
aqywPde..geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs
0043336 (Phosphotyrosine protein) phosphatases II 307-485 3.3e-51 169.8 In-house 41-218 (278) alignment 
Range on Protein: 307-485
Range on HMM: 41-218/278.0
WPPDTYSKNRYRNVIPNKNTAVTLSGESIA--DRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdt
. |. ..||||....|. .. | || ..    . ||||...||||  .| .|..|.|  .|. |||||.|| .|.|.|||.. .| |..|||.|||    
llpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp....

NDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVHCR
.....||.|||..  ||.|. |.|  | |. . |  .| |. . . ||||.||||.  ..|.| .||     . .||.||||.
ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCs
0045098 (Phosphotyrosine protein) phosphatases II 310-485 7.9e-50 165.2 In-house 32-214 (278) alignment 
Range on Protein: 310-485
Range on HMM: 32-214/278.0
DTYSKNRYRNVIPNKNTAVTlsgesiaDrYINANFIDGYngmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtNDTEY
. ..||||....|. .. |        | ||||..||||    |..|..|.|  .|. |||||.|| .....|||.. .|.|..|||.|||.   .....
gnldknRykdilpydhsrVk.......d.YINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe...ggslt

YGPFTVRNNYEEVLPFYKVVYLSVSIN----SDEAERDVMLFIFQGWPDFGVPEQA--GPILEFQEAVTIN---------------HTGGPLLVHCR
||.|||..  ||||. | .. | |       .|  .| |  . . .|||.|||..    ..||. | .                    ||| ||||.
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCs
0040439 (Phosphotyrosine protein) phosphatases II 311-485 8.1e-48 158.5 In-house 11-187 (249) alignment 
Range on Protein: 311-485
Range on HMM: 11-187/249.0
TYSKNRYRNVIPNKNTAVTLSG--ESIADRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtNDTE
  .||||....|. .. | ||   .   . ||||..||||.   . .|..|.|  .|..|||||.|| .....|||.  .| |..|||.|||.   ... 
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...ggsl

YYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH----TGGPLLVHCR
.|| |||..  .||.. |.| .| .. . |  .| |. . . .|||.|||.   ..|.| |||   .    .|||.|||| 
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCs
0042113 (Phosphotyrosine protein) phosphatases II 312-485 9e-48 158.2 In-house 10-184 (245) alignment 
Range on Protein: 312-485
Range on HMM: 10-184/245.0
YSKNRYRNVIPNKNTAVTLSGESIA--DRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtNDTEY
 .||||....|. .| | || ..    . ||||...|||.  .| .|..|.|  .|..|||||.|| ...|.|||.  .| |..|||.|||.   ... .
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...geslt

YGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI---NHTGGPLLVHCR
|| |||..  ||.|. |.| .|.|. . |  .| |. . . .|||.|||.    .|.| |.|     .. .||.||||.
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCs
DSPc_SM00195 302-485 1.6e-47 157.4 In-house 27-203 (263) alignment 
Range on Protein: 302-485
Range on HMM: 27-203/263.0
QdmsiwppdtySKNRYRNVIPNKNTAVTLSGES--IADRYINANFIDGYnGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYW
.          |||||.|..|...| | |. |     . |||||.|.|.   .|.||..|.|  .|. |||||.|| .|...|||.  .| ||.||..||
k..........sknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PPPDtNDTEYYGPFTVRNNYEEVLP-FYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT--GGPLLVHCR
|    ...| .| ..| .  .|  .  ...  |... . .| .|.|  . ...||| |||... ..||. .||.  .    ||..||| 
pees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs
PTPc_SM00194 302-485 1.6e-47 157.4 In-house 27-203 (263) alignment 
Range on Protein: 302-485
Range on HMM: 27-203/263.0
QdmsiwppdtySKNRYRNVIPNKNTAVTLSGES--IADRYINANFIDGYnGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYW
.          |||||.|..|...| | |. |     . |||||.|.|.   .|.||..|.|  .|. |||||.|| .|...|||.  .| ||.||..||
k..........sknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PPPDtNDTEYYGPFTVRNNYEEVLP-FYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT--GGPLLVHCR
|    ...| .| ..| .  .|  .  ...  |... . .| .|.|  . ...||| |||... ..||. .||.  .    ||..||| 
pees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 289-485 3.3e-47 156.1 In-house 23-224 (305) alignment 
Range on Protein: 289-485
Range on HMM: 23-224/305.0
IIGKEYKDIPMLLQDMSIWPPD-TYSKNRYRNVIPNKNTAVTLSGESIAD--RYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLC
 . ..|| .... . . .   .   .|||...... ..  . |. ..  |   ||||...|||.. .|.|| ||.|. .|. ||||.|.|. |.|.|||.
gleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykr.kkkyivaqgPlkntvadfWrliveekvstivmlt

GIFEGGKNKCAKYWPPPDTNDTEYyGPFTVRNNYEEVLPFYKVVYLSVSI-NSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTGG---PLL
.. ||||.|| .|||   |...|. |.|.|  . |.  . |    |..|| ..|. .| |. . .  ||| |||..|. .|.. . |. ..  .   |||
klveggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpll

VHCR
||| 
VhCs
Y_phosphatase Protein-tyrosine phosphatase 313-485 3.6e-47 156.1 Pfam-A 3-178 (235) alignment 
Range on Protein: 313-485
Range on HMM: 3-178/235.0
SKNRYRNVIPNKNTAVTLSGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPpPDTNDTEYYGP
.||||....|  .| | |.|.. .  |||||...||.  .|..|..|.|. .|| |||||.|. .|...|||.   | |..|||.|||  .......|| 
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.eeeeesltygd

FTVRNN-YEE-VLPFYKVVYLSVSINSDE-AERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH--TGGPLLVHCR
..|..   |.     | .  |... . .| ..| |. . ...||| ||||.. ..|.. ..|  ..  . ||..||| 
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs
Y_phosphatase Protein-tyrosine phosphatase 313-485 3.6e-47 156.1 In-house 3-178 (235) alignment 
Range on Protein: 313-485
Range on HMM: 3-178/235.0
SKNRYRNVIPNKNTAVTLSGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPpPDTNDTEYYGP
.||||....|  .| | |.|.. .  |||||...||.  .|..|..|.|. .|| |||||.|. .|...|||.   | |..|||.|||  .......|| 
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.eeeeesltygd

FTVRNN-YEE-VLPFYKVVYLSVSINSDE-AERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH--TGGPLLVHCR
..|..   |.     | .  |... . .| ..| |. . ...||| ||||.. ..|.. ..|  ..  . ||..||| 
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs
subfamily_PTPRB_pd Subfamily PTPRB 275-484 3.9e-47 155.7 In-house 11-225 (293) alignment 
Range on Protein: 275-484
Range on HMM: 11-225/293.0
NFESFHLEDNA-KESIIGKEYKDIPMLLQDMSIWP---PDTYSKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPD
.||..  . .|  .  . .||...  . .|...     .   .||||.|..|  .. | |    ..  . |||||.|.||| ... .| .| |. .|. |
kfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvdd

FWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTNDTEYYGPFTVRNNYEEVLPFYKVVYLsvSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQ
||||.|| .....|||  ..|.|| || .|||  ..... .||  .|  . ||.|  . .  |  .|. ...||.|. . |. |||.||||.. ..|.| 
fWrmvwekkssiivmltqlvekgkvkCeeYWP..adeepvlyGdikvtlvaeeeledwvirel..kiekekeerkvrqyhftsWpdhgvPektktlldfv

EAVTIN----HTGGPLLVHC
..|  .    .. .|..|||
rtvreaiektaskrPivvhC
0037934 (Phosphotyrosine protein) phosphatases II 309-485 1.3e-46 154.5 In-house 8-186 (243) alignment 
Range on Protein: 309-485
Range on HMM: 8-186/243.0
PDTYSKNRYRNVIPNKNTAVTLSGesiaDRYINANFIDGYNgmeKaYICAQAPIYDTIPD----FWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdt
|   |||||....|.... | |.|    . |||||.|....   . .|. |.|  .|. |    ||||.|| .....|||.  .| |..|||.|||    
penlsknrysdilpydhsrvkleg....sdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....

nD-TeYYGPFTVRNNYEEVLPFYKVVYLSVSINS-DEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVT----------INHTGGPLLVHCR
 . . .||.|||..  ||.|. |.| .|...  . |. .| |. . . .|||.|||.   ..|.| ..|.           ...|||.||||.
.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 309-484 2.8e-45 149.6 In-house 45-219 (288) alignment 
Range on Protein: 309-484
Range on HMM: 45-219/288.0
PDTYSKNRYRNVIPNKNTAVTLSG--ESIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTND
.   .||||||..|   ..| | .  |     ||||..|||... .|.||..|.|. ||. |||....| ...|.||| .. ||||.|| .|||  |...
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk.kkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWP..dadk

TEYYGPFTVRNNYEEVLpfYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTG--GPLLVHC
 . || .||    .. |   ..|  .. .. .. |...  . ...||| ||||.. |.||. . | ....   ||..|||
pknyGsvtvtlveskel..edfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhC
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 311-484 2.8e-44 146.5 In-house 46-220 (318) alignment 
Range on Protein: 311-484
Range on HMM: 46-220/318.0
TYSKNRYRNVIPNKNTAVTLSGE--SIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTNDTE
   |||| |...  .| | |.    .    |||||.||||.  .|||| ||||. .||.|||||.|| |  ..|||  . | ||.|...|||    ....
nkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP...skgsr

YYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN---HTGGPLLVHC
 ||  .|  . |  |  | .  ..|. .  |..|.|  . .  ||| ||||... .|..   |.     .. ||..|||
sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhC
subfamily_PTPN6_pd Subfamily PTPN6 309-484 3.8e-44 145.9 In-house 52-234 (306) alignment 
Range on Protein: 309-484
Range on HMM: 52-234/306.0
PDTYSKNRYRNVIPNKNTAVTLSGESIAD-RYINANFID-GYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTND
|.  .||||.|..|  .| |.|. .|...  |||||.|.   .| .|.|| .|  . .|..|||||.|. | . .||.    | ||.|||.|||  |...
penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWP..deee

TEYYGPFTVRNNYEEVLPFYKVVYLSVS-INSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--H----TGGPLLVHC
.| ||  .|.|  |. |  |..  |||| ..... ||.|. . |. ||| |||.. | .|.| | |. .  .    . ||..|||
keeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhC
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 269-484 5.4e-44 145.5 In-house 7-223 (319) alignment 
Range on Protein: 269-484
Range on HMM: 7-223/319.0
LQELVRNFESFHLednAKESIIGKEYKDIPMLLQD--MSIWPPDTYSKNRYRNVIPNKNTAVTLSG--ESIADRYINANFIDGYNGmEKAYICAQAPIYD
.||| .... ..    . |  . ||.|.. .  .|   |   ..  .||||.|...  .| |.||   ..    ||||.|||||.  ....| .|||. .
vqeLkerlkalas...tgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqe.rekfiatqaPlen

TIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEA-ERDVMLFIFQGWPDFGVPEQAGP
|| |||||.|| .. .||||... | .| |. ||||   ... | || ..|  . || |  | .  |.. ..|.|   |.|. | .. ||| .|||.|  
tiedfWrmvWeeessivvmltklveklkvklkkywp...eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

ILEFQEAVTINHTG---GPLLVHC
.|.. . .   . .   ||. |||
lldllkrirksrektqsgPivvhC
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 290-484 7.8e-43 141.5 In-house 7-208 (274) alignment 
Range on Protein: 290-484
Range on HMM: 7-208/274.0
IGKEYKDIPMLLQDMSIWPPDTYSKNRYRNVIPNKNTAVTLSGESIADR---YINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCG
. ||. ..|.  .   .  . . .||||....||.|. |.|. ||  |    |||||.| ||.. .|||. .| |.  |. ||||||.. .|. .|||  
lekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

IFEGGKNKCAKYWPPPD-TNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDeaERDVMLFIFQGWPDFGVPEQAGPILEFQEAVT-----INHTGGPL
. |  ..|||.|.|    .. .| || . ....       |.|  |...  ..  ||.|. . .  |||  .|..| ..|.. . |       |.  .| 
lkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapv

LVHC
.|||
vvhC
subfamily_PTPN12_pd Subfamily PTPN12 309-484 1.1e-42 141.0 In-house 38-214 (290) alignment 
Range on Protein: 309-484
Range on HMM: 38-214/290.0
PDTYSKNRYRNVIPNKNTAVTLSGESIAD--RYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPdTND
. .. ||||....|  .. |.|| ..  .   ||||||| | .| ...|| ||.|. .|. ||||||||.||. |||.| ..| ||.||..|||   ...
eenvkknrykDilPydksrvelskieeeegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee.gee

TEYYGPFTVRNNYEEVLP-FYKVVYLSVSINsdEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVHC
.  .|.|.| .. |. .   . .  | |  .  ...| |  | .. ||| |||..| ..||. |.|     .   ||.|||
elefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhC
subfamily_Ptp69D_pd Subfamily Ptp69D 312-486 2.2e-42 140.3 In-house 49-228 (307) alignment 
Range on Protein: 312-486
Range on HMM: 49-228/307.0
YSKNRYRNVIPNKNTAVTLSGESIAD--RYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPdtnDTEY
  |||| ....  .| | |.     .   ||||.|| ||.  .| .|.||.|.  || ||||||.| .|...|||  . |  ..|||||||     |.  
alknRyedikafDktRvkLkkingkedsdYinasfikgyke.kkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...devq

YGPFTVRNNYEEVLPFYKVVYLSVSINSD-----EAERDVMLFIFQGWPDFGVPEQAGPILEFQEAV--TINHTGGPLLVHCRF
||   |.   ||  . |    |.|| . .     |..| |. . ..||.|. |||.|  .|.. | |    ..  .|..|||. 
ygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsa
subfamily_PTPRG_pd Subfamily PTPRG 309-485 2.5e-42 139.8 In-house 45-228 (563) alignment 
Range on Protein: 309-485
Range on HMM: 45-228/563.0
PDTYSKNRYRNVIPNKNTAVTLSGESIADR---YINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtN
|.   |||| |...  .. |.||. .  ..   |||||.||||.  .||.| .| |. ||. |||||||| ||...||.  . | |..||  |||    .
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk...d

DTEYYGPFTVRNNYEEVLPFYKVVYLSVSI-----NSD-EAERDVMLFIFQGWPDFGVPEQAGPILEF--QEAVTINHTGGPLLVHCR
..| || ..|.   ||||  | |  |..       ... . |. |. . .  ||| ||||.. | | |  ... . ... ||..|||.
esetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcs
subfamily_PTPN9_pd Subfamily PTPN9 311-472 1.6e-41 137.2 In-house 42-203 (297) alignment 
Range on Protein: 311-472
Range on HMM: 42-203/297.0
TYSKNRYRNVIPNKNTAVTLSGESIA--DRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpDTNDTE
  .|||| .|.   .| |.|. ..      ||||||.|||.  .||.| .| |.  |. |||||.|| .| ..||   . | |. ||..|||. ......
nleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl.eeessa

YYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVT
 .| ..|.|   |.   |||  | ..   .| .| |. | | .|||.|||..|  .|.. |.| 
efgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvr
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 310-484 1.9e-41 137.1 In-house 40-215 (281) alignment 
Range on Protein: 310-484
Range on HMM: 40-215/281.0
DTYSKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTNDT
.   ||||.|..   .| |..  . |.    ||||||..||.| ||.|| .|.|. ... .||.|.|| .|...||.    |.|| || .|||  | | .
envlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP..ddnse

EYYGPFTVRNNYEEVLPFYKVVYLSVsINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAV---TINHTGGPLLVHC
  || .||... ||  . |    ...  ...  .|.|  . .. ||| |||...  .|||...|   | ..|  ||..||
lkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihC
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 313-484 2.7e-41 136.4 In-house 22-204 (270) alignment 
Range on Protein: 313-484
Range on HMM: 22-204/270.0
SKNRYRNVIPNKNTAVTLSGESI--ADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTND-TEY
  |||....|. .| |.|. ..   |  |||||.. |..| .|.||.|..|   |. .||||||| .|...||. |. | |..||..|||.   .  .  
klnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkle

YGPFTVRNNYEEVLPFYKVVYLSVSiNSDEaERDVMLFIFQGWPDFGVPEQAG------PILEFQEAV---TINH-TGGPLLVHC
.|  .|..  ||   .| .  | .  .. | || .. | .. ||| |||....       .|.  .||   . ..  ..||||||
dgkikvlalseekeegyiltrlrle.ekge.errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 310-484 2.8e-40 133.4 In-house 55-230 (298) alignment 
Range on Protein: 310-484
Range on HMM: 55-230/298.0
DTYSKNRYRNVIPNKNTAVTLSG---ESIADrYINANFIDGYNGMEkAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTND
.  .|||| ..|.   . | |.    . ..| |||| |...|.| . |.| .|||.  |. |||||..| ...|.|||  . | .| |. ||||   .. 
enkkkNRyadiialdssRvvLekedadeesd.YiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP...deg

TEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH-TGG--PLLVHC
.| || .||.   .|.   . |. | || .. | || |  . |  ||| ||||.|  .|.. . |  ..   |  |..|.|
ketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqC
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 313-485 7.1e-40 131.9 In-house 51-220 (315) alignment 
Range on Protein: 313-485
Range on HMM: 51-220/315.0
SKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTndTEYY
 |||| |.|.  .. | |          |.|||||||||  .. ||.||.|   .. ||||...| .. ..||| .. || |.|. ||||  |      |
qknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp..dk..kviy

GPFTVRNNYEEVLPFYKVVYLsvSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTG--GPLLVHCR
|..||    |||   | |  |  |. ...  |.|. . .  ||| |||. . |....   |   ||   |...|||.
Gkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcs
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 311-484 1.3e-39 130.9 In-house 9-182 (250) alignment 
Range on Protein: 311-484
Range on HMM: 9-182/250.0
TYSKNRYRNVIPNKNTAVTLSGES---IADrYINANFIDGYNGMeKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNkCAKYWPppdTNDT
   |||| ..|. ... | |  |.   ..| |||| |..||..  ||.| .|.|. .|| |||||..| ...|.|||  . | .|. . .|||   .. .
nkeknryadiialdssrvvLekekgdkesd.yinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP...veka

EYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTG---GPLLVHC
| ||  ||    .|.   |..  | .| .. . || |  . |  ||| ||||.|  .||... |  ..     .|..|.|
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqC
subfamily_PTPRA_pd Subfamily PTPRA 312-484 4.4e-39 129.3 In-house 59-235 (330) alignment 
Range on Protein: 312-484
Range on HMM: 59-235/330.0
YSKNRYRNVIPNKNTAVTLS---GESIADrYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTNDTE
  |||. |..|.. . | ||   |.  .| |||| |||||.  .| .| || |  .|. |||||||| .  |.|||  . |  ..|||.|||   .. . 
keknrvvnilPydfsrvilsvkeGveesd.yinasfidGykekdk.fiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP...deGlv

YYGPFTVRNNYEEVLPFYKVVYLSVS----INSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI--NHTGGPLLVHC
 ||  .|  . |.||  | |  . |        ....| |  | |..|||.||| ..  .|.. ..|    . ..||. |||
tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhc
subfamily_PTPN3_pd Subfamily PTPN3 309-484 1.4e-38 127.4 In-house 39-215 (280) alignment 
Range on Protein: 309-484
Range on HMM: 39-215/280.0
PDTYSKNRYRNVIPNKNTAVTLSGESIadRYINANFIDG-YNG--MEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdTN
|.  ||||||...|  .| |.|. ..    |||||...   ..  . . || .| |. .|  |||.|.|| .....|||  . | |. || .|||   |.
penlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe..te

DTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINH--TGGPLLVHC
|.  || |.|. . |.    | .  | .. .. . || .. . .  ||| |||...  .||| | |   .  .  |..|||
deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC
subfamily_PTPN13_pd Subfamily PTPN13 311-484 1.2e-37 124.7 In-house 37-209 (273) alignment 
Range on Protein: 311-484
Range on HMM: 37-209/273.0
TYSKNRYRNVIPNKNTAVTLSGESIadrYINANFIDGYNGMEK-AYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEY
  .|||||||.|  .| |.|..|.    ||||..|    | ..  || .| |. .|. |||.|.|| ... ..|.    |.|| || .|||    . .  
nkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkv

YGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT-GGPLLVHC
.. ..|..   . |  ..|  | |. .  .. |.|. . |  ||| ||| .| ..|.|   |   .|  ||..|||
snrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhc
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 312-485 5.4e-36 119.0 In-house 4-180 (237) alignment 
Range on Protein: 312-485
Range on HMM: 4-180/237.0
YSKNRYRNVIPNKNTAVTLSGESIADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTNDTEYYG
  |||| |..    . | | |   .  ||||....|..|  | ||.|| |.  .  |||.|.|. .   .||| |. || . || ||||  .|.. . ||
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp..stdqpaayg

PFTVRNNYEEVLPFYKVVYLSVSINSDEAE-RDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI--NH--TGGPLLVHCR
 .||    .| .  | |  | .| .    | | .  . |  ||| |||.|.  .| |.  .    .|    || ..|| 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcs
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 313-489 5.9e-36 118.9 In-house 49-223 (287) alignment 
Range on Protein: 313-489
Range on HMM: 49-223/287.0
SKNRYRNVIPNKNTAVTLSGESiaDRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTNDTEYYGP
 |||......  |  | | ||   . |||| |||||.  .||.| |..|. .|. .||..|.. ||...||||   |  ...| .|||   .... ..|.
dknRltqilvpdnyrvllkgeh..pdyinavfidgyke.kkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWp...eeksvvlGe

FTVRNNYEEVLPFYKVVYLSVSINS-DEAERDVMLFIFQGWPDFG-VPEQAGPILEFQEAVTI--NHTGGPLLVHCRFTRL
....   |||   | .  | |  .. ..... |. . .  |.. | |.|..  .| ..| .     .. ....|||  |  
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvG
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 311-488 2.4e-35 116.8 In-house 46-227 (290) alignment 
Range on Protein: 311-488
Range on HMM: 46-227/290.0
TYSKNRYRNVIPNKNTAVTLSGE----SIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTnD
   .||..|.... .  .||         .. |||| .|.||.  .|.|| .|.|. .|. |||..||. .|  .|||. | | ||.|| .|||  |. |
nkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke.kkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWp..ds.d

TEYYGPFTVRNNYEEVLPFYKVVYLSVSINSD-EAERDVMLFIFQGWPDFG-VPEQAGPILEFQEAVTI--NHTGGPLLVHCRFTR
|. ||.|... . ||.|  |    |.|  ..  .|.. |. . .. |.. | |..... .| ..| . .   .. ....|||  | 
tkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtv
subfamily_PTPN23_pd Subfamily PTPN23 313-484 2.4e-35 116.7 In-house 45-219 (288) alignment 
Range on Protein: 313-484
Range on HMM: 45-219/288.0
SKNRYRNVIPNKNTAVTLSgeSIADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPpPDTNDTEYYGP
.|||.|...|  .. |.|   .  | |||| |. .   .   .|..|||.  |. |||.|..|  ....|||    | ||.|...|||  |...|. .|.
eknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP.edkgetvkfgd

FTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI------NHTGGPLLVHC
..|  . .. .. .    |...... .| ..|..  .. ||..|||.  . .|.| ..|        ...  ||.|||
lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhC
subfamily_PTPRK_pd Subfamily PTPRK 311-485 4.6e-35 115.9 In-house 43-218 (314) alignment 
Range on Protein: 311-485
Range on HMM: 43-218/314.0
TYSKNRYRNVIPNKNTAVTLS---GESiADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdtNDT
  .|||. ....  .. |.|    |..    ||||..||.|.   .|.| .| |. .|. ||||.... |  ..|||  . | |. || ||||    .||
nreknrsgdilaydrsrvflitidgdp.ssdyinaalidsykr.paafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP....edt

EYYGPFTVRNNYEEVLPFYKVVYLSVSI--NSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVHCR
| ||.. |     |.|  . |  ..|.    . |. | |  | | ||||..|| .|  .|..   |     .. |...||| 
evygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCs
subfamily_PTPN1_pd Subfamily PTPN1 311-485 6e-35 115.3 In-house 32-209 (290) alignment 
Range on Protein: 311-485
Range on HMM: 32-209/290.0
TYSKNRYRNVIPNKNTAVTLSGESIadRYINANFIDgYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEYY
  ..||||.| | . . ..|  ..   .||||....  . ... || .| |. .|.  ||.|.|| .  .||||  . | ...|||.|||  . ...  .
nrnlnryrdvspydhsrikleradn..dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekelll

G--PFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQ----EAVTINHTGGPLLVHCR
    ..|.   ||.  .|.|  | .   . .  |... | .  ||||||||  .  |.|     |. ....  || ..|| 
edtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 281-485 2.2e-34 113.7 In-house 12-218 (315) alignment 
Range on Protein: 281-485
Range on HMM: 12-218/315.0
LEDNAKESIIGKEYKDIP--MLLQDMSIWPPDTYSKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWEC
.. | . ... .|..|.|     .  .   .. ..||||.|..| ... | |    .|  . |||| .| ...  .||||..|.|   .. |||||... 
vnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqe

NVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEyYGPFTVRNNyeEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT
.| |.||.    || | ||..|||  ... .| .| . |     .. .    |   . .   |. | |  | |..||| ||..|.. .|..  .|  .. 
kvttivmvtkkqegdkikcrqywPdrkadsve.fGsikvell..sleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadng

--GGPLLVHCR
    .||||| 
kkefsllvhcs
subfamily_CG42327_pd Subfamily CG42327 288-466 3.6e-34 112.9 In-house 5-185 (319) alignment 
Range on Protein: 288-466
Range on HMM: 5-185/319.0
SIIGKEYKDIPMLLQDMSIWPPDTYSKNRYRNVIPNKNTAVTLS--GESIADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLC
. . .|..|.| |.      |. .  |.|. ||.|  .| |.|   |.   | |..|... ||.  .  ||.||..  |.  ||||..|| .  ..| |.
edvaeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

GIFEGGKNKCAKYWPPPDTND-TEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFqGWPDFGVPEQAGPILE
 ..| | ..||.|.|. .| | |. || . |     ||   | .  | .    .|  |..  . .  |.. .|| .  ... 
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaalia
subfamily_PTPN14_pd Subfamily PTPN14 280-472 5.4e-34 112.5 In-house 15-213 (300) alignment 
Range on Protein: 280-472
Range on HMM: 15-213/300.0
HLEDNAKESIIGKEYKDIPMLLQDMSI---WPPDTYSKNRYRNVIPNKNTAVTLSGE-SIADRYINANFIDGY-NGMEKAYICAQAPIYDTIPDFWRMIW
.|| . .|. . .||  ||   .|  .     |.  .|||...|.| ... | ||      . ||||  |     | |. || ||.|.  |. |||.|.|
ilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvW

ECNVNTVVMLCGIFEGGKNKCAKYWPPP-DTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVT
| .|. .|||  . |.||.|. ||.|   . ..|  .| | | ... |  . .    | .     . ||.|. . .. ||| ||||   . |.. | | 
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 284-485 1.2e-33 110.9 In-house 14-217 (515) alignment 
Range on Protein: 284-485
Range on HMM: 14-217/515.0
NAKESIIGKEYKDIP--MLLQDMSIWPPDTYSKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVN
| . ... .|..|.|   .  .        ..||||.|..| ... | |    ..    |.|| .| ...  .||||..|.|   .. ||||.... || 
nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvt

TVVMLCGIFEGGKNKCAKYWPPPDtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDeaERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT--G
|..|.    || | ||.||||     |.  .| . |     |         | |  ..|   | |  | |..||| |||...  .| .  .|  .|    
tiamvtklkegdkikcgkyWPdkp.gdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt

GPLLVHCR
 ||..|| 
hpliihcs
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 312-484 4.5e-33 109.9 In-house 62-231 (319) alignment 
Range on Protein: 312-484
Range on HMM: 62-231/319.0
YSKNRYRNVIPNKNTAVTL---SGESIADrYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCgifeggKNKCAKYWPppdTNDTE
  |||. |...  .. | |    ||  .| |||| |..||   .| || || |  .|. |||||||| |. |.|.|       |.||..|||    .  .
kdknriinilafdknvvklerliGeefsd.yinasfvtGyqrkdk.yiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp...lkivi

YYGPFTVRNNYEEVLPFYKVVYLSVSINS-DEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI----NHTGGPLLVHC
 .. | |. .  |    | |  . .| ..  .  |..  | |.|||| |||... ... . . |.     ..   ...|||
keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhc
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 313-484 9e-33 109.0 In-house 27-195 (284) alignment 
Range on Protein: 313-484
Range on HMM: 27-195/284.0
SKNRYRNVIPNKNTAVTL---SGESIADrYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCgifeggKNKCAKYWPppdTNDTEY
 |||. ....  .. | |    ||  .| |||| || ||   .| || .| |  .|. |||||||| |. |.|.|       |.||..|||    .  . 
dknrighilafdknvvklerliGeefsd.yinasfitGyqrkdk.yiatqGPldntladfWrmiweyncstivllt......kdkcsqywp...lkivik

YGPFTVRNNYEEVLPFYKVVYLSVSINSD-EAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI----NHTGGPLLVHC
.. | |. .  |    | |  . .| ..  .  |..  | |.|||| |||... ... . . |.     ..   ...|||
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc
0051429 (Phosphotyrosine protein) phosphatases II 337-485 1e-31 106.0 In-house 4-158 (272) alignment 
Range on Protein: 337-485
Range on HMM: 4-158/272.0
DRYINANFIDGYnGM---EKAYICAQAPIYDTIPDFWRMiWECNVNTVVMLCGIFEGGKNKCAKYWP---------PPDTNDTEYYGPFTVRNNYEEVLP
. ||||....|| |    .........|   |. ||||. .| ...|.|.|.. .| |..|| .|||         ..|.  |  || ..|.. .||.|.
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

FYKVVYLSVSIN-SDEAERDVMLFIFQGWPDFGVPEQAgpILEFQEAVTInhtGGPLLVHCR
.| . .| ...  | .. | ||.. ...|||.|||..|  .||. |..     |||.||||.
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCs
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 312-490 2.7e-31 103.4 In-house 39-223 (287) alignment 
Range on Protein: 312-490
Range on HMM: 39-223/287.0
YSKNRYRNVIPNKNTAVTLSGES-IADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPdtNDTEYY
 .|||| .|.|  .| | || |.     |||||.. .|.  ..|.|.||.||  |. ||||...| .. .|...    | ...|| |||| .  .     
vkknryadvlPiddtrvllsaegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer..evPmrv

GPFT-VRNNYEEVLPFYKVVYLSVsINSDEAE-RDVMLFIFQGWPDFGVPEQAGPILEFQEAV-------TINHTGGPLLVHCRFTRLL
| .. |  .|.   | | |  | . |. .  | | |  . .  ||| ...  |  .. |   |             |||.||.     .
GGysvvlldydikePeygvralrl.idletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 313-485 6.8e-31 102.2 In-house 50-220 (439) alignment 
Range on Protein: 313-485
Range on HMM: 50-220/439.0
SKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKnkcakYWPppdTNDTEYY
.||||..| .   | |||          |||||.|.||   .| || .|.|  .|  ||||...| .. |.|||. ..|  |     |||   ...  .|
tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyd.dklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywp...sdaevcy

GPFTVRNNYEEVLPFYKVVYLSVSINSD--EAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI---NHTGGPLLVHCR
|  .|| . .  || | .  . |  . |  | || |. | .  |||  || ||  .|.|  |.     ..  ||..||| 
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcs
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 311-485 8.9e-31 101.8 In-house 33-207 (283) alignment 
Range on Protein: 311-485
Range on HMM: 33-207/283.0
TYSKNRYRNVIPNKNTAVTLSGESIadRYINANFID--GYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdTNDTE
   |||.....|  .  | |  ||    |||| ||     .  .| || ||.|. .|. |||.|... .. ..|||  . |. . ||..|||    . .|
nkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP...krGse

YYGPFTVRNNYEEVLPFYKVVYLSVSIN-SDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI--NHTGGPLLVHCR
 ||.|||  . |     . .  | .  | | ...  .  . ...| ..|       .. |   ..   ..  ||..||| 
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCs
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 309-479 6.6e-30 99.0 In-house 31-201 (297) alignment 
Range on Protein: 309-479
Range on HMM: 31-201/297.0
PDTYSKNRYRNVIPNKNTAVTLSGESIADRYINANFIDGYNG-MEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNdT
. .  |||||...  ..| | | .      ||||...   .   .  ||.|| |. .|. |||....| .|...||.. . |.|..||| |||  . .  
nsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe.r

EYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTGGP
   | . |    .    | .|.   . .   . .| |    | .||| ||| .   .  ||  |.      |
lkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavp
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 309-485 2.7e-29 97.3 In-house 46-229 (325) alignment 
Range on Protein: 309-485
Range on HMM: 46-229/325.0
PDTYSKNRYRNVIPNKNTAVTLS--GESIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMI--WECnvnTVVMLCGIFEGGKNKCAKYWPPpDT
|.  .|||..||.. ... | |   ...    ||||...  . .  . .. ||||  .|| |.||..  |.|   .||..  ....||..||.|||  . 
penkaknrfknvvaldksrvvletkkddpssdyinasylrddkk.kdvflaaqaPltatindlWrlvldWrc...svvvvlneldlgkdrcavywpk.em

NDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEF-------QEAVTI-NHTGGPLLVHCR
 ..  .|.. |.    | .  |    | |   ..   | |  | .|.|.|.||...   .. .       .| ||   .. .|.|||| 
gksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 314-485 2.1e-28 93.9 In-house 43-234 (301) alignment 
Range on Protein: 314-485
Range on HMM: 43-234/301.0
KNRYRNVIPNKNTAVTLSGE----SIADRYINANFIDGYNGmEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDtNDTEY
 ||..|. . ..  ..|. .    .   .||||..||||.  .|..| ||.|.  |. ||||.||.  . ..||...  || |.|| .|||  . ...|.
lnrfknitvyddnriilkpkpnldlcqreyinasyidgyse.kkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnse.aesee

YGPFTVRNNYEEVLPFYKVVYLSVSI---------------NSDEAERDVMLFIFQGWPDFGV-PEQAGPILEFQEAVTI--NHTGGPLLVHCR
.|||||  . | |.| . .  |.| |               .|| . .||. .    ||. || .|..  .   .. .       |||..||| 
fgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCS
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 313-485 3e-28 93.6 In-house 10-182 (239) alignment 
Range on Protein: 313-485
Range on HMM: 10-182/239.0
SKNRYRNVIPNKNTAVTLSGESI--ADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdtNDTEYY
.|||| |..    . | |   |      ||||...  |.|  ||||..|  .  .  |||||.|.     .||| |. || |.|| .|||    . |  |
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp....dstsky

GPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTGG--PLLVHCR
  . |     ||.  | .  . .|   .  || |  . |  ||| |||. |  .| ..  .| .   |  | ..|| 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcs
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 313-485 3e-28 93.6 In-house 9-181 (239) alignment 
Range on Protein: 313-485
Range on HMM: 9-181/239.0
SKNRYRNVIPNKNTAVTLSGESI--ADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppdtNDTEYY
.|||| |..    . | |   |      ||||...  |.|  ||||..|  .  .  |||||.|.     .||| |. || |.|| .|||    . |  |
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp....dstsky

GPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTGG--PLLVHCR
  . |     ||.  | .  . .|   .  || |  . |  ||| |||. |  .| ..  .| .   |  | ..|| 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcs
subfamily_PTPRN_pd Subfamily PTPRN 310-485 3.8e-28 93.0 In-house 55-232 (297) alignment 
Range on Protein: 310-485
Range on HMM: 55-232/297.0
DTYSKNRYRNVIPNKNTAVTLSGESIA--DRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDtNDT
.. .|||...|.|  .. |.|. |. |  . |||| .|   .  . ||| .|.|. .|. |||.|.||  |  .|.|. . | | ..|..|||  | . .
knvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp..d.eGs

EYYGPFTVRNNYEEVLP-FYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTG--GPLLVHCR
| |. . |.   | .    | |  . .     .  | |  | |  ||. ||| .| ..|||.  |   . |   |..||| 
evyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcs
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 312-485 1.4e-27 91.6 In-house 52-225 (297) alignment 
Range on Protein: 312-485
Range on HMM: 52-225/297.0
YSKNRYRNVIPNKNTAVTLSGES--IADRYINANFIDGYNGmekAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKnKCAKYWPppDTNDTEy
..|.||.|..| .   |.|          |.|| |. |..     .|. | |  .|. |||.|... .|.|.|||    |. | |||.||.  |.  |. 
feksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs..dkgvtt.

YGPFTVRNN-YEEVLPFYKvVYLSVSINSDEAERDVMLFIFQGWPDFGVPE--QAGPILEFQEAVTINHTG---GPLLVHCR
.|  .|  .  .|   | |   |.|. ..  |.| |  . |  |||  |..  .|  .|.. . |  .. .   ||||||| 
fGdvsvvllsvsereGfik.relevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhcl
0041856 (Phosphotyrosine protein) phosphatases II 313-485 1.8e-27 91.5 In-house 3-117 (182) alignment 
Range on Protein: 313-485
Range on HMM: 3-117/182.0
SKNRYRNVIPNKNTAvtlsgesiADRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCgifeggknkCAKYWPppdtndteyygp
.||||....|. ..            |||||...|.    . .|..|.| ..|..||.||..| ...|.|.|.         .  |||            
dknrysdilpydhsr........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp............

ftvrnnyeevlpfykvvylsvsinsDEAERDVMLFIFQGWPDFGVPEqAGPILEFQEAVTInhTGGPLLVHCR
                         .. || .. ... .|||.|||.    .|.| |.|     ||| ||||.
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCs
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 302-485 4.1e-27 89.6 In-house 46-224 (290) alignment 
Range on Protein: 302-485
Range on HMM: 46-224/290.0
QDMSIWPPDT-YSKNRYRNVIPNKNTAVTLSGESIADrYINANFIDGYNGMekaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWP
 . .|.  .| . ||||..|. |  | | |.     | |. ||...| . |   .| .| .. ||. |.|||. . .| ..|||| ..| || ||..|.|
lerkifdkntefkknrykdvvcndktrvilkdGydGd.yvhanyvkGlkam...filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyyp

PPDtNDTEYYGPFTVRNNYEEVlPFYKVV--YLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEavTINHTGGPLLVHCR
  .  ..  .| .||    |.  .  ...   |||    .  |  .  .  . |||  |.  .  .|      .. .. ||. ||| 
eke.GevltfGeitvlcseedd.kdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlr..ilrkasGpvvvhcs
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 278-485 9.2e-26 85.1 In-house 11-177 (392) alignment 
Range on Protein: 278-485
Range on HMM: 11-177/392.0
SFhLEDNAKESIIGKEYKDIP--MLLQDMSIWPPDTYSKNRYRNVIPNKNTAVTL--SGESIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMI
.| .|.| . ... .|..|.|   . .. .   ..   ||||.|..| ... | |    ..  . |.|| .|....  |||||..|.|   .. |||||.
af.veknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfd.nekayiasqgpnaaslddfwrmv

WECNVNTVVMLCGIFEGGknkcakywpppdtndteyygpftvrnnyeevlpfykvvylsvsinSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI
.. || |..|.  . ||                                                .  | |  | |  ||| .||...  .|.| . | .
fqenvttiamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevka

NHTG--GPLLVHCR
..     ||..|| 
dfGqythpliihcs
subfamily_ptpA1_pd Subfamily ptpA1 312-472 5.8e-25 82.9 In-house 48-216 (418) alignment 
Range on Protein: 312-472
Range on HMM: 48-216/418.0
YSKNRYRNVIPNKNTAVTLSG--ESIADRYINANFIDGynGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPD------
 ||||| |..| . | | |    .     |||||.|||     | .||.| |. .|| |||||.||  .  .|||    |  . || .|||         
tsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

--TNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVT
   |  | .| ..|        |  ...   . .  .   ||.  . ..||||. .|... |. ..  ..|
iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsit
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 312-485 6.2e-25 82.5 In-house 56-229 (305) alignment 
Range on Protein: 312-485
Range on HMM: 56-229/305.0
YSKNRYRNVIPNKNTAVTLSGESiADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEYYG
 .||||..|  . ..|| |.  |    || ||..      || .|||| |. .|| .|| |. . .|. .||||   | || |||.|||    .  |  .
itknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks

PFTVRNNY----EEVLPFYKVVYLSVSINSDEaERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTinHTGGPLLVHCR
   | |       |  .  ..  | .. . |. .  |  . .  ||| |||      ||.  |.    .  |..||| 
givvenvsgskpmerdaeiqitllnltysgdq.kmsvrhlqwtewpdrgvppckltslellsair..gskvpivvhcs
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 313-484 1.1e-24 82.0 In-house 43-216 (307) alignment 
Range on Protein: 313-484
Range on HMM: 43-216/307.0
SKNRYRNVIPNKNTAVTLSGESIADRYINANFIdGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEYYG-
 ||||..|   ... . .  . .|  || ||.. |     | .|||| |  .|. .|| |. . .|..|.||| . | .| || .|||  . .   .   
dknryqdvkcqdkgrivvkfdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgea

PF--TVRNN-YEEVLPFYKVVYL-SVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHtgGPLLVHC
|   .| |   ... |  ... . .. ..  .  | .  . .. ||| |||.     ... |||  ..   |..|||
pntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt..npvvvhc
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 312-485 1.5e-24 81.1 In-house 53-231 (310) alignment 
Range on Protein: 312-485
Range on HMM: 53-231/310.0
YSKNRYRNVIPNKNTAVTLSG-ESIADRYINANFIDGyNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPppDTNDTEYY
  |||| .|.   .. | |    |  . || ||..   | . ...||.| |.  || ||||||..   .....|| . | |. ||  |||      || |
mhknrysdvvcldtsrvklkidksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp..slgvtety

GPFTVRNNYEEvLPFYKVVYLSVSINSD-----EA-----ERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHtgGPLLVHCR
|   | |  |     .... |.|..  |     |      |  | |  .  ||| |||..    .  .    . |  || .||| 
gcirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh..gpcvvhcs
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 290-501 2.3e-24 80.9 In-house 21-230 (288) alignment 
Range on Protein: 290-501
Range on HMM: 21-230/288.0
IGKEYKDIPMLLQDMSIWP-PDTYSKNRYRNVIPNKNTAVTLSgeSIADRYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIF
. |||.| |   .  .|    .. ...||.|.     | | ||    .| ||.|| .   .  ..  ||||||.  ||  .|.|. | .|. .|||| . 
lkkeyrdspneasidiidsfianptrdryenlprcditrvkls..ddpdfyiaanvvssak.ykrrlicaqaPlngtieelWkmllesdveyivmlcell

EGGKNKCAKYWPPPDTNDTEYYGPFTV-RNNYeevLPFYKVVYLSVSINSDEAERDV-ML-FIFQGWPDFGVPEQAGPILEFQEAVtiNHTGGPLLVHCR
| ||.| |.|.|    . . .    || ....       |.| .|.  .| | |  | .    .. |.| ||||.  . | . | .  . .  |..||..
ekGkeksaeyfPsklGekarigrlctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqkPivvhss

F--TRLLSLMFHMLLLKD
    |   |.. .. |. 
aGvGrtgtlililiales
subfamily_CG7180_pd Subfamily CG7180 312-471 2.6e-23 77.1 In-house 43-210 (296) alignment 
Range on Protein: 312-471
Range on HMM: 43-210/296.0
YSKNRYRNVIPNKNTAVT---LSGESIADrYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKnKCAKYWPPPDtndTE
  |||. .|.|  .. |    | ||.  | |||| ..|..   .|.||  .||  .|. .|||.... ....||.|.  |.  | .. .|||.      |
reknrdvkvvPyDynRvvLekldGeeksd.Yinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks...ke

YYGPFTVRNNYEEVLPFYKVVYLSVSIN----------SDEAERDVMLFIFQGWPD-FGVPEQAGPILEFQEAV
 ||.. |    |. ..  |   . .  .           .  .| |.|| .. |.    ||  .  ..|. . |
qygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv
0049772 (Phosphotyrosine protein) phosphatases II 311-485 4.1e-23 78.0 In-house 46-220 (314) alignment 
Range on Protein: 311-485
Range on HMM: 46-220/314.0
TYSKNRYRNVIPNKnTAVTLSGESIAD-RYINANFIDGYngmeKAYICAQAPIYDTIPDF----------WRMI--WECNVNTVVM--------------
  .|||| ...|   . | |.|... .  ||||...||.    ...|..|.|   |. ||          |||.  .. || ..||              
nrdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCGIFEGGknkcakywpppdtndteyygP----------FtvrnnyeevlpfykvvylSVSINSDEAERDVMLFIFQGWPDFGVPeQAGPILE
       |... ..|                    .                             ..  . .  || .. ..   .||...|     ..|
aAlgKtpllildgng....................neptaadlellk..................eelydpelferlgikylripvpDgsap.lledfde

FQEAVTINHTGGPLLVHCR
| |..  ...|||.||||.
flefieeadkggpvlvHCk
0036282 (Phosphotyrosine protein) phosphatases II 337-485 4.5e-23 77.2 In-house 2-112 (174) alignment 
Range on Protein: 337-485
Range on HMM: 2-112/174.0
DRYINANFIDGYNGMEkAYICAQAPIYdtipdFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpdtndteyygpftvrnnyeevlpfykvvylsvsiN
..||||...|..   .  .|. |.|       ||.|..| ...|||||.  .| |. ||  |||                                   .
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................l

SDEAERDVMLFIFQGWPDFGVPEQAGpILEFQEAVTIN---HTGGPLLVHCR
..  || .. ... .|||.|||. .  .||| ..|      . |||.||||.
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCs
0046846 (Phosphotyrosine protein) phosphatases II 337-485 6.6e-23 76.8 In-house 12-117 (176) alignment 
Range on Protein: 337-485
Range on HMM: 12-117/176.0
DRYINANFIDGYngmekAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTeyygpftvrnnyeevlpfykvvylsvsin
  |||||.|.|.     ..|. |.|...|..||..|..| ....||.|.  .| |. ||. |||   ...                              
ldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

sdeaerdvmLFIFQGWPDFGVPEQaGPILEFQEAVTINH-TGGPLLVHCR
          ... .|||.|||.    .||. |..      ||| ||||.
.........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCs
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 312-485 5.8e-22 72.8 In-house 49-227 (305) alignment 
Range on Protein: 312-485
Range on HMM: 49-227/305.0
YSKNRYRNVIPNKNTAVTLSGeSIADRYINANFIDGYnGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEYY-
  ||||..|    |  | | | .    || ||..       | .||.|||. .|  ||| | .. .|... ||| . | | .||..|..  | .  |.  
agknrykdvgcldnnrvkleg.pwpheyihanyvstp.tnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

--GPFTVRNNYEEVLPFYKV-----VYLSVSIN-SDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTinHTGGPLLVHCR
     .|. .  . | | |          . |. . |  | |  . .  ||| |||     |||. |      . ||. ||| 
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar..pskgpivvhcs
0043147 (Phosphotyrosine protein) phosphatases II 338-485 2.8e-21 71.4 In-house 6-108 (172) alignment 
Range on Protein: 338-485
Range on HMM: 6-108/172.0
RYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIfeggknkcakywpppdtndteyygpftvrnnyeevlpfykvvylsvSINS
 ||||...|.|  . . .|. |.|   |..|||||..| .....|.|..                                                 . 
dyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..............................................lydp

DEAERDVMLFIFQGWPDFGVPeQAGPILEFQEAVTI---NHTGGPLLVHCR
.  || .. ... .|||.|||  .  .||| | .     .  ||| ||||.
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCs
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 311-485 3.2e-21 70.2 In-house 37-208 (281) alignment 
Range on Protein: 311-485
Range on HMM: 37-208/281.0
TYSKNRYRNVIPNKNTAVTLSG---ESIADRYINANFIDGyNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpDTNDT
   |||| |.     . | |     .  .  || ||.|     ... || .| |  .|  |||||||. |  ..|||| . |  ..|||.|.|  ..   
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr.nahcc

EYYGPFTVrnNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTggPLLVHCR
  .  ..|  .||.      .|   . .  .   | .  .... |||. ||| .  .|.    .    |  | ..|| 
lqfdklsv..syedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarst..ppvihcs
0049260 (Phosphotyrosine protein) phosphatases II 350-485 5.7e-21 70.2 In-house 6-97 (152) alignment 
Range on Protein: 350-485
Range on HMM: 6-97/152.0
GMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWpppdtndteyygpftvrnnyeevlpfykvvylsvsinsdeaerdvmLFIF
.| ...|..|.|   |..|||||..| ...|.|||.  .| || ||..|.                                               ...
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................qylh

QGWPDFGVPEQAGPILEFQEAVTI--NHTGGPLLVHCR
  |||.|||. .  .|.. ... .   . ||| ||||.
lpwpDhgvpdlsqlllflllfieklaldkggpvlVHCs
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 288-484 2.9e-20 67.4 In-house 6-199 (267) alignment 
Range on Protein: 288-484
Range on HMM: 6-199/267.0
SIIGKEYKDIPMLLQDMSI----WPPDTYSKNRYRNVIPNKNTAVTLSGESIAdrYINANFIDGYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVM
  | ||.. |  . .. |     .. .   .||. ...| ..| | |. .     |||| ...||.  ..|.|  | |.  || ||. .| . .| ..|.
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee..yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivl

LCGIFEGgknKCAKYWPPpDTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSdEAERDVMLFIFQGWPDFG-VPEQAGPILEFQEAVTINHTGGPLLV
|  .|..   .  ..|||    ... |  .||  . |.    |... | . ..  |. ..| |. .. |           |..       ..  . ||.|
ltkvftd...nirlfwPP.kmgqakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvv

HC
.|
ac
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 314-485 3.8e-20 67.0 In-house 38-211 (285) alignment 
Range on Protein: 314-485
Range on HMM: 38-211/285.0
KNRYRNVIPNKNTAVTLSGEsiADRYINANFIDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPdTNDTEYYGPF
 ||| .|   ..| | |        || |...      . .|| .| |. .|. |||.||.. ..  |.||| .|||| .||| |.|     .   .| .
lnryadvrcieetrvvlknh..drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek.lgevvkfgky

--TVRNNYEEVLPFYKVVYLSVsINSDEAERDV-MLFI--FQGWPDFGVPEQAGPILEFQEAV-TINHTGGPLLVHCR
  |. .  || .    .  |.| ||...|  .   .       |||   ||.| |..|. . |  .|    |. ||| 
eitlteckeeaiagtilnaltv.intedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcs
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 313-485 1.2e-19 65.2 In-house 52-222 (301) alignment 
Range on Protein: 313-485
Range on HMM: 52-222/301.0
SKNRYRNVIPNKNTAVTLSGESiADRYINANFIDGYnGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTNDTEyYGP
 |.|| .|  . .||| .  .      | ||.|.   |  . .|..|.|. .|  ||| |.   .|...|||.   |  ..||..| |   ... .  | 
dkhryptvPckPstavevivdG.krvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld.igr

FTVRNNYEEVLPFYKVVYLSVSIN--S-DEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVtiNHTGGPLLVHCR
|... . .|..   |..  .. ..  . . | | |. . .. |.| |||.    . .. | |   ..  |..||| 
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelv..kksekPivvhcs
0051082 (Phosphotyrosine protein) phosphatases II 337-485 7.2e-19 63.3 In-house 3-100 (151) alignment 
Range on Protein: 337-485
Range on HMM: 3-100/151.0
DRYINANFIDGYngmekaYICAQAPiydtIPDFWRMIWECNVNTVVMLCGIFEGGknKCAKYWPPPDtndteyygpftvrnnyeevlpfykvvylsvsin
. |||.....|.      ... ..|     .||.....| ...|.|.|.. .| |  .|..|.|  .                                 
sdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

sdeaeRDVMLFIFQGWPDFGVPEQAGPILEFQEAVTiNHTGGPLLVHCR
     ..|. . . .|||.|.|.    .||| |..  .. .||.||||.
.....ievlhipildwpdpglplsfdavleflelll.dkkngpvlvHCs
0044763 (Phosphotyrosine protein) phosphatases II 338-485 5.1e-18 60.8 In-house 19-118 (178) alignment 
Range on Protein: 338-485
Range on HMM: 19-118/178.0
RYINANFIDGYngmekAYICAQAPiydtiPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPPDTndteyygpftvrnnyeevlpfykvvylsvsins
.||||..|...      |.... |     .|......| .....|.|.. .|.|..|| .|||                                     
dyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................................

deaerdvMLFIFQGWPDFGVPEQAGPILEFQEAVTIN--HTGGPLLVHCR
       . ... ..||.|||.    .||| |..       ||| ||||.
.......iqylhipipDhgvpdllehflefvefieealdekggpvlVHCs
subfamily_egg_pd Subfamily egg 328-444 1.1e-17 58.6 In-house 57-174 (307) alignment 
Range on Protein: 328-444
Range on HMM: 57-174/307.0
VT--LSGESIADRYINANFIDGYNGMeKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGgkNKCAKYWPPPDTNDTEY-YGPFTVRN--NYEEV
|.  |     .| .| || ..|   .   .|.||||. .|  |||||... .|. .|||    |   ..|  |||  ...   .  | . . |   ... 
vklelrrGqylddfihanrvkGkpll.nefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdska

LPFYKVVYLSVsINSDEAERDV
 |...|  | . . .|. || .
dplfrvtklkl.vGgddeerfl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 307-456 9.4e-16 52.2 In-house 92-234 (244) alignment 
Range on Protein: 307-456
Range on HMM: 92-234/244.0
WPPDTYSKNRYRNVIPNKNTAVTLSGESIADRYINANFIdGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGgknkcAKYWPppDTND
. |.   |||    .|     | ||  |... |||| |. |  |    || .| |. ||  |||.|. |  || .|.|  . |       .|||  |.. 
fnpnnswknregaglpfdfnrvplskgsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp..dsep

TEYYG-PFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFG
 |.|    ||     . .   |   | .  . .|. . . .|    ||  |
lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 311-406 2.1e-15 51.3 In-house 47-157 (350) alignment 
Range on Protein: 311-406
Range on HMM: 47-157/350.0
TYSKNRYRNVIPNKNTAVTLS-----------GESIADrYINANFIDGY---NGMEKA--YICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNK
...||||.|..|   . | |              |  | |||||..        ..    || .|||.  |. ||...| . .|. ...|   .| . .|
lfaknrYknilPYehsrvkLkkslkssdakkhslstnD.YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CAKYWPPPDTND
| .||.  . .|
cyrYWqegsydd
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 291-484 2.6e-14 47.6 In-house 22-216 (312) alignment 
Range on Protein: 291-484
Range on HMM: 22-216/312.0
GKEYKDIPMLLQDMSIWPPDTY-SKNRYRNVIPNKNTAVTLSGESiaDRYINANFIDGYNGMEKaYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFE
 |||| .  ...|        .   ||| |.        ||.|.   . || |||.      |. ..|.|.|. .|.  ||..       ....|||. |
tkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagde..nfyihanfvkictkper.fvctqgplentcthfwqlalslgstsiillcgfve

GGKNKCAKYWPPP----DTNDTEYYGPF----TVRNNYEEVLPfYKVvyLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHtgGPLL
 | .|||||        | .|   |  .     .  .  . .  ..|  | | ...   |  .  . .  ||| |.|.     | .  ||  ..   |..
dgsekcakyisdivgfvdledhrvyteycteieiggkskdkit.hrv..lkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk..kpvi

VHC
 ||
ahc
subfamily_eak_pd Subfamily eak 318-489 5.3e-13 43.1 In-house 58-223 (332) alignment 
Range on Protein: 318-489
Range on HMM: 58-223/332.0
RNVIPNKNTAVTLSGE-SIADRYINANFIDgYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPpPDTNDTEYYGPFTVR
 ...|..   | |.      . ||||  .. .. . . || . ..  | .. ||.|. | .  ..|.|    | . .|  ||.|  .| .   .| . | 
vkivpydrylvrltssqlnrlGyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp.dktreelkfGildve

N-NYeEVLPFYKVVYLSVSinSDEAERDVMLFIFQGWPDFGVPEQAgPILEFQEavTINHTGGPLLVHCRFTRL
  ..      ...  | .|    .    |. . . || .. .|      | ...  .. ..| .||.  . . |
rkef.vkrniletrllels..kGnethrvlhykvfGwtettlpkye.dflalrk..vmkevGvlllivmksall
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 345-484 5.9e-12 39.6 In-house 83-228 (302) alignment 
Range on Protein: 345-484
Range on HMM: 83-228/302.0
IDGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpDTNDTEYYGPFTVR-----NNYEEVL-----PFYKVVYLSVS
.|| . .||       |  .|.  .| .| . ||  || ||.. |....|||.|.   . ...  .| .||.     .. ||        .|.| .    
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysd.kvggelkfgrytvktvsvktdleeftdkksfklytveiknek

INSdEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTINHTGgpLLVHC
 .. . .. | .. | .||| | |..| . |.         .   .||||
kkk.kvkktvdilafsawpdhGapkeaytaldilkfcesykkn..vlvhc
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 328-400 2.3e-11 37.7 In-house 81-154 (349) alignment 
Range on Protein: 328-400
Range on HMM: 81-154/349.0
VTLSGESIADRYINANFIDGY-NGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWP
 . |  .. | |||||..      .|| ||. |||.  |. ||...|   .|. |. |   .| . .|| .|| 
tsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 365-485 7.9e-11 36.5 In-house 40-156 (255) alignment 
Range on Protein: 365-485
Range on HMM: 40-156/255.0
TIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpDTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPI
|.  |...|   . ..|||||   | |..|| .|.|  . ..   .   .|        .  . . .   .      ..|  . ..||..   ||.|  |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl.ekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LEFQEAVTINhtgGPLLVHCR
|.   .|.      ...||| 
lnilkvvrds...ksvvvhCs
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 337-456 1.1e-10 35.9 In-house 13-125 (130) alignment 
Range on Protein: 337-456
Range on HMM: 13-125/130.0
DRYINANFIdGYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEggknkCAKYWPppDTNDTEYY-GPFTVRNNYEEVLPFYKVVYLSVSI
. ||||.|. |  |  . |. .|.|. ||  |||.|. |  || .|.|  . |       .|||  |..  |.|    .|     .   . |  .| .. 
ntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywp..dsePlewyeediivtltdrdefknikasnleies

NSDEAERDVMLFIFQGWPDFG
.  |. . . .|    ||  |
dlneshqaltmfqisnwpsdg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 324-485 4.5e-10 34.1 In-house 33-199 (290) alignment 
Range on Protein: 324-485
Range on HMM: 33-199/290.0
KNTAVTLSGESIADRYINANFIDGYNGMekAYICAQAPIYDT-------IPDFWRMIWECNVNTVVMLCGIFEGGKN----KCAKYWPPPDTNDTEyYGP
   .    |. ..| || ||..   ||.  . |  |.|  ..       | .|| |. . .|. |||||   |  .|     |||| |    ..   .. 
trvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelk.fkg

FTVRNNYEEVLPFYKVVYLSVSINsDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTinHTGGPLLVHCR
.||.    |     ..  | |  . || |  |    ..|| .  |.|.   .|.  . |     . | .||| 
ltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 353-459 8e-10 33.2 In-house 5-112 (199) alignment 
Range on Protein: 353-459
Range on HMM: 5-112/199.0
KAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCgifEGGKNKC---AKYWPPPDtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINS--DEAERDVMLF
. ||..| |. .|. |||.|.||     .||.    .  |||    . |||  . . |  || ..|  .   . | | .. | .. |.    . |..  .
rryiatqhplretmadfwqmvwetgsghivmvn...ddqknkeadypfywptte.sgtgkygslsvttktittkpdytitaliltnnttappstreishy

IFQGWPDFGVPE
 |  | .   |.
qftswkekttpn
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 353-459 8.5e-10 33.1 In-house 4-111 (198) alignment 
Range on Protein: 353-459
Range on HMM: 4-111/198.0
KAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCgifEGGKNKC---AKYWPPPDtNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINS--DEAERDVMLF
. ||..| |. .|. |||.|.||     .||.    .  |||    . |||  . . |  || ..|  .   . | | .. | .. |.    . |..  .
rryiatqhplretladfwqmvwetgsghivmvn...ddqknkeadypfywptte.sgtgkygslsvttktittkpdytitaliltnnttappstreishy

IFQGWPDFGVPE
 |  | .   |.
qftswkekttpn
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 347-428 9.2e-10 32.4 In-house 231-306 (440) alignment 
Range on Protein: 347-428
Range on HMM: 231-306/440.0
GYNgMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMLCGIFEggkNKCAKYWPPpDTNDtEYYGPFTVRNNYEEVLPFYKV
||    .|.|..| |.  |. ||||.. . .. |..||  . .   . |. |||  .|     .|||||  .  | .   ||
gys.kknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpv.ntrs.vtfgpftvghkgsenmnrvkv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 312-393 1.4e-09 31.9 In-house 38-122 (347) alignment 
Range on Protein: 312-393
Range on HMM: 38-122/347.0
YSKNRYRNVIPNKNTAVTLSGESI-------ADRYINANFIDgYNGMEKAYICAQAPIYDTIPDFWRMIWECNVNTVVMlcgIFEGGKN
 |||| ..|  . .| | || |         .. ||||  |  ..  .| || .| |. ||. |||.|.   .|  ||    |||  |.
lsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt...ifepikd
0048076 (Phosphotyrosine protein) phosphatases II 405-485 1e-08 30.5 In-house 8-89 (145) alignment 
Range on Protein: 405-485
Range on HMM: 8-89/145.0
NDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTI-NHTGGPLLVHCR
 .  |.|.... ...|.   .     |... . .  || .. ... .|||.|||. .  .||| |..      ||| ||||.
lpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCs
subfamily_hpo-7_pd Subfamily hpo-7 362-484 2.2e-08 28.3 In-house 43-161 (263) alignment 
Range on Protein: 362-484
Range on HMM: 43-161/263.0
IYDTIPDFWRMIWECNVNTVVMLCGIFEGGKNKCAKYWPPpDTNDTEYYGPFTVRNNYEEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQA
. .||. |...|   . ..|||||   | |..|| .|.|  . ..   .   .|        .  |   |   ..     ..|  . ..||..   ||.|
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPl.ekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

GPILEFqeaVTINHTGGPLLVHC
  ||.    . ..    .| |||
reilni...lkvarnskslvvhc
0048179 (Phosphotyrosine protein) phosphatases II 406-485 7.3e-08 27.8 In-house 9-91 (144) alignment 
Range on Protein: 406-485
Range on HMM: 9-91/144.0
DTEYYGPFTVRNNYEEVL--PFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN-HTGGPLLVHCR
.  |.|.. . ...|.     .. |. |. .   .. || .. ... .|||.|||. .  .||| |..      ||| ||||.
pglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCs
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 313-386 8e-08 26.2 In-house 49-116 (303) alignment 
Range on Protein: 313-386
Range on HMM: 49-116/303.0
SKNRYRNVIPNKNTAVTLSGESiadrYINANFIDgYNGMEKAyICAQAPIYDTIPDFWRMIWECNVNTVVMLCG
 |||. .||    . | ||  |    || |....  .   || | .| |.  |  |||.|| | .|. |..|  
dknrfvdvicldhskvklsdss....yihasyle.ldsskka.iltqlplshtaadfwqmiieqkvkcvllllt
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 320-395 1.6e-07 25.1 In-house 43-118 (332) alignment 
Range on Protein: 320-395
Range on HMM: 43-118/332.0
VIPNKNTAVTLSGESIADRYINANFIDGYNgMEKAYICAQAPIYDTI-PDFWRMIWECNVNTVVMLCGIFEGGKNKC
.     . | |. .   | . ||...|||.  . ||| ||||. |     ||||. | . . ....  | |  | |.
lycfdhsrvelapqdgkddfynaswvdgys.kksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 311-359 3.8e-07 24.2 In-house 48-94 (95) alignment 
Range on Protein: 311-359
Range on HMM: 48-94/95.0
TYSKNRYRNVIPNKNTAVTLSGESIADrYINANFIDGYNgMEKAYICAQ
   |||. |..|   | |.|.    .| |||| |.|||    ..||.||
nipknrflnifpydatrvvlttkrdsd.yinacfvdgya.rkncyiaaq
PTPc_DSPc_SM00012 444-485 9.8e-07 24.3 In-house 2-47 (105) alignment 
Range on Protein: 444-485
Range on HMM: 2-47/105.0
VMLFIFQGWPDFGVPEQAGPILEFQEAVTINHT----GGPLLVHCR
|. . . ||||.||||.. .|||. .||  |..    ..|..|||.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 420-485 2e-06 21.4 In-house 67-135 (440) alignment 
Range on Protein: 420-485
Range on HMM: 67-135/440.0
EEVLPFYKVVYLSVSINSDEAERDVMLFIFQGWPDFGVPEQAGPILEFQEAVTIN---HTGGPLLVHCR
|||    .  |.  |  .    | .  . .||||| |||. |||.|.. . |  .      ||||||| 
eevkgvpdsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcs
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 285-462 4.3e-06 20.4 In-house 23-201 (302) alignment 
Range on Protein: 285-462
Range on HMM: 23-201/302.0
AKESIIGKEYKDIPMLLQDM---SIWPpDTYSKNRYRNVIPNKNTAVTLsgESIADRYINANFIDGYNgMEKAYICAQAPIYDTI---PDFWRMIWECNV
 ... . ||.| |  .  |.   ...  .  .||.  .|    .. | |  |  .| |.||  ..  . ...  | || |. |.     .||||... ..
ldtaevkkefkkidtmkvdlekCkafk.knlkknqsedvpildsnlvkl..eaepdsyvnaskvevPe.ltrsiilaQlpkvdsedsveeFWrmvfqeki

NTVVMLCGIFEGGKnKCAKYWPpPDTNDTEYYGPFTVRNNYEEVLPFYKvVYLSVSINSDEAERDVM--LFIFQGWPDFGVPEQAG
 .||.| |  |  |    ...|   ..| ..|| . | |   |     |   ... .  ..    |.  . ... |..  ||.. .
vsvvilvgeeelkk.tlselfp.kksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkya