Gene PTPN14 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN14
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP050_AA protein Get Run
AqueP050_AA_512-796 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN14_pd Subfamily PTPN14 507-799 1.7e-147 485.2 In-house 2-300 (300) alignment 
Range on Protein: 507-799
Range on HMM: 2-300/300.0
QEATSGTRDKRAQHLEMILQSGKVYPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTgSNDYINASLVSYSVGSQHRSYIVCQG
.|||. |.||||..||..|..|||..|.|.||....||..|....|.||.|||.||..|||.||..|.|.|.. |..||||| ...|||...|||||.||
eeatratkdkrakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqg

PLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENAKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPP
|||.|..|||||.|||..|||.|||...|.||.|...|||..|...|.|.|......|||.|.|.||||........|..|||....|||.||||||.|.
PleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPe

DPQPFISYLRMVKSLRYKFDESI-------PIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINNAR
|...|.|||..|.|.|.|.....       |..|||||||||.|||.|||.|..|....|.||||..||||| |||.|||||.||.|.|.|.|||..|.|
DvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylknsr
0050432 (Phosphotyrosine protein) phosphatases II 493-797 3.9e-91 300.9 In-house 7-301 (308) alignment 
Range on Protein: 493-797
Range on HMM: 7-301/308.0
KTPPPLLSPDTQWEQEATSGTRDKRAQHLEMILQSGKVYPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLnpnknTGSNDYINASLVSY
 ....||  ||.. .. .  . .. ...||  |..|... ||||.. .  . ..|... | | .|||||||.||.|.|..|      ...||||||.|. 
allelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdg

SVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENaKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIM
 .  . | .|..||||. |. |||.|.|||....| |||...|||. ||.||.|..... . ........ .. .|. .....| ... .. ..|.|...
yssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgg.gsleygkftvtllseevlddytvrtleltnlgdgesrtvt

ILQYIDWPDHGIPPDPQPFISYLRMVKSLRykfdESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVII
...|..|||||.||.|......|..|.. .    .. ||||||||||||.|.... |.| | ....  .|. . ...|| ||.. |||. ||.||| ...
hfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall

KYINN
.|...
eylkl
0036941 (Phosphotyrosine protein) phosphatases II 525-797 4.1e-87 287.5 In-house 10-279 (297) alignment 
Range on Protein: 525-797
Range on HMM: 10-279/297.0
LQSGKVYPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLnpnkNTGSNDYINASLVsySVGSQHRSYIVCQGPLEITCCDFWQMIWEQKT
|.. ... ||||..|. |. ..|....| | .|||||||.||.|.|..|    . ...||||||.|  .. .. | .|..||||. |. |||.|.|||..
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmvweqnv

QLILMLTNIIENGKTKCHQYFPNDEENAKHvqFEQYRISTKFVEK--SPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLR
. |.|||. .|.|. ||.||.|..|.. .   ...... .. ||.  ......| ..| .. ..|.|......|..|||||.|..|.........|.. .
tvIvmltelvelgrekcaqywpleegeslt..ygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

YKFDESIPIVVHCSAGVGRSGVLVLSDMLTETYD---CGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
 .. .. |..|||||||||||.... |.. . ..     . .||.. .  || ||.. ||||.|||||| ........
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0051299 (Phosphotyrosine protein) phosphatases II 528-795 5.6e-87 287.1 In-house 23-286 (288) alignment 
Range on Protein: 528-795
Range on HMM: 23-286/288.0
GKVYPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVsySVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLI
 ... ||||....  | ..||.. | | .||||.||.||.|.|..|.. .. ...||||||..  ..  . | .|..||||. |. |||.|.|||....|
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi..dgynlkrkfIatqgPlpntvedFWrmvweqnvrvI

LMLTNIIENGKTKCHQYFPNdeenAKHVQFEQYRISTKFVEKSPSVITRCFTVHYM----PTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRY
 |||...|.|..||.||.|.     .......... .. .|. .....| ..| ..    ...|.|......|..|||||.|..|......||.|.. . 
vmltklvelgrekcaqYwpl....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

kfDESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
  . . |.||||||||||.|.... |.| | .......|. . ..||| ||...|||. ||||.| ... |.
..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 526-796 8.8e-85 280.0 In-house 16-277 (317) alignment 
Range on Protein: 526-796
Range on HMM: 16-277/317.0
QSGKVYPEFEEIPPMSLDaDTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVsySVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQ
. .... |||... ..|| ..| .. |.| .||||.||.||.|.|..|.| ..  ..||||||.|  .. .. | .|..||||. |. |||.|.|||...
dftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrkfIatqgPlpntvedFwrmvweqgvt

LILMLTNIIENGKTKCHQYFPNdeenAKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYkf
.|.|||.  |.|. ||.||.|.     . ........ .. .|. .... |...| .. .||.|......|..|||||.||.|..... |..|.. .   
vivmLteleelgrekcaqYwpl....getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..

DESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
|.. |..|||||||||.|.... ... |  . .. .|... ...|| ||.. |||..||||||.....|..
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
0046845 (Phosphotyrosine protein) phosphatases II 531-797 1.1e-84 279.4 In-house 3-276 (284) alignment 
Range on Protein: 531-797
Range on HMM: 3-276/284.0
YPEFEEIPPMSLDA--DTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNT-GSNDYINASLVSYSVG---SQHRSYIVCQGPLEITCCDFWQMIWEQKT
. ||||.. .  .   ..|..  | | .|||||||.||.|.|..|.. ... ...||||||.|.        ... .|..||||. |. |||.|.|||..
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

QLILMLTNIIENGKTKCHQYFPNDeenAKHVQFEQYRISTKFVEKSPSVITRCFTVHYMP-TSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRY
..| |||...|||..||.||.|..    . ........ .. .|. .....| ... ..  |.|.|......|..|||||.||.|......||.|..|. 
rvIVmltelvengrekcaqYwple...gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

KFDESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGE---VIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
... . ||||||||||||.|.... |.| | .. ..   ..|. . ..||| ||.. |||| ||||.| ... |...
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0047943 (Phosphotyrosine protein) phosphatases II 526-795 1.1e-83 276.2 In-house 10-272 (273) alignment 
Range on Protein: 526-795
Range on HMM: 10-272/273.0
QSGKVYPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLnpnkNTGSNDYINASLVsySVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQ
...... |||.....  . ..|... | | .|||||||.||.|.|..|    . |..||||||.|  ..  . | .|..||||. |. |||.|.|||...
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv..dgynlkrkfiatqgPlpntvedfwrmvweqnvr

LILMLTNIIENGKTKCHQYFPNDEENaKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKF
.| |||...|.|. ||.||.|.....  ......... .. .|. .....| ... .. |.|.|......| .|||||.||...........|.. . ..
viVmLtelvelgrekcaqYwplegge.lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

DESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
 .. |.||||||||||.|.... |.| . . ..  .|... ...|| ||.. |||. |||||| ....|.
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 501-797 9.5e-83 273.3 In-house 5-291 (297) alignment 
Range on Protein: 501-797
Range on HMM: 5-291/297.0
PDTQWEQEATSGTRDKRAQHLEMILQSGKVYPEFEEIPPMSLDadTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNT-GSNDYINASLVsySVGSQ-H
.|. .| . .. .   ....||  ....... ||||.. .  |  .| .  |.| .|||||||.||.|.|..|.|....  ..||||||.|  .. ..  
rdallesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydllt

RSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKtKCHQYFPNDEEnakhvQFEQYRISTKFVEKSPSVITRCFTVHYmpTSEEREIMILQYID
| .|..||||. |. |||.|.|||... |.|||. .|.|. ||.||.|....     ....... .. ||. . ...| ..| .  ..|.|... .||..
rkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytg

WPDHGIPPDPQPFISYLRMVKSLRYKFDESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
|||||.||... ... |..|.. . . ... |..|||||||||.|.... ... | ....  .|... ...|| ||.. |||..|||||| ........
wpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
DSPc_SM00195 533-795 1.2e-80 266.0 In-house 5-262 (263) alignment 
Range on Protein: 533-795
Range on HMM: 5-262/263.0
EFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTN
|||..  .  . .|. .  . | .|||||.|.||.|.|..|...... ..|||||. .. .  .. ..||..||||. |. |||.|.||.|...|.|||.
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlte

IIENGKTKCHQYFPNDEenAKHVQFEQYRISTKFVEKSP-SVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFdeSIPI
  ||||.||..|.|...   .  .|..... .. ||| . ..|.| ... .  ..|.|..  .|| .|||||.| ........||.||. . .   | ||
eeengkekcdrywpees..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

VVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
||||||||||.|..|. |.. .  . .. .||.. . .|| ||...|||| ||.|.|..|..||
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 533-795 1.2e-80 266.0 In-house 5-262 (263) alignment 
Range on Protein: 533-795
Range on HMM: 5-262/263.0
EFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTN
|||..  .  . .|. .  . | .|||||.|.||.|.|..|...... ..|||||. .. .  .. ..||..||||. |. |||.|.||.|...|.|||.
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlte

IIENGKTKCHQYFPNDEenAKHVQFEQYRISTKFVEKSP-SVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFdeSIPI
  ||||.||..|.|...   .  .|..... .. ||| . ..|.| ... .  ..|.|..  .|| .|||||.| ........||.||. . .   | ||
eeengkekcdrywpees..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

VVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
||||||||||.|..|. |.. .  . .. .||.. . .|| ||...|||| ||.|.|..|..||
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0045450 (Phosphotyrosine protein) phosphatases II 529-796 2.2e-80 266.0 In-house 28-305 (307) alignment 
Range on Protein: 529-796
Range on HMM: 28-305/307.0
KVYPEFEEIPPMSL--DADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNT-GSNDYINASLVSY------SVGSQHRSYIVCQGPLEITCCDFWQMI
... |||.....      ..|... |.| .|||||||.||.|.|..|.. ... ...|||||| |        ..  . | .|..||||. |. |||.|.
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrml

WEQKTQLILMLTNIIENGKTKCHQYFPNDeenAKHVQFEQYRISTKFVEKSPSVITRCFTVHYM-PTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMV
|||....|.|||. .|.|. ||.||.|..     ......... .. .|. .... |...|... .|.|.|......|..|||||.||....... ...|
weqgvtvivmltelvelgrekcaqywPde...geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

KSLRYKFDESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEV---IDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
.. . . ... |..|||||||||.|.... ... .  . ...   .|. . ...|| ||.. ||...|||||| .......
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_PTPN3_pd Subfamily PTPN3 520-795 9.1e-80 262.6 In-house 7-275 (280) alignment 
Range on Protein: 520-795
Range on HMM: 7-275/280.0
HLEMILQSGKVYPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNtgsnDYINASLVSYSVGSQHR--SYIVCQGPLEITCCDFWQ
.|.  |.||.|  .||..     . ..||   | |..||||.||.||.. |..|. ...    |||||. |.  . |..    ||..||||. |. ||||
llkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWq

MIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENakhVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRM
|.||||..||.|||...|.|..|||||.|. |..   ... ....  .  ... |...| ....   |.|||.|. |||..|||||.| |.. |..... 
mvweqksslivmlttlverGrvkChqyWPetede...leygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefver

VKSLRYKfdESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
|..||    .. |.|||||||.||.|||.| ..     .. | . .   . ..| ||. |||| .||.|.   |.|  
vrklrsg..keePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
0043336 (Phosphotyrosine protein) phosphatases II 528-795 4.1e-79 261.2 In-house 20-277 (278) alignment 
Range on Protein: 528-795
Range on HMM: 20-277/278.0
GKVYPEFEEIPPMSLdADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVsySVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLI
 ... ||||.. . |  ..| .  | | .|||||||.||.|.|..|.. ..  ..||||||.|  .. .. | .|..||||. |. |||.|.||.... |
tllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwelgvtti

LMLTNIIENGKTKCHQYFPndeenAKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYkfDE
.|||.  |.|..||.||.|      .......... .. .|. . ...| ..|... ..|.|......|..|||||.|.........|..|.. .   |.
vmLtelvelgrvkcaqYwp.....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..ds

SIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
. |..|||||||||.|.... ..| | .. .  .|. . ...|| ||.. |||. |||||| ... |.
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPRD_pd Subfamily PTPRD 529-797 9.3e-79 260.5 In-house 24-283 (564) alignment 
Range on Protein: 529-797
Range on HMM: 24-283/564.0
KVYPEFEEIPPMsLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVS-YSvgsQHRSYIVCQGPLEITCCDFWQMIWEQKTQLI
|.  |...| .      ..| ..|.| .||||..|..|.|.|..|.. ... . |||||| .  |    ....||  ||||. |. |||.|.|||... |
kfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr...krkayIAtqgPlaetiedFWRmvweqnssti

LMLTNIIENGKTKCHQYFPNDeeNakHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRyKfDE
 |||.. |.||.|||.|.|..  .  . ..... .. .  |.   .. | |...   .|| ||.   ....|||||.|  ...... .| |..|. . ..
VmltkleEkgkvkchkYWPek..g..tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.pd

SIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
. ||||||||||||.|. .  |.. |     ...|| . ...|| || ..|||  || |....| .... 
agPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_PTPRB_pd Subfamily PTPRB 529-797 1.2e-77 255.9 In-house 26-287 (293) alignment 
Range on Protein: 529-797
Range on HMM: 26-287/293.0
KVYPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLIL
..  |.||.  .  |  ..| ...||..||||..|.||.|.|..|.. |.. ..|||||. ..    ...| .|..||||  |  |||.|.||.|.. |.
rfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgy..nsprefiatqGPlpetvddfWrmvwekkssiiv

MLTNIIENGKTKCHQYFPNDEENAkhvQFEQYRISTKFVEKSPSVITRCFTVHYmpTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDES
|||...|.||.||..|.|.|||.    .. . ... .  |.    ..| ....   ..|||... .... |||||.| .........|.|..   |  ..
mltqlvekgkvkCeeYWPadeepv...lyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektask

IPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
 ||||||||||||.|...  |.|... .  ...|| . .|.|| .|..||||  || |...........
rPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 531-798 1.9e-75 248.6 In-house 18-279 (281) alignment 
Range on Protein: 531-798
Range on HMM: 18-279/281.0
YPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILML
  |.|..  . .|  ..|  .. | .||||..|. |.. |....||... ..|||||. |.    .... ||..|||.  .. .||||.|||| ..| |.
ieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgy..kgekeyiatqgPvPaslvafWqmvweqkvsaivmv

TNIIENGKTKCHQYFPNDEEnakHVQFEQYRISTKFVEKSPSVITRCFTVhYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKfDESIP
|. ||.|| |||.|.|.|..   .... .......  |.... |.| |.. .. ..|.||.  |.|. |||||.| ... .... . |..|. | .. .|
treieagklkChrYWPddns...elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltek.ktkap

IVVHCSAGVGRSGVLVLSDMLTETY-DCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINNA
.|.||||||||.|. .  | | ..  .  | .|.|  .| || .|. .|||. ||.|.| ........ 
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
0040439 (Phosphotyrosine protein) phosphatases II 546-797 4.5e-75 247.8 In-house 3-248 (249) alignment 
Range on Protein: 546-797
Range on HMM: 3-248/249.0
TSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSVGSQHrsYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYF
.| .. |.| .||||.||.||.|.|..|.. ..   .||||||.....  ...  .|..||||. |. |||.|.||.. . |.|||.  |.|. ||.||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PNdeenAKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDESIPIVVHCSAGVGRSGVL
|.     .......... .. ||.......| ...... ..|.|... .||.||||||.||...........|.. . . ... |..|||||||||.|..
pl....ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

VLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
.. ... | ..    .|... .. || ||.. ||...|||||| ........
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
0045098 (Phosphotyrosine protein) phosphatases II 527-797 5.3e-75 247.6 In-house 6-274 (278) alignment 
Range on Protein: 527-797
Range on HMM: 6-274/278.0
SGKVYPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRlnpnkntgsnDYINASLVSYSvgsqHRSYIVCQGPLEITCCDFWQMIWEQKTQL
|.... |||......   . . .  . |..|||||||.||.|.|..          ||||||....     .. .|..||||. |. |||.|.||.... 
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitv

ILMLTNIIENGKTKCHQYFPNdeenAKHVQFEQYRISTKFVEKSPSVITRCFTVHYM----PTSEEREIMILQYIDWPDHGIPPDP--QPFISYLRMVKS
|.|||. .|.|. ||.||.|.     .......... .. .|  . ...| ..|..     .. |.|.. .|.|. |||||.|..|  ..|...|.....
ivmltelvelgrekcaqywpe....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefire

LRY-----------KFDESIPIVVHCSAGVGRSGVLVLSDMLTETYdcGEVIDIKSSLARLRLQRMH-LVQTLGQYRFLYTVIIKYINN
 .             .|.. |..|||||||||.|.||. ... | .  ....|. . .. || ||..  ||.|.|||||| ........
alkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 532-795 7.5e-73 240.1 In-house 25-279 (288) alignment 
Range on Protein: 532-795
Range on HMM: 25-279/288.0
PEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSysVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLT
 |.. ....  . ...||...||||||||..|.||...|..|.  ... ..|||||| .   .  ... ||  ||||  |  |||....|.||. |.|||
eeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyid..gekkkkkyiatqgPladtvndfWelvyenktstivmlt

NIIENGKTKCHQYFPNDEENAKHVQFEqyrISTKFVEKSPSVITRCFTVHymPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYkfDESIPI
...|.|||||..|.|..... .. ...   .  . ...  ....| . ..   . .|.||  .||  |||||.| . .|.. .||.||      ... ||
elveggktkCeeYWPdadkpknyGsvt...vtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanq..adtgpi

VVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
.|||||||||.|. .  |.| .. .  ..||. . .|.|| ||. ||||| || |.| |... |
ivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
Y_phosphatase Protein-tyrosine phosphatase 554-792 2e-72 238.8 Pfam-A 1-234 (235) alignment 
Range on Protein: 554-792
Range on HMM: 1-234/235.0
NAKKNRYKDIIPYEHNRIRLnpNKNTGSNDYINASLV-SYSvGsqHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENa
| ||||||||.||...|..|  ....|..|||||. | .|.    ....|..||||. |. |||.|.|..|...| |||.  |.|..||.||.|..||. 
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.e..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.

kHVQFEQYRISTK-FVE-KSPSVITRCFTVHYMPTS-EEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRykFDESIPIVVHCSAGVGRSGVLVLSD
  ........ .|  .. .. ....| ....   .. |.||.. |.| .|||||.| .|.......|.|.. .   ..| |.||||||||||.|..|. |
.sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvald

MLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVII
.| |  . .| .|... . .|| ||...||.| || ||| .|.
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 554-792 2e-72 238.8 In-house 1-234 (235) alignment 
Range on Protein: 554-792
Range on HMM: 1-234/235.0
NAKKNRYKDIIPYEHNRIRLnpNKNTGSNDYINASLV-SYSvGsqHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENa
| ||||||||.||...|..|  ....|..|||||. | .|.    ....|..||||. |. |||.|.|..|...| |||.  |.|..||.||.|..||. 
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.e..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.

kHVQFEQYRISTK-FVE-KSPSVITRCFTVHYMPTS-EEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRykFDESIPIVVHCSAGVGRSGVLVLSD
  ........ .|  .. .. ....| ....   .. |.||.. |.| .|||||.| .|.......|.|.. .   ..| |.||||||||||.|..|. |
.sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvald

MLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVII
.| |  . .| .|... . .|| ||...||.| || ||| .|.
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0042113 (Phosphotyrosine protein) phosphatases II 549-796 2.8e-72 238.3 In-house 4-244 (245) alignment 
Range on Protein: 549-796
Range on HMM: 4-244/245.0
GSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVsySVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNd
.. |.| .||||.||.||.|.|..|.| ..   .||||||.|  ..  . . .|..||||. |. |||.|.||.. . |.|||.  |.|. ||.||.|. 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

eenAKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKfDESIPIVVHCSAGVGRSGVLVLS
     ......... .. .|. .....| ..|......|.||.. ..|..|||||.|.... ... |..|.. . . |.. |..|||||||||.|.... 
...gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaa

DMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
... | ..    ... . ...|| ||.. |||..|||||| .......
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_PTPN13_pd Subfamily PTPN13 521-795 4.1e-72 237.7 In-house 4-269 (273) alignment 
Range on Protein: 521-795
Range on HMM: 4-269/273.0
LEMILQSGKVYPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNtgsndYINASLVSYSVGSQHRSYIVCQGPLEITCCDFWQMIW
|.  |....   ||.|.  .    ... | .  | .||||....||.. |..|. . .     ||||||.   || .. .||.|||||  |. |||||.|
lqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvw

EQKTQLILMLTNIIENGKTKCHQYFPNDEENAKHVQfEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKS
|||...| |.|.  |.|| |||.|.|. ...   |. ......   |.|  .   | ..|. . ..| ||.. |....|||||.|  ..... ... |..
eqkaeviamvtlekekgkvkchrywPesknkklkvs.nrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr

LRYkfdESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
|.    .. |||||||||.||||.|.  |.. .  .  . .|.|  . .|| ||  .|||  || | | .|.. .
lqt...dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN1_pd Subfamily PTPN1 534-793 5.3e-71 233.7 In-house 12-269 (290) alignment 
Range on Protein: 534-793
Range on HMM: 12-269/290.0
FEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNtgsnDYINASLVSysVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNI
...|   . | .|..  .| | ..|||.|. ||.| ||.|. ..|    ||||||||   .   .||||. ||||  |.. ||||.||||.. ..|| ..
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslve..leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkv

IENGKTKCHQYFPNDEEnAKHVQFEQYRISTKF--VEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDESIPI
.|....||.||.|..||  | ...|. ... |.   |..   . | . .. . | | |||.   |. ||| |.|  |. |...|  |..     ..  | 
vekeqikcaqywPqgee.ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpa

VVHCSAGVGRSGVLVLSDML-TETYDCGE--VIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIK
|.|||||.|||| ..| | .  .  . ..   .|||  |  || .|. |.||  | || |. |..
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN6_pd Subfamily PTPN6 532-798 6.8e-70 230.5 In-house 30-300 (306) alignment 
Range on Protein: 532-798
Range on HMM: 30-300/306.0
PEFEEIPPM--SLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNpNKNTGSNDYINASLVSYSVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILM
 ||||.  .  .   . . |. | |..||||| |.|..|.|. |. ....  .|||||. .. .| ....|||  || || |  |||.|.|......|.|
eefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivm

LTNIIENGKTKCHQYFPNDEENAKhvqFEQYRISTKFVEKSPSVITRCFTV-HYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFD--
.|. .| || || .|.|. ||. .   . ......   ..  . | | ..| .    .||||.. ... .|||||.| ||. ....|. |.. . ..   
ttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea

ESIPIVVHCSAGVGRSGVLVLSDMLTETY---DCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINNA
|. |||||||||.|| | ... |.|...     .   |||...   .| ||  ||||  ||.|.|..| |||.. 
eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 518-797 6.1e-69 227.5 In-house 8-282 (318) alignment 
Range on Protein: 518-797
Range on HMM: 8-282/318.0
AQHLEMILQSGKVY--PEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDF
..|.. . .||...   |.|.. . .  . .    .|||..|||| .|..|.| |..|.. ... . |||||. .      ....|| .|.||  |. ||
eshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGy..rrkkayiaaqaPlpetieDf

WQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEEnakhVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYL
|.|.|||....|.|||.. |.||.|.|.|.|...      .... ..  |   .. . . | |.|.   ..|.|..   .| .|||.|.| ..  ... .
WrmvWeqnsavivmltqeeergkakvhryWPskgs....rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RMVKSLRYKFDEsIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
| |..   | ..  |||||||||||| || .  |.| |     ...|.     .|| ||  .|||  || |.|.|...... 
rqvskaqqksga.gpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
0037934 (Phosphotyrosine protein) phosphatases II 548-795 7.5e-69 227.2 In-house 4-242 (243) alignment 
Range on Protein: 548-795
Range on HMM: 4-242/243.0
AGSNPVNAKKNRYKDIIPYEHNRIRLnpnknTGsNDYINASLVSYSvgsqhRSYIVCQGPLEITCCD----FWQMIWEQKTQLILMLTNIIENGKTKCHQ
 .. |.| .||||.||.||.|.|..|      | .|||||.|.        . .|..||||. |..|    ||.|.||.... |.|||. .|.|. ||.|
iallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvt.....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YFPndeenA-KhvQFEQYRISTKFVEKSPSVITRCFTVHYMP-TSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYK------FDESIPIVVHC
|.|       .  ....... .. .|  .... | ... . . . ..|... ..|. |||||.|..|......|..|..   .       |.. |..|||
ywp.....gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC

SAGVGRSGVLVLSDMLTETYdcGevIDIKSSLARLRLQRMH-LVQTLGQYRFLYTVIIKYI
||||||.|.|.. ... . .  |  .|. . ...|| ||..  |||..|||||| ......
saGvgRtGtliaaylmllll..g..vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 545-797 1.3e-68 226.0 In-house 31-279 (290) alignment 
Range on Protein: 545-797
Range on HMM: 31-279/290.0
DTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSVGsqHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQY
 |.||....| ||||||||.||...|. |. ....  .|||||...  . |  . .||  ||||  |  |||.||||.......|. ...|.||.||..|
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg..kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerY

FPNDEEnaKHVQFEQYRISTKFVEKSP-SVITRCFTVHYMptSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYkfDESIPIVVHCSAGVGRSG
.|.  |  ....|........  ..     . |...|.    .|.|..  ..| .|||||.|  ... .. ...|..|.   .|..|.|||||||||| |
Wpeege..eelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtG

VLVLSDMLTETYDCGEV---IDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
...  |.  |    . .   .|. . ...|| ||  ||||  ||...|  .......
tiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 531-796 1.1e-67 223.4 In-house 33-291 (298) alignment 
Range on Protein: 531-796
Range on HMM: 33-291/298.0
YPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSVGSQhrSYIVCQGPLEITCCDFWQMIWEQKTQLILML
. .....     .. ......| | ||||| |||.... |..|. ...    |||||| ..   |..  ..|..|.||. |  |||.|..|.. . | ||
fqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigtiVml

TNIIENGKTKCHQYFPNDEENakhvQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSlRYKFDESIP
||. | .|||.|.|.|.....    .... ..| .  |.   .|.| ..|.   ...|||.  |... |||.|.|   .  . .|| |.    .     |
tnleeldktkyhkywPdegke....tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkp

IVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
..|.|||||||||  .  | . |     .|.|.   . .|| .|...|||  || |.|........
vivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPRA_pd Subfamily PTPRA 530-794 2.1e-65 215.8 In-house 34-294 (330) alignment 
Range on Protein: 530-794
Range on HMM: 34-294/330.0
VYPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILM
.  ||. .|  ...|   . |.  | .|||. .|.||...|. |.. . . . |||||| .      .  ..| .|||.| |  |||.||||||.. |.|
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGy..kekdkfiaaqGPkeetvedfwrmiweqksativm

LTNIIENGKTKCHQYFPNDEenakHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSE----EREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKF
||.. |  ..||.||.|..      | . . |.. . .. . ..  | | |. .| .     .| .  . .  ||| |.| .|.  ...|. ||.|. . 
ltelkerkeekcaqywPdeG....lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqs

DEsiPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKY
 .  ||||||||||||.| ..  | . |   . ...|.   . |||||| ..|||. || |.| |. .|
ag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 533-796 1.3e-63 210.0 In-house 27-284 (305) alignment 
Range on Protein: 533-796
Range on HMM: 27-284/305.0
EFEEIPPMslDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTN
......    .  .  |.. .|..|||.|.|......||.|....... .|||||| |     ... .||| ||||. |  |||..|.| |.. |.|||.
qykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgy..krkkkyivaqgPlkntvadfWrliveekvstivmltk

IIENGKTKCHQYFPNDEENakHVQFEQYRISTKFVEKSPSVITRCFTVHY-MPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSlRYKFDESIPI
..|.|| ||.||.|. . .  ...|... .  |  .. .  |.| ...      .|.| .. .|  ||||||.|  .  ..| .. |.  ..| |.  |.
lveggkdkCrqYWpeskte..kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqk.dqkkdkgvpl

VVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
.|||||||||.|| .  |.  |     ||.|.   | .|| .|| .|||| || ||. .. ..|.
lVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPN23_pd Subfamily PTPN23 544-797 4.3e-63 207.8 In-house 33-282 (288) alignment 
Range on Protein: 544-797
Range on HMM: 33-282/288.0
ADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNpnknTGSNDYINASLVSySVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQ
 ..|     ....|||..||.||.|||. |.     . .|||||| |  .. ..  ..|. |.||. |  |||.|..|||...| ||..  | ||.|...
rkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvk.dlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdr

YFPNDEENAkhVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSL--RYKFDESIPIVVHCSAGVGR
|.|.|....  |.|...... | |.... .. | ....  .... .... ||.  ||..|.|  |. .. .|  |.|     .    .|.||||||||||
YwPedkget..vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgR

SGVLVL-SDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
.||. |    ..|..    ..||   . ||| || . ||.  |..|.| ........
tgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_PTPN9_pd Subfamily PTPN9 530-797 3.7e-62 205.0 In-house 18-292 (297) alignment 
Range on Protein: 530-797
Range on HMM: 18-292/297.0
VYPEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILM
.. |..||  ..      |   ..| .||||.|.. |.. |. |.  ...   |||||. |      |....|  ||||. |. |||.|.|||..  |.|
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGy..kqkkafiatqGplkktvsdfWrmvWeqevlvivm

LTNIIENGKTKCHQYFPNDEENAkhVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDE--
 | ..|.|. || ||.|..||..   .| ....|.  ||..    .| .... . |.|.|...  |.. |||.|.| . . ..  |..|.. . .. .  
ttrvvergrlkcgqyWpleeess..aefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkel

---------SIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
           |||||||||.||.| ..  |.  .  .  ...|.  .. .|| || . .||  || | |  .. |  .
gdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Ptp69D_pd Subfamily Ptp69D 532-796 9.9e-62 203.8 In-house 26-287 (307) alignment 
Range on Protein: 532-796
Range on HMM: 26-287/307.0
PEFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVS-YsvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILML
 |.|...    | .|... .  || ||||.||......|..|.. . . . |||||| .  |    .....|. |.|.| |  |||.||.||. .|| ||
keyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgy...kekkkfiaaqdPveatigDfWRmiaeqevtlivml

TNIIENGKTKCHQYFPNDeenaKHVQFEQYRISTKFVEKSPSVITRCFTVHYMP-----TSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLrYKF
.|. |  . ||..|.|..    . ||...  . .   || .  | | . |  .        ..|...  .|  |.|  .|  ..  . ....|..| ||.
snlteknrkkcakYWpie....devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel.ykl

DeSIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
.   ||||||||||||||..|  |.| .     . .||      || ||  ||| | || |||  ...|..
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 554-797 1.5e-60 199.4 In-house 20-266 (270) alignment 
Range on Protein: 554-797
Range on HMM: 20-266/270.0
NAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSySVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENAK
..| |||.||.|  . |.||.. ...    ||||  |   . .....||  .|||. |  .||.||||.|.. |.|.|.. |.|..|| .|.|.. ..  
gkklnRyadiLPsPatRvrleeleedsataYinAnyvr.GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

HVQFEQYRISTKFVEKSPSVITRCFTVHymPTSEEREIMILQYIDWPDHGIPPDPQ------PFISYLRMVKSLRYKFDESIPIVVHCSAGVGRSGVLVL
.... . .. .   ||.   |..  ...   ..|||...  .| .|||||.|....        .. || |.  . ..|.. |..|||||||||.|.|..
kledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

SDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
 |. ... .  . .|. . ...|| .|| |||.  ||.||| ....|.. 
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 532-796 5.5e-60 198.1 In-house 27-284 (319) alignment 
Range on Protein: 532-796
Range on HMM: 27-284/319.0
PEFEEIPPMSLDaDTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVS-YsvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILML
 ||...   . | ...  |.. | |||||..|..|.. |. | . ... . |||||| .  |    ... .|  |.||| |  |||.|.||...  ..||
kefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgy...qerekfiatqaPlentiedfWrmvWeeessivvml

TNIIENGKTKCHQYFPNDEenakHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTS-EEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFdESI
|.. |..| |...|.|. .    .... .. .  .  |.   .| | ....   .  | ||..  || .||||..| . .  .  |. ..  | |  .| 
tklveklkvklkkywpeen....feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt.qsg

PIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
|||||||||||| |  .  |.  |     .|.|. |   |||.||  .||.  ||.|.| .......
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 547-796 1.1e-59 196.6 In-house 2-243 (250) alignment 
Range on Protein: 547-796
Range on HMM: 2-243/250.0
SAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSVGSqhRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTkCHQYFP
| . .| | .|||| |||.... |. |...|     |||||| .    ..  ...|. ||||. |  |||.|..|.|.. |.||||. |..|| .|||.|
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP

NDEENakhvQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDeSIPIVVHCSAGVGRSGVLV
 .. .    .. . ..| .  |.   ...| . .     ..|| .  |... ||| |.|   .  . .|. |.. . . . . |..|.|||||||||  .
vekae....kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqag.naPvivqCsaGvgrsGafi

LSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
  | . |     .|.|.   . .|| .|.| |..| || |.|..|.|...
aidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 531-797 1.1e-58 193.5 In-house 8-270 (274) alignment 
Range on Protein: 531-797
Range on HMM: 8-270/274.0
YPEFEEIPpMSLdaDTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGS-NDYINASLVSySVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILM
. || |.| .    |.   . . ...|||||.|.| |. |. |...... .  .||||  .    . ... |.  ||||  |  |||.||.....|.|.|
ekeflelP.lnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyik.GydeeskayvatqGPlpntvadfWrmiyqeevqvivm

LTNIIENGKTKCHQYFPNDEENAKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTseEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDES-
||.. |. ..||..|||..|.   . ....  | .. . .      | ....|.    ||...   | |||||  | |...... .. |.. | . ..  
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakl

IPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
 |.|||||||.|| |. .  ..     .  .|.|. .  . |||.|  .|||  ||.... ....| ..
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPRG_pd Subfamily PTPRG 533-796 1.2e-58 193.7 In-house 24-288 (563) alignment 
Range on Protein: 533-796
Range on HMM: 24-288/563.0
EFEEIPP--MSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSN-DYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILM
|||..    .| | |... ..| | .|||| .|..|.. |..|.|  .. .. |||||. .      ... .|. ||||. |. |||.|||||....| |
efealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGy..qkskafiatqgplkdtfddFWrmiWeqnvaiivm

LTNIIENGKTKCHQYFPNDE-ENAKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPT-SEEREIMILQYIDWPDHGIPPDPQPFISYLRmvKSLRYKFDE
.||. |.|. ||..|.|.|| |. ...|  . .  .. .  . ... . . ..      .|....  .| .||||| |  . | ... .  || . . .|
itnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk..kssaankae

SIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
  ||||||||||||.|...  | |..     .....   | ..|.|| .||||  || ||. .... |.
aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_PTPRK_pd Subfamily PTPRK 550-793 1.7e-58 193.0 In-house 39-275 (314) alignment 
Range on Protein: 550-793
Range on HMM: 39-275/314.0
SNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVsySVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDE
 .  | .|||..||..|.. |..| . ..  |.|||||.|.      . . .|| ||||. |  |||........  |.|||...|.|. || .|.|.| 
kkdenreknrsgdilaydrsrvflitidgdpssdyinaali..dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

ENAKHVQFEQyrISTkfvEKSPSVITRCFTVHY--MPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKfdESIPIVVHCSAGVGRSGVLVL
|  .... |   ..|   |    ...| |.|.    . .| ||.  .|.. ||||..|   . .....| ||. . .  |  .|||||||| ||.|. . 
evygdikvel..vet...ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfia

SDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIK
 |.. .  .. .|.|.      || ... .|.|  ||.|.| ||. 
idivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 533-796 1.1e-57 190.3 In-house 23-277 (515) alignment 
Range on Protein: 533-796
Range on HMM: 23-277/515.0
EFEEIPPMSLDADTSAGsNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSySVgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTN
|| ..|   .  .| |  . .| ||||||.|.||. .|..|.  ..   .||.||| .  |.    ..||  |||.. .  |||........  | |.|.
efhdlpgpniypqtvaq.eeinfkknryknilPydsvrvklevindnPhsdyfnasyip.sf.dndkayiasqgPnkasvddfWrlvlqenvttiamvtk

IIENGKTKCHQYFPNDeeNAKHVQFEQYRISTKFVEKSPSVITRCFTVhyMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDesIPIV
  |. | || .|.|.    .. |.| ......  .|     | | .||  .  .. | .   .. .|||.|.|.. . .. ... ||. . ..    |..
lkegdkikcgkyWPdk..pgdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpli

VHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
.|||||||| ||..  |        ....|.   .  .| .|..||||  || |.| ..  .. 
ihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 531-793 1.4e-57 190.4 In-house 37-289 (319) alignment 
Range on Protein: 531-793
Range on HMM: 37-289/319.0
YPEFEEIPPMSLDADTSAGSN-PVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSysvGSQH-RSYIVCQGPLEITCCDFWQMIWEQKTQLIL
  ||  .. .. .  . . .| . |  |||. .|.....|...|..       |||||| |.   | |.   || .||||. |  |||.||||...  |.
evefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvt...GyqrkdkyiaaqGPldntladfWrmiweyncstiv

MLTniiengKTKCHQYFPNDEEnakhVQFEQYRISTKFVEKSPSVITRCFTVHY-MPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDE
.||      | || ||.|.. .    .. |.. .. . ||..   . | . .       . |.|    .  |||.| |  | ...  .. |. |. | ..
llt......kdkcsqywplkiv....ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh

SIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIK
  .|||||||||||.|| .  |.| .  .  . .|.   .  || || .||| | || |.|. ...
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 533-796 1.8e-57 189.6 In-house 24-278 (315) alignment 
Range on Protein: 533-796
Range on HMM: 24-278/315.0
EFEEIPPMSLDADTsAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSySVgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTN
|| ..|       . .. ...| ||||||.|.|....|..|.   ..  .|||||| .  ||  . ..||  ||||. .  |||.|....|.  | |.|.
efhdlpdPdiyrqr.varetinfkknryknilPldsarvkleviddsPdsdyinasyik.sv.dddkayiasqgPlkasvddfwrmvlqekvttivmvtk

IIENGKTKCHQYFPNDEenAKHVQFEQYRISTKFVEKSPSVITRCFtvHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLryKFDESIPIV
  |. | || ||.|. .  |. |.| ......  .|     ..| .      . | | .   |. .|||.|.. .   .. ... ||.   .  .  ...
kqegdkikcrqywPdrk..adsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsll

VHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
|||||||||.||..  |   .    ....|.   .  || .|..||||  .| |.| .. ... 
vhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 545-793 9.6e-57 187.6 In-house 15-253 (284) alignment 
Range on Protein: 545-793
Range on HMM: 15-253/284.0
DTSAGSN-PVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSysvGSQH-RSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTniiengKTKCH
 . . .| . |  |||. .|.....|...|..       |||||| ..   | |.   || .||||. |  |||.||||...  |..||      | || 
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfit...GyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcs

QYFPNDEEnakhVQFEQYRISTKFVEKSPSVITRCFTVHY-MPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDESIPIVVHCSAGVGR
||.|.. .    .. |..... . ||.|   . | . .       . |.|    .  |||.| |  | ...  .. |. |. | ..  .|||||||||||
qywplkiv....ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

SGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIK
.|| .  |.| .  .  . .|.   .  || || .||| | || |.|. ...
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 543-797 2.5e-55 182.4 In-house 35-285 (290) alignment 
Range on Protein: 543-797
Range on HMM: 35-285/290.0
DADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNT--GSNDYINASLVS-YsvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKT
.  .  |  . | ..||...|..|. ||| |.|  .    .|.||||. .  |   .....||. |||.. |  |||..||..|.  |.|||||||.||.
ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgy...kekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkv

KCHQYFPNDeeNAKHvqFEQYRISTKFVEKSPSVITRCFTVHYMPT-SEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDeSIPIVVHCSAG
||.||.|.   ..|.  .....|     |.  . |.| . |. . .  ...... .|   |...|  ..||  .. .. .   ..|     .||||||..
kCqqYWpds..dtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHCSdt

VGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
||||.|..  ..  .      |||. . | ..| |.. .|||  ||.........|...
vgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPRN_pd Subfamily PTPRN 534-796 1.3e-54 180.0 In-house 35-293 (297) alignment 
Range on Protein: 534-796
Range on HMM: 35-293/297.0
FEEIPPMSLDADTS-AGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVsYSVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTN
.| .     .  |. ..... |.||||.|...||.|.|..|. . .. ..|||||| . .    .. .|| .||||  | .|||||.||| . .|..||.
wealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasai.ldhdprapayiatqgplastvadfwqmvweqGvvvivnltr

IIENGKTKCHQYFPNDEENAKHVqFEQYRISTKFVekSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVK-SLRYkfdESIPI
. |.| ..|..|.|.. ..  |. .|   .| .    .   . | | .  . ||| | .  . .. ||..|.|. ..... . | |  | |     | ||
leeegvkqckrywpdeGsevyhi.yevhlvsehiw..cddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG...rscpi

VVHCSAGVGRSGVLVLSDMLTETYDCG-EVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
|||||.|.||.|| .| |.. .    |   ||| ..|  || || .||.|  |..| .|.... .|
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevn
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 533-793 4.7e-51 168.6 In-house 29-277 (315) alignment 
Range on Protein: 533-793
Range on HMM: 29-277/315.0
EFEEIPPMSLDADTSAgSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTN
..| ||   |     |  .  | .|||| .||.|.. |..|   .|    ||.||...     ...| || .|||.  .  |||....|..   |.||||
dyesipggqlhpldva.kkienkqknryiniiaydksrvqlpllendphsdyvnanfidGy..nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltn

IIENGKTKCHQYFPNDeenakHVQFEQYRISTKFVEKSPSVITRCFTVHYmpTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSlrYKFDESIPIV
..|. | |. .|.|..     .| . .. .. |  |.   .  | ..| .   .. ||.. |.|  ||| |.|    |.. . | ||   .. ..  .||
lvegekrkaekywpdk.....kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkq..hhtnsvgaiv

VHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIK
|||||||||.| ..  | . .  .  ..||.   . ..| .|...||.. ||.|.| ....
vhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 533-795 9.2e-51 167.7 In-house 31-284 (297) alignment 
Range on Protein: 533-795
Range on HMM: 31-284/297.0
EFEEIPPMSLDADTSAgSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSysvGSQHrSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTN
||  .|   . ..| |  . || .|.|||.|.||. .|..|.   .  . ||.||| |    | .|  .|  | | . |  |||.|....... |.||..
eflclpeaniqpqtva.ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvk...gnkh.rlittqmPmkatvadfWamvldeqvstivmlnd

IIENGKtKCHQYFPNDEENAkhvqFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPP--DPQPFISYLRMVKSLRYKFDESiP
  |. | || .|....  ..    | .  . .. |..    | | ..|    .  .| .   |...|||. ..   . . .. ..  |.    .  |. |
dnerdk.kcaryWsdkgvtt....fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.P

IVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
..|||.||||| |||.  |         . .||   . .|| .|..||||  ||.|.| ......
llvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 532-795 2e-50 166.8 In-house 27-288 (325) alignment 
Range on Protein: 532-795
Range on HMM: 27-288/325.0
PEFEEIPPMSLDADTSAGsNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSVGsqHRSYIVCQGPLEITCCDFWQMIWEQKTQlILMLT
 ||. .|.    | . |.  | | .|||.|........|. |.  |. .| |||||| .   ..     .. .| ||  |  |.|... . ..  .....
hefgllpsddgiakkvam.kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkk..kdvflaaqaPltatindlWrlvldWrcs.vvvvl

NIIENGKTKCHQYFPNDeeNAKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDE----
|....|| .| .|.|..   .| ..|   ... . .|.    . | . |  .   | | .  .|.  |.| | .  |  .||.|..|| .  .       
neldlgkdrcavywpke..mgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantka

SIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
| ||.|||||||||.||..    . .       .||  .. .|| .|  .|.|  || ..|. .....
stpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 552-797 3.1e-50 165.8 In-house 45-280 (287) alignment 
Range on Protein: 552-797
Range on HMM: 45-280/287.0
PVNAKKNRYKDIIPYEHNRIRLNpnknTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEEn
. | .|||...|.... .|. |.       .|||||. .     .... .|....|.  |  .||..|.... . |.||..  || . .|.||.|...  
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgy..kekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.

akhVQFEQYRISTKFVEKSPSVITRCFTVHYMP-TSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDEsIPIVVHCSAGVGRSGVLVLSDM
   | . .|.|.    |.. ..| | . |.    ........  |. .|...|  ..||  .  .      ..|  .  .||||||..||||....  ..
...vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgn.tsivvhCsdtvGrsamfcaaat

LTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
  .  .   |||. . | . | |... |||  ||.|.. ....|.. 
tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 549-796 8.3e-50 164.2 In-house 33-278 (287) alignment 
Range on Protein: 549-796
Range on HMM: 33-278/287.0
GSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSnDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPND
  .  ..||||| |..|....|. |  . . || |||||  |.     .. ..|..|||.  |  |||....|...  ....|  .|... ||..|.|. 
aeelaavkknryadvlPiddtrvllsaegelGs.dyinanyvasy..tddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

eEnaKHVQFEQYRIST-KFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVK---SLRYKFDESIPIVVHCSAGVGRSGV
 |  . ..   | .   ..  |.|   .|.. .  . | | | .  |....|||....|    .| .   ||    |. . .|  |.|||...|.||||.
.e..vPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGi

LVLSDMLT-ETYDCGEViDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
|.   .|     | |.| |.   ..||| .|  |||.  |.|.||  .. | .
llatlvlvsrledlGrv.dvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 543-792 1.4e-48 160.2 In-house 22-263 (283) alignment 
Range on Protein: 543-792
Range on HMM: 22-263/283.0
DADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNtgsnDYINASLVSYS-VGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKC
| |.   |.  | .|||...|.|.. .|..|... .    |||||. .  |    | . ||..|.||. |  |||.|....|   |.|||.. |. . ||
dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

HQYFPNDEenakHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSE-EREIMILQYIDWpdhgIPPDPQPFISYL---RMVKSLRYKFDESiPIVVHCSA
 ||.|..      ... .. .. .    | | | . .....  ... .  .   |.|||    .  ..|. |  |     |.||. .  .. |||||||.
sqyWPkrG....sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkg.PivvhCst

GVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVII
|.||..|..      .      |.|. . .  .| ||| .||||.||........
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 542-796 9.7e-48 157.4 In-house 28-294 (301) alignment 
Range on Protein: 542-796
Range on HMM: 28-294/301.0
LDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKN--TGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKT
 |  .. | .  |.. ||.|.| .|..||| |.|..|  . ...||||| ..    |... .|. |||.. |  |||..||..|.. |.|.||  |. |.
edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgy..sekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtks

KCHQYFPNDEENAKH-VQFEQYRIS----TKFVEKSP----------SVITRCFTVHYMPtsEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYK
||.||.|| |.. .. ..|.   ..      || ..           . | | | |.     . .... || .|||..|. ..|.  .  .  |   . |
kceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqk

FDESiPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
 . . |.|||||..|.|||| .  ..  |      |.|.     ..| ...  |.|| || ..| || .|..
iggg.pvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 554-792 6e-47 154.8 In-house 3-236 (237) alignment 
Range on Protein: 554-792
Range on HMM: 3-236/237.0
NAKKNRYKDIIPYEHNRIRLNPNknTGSNDYINASLVSYSVGSqHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENAk
|  |||| .|. |.|.|. |. .   .. |||||. .    |.  ..|| .||||| .| |||||.|..|  .|.||| .||. . |||.|.|. .. | 
nkiknrygnivaydhsrvvlkga..gsgsdyinatylkgfdgt.pkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa.

hvQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEE-REIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDESIPIVVHCSAGVGRSGVLVLSDMLT
   . .. .| |  |.      |.... .  | .| | |   |.  |||.|.|     .. . . .     .  || | ..||||||||.|.... | . 
..aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

ETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVII
      .|.||   .  .  .| ...||  || |.. .|.
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0051429 (Phosphotyrosine protein) phosphatases II 582-797 1.4e-45 151.4 In-house 4-227 (272) alignment 
Range on Protein: 582-797
Range on HMM: 4-227/272.0
NDYINASLVSYSvgS--Q-HRSYIVCQGPLEITCCDFWQMiWEQKTQLILMLTNIIENGKTKCHQYFP--------NDEENAKHVQFEQYRISTKFVEKS
..||||. |.          . .. ..|||..|. |||.. .|..   |..|..  | |. ||..| |          .. |  . . ..|. . ..|  
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PSVITRCFTVHYM-PTSEEREIMILQYIDWPDHGIPPDPqpFISYLRMVKSlrykfdeSIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVID-------
. .| | ...... ...| ||.|.|.|.||||||.|...  ... |... .       . |..||||||..|.|..|. ..| .  .   ..|       
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
 .   ...|| ||.. ||| .||.||| ........
yleeaveelraqrpgavqteeqylflyeallellrs
0041856 (Phosphotyrosine protein) phosphatases II 554-795 2.7e-45 149.5 In-house 1-171 (182) alignment 
Range on Protein: 554-795
Range on HMM: 1-171/182.0
NAKKNRYKDIIPYEHNRirlnpnkntgSNDYINASLVSYSVGSQHrsYIVCQGPLEITCCDFWQMIWEQKTQLILMLTniiengktkCHQYFPNDEenak
| .||||.||.||.|.|           .|||||.|.  |  ...  .|..||||  |. ||..|..|.. ..|..||         ...|.|...    
nldknrysdilpydhsr..........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywpell....

hvqfeqyristkfvekspsvitrcftvhymptseEREIMILQYIDWPDHGIPPdPQPFISYLRMVKSlrykfdESIPIVVHCSAGVGRSGVLVLSDMLTE
                                  ||... ..|. |||||.|. .. .......|..      |. |..|||||||||.|.||. ... .
..................................erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkk

TydcGevIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
    |  ... . .. .| .|.. |.|. ||.||. ..  ..
l...g..vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 553-800 6.1e-45 148.3 In-house 47-292 (305) alignment 
Range on Protein: 553-800
Range on HMM: 47-292/305.0
VNAKKNRYKDIIPYEHNRIRLNPNKntgSNDYINASLVSysVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENA
 .|.||||||.   ..||..|..       .|| |  ||    .. . .| .| ||| || ||| | ...| . |.|| |..| |  ||..||. .... 
qeagknrykdvgcldnnrvklegpw...pheyihanyvs..tptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

KHVQFEQYRIS--------TKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRykfdesIPIVVHCSAGVGRSGV
 . . .. .||         ||.... ...|.   |   | .. | .    .||||| |.|.  .  .  |   ....       |||||||||.||.| 
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk......gpivvhcsagigrtgs

LVLSDMLTETYDCGEVIDI-KSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINNARL
.|. . . .    |..|.  .  | ..| ||   .||  || |.. ||..|... .|
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 551-791 1.7e-44 146.8 In-house 5-237 (239) alignment 
Range on Protein: 551-791
Range on HMM: 5-237/239.0
NPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSVGSQhRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDee
. ||  |||| .|. |.|.|. |.   |   .|||||| .    ||  ..||  || .||.. |||.|.|...  .|.||| .||  | |||||.|.   
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp.kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..

NAKhvqFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRmvKSLRYKFDESIPIVVHCSAGVGRSGVLVLSDM
 .|   . . |.. .  |     | | | .  .  .||| .   ..  |||.|.|      .   |  |  .  .  . | |.||||||||.| ... | 
tsk...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr..kitkdslpgarpwvihcsagvgrtgaflvida

LTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVI
.       . .||   .  .| .| |.|||  || |..  .
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 552-791 1.9e-44 146.6 In-house 5-236 (239) alignment 
Range on Protein: 552-791
Range on HMM: 5-236/239.0
PVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSVGSQhRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDeeN
 ||  |||| .|. |.|.|. |.   |   .|||||| .    ||  ..||  || .||.. |||.|.|...  .|.||| .||  | |||||.|.    
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp.kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..t

AKhvqFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRmvKSLRYKFDESIPIVVHCSAGVGRSGVLVLSDML
.|   . . |.. .  |     | | | .  .  .||| .   ..  |||.|.|      .   |  |  .  .  . | |.||||||||.| ... | .
sk...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrr..kitkdslpgarpwvihcsagvgrtgaflvidam

TETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVI
       . .||   .  .| .| |.|||  || |..  .
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_CG7180_pd Subfamily CG7180 549-795 2.8e-44 145.9 In-house 37-290 (296) alignment 
Range on Protein: 549-795
Range on HMM: 37-290/296.0
GSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSVgsQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKtKCHQYFPND
| .  | .|||. ...||..||. |.  .   ..|||||. |   .  ... ||| ..| . |  .||......... . .||.  .  | ....|.||.
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl..kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

EenakHVQFEQYRISTKFVEKSPSVITRCFTVHYM----------PTSEEREIMILQYIDWPD-HGIPPDPQPFISYLRMVKSLRYKF---DESIPIVVH
     . |. .  . .  ... . . .| | .  .           . |.| .. .|.  |.  . .|   . .|  .|.|...| |    .|  |.||.
s....keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
.| |..|||| .  |.  |  .  | .|.   . .|| .| .||..  .|...| |. ...
ssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0049772 (Phosphotyrosine protein) phosphatases II 549-796 4.5e-44 146.8 In-house 41-281 (314) alignment 
Range on Protein: 549-796
Range on HMM: 41-281/314.0
GSNPVNAKKNRYKDIIPYEhNRIRLnPNKNTGSNDYINASLVSYSvgsqhRSYIVCQGPLEITCCDF----------WQMI--WEQKTQLILM-------
.. ..| .||||.||.|.. || .| |. .  . |||||| |.       ...|..|||||||..||          |.|.  .....  | |       
adlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LTNIIENGktkcHQYFPNDEENAKhvqfeqyristkfvekspsvitrcfTVHYMPTSEEREIMILQYIDWPDhGIPPDPQPFISYL
              |... .||     .. . | |. |                         ...| |   ||... . .|..|| | .|... | . |
delsrLdaAlgKtpllildgng....neptaadlellk.........................eelydpelferlgikylripvpD.gsaplledfdefl

RMVKSLrykfDESIPIVVHCSAGVGRSGVLVLSDMLTETYDcgevIDIKSSLARLRLQRM-----HLVQTLGQYRFLYTVIIKYIN
......    |.  |..|||.||.||.|..|. ..|   ..    ....  |...||.|.     .....| || | . .. .|..
efieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk
0036282 (Phosphotyrosine protein) phosphatases II 582-788 9.3e-43 141.3 In-house 2-163 (174) alignment 
Range on Protein: 582-788
Range on HMM: 2-163/174.0
NDYINASLVSYSVGSQhrSYIVCQGPLEitccdFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNdeenakhvqfeqyristkfvekspsvitrcftvh
.|||||| .. |. .    .|..||||.     ||.|..|.. . ..||.. .|.|..||..|.|                                   
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................

yMPTSEEREIMILQYIDWPDHGIPPDPQpFISYLRMVKSLRYKfDESIPIVVHCSAGVGRSGVLVLSDMLTETYDcGEVIDIKSSLARLRLQRMHLVQTL
 .....||... ..|. ||||| |.... ... .. |.. . . |.. |..|||||||||.|.||. ...        ..|. . ...|||||.. ||| 
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

GQYRFLY
.||||||
sQyrfly
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 533-795 1.4e-42 140.6 In-house 25-279 (439) alignment 
Range on Protein: 533-795
Range on HMM: 25-279/439.0
EFEEIPPMSLD--ADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILML
.||.|  .| |  ...|  ..  .  ||||||. ...| |. |.         ||||  .      . . || .||| . |. |||....|.||  |.||
ifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGy..yddklyiatqgpkkettddfwrlviekktvtivml

TNIIENGKtkchqYFPNDEENAkhvqFEQYRISTKFVEKSPSVITRCFTVHYMP--TSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKfDES
||..|  |     |.| |.|      . .  . .    . |  . | | |      |  || .. ..|| |||. .| .    . .|| ..|   | .| 
tnlvesyk.....ywpsdaevc....ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eey

IPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
 |.||||||||||.| ..  |.  |     . .|||  .  || || ..||.| || |.|  ... |
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
0043147 (Phosphotyrosine protein) phosphatases II 580-788 1.7e-40 133.9 In-house 3-154 (172) alignment 
Range on Protein: 580-788
Range on HMM: 3-154/172.0
GSNDYINASLVSYSVgsQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIiengktkchqyfpndeenakhvqfeqyristkfvekspsvitrcft
...||||||......    ...|..||||  |. |||.|..|.. ..|..||.                                               
egsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel..............................................

vHYMPTSEEREIMILQYIDWPDHGIPpDPQPFISYLRMVKSLRyKFDESIPIVVHCSAGVGRSGVLVLSDMLTetydcgEVIDIKSSLARLRLQRMHLVQ
  | |. .||... ..|. ||||| | ... ... |. ...|    ... |..|||||||||.|.||. ...       . ...   .| .| .|.. ||
.lydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

TLGQYRFLY
. .||||||
npsqyrfly
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 550-795 2.9e-40 133.2 In-house 37-277 (307) alignment 
Range on Protein: 550-795
Range on HMM: 37-277/307.0
SNPVNAKKNRYKDIIPYEHNRIRLNpnKNTGSNDYINASLVSYSVgsQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDE
.   |..||||.|.   ...|| ..   .  . ||| |  .  ..  . . .|..||||| |  .|| |. ..| . ..|| ..|| .| ||.||.| .|
afsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

ENAKHVQFEQYRISTKFVE-KSPSVITR---CFTVHYMPTSEEREIMILQYIDWPDHGIPPDPqpfISYLRMVKSLRYkfdESIPIVVHCSAGVGRSGVL
 . .    .   || . .  |  .         |..   ... | |  ||. .|||.|.|.     .. . .... ||   .  |.|||||||||||| .
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin...ltainlleavry...dtnpvvvhcsaGvGrsGti

VLSDMLTETYDCG-EVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
|   .. .    | .  |.|  .  || || . .||  || .|. |...| 
vaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 554-796 7.3e-40 131.4 In-house 56-284 (290) alignment 
Range on Protein: 554-796
Range on HMM: 56-284/290.0
NAKKNRYKDIIPYEHNRIRLnpnKNTGSNDYINASLVSysvGsQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENAk
. |||||||..  .  |. |   |. .  ||. |  |    |  .  .|. ||.|. |  |.|.|. ..|.  | || ..||.||.||.||.|. | .. 
efkknrykdvvcndktrvil...kdGydGdyvhanyvk...G.lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev.

hVQFEQYRIS-TKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPpdpQPFISYLRMVKSLRykfDESIPIVVHCSAGVGRSGVLVLSDMLT
 . | .. .  ..  .|   .| . ..|  . .  |  .  |. . |||. ..   .  .. ||....||     | |.|||||||.||.| .|  ..  
.ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksva...lstlallrtlrilr...kasGpvvvhcsaGiGrtGtfvaievgl

ETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
.    |  .|.      ||  |.  ||   ||  |  .....  
qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 529-793 1.4e-39 130.7 In-house 21-234 (392) alignment 
Range on Protein: 529-793
Range on HMM: 21-234/392.0
KVYPEFEEIPPMSLDADTSAgSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSySVgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLIL
 .. || ..|   .  .|.|  ...| ||||||.|.||. .|..|.   ..  .||.||| .  |.  ....|| .|||   .  |||.|......  | 
lffeefhdlpgpdiypqtva.qkeinlkknryknilpydsarvkleviddipdsdylnasyip.sf.dnekayiasqgpnaaslddfwrmvfqenvttia

MLTNIIENGktkchqyfpndeenakhvqfeqyristkfvekspsvitrcftvhymPTSEEREIMILQYIDWPDHGIPPDPQpfiSYLRMVKSLRYKFDES
|.|.. |                                                   . | .   .. .|||...|       | |...| .. .| . 
mvtklkegd..............................................kgddartvaqfhftewPdkdvpkhts...sllkfikevkadfGqy

I-PIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIK
  |...||||||||.||..  | .        ..|.   .. .| .| ..|||  || |.|  ...
thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 533-794 1.7e-39 130.2 In-house 16-268 (281) alignment 
Range on Protein: 533-794
Range on HMM: 16-268/281.0
EFEEIPPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNP-NKNTGSNDYINASLVSYSVgsQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLT
|| ..|        ..  .||| ||||| .|   .  |..|.    |  | ||| |  .   .   .| ||. ||| . | .|||.|||...|  |.|| 
efsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf..lkrgyiltqgpkketradfwrmiwqenttaivmlc

NIIENGKTKCHQYFPNDEEnaKHVQFEQYRISTKFVEKSPSVITRCFTVHYmpTSEEREIMILQYIDWPDHGIPPDPQpfisylRMVKSLRYKFDESIPI
...|  . || .||| .      .||... .| .      |..|  . . |    | | |    . .|||  .|   .       |.| ||     | | 
qfletnrekcaeyfprnah..cclqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpesse......vmlkilrkirarstpp

VVHCSAGVGRSGVLVLSDMLT-ETYDCGEVIDIKSSLARLRLQ-RMHLVQTLGQYRFLYTVIIKY
|.|||||||||| |.  ..     .    . |||  ...||.  |   |||| || ... |.. .
vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 553-795 1.4e-38 127.6 In-house 42-271 (288) alignment 
Range on Protein: 553-795
Range on HMM: 42-271/288.0
VNAKKNRYKDIIPYEHNRIRLNpnknTGSNDYINASLVSysVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENA
 |. ..||...   .  |..|.      .. ||.| .||   .  .|  | .| ||. |   .|.|. |.  . |.||....| || |  .|||    ..
anptrdryenlprcditrvkls....ddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

khVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEERE-IMILQYIDWPDHGIPpdpQPFISYLRMVKSLrykFDESIPIVVHCSAGVGRSGVLVLSDML
  ... ..   .|   .    . .  ...   . ||.  . || . .|.|.|.|   . ..|.||... |    .   |||||.||||||.| |.|. . 
..arigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvP...enylsplrllevl...kslqkPivvhssaGvGrtgtlililia

TETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
 |.    . . |.| ||.|| .|.. .||  || ... .. ...
leslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
0049260 (Phosphotyrosine protein) phosphatases II 598-788 9.3e-38 124.6 In-house 8-143 (152) alignment 
Range on Protein: 598-788
Range on HMM: 8-143/152.0
HRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFpndeenakhvqfeqyristkfvekspsvitrcftvhymptseereimILQYI
.. .| .|||.. |. |||.|..|.. . |.|||.  |.|| ||.||.                                                 ...
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylhl

DWPDHGIPPDPQPFISYLRMVKSLryKFDESIPIVVHCSAGVGRSGVLVLSDMLTetydcgEVIDIKSSLARLRLQRMHLVQTLGQYRFLY
 ||||| |...| ..  |.... |  . |.. |..|||||||||.|.||. ...         ....  .|..| .|.. |.. ||.||||
pwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0046846 (Phosphotyrosine protein) phosphatases II 579-796 1.3e-37 124.6 In-house 9-174 (176) alignment 
Range on Protein: 579-796
Range on HMM: 9-174/176.0
TGSNDYINASLVSYSVgsqhrsYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNdE-ENAKhvqfeqyristkfvekspsvitrc
 .. |||||.|.  |       .|..||||. |. ||..|..|.. .....||. .| |. ||..|.|  . ..                          
dldldyinanlilgsr......piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi........................

ftvhymptseereimILQYIDWPDHGIPPDpQPFISYLRMVKSLRYKfdeSIPIVVHCSAGVGRSGVLVLSDMLTEtydcGEVIDIKSSLARLRLQRM-H
                 ....|||||.|.. . ... |..... . .     |..||||||.||.|.||. ..|      .  ...   ||..| ||. .
...............qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplg

LVQTLGQYRFLYTVIIKYIN
 ||| .|||||| .. ....
avqtpeQyrflyefellllk
subfamily_ptpA1_pd Subfamily ptpA1 541-750 1.4e-37 124.4 In-house 34-251 (418) alignment 
Range on Protein: 541-750
Range on HMM: 34-251/418.0
SLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASlvsYSVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTK
   ..|| | .  |. |||| .|.| .| |..|.  ..   .|||||    |  |.  . .|. ||||  | .|||.|.||.. ..|.||.   || . |
vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinan...yidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrik

CHQYFPNDEENAKH-------VQFEQYRISTKFVEKSP--SVITRCFTVHYmpTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRY----KFDE
| .|.|..    .          |  | .    | . |   .|||   . .    | |.|   ||  |||| ||   |||   |. .   .       | 
cdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf..egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdr

SIPIVVHCSAGVGRSGVLVLSDM
 .||.|||||||||.| .. . .
nvpiivhcsagvgrtgtfctavi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 543-795 7.1e-36 118.4 In-house 44-289 (305) alignment 
Range on Protein: 543-795
Range on HMM: 44-289/305.0
DADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKntgSNDYINASLVSYSVGSQHRsYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCH
 |  .  |. ..  ||||.|.   ... ..|.        ||| |  |   .  ..| .|..||||. |  .|| |. ..| . |.|| . .| || || 
vafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekr.ficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

QYFPNDEENAKHVQFE---QYRISTKFVEKSPSVITRCFTVHYMpTSEEREIMILQYIDWPDHGIPPDPqpfISYLRMVKSLRykfDESIPIVVHCSAGV
||.|    . ....     .    .| .|. . .    . . |   ...  .  ||. .||| |.||     .. | .. ..|      .|||||||||.
qywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppck...ltslellsair...gskvpivvhcsagi

GRSGVLVLSDMLTETY-DCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
||.| .|  . . |   .  ..  .   .  || || . .|.  || |.. |...|.
grtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 553-795 8.6e-34 111.8 In-house 34-270 (285) alignment 
Range on Protein: 553-795
Range on HMM: 34-270/285.0
VNAKKNRYKDIIPYEHNRIRLnpnKNTgSNDYINASLVSYSvGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPndEENA
 |   ||| |.   |  |. |   ||    ||| || .    | .. .||  ||||  |  |||.||...|   .|||  ..| |  ||  |.|  |.  
anpdlnryadvrcieetrvvl...knh.drdyihaswmrmp.gkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp..eklg

KHVQFEQYRISTKFV-E-KSPSVITRCFTVHYM--PTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKfdeSIPIVVHCSAGVGRSGVLVLS
. |.| .| |.   . |      |  ..||      .||   .  .|   |||.  | | .|.|   . || .  |     ||.|||||||||.  .|  
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk...ekpicvhcsagvgrtatfvgi

DMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
|  |        |..   .  .|  |.. ||.  |. ||| |...|.
dyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 532-795 3.4e-33 109.8 In-house 10-259 (267) alignment 
Range on Protein: 532-795
Range on HMM: 10-259/267.0
PEFEEIPPMSLDADTSAGSNPV-NAKKNRYKDIIPYEHNRIRLNpnknTGSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILML
 |||.|  .| .  | . | .  |...||. | .||...|. |     |  ..||||| |      . . .|| |.||. |  ||...| .||   | .|
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegy..ktknafivtqdplkntitdfltvihdqkvpvivll

TNIienGKTKCHQYFPNDEENAKHVQFEQYRISTKFVEKSPSVITRCFtvHYMPTSeEREIMILQYIDWpdhGIPPDPQPFISYLRMVKSLRYKFDESIP
|..   .. . ....|    .||. |      | .  |.   .||  .  ..   |  ... .  |  |    |  . .|..  |  . .     . . |
tkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel..kfknes.ahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrP

IVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
.||.||.|||||| ..  |   |     .| ||   | ..| ||. ||.|. .| ... .. .| 
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 549-707 6.6e-33 108.8 In-house 28-182 (297) alignment 
Range on Protein: 549-707
Range on HMM: 28-182/297.0
GSNPVNAKKNRYKDIIPYEHNRIRLNpnKNTGSNDYINASLVSYSVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPND
   .   .||||.||. .. .|..|   .    .|||||  | .    .   ||. ||||. |  |||....||  . | |.... |.|. ||  |.|. 
akrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

-EENAKHVQFEQYRISTKFVEkSPSVITRCFTVHYMptSEEREIMILQYIDWPDHGIPPD
 .|. |  ..    .|.   |    ||   ... |   ||.| .   |.. |||||.| |
vqerlkagdvvveflsstsde.fdrviltelqliyr..sesrvvrhvqflswpdhGvpsd
0044763 (Phosphotyrosine protein) phosphatases II 565-795 1.8e-32 107.8 In-house 1-171 (178) alignment 
Range on Protein: 565-795
Range on HMM: 1-171/178.0
PYEHNRIRLNPNKNTGSNDYINASLVSysvgsqHRsYIVCQGPLeitcCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEEnakhvqfeqyrist
|....|  |..  .. . |||||| .       .. ..... |      |......|.. ..|..||. .|.|. ||..|.| ...              
pldrtrvllsnleglersdyinaseil......pg.lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..............

kfvekspsvitrcftvhymptseereiMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYkfDESIPIVVHCSAGVGRSGVLVLSDMLTETydcgEViDIK
                           .  ..| .|||| |. .. |   ........   ..  |..|||||||||||.||. ... .      . .. 
...........................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sle

SSLARLRLQRMhLVQTLGQYRFLYTVIIKYI
. ....| .|.  |.. ||.|.|| .  .. 
eaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_CG42327_pd Subfamily CG42327 529-721 4.5e-32 106.0 In-house 6-193 (319) alignment 
Range on Protein: 529-721
Range on HMM: 6-193/319.0
KVYPEFEEIPPMSLDADtsagSNPVNA-KKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSySVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLI
.|. ||...| .   ||      || . .|.|. ...|  . |. |.   .  .. |..|| |     . . ||| .| .|| .  |||...|||... |
dvaeefrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvr.Gyddapnsyiaaqvsledsssdfwrtvweqqsrvi

LMLTNIIENGKTKCHQYFPNDEENAKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYiDWPDHGIPPDPQPFISYLRMVKSL
. ||.. |.|  .| .|.|  |    .  . ..... |  |     ..  . .. .  .| ||.    | .|.. ..| .....|. |  |.| 
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 582-785 4.1e-31 102.8 In-house 75-271 (301) alignment 
Range on Protein: 582-785
Range on HMM: 75-271/301.0
NDYINASLVSYSvGSQHRsYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEEnaKHVQFEQYRISTKFVEK--SPSVITRCFT
   | |  .. | |  || .|. ||||. |. ||| |.   . . | ||.. .|. ..||..|.| . .  .... ....| .|  |.  . ... | . 
rvPihanwipts.Ghphr.fiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis..ekldigrfkikiknkelilnkkiskrtle

VHYMPT-SEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKslrykfDESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLV
|.      . | ..  || .|.|.|.|         . .||      .   |||||||||.|||  .. ...|.   .    |... .|..|| .| . |
vedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk......ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngv

QTLGQYR
||  |  
qtnsqly
0051082 (Phosphotyrosine protein) phosphatases II 582-791 1.1e-30 101.6 In-house 3-149 (151) alignment 
Range on Protein: 582-791
Range on HMM: 3-149/151.0
NDYINASLVSYSvgsqhrsYIVCQGPLEitccDFWQMIWEQKTQLILMLTNIIENGktKCHQYFPNDEenakhvqfeqyristkfvekspsvitrcftvh
.||||.| |          .....|||.    ||.....|.. . |..|..  |.|  .|..|.|. .                                
sdyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

ymptseeREIMILQYIDWPDHGIPPDPQPFISYLRMVKSlrykfDESIPIVVHCSAGVGRSGVLVLSDMLTETydcgevIDIKSSLARLRLQRMHLVQTL
       .|.. ....||||.|.|  .. ....|... .     ... |..||||||.||.|.||. ... .       ... . |. .||.|...||. 
.......ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpn

GQYRFLYTVI
 |..|.. ..
qqflfqlfal
PTPc_DSPc_SM00012 691-792 2.1e-29 97.1 In-house 2-104 (105) alignment 
Range on Protein: 691-792
Range on HMM: 2-104/105.0
IMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDESIPIVVHCSAGVGRSGVLVLSDMLTETYDCG-EVIDIKSSLARLRLQRMHLVQTLGQYRFLYT
.. ..| .|||||.| ........|| ||. ..| ..| |.||||||||||.|..|. |.| .  . . . .||.  . .|| ||...|||. || |||.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VII
...
all
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 557-796 1.8e-28 94.2 In-house 46-277 (312) alignment 
Range on Protein: 557-796
Range on HMM: 46-277/312.0
KNRYKDIIPYEHNRIRLNPNKntgsNDYINASLVSysVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNdeeNAKHVQ
 ||| .|  ..  |. |  ..    | || | .|   . ..   ....||||| ||. |||.     .  |..|. ..|.|  || .|  .       |.
lnrypniqcwdrgrftlagde....nfyihanfvk..ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd...ivgfvd

FEQYRISTKFV------EKSPSVIT-RCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKslrykfDESIPIVVHCSAGVGRSGVLVLSD
.|..|. |...       ||   || | . |    | .|  .   |.  |||||.|   .     |  ||       .  |.. ||||||||.| |.| .
ledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk......kdkkpviahcsagvgrtgtlalie

MLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYIN
 .  .       ..| |.  || .|   |... || .   ...... 
smiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 554-794 2.3e-28 93.7 In-house 52-289 (310) alignment 
Range on Protein: 554-794
Range on HMM: 52-289/310.0
NAKKNRYKDIIPYEHNRIRLNPNKNTgSNDYINASLVSYSVgsQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDE--EN
. .|||| |..  .  |..|. .|    .||| |  |         ..|..||||. |  |||.||...... ||.| .. |.|. ||  |.|     | 
ymhknrysdvvcldtsrvklkidksr.yedyihanyvktny..lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

AKHVQFEQYRISTKFVEKSPSVI---TRCFTVHYMPTS-EEREIMILQYIDWPDHGIPpDPQPFISYLRMVKSLRYKfdesiPIVVHCSAGVGRSGVLVL
   ..  ..  |..  |     .        |   |.  .|  . .... .||| |.| | .      |..  .|.      | |||||||..| .|.| 
ygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvp.dekchtvpqrllaqvrhg.....pcvvhcsagkdrlyvvva

SDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKY
 ..  .  | |. .|..   . |. .|.  .||  || ..  | | .
lklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 554-664 5.2e-27 89.5 In-house 47-169 (350) alignment 
Range on Protein: 554-664
Range on HMM: 47-169/350.0
NAKKNRYKDIIPYEHNRIRLN--------PNKNTGSNDYINASLVSYSVGSQH--RS--YIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKC
   |||||.|.||||.|..|.         .. . .||||||. .. .. |..   .  ||  |.||  |  ||...| . | ..||.||. .|..  ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HQYFPNDEENAKHVQFEQYRIST
..|... . . ..|.... . ..
yrYWqegsydditvklaskweni
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 553-797 6.7e-26 85.6 In-house 46-281 (303) alignment 
Range on Protein: 553-797
Range on HMM: 46-281/303.0
VNAKKNRYKDIIPYEHNRIRLNpnkntgSNDYINASLVSYsvGSQHRSyIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNdeeNA
 | .|||. |.|  .| ...|          || || .     |.... |. | ||  |..|||||| ||| . .|.|    |  |   .  ||.   | 
knmdknrfvdvicldhskvkls......dssyihasylel..dsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr...nq

KHVQFEQYRISTKFVEKspSVITRCFTVHYMPTSE---EREIMILQYIDWPDHGIPPD-PQPFISYLRMVKSLRYKFDESIPIVVHCSAGVGRSGVLVLS
  ..||.  |      .    ..  .... .  |.      . . .| .||   || |    |.  .  ..|.  |. .| | |    .|.||.| . | 
dflkfeersirvgefkr..velgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalf

DMLTE-TYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
.      ..    .|.   |  .|  |.| || | |. ..||.. ... .
etahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 518-797 1.4e-25 84.3 In-house 16-287 (302) alignment 
Range on Protein: 518-797
Range on HMM: 16-287/302.0
AQHLEMILQSGKVYPEFEEIPPMSLDADTsAGSNPVNAKKNRYKDIIPYEHNRIRLNpnknTGSNDYINASLVsySVGSQHRSYIVCQGPLEITC---CD
| .|   |....| .||..|  |  |..    .   | |||. .|.  ...|...|.    .  ..|.||| |  .| . .|| |. | |   .     .
akklvksldtaevkkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskv..evPeltrsiilaQlpkvdsedsvee

FWQMIWEQKTQLILMLTNIIENGKtKCHQYFPNDEEnaKHVQFEQYRISTKFVEKSPSVItRCFTVHYMPTSEEREI--MILQYIDWPDHGIPPDPQPFI
||.|....| . . .|    |  |   ...||.  .  ....... .. .. |||.       ...  .|      .  ..     |... .|      |
FWrmvfqekivsvvilvgeeelkk.tlselfpkksg..dykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeli

SYLRMVksLRYKFDESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
     |     | . . ..|.    |.|| |...   .  |. . |.   ||  .. .| || . |..| || .|| ... || .
ktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
0048076 (Phosphotyrosine protein) phosphatases II 674-794 3.2e-25 83.9 In-house 30-142 (145) alignment 
Range on Protein: 674-794
Range on HMM: 30-142/145.0
ITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKfdeSIPIVVHCSAGVGRSGVLVLSDMLTEtydCGevIDIKSSLARLRLQ
||. ... .... .||... ..|..|||||.|.... ... |....... .     |..|||||||||.|.||. ... .   .|  ... . |...| |
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll...lg..vsleealelvrsq

RMHLVQTLGQYRFLYTVIIKY
|.. |.. ||.|||| .. ..
rpgavpnpgqlrflyefelel
subfamily_egg_pd Subfamily egg 549-795 2.4e-24 80.6 In-house 35-270 (307) alignment 
Range on Protein: 549-795
Range on HMM: 35-270/307.0
GSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSysVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENgkTKCHQYFPND
  .  | .| | | .   .  |..|. ..   ..|.| |  |.   .     .|..| ||  |  |||.|..... | |.|||   |.   .|. |.|. 
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk..Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

EENAKHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSeeREIMILQYI--DWPDHGippDpqpFISYLRMVKSLRykfDESIPIVVHCSAGVGRSGVLV
|...  .    .|| .  |.. .  . |   .. . .   .| . |..   |.   .   |     | ||... ||   . | |.||..  || ....||
esdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdvnnss...d...vysplrvlrklr...nlskpvvvqdilGvskaatlv

LSDMLTETYDCGEVI--DIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
  ..   ..  | .    .. .   |||.|   |..  .| |.| ... ..
aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
0048179 (Phosphotyrosine protein) phosphatases II 677-789 1.6e-23 78.5 In-house 35-139 (144) alignment 
Range on Protein: 677-789
Range on HMM: 35-139/144.0
CFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYkfdESIPIVVHCSAGVGRSGVLVLSDMLTetyDCGevIDIKSSLARLRLQRMH
..| .| |...|||.. .....|||||.|.... ... |.......    |. |..|||||||||.|.||. ...     .|  ..... ||..| .|..
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpg

LVQTLGQYRFLYT
 |.. ||.|||. 
avpnpgqlrfLle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 598-790 5.1e-21 69.8 In-house 4-199 (199) alignment 
Range on Protein: 598-790
Range on HMM: 4-199/199.0
HRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENAKhvQFEQYRISTKFVEKSPSVITRC--FTVHYMPTSEEREIMILQ
.| ||..| ||  | .|||||.||  .  |.|. .   | ..    |.|  |  .   ..    ..|| .   |     .  .|         |||   |
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtg..kygslsvttktittkpdytitaliltnnttappstreishyq

YIDWPDHGIPpDPQPFISYLRMVK--SLRYKFDESIPIVVHCSAGVGRSGVLVLSDMLTETYDC--GEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTV
.  | ..  | .   |. ..   .  | .|. .   |..|||| | | .||.|  |.   ...     |.|.     |||  |  .. .| .| |.| |
ftswkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 598-790 5.4e-21 69.7 In-house 3-198 (198) alignment 
Range on Protein: 598-790
Range on HMM: 3-198/198.0
HRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENAKhvQFEQYRISTKFVEKSPSVITRC--FTVHYMPTSEEREIMILQ
.| ||..| ||  | .|||||.||  .  |.|. .   | ..    |.|  |  .   ..    ..|| .   |     .  .|         |||   |
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtg..kygslsvttktittkpdytitaliltnnttappstreishyq

YIDWPDHGIPpDPQPFISYLRMVK--SLRYKFDESIPIVVHCSAGVGRSGVLVLSDMLTETYDC--GEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTV
.  | ..  | .   |. ..   .  | .|. .   |..|||| | | .||.|  |.   ...     |.|.     |||  |  .. .| .| |.| |
ftswkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 607-794 9.5e-21 68.5 In-house 99-287 (302) alignment 
Range on Protein: 607-794
Range on HMM: 99-287/302.0
PLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPndEENAKHVQFEQYRISTKFVEKSPSVIT-----RCFTVHYMP----TSEEREIMILQYI
|   |.  .| .| . .. ..  |....|... || .|.   ..  ....| .| . |. |..  .  |     . .|| .      .  .. . ||.. 
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyys..dkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

DWPDHGIPPDPQPFISYLRMVKSlrYKFDesipIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKY
 ||||| | .... .  |.  .|  || .    ..|||||||||.| ||      .     .| |. | .  .|  |   ||.  |  .|  .. | 
awpdhGapkeaytaldilkfces..ykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 603-786 2.1e-19 64.6 In-house 39-212 (255) alignment 
Range on Protein: 603-786
Range on HMM: 39-212/255.0
VcqgpleiTCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENakHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDH
.       |   |.|.|  .||. . ||..  |.|. ||..||| . ..  . ....  ..|      . . |.  | ..    . ...   .|  |...
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekde..klkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiek

GIPPDPQPFISYLRMVKslrykfdESIPIVVHCSAGVGRSGVLVLSDMLTE----TYDCGEV--IDIKSSLARLRLQRMHLVQTLGQYRF
  | ...     |..|.       .| ..|||||.|.|||  .|| ...      . |  |   .| .| |  || .|   ..|  |  |
naPelareilnilkvvr.......dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 566-794 2.8e-19 64.4 In-house 30-258 (290) alignment 
Range on Protein: 566-794
Range on HMM: 30-258/290.0
YEHNRIRLNPNKNTGSNDYINASLVSYSVGSQhrsYIVCQGPLEI-------TCCDFWQMIWEQKTQLILMLTNIIENGKT----KCHQYFPNDEEnaKH
 |..|. |.  ..  ..||| |. |... | .    |. | |.|        |  .|| |. . | . . || .  |. .      | .|.|. ..  ..
veatrvvLkgygkrfnddyiHAnrvtcpnglr...liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg..ee

VQFEQYRISTKFVEKSPSVITRCFTVHYMpTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKslRykfdESIPIVVHCSAGVGRSGVLVLSDMLTET
..|.   .. |  ||   |.||  .|..    ||  .   .. .| .  ...|.. ..| ...||       .  |..|||  |. || .|  ...    
lkfkgltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk..a....sktpvivHcvdGiSrsAalaaiilgyQk

YD-CGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKY
     . . ... |  || || .....  .. |   .|. .
iaetsgsvkledvlkalrkqralaitsalelafvdagivll
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 717-795 2.8e-18 60.8 In-house 217-295 (297) alignment 
Range on Protein: 717-795
Range on HMM: 217-295/297.0
MVKSLRYKFDESIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
 ..||| .   .....||||||||||||.||||.. .    . . |... |  || ||  ||||| |. .||....| .
qleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
FERM_N FERM N-terminal domain 22-106 5.5e-18 55.1 Pfam-A 1-80 (80) alignment 
Range on Protein: 22-106
Range on HMM: 1-80/80.0
IVLLDNTSIEINLQPDVTGADCLERVAQCMDIFEIDYFGLQY-QCKDGYDRWVDREKSLRKQLDKhhvggaGARNAELRFLVQYYV
..|||.|  |. .... |||..||.|.. . . | .||||.. . |..  .|.|..|.||.|...         .  | . |..||
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgve......egkpttlllrvkfyv
subfamily_eak_pd Subfamily eak 554-717 6.7e-18 59.2 In-house 52-206 (332) alignment 
Range on Protein: 554-717
Range on HMM: 52-206/332.0
NAKKNrYKDIIPYEHNRIRLNPNKNTgSNDYINASLVSYSVGSqhRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEEnaK
. ..|   .|.||... .|| . .    . ||||||. .|     | ||.   . |     ||||. |||.  |..| . .|..  |  .|||..    .
avnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevG..rkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr..e

HVQFEQYRISTKFVEKSPSVITRCFTVHYmpTSEEREIMILQYIDWPDHGIPpDPQPFISYLRM
 ..| .. . .|   |   . || . ..     |  ...  ..  | .  .|   . |... ..
elkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlp.kyedflalrkv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 555-658 2.2e-16 54.1 In-house 49-166 (349) alignment 
Range on Protein: 555-658
Range on HMM: 49-166/349.0
AKKNRYKDIIPYEHNRIRLNPNK--------------NTGSNDYINASLVSYSVGSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENGKTK
  |||||||.|||| |..|.                  .  .|||||  .. .  | .. ||  | ||  |  ||...|  .. .|.| |..  |..  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHQYFPNDEENAKHVQFE
|..|. . . . ..|.. 
cdiywqelsysnitvklq
subfamily_hpo-7_pd Subfamily hpo-7 610-795 2.9e-16 54.2 In-house 45-227 (263) alignment 
Range on Protein: 610-795
Range on HMM: 45-227/263.0
ITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEENakHVQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQ
 |   |.|.|  .||. . ||..  |.|. || .||| . ..    ....  ..|  | . . . |. ..       . ...   .|  |...  | ...
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekde..kqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

PFISYLRMVKSLRykfdesiPIVVHCSAGVGRSGVLVLSDMLTE----TYDCGEV--IDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
  .  |.... ..       ..|||||.|.|||   .. ...      . |  .   .|  | |  || .|   ..|  |  |   ......
eilnilkvarnsk.......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
FERM_C FERM C-terminal PH-like domain 177-253 2.2e-14 43.8 Pfam-A 3-84 (90) alignment 
Range on Protein: 177-253
Range on HMM: 3-84/90.0
NGTRIWIGACFIGIFIKHSNGQP-TVYFKWPEIVKMKVKDRCFAIETHH----DSIYFKMADTPTAQYVLEMMVQQHMFFQT
.||....| .  |. | ..| .     |.|.|| |.. |.. | |....    | . |..... .....|......| .|..
kgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrdekkkdvlkFyssqlrvnklllklcienhdlfrr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 680-793 3.1e-14 47.2 In-house 80-192 (440) alignment 
Range on Protein: 680-793
Range on HMM: 80-192/440.0
VHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDEsIPIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQ
  |.   | | .   .|  |||.|.|    | .  .. |.  . |  .  |..||||||.||.||..  | .       . ||| | .  .| .| ..||
asyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagn.gpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvq

TLGQYRFLYTVIIK
|  || |.. ....
tpeqyafvheavle
FERM_M FERM central domain 111-170 3.3e-14 43.3 Pfam-A 4-64 (126) alignment 
Range on Protein: 111-170
Range on HMM: 4-64/126.0
KLEYEVTRYLYFLQLKHSVIKGDLKCSSDMAVKLASYALQAEFGDYD-ALIHTPEFLDDHI
... ||...|...|.|.......|.|. ..|..||...||.|.||.. .  ..   |.. .
pkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekee
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 685-795 1.8e-13 44.9 In-house 211-344 (350) alignment 
Range on Protein: 685-795
Range on HMM: 211-344/350.0
TSEEREIMILQYIDWPDHGIPPDPQPFISYLR--------MVKSLRYKFDESIPIVVHCSAGVGRSGVLVLSDMLTE----------TYD----CGEVID
.|.  ... ||.  |.| ..  .|. ... |         ..  . .. ..| ||.||||||||| |.||  |.| .           .       .. |
asdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrD

-IKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
 |.  . .|| ||. .||.| |. |.|  .  | 
lisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_CG42327_pd Subfamily CG42327 729-795 1.3e-12 42.1 In-house 248-315 (319) alignment 
Range on Protein: 729-795
Range on HMM: 248-315/319.0
IPIVVHCSAGVGRSGVLVLSDMLTETYDCG-EVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYI
 |.||||| ||||.|... ||.  .. .   . .||   .  .| .| . |.|  || |.| |. .| 
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 550-637 1.6e-12 41.6 In-house 92-175 (244) alignment 
Range on Protein: 550-637
Range on HMM: 92-175/244.0
SNPVNAKKNRYKDIIPYEHNRIRLNpnKNTGSNDYINASLVSySVGsQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENG
 || |. |||    .|.. ||. |.  | . .| |||||.|   .| .   ||. | ||  |  |||.|. |.. .....|  . |. 
fnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvg.clg.rtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 686-795 2.9e-11 37.3 In-house 215-344 (349) alignment 
Range on Protein: 686-795
Range on HMM: 215-344/349.0
SEEREIMILQYIDWPDHGIPPDPQPFISYLRMVK--------SLRYKFDESIPIVVHCSAGVGRSGVLVLSDMLTE----TYDCGEVID--------IKS
..  |.. ||. .|.| ..  .|. ..  | . .         | .. |.. ...|||||| ||.||||  |.| .    . .    |.        |  
ekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisi

SLARLRLQRMHLVQTLGQYRFLYTVIIKYI
..  || ||. .|| | |. ..|  ..||.
ivnelrkqrismvqnlaqfiaiyealLkyf
0038934 (Phosphotyrosine protein) phosphatases II 687-790 9.2e-11 37.2 In-house 75-172 (194) alignment 
Range on Protein: 687-790
Range on HMM: 75-172/194.0
EEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKfDESIPIVVHCSAGVGRSGVLVLSDMLTEtYDCgeviDIKSSLARLRLQRMHLVQTLGQYRF
 |.  .    . .||.| .|. .   ..|..|.    . |..  ..||| ||.||.|.|| . ..   ...    . . ..|..|  | . ... .... 
fekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyr.lgm....saeeAialfrekRpgaipnqdylea

LYTV
|.. 
llkr
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 554-642 5e-09 30.1 In-house 34-119 (332) alignment 
Range on Protein: 554-642
Range on HMM: 34-119/332.0
NAKKNRYKDIIPYEHNRIRLNPNknTGSNDYINASLVSYSvgSQHRSYIVCQGPLE-ITCCDFWQMIWEQKTQLILMLTNIIENGKTKCH
|   ||   .  ..|.|. | |.   | .|. ||| |     |.. .||..| |..  |   ||.|. |.|  .||.. .| |. | |. 
nmdmnriphlycfdhsrvelapq..dgkddfynaswvdgy..skksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 521-606 4.9e-08 27.1 In-house 15-95 (95) alignment 
Range on Protein: 521-606
Range on HMM: 15-95/95.0
LEMILQSGKVY-PEFEEIPpMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNtgsNDYINASLVSYSvgSQHRSYIVCQG
|||  .| . .  ||  |. |.  |  ..||   |  |||. .|.||.  |. |  ...    ||||| .|     ...  || .||
lemhsnsdqefdnefksis.mtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgy..arkncyiaaqg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 554-631 6.1e-08 26.6 In-house 37-118 (347) alignment 
Range on Protein: 554-631
Range on HMM: 37-118/347.0
NAKKNRYKDIIPYEHNRIRLNPNKNTG-----SNDYINASLVSYSVGSqhRSYIVCQGPLEITCCDFWQMIWEQK-TQLILMLT
. .||| ||    .  |. | |.|        .. ||||| . .   |  . ||. | ||  |  |||.|.   | ||.. .. 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnas..keyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 538-591 6.5e-08 26.3 In-house 31-84 (440) alignment 
Range on Protein: 538-591
Range on HMM: 31-84/440.0
PPMSLDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVS
 | .|   .   | | |  ||||..|. |.|.|. |.  |   ..|||||| ..
lpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 564-648 3e-07 24.8 In-house 3-72 (130) alignment 
Range on Protein: 564-648
Range on HMM: 3-72/130.0
IPYEHNRIRlnpnkntgSNDYINASLVSYSvgSQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIIENgktkcHQYFPND
...| .|..         |.|||||.|  .   . . |.  | ||  |. |||.|. |.   ....|  . |.      .|.|. 
lefevsrlq........gntyinasfvGll..grtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpds
PTEN_1 682-748 3e-07 25.5 In-house 85-150 (196) alignment 
Range on Protein: 682-748
Range on HMM: 85-150/196.0
YMPTSEEREIMILQYIDWPDHGIPPdpqpFISYLRMVKSLRYKFDE---SIPIVVHCSAGVGRSGVLVLS
| ....... ..   ....||| |.    . . ....||.     .      ..||| ||.||||..| .
ydleeffksgveylhfpieDhgaps....lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa
subfamily_PTPDC1_pd Subfamily PTPDC1 689-787 3.5e-07 24.8 In-house 81-168 (182) alignment 
Range on Protein: 689-787
Range on HMM: 81-168/182.0
REIMIlQYIDWPDHGIPPdpqpFISYLRMVKSLRYKFDESiPIVVHCSAGVGRSGVLVLSDMLTEtydcgEVIDIKSSLARLRLQRMHLVQTLGQYRFL
..|..   . |.|.| ..      . | .|| . .  .|   . ||| || || |||. . ..       . .. . ..  .| .| . .|| .| ...
qgiyv.ynfgwkDygvas....leriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqvelv
subfamily_eak_pd Subfamily eak 731-797 5.4e-07 23.3 In-house 239-307 (332) alignment 
Range on Protein: 731-797
Range on HMM: 239-307/332.0
IVVHCSAGVGRSGVLVLSDMLTETYDC--GEVIDIKSSLARLRLQRMHLVQTLGQYRFLYTVIIKYINN
 .. .. |  |.||.|. |.| .  |    ..  ..  . . . .|.| | .  |. |.| ....|. .
piiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 596-682 2.4e-06 21.2 In-house 233-313 (440) alignment 
Range on Protein: 596-682
Range on HMM: 233-313/440.0
SQHRSYIVCQGPLEITCCDFWQMIWEQKTQLILMLTNIieNGKTkCHQYFPNdeeNAKHVQFEQYRISTKFVEKSPSVITRCFTVHY
|.. ..|  | ||. |  |||... . .   |.|| ..  | || |  |.|    |.. | |  . .  |  |.   |  | . ..|
skknafiatqmpldstvldfwrlvhdyristiimlnql..ndkt.csiywpv...ntrsvtfgpftvghkgsenmnrvkvrtlelky
subfamily_PTEN_pd Subfamily PTEN 724-788 4.2e-06 21.9 In-house 110-173 (184) alignment 
Range on Protein: 724-788
Range on HMM: 110-173/184.0
KFDESIPIVVHCSAGVGRSGVLVLSdMLTETYDCGEVIDIKSSLARLRLQRMHLVQTLGQYRFLY
. |..  .|||| || ||.|||. .  | ..  . .  ....  |. | .  . |.   | |...
eedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYve
subfamily_PRL_pd Subfamily PRL 670-751 4.6e-06 20.7 In-house 34-113 (151) alignment 
Range on Protein: 670-751
Range on HMM: 34-113/151.0
SPSVITRCFTVHYMPTSEER-EIMILqYIDWpDHGIPPDPQPFISYLRMVKSlRYKFDESIPIVVHCSAGVGRSGVLVLSDML
. . . |.  . |  .. |. .| .|  . . | | .|  .   ..|...|. ..| . .  . ||| ||.||. |||   ..
evktvvrvceptydteklekegievl.dlaf.ddGavPpeevveeWlellke.kfkeepkstvavhcvaGlGraPvlvalali