Gene PTPN6-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP058_AA protein Get Run
AqueP058_AA_103-225 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 95-224 9.4e-45 147.9 In-house 2-134 (306) alignment 
Range on Protein: 95-224
Range on HMM: 2-134/306.0
VHLLSPVLHNNEGHLPRDGEVKDHLNLEQDFEEL----PSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTASTGGLqAQY
..||.  ..... .| ...| ... ..|..||||     ..|.|...|.|..| .||||....|||.....||||||.||.||||. ||....|   ..|
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd.ksy

IATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
||||| |.||.|||||.||||.| .|.|.|. ||
iatqgclettvsdFWrmvwqensrvivmttkevE
0050432 (Phosphotyrosine protein) phosphatases II 85-224 7.6e-29 96.4 In-house 11-144 (308) alignment 
Range on Protein: 85-224
Range on HMM: 11-144/308.0
APLRLKDETLVHLLSPVLHNNEGHLPRdgeVKDHLNLEQDFEELPSYLYSQD--KGNKIQNIHKNRYNASIPFDDNVISLkepSvYGSTYINASPIKTAS
..|  ....||. |   ...   .| .    .|  .||. ||||.|.  . .   ... .|..||||   .|.| . . |   .  ||.||||| ... |
lllfrdtsilvsslklsvldllkllek...aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...d.egsdYInAsyvdgys

tGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  .|. ..|||||||..|. ||||.||......|.|||.|||
.sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklve
0046845 (Phosphotyrosine protein) phosphatases II 120-224 4.6e-28 93.8 In-house 1-113 (284) alignment 
Range on Protein: 120-224
Range on HMM: 1-113/284.0
NLEQDFEELPSYLY----SQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV--YGSTYINASPIKTA--STGGLQAQYIATQGPLDTTISDFWRLVWQE
.||..||||.|. .    | . ... .|..||||   .|.|.. . || ..    .|.||||| ...   .    . ..|||||||..|. ||||.||..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

QSSIIIMLTELVE
....|.|||||||
nvrvIVmltelve
0051299 (Phosphotyrosine protein) phosphatases II 116-224 4.8e-28 93.9 In-house 20-128 (288) alignment 
Range on Protein: 116-224
Range on HMM: 20-128/288.0
KDHLNLEQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQ
..  .|.. ||||.|.|  ...  ... .|..||||   .|.|.. . |.  ..| ||.||||| |   ..  |. ..|||||||..|..||||.||...
ngltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi...dgynlkrkfIatqgPlpntvedFWrmvweqn

SSIIIMLTELVE
...|.|||.|||
vrvIvmltklve
DSPc_SM00195 122-224 7.3e-28 93.0 In-house 3-105 (263) alignment 
Range on Protein: 122-224
Range on HMM: 3-105/263.0
EQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIM
...||.| ..    . ....| .| .||||.  .|.|.. . ||..    ||.||||. ||.|     . .||||||||..|..||||.||.|...||.|
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTELVE
||| .|
lteeee
PTPc_SM00194 122-224 7.3e-28 93.0 In-house 3-105 (263) alignment 
Range on Protein: 122-224
Range on HMM: 3-105/263.0
EQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIM
...||.| ..    . ....| .| .||||.  .|.|.. . ||..    ||.||||. ||.|     . .||||||||..|..||||.||.|...||.|
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTELVE
||| .|
lteeee
subfamily_PTPRD_pd Subfamily PTPRD 116-224 2.1e-27 91.0 In-house 20-127 (564) alignment 
Range on Protein: 116-224
Range on HMM: 20-127/564.0
KDHLNLEQDFEELPSYL-YSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQS
...|..|...... .    . .. || .| .||||.  ...| . . | | . . || ||||| |..  .   . .|||||||| .||.||||.||...|
nsdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrk...rkayIAtqgPlaetiedFWRmvweqns

SIIIMLTELVE
|.|.|||.|.|
stiVmltkleE
0036941 (Phosphotyrosine protein) phosphatases II 122-224 3.5e-27 90.9 In-house 16-114 (297) alignment 
Range on Protein: 122-224
Range on HMM: 16-114/297.0
EQDFEELPSYLY--SQDKGNKIQNIHKNRYNASIPFDDNVISLkepSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIML
.. ||||...|.  | . ... .|..||||   .|.|.. . |   .  || ||||| .   .. .|. ..|||||||..|. ||||.||......|.||
lkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv...dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

TELVE
|||||
telve
0039614 (Phosphotyrosine protein) phosphatases II 116-225 6.6e-27 90.2 In-house 29-138 (297) alignment 
Range on Protein: 116-225
Range on HMM: 29-138/297.0
KDHLNLEQDFEELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISL--KEPSVYGSTYINASPIktaSTGGL-QAQYIATQGPLDTTISDFWRLVWQEQ
..   |...||||.|.  ..  .....|..||||   .|.|.. . |  .. .. .|.||||| .   ..  | . ..|||||||. |. ||||.||...
nsktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv...dgydlltrkfIatqgPlpetvedFwrmvweqg

SSIIIMLTELVEL
...|.|||.||||
vtvivmLtklvel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 119-224 7.7e-27 89.1 In-house 21-126 (288) alignment 
Range on Protein: 119-224
Range on HMM: 21-126/288.0
LNLEQDFEELPSY--LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSI
 ....... |..     |...|.. .| .||||.  .|.| . . ||. . . |. ||||| |.       . .||||||||  |. |||.||.....| 
tgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk...kkkyiatqgPladtvndfWelvyenktst

IIMLTELVE
|.|||||||
ivmltelve
0047943 (Phosphotyrosine protein) phosphatases II 118-225 1.8e-26 88.6 In-house 11-114 (273) alignment 
Range on Protein: 118-225
Range on HMM: 11-114/273.0
HLNLEQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLkepSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSI
   |.. ||.|.|.   ..   .....|..||||   .|.|.. . |   .  || ||||| .   ..  |. ..|||||||. |. ||||.||......
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyv...dgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IIMLTELVEL
|.||||||||
iVmLtelvel
0045450 (Phosphotyrosine protein) phosphatases II 120-225 1.5e-25 86.0 In-house 28-144 (307) alignment 
Range on Protein: 120-225
Range on HMM: 28-144/307.0
NLEQDFEELPSYLY----SQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV--YGSTYINASPIKTA-----STGGLQAQYIATQGPLDTTISDFWRLV
 |.. ||.|.|.      . . ... .|..||||   .|.|.. . |. ..    .| ||||| ...      ..  |. ..|||||||. |. ||||..
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrml

WQEQSSIIIMLTELVEL
|......|.||||||||
weqgvtvivmltelvel
0040438 (Phosphotyrosine protein) phosphatases II 117-225 1.9e-25 85.3 In-house 16-123 (317) alignment 
Range on Protein: 117-225
Range on HMM: 16-123/317.0
DHLNLEQDFEELPSYLY-SQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSS
|.  |.. ||.|.|. . . . ... .|..||||   .|.|.. . |.  .....|.||||| .   ..  |. ..|||||||. |. ||||.||.....
dftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv...dgpnlkrkfIatqgPlpntvedFwrmvweqgvt

IIIMLTELVEL
.|.|||||.||
vivmLteleel
0043336 (Phosphotyrosine protein) phosphatases II 124-225 1e-24 82.9 In-house 25-125 (278) alignment 
Range on Protein: 124-225
Range on HMM: 25-125/278.0
DFEELPSY-LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTE
.||||.|. |.... .....|..||||   .|.| . . |.  .....|.||||| .   ..   . ..|||||||. |. ||||.||......|.||||
efeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv...dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLte

LVEL
||||
lvel
subfamily_PTPN12_pd Subfamily PTPN12 132-225 1.8e-24 81.1 In-house 29-120 (290) alignment 
Range on Protein: 132-225
Range on HMM: 29-120/290.0
LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVEL
 ||...|.| .|..||||   .|.| . . |..  .. || ||||. || ..    . .|||.|||| .|..||||..|. . .|..|. ..|||
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg...kleyiaaqgPLpktlddfWrmiweknveivvmaCrevel
Y_phosphatase Protein-tyrosine phosphatase 143-224 2.9e-24 81.1 Pfam-A 1-78 (235) alignment 
Range on Protein: 143-224
Range on HMM: 1-78/235.0
NIHKNRYNASIPFDDNVISLkEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
| .||||.  .|.|.. . | . |   | ||||. .|. ..   . ..|||||||. ||.||||.||||....|.|||.|.|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltslee
Y_phosphatase Protein-tyrosine phosphatase 143-224 2.9e-24 81.1 In-house 1-78 (235) alignment 
Range on Protein: 143-224
Range on HMM: 1-78/235.0
NIHKNRYNASIPFDDNVISLkEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
| .||||.  .|.|.. . | . |   | ||||. .|. ..   . ..|||||||. ||.||||.||||....|.|||.|.|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltslee
subfamily_Ptp69D_pd Subfamily Ptp69D 119-224 6.9e-24 79.5 In-house 22-127 (307) alignment 
Range on Protein: 119-224
Range on HMM: 22-127/307.0
LNLEQDFEELP--SYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSI
  |....|.|.      |   ..|  |  ||||.. ..||.. . ||. .    |.||||| ||.      . ..|| |.|...|| ||||.... .. .
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyke...kkkfiaaqdPveatigDfWRmiaeqevtl

IIMLTELVE
|.||..| |
ivmlsnlte
subfamily_PTPRB_pd Subfamily PTPRB 115-224 9.3e-24 79.0 In-house 21-130 (293) alignment 
Range on Protein: 115-224
Range on HMM: 21-130/293.0
VKDHLNLEQDFEELPSYLY--SQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQE
 ...|.. ...||| .     .... .. .|  ||||.  .|.| . . |..  .  || ||||. |.  ..   . ..||||||| .|. ||||.||..
adsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyns...prefiatqGPlpetvddfWrmvwek

QSSIIIMLTELVE
.||||.|||.|||
kssiivmltqlve
0045098 (Phosphotyrosine protein) phosphatases II 122-225 1.1e-23 79.4 In-house 12-101 (278) alignment 
Range on Protein: 122-225
Range on HMM: 12-101/278.0
EQDFEELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISlkepsvygsTYINASPIKTAstgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTE
| .|  |... ..   .... |..||||   .|.| . .           ||||| |..      . ..|||||||..|..||||..|......|.||||
efefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy.....pkkfIatqgPlpstvadfwrmlwelgitvivmlte

LVEL
||||
lvel
subfamily_PTPN3_pd Subfamily PTPN3 137-224 1.2e-23 78.4 In-house 35-120 (280) alignment 
Range on Protein: 137-224
Range on HMM: 35-120/280.0
KGNKIQNIHKNRYNASIPFDDNVISLKEPSVygsTYINASPIKTASTG-GLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. .| .|..||||   .|.|.  ..||| ..    ||||. ..  . . ||  .||||||||..| .|||..||...||.|.|||.|||
aarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlve
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 118-224 1.3e-23 78.5 In-house 19-125 (318) alignment 
Range on Protein: 118-224
Range on HMM: 19-125/318.0
HLNLEQDFEEL--PSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSS
.|.|....|.|   .   .. | ..  | .||||.  ...|.  . |..  .. || ||||. |        . .|||.|.||  ||.||||.||. .|.
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrr...kkayiaaqaPlpetieDfWrmvWeqnsa

IIIMLTELVE
.|.|||...|
vivmltqeee
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 118-224 1.8e-23 78.0 In-house 4-109 (274) alignment 
Range on Protein: 118-224
Range on HMM: 4-109/274.0
HLNLEQDFEELPSYLySQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY--GSTYINASPIKTAStgGLQAQYIATQGPLDTTISDFWRLVWQEQSSI
  .||..| |||.   .|.. .   . .||||.. .| .   ..|.. |.    |.||||  ||  .  . .  |.|||||| .|..||||...||....
fkdlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGyd..eeskayvatqGPlpntvadfWrmiyqeevqv

IIMLTELVE
|.|||.| |
ivmltklke
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 120-224 2.3e-23 77.8 In-house 24-127 (319) alignment 
Range on Protein: 120-224
Range on HMM: 24-127/319.0
NLEQDFEELPSY-LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIII
 ||..|..|      . |. .| .| .||||.  ...|   . |.| . | ||.||||| | .      . ..||||.||..||.||||.||.|.|||..
llekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqe...rekfiatqaPlentiedfWrmvWeeessivv

MLTELVE
|||.|||
mltklve
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 134-224 5.1e-23 76.7 In-house 47-135 (298) alignment 
Range on Protein: 134-224
Range on HMM: 47-135/298.0
SQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTGGlqaQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
... ..| .| .||||   |..|   . |..  .   |.||||| .....       .||||.|| .|..||||.|..|... |.|||.|.|
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn...afiatqaPltetvedFWrmvteedigtiVmltnlee
0040439 (Phosphotyrosine protein) phosphatases II 137-225 1.1e-22 76.3 In-house 5-91 (249) alignment 
Range on Protein: 137-225
Range on HMM: 5-91/249.0
KGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVEL
 ...  |..||||   .|.| . . |.  |....| ||||| |   ..   . ..|||||||. |..||||..|......|.|||.||||
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi...dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel
subfamily_PTPRN_pd Subfamily PTPRN 116-224 2.8e-22 73.8 In-house 26-136 (297) alignment 
Range on Protein: 116-224
Range on HMM: 26-136/297.0
KDHLNLEQDFEELPSYLY---SQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTAStgGLQAQYIATQGPLDTTISDFWRLVWQE
|.. .||...| | .|     ... ... .|..|||..| .|.|.. ..|||  |   | |||||.|        .. |||||||| .|..|||..||..
knkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd..prapayiatqgplastvadfwqmvweq

QSSIIIMLTELVE
 . .|..||.| |
Gvvvivnltrlee
subfamily_PTPN14_pd Subfamily PTPN14 138-224 3e-22 74.0 In-house 44-129 (300) alignment 
Range on Protein: 138-224
Range on HMM: 44-129/300.0
GNKIQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
..  .| .|||..  .|..|| . |.      . ||||| ||. | || . .||..||||..|. |||..||... ..|.||||  |
aklpenaeknrfkdvlPyednrvelsptkenstgyinassikv.svggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeee
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 127-220 3.8e-22 74.0 In-house 45-136 (319) alignment 
Range on Protein: 127-220
Range on HMM: 45-136/319.0
ELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
.|.  |  |.  |  ||  |||.   ..|| ||. |.    . .| ||||| ..       . .|||.||||| |. ||||..|. ..| |..||
klgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqr...kdkyiaaqGPldntladfWrmiweyncstivllt
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 133-220 7.4e-22 73.1 In-house 15-100 (284) alignment 
Range on Protein: 133-220
Range on HMM: 15-100/284.0
YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
  |   |  ||  |||.   ..|| ||. |.    . .| ||||| |.       . .||||||||| |. ||||..|. ..| |..||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqr...kdkyiatqGPldntladfWrmiweyncstivllt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 121-224 1.8e-21 71.4 In-house 26-128 (315) alignment 
Range on Protein: 121-224
Range on HMM: 26-128/315.0
LEQDFEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISL--KEpSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIII
..||.| .|   |.  |  .||.| .||||   |..|   . |   |    .| |.||. |.  .    . .|||.|||. ... ||||||..|. . |.
fkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlplle.ndphsdyvnanfidGynk...krryiaaqgpnvasvkdfwrlvfeedigkiv

MLTELVE
|||.|||
mltnlve
subfamily_PTPRA_pd Subfamily PTPRA 116-224 2e-21 71.2 In-house 29-137 (330) alignment 
Range on Protein: 116-224
Range on HMM: 29-137/330.0
KDHLNLEQDFEELPS--YLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQ
 |   . ..|. ||.     . .  .| .| .|||.   .|.| . . | .   |  | ||||| |.       . ..||.|||.. |. ||||..|. .
ddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyke...kdkfiaaqGPkeetvedfwrmiweqk

SSIIIMLTELVE
|. |.||||| |
sativmltelke
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 121-223 2.6e-21 70.8 In-house 21-122 (315) alignment 
Range on Protein: 121-223
Range on HMM: 21-122/315.0
LEQDFEELPSY-LYSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIM
. ..| .||    | |  . . .| .||||.  .|.| . . |        | ||||| ||.  .   .  |||.||||.....||||.|.||. . |.|
fseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd...dkayiasqgPlkasvddfwrmvlqekvttivm

LTELV
.|.. 
vtkkq
0042113 (Phosphotyrosine protein) phosphatases II 138-225 3.9e-21 71.0 In-house 4-89 (245) alignment 
Range on Protein: 138-225
Range on HMM: 4-89/245.0
GNKIQNIHKNRYNASIPFDDNVISLKEPSVY-GSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVEL
.... |..||||   .|.|.. . |....   .|.|||||..   ..     ..|||||||. |. ||||..|......|.||||..||
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv...dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeel
subfamily_PTPRG_pd Subfamily PTPRG 119-224 4.1e-21 69.8 In-house 19-127 (563) alignment 
Range on Protein: 119-224
Range on HMM: 19-127/563.0
LNLEQDFEELPSYLYSQ----DKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYGS--TYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQ
  ....||.| |   |.    .. .| .| .||||   ...|   ..|.. .   .   ||||. |.       . ..||||||| .|. ||||..|...
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqk...skafiatqgplkdtfddFWrmiWeqn

SSIIIMLTELVE
..||.|.|.|||
vaiivmitnlve
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 114-224 4.2e-21 70.4 In-house 17-125 (305) alignment 
Range on Protein: 114-224
Range on HMM: 17-125/305.0
EVKDHLNLEQDFEELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYG-STYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQ
.|..  .||.....|..   | | |.| .| .|||... ...||. | |.| .  . | ||||| ... .    . .||..||||..|..|||||...|.
rvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykr...kkkyivaqgPlkntvadfWrliveek

SSIIIMLTELVE
 | |.|||.|||
vstivmltklve
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 138-224 5.8e-21 69.8 In-house 4-88 (250) alignment 
Range on Protein: 138-224
Range on HMM: 4-88/250.0
GNKIQNIHKNRYNASIPFDDNVISLKEPS-VYGSTYINASPIKTASTGglqAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
..| || .||||   |..|   . |.. .    | ||||| ... .       .||||||| .|| ||||.|..|.|. |.|||.|.|
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder...kafiatqgPlqatiedfWrmvleeksgtivmLtnLke
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 139-224 1.8e-20 68.0 In-house 29-111 (283) alignment 
Range on Protein: 139-224
Range on HMM: 29-111/283.0
NKIQNIHKNRYNASIPFDDNVISLKEPSVygsTYINASPIKTASTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
   .| .|||..  .| | ... ||  |    .||||. |  .     . .||..|.||| |. |||..|..|. . |.|||.| |
sadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 122-223 2.1e-20 67.3 In-house 21-121 (515) alignment 
Range on Protein: 122-223
Range on HMM: 21-121/515.0
EQDFEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIML
 ..| .||   .| |   ..  | .||||.  .|.| . . |        | |.||| |..  .   .  |||.|||......||||||.||. . |.|.
seefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn...dkayiasqgPnkasvddfWrlvlqenvttiamv

TELV
|.| 
tklk
0037934 (Phosphotyrosine protein) phosphatases II 139-225 2.3e-20 68.7 In-house 6-85 (243) alignment 
Range on Protein: 139-225
Range on HMM: 6-85/243.0
NKIQNIHKNRYNASIPFDDNVISLkepsvYGSTYINASPIKTAStgglqaQYIATQGPLDTTISD----FWRLVWQEQSSIIIMLTELVEL
....|..||||   .|.|.. . |      || ||||. |.         ..|||||||. |. |    |||..|......|.||||||||
llpenlsknrysdilpydhsrvkl.....egsdyinanliyvtp......rliatqgPlpetveddlasfwrmlwelgitvivmltelvEl
subfamily_PTPRK_pd Subfamily PTPRK 126-224 2.4e-20 67.6 In-house 26-122 (314) alignment 
Range on Protein: 126-224
Range on HMM: 26-122/314.0
EELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY-GSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
||  |..   |  .| .| .|||..  ...|   . |.       | ||||. | .       |..|.|||||. |. ||||||..|... |.|||||||
eeyeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykr...paafivtqgPlqetvkdfWrlvydencasivmltelve
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 137-224 2.4e-20 67.5 In-house 32-116 (287) alignment 
Range on Protein: 137-224
Range on HMM: 32-116/287.0
KGNKIQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. ... ...||||   .|.||. . | . . .|| ||||  . .      . ..||.|||. .|. ||||.|....|. .|..|  ||
aaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytd...deafiaaqgPiaatvrdfwravletrsasvitmtreve
subfamily_PTPN23_pd Subfamily PTPN23 117-224 3.3e-20 67.1 In-house 13-119 (288) alignment 
Range on Protein: 117-224
Range on HMM: 13-119/288.0
DHLNLEQDFEELPSYLYSQDKGNKI----QNIHKNRYNASIPFDDNVISLKepsVYGSTYINASPIKTASTGGlqAQYIATQGPLDTTISDFWRLVWQEQ
.. .|.. |.|| ..   . ... |     . .|||..  .|.| | . |.        ||||| .|  |.|    ..||||.||..|..|||..|....
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgc..PdfiatqaPlqstlnDFWlmvyeqk

SSIIIMLTELVE
||.|.||..  |
ssviVmllskee
subfamily_PTPN13_pd Subfamily PTPN13 134-224 3.5e-20 67.4 In-house 28-113 (273) alignment 
Range on Protein: 134-224
Range on HMM: 28-113/273.0
SQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVygstYINASPIKTAStGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. ..|.| .| .||||   .|.|.  . |.. .     ||||| ||    |  . .|||.|||| .|..|||..||. ....|.|.|  .|
tcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpv.gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtleke
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 122-224 4.9e-20 66.3 In-house 23-124 (392) alignment 
Range on Protein: 122-224
Range on HMM: 23-124/392.0
EQDFEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIML
 ..| .||.  .| |  ..|  |..||||.  .|.| . . |     .  | |.||| |..  .   .  |||.|||  ....||||.|.||. . |.|.
feefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdn...ekayiasqgpnaaslddfwrmvfqenvttiamv

TELVE
|.| |
tklke
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 124-222 5e-20 66.8 In-house 31-126 (297) alignment 
Range on Protein: 124-222
Range on HMM: 31-126/297.0
DFEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY-GSTYINASPIKTASTgglqaQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTE
.|  ||.  ...| . .|  |..|.||. ..|.| . . |.       | |.||| .|.        ..|.|| | ..|. |||..|..|| |.|.||..
eflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.....rlittqmPmkatvadfWamvldeqvstivmlnd

L
.
d
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 133-224 8e-20 65.9 In-house 36-127 (290) alignment 
Range on Protein: 133-224
Range on HMM: 36-127/290.0
YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY---GSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
..   |.  .| ..||..  .. ||| | |.. |        ||||. ||  .    . ||||||||.  |. |||.|.|||...||.|||. .|
htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke...kkqyiatqgpvsntlvdFWkliwqekvtiivmltniie
SH2 SH2 domain 8-82 8.7e-20 61.2 Pfam-A 1-77 (77) alignment 
Range on Protein: 8-82
Range on HMM: 1-77/77.0
WFHPNLSGFEAEELLKR-TVNGRFLFRPSQSNPRDCTLSIKTEGGVTHVRIKKNETG-YHLFPDEVFPNLNSFVHHY
|.| ..|. |||.||.    .| || |.|.|.| | |||....| |.|.||...|.| | .. .| | .|.  |.||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 143-224 5.3e-19 63.4 In-house 3-81 (237) alignment 
Range on Protein: 143-224
Range on HMM: 3-81/237.0
NIHKNRYNASIPFDDNVISLKEPSVyGSTYINASPIKTAstGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|  ||||   . .| . . || .   || ||||. .|     |   .|||.||||...  |||..||||. |.|.||| |.|
nkiknrygnivaydhsrvvlkgags.gsdyinatylkgf..dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltglie
subfamily_PTPN1_pd Subfamily PTPN1 133-224 7.5e-19 62.5 In-house 22-107 (290) alignment 
Range on Protein: 133-224
Range on HMM: 22-107/290.0
YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVygsTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
... . .. .|  .|||    |.|   | |.. ..    ||||| ..      .. .|| |||||  |.. ||..||...|  ..|| ..||
fptreaklpenrnlnryrdvspydhsrikleradn...dyinaslvelee...akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve
subfamily_ptpA1_pd Subfamily ptpA1 136-220 3.4e-17 57.3 In-house 40-121 (418) alignment 
Range on Protein: 136-220
Range on HMM: 40-121/418.0
DKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTAstggLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
 .|.| .|  ||||   .| .   . ||.     || ||||  |  |       |.|.|||||  ||.||||.||...  ||.||.
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga....ypkqfictqgplpntiadfwrmvwenrcriivmls
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 121-224 3.8e-17 56.9 In-house 17-121 (301) alignment 
Range on Protein: 121-224
Range on HMM: 17-121/301.0
LEQDFEELPSYLYS-QDKGNKIQNIHKNRYNASIPFDDNVISLKEPS---VYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSII
.|....|| ..     . | . .| . ||..   ..||| | ||. .   .   .||||| |.  |    . ..||.|||.. |. |||||.|||. . |
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgyse...kkkfiaaqgpmkktlvdfWrliwqekpvsi

IMLTELVE
.|.|.| |
vmvtnlke
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 139-224 4.6e-17 56.9 In-house 16-100 (270) alignment 
Range on Protein: 139-224
Range on HMM: 16-100/270.0
NKIQNIHKNRYNASIPFDDNVISLKEPS-VYGSTYINASPIKtaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. ... . |||.  .|     . |.| .    ..||||  ..     | ...|||..|||.||...|||..|.|... |.|.|.|.|
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvr..GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE
subfamily_PTPN9_pd Subfamily PTPN9 141-224 6.4e-17 56.5 In-house 40-121 (297) alignment 
Range on Protein: 141-224
Range on HMM: 40-121/297.0
IQNIHKNRYNASIPFDDNVISLK-EPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  |..||||.  . .|.  . |. ..    | ||||. .        .  .|||||||. |.|||||.||...  .|.| | .||
ranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykq...kkafiatqGplkktvsdfWrmvWeqevlvivmttrvve
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 140-224 6.8e-17 56.5 In-house 38-120 (281) alignment 
Range on Protein: 140-224
Range on HMM: 38-120/281.0
KIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. .|..||||.  . .|   . . .. .   . ||||. ... .    ...|||||||. ... .||..||... |.|.|.|. .|
adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg...ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreie
0049772 (Phosphotyrosine protein) phosphatases II 136-222 1.8e-16 56.2 In-house 39-151 (314) alignment 
Range on Protein: 136-222
Range on HMM: 39-151/314.0
DKGNKIQNIHKNRYNASIPFDdNVISLKEPSVYGSTYINASPIKTAstgglqAQYIATQGPLDTTISDF----------WRLV--WQEQSSIIIM-----
 ....  |..||||   .|.| |   |.  .|.|| ||||| ...        ..|||||||. |. ||          ||.|  .. .. .| |     
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------LTEL
                |..|
ladelsrLdaAlgKtpllil
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 109-224 2.6e-16 54.3 In-house 16-140 (350) alignment 
Range on Protein: 109-224
Range on HMM: 16-140/350.0
LPRDGEVKDHLNLEQDFEeLPSYLYSqdKGNKIQNIHKNRYNASIPFDDNVISLK---------EPSVYGSTYINASPIKTASTGG-LQA--QYIATQGP
... ..|| .| || | |  ||  .     . ..   ||||.  .|.. . . ||         . |. .. ||||. .| .  .   ..  .|||||.|
itknstvksrlsLesdse.spsnDvi..lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaP

LDTTISDFWRLVWQEQSSIIIMLTELVE
|  |. ||.... . .  .|..||..||
lpstvddfykvillnkvkvilsltsdve
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 142-224 6.7e-16 53.1 In-house 46-122 (287) alignment 
Range on Protein: 142-224
Range on HMM: 46-122/287.0
QNIHKNRYNASIPFDDNVISLKepsVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|| .|||..  .. |.. . ||        ||||. |.. .    . ..|....|.  |. .||.|..... ..|.||... |
qnkdknRltqilvpdnyrvllk...gehpdyinavfidgyke...kkafiiaesPmfntarnfWkliddrnvtaivmlcqeke
subfamily_CG42327_pd Subfamily CG42327 122-224 1.7e-15 51.5 In-house 8-108 (319) alignment 
Range on Protein: 122-224
Range on HMM: 8-108/319.0
EQDFEELPSYLYSQDkGNKIQNIHKNRYNASIPFDD-NVISLKEPSVYGSTYINASPIKTASTGglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
 ..|..||  . . |    .    |.|.  ..|. . .|.. . ..   . |..|| ..       ...|||.| .|. . |||||.||. || .|. ||
aeefrdlPqliarad.evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydda..pnsyiaaqvsledsssdfwrtvweqqsrvivqlt

ELVE
.| |
dlse
subfamily_CG7180_pd Subfamily CG7180 138-222 1.9e-15 51.3 In-house 37-119 (296) alignment 
Range on Protein: 138-222
Range on HMM: 37-119/296.0
GNKIQNIHKNRYNASIPFDDNVISLKEPS-VYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTEL
| . .|. |||.   .|.| | . |..      | ||||. . .      ...|| |..| . |. .|||||..|..| ...||. 
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflk...kkeyivteapkketvdefWrlvydeeisavvvLtkt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 124-222 3.5e-15 51.0 In-house 28-125 (325) alignment 
Range on Protein: 124-222
Range on HMM: 28-125/325.0
DFEELPSYL-YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYG-STYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLV--WQeqSSIIIML
.|. |||    ..    | .|. |||..  ...| . . |.     . | ||||| ...      .  ..|.| || .|| |.||||  |.  .|....|
efgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkk...kdvflaaqaPltatindlWrlvldWr..csvvvvl

TEL
 ||
nel
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 144-224 4.9e-15 49.9 In-house 49-127 (439) alignment 
Range on Protein: 144-224
Range on HMM: 49-127/439.0
IHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTGGLqaqYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  ||||.   .||   . | . | |  | ||||  ||   .  |   ||||||| . |  ||||||...... |.|||.|||
qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddkl...yiatqgpkkettddfwrlviekktvtivmltnlve
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 141-221 5.6e-15 49.7 In-house 50-127 (310) alignment 
Range on Protein: 141-221
Range on HMM: 50-127/310.0
IQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTE
 ...|||||   .  |.  . ||        || |  .||     |.. .| .||||. || ||||...||..  |..|  
kkymhknrysdvvcldtsrvklkidksryedyihanyvktny...lrstficsqgplqhtiidfwrmifqeraesilllck
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 140-224 7.1e-15 49.8 In-house 5-88 (239) alignment 
Range on Protein: 140-224
Range on HMM: 5-88/239.0
KIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|  |  ||||   . .| . . |.. |    | ||||| ..     |    |||||| . ..  ||||..|||.  .|.||| |.|
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdy..dgspkayiatqgcveissgdfwrmmwqerrcvivmltglie
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 140-224 8.1e-15 49.6 In-house 4-87 (239) alignment 
Range on Protein: 140-224
Range on HMM: 4-87/239.0
KIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|  |  ||||   . .| . . |.. |    | ||||| ..     |    |||||| . ..  ||||..|||.  .|.||| |.|
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdy..dgspkayiatqgcveissgdfwrmmwqerrcvivmltglie
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 142-224 9.6e-15 49.2 In-house 32-112 (297) alignment 
Range on Protein: 142-224
Range on HMM: 32-112/297.0
QNIHKNRYNASIPFDDNVISLKEpSVYGSTYINASPIKTAsTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  ..||||.  . .||. . |.  .. .. ||||  .        . .|| .||||..|. |||.||....  .|.|...| |
sslrknryrdilatddtrvkllr.viterdyinadyvvfp.deeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqe
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 121-221 1.3e-13 45.6 In-house 8-105 (267) alignment 
Range on Protein: 121-221
Range on HMM: 8-105/267.0
LEQDFEELPSYLYSQDK---GNKIQNIHKNRYNASIPFDDNVISLKEPSVYgstYINASPIKTASTGglqAQYIATQGPLDTTISDFWRLVWQEQSSIII
.|..||..      . .       .|  .||.. ..|.||... |..       ||||| ...  |.    ..|.||.||. ||.||. .. ... ..|.
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyktk...nafivtqdplkntitdfltvihdqkvpviv

MLTE
.|| 
lltk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 122-224 1.8e-13 44.8 In-house 14-117 (281) alignment 
Range on Protein: 122-224
Range on HMM: 14-117/281.0
EQDFEELPSYLYSQD--KGNKIQNIHKNRYNASIPFDDNVISLKE--PSVYGSTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSSIII
.|.| .||    |.     |.  | .||||     .|   . ||   |    . || |  |..     |.  || ||||   | .||||..|||... |.
kqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf...lkrgyiltqgpkketradfwrmiwqenttaiv

MLTELVE
|| ...|
mlcqfle
0041856 (Phosphotyrosine protein) phosphatases II 143-222 2.7e-13 45.4 In-house 1-68 (182) alignment 
Range on Protein: 143-222
Range on HMM: 1-68/182.0
NIHKNRYNASIPFDDNVislkepsvyGSTYINASPIKTASTGGLqaqYIATQGPLDTTISDFWRLVWQEQSSIIIMLTEL
|..||||   .|.| .          ...||||. .  .  .     .|||||||. |. ||.|...... ..|..||| 
nldknrysdilpydhsr.........dldyInanlylgslpatr...fiatqgpllstvadflrmlkelgittivnltee
subfamily_eak_pd Subfamily eak 115-225 8.3e-13 42.4 In-house 25-130 (332) alignment 
Range on Protein: 115-225
Range on HMM: 25-130/332.0
VKDHLNLEQDFEELPsYLYSQDKGNKIQNIHKNRYNaSIPFDDNVISLKEPSVYGSTYINASPIKTASTGglqAQYIATQGPLDTTISDFWRLVWQEQSS
.....|. .|...    | |. ..........| ..  .|.| . . |         ||||| .. .  |    .|| |  . .. .  ||..| ...| 
inqrinivadlddyq.rllsisetarleavnrnvvk.ivpydrylvrltssqlnrlGyinaslaefsevG...rkyiltGiasedkvfafwqmvleqksp

IIIMLTELVEL
 |..| | |||
aivqlledvel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 140-224 1.5e-12 41.8 In-house 53-130 (290) alignment 
Range on Protein: 140-224
Range on HMM: 53-130/290.0
KIQNIHKNRYNASIPFDDNVISLKEpsVYGSTYINASPIKtastgGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|  ...||||   .  |   . ||.   |   |. |  .|     ||.| .| |||.|  |. |.||.| ||. . |.|| ||.|
kntefkknrykdvvcndktrvilkd..GydGdyvhanyvk.....GlkamfiltqGalkdtvidiwrmvlqekvaaivmlcelie
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 140-224 2.1e-12 41.4 In-house 45-124 (305) alignment 
Range on Protein: 140-224
Range on HMM: 45-124/305.0
KIQNIHKNRYNASIPFDDNVISLKEPsvYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. |. .||||     .|.| . |. |  .   || |  . | .      ..| || ||. | .||| . .|..   |.|| .|.|
eaqeagknrykdvgcldnnrvklegp..wpheyihanyvstptn...pkrfictqaplektcadfwymclqdkveaifmlcnlle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 141-220 2.6e-12 40.9 In-house 94-169 (244) alignment 
Range on Protein: 141-220
Range on HMM: 94-169/244.0
IQNIHKNRYNASIPFDDNVISLKEPSVyGSTYINASPIKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
 .| .|||  |..||| | . | . |. | |||||| .      |  |.|| || ||  |  |||... .    ....| 
pnnswknregaglpfdfnrvplskgsm.gntyinasfvgcl...grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlg
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 140-224 4.1e-12 40.4 In-house 53-132 (305) alignment 
Range on Protein: 140-224
Range on HMM: 53-132/305.0
KIqNIHKNRYNASIPFDDNVISLKEPSvyGSTYINASPIKTASTGglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
.| .| ||||.     | ... |..||   | || |  .        . ..|..||||| || .|| .| |..   |.||   ||
di.aitknryqdvpcqdqsavkldkps..psdyihanyvgcpmip..ekrficaqgpldqtidefwwmviqnkveqivmlcktve
subfamily_egg_pd Subfamily egg 167-223 2.7e-11 37.7 In-house 65-118 (307) alignment 
Range on Protein: 167-223
Range on HMM: 65-118/307.0
VYGSTYINASPIKtasTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELV
 |   .| |  .|    . |  ..| .| ||  |  ||||.|.||.   |.|||  .
qylddfihanrvk...Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 142-225 4.2e-11 37.4 In-house 40-119 (307) alignment 
Range on Protein: 142-225
Range on HMM: 40-119/307.0
QNIHKNRYNASIPFDDNVISLKEPSVyGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVEL
 | .||||.     | . | .| . .  | || |  . .|       ..|..||||..|. .|| .. ||.   .||| ...||
antdknryqdvkcqdkgrivvkfdgl.asdyihanylgiaik...pkkficaqgplentqysfwamaiqekvesvimlckviel
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 145-224 4.8e-11 37.1 In-house 37-111 (285) alignment 
Range on Protein: 145-224
Range on HMM: 37-111/285.0
HKNRYNASIPFDDNVISLKEpsvYGSTYINASPIKTasTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  |||      ..  . ||.   .   || || ..    |  |. ||.|||||  |.||||....||. . ..||  |.|
dlnryadvrcieetrvvlkn...hdrdyihaswmrm..pgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfe
0043147 (Phosphotyrosine protein) phosphatases II 169-222 7.5e-10 34.3 In-house 4-54 (172) alignment 
Range on Protein: 169-222
Range on HMM: 4-54/172.0
GSTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTEL
||.|||||....        ..|||||||. |..||||...... ..|..||||
gsdyinasyldlyy...ipdrfiatqgplrntladfwrmlkelgithivnltel
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 116-220 1.5e-09 31.9 In-house 18-116 (303) alignment 
Range on Protein: 116-220
Range on HMM: 18-116/303.0
KDHLNL-EQDFEELPSYLYSQ-DKGNKIQNIHKNRYNASIPFDDNVISLKEpsvygSTYINASPIKTAStgglQAQYIATQGPLDTTISDFWRLVWQEQS
..  |.  ..||.. |||  .  | . ..|..|||.   | .|   . | .     |.|| || ..  |    . . | || ||  | .|||... ... 
dedaniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd.....ssyihasylelds....skkailtqlplshtaadfwqmiieqkv

SII-IMLT
  . ..||
kcvllllt
0046846 (Phosphotyrosine protein) phosphatases II 166-224 2.6e-09 32.6 In-house 8-59 (176) alignment 
Range on Protein: 166-224
Range on HMM: 8-59/176.0
SVYGSTYINASPIKTAstgglqaQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  ....||||. | ..        .|||||||  |. ||........ .....|||.||
ldldldyinanlilgs.......rpiatqgplprtladflemlkelgitavvnlteeve
0051429 (Phosphotyrosine protein) phosphatases II 169-224 3e-09 32.5 In-house 3-57 (272) alignment 
Range on Protein: 169-224
Range on HMM: 3-57/272.0
GSTYINASPIKTAstgG---LQAQYIATQGPLDTTISDFWRLvWQEQSSIIIMLTELVE
 |.||||. ...    |   .   .....|||. |. ||||| .... . |..|....|
lsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeE
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 178-224 6.8e-09 29.9 In-house 83-126 (301) alignment 
Range on Protein: 178-224
Range on HMM: 83-126/301.0
IKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|.|    |   ..|||||||. |  ||| .. | .   |.||.. ||
ipts...GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkve
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 189-222 1.4e-08 28.5 In-house 237-270 (440) alignment 
Range on Protein: 189-222
Range on HMM: 237-270/440.0
QYIATQGPLDTTISDFWRLVWQEQSSIIIMLTEL
 .|||| |||.|. |||||| . . | |||| .|
afiatqmpldstvldfwrlvhdyristiimlnql
0049260 (Phosphotyrosine protein) phosphatases II 189-224 2.6e-08 29.2 In-house 10-45 (152) alignment 
Range on Protein: 189-224
Range on HMM: 10-45/152.0
QYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
..||||||.. |..||||.... . ..|.|||||.|
efiatqgpgpntladfwrmlkelgittivmltelle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 134-224 5.4e-08 27.2 In-house 34-118 (288) alignment 
Range on Protein: 134-224
Range on HMM: 34-118/288.0
SQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINAspiktasTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
 .   . |.|  ..||.     |   . |.. |  |  . . .       ..  . . | .| ||..||  .|... ...   |.||.||.|
idiidsfianptrdryenlprcditrvklsddpdfyiaanvvs.......sakykrrlicaqaPlngtieelWkmllesdveyivmlcelle
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 169-220 8.4e-08 26.1 In-house 69-117 (347) alignment 
Range on Protein: 169-220
Range on HMM: 69-117/347.0
GSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
  |||||| ||   .   . .|| || ||  |. |||..|   . . .. . 
vetyinashikfdna...skeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
0036282 (Phosphotyrosine protein) phosphatases II 169-224 1.9e-07 26.5 In-house 1-48 (174) alignment 
Range on Protein: 169-224
Range on HMM: 1-48/174.0
GSTYINASPIKTASTGGlqaQYIATQGPLDttisdFWRLVWQEQSSIIIMLTELVE
||.||||||..     .    .||.||||.     ||............||.|..|
gsdyinaspldlsyitp...rliagqgpla.....fwemlkelgittvvmlleeke
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 167-221 2.3e-07 24.5 In-house 87-140 (349) alignment 
Range on Protein: 167-221
Range on HMM: 87-140/349.0
VYGSTYINASPIKTASTGgLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTE
     ||||  .| .     . .||||| || .|. ||....  ..  ... |..
gklddyinanylkltris.vekkyiatqaPlPstvddfykvillngvklvlsLnd
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 187-220 6.1e-07 23.8 In-house 4-37 (199) alignment 
Range on Protein: 187-220
Range on HMM: 4-37/199.0
QAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
| .||||| ||  |..|||..||.  |  |.|. 
qrryiatqhplretmadfwqmvwetgsghivmvn
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 187-220 6.3e-07 23.8 In-house 3-36 (198) alignment 
Range on Protein: 187-220
Range on HMM: 3-36/198.0
QAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
| .||||| ||  |..|||..||.  |  |.|. 
qrryiatqhplretladfwqmvwetgsghivmvn
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 117-219 9.1e-06 19.3 In-house 24-124 (302) alignment 
Range on Protein: 117-219
Range on HMM: 24-124/302.0
DHLNLEQDFEELPSYLYSQDKGNKI-QNIHKNRYNASIPFDDNVISLKEPSvygSTYINASPIKTASTGglqAQYIATQGPL-DTT--ISDFWRLVWQEQ
|. .....|... .   . .| .   .|..||. .     |.|.. |..       |.||| ..  . .    . | .| |  |..  . .|||.|.||.
dtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaep...dsyvnaskvevPelt...rsiilaQlpkvdsedsveeFWrmvfqek

SSIIIML
   . .|
ivsvvil