Gene PTPN6-6 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP057_AA protein Get Run
AqueP057_AA_218-510 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 209-517 6.5e-151 496.6 In-house 2-305 (306) alignment 
Range on Protein: 209-517
Range on HMM: 2-305/306.0
TSFMAKSIKDRVSELEKeTGDIMGKAGFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHggDPSIVGSDYINANYISGEVPGSEK
||..||.|..||||||| ... ..||||.||||.|||.|...|.||||||..|||.|||||||||||||||.|.  .||..||||||||||..||.||.|
tsllakeieqrvselek.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdk

HYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPD
.||||||||.||..|||.|.|||.|..|||||.|||||..|||||||  .|. |||.|||.| .|  . .||.||. ...... ...||||.||||.|||
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPd

HGVPQDPGTVLSFLQDINSKQDELVTTgnEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYH
||||.|||.||.||.|.|.||.|| ..  |.||..||||||||||||||||||||......|..||.|||.....||.||||.|||||||||||..| ..
hgvpkdpgavLdfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

IETQRQLSE
|||...|.|
ietkkklee
0050432 (Phosphotyrosine protein) phosphatases II 205-511 6.3e-101 333.0 In-house 13-301 (308) alignment 
Range on Protein: 205-511
Range on HMM: 13-301/308.0
PFNATSFMAKSIKDRVSELEKETGDIMGKAGFWEEFEQLQQQECrhLFSRKEGARVENKTKNRYKNILPFDHTRVVLhggD-PsivgSDYINANYISGEV
.|  ||....|.| .| .| |   . ... ...||||.|... .  |.... ....|||.|||||.|||.||.||.|   | .    ||||||.|..| .
lfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl...deg....sdYInAsyvdgys

PGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGI--NETGEYGDISVQNATECINPHYIYREFIIHRIEDPsNQREVFHY
 ......|||||.||.|..|||.|.|.. ...||| |..||.||.|||.|||    ... |||...| .  | ....|..|....  ..|. . |.| |.
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthf

HFKAWPDHGVPQDPGTVLSFLQDINSKQdelvttgnEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFV
|...|||||||..|  .|.||. .....        ..|| .||||||.|||||||..|.||. . ..     ||.. |.. .| || |||||..||.|.
hytnWpdhgvPpspeilldflelvrksl........pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylfl

YRSILYHIET
|| .|.....
yralleylkl
0046845 (Phosphotyrosine protein) phosphatases II 235-512 1.1e-99 328.7 In-house 1-277 (284) alignment 
Range on Protein: 235-512
Range on HMM: 1-277/284.0
GFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSIVGSDYINANYISGEVP---GSEKHYIATQGCLPTTINDFWKMIWQE
|..||||.|... . .|.|.. ....||..|||||.|||.||.||.|.  |... .||||||.|..|       ..|..||||| ||.|..|||.|.|..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

SSQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDE
 ...||| |..||.||.|||.||| ..|. .|||..| .  | ....|..|.. . ... ... |.| |.|...|||||||..|  .|.||..... ...
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

lvttGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQ
     . .|| .||||||.|||||||..|.||. . ..|  . ||.. |.. .| || |||||..||.|||. .|... . 
....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_PTPRD_pd Subfamily PTPRD 232-514 3.2e-99 328.1 In-house 21-286 (564) alignment 
Range on Protein: 232-514
Range on HMM: 21-286/564.0
GKAGFWEEFEQLQQQecrHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQE
... | ||.......   . |. .. .  .|| ||||.||...||.||||.  .    |||||||..| |    ..|.|||||| |..||.|||.|.|..
sdlkfeeeykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweq

SSQIIVMTTNEVERGRNKCARYWPGINeTGEYGDISVQNATECINPHYIYREFIIhRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdE
 |..||| |. .|.|..||..|||  . | .||.. |.   |    .|. |.|.. . .. |..||| ..|| .|||||||. . ..|........ . |
nsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e

lvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQ
     .. ||..||||||.||||||||||..|. . .   |..|||   ....|.||  |||||.|| |... ||  .. . .
.....pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
0045450 (Phosphotyrosine protein) phosphatases II 232-509 2.5e-96 318.3 In-house 25-304 (307) alignment 
Range on Protein: 232-509
Range on HMM: 25-304/307.0
GKAGFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSIVGSDYINANYISG------EVPGSEKHYIATQGCLPTTINDFW
...|...|||.|.......|.........|||.|||||.|||.|||||.|.  |.|. .||||||.|.        ... . ...|||||.|| |..|||
fltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

KMIWQESSQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDI
.|.|.. ...||| |..||.||.|||.|||  .|. .||.. | .  | . ..|..| . ... .  .. |.| |.|...|||||||... ..|.|.. .
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

NSKQDELvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
.. ..||    ...|| .||||||.|||||||.....|  . ..|   |||.. |..|.|.||.|.||...||.|.|. .|...
rkaleel....pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0036941 (Phosphotyrosine protein) phosphatases II 223-514 2.9e-95 314.2 In-house 2-282 (297) alignment 
Range on Protein: 223-514
Range on HMM: 2-282/297.0
LEKETGDIMGKAGFWEEFEQLqqQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLhgGDpsiVGSDYINANYIsgEVPGSEKHYIATQGCLPTTIN
|.|   .....|....|||.|  ... .|.|.. ....||..|||||.|||.|||||.|  .|    |||||||.|.  .... ....|||||.||.|..
llkllekllflalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVkl..dd...egsdYinAsyv..dgydlkrkfIatqgPlpntve

DFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGI-NETGEYGDISVQNATECI--NPHYIYREFIIHRIEDPsNQREVFHYHFKAWPDHGVPQDPGTVL
|||.|.|.. ...||| |..||.||.|||.|||   .|. .|||..|.. .. .  ...|..|.. .  .... ..|.| |.|.. |||||||..| ..|
dFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespasll

SFLQDINSKQDELvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQ
.|.. .......|    ...|| .||||||.||.||||..|..|. . ..  |  |||  |.. .| || |.|||..||.|.|. .|... ....
dfielvrkvlkll....psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0040438 (Phosphotyrosine protein) phosphatases II 231-512 3.5e-95 314.2 In-house 15-279 (317) alignment 
Range on Protein: 231-512
Range on HMM: 15-279/317.0
MGKAGFWEEFEQLQQQecrHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsIVGSDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQ
... ...||||.|...   .| ........||| ||||..|||.||.||.|.  .. . .||||||.|.  ..|   ...|||||.|| |..|||.|.|.
sdftalleefedllsl...kldtysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyv..dgpnlkrkfIatqgPlpntvedFwrmvwe

ESSQIIVMTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHRIeDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQD
. ...||| |...|.||.|||.|||  .|| .|||..|..  |  ......|.. .    . |..|.| |.|...|||||||..| ..|.||. ......
qgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale

elvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQ
      ...||..||||||.|||||||.....|. . . |   .||.. |.. .|.||.|.|||..||.|.|. .|... . 
......dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0051299 (Phosphotyrosine protein) phosphatases II 232-509 3.9e-95 313.9 In-house 21-286 (288) alignment 
Range on Protein: 232-509
Range on HMM: 21-286/288.0
GKAGFWEEFEQLQQQECRhlFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsIVGSDYINANYISGevPGSEKHYIATQGCLPTTINDFWKMIWQE
|..|..||||.|... .   .... ....||..||||..|||.||.||.|.  |. . |||||||.||.|  . .....|||||.||.|..|||.|.|..
gltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidg..ynlkrkfIatqgPlpntvedFWrmvweq

SSQIIVMTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHRIE---DPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSK
 ...||| |..||.||.|||.|||  ... .||||.| .  | ....|..|.... ...    ... |.| |.|...|||||||..|  .|.||......
nvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrka

QDelvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
.       . .|| .||||||.|||||||..|.||. . ..     ||. .|.. .| || |||||..||.|||. .|...
la......sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 219-511 3.6e-92 304.2 In-house 17-291 (297) alignment 
Range on Protein: 219-511
Range on HMM: 17-291/297.0
RVSELEKETGDIMGKAGFWEEFEQLQQQECrhlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSIVGSDYINANYIsgEVPGS-EKHYIATQGCL
.| .| .   . ..| ....|||.|... .    ........|||.|||||.|||.||.||.|.. | .  .||||||.|.  ...    ...|||||.|
svldlllllekansktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPl

PTTINDFWKMIWQESSQIIVMTTNEVERGRnKCARYWPgiNETGEYGDISVQNATECINPHYIYREFIIHRiEDPSnqREVFHYHFKAWPDHGVPQDPGT
| |..|||.|.|.. ...||| |..||.|| |||.|||  .|.|.|||..| . ..  ...|..|.. . . ...|  |.| |...  |||||||... .
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywp..eeggtygdftvtllkvehldgytvrtlevtn.nges..rtvthfqytgwpdhgvppslel

VLSFLQDINSKQDELvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
.|.||. ... . ||    ...|| .||||||.|||||||.....|. .       .||.. |.. .| ||.|.|||..||.|.|. .|... .
lleflelvrealael....pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkr
0047943 (Phosphotyrosine protein) phosphatases II 228-509 1.2e-90 299.0 In-house 6-272 (273) alignment 
Range on Protein: 228-509
Range on HMM: 6-272/273.0
GDIMGKAGFWEEFEQLqqQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLhggdpSIVGSDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKM
 .  |.....||||.|  ... .|.... ....|||.|||||.|||.||.||.|     .  |||||||.|.  ... .....||||| || |..|||.|
ekllgltllleefell..lslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyv..dgynlkrkfiatqgPlpntvedfwrm

IWQESSQIIVMTTNEVERGRNKCARYWPGINE--TGEYGDISVQNATECINPHYIYREFIIHRIEDPSnQREVFHYHFKAWPDHGVPQDPGTVLSFLQDI
.|.. ...||| |..||.||.|||.|||  ..  . .||...| .  | ....|. |.... .....   |.| |.|.. |||||||...  .|.|....
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielv

NSKQDELVTTgnepGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
.... .|.      || .||||||.|||||||..|.||. .   |    ||.  |..|.| || |||||..||.|.|. .|...
rkalealpsn....gpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrflyealleyl
DSPc_SM00195 236-509 2.3e-89 294.6 In-house 2-262 (263) alignment 
Range on Protein: 236-509
Range on HMM: 2-262/263.0
FWEEFEQLQQQECRHlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQI
..||||.|....  .  . .|... .||.|||||||||.||||| |.  . .  ||||||||||.|.   ..|.||||||.||.|..|||.|.|.| ..|
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvki

IVMTTNEVERGRNKCARYWPGI-NETGEYGDISVQNATECINP-HYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELv
|||.|.|.|.|..||.||||   ... ..|.|||..  . . . ..| |.. .   .. ...|.| .|..|.|||||||...  ||..|. .......  
ivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.

ttgnePGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
      ||..||||||.||||||..|||.|. . ..     |||.  .. .| || |||||..||.|.|. ||. |
.....sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 236-509 2.3e-89 294.6 In-house 2-262 (263) alignment 
Range on Protein: 236-509
Range on HMM: 2-262/263.0
FWEEFEQLQQQECRHlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQI
..||||.|....  .  . .|... .||.|||||||||.||||| |.  . .  ||||||||||.|.   ..|.||||||.||.|..|||.|.|.| ..|
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvki

IVMTTNEVERGRNKCARYWPGI-NETGEYGDISVQNATECINP-HYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELv
|||.|.|.|.|..||.||||   ... ..|.|||..  . . . ..| |.. .   .. ...|.| .|..|.|||||||...  ||..|. .......  
ivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.

ttgnePGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
      ||..||||||.||||||..|||.|. . ..     |||.  .. .| || |||||..||.|.|. ||. |
.....sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 232-509 2.6e-89 294.7 In-house 18-277 (278) alignment 
Range on Protein: 232-509
Range on HMM: 18-277/278.0
GKAGFWEEFEQLQQQECrhlFSRKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQE
.|.....|||.|...     .... ....|||.|||||.|||.||.||.|.  ...  .||||||.|.  ...   ...|||||.|| |..|||.|.|..
lktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsl.lggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwel

SSQIIVMTTNEVERGRNKCARYWPgiNETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNqREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDe
 ...||| |..||.||.|||.|||  ... .|||..| .  |  ...|. | . ...  |.   |.| |||...||||||| .. ..|.||........ 
gvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale.

lvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
     ...||..||||||.|||||||....||. ..  |    ||.. |.. .| || |.|||..||.|.|. .|...
.....dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 213-514 1.8e-88 291.7 In-house 4-285 (318) alignment 
Range on Protein: 213-514
Range on HMM: 4-285/318.0
AKSIKDRVSELEKetgdiMGKAGFWEEFEQLQQQEcRHLFSRKEgARVENKTKNRYKNILPFDHTRVVLHGGdPSIVGSDYINANYISGEVpgSEKHYIA
.. ....| .|..      |.  . ||.|.|...| ..  | |      ||.|||| |||..||||| |.    . .|||||||||| |    ..| |||
vedleshvrrlre.....sGelllseeyerlsrse.etvtslks.lepvnkaknryanilaydhtrvkLqml.egeegsDyinanyidGyr..rkkayia

TQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHRiEDPSNQREVFHYHFKAWPDHGVP
.|. || ||.|||.|.|.  |..||| |.|.|||..|..||||. ... .||.. |.   |    .|. ||| ..| .. ...|.|  ||. .|||.|||
aqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs.kgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvp

QDPGTVLSFLQDINSKQDElvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQ
......|........ | .     .. ||..||||||.||||.||..||||. . .   || ||.   .. .| ||  |||||.||.|.|  .|  ... 
esgaslldlvrqvskaqqk.....sgagpivvhCsaGvGrtGvfiavdillerika...ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg

RQ
 .
dt
subfamily_PTPRB_pd Subfamily PTPRB 233-513 7.4e-88 289.4 In-house 24-289 (293) alignment 
Range on Protein: 233-513
Range on HMM: 24-289/293.0
KAGFWEEFEQLQQQECRHlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQES
...| ||.|.|.. .  .  . |   . .|..||||.||||.||.|| |.  . .  ||||||||||.|    |....||||| ||.|..|||.|.|.. 
dlrfseeyeelkavgkdq..avkaaelavnraknrytnilpydhsrvkLaalk.desgsDYinanyipgyn..sprefiatqGPlpetvddfWrmvwekk

SQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIHRiedPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDEl
|.|||| |. ||.|. || .|||  .|.  ||||.|.  .|    ... ||. |..    ...|.| .|||..|||||||... |.|.|.. ....... 
ssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek.

vttGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
    .. .|..||||||.||||||| .| ||. . .   |  |||   .. .| .|  .||||.|| |.....|  .....
...taskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_PTPN12_pd Subfamily PTPN12 232-514 1.7e-82 271.6 In-house 6-282 (290) alignment 
Range on Protein: 232-514
Range on HMM: 6-282/290.0
GKAGFWEEFEQLQQQECR----HLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSIvGSDYINANYISGevPGSEKHYIATQGCLPTTINDFWKM
|.. | .||..|.... .    . .|...| . ||..|||||.|||.|..||.|.  . .  ||||||||.| |  . ....|||.|| ||.|..|||.|
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee.gsdYinanfikg..vegkleyiaaqgPLpktlddfWrm

IWQESSQIIVMTTNEVERGRNKCARYWPGINETGE-YGDISVQNATE-CINPHYIYREFIIHRIedpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDI
||. . .|.||  .||| |..||.||||  .|.   .|...|.. .|  ..  .. | . ...    ...|.|  .|..||||||||. . ..|......
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielv

NSKQDelvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQ
.. |.      .|  ||.||||||.||||| |.||.  ... ..  . ..|.   .. .| ||. .|||..||..||....  .... .
relqe......sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
Y_phosphatase Protein-tyrosine phosphatase 262-506 4.2e-82 270.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 262-506
Range on HMM: 1-234/235.0
NKTKNRYKNILPFDHTRVVLhggDPSIVGSDYINANYISGEVpGsEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWP-GINET
||.|||||.|||.|.||| |   . |   ||||||||..|     .|..|||||.|. ||.|||.|.||| ...||| |...|.||.|||.|||   .|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

GEYGDISVQNA-TEC-INPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvttGNEPGPLIVHCSAGIGRTGTFIV
 .||||.|..   |. .. .|. |.. ..  ...|..||| ..|...|||||||..|  .|..........       .. ||..||||||.||||||..
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfva

IDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
.||||. . ...    ||.  ... .|.|| ||||...||.|.|. ||
ldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 262-506 4.2e-82 270.5 In-house 1-234 (235) alignment 
Range on Protein: 262-506
Range on HMM: 1-234/235.0
NKTKNRYKNILPFDHTRVVLhggDPSIVGSDYINANYISGEVpGsEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWP-GINET
||.|||||.|||.|.||| |   . |   ||||||||..|     .|..|||||.|. ||.|||.|.||| ...||| |...|.||.|||.|||   .|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

GEYGDISVQNA-TEC-INPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvttGNEPGPLIVHCSAGIGRTGTFIV
 .||||.|..   |. .. .|. |.. ..  ...|..||| ..|...|||||||..|  .|..........       .. ||..||||||.||||||..
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfva

IDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
.||||. . ...    ||.  ... .|.|| ||||...||.|.|. ||
ldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
0045098 (Phosphotyrosine protein) phosphatases II 253-510 4.6e-82 270.8 In-house 24-273 (278) alignment 
Range on Protein: 253-510
Range on HMM: 24-273/278.0
SRKEGARVENKTKNRYKNILPFDHTRVVlhggdpsivgsDYINANYISGEvpGseKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCAR
.  .. ...|. |||||.|||.||.||.           |||||.||.|   .  |..|||||.||.|..|||.|.|.. ...||| |..||.||.|||.
eitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy..p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPGiNETGEYGDISVQNATECINPHYIYREFIIHRI---EDPSNQREVFHYHFKAWPDHGVPQDP--GTVLSFLQDINSKQDELVTTG-------NEPG
|||  ... .|||..| .  |.....|..| .... .   .    .|.|.|.|.. ||||||| .|    .|..|. |.. ...|..         ...|
ywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PLIVHCSAGIGRTGTFIVIDILLNVMmqqgfEADVDIQRAIQLVRAQRSG-MVQTEQQYKFVYRSILYHIE
| .||||||.|||||.......|  .     |  ||.. |.. .| || | .||...||.|.|. .|....
pvlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0040439 (Phosphotyrosine protein) phosphatases II 254-509 2e-81 268.5 In-house 3-246 (249) alignment 
Range on Protein: 254-509
Range on HMM: 3-246/249.0
RKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARY
.... ..||| ||||..|||.||.||.|.   |.  .||||||.||  ... . ...|||||.|| |..|||.|.|.. ...||| |..||.||.|||.|
ysvallpenkdknrypdilpydhsrvklsi.lpglflsdyinAsyi..dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPGiNETGEYGDISVQNATECINPHYIYREFIIHRIeDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELvttgNEPGPLIVHCSAGIGRT
||  ... ||||..|..  . ....|. |.. ....   .. |.| |...  |||||||... ..|.|.. ... ..||    ...||..||||||.|||
wpl.ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel....pkggpvlVHCsaGvgRt

GTFIVIDILLNVMMqqgFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
||||.....|. .     | .||.. |..|.| ||.|.||...||.|.|. .|...
Gtfiaaylmleqle...kelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 211-511 2.7e-81 268.1 In-house 5-285 (319) alignment 
Range on Protein: 211-511
Range on HMM: 5-285/319.0
FMAKSIKDRVSELEKetgdiMGKAGFWEEFEQLQQQECRhlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsIVGSDYINANYISGEvpGSEKHY
.  . .|.|. .|..      |. .. .||..|.. .     . ..  . |||.||||.|||..|.|||||   |  . |||||||..| |     .. .
ievqeLkerlkalas.....tgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgy..qerekf

IATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINeTGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHG
||||. | .||.|||.|.|.| | |.|| |. ||... |. .|||  |   ||| . |.   |    .|| |.. ...  .  . |||.|.....||||.
iatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen.feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhd

VPQDPGTVLSFLQDINSKQDelvttGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
||..  ..| .|..|.  ..     ... ||..||||||.||||||||.|. |. . .   |. .|.   .. .|.||  |||...||||.|  .|  .|
vPekatslldllkrirksre.....ktqsgPivvhCsaGvGRtGtfivldamlervke...egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

T
.
a
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 229-510 3.2e-81 267.5 In-house 16-280 (288) alignment 
Range on Protein: 229-510
Range on HMM: 16-280/288.0
DIMGKAGFWEEFEQLQQQEcrHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMI
. ....|| ||...| . |  .  | . | . .|..||||.||||.|..|| |....    |.|||||.|| ||  ...|.|||||| |. |.||||...
sarnrtgfseeynsLaale..ktksvtagrlavnakknRyrnilpyDekrvklkkle.eeagaDYinasyidge..kkkkkyiatqgPladtvndfWelv

WQESSQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIHrieDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSK
... .. ||| |. ||.|..|| .|||  ..  .||.. |.   .    ... |.....      ...|. .|...||||||||..   .| .|. ..  
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkva

QDELvttgnePGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
...        ||.|||||||.|||||||..| |.. . .   |  .|.  ... .| ||  .|||..|| |.|. .|  ||
nqad......tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllslie
0042113 (Phosphotyrosine protein) phosphatases II 257-509 7.8e-80 263.1 In-house 4-243 (245) alignment 
Range on Protein: 257-509
Range on HMM: 4-243/245.0
GARVENKTKNRYKNILPFDHTRVVLHgGDPSIVGSDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG
....|||.||||..|||.|||||.|   |..  .||||||.|.   ..   ...||||| || |..|||.|.|.. ...||| |.|.|.||.|||.||| 
allpenkdknrysdilpydhtrvkls.pdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

iNETGEYGDISVQNATECINPHYIYREFIIHRiEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvttgNEPGPLIVHCSAGIGRTGTF
 .|. .|||..|.. .| ....|. |.. ... .  . .|||.|||.  ||||||| .. ..|.||. ... . |     ...||..||||||.||||||
.gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtf

IVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
|.....|. .   .   .|... |.. .| ||.|.|||..||.|.|. .|...
iaaylmleqlekel...gvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 258-508 5.3e-79 260.4 In-house 6-241 (243) alignment 
Range on Protein: 258-508
Range on HMM: 6-241/243.0
ARVENKTKNRYKNILPFDHTRVVLhggDPsivgSDYINANYISGEvpgseKHYIATQGCLPTTIND----FWKMIWQESSQIIVMTTNEVERGRNKCARY
 ..||..||||..|||.||.||.|   ..    |||||||.| .      ...||||| || |..|    ||.|.|.. ...||| |..||.||.|||.|
llpenlsknrysdilpydhsrvkl...eg....sdyinanliyvt.....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPgiNETgEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELVT--TGNEPGPLIVHCSAGIG
||  .|. .|||..|..  |   ..|..|.. . ... .  .|.|.|||. .|||||||..|  .|.||..... ..||..  . .. ||..||||||.|
wp..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTFIVIDILLNVMmqqgfeaDVDIQRAIQLVRAQRSG-MVQTEQQYKFVYRSILYH
||||.|.....|  .       .||.. |..|.|.||.| .|||..||.|.|. .|..
RtGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRG_pd Subfamily PTPRG 224-514 5.8e-79 260.8 In-house 7-292 (563) alignment 
Range on Protein: 224-514
Range on HMM: 7-292/563.0
EKETGDIM--GKAGFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGdPSIVGS-DYINANYISGEVpgSEKHYIATQGCLPTT
.|   ..   |. || ||||.||..   . .  .   . ||| |||| ||...|..|| |..  | . .. |||||||| |     .| .||||| |..|
akhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklspl.pgkkkklDYinAnyidGyq..kskafiatqgplkdt

INDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHR--IE---DPSNQREVFHYHFKAWPDHGVPQDP
..|||.|||.. ..|||| || |||||.|| .|||  .|. .|| ..|.  .| .   |  |...|.   ..   .  ....| .||.  |||||||. .
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs

GTVLSFLQDInskqdeLVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQ
  ||.| .          .. .| ||..||||||.|||||.||.| ||. . |   |  |.. . .. .||||  .|||| || |..  .|  | .. .
lpvLifvkks......saankaeaGPivvHcsaGvgrtGtyivldtllkqiqq...enavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 233-512 1e-77 256.1 In-house 14-279 (281) alignment 
Range on Protein: 233-512
Range on HMM: 14-279/281.0
KAGFWEEFEQLQQQECRHlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQES
.||| ||.|.|.. . ..  . .   . ||..||||.||  .|.|||...  . .   .||||||...|    .||.|||||| .|.....||.|.|...
naGfieeyeklaaigvdn..tataskadenvlknrYsnivaYDatrvkvtpne.enkntDYinanfvpgy..kgekeyiatqgPvPaslvafWqmvweqk

SQIIVMTTNEVERGRNKCARYWPGINETGEYGDISVQNATECINPHYIYREFIIhrIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDEL
 ..||| |.|.| |. || ||||  |.. .|||. |.. .|  ...|| |.| .   .. ...||| . ...||||||||...  .|.| ..... ... 
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekk

VTtgnepGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQ
        ||..|||||.|||||.| .| |.. . ..  ....|..  .. .| .|  ||||  ||.|||. .|  .. .
tk.....aplvihCsaGvGrtGtyialDrlvkaveae..leeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPN9_pd Subfamily PTPN9 230-511 2.4e-77 254.9 In-house 12-292 (297) alignment 
Range on Protein: 230-511
Range on HMM: 12-292/297.0
IMGKAGFWEEFEQLQQQECRHLFSRKEgaRVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIW
 .|| |  .|........    | . .     | .||||...| .|.|||||   |     |||||||.. |     .| .||||| |. |..|||.|.|
ekgkrGlskeyaeirnepveGtflask..lranleknrytdvlcydetrvvlakvded.easdyinanfvdGyk..qkkafiatqGplkktvsdfWrmvW

QESSQIIVMTTNEVERGRNKCARYWP-GINETGEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSK
...  .|||||  ||||| ||..||| . ... |.||.||.|     . .|  | . |..... ...|.| |. | .|||.|||..  ..| .|. . .|
eqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrek

QDELVTT------GNEPG-PLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
|  .|..      |.  | |..|||||||||||||| .|| |. . .   .. ||.. ...|.|.||. ..||..||.| | ..| .  .
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee...vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_PTPN3_pd Subfamily PTPN3 254-507 6e-77 253.3 In-house 33-273 (280) alignment 
Range on Protein: 254-507
Range on HMM: 33-273/280.0
RKEGARVENKTKNRYKNILPFDHTRVVLHGGDpsivgSDYINANYISGEVPGSE--KHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCA
 ..  . || .||||..|||.|.||| |. ..     .|||||||.. |.|...  ..|||||| |..| .|||.|.|...|..||| |. ||||| || 
isaarkpenlsknryrdilpydatrvklkese.....tdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

RYWPGINETGEYGDISVQNATECINPHYIYREFIIHRIEdPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvttGNEPGPLIVHCSAGIG
.|||  ... |||..||.   |  .  |..||..... |  ...|....  . ||||||||.|.  .|.|.. .....        .  |..||||||||
qyWPetedeleygefsvkcekedetksyvlrelvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklr......sgkeePvvvhCsaGig

RTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILY
||| .|.... | .. .   . .| .   .. .| ||. .|||..|||||  .|| 
rtGvlilletalaliea...aepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 254-510 7.9e-77 253.0 In-house 20-269 (274) alignment 
Range on Protein: 254-510
Range on HMM: 20-269/274.0
RKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSIVGSDYINANYISGEvPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARY
..|     ..||||||.||| ...||.|.  ...   |.||||||| |   . .| |.|||| ||.|..|||.||.||..|.|||.|.  |. ..|||.|
qeeldvfgsqtknryktilPnensrvllesessededssyinanyikGy.deeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPGINET---GEYGDISVQNATECINPHYIYREFIIHRIEDpsnQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvtTGNEPGPLIVHCSAGI
.|  ...   ..|||.....     . .|  |.....  |.   .|.| || . .|||| .|.|. |.|...........|   . .. .| .|||||||
fPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesree...enaklapvvvhCsaGi

GRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
|||| || |.| .. . .   |  ||. . .  .| .| |||||..||....| .  . .
GrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN13_pd Subfamily PTPN13 237-510 6.8e-75 246.8 In-house 14-270 (273) alignment 
Range on Protein: 237-510
Range on HMM: 14-270/273.0
WEEFEQLQqqECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsivgsdYINANYISGEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQII
 |||..|.  | . | . ..| . |||.||||.|.||.|.||| | .  .      ||||..|  .|   | .|||.|| ||.|..|||.|.|. ....|
aeefkelr..elkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevi

VMTTNEVERGRNKCARYWPGINE--TGEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDelvt
.| |.|.|.|. || |||| ...  .  .. . |..        .  |.. .. .|  .. ||| | .| .|||||||. .  .| |.. ... |.    
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....

tgnEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
   . ||..|||||||||.||.|.||..|... ..    ..|..  .. .| || |.|||..|| |||..||. ..
...dagPivvhcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 231-510 7.7e-75 246.9 In-house 24-291 (298) alignment 
Range on Protein: 231-510
Range on HMM: 24-291/298.0
MGKAGFWEEFEQLQQQEC-RHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEVpGSEkHYIATQGCLPTTINDFWKMIW
.. .|. .||..|.. .   . .. . . . ||| |||| .|...|..||||.  | .   |||||| ....   |..  .||||. |..|..|||.|..
kkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked.adeesdYiNAsflhayk.grn.afiatqaPltetvedFWrmvt

QESSQIIVMTTNEVERGRNKCARYWPGInETGEYGDISVQNATECINPHYIYREFIIHRIEDPsNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQ
.| .. ||| || .| .. |. .|||   .. .||.|.|.   .     .| |...... .   ..||| . ||  |||.|||.   .|| .|.... .|
eedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasq

DElvtTGNEpgPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
 .   .||.  |.||.||||.||.||||.|| .|. . .   |  ||. .... .|..| |.||||.||.|.|  .|  ..
qq...agnk..pvivqCsaGvgRsGtfiaidsvlervkk...eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPRA_pd Subfamily PTPRA 234-512 1.6e-74 245.8 In-house 32-299 (330) alignment 
Range on Protein: 234-512
Range on HMM: 32-299/330.0
AGFWEEFEQLQQQECRHLFsrKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESS
  | |||. |   . .  .  .  .. ||| |||. ||||.|..||.|   .  .  |||||| .| |      ...||.|| .  |..|||.|||.  |
klfreefnalPagpiqatl..elaskeenkeknrvvnilPydfsrvilsvke.GveesdyinasfidGyk..ekdkfiaaqGPkeetvedfwrmiweqks

QIIVMTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHRIEDPS---NQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQD
. ||| |.  || ..|||.|||  . .  ||.| |.   | .  .|  |.|..... | .   ..| |  .||..||| ||| .|  .|..|. ......
ativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

ElvtTGNepgPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYH-IETQ
    ...   |..||||||.||||||||.| .|. .     |  ||. .... .|.||. ||||..||.|.|. .| . .  .
q...sag...pivvhcsaGvGrtGtfivldavlervka...erkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygd
subfamily_Ptp69D_pd Subfamily Ptp69D 233-510 1.1e-72 239.8 In-house 21-287 (307) alignment 
Range on Protein: 233-510
Range on HMM: 21-287/307.0
KAGFWEEFEQLQQQecRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGdPSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQES
. |. .|.|.|...      | | ... ||. ||||..| .||.|||.|.   .    ||||||..| |     .|..|| |. . .||.|||.||.. .
dfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkki.ngkedsdYinasfikgy..kekkkfiaaqdPveatigDfWRmiaeqe

SQIIVMTTNEVERGRNKCARYWPgINETGEYGDISVQNATECINPHYIYREFIIHRIEDP----SNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSK
...||| .|. |  |.|||.||| |... .|||| |. . |   ..|| ||. . ....      ..|.|  ||...|.|  ||. . ..| ... ... 
vtlivmlsnlteknrkkcakYWp.iedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

QDELvttgnePGPLIVHCSAGIGRTGTFIVIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
.          .|..|||||| ||.|.|. .|.||.   |.  |  |||   .. .| ||. .||  .||.|.||..| ...
ykln......rsPivvhCsaGvgrsgifvaldsllq...qlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPRK_pd Subfamily PTPRK 234-507 1.8e-71 235.5 In-house 22-275 (314) alignment 
Range on Protein: 234-507
Range on HMM: 22-275/314.0
AGFWEEFEQLQQQecrhlfsRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESS
 || ||.| | .             . ||..|||...||..|..||.|.  |     ||||||..| .      ...|.||| |. |..|||.....| .
ygfkeeyeslfeg.......wdaakkdenreknrsgdilaydrsrvflitidgd.pssdyinaalidsyk..rpaafivtqgPlqetvkdfWrlvydenc

QIIVMTTNEVERGRNKCARYWPgiNETGEYGDISVQNATECINPHYIYREFIIHRIEDP-SNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDEl
  ||| |. || || || .|||  ..|  |||| |.     ..  .. | | ..... . ...||| ...| .||||.||.   ..|.... ....|.| 
asivmltelvevgrvkClkyWP..edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.

vttgnEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILY
     | |...|||||| |||||||.|||.|... ..|    ||.  |.. .|.... ||.||.||||.|  || 
.....eaGrivvhCsaGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 258-513 1.5e-70 232.3 In-house 16-268 (270) alignment 
Range on Protein: 258-513
Range on HMM: 16-268/270.0
ARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGI
. . .|. |||..|||  .|||.|.  .     . ||||||. | . |..|.|||..| ||||...||.|||.| .. |||||. .|.||.||.||||  
eaargkklnRyadiLPsPatRvrleeleed.sataYinAnyvrG.fdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

NET---GEYGDISVQNATECINPHYIYREFiihRIEDPSNQREVFHYHFKAWPDHGVPQDPG------TVLSFLQDINSKQDELVTTGnepgPLIVHCSA
...    |.|.|.| . .|  .  || ..    |.|. ...|.. |.....|||||||....       .|. |...   ..||  ..    ||.|||||
pkekvkledgkikvlalseekeegyiltrl...rleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae....PllvHcsa

GIGRTGTFIVIDILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
|.|||||.|..|| .... ..     ||. . |. .| .|  .||. .||.|.|.... ..|.. 
GvgRtGtlialDiavrlLeet...kkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerra
subfamily_PTPN14_pd Subfamily PTPN14 231-511 1.9e-70 232.3 In-house 20-298 (300) alignment 
Range on Protein: 231-511
Range on HMM: 20-298/300.0
MGKAGFWEEFEQLQQQECRHLFSrkEGARVENKTKNRYKNILPFDHTRVVLHGGDPSivGSDYINANYISGEVPGSEKHYIATQGCLPTTINDFWKMIWQ
. ..  . |.|......   |.|   ..  ||. |||.|..||....|| |     .   ..||||  |.  | |.|..||..|| |..|..|||.|.|.
leegkvfteyeripkkredalls..taklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWe

ESSQIIVMTTNEVERGRNKCARYWPGI---NETGEYGDISVQNATECINPHYIYREFIIHRIEdPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINS
.  |.||| |.| | |..|. .|.|     ..| |.|   |..      . .| . . .. .   ...|.|.|  .. |||||||.|. . ||.|....|
qgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

KQ---DELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
 .   .. | . ..  |..||||||.||||  |. |.|.. . .   . ..||..... .| ||  .|||  ||||||. .. ... 
vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 258-515 8e-70 229.9 In-house 5-248 (250) alignment 
Range on Protein: 258-515
Range on HMM: 5-248/250.0
ARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEVpGSeKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNkCARYWPgI
 . .|| |||| .|...|..||||.  . .   |||||| .. |   .. | .||||| |..||.|||.|...| |. ||| || .| ... . .||| .
kkpqnkeknryadiialdssrvvLekek.gdkesdyinasflhgyd.er.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.v

NETGEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvtTgnEPGPLIVHCSAGIGRTGTFI
... .|||. |.   . .   |. |.... . .  ...| | ..|| .||| |||.   .|| .|......|..   .  . .|.||.||||.||.|.||
ekaekyGdvtvsllskeefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqq...a..gnaPvivqCsaGvgrsGafi

VIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQL
.|| .|.   .   |  ||. . |. .|..| ..|....|| |||. ||  ...  ..
aidavle...rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedy
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 233-513 2.3e-69 228.9 In-house 21-287 (305) alignment 
Range on Protein: 233-513
Range on HMM: 21-287/305.0
KAGFWEEFEQLQQQECRHLFSRKEgarvENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQES
. |. .....|...|      .||    .||.|||.|.| ..|. |. |   ..|   ||||||.|. |    ..|.||..|| |..|..|||..|..| 
dkgleaqykslyeeeesidvgkke....ankaknrlkeitlldddriilte.keslddsdyinasyvdgy..krkkkyivaqgPlkntvadfWrliveek

SQIIVMTTNEVERGRNKCARYWPGINET-GEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDE
 . ||| |. || |..|| .|||.      |.|..||.   |   . || |.. |   .. ...| | .|..  |||||||| ....||...... .| .
vstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

lvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
     ..  ||.||||||.||||.||..|| |. . .   |  ||. . .. .| .| .|||| .|| |..  .   |..  
.....dkgvpllVhCsagvgRtGvfiavdialerlkk...EevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_PTPN23_pd Subfamily PTPN23 228-511 7.4e-69 226.7 In-house 9-282 (288) alignment 
Range on Protein: 228-511
Range on HMM: 9-282/288.0
GDIMGKAGFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHggdpsIVGSDYINANYISGEVPGSEkHYIATQGCLPTTINDFWKM
. . ||... ..|..|.|.. ..  .|   .   . .|||...|||.||.||.|.         ||||| .. . .||.  ..||||. |..|.||||.|
kmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlm

IWQESSQIIVMTTNEVERGRNKCARYWPG-INETGEYGDISVQNATECINPHYIYREFIIHrIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDIN
.... |..||| ... |.|..|..||||   .|| ..||.||    .   .... |..... ..|... ..| | ....||..|||. |.|.| ||. ..
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkle.tldadavksvshlqltsWpelGvPasPetllqfldeve

SKQDELVTTGNEpgPLIVHCSAGIGRTGTFIVID-ILLNVMMQQGFEadvDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
|. ..     .   ||.||||||.||||.| ..  .. ..  ..|     || . .. .|.||  |||...|.||.|  .| ... 
sayeavqrkskt..PlvvhCsaGvgRtgvfalvyaavrelekgngll...diiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 257-508 5.1e-67 221.4 In-house 56-291 (319) alignment 
Range on Protein: 257-508
Range on HMM: 56-291/319.0
GARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTnevergRNKCARYWPG
    .|| |||. |||.||...| |.  .  . .|||||| ...|    ... |||.|| |. |..|||.|||.  .  ||. |      ..||..||| 
anldqnkdknriinilafdknvvklerli.GeefsdyinasfvtGy..qrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywpl

-INETGEYGDISVQNATECINphYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQdinsKQDELVTTGNEPGPLIVHCSAGIGRTGT
 |... | ....|.  .|. .  |. |.. . .     ..|..  .||. |||.|||. |  .. ...    |   | .  |.. ...||||||.||||.
kivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvk....kvrhltskenhranivvhcsaGvGrtGv

FIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILY-H
.||.|.||. | .   |  ||. . .. .| ||. .||   ||||.| ..|  |
yivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_PTPN1_pd Subfamily PTPN1 235-509 1.1e-66 219.5 In-house 6-271 (290) alignment 
Range on Protein: 235-509
Range on HMM: 6-271/290.0
GFWEEFEQLQQQECRhLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsivgsDYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQ
 ...|. .  ..|..  |. .|  . ||...|||... |.||.|..|. .|      |||||. .  |..  ...|| ||| || |.. ||.|.|.. |.
rlykeiyldirkeas.dfptreaklpenrnlnryrdvspydhsrikleradn.....dyinaslv..eleeakrsyiltqGPlpntvdhfWqmvWeqksk

IIVMTTNEVERGRNKCARYWPGINETG--EYG--DISVQNATECINPHYIYREFIIHRIEdPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQd
 .||  . ||....|||.|||  .|.   ..    ..|.  .| .. .|. | . .. ..   . ||..|.|. .||| |||. |.. |.||... .   
avvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlk.tqetreilhfhyttwpdfgvpespaaflkflfkvresG.

elvTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
   .  .. || ..||||||||.|||...| .|  . ...  . |||.. .  .| .| |..|| .| .| | .||  .
...slssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 261-508 6.9e-66 217.6 In-house 24-255 (284) alignment 
Range on Protein: 261-508
Range on HMM: 24-255/284.0
ENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTnevergRNKCARYWPG-INE
.|| |||. .||.||...| |.  .  . .|||||| .|.|    ... |||||| |. |..|||.|||.  .  ||. |      ..||..|||  |..
qnkdknrighilafdknvvklerli.GeefsdyinasfitGy..qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

TGEYGDISVQNATECINphYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQdinsKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVI
. | ....|.  .|. .  |. |.. . .     ..|..  .||. |||.|||. |  .. ...    |   | .  |.. ...||||||.||||..||.
keerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvk....kvrhltskenhranivvhcsagvgrtgvyivl

DILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILY-H
|.||. | .   |  ||. . .. .| ||. .||   ||||.| ..|  |
dvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 227-511 8.5e-63 206.9 In-house 13-285 (290) alignment 
Range on Protein: 227-511
Range on HMM: 13-285/290.0
TGDIMGKAGFWEEFEQLQQQECRHlfSRKEGARVENKTKNRYKNILPFDHTRVVLH--GGDPSiVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDF
.| . |. || ..|..|.. |  |  . . |   .||..||..||.. |  |..|.  .|..     .|||| || |     .|.|||||| .. |. ||
nghakgnegfrnqfkmldsgeseh..tvtvgltssnkllnRfanivvyddnritLrpisghkD.CtneyinAcyikgy..kekkqyiatqgpvsntlvdF

WKMIWQESSQIIVMTTNEVERGRNKCARYWPGInETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQD
||.||||.. |||| ||..| |..||  |||   .| .|| .|..   | .  .|| |.. ..  .   ....| .|....|...|  ..| |.|. .. 
WkliwqekvtiivmltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillviee

INSKQDElvtTGNepGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
.. .|     .||  ....||||...||...|..... .| . .   |  .|.   ..  | |. |.|||.|||..... .|  ...
myktqrk...rgn..tsivvHCSdtvgrsavfcaaattinkckt...egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 232-506 2.3e-61 202.7 In-house 21-285 (325) alignment 
Range on Protein: 232-506
Range on HMM: 21-285/325.0
GKAGFWEEFEQLQQQECRhlfSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMI--W
 . ||  ||. |  ..     ..|  .. ||| |||.||....|..||||   . .   ||||||.|.  ..    . ..|.|  |..||||.|...  |
dqdgfahefgllpsddgi...akkvamkpenkaknrfknvvaldksrvvletkkdd.pssdyinasylrddk..kkdvflaaqaPltatindlWrlvldW

QesSQIIVMtTNEVERGRNKCARYWPGI-NETGEYGDISVQNAT-ECInPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINS
.  . ..|. .||.. | ..|| |||    .. ..| . |.  | | |   |..| . . ....  . | |  .....|.| ||.. | |..|.|| .. 
r..csvvvv.lneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkk.GetrsvkqfqlqswddmGvqkrpatlisilqlvka

KQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
 .. . .  .  .|..||||||.||||.|| .  .|. ...   |. |||   .. .|..|  ||.|  || ..| .. 
vservtantkastpilvhcsaGvGrtGvfislysalakvie...esrvdifgfvkklrkdrpsmvetvdqyiliyealv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 236-515 3.6e-61 201.7 In-house 21-283 (315) alignment 
Range on Protein: 236-515
Range on HMM: 21-283/315.0
FWEEFEQLQQQECrhlFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQI
| ||| .| . .    . .. .   .| .|||||||||.|..||.|   |  .  |||||| || .    ..| |||.|| |.....|||.|..||    
fseefhdlpdPdi...yrqrvaretinfkknryknilPldsarvklevidd.sPdsdyinasyiksv..dddkayiasqgPlkasvddfwrmvlqekvtt

IVMTTNEVERGRNKCARYWPG-INETGEYGDISVQNATECINPHYIYREFiIHRIEDpsNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvt
||| |.  |  . ||..|||    .. |.| |.|.      .   . |.. . |  .  ..| |  ..|. |||.||... ...| ..... ...     
ivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkse..esrtvtqfqftewPdkGvdkqtssllklikevkadn.....

tGNEPGPLIVHCSAGIGRTGTFIVIDillNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQL
 |..  .|.||||||.|||| .| ||   .|. |   .  ||. . .. .||.|  .||||..| |.| ..| ..  .  |
.gkkefsllvhcsaGvGrtGvvisid...evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 261-506 9.8e-61 200.0 In-house 2-236 (237) alignment 
Range on Protein: 261-506
Range on HMM: 2-236/237.0
ENKTKNRYKNILPFDHTRVVLHGGDPSivgSDYINANYISGeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINET
||| |||| ||  .||.||||.|   .   ||||||.|. | . |. |.|||.|| | .. .|||.|.|||   .||| |  .|. . || .|||  .. 
enkiknrygnivaydhsrvvlkgagsg...sdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

GEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELvttgNEPGPLIVHCSAGIGRTGTFIVID
  || ..|    .     |  | ... .     . | .. |.| .|||.||||   ..| | ..|  .   .    .| || |.|||||.|||| |.|||
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphv....sesgpwiihcsagvgrtgiflvid

ILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
 .|    |   .  |||   .. .  .|  ..||..|| |....||
amlr...qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 260-510 8.3e-60 197.3 In-house 41-277 (515) alignment 
Range on Protein: 260-510
Range on HMM: 41-277/515.0
VENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG-IN
  | .|||||||||.| .|| |   . .   |||.|| || .    ..| |||.|| ......|||....||    |.| |.  |  . ||..|||    
einfkknryknilPydsvrvklevindn.Phsdyfnasyipsf..dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

ETGEYGDISVQNATECINPHYIYREFIIHRIEDpsnQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELVttgnepGPLIVHCSAGIGRTGTFIV
.. ..| |.|.  .       | |.. . . .|    | |  .||. |||.|||..  ..| ..... ......        |||.|||||.|||| .| 
dsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt......hpliihcsaGvGrtGvvis

IDillNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
||   .|. .      ||. . .. .|..|  .|||..|| |.|  .| .. 
id...svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 255-509 3.4e-59 195.4 In-house 41-284 (297) alignment 
Range on Protein: 255-509
Range on HMM: 41-284/297.0
KEGARVENK---TKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYIsgevPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRnKCA
...   |.|    |.|||||||.|  || |.  . .   |||.|| ..    .| ....|.||   ..|..|||.|...|  ..||| ... || . |||
qpqtvaekkvnfeksRYkniLPydssRvkLaivndd.pdsDyvnasfv....kgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kca

RYWPGINETGeYGDISVQNATECINPHYIYREFIIHRiEDPSNQREVFHYHFKAWPDHGVPQ--DPGTVLSFLQDINSKqdelVTTGNEPgPLIVHCSAG
|||.    |  .||.||.  .      .| ||. . . ... ..| |  |.|  |||. |..  .  ..| ...... .      . .|  ||.|||.||
ryWsdkgvtt.fGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkd....fsqnaeg.PllvhclaG

IGRTGTFIVIDillNVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
.|||| .. ||   .|. .   | .|||   .. .| .|  .|||..||||||  .|  .
vGrtgvlltid...svvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 233-506 5.3e-59 194.7 In-house 23-276 (315) alignment 
Range on Protein: 233-506
Range on HMM: 23-276/315.0
KAGFWEEFEQLQQQECRHLfsrKEGARVENKTKNRYKNILPFDHTRVVL--HGGDPsivGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQ
| || ...| .   . . |   .   ..||| |||| ||...|..|| |     ||   .|||.|||.| |     ...|||.|| ......|||.....
kngfkqdyesipggqlhpl...dvakkienkqknryiniiaydksrvqlpllendp...hsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfe

ESSQIIVMTTNEVERGRNKCARYWPGIneTGEYGDISVQNATECINPHYIYREFiihRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQD
|    ||| || ||. ..|. .|||       || |.|    | .| .|  | .    .   .| |||. .|. .||| |||.   ... . . ..  ..
edigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhht

ELVttgnepGPLIVHCSAGIGRTGTFIVIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
. |      |...||||||.||||||| .| .|.   |   |  .|. ..|. ||..| .|||. .||.|.|  .|
nsv......gaivvhcsaGvGrtGtfitldavld...qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 227-515 7.6e-59 194.0 In-house 13-284 (287) alignment 
Range on Protein: 227-515
Range on HMM: 13-284/287.0
TGDIMGKAGFWEEFEQLQQ-QECRHLFSrkEGARVENKTKNRYKNILPFDHTRVVLHGGDPsivgsDYINANYISGEvpGSEKHYIATQGCLPTTINDFW
.|   |. || . |  |.| .. ..      .   .|| |||...||. |  ||.|.| .|     ||||| .| |    ..|..|.... .  |. .||
kghakgnegfknqftvleqvtqredevt..hniasqnkdknRltqilvpdnyrvllkgehp.....dyinavfidgy..kekkafiiaesPmfntarnfW

KMIWQESSQIIVMTTNEVERGRNKCARYWPGINEtGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDI
|.|...  ..||| ..| |  ...| .|||  .    .|. ...   | .| .|| |.. ... .  .....|  |.. .|...|  ..| |.|  ... 
kliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem

NSKQDElvtTGNepGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQL
. .|      ||  ....||||...||...|. ... .|   ..|    .|. . ..  | |. |.||| .||||..  .| .... .  
yktqrk...rgn..tsivvhCsdtvGrsamfcaaattinkckteG...viDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 218-509 1.3e-58 193.5 In-house 9-279 (439) alignment 
Range on Protein: 218-509
Range on HMM: 9-279/439.0
DRVSELEKETGDImgkagFWEEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYISGEVpgSEKHYIATQGCL
. | .|.|.  .|     | |.||...  .  .       |.  ..||||||.. .||||||.|.   | .  | ||||||| |     .| ||||||  
ehvekldknkqei.....fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqe.ipgvphshyinanyikGyy..ddklyiatqgpk

PTTINDFWKMIWQESSQIIVMTTNEVERGRnkcarYWPGINETgEYGDISVQNATECINPHYIYREFIIHRIEDPS-NQREVFHYHFKAWPDHGVPQDPG
  | .|||...... .  ||| || ||  .     |||  .|.  ||||.|.   .   |.|. | | .    | . ..| |...|. ||||. || .  
kettddfwrlviekktvtivmltnlvesyk.....ywpsdaev.cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqas

TVLSFLQDINSKQDElvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
 || ||. ||| .|.     .| ||..||||||.||||| | .|| |.   |   |  |||.  ....| ||  |||.  || |.| ..|  |
hvldflrainsandk.....eeygpvvvhcsagvGrtGtiialdiale...qlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 238-515 9.4e-58 190.3 In-house 14-283 (287) alignment 
Range on Protein: 238-515
Range on HMM: 14-283/287.0
EEFEQLQQQECRHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIV
.|...|..      .  |.   . .  |||| ..||.|.|||.|   ..   |||||||||...     .. .||.|| ...|..|||...... |  ..
kevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa.ege.lGsdyinanyvasyt..ddeafiaaqgPiaatvrdfwravletrsasvi

MTTNEVERGRNKCARYWPGINETGEYGDISVQNA-TECINPHYIYREFIIHRIEdPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSkQDELVTTG
. | ||| .|.|| .|||  .     |  ||     .  .|.|  | . .  .|   . | |  ... .|||....     .. |  |..  . ||   .
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidle.trearvvkqldllswPdkvlaPtavglirfvldvkq.hielarda

NEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQL
.| |||.||...||||.|... . .|.. . . |    ||. ...  .| .| ..||.  |....| ..  . .|. ||
sevGPlvvhddvGiGrsGillatlvlvsrledlG...rvdvaavvirlreyraalvqavvqlrllyealvtyyktnpql
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 261-506 1.6e-57 189.4 In-house 6-237 (239) alignment 
Range on Protein: 261-506
Range on HMM: 6-237/239.0
ENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPgiNET
 ||.|||| ||. .||.||||         ||||||.|.  .  || | |||||||. ..  |||.|.|||   .||| |  .|  ..|| .|||  . |
vnkaknryanivtydhsrvvleklsnd.phsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dst

GEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINskQDELvtTGNEpgPLIVHCSAGIGRTGTFIVID
 .| .. |      .   || | |.. .. . ...| |..|||  |||.||||   .|| . . |   .| |   |    | ..|||||.||||.|.|||
skycnlrvtlrktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkit..kdsl..pgar..pwvihcsagvgrtgaflvid

ILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
 .|    .|     |||   .. .| .|  |||| .|| |.. ..|
amlrqakkq...ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 261-506 1.7e-57 189.3 In-house 7-238 (239) alignment 
Range on Protein: 261-506
Range on HMM: 7-238/239.0
ENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPgiNET
 ||.|||| ||. .||.||||         ||||||.|.  .  || | |||||||. ..  |||.|.|||   .||| |  .|  ..|| .|||  . |
vnkaknryanivtydhsrvvleklsnd.phsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dst

GEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINskQDELvtTGNEpgPLIVHCSAGIGRTGTFIVID
 .| .. |      .   || | |.. .. . ...| |..|||  |||.||||   .|| . . |   .| |   |    | ..|||||.||||.|.|||
skycnlrvtlrktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkit..kdsl..pgar..pwvihcsagvgrtgaflvid

ILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
 .|    .|     |||   .. .| .|  |||| .|| |.. ..|
amlrqakkq...ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_PTPRN_pd Subfamily PTPRN 253-506 1.4e-55 183.1 In-house 47-289 (297) alignment 
Range on Protein: 253-506
Range on HMM: 47-289/297.0
SRKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYISGEVPGsEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCAR
... . . .| .|||.|..||.||.|| |.  . |   ||||||  |  . |  .  |||||| |..|. |||.|.|.. . .||. |.  | | ..|.|
tkevakaeknvkknrskavlpydhsrvklke.easaeksdyinasaildhdpr.apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckr

YWPGiNETGEYGDISVQNATECIN-PHYIYREFIIHRIEDpSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSkqdelVTTGnEPGPLIVHCSAGIG
|||  . .  |.   |.  .| |    |. | | .  ..  |. | |  .|| .||..|||  . ..| | . .|         |    |..||||.| |
ywpd.eGsevyhiyevhlvsehiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrkvnk.....syrG.rscpivvhcsdGaG

RTGTFIVIDILLNVMMQqGFeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
|||..|.||..|| ... |   ..||  ... .| ||.|.|.|..|..|.. .. 
rtGvyilidlvlnrllk.Gv.keidiaatlehlrdqrpglvktkdqfefaltava
0051429 (Phosphotyrosine protein) phosphatases II 291-511 9.4e-55 181.4 In-house 4-227 (272) alignment 
Range on Protein: 291-511
Range on HMM: 4-227/272.0
SDYINANYISGEvpGS---EKHYIATQGCLPTTINDFWKMiWQESSQIIVMTTNEVERGRNKCARYWP-----------GINETGEYGDISVQNATECIN
|.||||....|   |.   .. .....|.|| |..|||.. ...    ||. ..|.||||.|| ||||              .| .||...| .  | . 
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPgtVLSFLQDINSkqdelvttgnePGPLIVHCSAGIGRTGTFIVIDILLnvmMQQGFEADVD
..||.||...... .... |||.|.|. .||||||||..  .|..|. ...           .||..||||||..||||......||   .. . |. ||
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...........ggpvlvHCsaGkdRTGtvvalllll...lgvsletivd

--------IQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
        ...|.. .|||| |.||||.||.|.|. .|  ...
dYlltnlyleeaveelraqrpgavqteeqylflyeallellrs
0041856 (Phosphotyrosine protein) phosphatases II 262-511 3.7e-53 175.1 In-house 1-173 (182) alignment 
Range on Protein: 262-511
Range on HMM: 1-173/182.0
NKTKNRYKNILPFDHTRvvlhggdpsivGSDYINANYISGEVPGSEkhYIATQGCLPTTINDFWKMIWQESSQIIVMTTnevergrnkCARYWPginetg
|..||||..|||.||.|           ..||||||.. |  |...  .||||| |. |..||..|....  ..||. |         . .|||      
nldknrysdilpydhsr...........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp......

eygdisvqnatecinphyiyrE-FiihriedpsnQREVFHYHFKAWPDHGVPQdPGTVLSFLQDINSkqdelvttgnEPGPLIVHCSAGIGRTGTFIVID
                     | .          .|....|..  |||||||  . ..|.|......          |.|| .||||||.|||||.....
.....................ell..........erlgiqylylpwpDhgvpd.ldelldfieevle..........eggpvlVHCsaGvgRtgtlvaay

illnVMMQQgfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
    .|...    .|... |..||| .|.|||.|..|| |... .|.... 
....lmkkl....gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 234-510 1.8e-51 169.6 In-house 15-294 (301) alignment 
Range on Protein: 234-510
Range on HMM: 15-294/301.0
AGFWEEFEQLQQQECRHlfsRKEGARVENKTKNRYKNILPFDHTRVVLHGGDP-SIVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQES
 .| |....|...| ..    . | . |||. ||.||| ..|. |..|.     ..   .||||.||.|    ..|..||.|| .  |. |||..|||| 
nkfeeqykelkegedks...ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys..ekkkfiaaqgpmkktlvdfWrliwqek

SQIIVMTTNEVERGRNKCARYWPG-INETGEYGDISVQNATECINPHYIYREFIIhRIEDPSN---------------QREVFHYHFKAWPDHGVPQDPG
 . ||| ||. |. ..|| .|||   .|. |.| ..|.   |.. | .. |.. . .|.| ||                ..|  ..   ||..|| ..| 
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnv.kiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

TVLSFLQDINSKQDELvttgnEPGPLIVHCSAGIGRTGTFIVIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
|||  ..|.  .|        . ||..||||....|.|... ..| |    |   |  ||.   .. || .. |.|.| .|| ..|  |   ..
tvLqviddvihrqqki.....gggpvvVHCSdtVsrsGvYcsvsiglE...QckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 239-506 5.5e-50 164.8 In-house 11-263 (283) alignment 
Range on Protein: 239-506
Range on HMM: 11-263/283.0
EFEQLQQQECRHLFSRKEGARvENKTKNRYKNILPFDHTRVVLHGGDPsivgsDYINANYIS-GEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIV
 .|.|..    .| .  . |. |||.|||...|.| |  || |.   .     ||||| .|   .    .| ||..|. |  |. |||||...|    ||
frevlkrlsvpdldadiasad.enkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MTTNEVERGRNKCARYWPGiNETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGvPQDPGTVLSFLQDINSKQDElvttgN
| |.  |  | ||..|||  . . .||.  |    |  .  .| .|....      ..  . || .  | . | .| .   |  .  . |.| |     .
mltklqedlrikCsqyWPk.rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqte.....s

EPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
. ||..||||.|||||..|| .   .. ..    |. ||.   .. .| || ..||| .|||.|.  .|
kkgPivvhCstgiGrtavfiaasasvkdalt...esvvdvfavvkimreqrmmavqtldqyklvhelvl
0049772 (Phosphotyrosine protein) phosphatases II 256-518 6.8e-50 165.9 In-house 40-289 (314) alignment 
Range on Protein: 256-518
Range on HMM: 40-289/314.0
EGARVENKTKNRYKNILPFDhTRVVLhgGDPSIVGSDYINANYISGEvpgseKHYIATQGCLPTTINDF----------WKMI--WQESSQIIVM-----
 .  ..|..||||..|||.| .||.|  .  .. |||||||.|..|      . .||||| |. |..||          |.|.  ..  . .|||     
vadlflnrdknryldilpad.nrvil..pglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------TTNEVERGRNKCARYWPGINetgeygdisvqnatecinphY-------IyrefiihriedpsnQREVFHYHFKAWPDHGVPqDP
                 ..  ..|   .|.... ..                                           .|....|.   .||...| ..
ladelsrLdaAlgKtpllildgngneptaadlellk....................eelydpelf..............erlgikylripvpDgsap.ll

GTVLSFLQDINSKqdelvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMmqqgfeaDVDIQRAIQLVRAQRS-----GMVQTEQQYKFVYRSILYHIE
  ...||. |..         ...||..|||.||.||||||.|...|.  .       .|... |.. ||..|.     |.... .|| |... .|....
edfdeflefieea........dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqyefilealleylk

TQRQLSES
.... .|.
flkkfyey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 259-509 6.9e-48 158.0 In-house 30-295 (297) alignment 
Range on Protein: 259-509
Range on HMM: 30-295/297.0
RVENKTKNRYKNILPFDHTRVVLHGGdpsIVGSDYINANYISGEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGIN
|     ||||..|| .| ||| | ..   | ..|||||.|.      .. .|| .|| | .|..|||......  ..||| ..  | ||.||| ||| ..
rnsslrknryrdilatddtrvkllrv...iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

ETG-EYGDISVQNATEC---INPHYIYREFIIHRiedpSNQREVFHYHFKAWPDHGVPQDPGTVLSF--------------LQDIN-------SKQDELV
. . . ||. |.  ..     .  ..    .|.|    |..| | |  | .||||||| |   .  |              |  ..        . . | 
qerlkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslr

TTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgFEAdvDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
.    . .|.||||||.||.|  .  |..|... .. .    |..  .. .| ||. .||| .|....|  .|  .
aemprnayllvhcsaGvGrsGvvvlsdvilaklrkk.rip..dvaailsilreqrarlvqtleqfellydavlkkl
subfamily_ptpA1_pd Subfamily ptpA1 253-464 5.5e-47 155.4 In-house 38-254 (418) alignment 
Range on Protein: 253-464
Range on HMM: 38-254/418.0
SRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEVPgseKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCAR
   || .  | .|||| |||| .|||| |.  .    |||||||||| |  |   |..|.||| || || |||.|.|..  .|||| . | |  | || |
etsegdkkhntsknrytnilpvnhtrvqlkkiq.dkegsdyinanyidgayp...kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YWPGI---NETGEYGDISVQNATECINPH----YIYREFIIHRI--EDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELVTTGNEPGPLI
|||     ..   ||.      |  ..         || | . |      . |.. .|... |||| .|.    .  .|. |  .|.... . .   |.|
ywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VHCSAGIGRTGTFIVIDILLN
||||||.||||||    |...
vhcsagvgrtgtfctavimmk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 234-515 1.2e-46 153.9 In-house 20-242 (392) alignment 
Range on Protein: 234-515
Range on HMM: 20-242/392.0
AGFWEEFEQLQQQEcrhLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESS
| | ||| .| . .   .. .. . .  |. |||||||||.| .||.|   |  |  |||.|| || .    .|| |||.||  .....|||.|..||  
alffeefhdlpgpd...iypqtvaqkeinlkknryknilpydsarvklevid.dipdsdylnasyipsf..dnekayiasqgpnaaslddfwrmvfqenv

QIIVMTTNEVERGrnkcarywpginetgeygdisvqnatecinphyiyrefiihrieDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelv
  |.| |.  |                                                 ..| |  .||  |||..||.   ..| |.......     
ttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf....

ttGNEPGPLIVHCSAGIGRTGTFIVIDILLNvmmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQL
  |.   |||.|||||.||||  | || ..    .      ||.   .  .| .|  ||||..|| |.| ..|  .  .  |
..Gqythpliihcsagvgrtgvvisidsvva...hakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntl
subfamily_CG7180_pd Subfamily CG7180 243-510 5.8e-46 151.5 In-house 29-291 (296) alignment 
Range on Protein: 243-510
Range on HMM: 29-291/296.0
LQQQECRHlfsrkeGARVENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNE
|.. .|..      | | ||. |||. ...|.|..||||.  |     |||||| |. . .   .| || |..    |...||.....| .. .|. |..
leigdCag......glrkenreknrdvkvvPyDynRvvLekldGe.eksdYinavyvdsfl..kkkeyivteapkketvdefWrlvydeeisavvvLtkt

VERGRnKCARYWPGINeTGEYGDISVQNATECINPHYIYREFIIHRI---------EDPSNQREVFHYHFKAWPD-HGVPQDPGTVLSFLQDINSKQDEL
 .  . ..  |||      .||.| |.  .|   ..   |.| . .          .   ..| | ..... |.  . ||    ... ... ... ... 
fdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv

vTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeaDVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIE
    .| ||..|..| | .|.| .. ||. |. . ...    ||. .|.. .| .| ..|.. ..||..|  .| .. 
.dedpeegPvvvvssdGasRsGvylaidanlelvekee...evdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
0036282 (Phosphotyrosine protein) phosphatases II 290-502 3e-45 149.4 In-house 1-163 (174) alignment 
Range on Protein: 290-502
Range on HMM: 1-163/174.0
GSDYINANYISGEVPGSekHYIATQGCLPttindFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGinetgeygdisvqnatecinphyiyrefiihri
|||||||..... .  .  ..||.||.|.     ||.|.........|| ..|.|.|. || .|||                                  
gsdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

EDPSNQREVFHYHFKAWPDHGVPQDPGtVLSFLQDINSKQDElvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMqqgfEADVDIQRAIQLVRAQRS
   .  |....|..  ||||||| ..  .|.|.. ... . |     .. ||..||||||.|||||.......|  ..    |  ||. . .. .| ||.
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrp

GMVQTEQQYKFVY
|||||..||.|.|
gmvqtpsQyrfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 254-506 4.8e-45 148.4 In-house 48-280 (290) alignment 
Range on Protein: 254-506
Range on HMM: 48-280/290.0
RKEGARVENKTKNRYKNILPFDHTRVVLHGGDPsivgSDYINANYISGevpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARY
||   .  . .|||||..   | |||.|. | .     ||. |||. |     .  .| ||| |  |. |.|.|. ||    |||  . .| |. ||..|
rkifdkntefkknrykdvvcndktrvilkdGyd....GdyvhanyvkG....lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPGIN-ETGEYGDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINskqdelvttgNEPGPLIVHCSAGIGR
.|  . |.  .|.|.|  . |  .   | .  .  |  |   .  . |.. |.|||. |..   ..|  |. .           . .||..|||||||||
ypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr..........kasGpvvvhcsaGiGr

TGTFIVIDILLNVMMQqGFEadVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
||||. |.. |..... | |  .|.   .. .|  | . || . ||  . . .|
tGtfvaievglqilld.Gke..ldlldlvralrnsrlnsvqvdiqylalveill
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 238-512 4.4e-44 145.7 In-house 20-281 (307) alignment 
Range on Protein: 238-512
Range on HMM: 20-281/307.0
EEFEQLQQQECRHLFSrkeGARVENKTKNRYKNILPFDHTRVVLHGGDpsiVGSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIV
.||..| ...   .      |   |  ||||...   |..|.|..      . |||| |||.   .    |..|..|| | .|. .|| |. ||  . ..
defrvlakktpegvtv...eafsantdknryqdvkcqdkgrivvkfdg...lasdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesvi

MTTNEVERGRNKCARYWPGINE-TGEYG----DISVQNA-TECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDe
|  . .| .. || .|||  .  .  .|     |||.|  .. . |   . .    ...  .. | . |. .. |||.||||   | . .|. .. ... 
mlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn.

lvttgnepgPLIVHCSAGIGRTGTFIVIDILLNVMMQqGfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL-YHIETQ
         |..||||||.||.|| . | .. . |.. | .   |... .. .|.||   .||| || ...| .| | .|  
.........pvvvhcsaGvGrsGtivaislvqdkmia.G.inckdmkklveelrsqrhyaiqteaqylylhrvlleyflely
0043147 (Phosphotyrosine protein) phosphatases II 290-502 6.5e-44 145.0 In-house 4-154 (172) alignment 
Range on Protein: 290-502
Range on HMM: 4-154/172.0
GSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEvergrnkcarywpginetgeygdisvqnatecinphyiyrefiihRI
|||||||.|... .    ...|||||.|. |..|||.|....  ..||. |..                                               
gsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................ly

EDPSNQREVFHYHFKAWPDHGVPqDPGTVLSFLQDINSKQdelvtTGNEPGPLIVHCSAGIGRTGTFIVIDILLnvmmqqgfeADVDIQRAIQLVRAQRS
  .  .|....|..  ||||||| ..  .|.||. |....       .. || .||||||.|||||.......|          ..... |..|||..|.
dpellerlgiqylylpwpDhgvp.llellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRp

GMVQTEQQYKFVY
|.||...||.|.|
gavqnpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 290-508 1e-43 144.4 In-house 11-172 (176) alignment 
Range on Protein: 290-508
Range on HMM: 11-172/176.0
GSDYINANYISGEvpgsekHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINETGEygdisvqnatecinphyiyrefiihri
..||||||.| |       ..||||| || |. ||..|....  ...|. |.||| || ||..||| . . |                            
dldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

edpsnqrevfHYHFKAWPDHGVPQDpGTVLSFLQDINSKQDElvttGnepGPLIVHCSAGIGRTGTFIVIDillnvMMQQgfEADVDIQRAIQLVRAQRS
          .|..  |||||||..   .|..|. |.. ..|    |   || .||||||||||||.....     ...   | ..... |..|||.||.
..........qylhlpwpDhgvpdl.elllellefirealke....g...gpvlVHCsaGigRtgtlvaay.....llel..ekglsveealalvreqRp

-GMVQTEQQYKFVYRSILYH
 |.|||..||.|.|. .|..
lgavqtpeQyrflyefelll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 258-519 2.9e-42 139.5 In-house 44-297 (305) alignment 
Range on Protein: 258-519
Range on HMM: 44-297/305.0
ARVENKTKNRYKNILPFDHTRVVLHGGDPsivgSDYINANYISgeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGI
   ... |||||..  .|. || |.|  |     .|| |||.|   |   | .| ||  |  |  ||| | .|.  . | |  | .|.| .||. |..  
keaqeagknrykdvgcldnnrvklegpwp....heyihanyvs..tptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfask

NET----GEYG-DISVQN-ATECIN---PHYIYREFIIHRIEDPSN-QREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvttgnepGPLIVHCS
..      | |  |||.  ... ..   .     .  .  || | . .| | |||.  ||| |||    ..| .|..  . .          ||..||||
dkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk..........gpivvhcs

AGIGRTGTFIVIDILLNVMMQQGFEAdvDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQLSESN
|||||||. .... .|. ...       | .. .| .| ||   .||..|| ||.. || ... .. | |. 
agigrtgsvvmleyildqllagqiie..dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeev
0049260 (Phosphotyrosine protein) phosphatases II 308-502 4.6e-41 135.4 In-house 9-143 (152) alignment 
Range on Protein: 308-502
Range on HMM: 9-143/152.0
KHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWpginetgeygdisvqnatecinphyiyrefiihriedpsnqrevfHYHFKAWP
...|||||..| |..|||.|...   ..||| |...|.|. ||..|.                                             .|..  ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwp

DHGVPQDPGTVLSFLQDINSKqdelvtTGNEPGPLIVHCSAGIGRTGTFIVIDILLnvmmqqgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVY
|||||...  .| .|. |.          .. || .||||||.|||||.......|          .|... |..|||..|.|.|....|..|.|
Dhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 236-517 2.1e-38 126.6 In-house 13-277 (281) alignment 
Range on Protein: 236-517
Range on HMM: 13-277/281.0
FWEEFEQLQQQECRHLFSRKEgARVENKtKNRYKNILPFDHTRVVLHGGDPSIVGSDYINANYISGevPGSEKHYIATQGCLPTTINDFWKMIWQESSQI
| .|| .|  .    | .  .   |.|| |||| ||  .| .|| |.   |    .||| ||||    |  .. || |||    |  |||.||||| .  
fkqefsnlpgdppsdlctvfn.qpvnnk.knrylnipcldisrvqlkvkmpnknstdyihanyirs..pflkrgyiltqgpkketradfwrmiwqentta

IVMTTNEVERGRNKCARYWPGINET-GEYGDISVQNATECINPHYIYREFIIhriEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvt
|||  . .|  |.||| |.|       ..  .||.     .|   .   . .       . | . |. .| |||  ||.    .|  |. | ..      
ivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl...syegetrlithwlwkewpdwqvpessevmlkilrkirars.....

TgnepgPLIVHCSAGIGRTGTFIVIDILLNVMMQQgFEaDVDIQRAIQLVR-AQRSGMVQTEQQYKFVYRSILYHIETQRQLSE
|     | ..|||||.||.||.. ..| |. .  . |    ||.. .  .| . |.  ||| ||| .... .|    . .|..|
t.....ppvihcsagvgrsgtlmaveialqsihsh.ft.lpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqite
0051082 (Phosphotyrosine protein) phosphatases II 291-504 3e-37 122.8 In-house 3-148 (151) alignment 
Range on Protein: 291-504
Range on HMM: 3-148/151.0
SDYINANYISGEvpgsekhYIATQGCLPttinDFWKMIWQESSQIIVMTTNEVERGrnKCARYWPGINetgeygdisvqnatecinphyiyrefiihrie
|||||..|. |        .....| |.    ||.......  . ||. ..|.|||  .|..|.|  .                                
sdyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

dpsnqREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSkqdelvttgNEPGPLIVHCSAGIGRTGTFIVIDILLnVMmqqgfeadVDIQRAIQLVRAQRSG
     .||.|...  |||.|.|. . .||.||. ...         ...||..||||||.|||||.......|  .        |... |.. .|..| |
.....ievlhipildwpdpglplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylml.lg........vsleealeeyrlkrpg

MVQTEQQYKFVYRS
.||..||. |... 
vvqpnqqflfqlfa
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 252-509 5.1e-37 122.1 In-house 46-290 (305) alignment 
Range on Protein: 252-509
Range on HMM: 46-290/305.0
FSRKEGARVeNKTKNRYKNILPFDHTRVVLHggDPSivGSDYINANYISGEVpGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCA
|  .. | . ..|||||...   |.. | |.  .||   |||| |||.   .   || .|..|| |  ||..|| |. |.  . |||  . || |. |||
fnanqsadi.aitknryqdvpcqdqsavkld..kps..psdyihanyvgcpm.ipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

RYWPGIN-ETGE-YGDISVQNATeCINPHYIYREFIIHRIEDP---SNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelVttgnepgPLIVHC
.|||  . |  |  . | |.| .   .|     |  |  ..     ...  | | ..  ||| |||    | | .|  |   .   |       |..|||
qywpaaqgeklelksgivvenvs.gskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk...v.......pivvhc

SAGIGRTGTFIVIDILLNVMMQQGfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILY-HI
||||||||| . |. .|. . ..       .   .. .| ||.  .|.. || |..| .|   .
sagigrtgtivaieyilekiaenk..pcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
0044763 (Phosphotyrosine protein) phosphatases II 273-504 5.1e-35 116.1 In-house 1-166 (178) alignment 
Range on Protein: 273-504
Range on HMM: 1-166/178.0
PFDHTRVVLHGGdPSIVGSDYINANYISGEvpgsekHYIATQGClpttiNDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINEtgeygdisvqnat
|.|.|||.|.   . . .||||||..| .        |......      |........  . ||. |.|.|.|..|| .|||  ..             
pldrtrvllsnl.eglersdyinaseilpg......lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............

ecinphyiyrefiihriedpsnqrevFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDelvttgNEPGPLIVHCSAGIGRTGTFIVIDILLNVmmqqgfe
                          ..|..  .||||||. .  .| |.. |.. .|      ...|| .||||||.||.||........         
..........................iqylhipipDhgvpdllehflefvefieeald......ekggpvlVHCsaGvgRsgtlvaaylmkkl.......

aDVDIQRAIQLVRAQRSgMVQTEQQYKFVYRS
 ..... ||.|||..|. .|... |....|. 
.glsleeaielvrerRp.ivpnpgqlrqLyef
subfamily_CG42327_pd Subfamily CG42327 237-428 1.2e-34 114.4 In-house 8-193 (319) alignment 
Range on Protein: 237-428
Range on HMM: 8-193/319.0
WEEFEQLQqqecrHLFSRKEGARVENKTKNRYKNILPFDHTRVVLHGgDPSIVGSDYINANYISGEVpGSEKHYIATQGCLPTTINDFWKMIWQESSQII
 |||..|       | .| .   |  | |.|. |..|. .|||||.   ..   . |..|.|. |    .. .|||.|  |  .  |||...|.  |..|
aeefrdlP.....qliaradevPvtskdksrvinvvPlPetrvvlqr.igdddkdeyldasyvrGyd.dapnsyiaaqvsledsssdfwrtvweqqsrvi

VMTTNEVERGRNKCARYWP---GINETGEYGDISVQNATECINPHYIYREFIIHRIEDpSNQREVFHYHFkAWPDHGVPQDPGTVLSFLQDINSK
|  |.  | | ..||.|.|   . ..|  |||| |      .. .|.   ....|... .. ||. || .  |.. .|| .. .... | ...| 
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdk.eesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 259-511 2.6e-34 113.5 In-house 30-261 (267) alignment 
Range on Protein: 259-511
Range on HMM: 30-261/267.0
RVENKTKNRYKNILPFDHTRVVLHGGDPSivgsdYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEverGRNKCARYWPG-I
  .|. .||. . ||.|.|||.|   .       |||| |. |     ....|.||. |  || ||...| ..   .||. |.    . ..  ..||  .
aeknqernrlddnlpyddtrvilrtkeee.....yinasyvegyk..tknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkm

NETGEYGDISVQNATECINPHYIYREFIIhRIEDPSnQREVFHYHFKAWPdhgVPQDPGTVLSFLQDINSKQDelVTTGNEpgPLIVHCSAGIGRTGTFI
 .. .| |..|. . |  .  |    . . .... |  ..|  |..| |    .  .    |  |  | .|..  .  ||   ||.|.||.|.||.|||.
gqakkyqdltvehslekeendyqiitlel.kfknes.ahnvtlyyykkwn...intnnkpylkplfgilaknq..lengnr..PlvvacsdGvGrsGtfl

VIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
|||  |. . .   |  .||   .. .| || |.|.| ..| ......  . | 
vidsqlerakt...egvsdifdflrkirsqriglvdtkeryiyihellaeyaeg
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 260-511 2.8e-34 113.5 In-house 41-273 (288) alignment 
Range on Protein: 260-511
Range on HMM: 41-273/288.0
VENKTKNRYKNILPFDHTRVVLHgGDPSIvgsdYINANYISgeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG-IN
..| |..||.|.   | ||| |.  ||      ||.|| .|      ... | .|  | .||. .|||. ..  . ||| .. .|.|..| | |.|  . 
ianptrdryenlprcditrvkls.ddpdf....yiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG

ETGEYGDISVQNATECINPHYIYREFIIhRIEDPSNQRE-VFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDelvttgnepgPLIVHCSAGIGRTGTFI
|.  .| .  .   .  . . . .  .. ||. . ...  | . |.. |.|.|||..  . | .|. ..| |           |..||.|||.|||||.|
ekarigrlctvvkkkradidklvkvsll.riskegeekvivkilhlleWdddgvPenylsplrllevlkslqk..........PivvhssaGvGrtgtli

VIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIET
.| | |...     . .. |.. ..  |..|   .|||.|| .|.| .|...  
lilialeslrl...ddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 258-519 7.8e-34 111.6 In-house 48-300 (310) alignment 
Range on Protein: 258-519
Range on HMM: 48-300/310.0
ARVENKTKNRYKNILPFDHTRVVLHGgDPSIVgSDYINANYISGEVpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGI
|  ..  |||| ...  | .|| |.  | |    ||| |||.  .     . .| .|| |  || |||.||.|| .. |..  . .| || ||  ||| .
aykkymhknrysdvvcldtsrvklki.dksry.edyihanyvktny..lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl

NETGEYGDISVQNATECINPHYIYR---EFIIHR---IEDPSNQREV--FHYHFKAWPDHGVPQDPGTVLSflqdinskQdELVTTgNEPGPLIVHCSAG
  |  || | | | .|  .   |      |.       |.|.| .|.     ..  ||| |||..    .         |  |..     || .||||||
gvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp........q.rllaq.vrhgpcvvhcsag

IGRTGTFIVIDILLNVMmQQGfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQRQLSESN
..|... . ... .. . ..|    ||..  .  .. .|   .||| || .. |  .    .... .|. 
kdrlyvvvalklkidkl.drg..lkvdaeevktellksraiciqtelqyliidrvriifargetevaeki
PTPc_DSPc_SM00012 398-507 1.9e-33 110.2 In-house 2-105 (105) alignment 
Range on Protein: 398-507
Range on HMM: 2-105/105.0
VFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELVTtgnePGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGfeADVDIQRAIQLVRAQRSGMVQTEQQ
| |||...|||||||...  .|..|....... .  .     .|..||||||.||||||...||||. ....     |||.. .. .| ||.||||||.|
vkhyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeq

YKFVYRSILY
| |.|| .|.
ylflyralle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 262-506 3.7e-31 103.1 In-house 35-267 (285) alignment 
Range on Protein: 262-506
Range on HMM: 35-267/285.0
NKTKNRYKNILPFDHTRVVLHGGDpsivgSDYINANYIsgEVPGSEK-HYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG-INE
|   ||| ..   . |||||.  |      ||| |...   .|| ..  ||.||| || |..|||.||.||    ..|    .| | .||| |.|  . |
npdlnryadvrcieetrvvlknhd.....rdyihaswm..rmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

TGEYGDI--SVQNATECINPHYIYREFIIHRIEDPSNQ-REVFHYHFKAWPDHGVPQDPGTVLSFLQDINSkqdelVTTgnEPGPLIVHCSAGIGRTGTF
  ..|    .. .. |      |.  . .   || |..   . | .   |||.  |.|   .. . . ..      |    .  |. ||||||.||| ||
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.....vnp..kekpicvhcsagvgrtatf

IVIDILLNVMMQQGFEADVDIQRAiqlVRAQRSGMVQTEQQYKFVYRSIL
. ||     .|..     .|| |    .|| |   ||.  |. |.|  ..
vgidyatirimenpniemldivre...mramrfqavqshmqflflyvvlm
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 260-368 5.9e-31 102.4 In-house 45-160 (350) alignment 
Range on Protein: 260-368
Range on HMM: 45-160/350.0
VENKTKNRYKNILPFDHTRVVLH-------GGDPSIVGSDYINANYISGEVPGSEK----HYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRN
||  .|||||||||..|.|| |.       . . |. ..|||||||.. .... |     .|||||. || |..||.|.| .   ..|.. |..|| ...
velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnle

KCARYWPgineTGEYGDISV
|| |||.     |.| || |
kcyrYWq....egsydditv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 263-509 2.6e-30 100.2 In-house 51-281 (301) alignment 
Range on Protein: 263-509
Range on HMM: 51-281/301.0
KTKNRYKNIlPFDH-TRV-VLHGGDpsIVgsdYINANYISGEvpGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINE-
| |.||... | .  | | |.  |    |    | ||.|. .  |  ...||||| |. | .||| |. |   . ||| ...||.  .||. | |   . 
kdkhryptv.PckPstavevivdGk..rv...Pihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkise

T---GEYgDISVQNATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLqdinskqdELVTTGNEpgPLIVHCSAGIGRTGTF
.   | . .| ..|    .| . . |.. ..   .  . | | || .. |.|.|||.    .  ..        |||   ..  |..|||||||||. .|
kldigrf.kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm........elvkksek..PivvhcsaGiGrsvaf

IVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
|  ..| . .     .  .....|.. .| .|   |||..|  ..    .| .
igteylarevea...dptieltealkhlrehrwngvqtnsqlywmtlGtvyrl
subfamily_egg_pd Subfamily egg 256-509 4e-29 96.3 In-house 34-270 (307) alignment 
Range on Protein: 256-509
Range on HMM: 34-270/307.0
EGARVENKTKNRYKNILPFDHTRVVLHGGDPSIVGsDYINANYISGEvPgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERgrNKCARYWP
. |  .|..| | | .   | .|| |.      .. |.| ||...|. |    ..| .|  |  | .|||.|..||  | ||| |  .|   ..|  |||
taasdnnlekarskrvhckdssrvklelrrGqyld.dfihanrvkGk.p.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

GI-NETGEY--GDISVQNATECINPHYIYREFIIHRIEDPsnQREVFHYHFKaWpDhgvpqdpgtvLSFLQDINSKQDELVTTGNEPGPLIVHCSAGIGR
   ...  .  | . ..|     ..  ..|   .. .     . | |  |.. . |          . .. |. |    |    |   | .|..  |. .
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwq.g.d..........vnnssdvysplrvlrklrnlskpvvvqdilGvsk

TGTFIVIDILLNVMMQqGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
..|.. |.| |  ... |      ..||....| .|   |..  .| |||| .|. .
aatlvaieiallsllr.Gpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
0048076 (Phosphotyrosine protein) phosphatases II 388-505 5.8e-28 92.8 In-house 37-139 (145) alignment 
Range on Protein: 388-505
Range on HMM: 37-139/145.0
RIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvttgnePGPLIVHCSAGIGRTGTFIVIDILLNvmmqqgfeADVDIQRAIQLVRAQ
  | .   |....|..  |||||||... ..|.||. |.. ..|       .|| .||||||.|||||.......|          .|... |..|||.|
tselellerlgiqylylpwpDhgvpdllellleflefieealke.......ggpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsq

RSGMVQTEQQYKFVYRSI
|.|.|....|..|.|. .
rpgavpnpgqlrflyefe
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 307-503 9.2e-28 91.8 In-house 3-197 (198) alignment 
Range on Protein: 307-503
Range on HMM: 3-197/198.0
EKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGIN-ETGEYGDISVQNATECINPHYIYREFIIH-RIEDPSNQREVFHYHFK
...|||||  |  |. |||.|.|.  |  |||  ..        . |||  .  ||.|| .||   | . .| |    .|.      |   ||. || | 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHGVPQDPgTVLSFLqdINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYR
.| ..  |.     . |.  . |..       .   |.||||| | | || |. .|| .    ..   . ||.    . .|  | |.. . |.|.|.|.
swkekttpnva.lfvgfv..vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsh.eesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 307-503 9.6e-28 91.7 In-house 4-198 (199) alignment 
Range on Protein: 307-503
Range on HMM: 4-198/199.0
EKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGIN-ETGEYGDISVQNATECINPHYIYREFIIH-RIEDPSNQREVFHYHFK
...|||||  |  |. |||.|.|.  |  |||  ..        . |||  .  ||.|| .||   | . .| |    .|.      |   ||. || | 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHGVPQDPgTVLSFLqdINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYR
.| ..  |.     . |.  . |..       .   |.||||| | | || |. .|| .    ..   . ||.    . .|  | |.. . |.|.|.|.
swkekttpnva.lfvgfv..vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsh.eesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 260-512 1.5e-27 91.1 In-house 41-279 (312) alignment 
Range on Protein: 260-512
Range on HMM: 41-279/312.0
VENKTKNRYKNILPFDHTRVVLHGGDpSIvgsdYINANYISgeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINE
.  |  ||| ||  .|  |  | | .  .    || ||..   .    .....||| |  |.  ||..    .|  |.. .  || | .|||.|   |  
lkfkdlnrypniqcwdrgrftlagde.nf....yihanfvk..ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg

TGEYGDISVQN--ATEcINPHYIYREFIIHRIE-----DPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDInsKQDElvttgnepGPLIVHCSAGIGR
  .  |  |     || |.     .. | ||.         ..  . || . .|||||.|.   | | .|  .  |.|          |.| |||||.||
fvdledhrvyteycte.ieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav..kkdk........kpviahcsagvgr

TGTFIVIDILLNVMMQQgfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQ
|||...|. ..  . .       ... .  |.| .|.  |..  || .. |..|  . ..
tgtlaliesmiaalrhp...rkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
0048179 (Phosphotyrosine protein) phosphatases II 388-503 2.3e-27 90.9 In-house 39-139 (144) alignment 
Range on Protein: 388-503
Range on HMM: 39-139/144.0
RIEDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDelvttgnEPGPLIVHCSAGIGRTGTFIVIDILLnvmmqqgfEADVDIQRAIQLVRAQ
  | ..  ||...|..  |||||||...  .|.||. |.. ..       |.|| .||||||.|||||........        . ..... |..|||..
eyepefleregiqylhlpwpDhgvpdllellleflefieeale.......eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrsr

RSGMVQTEQQYKFVYR
|.|.|....|..|...
rpgavpnpgqlrfLle
SH2 SH2 domain 6-81 2e-25 79.3 Pfam-A 1-77 (77) alignment 
Range on Protein: 6-81
Range on HMM: 1-77/77.0
WFHMNLSGMDAEALLLSKGEDGSFLVRPSQNVQGDFALSVRRTKDVTHIRIQNSGDY-YDLYGGETFATLSELIQYY
|.| ..|. .|| |||....||.||||.|.. .||..|||.. ..|.|.|||.. .  | . ..|.| .|.||...|
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
subfamily_eak_pd Subfamily eak 249-513 7.8e-25 81.9 In-house 39-309 (332) alignment 
Range on Protein: 249-513
Range on HMM: 39-309/332.0
RHLFSRKEGARVENKTKNrYKNILPFDHTRVVLHGGDPSIVGsdYINANYIsgEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRN
..| | .|.||.|.  .|   .|.|.|.  | |        |  ||||  .  | .   ..|| |     . .  ||.|. .. |  ||.  ..|| . .
qrllsisetarleavnrn.vvkivpydrylvrltssqlnrlG..yinasla..efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkle

KCARYWPGIN-ETGEYGDISVQNATECINPHYIYREFIIHRIEdpsNQREVFHYHFKAWPDHGVPQ--DPGTVLSFLQDI------NSKQDEL-------
|  .|.|    |  ..| . |.      .  . .| ..... .   .  .|.||..  | .  .|.  |  ..   ....      . |.. |       
ksdkyfpdktreelkfGildverkefvkrniletrllelskGn...ethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkky

VTTGNEPGPlIVHCSAGIGRTGTFIVIDILLNVMmQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
. |     | |. .. |  |.|.|.|||.|.... ..  .    ..  |  |. .|   | ...|. |.|  .| .. ...
ihtppsfap.iiqsarGsaraGvfvvidllirli.dnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
SH2 SH2 domain 112-187 1.7e-24 76.3 Pfam-A 1-77 (77) alignment 
Range on Protein: 112-187
Range on HMM: 1-77/77.0
WYHGGITGKQAETLLMDKGLDGSFLVRASTHSPGNYVLSARVDGEVAHVIIKTQGGE-FNVGGSPSFKTLNELISHY
|||| |....|| ||.... ||.|||| | ..||.|.|| . ||.| |. |...  . . . .. .|..|.||..||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 263-518 2.5e-24 80.9 In-house 20-269 (290) alignment 
Range on Protein: 263-518
Range on HMM: 20-269/290.0
KTKNRYKNILpFDHTRVVLHGGDpSIVGSDYINANYISgeVPgSEKHYIATQGCL-------PTTINDFWKMIWQESSQIIVMTTNEVERGRN----KCA
. ..|... | . .|||||.|   .   .||| ||...  .| .  . |.||  .         ||..|| |. || .. .||. .  |. .|     ||
emdqRlevpL.veatrvvLkgyg.krfnddyiHAnrvt..cp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

RYWPG-INETGEYGDISVQNATECINPHYIYREFIIHRieDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQdelvtTgnepgPLIVHCSAGI
.| |  ..|   .....|.      .   . || ...   |  ..  | |. .| | .  |..|. |.|| .| .. ..     |     | ||||  ||
kYvpesvgeelkfkgltvkCkskekeddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkask.....t.....pvivHcvdGi

GRTGTFIVIDILLNVMMQQgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL-YHIETQRQLSES
 |  ..  |..    ....  . .| .. ... .| ||  ........ ||   |. . ||...| .|.
SrsAalaaiilgyQkiaet..sgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaee
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 260-373 4.1e-23 76.3 In-house 46-170 (349) alignment 
Range on Protein: 260-373
Range on HMM: 46-170/349.0
VENKTKNRYKNILPFDHTRVVLHGG-DPSI------------VGSDYINANYISGEVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERG
||  .|||||.|||..|.||.|. .  .|             .  |||||||..      ||.|||||  ||.|..||.|.|  .  ....  ... | .
velfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels

RNKCARYWPGINETGEygDISVQNATE
 .|| .||   . ..    . .||. .
lekcdiywqelsysni..tvklqnssl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 394-509 4e-22 73.2 In-house 87-194 (440) alignment 
Range on Protein: 394-509
Range on HMM: 87-194/440.0
NQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvtTGNepGPLIVHCSAGIGRTGTFIVIDILLNVMMQqgfEADVDIQRAIQLVRAQRSGMVQ
. | . .||...|||.|||.  | || ..||.|  |..   .||  |||.|||||| ||||  |..| .|    .     ..||   |. .| .|  |||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek...agn..gpllvhcsagagrtgviiavdsilreakr...sdqidifsfinsmrnnrpqmvq

TEQQYKFVYRSILYHI
| .|| ||. ..|  .
tpeqyafvheavlegl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 313-508 2.6e-21 70.9 In-house 39-220 (255) alignment 
Range on Protein: 313-508
Range on HMM: 39-220/255.0
TqgclptTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG-INETGEYGDISVQnATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGV
       |.. |...| |  .. .|| ..  | |..|| .|.|   .|   . |..|  .|. ..   .    |.  . .  . ..| ||..| |...  
l......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvt.ttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PQDPGTVLSFLQdinskqdeLVTTGnepGPLIVHCSAGIGRTGTFIVIDILLNVM---MQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYH
|...  .|  |.        .|.      ...||||.||||. .|......   |   ...   ...|  . .. .| .|.. ..|  |  |    .|  
Pelareilnilk........vvrds...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 394-513 6.2e-21 69.5 In-house 213-348 (350) alignment 
Range on Protein: 394-513
Range on HMM: 213-348/350.0
NQREVFHYHFKAWPDHGVPQDPGTVLSFLQ----DINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLN-----VMMQQGFE-ADV------DI
.  .|.. ..| |.| ..  .|  .|. |.     |..   |.    ..  |..||||||.|||||.. .| ||.      .... ..  ||       |
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

QRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
.  .. .| ||  |||. .|. |.| ..|.. . ..
siivnelrkqrismvqnldqfifiYeallfyfaLrk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 319-501 9.8e-20 65.2 In-house 102-280 (302) alignment 
Range on Protein: 319-501
Range on HMM: 102-280/302.0
TTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWP-GINETGEYGDISVQNA--TECINPHYIYREFIIHRIEDPS------NQREVFHYHFKAWPDH
 |.. .| .| | .  |.|  .. || . .||| |.   .... ..|  .|.     . ..     ..| .. .|          .. |   .| |||||
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPQDPGTVLSFLQDINSKQDElvttgnepgpLIVHCSAGIGRTGTFIVIDILLNVMMQQGFeadVDIQRAIQLVRAQRSGMVQTEQQYKFV
| |... | |  |.  .| . .          ..||||||.|||||.. |   ... ...      |.   .. ||. | | ||.|||  ..
Gapkeaytaldilkfcesykkn..........vlvhcsaGvGrtGtlvaikyGiqlcskkkv...tdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 261-513 1.4e-18 61.4 In-house 50-289 (302) alignment 
Range on Protein: 261-513
Range on HMM: 50-289/302.0
ENKTKNRYKNILPFDHTRVVLHGGDpsivgSDYINANYIsgEVPGSEKHYIATQGCLPTT---INDFWKMIWQESSQIIVMTTNEVERGRnKCARYWPGI
.|  ||. ...   |...| |..        .|.||  .  |||  ..  | .|    ..   ...||.|..||. . .|.   | |  .     ..|  
knlkknqsedvpildsnlvkleaep.....dsyvnaskv..evPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

NE-TGEYGDISVQNATeCINPHYIYREFIIHRI-EDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDInskqDELVTTGNEpgPLIVHCSAGIGRTGT
 .   |||.. | |     . .    ...|  . |. ||   .  |... |... ||.  ...    ...     .. . ..|  ....    |.|| |.
sgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv....fakkikade..ntvivSknGaGRaga

FIVIDILLNVMmQQGfeADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
|..  . .. . |.|  ... |.  .. .|.||. .|.. .|| ..|...|..| .. 
fltlavavekl.qkg..kepnikeivksiRsqRpravdslkQyvslyialllyikkkv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 259-509 1.8e-18 61.2 In-house 44-279 (303) alignment 
Range on Protein: 259-509
Range on HMM: 44-279/303.0
RVENKTKNRYKNILPFDHTRVVLHggDpsivgSDYINANYISGEvpgSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGIN
 |.|  |||. ... .||..| |   |     | || |.|.  .   |.|. | ||  |. |  |||.|| ..  . ...   . |  .      .|  .
fvknmdknrfvdvicldhskvkls..d.....ssyihasyleld...sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq

ETGEYGDISVQNAtEcINPHYIYREFIIHRIE--DPSNQREVFHYHFKAWPDHGVPQDPGTvlSFLQDINSKQDELVTTGNePGPLIVHCSAGIGRTGTF
.  .. . |..   | ..   .   . .. .   . . .  .  .|.||||   .| |      |...|   |  |    .   | .    .| ||.|||
dflkfeersirvg.e.fkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysd.stptvymslsgcgragtf

IVIDILlnVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHI
 ...     .  .  .| .|. . .. ||  |   ||   |. .||  .  |.
alfeta..hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_hpo-7_pd Subfamily hpo-7 317-506 8.4e-18 59.2 In-house 43-224 (263) alignment 
Range on Protein: 317-506
Range on HMM: 43-224/263.0
LPTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPG-INETGEYGDISVQnATECINPHYIYREFIIHRIEDPSNQREVFHYHFKAWPDHGVPQDP
|  ||. |...| |  .. .|| ..  | |..|| .|.|   .|   . ...|  .|. ..   .  . ..  ...  . ..| || .| |...  |...
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc.ttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

GTVLSFLQdINSKQDelvttgnepgPLIVHCSAGIGRTGTFIVIDILLNVM---MQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSIL
  .|  |. .. .            .|.||||.||||.  | |....   |   ...   ...|  . .. .| .|.. ..|  |  |    .|
reilnilk.varnsk..........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL
subfamily_CG42327_pd Subfamily CG42327 425-505 2.1e-16 54.5 In-house 233-311 (319) alignment 
Range on Protein: 425-505
Range on HMM: 233-311/319.0
INSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQgfEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRSI
||..      | .. |||.|||| |.||||. |  || .. . .   .  ||| . .. || .|.  |.| .||.|.|. .
ingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairslees..krsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 370-513 1.4e-15 51.5 In-house 195-348 (349) alignment 
Range on Protein: 370-513
Range on HMM: 195-348/349.0
NATECINPHYIYREFIIHrieDPSNQREVFHYHFKAWPDHGVPQDPgtvLSFLQDINSKQD-------ELVTTGNEPGPLIVHCSAGIGRTGTFIVIDIL
|  .|..|.    . |     . ..  |..   .| |.| ..  .|    |.|| .. |.|       .|    ..  .|.|||||| ||||... .|.|
nkknCdlpddddddaill...avekPyellqlqvknwldlslllnP...isilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldll

LN--VMMQQGFEaDVD--------IQRAIQLVRAQRSGMVQTEQQYKFVYRSILYHIETQR
|.   ..|. .   ..        |. ..  .| ||  |||  .|. ..| ..| ..  ..
lsileplqnesn.kiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalkk
0038934 (Phosphotyrosine protein) phosphatases II 396-504 8.7e-14 47.1 In-house 77-172 (194) alignment 
Range on Protein: 396-504
Range on HMM: 77-172/194.0
REVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDElvttgNEPGPLIVHCSAGIGRTGTFIVIDIllnvMMQQGFeadvDIQRAIQLVRAQRSGMVQTE
.  ..|.   .||.|.. .  ..|.||. .. . .|     ...|   ||| ||.|||||...  .    .. .|.    . . ||.|.|  | |.... 
kagieylklpfpddgtvPsleillrfldlvdeflne.....dpggvvaVHCkaGlgRtGtlvaaYL....iyrlgm....saeeAialfrekRpgaipnq

QQYKFVYRS
.... ... 
dyleallkr
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 443-504 8e-11 36.2 In-house 2-60 (69) alignment 
Range on Protein: 443-504
Range on HMM: 2-60/69.0
IVHCSAGIGRTGTFIVIDIllnVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRS
.||||.| ||||||| | .    | .   |  |||   .| .|  |  ||  |..| |.. .
vvhcssgtgrtgtfiaimv...emarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_PTPDC1_pd Subfamily PTPDC1 394-507 9.3e-11 36.5 In-house 79-174 (182) alignment 
Range on Protein: 394-507
Range on HMM: 79-174/182.0
NQREVFHYHFkAWPDHGVPQdPGTVLSFLQdinskqdeLVTTGNEPGPLIVHCSAGIGRTGTFIVIDILlnvmmqqgFEADVDIQRAIQLVRAQRSGMVQ
 ......| | .|.|.||.    ..|   .        .|.   . | . ||| || ||||  |   ..        .  ... ..||.|||..|.  .|
meqgiyvynf.gwkDygvas.leriLdivk........vvafalqegkvavhChaGlGrtGvliacylv........yakrltaekaiklvrskrpksiq

TEQQYKFVYRSILY
| .| ..|    |.
treqvelvkefalf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 238-302 1.1e-10 35.6 In-house 17-77 (244) alignment 
Range on Protein: 238-302
Range on HMM: 17-77/244.0
EEFEQLQQQeCRHlFSRKEGARVENKTKNRYKNILPFDHTRVVLHGGDpsIVGSDYINANYISGE
|||  | .. .|. | . .     | ||||| ||||||.|||.|        |||||||||| | 
eefvglsdh.tre.flqtnavlsanatknryinilpfdetrvilsssk..kegsdyinanyiqgs
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 443-504 1.1e-10 35.7 In-house 1-59 (69) alignment 
Range on Protein: 443-504
Range on HMM: 1-59/69.0
IVHCSAGIGRTGTFIVIDIllnVMMQQGFEADVDIQRAIQLVRAQRSGMVQTEQQYKFVYRS
.||||.| ||||||| | .    | .   |  |||   .| .|  |  ||  | .| |.. .
vvhcssGtGrtGtfiaimv...emarikseklvdifnnvqymrkcrpmmvmneneymfihda
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 262-337 3.8e-10 33.8 In-house 37-115 (347) alignment 
Range on Protein: 262-337
Range on HMM: 37-115/347.0
NKTKNRYKNILPFDHTRVVLHGGDPSIVGS----DYINANYISgeVPGSEKHYIATQGCLPTTINDFWKMIWQE-SSQIIV
. .||| |.    | |||||   .     .     |||| .|      ..|.|| ||  || |. |||||.     .|.. 
slsknrskdvklidatrvvlspeksknsraddvetyinashik..fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
PTEN_1 394-502 1.3e-09 33.2 In-house 91-186 (196) alignment 
Range on Protein: 394-502
Range on HMM: 91-186/196.0
NQREVFHYHFKaWPDHGVPQdpgtvLSFLQDINSKQDELVTTGNEPGPLIVHCSAGIGRTGTfividILLNVMMQQGFeadVDIQRAIQLVRAQR-SGMV
... | ..||  ..|||.|      ||.|.||  . .| .   .. .  .||| ||.||.||     ..   .|. |     . . |..|||..|  |..
fksgveylhfp.ieDhgaps.....lselfdicksfiewllsdpngnvVlVHCkaGlgRsGt.....vvaayLmykgk...ltadeAlelvrekRppgap

QTEQQYKFVY
.. .| ....
nspsqerlle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 260-302 2e-08 28.0 In-house 45-86 (440) alignment 
Range on Protein: 260-302
Range on HMM: 45-86/440.0
VENKTKNRYKNILPFDHTRVVLHGGDpSIVGSDYINANYISGE
 .|| ||||.||| .||.||.|.    ..  |||||| ||.| 
pnnkvknryrnilaydhsrvmleevk.gvpdsdyinasyingi
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 257-315 8e-08 26.4 In-house 43-95 (95) alignment 
Range on Protein: 257-315
Range on HMM: 43-95/95.0
GARVENKTKNRYKNILPFDHTRVVLHGGdpsiVGSDYINANYISGEVpgSEKHYIATQG
|.   |  |||. ||.|.| |||||         |||||| .. |      . |||.||
gsseanipknrflnifpydatrvvlttk....rdsdyinacfvdgya..rkncyiaaqg
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 261-418 1e-07 25.0 In-house 26-161 (169) alignment 
Range on Protein: 261-418
Range on HMM: 26-161/169.0
ENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINAnyisgevpgsekhyiatqgclpttindfwKMIWQESSQIIVMTTNEVERGR----NKCARYWPG
 |.||||    |   |||| |.      .|||||||                             .|||.  . .||.  .  ..       .  .  | 
cnetknrpagplapshtrvklqrvmed.lgsdyina.............................rmiwetnasvivvlgdtddknnfwpekedyqlhpa

INeTGEYGDISVQNATECINPH------YIYREFIIHRIEDPSN-QREVFHYhfKAWPDHGVPQDPGTV
.   ||.   |.   |. ...        .   ..||. .|    . ...||   .||. |||| |  |
vi.lgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhy..stwpqngvpqspvhv
subfamily_CDC14_pd Subfamily CDC14 437-498 1.7e-07 25.4 In-house 261-314 (328) alignment 
Range on Protein: 437-498
Range on HMM: 261-314/328.0
NEPGPLIVHCSAGIGRTGTFIVIdillNVMMQQGFEAdvdiQRAIQLVRAQRSGMVQTEQQY
.  | ..||| ||.|||||.|       .| . .| |    . ||  .|  | |.| . || 
kaeGaiavhCkaGLGrtGtLiac....ylmkhyrfta....aeaiawlricrPGsvigpqqk
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 261-418 3.3e-07 23.3 In-house 25-160 (169) alignment 
Range on Protein: 261-418
Range on HMM: 25-160/169.0
ENKTKNRYKNILPFDHTRVVLHGGDPSiVGSDYINAnyisgevpgsekhyiatqgclpttindfwKMIWQESSQIIVMTTNEVERGR----NKCARYWPG
 |.||||    |   |||| |.      .|||||||                             .|||.  . .||.  .  ..       .  .  | 
cnetknrpagplapshtrvklqrvmed.lgsdyina.............................rmiwetnasvivvlGdtddknnfwpekedyqlhpa

INeTGEYGDISVQNATECINPHYI------YREFIIHRIEDPSNQrEVFHYHFKAWPDHGVPQDPGTV
.   ||.   |.   |. ..|            ..||. .|   . ..  .|. .||. |||| |  |
vi.lGewytdslyvrtdkvhpntsgveglfevslvihsydddvte.qlsllhystwpqngvpqspvhv
0048567 (Phosphotyrosine protein) phosphatases II 392-500 3.4e-07 24.8 In-house 24-130 (157) alignment 
Range on Protein: 392-500
Range on HMM: 24-130/157.0
PSNQREVFH-------YHFKAWPDHGvPQDPGTVLSFLQDINSKQDelvTTGNEPGPLIVHCSAGI---GRTGTFIVidilLNVMMQQGFEAdvdiQRAI
|..  ....       ...  . |.| | . ... .| . .|.. .    . .......|||.||    |||.|.|     .  .. .|| .    . ||
pkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflk...ilelagkaiavhckaglkkrgrtatLig....cYlilhlgftp....eeai

QLVRAQRSGMVQTEQQYKF
...|  | |.|   ... .
aplrivrpgsvpfrdasyl
PTPc_motif_SM00404 412-495 9.5e-07 23.8 In-house 53-128 (140) alignment 
Range on Protein: 412-495
Range on HMM: 53-128/140.0
PQDPGTVLSFLQDINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIdillNVMMQQGfeadVDIQRAIQLVRAQRSGMVQTE
|.|  ..  .......  | . .  .. |  .||| ||. |..|.|.      .|....    .... |...|. .|. . ...
plddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia....Ylmryrq....lslaeayefvkerRpiispnl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 401-514 1.3e-06 22.2 In-house 232-343 (347) alignment 
Range on Protein: 401-514
Range on HMM: 232-343/347.0
YHFKAWPDHGVPQDPGTVLSFLQD-INSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQqGFEADVDiqRAIQLVRAQRSGMVQTEQQYK
|   .|| .  |.|   ||....  ..     |..  .   |..| |  |. |. | ..  |... ... |   |.|    .. .| ||.|.      | 
yncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvld.gktpdcd..dlfkkmrdqragvftmsifyt

FVYRSILYHIETQRQ
.  |. |...  . |
yairaalfylklklq
DSPc Dual specificity phosphatase, catalytic domain 410-497 1.4e-06 23.2 Pfam-A 44-123 (133) alignment 
Range on Protein: 410-497
Range on HMM: 44-123/133.0
GVPQDPGTVLSFLQDINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDIllnvMMQQGFeadvDIQRAIQLVRAQRSGMVQTEQQ
..|..  |   . .....  . . .  .. .  .||| ||| |..|.|.  .    |.....    ... |...|. .|| .......
ripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl....mktknl....slneAyefvkerrskispnagf
DSPc Dual specificity phosphatase, catalytic domain 410-497 1.4e-06 23.2 In-house 44-123 (133) alignment 
Range on Protein: 410-497
Range on HMM: 44-123/133.0
GVPQDPGTVLSFLQDINSKQDELVTTGNEPGPLIVHCSAGIGRTGTFIVIDIllnvMMQQGFeadvDIQRAIQLVRAQRSGMVQTEQQ
..|..  |   . .....  . . .  .. .  .||| ||| |..|.|.  .    |.....    ... |...|. .|| .......
ripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl....mktknl....slneAyefvkerrskispnagf
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 272-363 3e-06 21.6 In-house 3-78 (130) alignment 
Range on Protein: 272-363
Range on HMM: 3-78/130.0
LPFDHTRVVlhggdpsivGSDYINANYISgeVPGSEKHYIATQGCLPTTINDFWKMIWQESSQIIVMTTnEVERGrnkcARYWPGINETGEY
|.|. .|.          | .||||...   . |  . |. ||  |  |  |||||. .    ..|.    ||        |||  .    |
lefevsrlq.........gntyinasfvG..llgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg.sveee....deywpdsePlewy
subfamily_DSP23_pd Subfamily DSP23 442-503 8.2e-06 20.5 In-house 87-140 (148) alignment 
Range on Protein: 442-503
Range on HMM: 87-140/148.0
LIVHCSAGIGRTGTFIVIDIllnvMMQQGFEAdvdiQRAIQLVRAQRSGMVQTEQQYKFVYR
. |||  | |||||..   .    . .... |      ||  || .| | |.| .| | |. 
vsvhcllgrgrtgtmlacyl....vkerklaa....aeaiaevrrlrpgsvetveqeklvrd