Gene PTPN3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP051_AA protein Get Run
AqueP051_AA_585-867 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN3_pd Subfamily PTPN3 587-866 6.1e-138 453.4 In-house 1-280 (280) alignment 
Range on Protein: 587-866
Range on HMM: 1-280/280.0
LRESMVSLKESVLNGSVLVSFDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLDGPVDYINANYVNMDIPSTCQVVRYIVTQGPMQNTCIDF
||||...|||.. .|.||..|..|||||||. . |...|.||||||||||..||.|||.| ....||||||||||.||||..|.|||.||||...|. ||
lresllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdf

WQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRL
||||||| . .|||||...|.|.|||..|||......||| |...||...... ...|..|||...||||..|..||.|.|....||  .||||.|..|.
WqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv

HTLRHGMEDPLVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYI
..||.|.|.|.|||||.||.|.|.....||||..||. |...||.|||.|||||.|.... .||||.|..|...|||...
rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyeeilv
0050432 (Phosphotyrosine protein) phosphatases II 586-861 4.2e-82 271.2 In-house 27-299 (308) alignment 
Range on Protein: 586-861
Range on HMM: 27-299/308.0
LLRESMVSLKESVLNGSVLVSFDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLlDGPVDYINANYVNMDIpsTCQVVRYIVTQGPMQNTCID
 . . .  |..   .| .   | .|...|| . . ...||.| .||||.|| .|| .||.| |.. |||||.||.. .  . .  ..|.||||..||. |
svldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgys..sklprkfIatqgPlpntved

FWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQ--GNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFI
||.|||||..  |||||...| |..||..|||.   |.|.|||.|.... |  ... ...|.. |.|....|.. . |.....| . .||   ...|.|.
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfl

RRLHTLRhgMEDPLVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAY
..... .   . | ||||| |. |.| |.|....|  .|    ....|.|...| || .| . ..||.| .....  .
elvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0051299 (Phosphotyrosine protein) phosphatases II 604-859 5.8e-78 257.6 In-house 26-284 (288) alignment 
Range on Protein: 604-859
Range on HMM: 26-284/288.0
LVSFDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLD----GPVDYINANYVnmdiPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIV
|  |..|....| . . |..||.||.||||.|| .|| .||.| .    .. |||||.|.    .   .  ..|.||||..||. |||.|||||..  ||
leefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi....dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIv

MLTDIMEEGKVKCCRYWPDqGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNN----RTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMED
|||...| |..||..|||. |.|..||...... |  ... ...|.. ..|.     ..|.. ..|.....| . .||    ..|.|.|.... .   . 
mltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasggg

PLVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
| ||||| |..|.| |.|....|  .|  . ...||.|...| || .| . ..||.| ..... 
pvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0036941 (Phosphotyrosine protein) phosphatases II 596-863 3.6e-77 254.9 In-house 8-279 (297) alignment 
Range on Protein: 596-863
Range on HMM: 8-279/297.0
ESVLNGSVLVSFDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLDGPVDYINANYVnmDIPstCQVVRYIVTQGPMQNTCIDFWQMVWEQGC
..  .  .|  |..|.. .. . . ...||.||.||||.|| .|| |||.| |.. |||||.||  |..   .  ..|.||||..||. |||.|||||..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyv..dgy..dlkrkfIatqgPlpntvedFWrmvweqnv

GFIVMLTDIMEEGKVKCCRYWPDQ-GNSTEYGPFQIYCESDRK--DNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHG
  |||||. .| |..||..|||.  |.| .||.|.. . |  .  .. ...|.. .......|.. . |.....| . .||   |..|.||..... .. 
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--MEDPLVVHCSGGIDRSGIFVAMETALTKIE---IVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEE
   . | .||||.|. ||| |.|....|  .|   . . ...||.|...|.|| .. . |.||.| .... . .  
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0040438 (Phosphotyrosine protein) phosphatases II 607-871 4.3e-77 254.8 In-house 24-286 (317) alignment 
Range on Protein: 607-871
Range on HMM: 24-286/317.0
FDRLYRKKPGmLTIASKLPQNLSKNRYRDITAYDITRVHLLDGP----VDYINANYVnmdiPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLT
| .|.. |.   .  ..||.| .||||.||  || .||.| . .     |||||.||    .   .  ..|.||||..||. |||.||||||.. |||||
fedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv....dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

DIMEEGKVKCCRYWPDqGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCS
. .| |..||..|||. |....||.|.. . |  ... .. |.. .......|.  . |.....| . .||    ..|.|...... . . . |..||||
eleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCs

GGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIEIDLS
.|..|.| |.|....|  .|  . ... |.|...| ||... . ..||.| .|.. . .   .  ...|
aGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepas
0047943 (Phosphotyrosine protein) phosphatases II 598-858 4.1e-76 251.3 In-house 9-269 (273) alignment 
Range on Protein: 598-858
Range on HMM: 9-269/273.0
VLNGSVLVSFDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLDGPVDYINANYVnmdiPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGF
  .. .|  |..|.. || . . ...||.|..||||.|| .|| .||.| ||. |||||.||    .   .  ..|.||||..||. |||.|||||..  
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyv....dgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLTDIMEEGKVKCCRYWPDQGN--STEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHG--M
|||||...| |..||..|||. |.  |..||.|.... |  ... ...|.. |.|. |.|.. ..|.....| . .||   ...|.||. ... ..    
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

EDPLVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIV
. | |||||.|. |.| |.|....|  .|    ...||.|...|.|| .| . ..||.| .....
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0046845 (Phosphotyrosine protein) phosphatases II 609-861 2.2e-75 249.0 In-house 8-274 (284) alignment 
Range on Protein: 609-861
Range on HMM: 8-274/284.0
RLYRKKPGM--LTIASKLPQNLSKNRYRDITAYDITRVHLLD-----GPVDYINANYVNMD-IPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVM
.|.. .. .   . ...||.|||||||.|| .|| .||.|       .  |||||.||..  .. | .  ..|.||||..||. |||.|||||..  |||
ellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVm

LTDIMEEGKVKCCRYWPDQGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNR-TKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRH--GMEDPL
||...| |..||..|||. |.. .||.|.... |  ... ...|.. |.|.  |.|.. ..|.....| . .||   .|.|.|.| ...|.   . . | 
ltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpi

VVHCSGGIDRSGIFVAMETALTKIEIVE---AFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAY
|||||.|. |.| |.|....|. .|  .    ...||.|...|.|| .|   | ||.| ..... ..
vVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 620-859 1.7e-73 243.4 In-house 48-302 (307) alignment 
Range on Protein: 620-859
Range on HMM: 48-302/307.0
IASKLPQNLSKNRYRDITAYDITRVHLLD-----GPVDYINANYVNMDIPSTC----QVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKV
 ...||.| .||||.|| .|| |||.| .     .. |||||.||..... ..    .  ..|.||||...|. |||.|.||||.. |||||. .| |..
siallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgre

KCCRYWPDQGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNN-RTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHG--MEDPLVVHCSGGIDR
||..|||| | . .||.|.... |  ... .. |.. ....  |.|.  ..|.....| . .||   ...|.||..... ..    . | .||||.|..|
kcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgR

SGIFVAMETALTKIEIVEA---FNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
.| |.|. ..|. .|  .    ...||.|...|.||. . . ..||.| .... .
tGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0043336 (Phosphotyrosine protein) phosphatases II 601-858 3.7e-73 241.7 In-house 20-274 (278) alignment 
Range on Protein: 601-858
Range on HMM: 20-274/278.0
GSVLVSFDRLYRKKPgMLTIASKLPQNLSKNRYRDITAYDITRVHLLDGP----VDYINANYVnmdiPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCG
  .|  | .|.. |. . .  ..||.| .||||.|| .|| .||.| . .     |||||.||    .   .  ..|.||||...|. |||.||||.|. 
tllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv....dgynvprkfiatqgPlpetvedFwrmvwelgvt

FIVMLTDIMEEGKVKCCRYWPdqGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDP
 |||||. .| |.|||..|||  |.|..||.|.... .  ... ...|.. ..|....|.. . |...|.| . .||   ...|.|...... ..  . |
tivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngp

LVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIV
..||||.|..|.| |.|....|. .|    ....|.|...| ||..... ..||.| .... 
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
DSPc_SM00195 607-861 6.1e-73 240.7 In-house 6-262 (263) alignment 
Range on Protein: 607-861
Range on HMM: 6-262/263.0
FDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLDG----PVDYINANYVNMDipstCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLT
|..| ....   |  .. ..| |||||..|  || |||.| .     . |||||||....     .  .||.||||...|. |||.||||...  |||||
fekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

DIMEEGKVKCCRYWPDQ-GNSTEYGPFQIYCESDRKDN-LCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVH
. .|.|| || ||||.. |.....| ... . .  |..  . .|.. |... ..|.. . ..|. .| ...||  . ..|...| ... .   . |.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAY
|| |..|.|.||.....| |.|  . ..  |||...|.|| .|   |.||.| ...|....
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 607-861 6.1e-73 240.7 In-house 6-262 (263) alignment 
Range on Protein: 607-861
Range on HMM: 6-262/263.0
FDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLDG----PVDYINANYVNMDipstCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLT
|..| ....   |  .. ..| |||||..|  || |||.| .     . |||||||....     .  .||.||||...|. |||.||||...  |||||
fekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

DIMEEGKVKCCRYWPDQ-GNSTEYGPFQIYCESDRKDN-LCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVH
. .|.|| || ||||.. |.....| ... . .  |..  . .|.. |... ..|.. . ..|. .| ...||  . ..|...| ... .   . |.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAY
|| |..|.|.||.....| |.|  . ..  |||...|.|| .|   |.||.| ...|....
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRD_pd Subfamily PTPRD 615-877 7.4e-73 241.1 In-house 36-297 (564) alignment 
Range on Protein: 615-877
Range on HMM: 36-297/564.0
PGMLTIASKLPQNLSKNRYRDITAYDITRVHL----LDGPVDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKV
. . . |.. |.| .|||| .|.||| .|| |     |   |||||....    .  .   || ||||...|. |||.||||| .  ||||| . |.|||
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkv

KCCRYWPDQGnSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGI
|| .|||..| ...|| ...  |.  . .  . |.| ||.....| . . . .| .| ...||   ...|..||. ..|..  . |.||||| |. |.|.
kchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGt

FVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIEIDLSNHANNV
|....  | .|.  .  .  ..|...| || .|    .|| |  . |..| .    |.. .|  ...
fividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhl
0039614 (Phosphotyrosine protein) phosphatases II 601-859 2.6e-72 239.1 In-house 32-287 (297) alignment 
Range on Protein: 601-859
Range on HMM: 32-287/297.0
GSVLVSFDRLYRKKPGmlTIASKLPQNLSKNRYRDITAYDITRVHLLD-----GPVDYINANYVnmDIPST-CQvvRYIVTQGPMQNTCIDFWQMVWEQG
. .|  | .|.. ||   .  ..||.| .||||.|| .|| .||.| .      . |||||.||  | ..  ..  ..|.||||...|. |||.||||||
tllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltr..kfIatqgPlpetvedFwrmvweqg

CGFIVMLTDIMEEGKvKCCRYWPDQGNstEYGPFQIYCESDRKDNLCCTRHFVLKNnrTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHG--
.  |||||. .| |. ||..|||. |.  .||.|.... .  ... ...|.. ..|  ..|.. . |.|...| . .||   ...|.|.. ... .    
vtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelp

MEDPLVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
 . | .||||.|..|.| |.|. ..|. .|    ...||.|...| ||... . ..||.| .|....
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
Y_phosphatase Protein-tyrosine phosphatase 627-858 1.9e-70 232.3 Pfam-A 1-234 (235) alignment 
Range on Protein: 627-858
Range on HMM: 1-234/235.0
NLSKNRYRDITAYDITRVHL--LDGPVDYINANYVnmdiP---StcqVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWP-DQG
|..||||.||..|| |||.|   .|| ||||||||        .     ..|.||||...|. |||.|||.. . .|||||. .|.|..|| .||| ...
nkkknRykdilpydktrvklkgsegpsdYInAnyv....kgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeee

NSTEYGPFQIYCE-SDR-KDNLCCTRHFVLKNNRTK-EEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETA
.|..|| ... .. .   ... ...|.. ||.. .. |.. . .|.. .| ...||  . ..|..||.... ..  . |.||||| |. |.|.|||....
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

LTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIV
| ..|  | .. |.||...| || .|   |.||.|....|.
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 627-858 1.9e-70 232.3 In-house 1-234 (235) alignment 
Range on Protein: 627-858
Range on HMM: 1-234/235.0
NLSKNRYRDITAYDITRVHL--LDGPVDYINANYVnmdiP---StcqVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWP-DQG
|..||||.||..|| |||.|   .|| ||||||||        .     ..|.||||...|. |||.|||.. . .|||||. .|.|..|| .||| ...
nkkknRykdilpydktrvklkgsegpsdYInAnyv....kgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeee

NSTEYGPFQIYCE-SDR-KDNLCCTRHFVLKNNRTK-EEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETA
.|..|| ... .. .   ... ...|.. ||.. .. |.. . .|.. .| ...||  . ..|..||.... ..  . |.||||| |. |.|.|||....
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

LTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIV
| ..|  | .. |.||...| || .|   |.||.|....|.
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0045098 (Phosphotyrosine protein) phosphatases II 606-861 6.8e-70 230.9 In-house 12-272 (278) alignment 
Range on Protein: 606-861
Range on HMM: 12-272/278.0
SFDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHlldgpvDYINANYVNMDiPstcqvVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIM
 |..|..  .      . .. ||.||||.|| .|| .||.      |||||.|...  |      ..|.||||...|. |||.|.||.|.  |||||. .
efefllllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy.p.....kkfIatqgPlpstvadfwrmlwelgitvivmltelv

EEGKVKCCRYWPDqGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNN----RTKEEKPIIHLQFLDWSESNVPLVK--ADFLRFIRRLHTLRH--------
| |..||..|||. |.| .||.|.....|    .  ..|.. . |      . |.  . ||..| | . .||     . ||.......  .         
elgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

-----GMEDPLVVHCSGGIDRSGIFVAMETALTKIEivEAFNPLEIVRMMRDQRGM-MLPALNQYKFFCDCIVQAY
     . . | .|||| |..|.| .||. . |. .|  . ...||.|...| ||.. ... |.||.| ...... .
slllldsggpvlVHCsaGvgRtGtlvaaylmlelle..ggvdlleavkelrsqRpglavqnleqyrflyefllell
0042113 (Phosphotyrosine protein) phosphatases II 623-859 4.9e-68 224.5 In-house 5-241 (245) alignment 
Range on Protein: 623-859
Range on HMM: 5-241/245.0
KLPQNLSKNRYRDITAYDITRVHLLDGP----VDYINANYVnmDIPSTCQVvrYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPD
.|| | .||||.|| .|| |||.| . .    .|||||.||  | .  ..   .|.||||...|. |||.|.||.|.  |||||. .| |.|||..|||.
llpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpk..fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

qGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRH-GMEDPLVVHCSGGIDRSGIFVAMETA
 |.|..|| |.... |  ... ...|.. ..|....|.. .||...|.| . .||   ...|.|...... .. . . |..||||.|..|.| |.|. ..
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
|. .|    ... |.|...|.||... . ..||.|  ... .
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0040439 (Phosphotyrosine protein) phosphatases II 622-859 2.6e-67 222.4 In-house 6-244 (249) alignment 
Range on Protein: 622-859
Range on HMM: 6-244/249.0
SKLPQNLSKNRYRDITAYDITRVHLLD----GPVDYINANYVnmdiPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWP
..|| |..||||.|| .|| .||.| .     . |||||.|.    . . .  |.|.||||...|. |||.|.||.|.. |||||. .| |..||..|||
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyi....dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DqGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHG--MEDPLVVHCSGGIDRSGIFVAME
. |.|.||| |.. . |  . . ...|.. |.|. ..|.  . |.|..|| . .||   .|.|.||..... ..    . |..||||.|..|.|.|.|. 
l.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

TALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
..|. .|    ....|.|...|.||... . ..||.| .... .
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 606-860 3e-66 218.4 In-house 20-275 (281) alignment 
Range on Protein: 606-860
Range on HMM: 20-275/281.0
SFDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHL----LDGPVDYINANYVnmdiPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVML
 .. |.    .  . ||| ..|  ||||..|.||| |||..     .   ||||||.|    |.  .  .||.||||. ... .||||||||    |||.
eyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfv....pgykgekeyiatqgPvPaslvafWqmvweqkvsaivmv

TDIMEEGKVKCCRYWPDQGNSTEYGPFQIYCESDRKDNLCCTRHFVLkNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHT-LRHGMEDPLVVH
|  .|.||.|| |||||. ....|| ...  .. .. .   .|.| | .... |.. . .|... | .  ||   ...| | . ..   ..  . |||.|
treieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvih

CSGGIDRSGIFVAMETALTKIE-IVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQA
|| |. |.| ..|..... ..|   |  .. ..|. .| .| .|. .. ||.|    ...|
CsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_PTPN14_pd Subfamily PTPN14 593-860 2.1e-65 215.7 In-house 15-295 (300) alignment 
Range on Protein: 593-860
Range on HMM: 15-295/300.0
SLKESVLNGSVLVSFDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLL---DGPVDYINANYVNMDIpsTCQVVRYIVTQGPMQNTCIDFWQM
 |.. . .| | . ..|. .|.   |. ..|||.| .|||..|.  |. .||.|    .   .||||  ... .  . .   |||.|||...|. |||||
ilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsv..ggkersyivaqgPleltvqdfWqm

VWEQGCGFIVMLTDIMEEGKVKCCRYWPDQ---GNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRL
|||||   |||||.. |.|| |. .|.|..    .. |.| |... .  .. . . |. . ||   .|||. ..|||. ||.. .||    .|| .....
vWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeev

HTLRHGM---------EDPLVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQA
. .|. .         . |..|||| |. |.|. .  .  .. .|  |  .  ......| || .....| ||||  . ... 
qsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 605-877 9.1e-64 210.5 In-house 24-296 (318) alignment 
Range on Protein: 605-877
Range on HMM: 24-296/318.0
VSFDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLDGP----VDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVM
  ..|| |..  . .. |  | |  |||| .|.||| |||.| .       |||||||..       .   || .|.|. .|. |||.|||||..  |||
eeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyid....GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivm

LTDIMEEGKVKCCRYWPDQGnSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLR-HGMEDPLVV
||...|.||.|. ||||..| |..||  ..  ... . .    |.| .... ..|.. .   .. .|....||   |..| ..|. ..   .  ..|.||
ltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivv

HCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIEIDLSNHANNV
|||.|. | |.|.|... | .|.  .  . ...|...|.|| .|  . .||.|  | ...| .    |.| |. ....
hCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsri
subfamily_PTPRB_pd Subfamily PTPRB 617-863 1.6e-63 209.5 In-house 41-287 (293) alignment 
Range on Protein: 617-863
Range on HMM: 41-287/293.0
MLTIASKLPQNLSKNRYRDITAYDITRVHL----LDGPVDYINANYvnmdIPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKC
. . |..|..| .||||..| .|| .||.|     .   |||||||    ||   .   .|.||||. .|  |||.||||. .  |||||...|.|||||
qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany....ipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkC

CRYWPDQGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNnrTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLR--HGMEDPLVVHCSGGIDRSGI
 .|||.. ... ||  ..   .... .   .|.. ...  .|||. . ...|. |.. .||   . .|.|.|....    .  . |.||||| |. |.|.
eeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGt

FVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEE
|.|... | .||  .  . . ||  .| .| ... . .|| |  .|...  ..
fialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 620-864 2.3e-63 208.9 In-house 40-282 (288) alignment 
Range on Protein: 620-864
Range on HMM: 40-282/288.0
IASKLPQNLSKNRYRDITAYDITRVHLLD----GPVDYINANYVNMDipstCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRY
 |..|..| .|||||.| .|| .||.| .       |||||.|.. .     .  .|| ||||...|  |||..|.|.    |||||...|.|| || .|
tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge....kkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeY

WPDQGNSTEYGPFQIYCESDRKDNLCCTRHFVLKnnRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAME
|||... ..|| ...   .... .   .|.. |.  ..|.|  | ..|.| |.. .||  ||..| ..| ...  .    |..|||| |. |.|.|.|..
WPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFiald

TALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEED
... ..|  .  . ...|  .| || ..   |.|| |  .....  |||
alidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_PTPN13_pd Subfamily PTPN13 607-860 4.1e-63 208.2 In-house 17-268 (273) alignment 
Range on Protein: 607-860
Range on HMM: 17-268/273.0
FDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLDGPVdYINANYVNMDIpsTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIME
|. |   ||   .  .|  .| .|||||..  || |||.| |    ||||..... .    .  .||..|||. .|. ||||||||| .  |.|.|   |
fkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtleke

EGKVKCCRYWPDQGNST--EYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHgMEDPLVVHCSGG
.||||| ||||.. |..   .. ...  .   | .    |.. .|.....| . . ||.| .| . .||   |..|.|.... .|..  . |.||||| |
kgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaG

IDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQA
| |||........|  ||  . |.  |||| .|.||  .. . .|| |    |...
iGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
0037934 (Phosphotyrosine protein) phosphatases II 622-859 2.5e-62 205.9 In-house 5-240 (243) alignment 
Range on Protein: 622-859
Range on HMM: 5-240/243.0
SKLPQNLSKNRYRDITAYDITRVHLlDGpVDYINANYVNMDiPstcqvvRYIVTQGPMQNTCID----FWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWP
..||.|||||||.|| .|| .||.| .|  ||||||....  |      |.|.||||...|. |    ||.|.||.|.. |||||. .| |..||..|||
allpenlsknrysdilpydhsrvkl.eg.sdyinanliyvt.p......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dqgNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNR-TKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGM--------EDPLVVHCSGGIDRS
   ....||.|.. . | .  . .. |...|.|   ..... .||...| | . .||   .|.|.|.. ...  . .        . |..||||.|..|.
...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GIFVAMETALTKIeiveAFNPLEIVRMMRDQRGM-MLPALNQYKFFCDCIVQ
| ..|. . |...     ....|.|...|.||.. . . ..||.|  ... .
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPRK_pd Subfamily PTPRK 622-860 5.6e-60 197.8 In-house 38-276 (314) alignment 
Range on Protein: 622-860
Range on HMM: 38-276/314.0
SKLPQNLSKNRYRDITAYDITRVHLL--DGP--VDYINANYVnmdiPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWP
.|  .| .|||. || ||| .|| |   ||    |||||...     |  .   .||||||.|.|  |||..|....|  |||||...|.|.|||..|||
akkdenreknrsgdilaydrsrvflitidgdpssdyinaali....dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP

DQGNSteYGPFQIYCESDRKDNLCCTRHFVLKN-NRTKE-EKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAME
....   ||.... . .   ..   .| | ... .|..|  . . ..||| |.. .||  .  .|...||... ..  . ..||||| |  |.|.|.|..
edtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaid

TALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQA
. |  ||  .  .  ..|. .|...  |. . .||||  | |..|
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_PTPN6_pd Subfamily PTPN6 622-863 4.4e-59 195.0 In-house 49-298 (306) alignment 
Range on Protein: 622-863
Range on HMM: 49-298/306.0
SKLPQNLSKNRYRDITAYDITRVHLLDGPV---DYINANYVNMDIPSTCqvVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPD
.. |.| .||||. |  .| ||| | .  |   |||||||.. ......   .|| ||| ...|  |||.|||.. .  |||.|  .| || ||.|||||
gakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd..ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPd

QGNSTEYGPFQIYCESDRKDNLCCTRHFVLK-NNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGME----DPLVVHCSGGIDRSGIFVA
. ...|||  .. . |... .    |..... ... |||. .....| .| . .||  .  .| |.. ... .. .|     |.||||| || | | |. 
eeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiv

METALTKIEIVEAFNPLE---IVRMMRDQRGMMLPALNQYKFFCDCiVQAYEE
... | .||      ...   .|...|.||  ..   .||||     ...| |
iDillkliekkgldadidiqklvksvreqrsglvqteqqykfvyka.ikkyie
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 621-875 1.9e-58 193.0 In-house 42-297 (319) alignment 
Range on Protein: 621-875
Range on HMM: 42-297/319.0
ASKLPQNLSKNRYRDITAYDITRVHLLDGP----VDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYW
 .. ..| .||||..| ||| ||| | . .     |||||....    .  . ...| ||.|..||  |||.||||...  .||||.. |..|||. .||
saskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid....gyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkyw

PDqGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTK-EEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHG-MEDPLVVHCSGGIDRSGIFVAM
|.  | .||| . .  |.... .    |.. |... .. | . . | |...|.. .||      | ...|..  |..  . |.||||| |. | | |...
pe.enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivl

ETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIEIDLSNHAN
. .| ...  .. .  ..|...| || .|    .||||  . ...| |    ||.. .  .
damlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrd
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 618-860 4.3e-58 191.9 In-house 47-289 (298) alignment 
Range on Protein: 618-860
Range on HMM: 47-289/298.0
LTIASKLPQNLSKNRYRDITAYDITRVHLLD----GPVDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCC
 . ... |.| .|||| || |.| .|| | .       ||||| ...    .  .   .|.||.|...|  |||.||.|.  | |||||.. | .|.|. 
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh....aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyh

RYWPDQGnSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGME-DPLVVHCSGGIDRSGIFV
.||||.| ...|| ...   |. .     .|.. ........|. . .|.|  |..  || ..   | ..|. .. ..     |..|.|| |..||| |.
kywPdeg.ketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfi

AMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQA
|... | .... .    ...|...| .|  .. . .||.|  . . .|
aidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_PTPN23_pd Subfamily PTPN23 627-861 1.9e-57 189.3 In-house 43-280 (288) alignment 
Range on Protein: 627-861
Range on HMM: 43-280/288.0
NLSKNRYRDITAYDITRVHLLDGPVDYINANYVNmDIPSTCQvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPD-QGNSTEY
. .|||.|||  || .||.| ..  ||||| .|. |. ..|    .|.||.|.|.|  |||.||.||    ||||..  | || |. ||||  .|.....
yseknrsrdilPyDhnRvklrgskDDYinAsfvk.dlspgcP..dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

GPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHT----LRHGMEDPLVVHCSGGIDRSGIFVAMETALTKI
|.... ..| |. . .  |.. |. ..... | . |||.  |.|  ||    ..|.|.   ..     .. .. ||||||| |..|.|.|  . .|....
gdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel

EIVEAF-NPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAY
|  .   . ...|. .| ||  |.   .|.||  . ...| 
ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Ptp69D_pd Subfamily Ptp69D 589-874 2.7e-57 189.2 In-house 11-299 (307) alignment 
Range on Protein: 589-874
Range on HMM: 11-299/307.0
ESMVSLKESVLNGsVLVSFDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLD----GPVDYINANYVNmdipSTCQVVRYIVTQGPMQNTCI
|...| |.    | ..  ...| ...    | .|.   |. |||| ||.|.| ||| |         |||||....    .  .  ..|. |.|...|  
ealksrkrdtdfg.lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik....gykekkkfiaaqdPveatig

DFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQgNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNR-----TKEEKPIIHLQFLDWSESNVPLVKADF
|||.|..||    ||||... |  . || .|||.. . ..||   . . | .| .    |.. . ..       .... ..  ... | .|.|| |    
DfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargl

LRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIEIDLSNHA
|..|.... | .  . |.||||| | .|||||||..  | ...  .  .  |.|. .| || ...  |.||.|    ...  .    ..|. . .
lklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddle
subfamily_PTPN9_pd Subfamily PTPN9 618-858 4.9e-56 184.9 In-house 33-287 (297) alignment 
Range on Protein: 618-858
Range on HMM: 33-287/297.0
LTIASKLPQNLSKNRYRDITAYDITRVHLL----DGPVDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCC
   ||||. ||.|||| |.  || |||.|     |   ||||||.|.       |   .| ||||...|. |||.||||| .  ||| | ..|.|..|| 
tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvd....GykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcg

RYWP-DQGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRR---LHT----------LRHGMEDPLVV
.||| ....|.|.| ...   .... .   .| ...|| .|.|.. ..| ||| | .  ||   |..| ...      .            |  . |.||
qyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivv

HCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIV
||| || |.| |.... .|...| |.  .  | |...| ||  ..   .||.|   ...
hcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl
subfamily_PTPN1_pd Subfamily PTPN1 619-859 9.7e-55 180.3 In-house 24-269 (290) alignment 
Range on Protein: 619-859
Range on HMM: 24-269/290.0
TIASKLPQNLSKNRYRDITAYDITRVHLLDGPVDYINANYVNMDIPSTcqvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPD
| ..|||.| ..|||||.. || .|..| .. .|||||. |...        .||.||||. ||.  |||||||| .  .|||  ..|....|| .||| 
treaklpenrnlnryrdvspydhsrikleradndyinaslveleeakr....syiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

QG--NSTEYG--PFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHT---LRHGmEDPLVVHCSGGIDRSGIF
.   .. ..    ...   |  . .    |.. |.| .|.| . |.|  .. |..  ||   | ||.|. ..     | .    | |.||| || ||| |
geeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssd.vGpavihcsaGiGrsGtf

VAMETALTKIEIVEAFNPLEIVRM---MRDQRGMMLPALNQYKFFCDCIVQ
. ..| | .||  .  . ..| ..   .| .|  .. . .| .|    |..
clvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 606-877 1.1e-54 180.7 In-house 27-299 (305) alignment 
Range on Protein: 606-877
Range on HMM: 27-299/305.0
SFDRLYRKkPGMLTIASKlPQNLSKNRYRDITAYDITRVHLLDGP----VDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVML
 .. ||.. . .. . .|  .| .|||...|| .|  |..|   .     |||||.||.    .  .  .|||.|||..||  |||....|     ||||
qykslyee.eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvd....gykrkkkyivaqgPlkntvadfWrliveekvstivml

TDIMEEGKVKCCRYWPDQGNS-TEYGPFQIYCESDRKDNLCCTRHFVLKN-NRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGM-EDPLV
|...|.|| || .|||.. .  .|.|.|..  .| .. .   .|.. . . .  ||.. ....|. || .  ||   . .|..|.|..  ..   . ||.
tklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpll

VHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIEIDLSNHANNV
|||| |. |.|.|.|.. || ...  |  .  |... .| .|  |.  |.|| |  | . .  .  . .|  ||   .|
VhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv
subfamily_PTPN12_pd Subfamily PTPN12 611-863 2.4e-54 179.2 In-house 24-279 (290) alignment 
Range on Protein: 611-863
Range on HMM: 24-279/290.0
YRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLD----GPVDYINANYVNMdipsTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIME
|...  . | |.. ..|  ||||.||  || .||.|         ||||||...     . . ..|| .|||. .|  |||.|.||.    .||.  ..|
ykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg....vegkleyiaaqgPLpktlddfWrmiweknveivvmaCreve

EGKVKCCRYWPDQGNSTE-YGPFQIYCESDRK-DNLCCTRHfvLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGG
 || || ||||..|...  .|.|.. .|.... |.    |   || .. ||.. .  ... .| . .||  . . |..|. ...|..  . ||||||| |
lgkkkCerYWpeegeeelefgefevtleeekavdddflirt..LkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaG

IDRSGIFVAMETA---LTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEE
. | |. .|.. .   | .  | | ..  ..|. .| ||  .  . .||..   ....  ..
vGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_PTPRG_pd Subfamily PTPRG 621-862 3.1e-54 179.1 In-house 41-288 (563) alignment 
Range on Protein: 621-862
Range on HMM: 41-288/563.0
ASKLPQNLSKNRYRDITAYDITRVHLLDGP-----VDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRY
.|. |.|  |||| .|.||| .||.| . |      |||||||..       .   .|.||||...|. |||.|.|||    |||.|.. |.|. || .|
hsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid....GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvY

WPDqGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKE------EKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSG
||   .| .|| .|.  ..  .  |  .|..|.|| . |.      || ... .. .| . .||  ..  | |...  . ..    |.||||| |. |.|
WPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtG

IFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYE
......| | .|.  .| | .......| || ...   .|| |  | ...|  
tyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 621-860 3.1e-53 175.5 In-house 27-266 (283) alignment 
Range on Protein: 621-860
Range on HMM: 27-266/283.0
ASKLPQNLSKNRYRDITAYDITRVHLLDGPVDYINANYVNMDiPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQG
 .   .|  |||...| ..|  ||.|   . ||||| .. ..  |  |  .||..|.|...| .|||.||...    ||||| ..|. ..||..||| .|
iasadenkrknrnqeivpadqwrvelksesrdyinavfipvs.ksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

nSTEYGPFQIYCESDRKDNLCCTRHFVLKNN-RTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETALT
 | .||.| .  . .   |    . ..|..|  .|..  . | |. || | .   .   ...| .     ..  . |.||||| || |...|.|. ... 
.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvk

KIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCI-VQA
..      .  ..|..|| || |.. .|.|||.  . .  ||
daltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 621-862 6e-52 171.3 In-house 40-284 (290) alignment 
Range on Protein: 621-862
Range on HMM: 40-284/290.0
ASKLPQNLSKNRYRDITAYDITRVHLL------DGPVDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCR
    ..|  .||...|  ||  |. |       | . .|||| |..       .  .||.||||..|| .|||...|.. .  |||||.|.|||||||  
vgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik....gykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqq

YWPDQGNSTeYGPFQIYCESDRKDNLCCTRHFVLKNNRT-KEEKPIIHLQFLDWSESN-VPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFV
||||..... ||.|.|   .... |   .|.. .||... .... ....|.  | .   |.  ..  | . .. .| |.  . ..|||||... ||..|.
YWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfc

AMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYE
|..|.. | ..    . ..... .| |.  .. . .||.. .. .... .
aaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_PTPRA_pd Subfamily PTPRA 620-872 2.5e-51 169.5 In-house 52-306 (330) alignment 
Range on Protein: 620-872
Range on HMM: 52-306/330.0
IASKlPQNLSKNRYRDITAYDITRVHLL--DG--PVDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRY
.|||  .|  |||. .|  || .||.|   .|    ||||| ...       .  ..| .||| ..|  |||.|.|||    |||||.. |  . || .|
lask.eenkeknrvvnilPydfsrvilsvkeGveesdyinasfid....GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy

WPDQGNSTeYGPFQIYCESDRKDNLCCTRHFVLK----NNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIF
|||.|  | ||  ..  | .   .    |.|...    . | |... .  . |  | .  ||      |........|.. . .|.||||| |. |.| |
wPdeGlvt.yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtf

VAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIEIDLSN
..... | ...  .  .  |.|. .| ||  |. ...||.|    . . |     |.|.| 
ivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvss
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 624-860 2.7e-50 165.9 In-house 44-277 (287) alignment 
Range on Protein: 624-860
Range on HMM: 44-277/287.0
LPQNLSKNRYRDITAYDITRVHLLDGPVDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGNsT
 .||  |||...|  .|  || | .   ||||| ...    .  .  ..|....|| ||  .||......    ||||.. .|. . .| .|||.. . .
asqnkdknRltqilvpdnyrvllkgehpdyinavfid....gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.v

EYGPFQIYCESDRKDNLCCTRHFVLKNNR-TKEEKPIIHLQFLDWSESN-VPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETALTKI
 .|...|   .. . . .  |.. .||.  ..... .   |. .| .   |.  .. .| . .. .| |.  . ..||||| .. ||..|.|..|.. | 
vlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkc

EIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQA
.   . . ..... .| |.  .. . .|||| .| ... 
kteGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 622-860 3.5e-50 165.5 In-house 4-241 (250) alignment 
Range on Protein: 622-860
Range on HMM: 4-241/250.0
SKLPQNLSKNRYRDITAYDITRVHLLD----GPVDYINANYVNMDIPStcqvVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVkCCRYWP
.| |||. |||| || |.| .|| |         ||||| ...    .      .|.||||.|.|  |||.||.|.  | |||||.. |..|. . .|||
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder....kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP

DQgNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHG-MEDPLVVHCSGGIDRSGIFVAMET
 . ....||  ..   |. .     .|...| ... ..|. . .|.|. | .  || |    | ....... .    . |..|.|| |. ||| |.|...
ve.kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

ALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQA
 | .... .  .  ......| .|  .. .|.|| |    | .|
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 627-859 2.7e-49 162.4 In-house 56-281 (290) alignment 
Range on Protein: 627-859
Range on HMM: 56-281/290.0
NLSKNRYRDITAYDITRVHLLDG-PVDYINANYVNMDIPstcqvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQ-GNSTE
.. ||||.|..  |.||| | || . ||. ||||.   .       .|.|||....| ||.|.|| ...  .|||| ...|.|| || .|.|.. |.   
efkknrykdvvcndktrvilkdGydGdyvhanyvkGlka......mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGPFQIYC-ESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTlrhgMEDPLVVHCSGGIDRSGIFVAMETALTKIEI
.| . . | |.| ||.    . . ...  .  |. . ||.   | .  |.| .  .|| .| | .    .  |.||||| || |.| |||.|..|  .  
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilld

VEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
  ....|..|| .|. |   .    ||  . . ...
Gkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 623-858 5.5e-49 161.7 In-house 24-265 (274) alignment 
Range on Protein: 623-858
Range on HMM: 24-265/274.0
KLPQNLSKNRYRDITAYDITRVHLL-----DGPVDYINANYVNMdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWP
... . .||||..|   . .|| |      |   .||||||.        .   |. ||||..||  |||.|.... .  |||||.. |. . || .|.|
dvfgsqtknryktilPnensrvllesessededssyinanyikG...ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

DQGNS---TEYGPFQIYCESDRKDNLCCTRHFVLKNNRTkeEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGME---DPLVVHCSGGIDRSGIF
|. .     .|| ..|  |.  . |    |..|||.     |. ..|  . || . ..|     .|....  .. |.  .    | ||||| || | |.|
daedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

VAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIV
.|.. |. ...  .  . |.||  .| .|| |. . .||..    ..
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 618-861 4e-48 159.0 In-house 41-279 (315) alignment 
Range on Protein: 618-861
Range on HMM: 41-279/315.0
LTIASKLpQNLSKNRYRDITAYDITRVHL----LDGPVDYINANYvnmdIPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCC
| .| |  .|  |||| .| ||| .||.|     |   ||.|||.    |.   .  ||| .|||  ..  |||..|.|. .| |||||...|. | |. 
ldvakki.enkqknryiniiaydksrvqlpllendphsdyvnanf....idGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkae

RYWPDQgnSTEYGPFQIYCESDRKDNLCCTRHFV-LKNNRTKEekpIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFV
.||||.     ||.. .   |. . .  . | .    ... .|   .. |..  | ...||     .. .||. .  ..    ..||||| |. |.| |.
kywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnire...vvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfi

AMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAY
.... | ..|. .| .  .... .|..|  |. ...||.|  | .....
tldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 619-860 5.3e-47 155.7 In-house 53-290 (319) alignment 
Range on Protein: 619-860
Range on HMM: 53-290/319.0
TIASKLPQNLSKNRYRDITAYDITRVHL--LDGP--VDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTdimeegKVKCCR
   . |.||  |||. .| |.| ..| |  |.|    ||||| .|.       .  .|| .|||..||  |||.|.||. |  ||.||      | ||..
qtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvt....GyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWPDQGNSTeYGPFQIYCESDRKDNLCCTRHFVLKN-NRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGME--DPLVVHCSGGIDRSGIF
||| ... . .. |..  .|  . .    |.. | .  . |. . |    || | .  ||   .|..|...... |.. ..   ..||||| |. |.|..
ywplkivik.eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy

VAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQA
..... | ...  .  .  ..|| .|.||  ..  | ||||    ... 
ivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 620-861 2.1e-46 153.7 In-house 18-255 (284) alignment 
Range on Protein: 620-861
Range on HMM: 18-255/284.0
IASKLPQNLSKNRYRDITAYDITRVHL--LDGP--VDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTdimeegKVKCCRY
  . |.||  |||. .| |.| ..| |  |.|    ||||| ...       .  .|| ||||..||  |||.|.||. |  ||.||      | ||..|
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfit....GyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy

WPDQGNSTeYGPFQIYCESDRKDNLCCTRHFVLKN-NRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGME--DPLVVHCSGGIDRSGIFV
|| ... . .. |..  .|  . .    |.. | .  . |. . |    || | .  ||   .|..|...... |.. ..   ..||||| |. |.|...
wplkivik.eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

AMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAY
.... | ...  .  .  ..|| .|.||  ..  | ||||    ... .
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_PTPRN_pd Subfamily PTPRN 620-859 2.8e-46 152.6 In-house 49-290 (297) alignment 
Range on Protein: 620-859
Range on HMM: 49-290/297.0
IASKLPQNLSKNRYRDITAYDITRVHLLD----GPVDYINANYVNMDIPstcQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRY
 ..| ..|..|||.... .|| .||.| .       |||||  .  . |   .   || ||||. .|  ||||||||||.  ||.|| . |||  .| ||
evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdp...rapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPDQGNSTeYGPFQIYCESDRK-DNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAM
|||.|... |. ...   |.    .    | | ||| .|.| . .  . || | |..||     .| | |..     |   |.|||||.|  |.|.....
wpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyili

ETALTKIE-IVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
.  |...   |   .    .  .||||  .. . .|..|   ....
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 626-859 3.9e-46 152.2 In-house 19-262 (270) alignment 
Range on Protein: 626-859
Range on HMM: 19-262/270.0
QNLSKNRYRDITAYDITRVHLL----DGPVDYINANYVNmdiPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGN
..   |||.||     ||| |     |    |||||||.     . .  .|| ..||...|  .||.|.||.    |||.|...|.|. || |||| . .
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvr...GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

S---TEYGPFQIYCESDRKDNLCCTRHFVLKnnRTKEEKPIIHLQFLDWSESNVPLVKA------DFLRFIRRLHTLRHGMED--PLVVHCSGGIDRSGI
.   .|.|  ..  .|..|..   ...  |.  .. ||. ..| .. .| .  ||  .       . |. .| ..  .. ...  ||.|||| |..|.|.
ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

FVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
..|...|.  .|  .  ..|.|.. .| .|  ..   .||.|    .|.
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 626-869 1.3e-45 150.8 In-house 50-292 (297) alignment 
Range on Protein: 626-869
Range on HMM: 50-292/297.0
QNLSKNRYRDITAYDITRVHLL----DGPVDYINANYVNMDIPstcqvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKvKCCRYWPDQGN
 |..|.||..|  ||  ||.|     |   ||.|| .|.          |.| || ||..|  |||.||...    ||||.|  |. | || |||.|.| 
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh......rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

STeYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPL--VKADFLRFIRRLHTLRHGMED-PLVVHCSGGIDRSGIFVAMETAL
.| .|   .  .|  . .    |.........| .. .   ||..| . .|.     . .| .|  ..    . .. ||.|||. |. | |......  .
tt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

TKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIEID
....  .. . ...|...|..|  .. . .||||    ...|   .  .|.
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 621-878 1.4e-45 150.5 In-house 38-297 (315) alignment 
Range on Protein: 621-878
Range on HMM: 38-297/315.0
ASKLPQNLSKNRYRDITAYDITRVHL---LDGP-VDYINANYvnmdIPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYW
... ..| .||||..|  .| .|| |    | |  ||||| |    |.|  .   || .||| . .  |||.||...    |||.|.  |. |.|| .||
varetinfkknryknilPldsarvkleviddsPdsdyinasy....iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PD-QGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNnrTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAME
|| ...|.|.| ...   |   |    .|..|...  ..| . .   || .| .  |.   . .|..|. . . ..  | .|.|||| |. |.|......
PdrkadsvefGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisid

TALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYE--EDY-IEIDLSNHANNVK
  . .|.  .. . ...|...|..|  .. . ..| |  | . .     .   . | ...| ....
evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 621-862 1.2e-43 144.0 In-house 33-278 (287) alignment 
Range on Protein: 621-862
Range on HMM: 33-278/287.0
ASKLpQNLSKNRYRDITAYDITRVHLLDGP---VDYINANYVnmdiPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWP
| .|  . .|||| |.  .| ||| |   .   .||||||||    .|  .  ..|..|||.  |  |||..|.|.    ....|  .||.. || .|||
aeel.aavkknryadvlPiddtrvllsaegelGsdyinanyv....asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

DQGNSTEYGPFQIYC-ESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRL----HTLRHGME-DPLVVHCSGGIDRSGIF
..      | . .   . | |.   ..| . | .  |.| . .  |..|.| .  ..     ..||.          | . |  |||||.. || ||||.
erevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil

VAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYE
.|. . . . | .   ..  .|  .| .|  .. |  |... .. .|  |.
latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 626-858 1.4e-43 143.9 In-house 2-236 (237) alignment 
Range on Protein: 626-858
Range on HMM: 2-236/237.0
QNLSKNRYRDITAYDITRVHLL--DGPVDYINANYVNmDIPSTCQvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGNST
.|  |||| .|.||| .|| |    . .|||||.|.. ..  | .  .|| .|||....| |||||||.. |  ||||| ..|  ..|| .|||.  . .
enkiknrygnivaydhsrvvlkgagsgsdyinatylk.gfdgtpk..kyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

EYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIH-LQFLDWSESNVPLVKADFLRFIRRL-HTLRH-GMEDPLVVHCSGGIDRSGIFVAMETALTK
 || . .    . .      | ..| .. |..|  .||  ||  | .  ||   | .||| ... .  .|     | ..||| |. |.|||. ... | .
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

IEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIV
 .  .  .  . |  . ..|  .. . .|| |  . |.
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 626-859 4.6e-43 142.1 In-house 42-274 (515) alignment 
Range on Protein: 626-859
Range on HMM: 42-274/515.0
QNLSKNRYRDITAYDITRVHL---LDGP-VDYINANYvnmdIPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPD-QG
 | .||||..|  || .|| |    | |  ||.|| |    |||      || .||| . .  |||..|...    |.|.|.  |. |.|| .||||  |
infkknryknilPydsvrvklevindnPhsdyfnasy....ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

NSTEYGPFQIYCESDRKDNLCCTRHFVLKnnRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETALTK
.| ..| ...   |   .     |.. .   . .. . .   .| .| .  ||     .|..|. . . .  .. ||..||| |. | |......  ...
dsvkfGsikvelvsleactggikrkltvl..kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvah

IEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
..  .. . ...|. .|..|  .. . .|| |  . . .
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle
0041856 (Phosphotyrosine protein) phosphatases II 627-865 1.4e-42 140.7 In-house 1-175 (182) alignment 
Range on Protein: 627-865
Range on HMM: 1-175/182.0
NLSKNRYRDITAYDITRvhlldgPVDYINANYVNMDIPSTCqvvrYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTdimeegkvkCCRYWPdqgnsteyg
||.||||.||  || .|      . ||||||.. .. |.|     .|.||||...|. ||..|..|.|.. ||.||         ...|||         
nldknrysdilpydhsr......dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

pfqiycesdrkdnlcctrhfvlknnrTKEEKPIIHLQFLDWSESNVPLvKADFLRFIRRLHTlrhgMEDPLVVHCSGGIDRSGIFVAMETALTKieiveA
                          ...|. .|....| |   .||    ..|.||.. .      . | .||||.|..|.| .||.   ...      
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

FNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDY
... |.|...| .| .|   .||| |  ... . .. ..
vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
0051429 (Phosphotyrosine protein) phosphatases II 652-862 5e-41 136.5 In-house 5-226 (272) alignment 
Range on Protein: 652-862
Range on HMM: 5-226/272.0
DYINANYVNMDiPSTCQVVRYIVTQGPMQNTCIDFWQMvWEQGCGFIVMLTDIMEEGKVKCCRYWP-----------DQGNSTEYGPFQIYCESDRKDNL
.||||..|..   ..    |.. ..||...|. |||.. .|.|.  ||.|.. .| |..|| ||||           |   . .|| . ... |    . 
gyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

CCTRHFVLKNN-RTKEEKPIIHLQFLDWSESNVPLvKAdFLRFIRRLHTlrhgmEDPLVVHCSGGIDRSGIFVAMETALTKIEIVEAFN--------PLE
.  |...|..   ..|   . ||...||   .||  .| .|.... |..     . |..||||.|.||.|..||.   |  ..    ..        ..|
yilrellltlllsagearevmhlhytdwpdhgvpq.ea.llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

IVRMMRDQRGMMLPALNQYKFFCDCIVQAYE
.|...|.||  . .   ||.| .........
aveelraqrpgavqteeqylflyeallellr
subfamily_CG7180_pd Subfamily CG7180 626-860 7.1e-41 134.8 In-house 41-289 (296) alignment 
Range on Protein: 626-860
Range on HMM: 41-289/296.0
QNLSKNRYRDITAYDITRVHL--LDGP--VDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKvKCCRYWPDQGn
.|. |||. ..  || .|| |  |||    ||||| ||.    |  .   ||||..|...|  .||..|.....  .|.||. ..  | ..  ||| .. 
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvd....sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.

STEYGPFQIYCESDRKDNLCCTRHFVL-KN---------NRTKEEKPIIHLQFLDWSE-SNVPLVKADFLRFIRRLHTLRHGM-----EDPLVVHCSGGI
 ..||.. .   . ..     .| | | |.         . . |.. . ..|.  |    .|||. . .. ..|| ...|. .     | |.||..| | 
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

DRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQA
 |||...|.. .| ..|. | ..  | |...| .|  ..   ..||.  | . .|
sRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 607-859 4.5e-40 132.4 In-house 26-277 (439) alignment 
Range on Protein: 607-859
Range on HMM: 26-277/439.0
FDRLYRKKPGMLTIASKLPQNL--SKNRYRDITAYDITRVHLLDGP----VDYINANYVNMDIpstcQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVM
|. .   .|    ||| . |.   .||||.|..|.| ||| | . |      ||||||..       .   || |||| ..|. |||..|.|. .  |||
fekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy....ddklyiatqgpkkettddfwrlviekktvtivm

LTDIMEEGKvkccrYWPDQGNsTEYGPFQIYCESDRKDNLCCTRHFVLKNNR--TKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGME-DPL
||...|  |     ||| ... . ||   . .. . .    . | | . |.|  |. |. ....... | . |||   .  | |.| . .     |  |.
ltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpv

VVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
||||| |. |.|  .|.. || .. . .  .   ||...|.||  |. || || |  .....
vvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 619-872 5.8e-39 129.1 In-house 40-299 (325) alignment 
Range on Protein: 619-872
Range on HMM: 40-299/325.0
TIASKLPQNLSKNRYRDITAYDITRVHLL----DGPVDYINANYVNMDIPSTCqvvrYIVTQGPMQNTCIDFWQMV--WEqgCGfIVMLTDIMEEGKVKC
  .. .|.| .|||.... |.| .|| |     |.  |||||.|.. |.        .. .| |. .|  |.|..|  |.  |  .|........|| .|
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdv....flaaqaPltatindlWrlvldWr..cs.vvvvlneldlgkdrc

CRYWPDQ-GNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSE---SNVPLVKADFLRFIRRLHTLRHG---MEDPLVVHCSGGI
. |||.. |.| ..|....   .  .      | . .|. .  | . .  .|.  | .    . |   . .|. .  ..   .       |..|||| |.
avywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGv

DRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIEIDLSN
 |.|.|... .|| |.      . .. |. .| .|  |. . .|| .  ...|.||     .. .|.
GrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvss
0036282 (Phosphotyrosine protein) phosphatases II 652-854 4.6e-38 126.0 In-house 3-163 (174) alignment 
Range on Protein: 652-854
Range on HMM: 3-163/174.0
DYINANYVNMDIPSTcqvvRYIVTQGPMQntcidFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDqgnsteygpfqiycesdrkdnlcctrhfvlknN
|||||..... . ..    |.|..|||..     ||.|..|.|.  .|||.. .| |..||..|||.                                .
dyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................l

RTKEEKPIIHLQFLDWSESNVPLVKAdFLRFIRRLHTLRHG-MEDPLVVHCSGGIDRSGIFVAMETALTKIEiVEAFNPLEIVRMMRDQRGMMLPALNQY
|. .|. .|....| |   .|| .   .|.|...... .    . |..||||.|..|.|..||.   |. ..   . . |..||..| ||..| .  .||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

KFFC
.|  
rfly
0046846 (Phosphotyrosine protein) phosphatases II 643-858 5.8e-38 125.7 In-house 4-170 (176) alignment 
Range on Protein: 643-858
Range on HMM: 4-170/176.0
RVHLLDGPVDYINANYVNMDipstcqvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDqgnSTEYGPfqiycesdrkdnlcc
|.. ||...||||||.. ..        |.|.||||. .|. ||..|..|.|.. .|.||. .| |..||..|||.    ...|                
rllgldldldyinanlilgs........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi...............

trhfvlknnrtkeekpiiHLQFLDWSESNVPLVkADFLRFIRRLHTLRHGMeDPLVVHCSGGIDRSGIFVAMEtaL--TKieivEAFNPLEIVRMMRDQR
                  . ..|.| . .||   ...|.... ... ..    | .||||.|| |.| .||.   |  ..      ....|.....|.||
..................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay..llele....kglsveealalvreqR

G-MMLPALNQYKFFCDCIV
  ....  .||.|  ... 
plgavqtpeQyrflyefel
0049772 (Phosphotyrosine protein) phosphatases II 618-860 1.4e-36 122.2 In-house 37-279 (314) alignment 
Range on Protein: 618-860
Range on HMM: 37-279/314.0
LTIASKLPQNLSKNRYRDITAYDiTRVHLlDG----PVDYINANYVNMDipstcqvVRYIVTQGPMQNTCIDF----------WQMV--WEQGCGFIVM-
 . ...|. | .|||| ||  .| .||.| .|     .|||||.||.          ..|.||||...|..||          |.||  ... .  ||| 
tilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------LTDIMEEGkvkccrywpDQGNSTEYGPFQiycesdrkdnL-------CctrhfvlknnrtkeEKPIIHLQFLDWSESNVP
                    |..... |         .. .  ..  ..                  .              |...|..  ....  ..|
rdevladelsrLdaAlgKtpllildgng.........neptaadlellk..........eelydpelf..............erlgikylripvpDgsap

lVKADFLRFIRRLHTLrhGMEDPLVVHCSGGIDRSGIFVAMETALTKIeiveAFNPLEIVRMMRDQRG-----MMLPALNQYKFFCDCIVQA
   .||..|.. ....    . |..|||..|..|.| ||..   . .      ... |.....| .|       ... |.|| |  ... ..
.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 608-783 1.1e-35 118.0 In-house 14-190 (297) alignment 
Range on Protein: 608-783
Range on HMM: 14-190/297.0
DRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLDGPV--DYINANYVNmdIPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIM
| |.... |    ..| .  | ||||||| |.| |||.|| ..   |||||.||    |   . ..||..|||...|  |||..|.||. . |||.. . 
dllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvv..fpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklq

EEGKVKCCRYWPDQG-NSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFI
|.|. ||  |||.   .  . | . .   |.  |.        |.    .|.. . | ||| | .  ||    |  || 
edGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfq
0043147 (Phosphotyrosine protein) phosphatases II 650-854 1.5e-35 117.8 In-house 4-154 (172) alignment 
Range on Protein: 650-854
Range on HMM: 4-154/172.0
PVDYINANYVNMDIpstcQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDImeegkvkccrywpdqgnsteygpfqiycesdrkdnlcctrhfvlK
. |||||.|... .       |.|.||||..||. |||.|..|.|.. ||.||.                                              
gsdyinasyldlyy....ipdrfiatqgplrntladfwrmlkelgithivnltel............................................l

NNRTKEEKPIIHLQFLDWSESNVPlVKADFLRFIRRLHT-LRHGMEDPLVVHCSGGIDRSGIFVAMETALtkieivEAFNPLEIVRMMRDQRGMMLPALN
......|. .|....| |   .||   . .|.|.. ... |    . | .||||.|..|.| .||.   |      . ....|.|...|..|... .  .
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYKFFC
||.| .
qyrfly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 627-867 1.5e-33 110.7 In-house 55-295 (305) alignment 
Range on Protein: 627-867
Range on HMM: 55-295/305.0
NLSKNRYRDITAYDITRVHLLD-GPVDYINANYVNMDIpstCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPD-QGNSTE
. .||||.|. . | . |.| .  |.||| ||||   .       |.|..|||...|  .|| || ..    ||||   .| ||.||..|||  ||.  |
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpm...ipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

YGPF-QIYCESDRK--DNLCCTRHFVLKNNR-TKEEKPIIHLQFLDWSESNVPLVKADFLRFirrLHTLRhGMEDPLVVHCSGGIDRSGIFVAMETALTK
      .   |  |  .     .  .|. .   ...  . |||. .| .  || .|   | .   | ..| | . |.||||| || |.|  ||.|  | |
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslel...lsair.gskvpivvhcsagigrtgtivaieyilek

IEIVEAFNPL-EIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIE
|       |. |.|. .|||| . . .  || |    ... . | | |
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke
0049260 (Phosphotyrosine protein) phosphatases II 667-854 1e-32 108.3 In-house 6-143 (152) alignment 
Range on Protein: 667-854
Range on HMM: 6-143/152.0
CQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWpdqgnsteygpfqiycesdrkdnlcctrhfvlknnrtkeekpiiHLQFLD
 .  ..| ||||. ||. |||.|..|.|.. |||||. .| ||.|| .|.                                            . ..| 
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlp

WSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETALtkieivEAFNPLEIVRMMRDQRGMMLPALNQYKFFC
|  ..||     .| ... .. |..  . | .||||.|..|.| .||.   |        ....|.|...| .| .. |  .|..|  
wpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 606-867 1.1e-32 108.3 In-house 21-283 (307) alignment 
Range on Protein: 606-867
Range on HMM: 21-283/307.0
SFDRLYRKKPGMLTIASkLPQNLSKNRYRDITAYDITRVHL-LDG-PVDYINANYVNMDIpstcQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTD
 |  | .|.|  .|. . .  |  ||||.|. . | .|. . .||   ||| |||. . |    .  ..|..|||..||  .|| |. ..    ..|| .
efrvlakktpegvtvea.fsantdknryqdvkcqdkgrivvkfdglasdyihanylgiai....kpkkficaqgplentqysfwamaiqekvesvimlck

IMEEGKVKCCRYWP-DQGNSTEYG--PFQIYCESDRKDNLCCTRHFV----LKNNRTKEEKPIIHLQFLDWSESNVPLVKadfLRFIRRLHTLRhGMEDP
..| .|.|| .||| ..|.   .|  |  |  .    ..|.   ...    || . ... . | |||. .| .  || ..   |  |  |.. | . ..|
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin...ltainlleavr.ydtnp

LVVHCSGGIDRSGIFVAMETALTKI-EIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIE
.||||| |. |||  ||.     |. . ..  .  ..|. .|.||   . .  || ..   ... . | | |
vvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyke
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 607-858 1.4e-32 107.6 In-house 21-290 (301) alignment 
Range on Protein: 607-858
Range on HMM: 21-290/301.0
FDRLYRKKPGMLTIASKlPQNLSKNRYRDITAYDITRVHLLDGPV------DYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVM
...|.....   |.  .  .|   ||...|| ||  |. |   |       .||||.|..    .. .  ..|..||||..| .|||...|..    |||
ykelkegedksctvgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyid....gysekkkfiaaqgpmkktlvdfWrliwqekpvsivm

LTDIMEEGKVKCCRYWPD-QGNSTEYGPFQIYCESDR-----------------KDNLCCTRHFVLKNNRtkEEKPIIHLQFLDWSESNVPLVKADFLRF
.|.  |. | || .|||. . .|.|.|||..   ..                   .|    |.|  |...  . . .. ||  || .  |   ..  |. 
vtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqv

IR-RLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIV
|   .|. .     |.||||| .. |||...... .|         .  .... .| ..  .   |.|| .  | | 
iddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 605-859 2.1e-32 107.3 In-house 19-269 (288) alignment 
Range on Protein: 605-859
Range on HMM: 19-269/288.0
VSFDRLYRKKP--GMLTIASKLPQNLSKNRYRDITAYDITRVHLLDGPVDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLT
 . .. ||  |  .   |...  .| ...||...   |||||.| | |  ||.|| |     |.    | | .| |.. |   .|.|. |..  .||||.
eglkkeyrdspneasidiidsfianptrdryenlprcditrvklsddpdfyiaanvvs....sakykrrlicaqaPlngtieelWkmllesdveyivmlc

DIMEEGKVKCCRYWPDQ-GNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKP-IIHLQFLDWSESNVPlvkADFLRFIRRLHTLrHGMEDPLVVH
...| || |   |.| . |... .| .      .|.|     .  .|..... |||  . .| .|.| .  ||    ..| ..| |. | . .. |.|||
ellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvP...enylsplrllevl.kslqkPivvh

CSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
.| |. |.| .. .  ||. . ...     ...  .|..|   . . .|| ..  |. .
ssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 624-857 5e-32 106.0 In-house 4-236 (239) alignment 
Range on Protein: 624-857
Range on HMM: 4-236/239.0
LPQNLSKNRYRDITAYDITRVHLL----DGPVDYINANYVNmDIPSTCQvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQ
   | .|||| .| .|| .|| |     |   |||||.|.  |   . .   || ||| .. .. |||.|.|..    ||||| ..|  | || .|||| 
krvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspk..ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

gnSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETALT
  ...|  ...             | ||. .    ||. . . .|  | .  ||   .  | . |..         | |.||| |. |.| |. ... | 
..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

KIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCI
. .  .. . .. |. .|..|  |. . .|| |   ..
qakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 623-853 6.3e-32 105.6 In-house 4-233 (239) alignment 
Range on Protein: 623-853
Range on HMM: 4-233/239.0
KLPQNLSKNRYRDITAYDITRVHLL----DGPVDYINANYVNmDIPSTCQvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPD
|   | .|||| .| .|| .|| |     |   |||||.|.  |   . .   || ||| .. .. |||.|.|..    ||||| ..|  | || .||||
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspk..ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

QgnSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETAL
   ...|  ...             | ||. .    ||. . . .|  | .  ||   .  | . |..         | |.||| |. |.| |. ... |
s..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

TKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFF
 . .  .. . .. |. .|..|  |. . .|| | 
rqakkqktvdifnyvkairedrphmvqtseqyvfi
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 613-851 1e-31 104.7 In-house 39-280 (310) alignment 
Range on Protein: 613-851
Range on HMM: 39-280/310.0
KKPGMLTIAsKLPQNLSKNRYRDITAYDITRVHLL-DG--PVDYINANYVNMDIPSTCqvvrYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGK
|.   ||      ... |||| |.   | .||.|  |     ||| ||||. .   .     .|..|||.| | ||||.|.... .  |..|  ..|||.
kqdssltye.aykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrst....ficsqgplqhtiidfwrmifqeraesilllckvgeegr

VKCCRYWPDQGNSTEYGPFQIY--CESDRKDNLCCTRHFVLKNNRTKEEKPI-------IHLQFLDWSESNVPLVKADFLRfIRRLHTLRHGmedPLVVH
 ||  |||  | .  ||  ..   .||  . ..|      . .|   .|.|          ... .| .  ||  |   .   | |  .|||   | |||
pkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrllaqvrhg...pcvvh

CSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYK
|| |.|| .. ||.. .. |..  .  .  |..  .. .| .   .  || 
csagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 621-859 1.2e-30 101.2 In-house 39-234 (392) alignment 
Range on Protein: 621-859
Range on HMM: 39-234/392.0
ASKLPQNLSKNRYRDITAYDITRVHL--L-DGP-VDYINANYvnmdIPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGkvkccryw
... . || ||||..|  || .||.|  . | |  ||.|| |    |||  .   || .|||   .  |||.||...    |.|.|.. |          
vaqkeinlkknryknilpydsarvkleviddipdsdylnasy....ipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd........

pdqgnsteygpfqiycesdrkdnlcctrhfvlknnRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTlRHGM-EDPLVVHCSGGIDRSGIFVAME
                                   . .. . .   .| .| ...||   . .|.||. ...  .|    ||..||| |. |.|. ....
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevka.dfGqythpliihcsagvgrtgvvisid

TALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
. ... . .   . ...|  .| .| .|. . .|| |   ....
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 623-863 7.1e-30 98.8 In-house 44-289 (305) alignment 
Range on Protein: 623-863
Range on HMM: 44-289/305.0
KLPQNLSKNRYRDITAYDITRVHLLD-GPVDYINANYVNmdIPSTCQvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGN
|  |.  ||||.|.   |  ||.|    | .|| ||||    |.  .  |.| || |...|| ||| | ...    | || ...| |  ||. |.. . .
keaqeagknrykdvgcldnnrvklegpwpheyihanyvs..tptnpk..rfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdk

S-TEY---G-PFQIYCESDRKDNLC------CTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLhtlRhGMEDPLVVHCSGGIDRSGI
   |.   |   .. .||  . ..        |.  .. .   .. . . |  . || .  ||      | .. .    |     |.||||| || |.| 
dvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka...r.pskgpivvhcsagigrtgs

FVAMETALTKIEIVEAFNPL-EIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEE
 | .|  | ..   .  .    |.. .|.||   . . .|| |  . |.. ...
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 607-824 9e-30 98.3 In-house 17-230 (281) alignment 
Range on Protein: 607-824
Range on HMM: 17-230/281.0
FDRLYRKKPGMLTIASKLPQNLSKNRYRDITAYDITRVHLLD-----GPVDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVML
|  |    |  |  . . | |  |||| .| . ||.||.|          ||| |||.     |      ||.|||| ..|  |||.|.|..    ||||
fsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyir....spflkrgyiltqgpkketradfwrmiwqenttaivml

TDIMEEGKVKCCRYWPDQGNS-TEYGPFQI-YCESDRKDNLCCTRhfvLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTlrhgMEDPLVV
 ...|  . ||. |.| .     ..  . . | .|  .  |  ||   |.     | . | |  . .| . .||     .|. .|....       | |.
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr...lnlsyegetrlithwlwkewpdwqvpessevmlkilrkira....rstppvi

HCSGGIDRSGIFVAMETALTKIEIV
||| |. ||| ..|.| ||  |   
hcsagvgrsgtlmaveialqsihsh
0051082 (Phosphotyrosine protein) phosphatases II 651-855 2.5e-29 97.2 In-house 3-147 (151) alignment 
Range on Protein: 651-855
Range on HMM: 3-147/151.0
VDYINANYVNMDipstcqvvrYIVTQGPMQntciDFWQMVWEQGCGFIVMLTDIMEEGkvKCCRYWPDQGnsteygpfqiycesdrkdnlcctrhfvlkn
.||||..||            .....||..    ||.....|.|.  ||.|.. .| |  .| .|.|..|                              
sdyinfsyvtgg.........lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..............................

nrtkeeKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTlrhgM-EDPLVVHCSGGIDRSGIFVAMETALTKieiveaFNPLEIVRMMRDQRGMMLPALNQ
        ..|...|||.. ..||  . .|.|.. |      . . |..||||.|..|.|..||.   | .      ... |.....| .|...    .|
......ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

YKFFCD
. |   
flfqlf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 629-843 2.2e-28 93.9 In-house 52-263 (301) alignment 
Range on Protein: 629-843
Range on HMM: 52-263/301.0
SKNRYRDITAYDITRVHLL-DGPVDYINANYVNMDipstCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPD-QGNSTEYG
 |.||  .     | |... ||    | ||... .     .  |.|.||||..||. ||| |.       ||||.  .|. . ||  | |   ... . |
dkhryptvPckPstavevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

PFQIYCESDRK--DNLCCTRHFVLKNNRTK-EEKPIIHLQFLDWSESNVPLVKADFLRfirrLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETALTKIEI
 |.|  ..  .  ..    |.. ...   | . . ..| |. .|.. .||  .|.       |  |    |.|.||||| || ||  |.. |    ..| 
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfd....lmelvkksekPivvhcsaGiGrsvafigteylarevea

VEAFNPLEIVRMMRDQRGMM
    .  | .. .|..|   
dptieltealkhlrehrwng
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 617-857 4.1e-28 93.1 In-house 22-255 (267) alignment 
Range on Protein: 617-857
Range on HMM: 22-255/267.0
MLTIASKLPQ-NLSKNRYRDITAYDITRVHLLDGPVDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEgKVKccRY
  ||.  ... |  .||. |   || ||| | .   .|||| ||.    .  .   .||||.|..||  ||.... .|..  ||.|| . .. ...  ..
sstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyve....gyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd.nir..lf

WPDQ-GNSTEYGPFQIYC--ESDRKDNLCCTRHFVLKNNRTKEeKPIIHLQFLDWSESNVPLVKADFLrfIRRLHTLRHGmEDPLVVHCSGGIDRSGIFV
|| . |.. .|  . .    | . .|    |  . .||. ...   . . .  .    | | .|  |   |     |  | . ||||.|| |. ||| |.
wPPkmgqakkyqdltvehslekeendyqiitlelkfknesahn.vtlyyykkwnintnnkpylkplfg..ilaknqleng.nrPlvvacsdGvGrsGtfl

AMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCI
 ... | ..   .  .  . .| .|.||  .. ....| .  . .
vidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
0044763 (Phosphotyrosine protein) phosphatases II 649-857 1.5e-27 91.8 In-house 16-167 (178) alignment 
Range on Protein: 649-857
Range on HMM: 16-167/178.0
GPVDYINANYVNMDipstcqvvRYIVTQGPmqntcIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGNsteygpfqiycesdrkdnlcctrhfvl
  .|||||...  .         |. ...|      |......|.|.. ||.||. .| |..||..|||.. .                           
ersdyinaseilpg........lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...........................

knnrtkeekpiIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETALTKieiveAFNPLEIVRMMRDQRGmMLPALN
           |. ... .. ..|| . . ||.|.. ......  . | .|||| |..||| .||.   ..       ... |.....| .|  . |  .
...........iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg

QYKFFCDCI
|... ... 
qlrqLyefe
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 627-853 3.1e-27 90.3 In-house 35-262 (285) alignment 
Range on Protein: 627-853
Range on HMM: 35-262/285.0
NLSKNRYRDITAYDITRVHLLDGPVDYINANYVNMdiPSTCQVvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQ-GNSTEY
|   ||| |. . . ||| | .   ||| |... |  |   |   || ||||. .|  |||.|....   ...||  ..| |  ||. |.|.. |.  ..
npdlnryadvrcieetrvvlknhdrdyihaswmrm..pgkdqs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

GPFQIYCESDRKDNLCCTRHFVLKN----NRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLrHGMEDPLVVHCSGGIDRSGIFVAMETALTKI
| ..|     ... .. |    |      . . |   . |.|   | .   |     .. . . .. .    | |..|||| |. |.  || .. |  .|
gkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrtatfvgidyatiri

EIVEAFNPLEIVRMMRDQRGMMLPALNQYKFF
      . |.||| ||  |   . .  |. |.
menpniemldivremramrfqavqshmqflfl
subfamily_ptpA1_pd Subfamily ptpA1 626-820 1e-25 85.4 In-house 46-255 (418) alignment 
Range on Protein: 626-820
Range on HMM: 46-255/418.0
QNLSKNRYRDITAYDITRVHLLD----GPVDYINANYVNMDIPStcqvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGN
.| ||||| .|   . |||.|         |||||||..   |      ..|.||||. ||  |||.||||. |  ||||.   |. ..|| ||||.|  
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.....qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

STE---YGP----FQIYCESDRKDNLCCTRHFVLKNNRT---KEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRH------GMEDPLVVHCSGGI
  .   ||     |  |     .      |  . .| |     | . | . |.  | . |.|     | .... .   .         . |..|||| |.
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

DRSGIFVAMETALTK
 |.| |..    . |
grtgtfctavimmkk
subfamily_egg_pd Subfamily egg 626-858 3.5e-25 83.3 In-house 39-267 (307) alignment 
Range on Protein: 626-858
Range on HMM: 39-267/307.0
QNLSKNRYRDITAYDITRVHL--LDGP--VDYINANYVNmdipSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEgkVKCCRYWPDQGN
 || | | . .   | .||.|    |    |.| ||.|.        .  .|..| |..||  |||.||... . .|||||   |    .|  |||   .
nnlekarskrvhckdssrvklelrrGqylddfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaes

-STEY--GPFQIYCES--DRKDNLCCTRHFVL-KNNrtKEEKPIIHLQFlDWSESNVPLVKADFLRFIRRLhtlrhgmEDPLVVHCSGGIDRSGIFVAME
 |  .  | ..| .    .. | |    .. |   .  .||. . | |  |. .|.        || .|.|         | ||..  |. ... .||.|
dslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqg.dvnnssdvysplrvlrklrnl.......skpvvvqdilGvskaatlvaie

TALTKIEI--VEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIV
.|| ..    .  .  |. | ..| .| . . .  .| |    ..
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 670-853 4.1e-24 79.9 In-house 4-195 (198) alignment 
Range on Protein: 670-853
Range on HMM: 4-195/198.0
VRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGNS-TEYGPFQIYCESDRKDNLCCTRHFVLKNNRTK--EEKPIIHLQFLD
 |||.|| |...|  |||||||| | | |||. |   . ..    |||   .. ..|| . . ...       .   ..| || |     . | | ||  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WSESNVPLVkADFLRFIRRLHTL----RHGMEDPLVVHCSGGIDRSGIFVAMETALTKIEIV--EAFNPLEIVRMMRDQRGMMLPALNQYKFF
| |   | | | |. |.     .        . |..|||| |   .|.|||..  .   |       . .|. . .|. |  .. .|..|.| 
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 670-853 4.4e-24 79.8 In-house 5-196 (199) alignment 
Range on Protein: 670-853
Range on HMM: 5-196/199.0
VRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGNS-TEYGPFQIYCESDRKDNLCCTRHFVLKNNRTK--EEKPIIHLQFLD
 |||.|| |...|  |||||||| | | |||. |   . ..    |||   .. ..|| . . ...       .   ..| || |     . | | ||  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WSESNVPLVkADFLRFIRRLHTL----RHGMEDPLVVHCSGGIDRSGIFVAMETALTKIEIV--EAFNPLEIVRMMRDQRGMMLPALNQYKFF
| |   | | | |. |.     .        . |..|||| |   .|.|||..  .   |       . .|. . .|. |  .. .|..|.| 
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 630-860 4.6e-24 79.7 In-house 46-275 (312) alignment 
Range on Protein: 630-860
Range on HMM: 46-275/312.0
KNRYRDITAYDITRVHLLDGPVDYINANYVNMdipsTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGNSTEYGPFQ
 ||| .|  .|  |  |      || ||.|..      .  |...||||..|||  |||..   |.  |..|. ..|.|  ||..|  |     .    .
lnrypniqcwdrgrftlagdenfyihanfvki....ctkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

IYCESDRKDNLCC-----TRHFVLKN--NRTKEEKPIIHLQFLDWSESNVPLVKADFLrfirRLHTLRHGMEDPLVVHCSGGIDRSGIFVAMETALTKIE
.| |.  . ..         | |||   . | .|  . | |.  | .  .|      |    || .  .    |.. ||| |. |.| .. .|. .. . 
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtal....rllsavkkdkkpviahcsagvgrtgtlaliesmiaalr

IVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQA
     |  ..  ..| .|   . .. || .   |... 
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
PTPc_DSPc_SM00012 759-858 5.1e-23 76.6 In-house 2-104 (105) alignment 
Range on Protein: 759-858
Range on HMM: 2-104/105.0
IIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGME--DPLVVHCSGGIDRSGIFVAMETALTKIEIV-EAFNPLEIVRMMRDQRGMMLPALNQYKFFCD
. |.....|.. .||    ..|...| ... ..  |   |.||||| |..|.|.|||....| ..|   . .. ..||...|.||  |   ..|| | ..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CIV
.. 
all
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 626-752 9.7e-23 75.4 In-house 46-181 (350) alignment 
Range on Protein: 626-752
Range on HMM: 46-181/350.0
QNLSKNRYRDITAYDITRVHLL------------DGPVDYINANYVNMDIPSTCQV--VRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVK
.  .||||..|  |. .||.|               . |||||||...  .|  .    .|| ||.|...|  ||.... . .   |..||. .| .  |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CCRYWPDQGNSTeygpFQIYCESDRkDNLCCTRHFVLKNNR
| |||.. . .     ...  .| . .| . ..  .|    
cyrYWqegsydd....itvklaskw.enimgindsslysad
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 652-858 1.7e-22 74.9 In-house 47-256 (290) alignment 
Range on Protein: 652-858
Range on HMM: 47-256/290.0
DYINANYVNMdiPstcQVVRYIVTQGPMQNT-------CIDFWQMVWEQGCGFIVMLTDIMEEGKV----KCCRYWPDQ-GNSTEYGPFQIYCESDRKDN
||| ||.| .  |   . .| |.|| | ...         .|| |. .     .||| . .|. .      | .| |.. |..  .. ... | |  |..
dyiHAnrvtc..p...nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskeked

LCCTRHFVLKNNRTKeEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHtlrhGMEDPLVVHCSGGIDRSGIFVAMETALTKIE-IVEAFNPLEIVRMMRD
   ||. |.| .  . |  . | .. .|...||.  .  .|  |. ..      . | .|||  || || .. |.. .  ||    ....  ... ..| 
dvetRelvvkfddee.eftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

QRGMMLPALNQYKFFCDCIV
|| ...   ... |    ||
qralaitsalelafvdagiv
FERM_M FERM central domain 128-236 1.3e-21 67.3 Pfam-A 1-125 (126) alignment 
Range on Protein: 128-236
Range on HMM: 1-125/126.0
DPVFLVEELTRYLFFRQIKKDLLENRLICPTEAAAILSAFALQAELGDYD-PVGHPPGYVSE-F-R-----FIS--------NQDEVFEKRVSEIHQEIR
||. . .| ...|.. |.|.|||| || |..| |. | | .||.|.||.. .  .. ... .   .     ...        .. . .|.|..| |....
dpnpkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknva

GQTTSEAEYNFLQYARQLEFYGVEQ
|.. .||....|| |..|. |||. 
glslaeaklkylqaaqslpdyGvsl
subfamily_CG42327_pd Subfamily CG42327 651-781 7e-21 69.2 In-house 56-185 (319) alignment 
Range on Protein: 651-781
Range on HMM: 56-185/319.0
VDYINANYVNMDIPSTCQvvrYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQ---GNSTEYGPFQIYCESDRKDNLCCTRHFV
  |..|.||     . ..   || .| .....  |||..||||    || |||. | |  .| .|.| .    |   || ...       ..   .  ..
deyldasyvrGyddapns...yiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistll

LKNNRTKEEKPIIHLQFlDWSESNVPLVKADFLR
||.   .| ... |  . .| |..||  .| .. 
lkrvdkeesrelthywy.kwleaevPaeeaalia
FERM_N FERM N-terminal domain 49-125 8.4e-21 64.1 Pfam-A 1-79 (80) alignment 
Range on Protein: 49-125
Range on HMM: 1-79/80.0
ITLLDDSMFTCDLNKHSLGSTLLDEVYAHADIIERDYFGLSY--SENGYNKWLQSDKPLKKQFKGGSCSVVLELRVKFY
..|||............ |. ||..| ... ..| .||||..   ... ..||. || |..|..  . ...| ||||||
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgveegkpttlllrvkfy
subfamily_eak_pd Subfamily eak 627-784 8.2e-20 65.4 In-house 52-205 (332) alignment 
Range on Protein: 627-784
Range on HMM: 52-205/332.0
NLSKNrYRDITAYDITRVHLLD---GPVDYINANYvnMDIPSTCQvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQG-NS
.. .|   .|  ||   |.|      .  ||||    .. .   .  .||.|  . ..    ||||| ||    ||.| . .|..  |  .|.||.. . 
avnrn.vvkivpydrylvrltssqlnrlGyinasl..aefsevGr..kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

TEYGPFQIYCESDRKDNLCCTRHFVLKNnrTKEEKPIIHLQFLDWSESNVPLVKaDFLRFIR
 ..| ... . .  | |   || ..|.     | . . | ..  |.| ..| .. ||| . .
lkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpkye.dflalrk
0048076 (Phosphotyrosine protein) phosphatases II 715-857 9e-20 66.3 In-house 2-139 (145) alignment 
Range on Protein: 715-857
Range on HMM: 2-139/145.0
YWPDQGNSTE-YGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHGmEDPLVVHCSGGIDRSGIFVA
|||..      .|..   .. ..  .|  |. . | .... .|. .|....|.|   .||   ...|.|.. .....   . | .|||| |..|.| .||
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.ggpvlVHCsaGvgRtgtlva

METALTkieivEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCI
.   |.     . ... |.....| || .. |  .|..| ....
aylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 682-820 1.6e-18 61.8 In-house 40-174 (255) alignment 
Range on Protein: 682-820
Range on HMM: 40-174/255.0
TCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQ-GNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFL
|   |.|..  ..   .|||.|  |||..|| .|.| .  .   .   .. .     | .  |.. ...  . |. . . | ..  | | | |    . |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

RFIRrlhTLRHGmeDPLVVHCSGGIDRSGIFVAMETALTK
  ..     |.    ..||||| || ||  || .| .  |
nilk...vvrds..ksvvvhCstGiGrsaafvlaelvyqk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 609-854 1.9e-18 60.9 In-house 34-278 (302) alignment 
Range on Protein: 609-854
Range on HMM: 34-278/302.0
RLYRKKPGMLTiASKLPQNLSKNRYRDITAYDITRVHLLDGPVDYINANYVnmDIPSTCqvVRYIVTQGPMQNTC---IDFWQMVWEQGCGFIVMLTDIM
..   |  .    .   .||.||.  |. ..| ..| |   | .|.||  |  ..|.       |..| | ...     .||.||... .  .|.|    
kidtmkvdlek.Ckafkknlkknqsedvpildsnlvkleaepdsyvnaskv..evPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgee

EEGKvKCCRYWP-DQGNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLD-WSESNVPLVKADFLRFIRRLHTLRHGMEDPLVVHCSG
|  |     ..|  .|. .||| . .      | .   ||  .        . ... .. |. | ...||   |.  . .  ....    ....|.    
elkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSkn

GIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFC
|. | |.|... .|..|..  .. |  |||. .| ||  .. .|.|| .  
GaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvsly
0048179 (Phosphotyrosine protein) phosphatases II 750-854 1e-16 56.5 In-house 40-138 (144) alignment 
Range on Protein: 750-854
Range on HMM: 40-138/144.0
NNRTKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHgMEDPLVVHCSGGIDRSGIFVAMETALtkieiVEAFNPLEIVRMMRDQRGMMLPALNQ
   . .|...|....|.|   .||   ...|.|.. .....   . | .||||.|..|.| .||.   .     .. ... |.....| .| .. |  .|
yepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgq

YKFFC
..| .
lrfLl
subfamily_hpo-7_pd Subfamily hpo-7 682-820 1.3e-16 55.3 In-house 46-180 (263) alignment 
Range on Protein: 682-820
Range on HMM: 46-180/263.0
TCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQ-GNSTEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDWSESNVPLVKADFL
|   |.|..  ..   .|||.|  |||..|| .|.| .  .   .   .. .    .| |  |....   .. |. . . | ..  | | | |    . |
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

RFIRRLHTLRhgmedPLVVHCSGGIDRSGIFVAMETALTK
. ..    ..     .|||||| || ||  |. .|..  |
nilkvarnsk.....slvvhcstGiGrsaafsvaElvyqk
PDZ PDZ domain (Also known as DHR or GLGF) 476-548 4.3e-16 49.0 Pfam-A 2-73 (81) alignment 
Range on Protein: 476-548
Range on HMM: 2-73/81.0
IRLNPDSEGRFGFHVKGGLDLN-LPVFVSKVKEDsPASQCQPpLEEGDQVLFVNGMSTDTATHIEVITAIKSSL
..|.....|..|| .||| | .  ..|||.| .. .| .... |.|||..| ||| .. . .| |.. |||.. 
vslekekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 623-854 7.7e-16 52.6 In-house 43-272 (303) alignment 
Range on Protein: 623-854
Range on HMM: 43-272/303.0
KLPQNLSKNRYRDITAYDITRVHLLDGpvDYINANYVNMDipstcQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGNS
.. .|. |||. |.   | ..|.| |    || |.|...|        . |.|| |.. |. |||||. ||    ...|    |  |.     .| . . 
qfvknmdknrfvdvicldhskvklsds..syihasyleld.....sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf

TEYGPFQIYCESDRKDNLCCTRHFVLKNNRTKEEKPIIHLQ-FLDWSESNVPLV-KADFLRFIRRLHT-LRH-GMEDPLVVHCSGGIDRSGIFVAMETAL
 ..    |     .. .|     . .      . | ..|.. . .|  ...|    . |.. | .| . ||.     | |     |  |.| |  .||| 
lkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

TKIEIV-EAFNPLEIVRMMRDQRGMMLPALNQYKFFC
  .     ... .  . ..|. |   .  | |. .  
lslhseqasldlvkclenvrngrlhavqnlsqfsvvy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 650-722 3.1e-12 40.5 In-house 89-159 (349) alignment 
Range on Protein: 650-722
Range on HMM: 89-159/349.0
PVDYINANYVNMDIPSTCQvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVKCCRYWPDQGNS
. |||||||...   |. .  .|| || |.  |  ||....  .|   .. |.|  |..  || .|| .   |
lddyinanylkltrisvek..kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsys
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 602-720 5.3e-12 39.9 In-house 72-182 (244) alignment 
Range on Protein: 602-720
Range on HMM: 72-182/244.0
SVLVSFDRLYRKKPGMLTIASKlPQNLSKNRYRDITAYDITRVHLLDGPV--DYINANYVNMdipsTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIV
. . . . . |  | ..  | . |.|  |||      .|. || |  | .   |||| .|        .   ||.|| |. .| .|||.|. |.    .|
nyiqgsqniirpdpsvmkdafn.pnnswknregaglpfdfnrvplskgsmgntyinasfvgc....lgrtaeyiltqhpladtsmdfwkmmlerhvnvlv

MLTDIMEEGKvkccrYWPDQG
.|  . || .     ||||  
vlgsveeede.....ywpdse
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 620-850 2.4e-11 37.6 In-house 30-277 (302) alignment 
Range on Protein: 620-850
Range on HMM: 30-277/302.0
IASKLPQNLSKNRYRDITAYDITRVHLLDGPVDYINANYVNMDipstcqVVRYIVTQGPM-----------------QNTCIDFWQMVWEQGCGFIVMLT
 ...| ...|. | .    .  |  .| | . |.|||| ...|       ...|..||||                 ..|.  .| .. .   . .| |.
tstnlekdiserrkslficepktmaklvdfkndfinanvlkld......eikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlc

DIMEEGKVKCCRYWPDQ-GNSTEYGPFQIYCESDR--KDNLCCTRHFVL-----KNNR--TKEEKPIIHLQFLDWSESNVPLVKADFLRFIRRLHTLRHG
...|... ||  |. |. |.  ..| . .   | .   ...   ..|.|     ||..  .| .|..  |.|  | .   |      |  ..   . .. 
sfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn

medpLVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQY
    ..|||| |. |.| .||.   .      .  . |.||  .|. |   .   .| 
....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 793-858 1.1e-09 32.6 In-house 227-292 (297) alignment 
Range on Protein: 793-858
Range on HMM: 227-292/297.0
MEDPLVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIV
 . .|.|||| |. |||. |  .. |.|.      .   |....|.|| ... .|.|...  | ..
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
FA FERM adjacent (FA) 306-337 8.3e-09 24.2 Pfam-A 15-46 (47) alignment 
Range on Protein: 306-337
Range on HMM: 15-46/47.0
KTEKQVVEASKSIARDGQRIRRTPSKRYPKRS
.|||||.|.|. | |  ... |.|||||..|.
RTekQvieesreigrkppsfeRspskrylsrr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 672-749 1e-08 28.9 In-house 238-312 (440) alignment 
Range on Protein: 672-749
Range on HMM: 238-312/440.0
YIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEgkvKCCRYWPDQGNSTEYGPFQIYCESDRKDNLCCTRHFVLK
.| || |.. | .|||..| .     |.|| .. .     |  ||| .  |  .||| .      . |    | . ||
fiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 798-861 1.7e-08 28.7 In-house 1-64 (69) alignment 
Range on Protein: 798-861
Range on HMM: 1-64/69.0
VVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAY
||||| |  |.| |.|.   ...|      . .. |. ||  | ||.   |.| |  | .|.| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 797-860 1.8e-08 28.7 In-house 1-64 (69) alignment 
Range on Protein: 797-860
Range on HMM: 1-64/69.0
LVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQA
.||||| |  |.| |.|.   ...|      . .. |. ||  | ||.   ..| |  | .|.|
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 761-860 2.1e-08 28.0 In-house 93-193 (440) alignment 
Range on Protein: 761-860
Range on HMM: 93-193/440.0
HLQFLDWSESNVPLVKADFLRFIRRLHTLR-HGMEDPLVVHCSGGIDRSGIFVAMETALTKIEIVEAFNPLEIVRMMRDQRGMMLPALNQYKFFCDCIVQ
. ..  | .  || . .  |..|. .   . .  . ||.|||| |  |.|. .|... | . .  .  . . ..  ||..|  |. . .|| |  .....
qyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavle

A
.
g
FERM_C FERM C-terminal PH-like domain 246-284 8.3e-08 22.7 Pfam-A 46-85 (90) alignment 
Range on Protein: 246-284
Range on HMM: 46-85/90.0
SISLGE-MDERVVGFHMDNHEASKRLWVACIEHHAFFRMS
.| | .  ...|. |........| |.  |||.|..||  
tiklrdekkkdvlkFyssqlrvnklllklcienhdlfrrr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 610-699 1.6e-07 25.2 In-house 21-114 (347) alignment 
Range on Protein: 610-699
Range on HMM: 21-114/347.0
LYRKKPGMLTIaSKLPQNLSKNRYRDITAYDITRVHLL---------DGPVDYINANYVNMDIPSTcqvvRYIVTQGPMQNTCIDFWQMVWEQGCGFIV
|    |  .|  ..  ..||||| .|    | ||| |          | .  |||| ....|  |.     ||.|| |. .|  |||.||       .|
lanyspskfts.vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnask....eyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_CG42327_pd Subfamily CG42327 794-854 1.8e-07 25.1 In-house 247-308 (319) alignment 
Range on Protein: 794-854
Range on HMM: 247-308/319.0
EDPLVVHCSGGIDRSGIFVAMETALTKIEIV-EAFNPLEIVRMMRDQRGMMLPALNQYKFFC
  ||||||| |. |.|. .| . |. ..|   .. .  ..|  .| .|.  . . .||.|  
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiy
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 639-723 1.9e-07 25.4 In-house 5-76 (130) alignment 
Range on Protein: 639-723
Range on HMM: 5-76/130.0
YDITRVHlldgPVDYINANYVNMdipsTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKvkccrYWPDQGNST
....|..      .||||..| .    . .   |. || |. .|..|||.|. |.    .|.|  . || .     ||||     
fevsrlq....gntyinasfvGl....lgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 792-857 3.8e-06 20.9 In-house 260-340 (350) alignment 
Range on Protein: 792-857
Range on HMM: 260-340/350.0
GMEDPLVVHCSGGIDRSGIFVAMETALTKIEIVEA--------------FNPLE-IVRMMRDQRGMMLPALNQYKFFCDCI
   .|..|||| |. | |..|...  | ..||.|               ..... ||  .| ||  |   |.|. |  ...
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeal
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 623-711 5e-06 20.2 In-house 30-117 (332) alignment 
Range on Protein: 623-711
Range on HMM: 30-117/332.0
KLPQNLSKNRYRDITAYDITRVHLL--DGPVDYINANYVNmdipSTCQVVRYIVTQGPMQN-TCIDFWQMVWEQGCGFIVMLTDIMEEGKVK
|. .|.  ||   . ..| .|| |   ||  |. ||..|.       .   ||..| |... |   ||.|| |.   .|... || |. | |
kflnnmdmnriphlycfdhsrvelapqdgkddfynaswvd....gyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk