Gene PTPN6-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP058_AA protein Get Run
AqueP058_AA_103-225 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 95-224 9.4e-45 147.9 In-house 2-134 (306) alignment
Range on Protein: 95-224
Range on HMM: 2-134/306.0
VHLLSPVLHNNEGHLPRDGEVKDHLNLEQDFEEL----PSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTASTGGLqAQY
..||.  ..... .| ...| ... ..|..||||     ..|.|...|.|..| .||||....|||.....||||||.||.||||. ||....|   ..|
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd.ksy

IATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
||||| |.||.|||||.||||.| .|.|.|. ||
iatqgclettvsdFWrmvwqensrvivmttkevE

0050432 (Phosphotyrosine protein) phosphatases II 85-224 7.6e-29 96.4 In-house 11-144 (308) alignment
Range on Protein: 85-224
Range on HMM: 11-144/308.0
APLRLKDETLVHLLSPVLHNNEGHLPRdgeVKDHLNLEQDFEELPSYLYSQD--KGNKIQNIHKNRYNASIPFDDNVISLkepSvYGSTYINASPIKTAS
..|  ....||. |   ...   .| .    .|  .||. ||||.|.  . .   ... .|..||||   .|.| . . |   .  ||.||||| ... |
lllfrdtsilvsslklsvldllkllek...aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...d.egsdYInAsyvdgys

tGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  .|. ..|||||||..|. ||||.||......|.|||.|||
.sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklve

0046845 (Phosphotyrosine protein) phosphatases II 120-224 4.6e-28 93.8 In-house 1-113 (284) alignment
Range on Protein: 120-224
Range on HMM: 1-113/284.0
NLEQDFEELPSYLY----SQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV--YGSTYINASPIKTA--STGGLQAQYIATQGPLDTTISDFWRLVWQE
.||..||||.|. .    | . ... .|..||||   .|.|.. . || ..    .|.||||| ...   .    . ..|||||||..|. ||||.||..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

QSSIIIMLTELVE
....|.|||||||
nvrvIVmltelve

0051299 (Phosphotyrosine protein) phosphatases II 116-224 4.8e-28 93.9 In-house 20-128 (288) alignment
Range on Protein: 116-224
Range on HMM: 20-128/288.0
KDHLNLEQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQ
..  .|.. ||||.|.|  ...  ... .|..||||   .|.|.. . |.  ..| ||.||||| |   ..  |. ..|||||||..|..||||.||...
ngltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi...dgynlkrkfIatqgPlpntvedFWrmvweqn

SSIIIMLTELVE
...|.|||.|||
vrvIvmltklve

DSPc_SM00195 122-224 7.3e-28 93.0 In-house 3-105 (263) alignment
Range on Protein: 122-224
Range on HMM: 3-105/263.0
EQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIM
...||.| ..    . ....| .| .||||.  .|.|.. . ||..    ||.||||. ||.|     . .||||||||..|..||||.||.|...||.|
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTELVE
||| .|
lteeee

PTPc_SM00194 122-224 7.3e-28 93.0 In-house 3-105 (263) alignment
Range on Protein: 122-224
Range on HMM: 3-105/263.0
EQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIM
...||.| ..    . ....| .| .||||.  .|.|.. . ||..    ||.||||. ||.|     . .||||||||..|..||||.||.|...||.|
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTELVE
||| .|
lteeee

subfamily_PTPRD_pd Subfamily PTPRD 116-224 2.1e-27 91.0 In-house 20-127 (564) alignment
Range on Protein: 116-224
Range on HMM: 20-127/564.0
KDHLNLEQDFEELPSYL-YSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQS
...|..|...... .    . .. || .| .||||.  ...| . . | | . . || ||||| |..  .   . .|||||||| .||.||||.||...|
nsdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrk...rkayIAtqgPlaetiedFWRmvweqns

SIIIMLTELVE
|.|.|||.|.|
stiVmltkleE

0036941 (Phosphotyrosine protein) phosphatases II 122-224 3.5e-27 90.9 In-house 16-114 (297) alignment
Range on Protein: 122-224
Range on HMM: 16-114/297.0
EQDFEELPSYLY--SQDKGNKIQNIHKNRYNASIPFDDNVISLkepSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIML
.. ||||...|.  | . ... .|..||||   .|.|.. . |   .  || ||||| .   .. .|. ..|||||||..|. ||||.||......|.||
lkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv...dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

TELVE
|||||
telve

0039614 (Phosphotyrosine protein) phosphatases II 116-225 6.6e-27 90.2 In-house 29-138 (297) alignment
Range on Protein: 116-225
Range on HMM: 29-138/297.0
KDHLNLEQDFEELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISL--KEPSVYGSTYINASPIktaSTGGL-QAQYIATQGPLDTTISDFWRLVWQEQ
..   |...||||.|.  ..  .....|..||||   .|.|.. . |  .. .. .|.||||| .   ..  | . ..|||||||. |. ||||.||...
nsktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv...dgydlltrkfIatqgPlpetvedFwrmvweqg

SSIIIMLTELVEL
...|.|||.||||
vtvivmLtklvel

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 119-224 7.7e-27 89.1 In-house 21-126 (288) alignment
Range on Protein: 119-224
Range on HMM: 21-126/288.0
LNLEQDFEELPSY--LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSI
 ....... |..     |...|.. .| .||||.  .|.| . . ||. . . |. ||||| |.       . .||||||||  |. |||.||.....| 
tgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk...kkkyiatqgPladtvndfWelvyenktst

IIMLTELVE
|.|||||||
ivmltelve

0047943 (Phosphotyrosine protein) phosphatases II 118-225 1.8e-26 88.6 In-house 11-114 (273) alignment
Range on Protein: 118-225
Range on HMM: 11-114/273.0
HLNLEQDFEELPSYL--YSQDKGNKIQNIHKNRYNASIPFDDNVISLkepSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSI
   |.. ||.|.|.   ..   .....|..||||   .|.|.. . |   .  || ||||| .   ..  |. ..|||||||. |. ||||.||......
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyv...dgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IIMLTELVEL
|.||||||||
iVmLtelvel

0045450 (Phosphotyrosine protein) phosphatases II 120-225 1.5e-25 86.0 In-house 28-144 (307) alignment
Range on Protein: 120-225
Range on HMM: 28-144/307.0
NLEQDFEELPSYLY----SQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSV--YGSTYINASPIKTA-----STGGLQAQYIATQGPLDTTISDFWRLV
 |.. ||.|.|.      . . ... .|..||||   .|.|.. . |. ..    .| ||||| ...      ..  |. ..|||||||. |. ||||..
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrml

WQEQSSIIIMLTELVEL
|......|.||||||||
weqgvtvivmltelvel

0040438 (Phosphotyrosine protein) phosphatases II 117-225 1.9e-25 85.3 In-house 16-123 (317) alignment
Range on Protein: 117-225
Range on HMM: 16-123/317.0
DHLNLEQDFEELPSYLY-SQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSS
|.  |.. ||.|.|. . . . ... .|..||||   .|.|.. . |.  .....|.||||| .   ..  |. ..|||||||. |. ||||.||.....
dftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv...dgpnlkrkfIatqgPlpntvedFwrmvweqgvt

IIIMLTELVEL
.|.|||||.||
vivmLteleel

0043336 (Phosphotyrosine protein) phosphatases II 124-225 1e-24 82.9 In-house 25-125 (278) alignment
Range on Protein: 124-225
Range on HMM: 25-125/278.0
DFEELPSY-LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTE
.||||.|. |.... .....|..||||   .|.| . . |.  .....|.||||| .   ..   . ..|||||||. |. ||||.||......|.||||
efeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv...dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLte

LVEL
||||
lvel

subfamily_PTPN12_pd Subfamily PTPN12 132-225 1.8e-24 81.1 In-house 29-120 (290) alignment
Range on Protein: 132-225
Range on HMM: 29-120/290.0
LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVEL
 ||...|.| .|..||||   .|.| . . |..  .. || ||||. || ..    . .|||.|||| .|..||||..|. . .|..|. ..|||
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg...kleyiaaqgPLpktlddfWrmiweknveivvmaCrevel

Y_phosphatase Protein-tyrosine phosphatase 143-224 2.9e-24 81.1 Pfam-A 1-78 (235) alignment
Range on Protein: 143-224
Range on HMM: 1-78/235.0
NIHKNRYNASIPFDDNVISLkEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
| .||||.  .|.|.. . | . |   | ||||. .|. ..   . ..|||||||. ||.||||.||||....|.|||.|.|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltslee

Y_phosphatase Protein-tyrosine phosphatase 143-224 2.9e-24 81.1 In-house 1-78 (235) alignment
Range on Protein: 143-224
Range on HMM: 1-78/235.0
NIHKNRYNASIPFDDNVISLkEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
| .||||.  .|.|.. . | . |   | ||||. .|. ..   . ..|||||||. ||.||||.||||....|.|||.|.|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltslee

subfamily_Ptp69D_pd Subfamily Ptp69D 119-224 6.9e-24 79.5 In-house 22-127 (307) alignment
Range on Protein: 119-224
Range on HMM: 22-127/307.0
LNLEQDFEELP--SYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSI
  |....|.|.      |   ..|  |  ||||.. ..||.. . ||. .    |.||||| ||.      . ..|| |.|...|| ||||.... .. .
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyke...kkkfiaaqdPveatigDfWRmiaeqevtl

IIMLTELVE
|.||..| |
ivmlsnlte

subfamily_PTPRB_pd Subfamily PTPRB 115-224 9.3e-24 79.0 In-house 21-130 (293) alignment
Range on Protein: 115-224
Range on HMM: 21-130/293.0
VKDHLNLEQDFEELPSYLY--SQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQE
 ...|.. ...||| .     .... .. .|  ||||.  .|.| . . |..  .  || ||||. |.  ..   . ..||||||| .|. ||||.||..
adsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyns...prefiatqGPlpetvddfWrmvwek

QSSIIIMLTELVE
.||||.|||.|||
kssiivmltqlve

0045098 (Phosphotyrosine protein) phosphatases II 122-225 1.1e-23 79.4 In-house 12-101 (278) alignment
Range on Protein: 122-225
Range on HMM: 12-101/278.0
EQDFEELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISlkepsvygsTYINASPIKTAstgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTE
| .|  |... ..   .... |..||||   .|.| . .           ||||| |..      . ..|||||||..|..||||..|......|.||||
efefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy.....pkkfIatqgPlpstvadfwrmlwelgitvivmlte

LVEL
||||
lvel

subfamily_PTPN3_pd Subfamily PTPN3 137-224 1.2e-23 78.4 In-house 35-120 (280) alignment
Range on Protein: 137-224
Range on HMM: 35-120/280.0
KGNKIQNIHKNRYNASIPFDDNVISLKEPSVygsTYINASPIKTASTG-GLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. .| .|..||||   .|.|.  ..||| ..    ||||. ..  . . ||  .||||||||..| .|||..||...||.|.|||.|||
aarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlve

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 118-224 1.3e-23 78.5 In-house 19-125 (318) alignment
Range on Protein: 118-224
Range on HMM: 19-125/318.0
HLNLEQDFEEL--PSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSS
.|.|....|.|   .   .. | ..  | .||||.  ...|.  . |..  .. || ||||. |        . .|||.|.||  ||.||||.||. .|.
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrr...kkayiaaqaPlpetieDfWrmvWeqnsa

IIIMLTELVE
.|.|||...|
vivmltqeee

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 118-224 1.8e-23 78.0 In-house 4-109 (274) alignment
Range on Protein: 118-224
Range on HMM: 4-109/274.0
HLNLEQDFEELPSYLySQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY--GSTYINASPIKTAStgGLQAQYIATQGPLDTTISDFWRLVWQEQSSI
  .||..| |||.   .|.. .   . .||||.. .| .   ..|.. |.    |.||||  ||  .  . .  |.|||||| .|..||||...||....
fkdlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGyd..eeskayvatqGPlpntvadfWrmiyqeevqv

IIMLTELVE
|.|||.| |
ivmltklke

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 120-224 2.3e-23 77.8 In-house 24-127 (319) alignment
Range on Protein: 120-224
Range on HMM: 24-127/319.0
NLEQDFEELPSY-LYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIII
 ||..|..|      . |. .| .| .||||.  ...|   . |.| . | ||.||||| | .      . ..||||.||..||.||||.||.|.|||..
llekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqe...rekfiatqaPlentiedfWrmvWeeessivv

MLTELVE
|||.|||
mltklve

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 134-224 5.1e-23 76.7 In-house 47-135 (298) alignment
Range on Protein: 134-224
Range on HMM: 47-135/298.0
SQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTGGlqaQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
... ..| .| .||||   |..|   . |..  .   |.||||| .....       .||||.|| .|..||||.|..|... |.|||.|.|
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn...afiatqaPltetvedFWrmvteedigtiVmltnlee

0040439 (Phosphotyrosine protein) phosphatases II 137-225 1.1e-22 76.3 In-house 5-91 (249) alignment
Range on Protein: 137-225
Range on HMM: 5-91/249.0
KGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVEL
 ...  |..||||   .|.| . . |.  |....| ||||| |   ..   . ..|||||||. |..||||..|......|.|||.||||
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi...dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel

subfamily_PTPRN_pd Subfamily PTPRN 116-224 2.8e-22 73.8 In-house 26-136 (297) alignment
Range on Protein: 116-224
Range on HMM: 26-136/297.0
KDHLNLEQDFEELPSYLY---SQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTAStgGLQAQYIATQGPLDTTISDFWRLVWQE
|.. .||...| | .|     ... ... .|..|||..| .|.|.. ..|||  |   | |||||.|        .. |||||||| .|..|||..||..
knkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd..prapayiatqgplastvadfwqmvweq

QSSIIIMLTELVE
 . .|..||.| |
Gvvvivnltrlee

subfamily_PTPN14_pd Subfamily PTPN14 138-224 3e-22 74.0 In-house 44-129 (300) alignment
Range on Protein: 138-224
Range on HMM: 44-129/300.0
GNKIQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
..  .| .|||..  .|..|| . |.      . ||||| ||. | || . .||..||||..|. |||..||... ..|.||||  |
aklpenaeknrfkdvlPyednrvelsptkenstgyinassikv.svggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeee

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 127-220 3.8e-22 74.0 In-house 45-136 (319) alignment
Range on Protein: 127-220
Range on HMM: 45-136/319.0
ELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
.|.  |  |.  |  ||  |||.   ..|| ||. |.    . .| ||||| ..       . .|||.||||| |. ||||..|. ..| |..||
klgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqr...kdkyiaaqGPldntladfWrmiweyncstivllt

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 133-220 7.4e-22 73.1 In-house 15-100 (284) alignment
Range on Protein: 133-220
Range on HMM: 15-100/284.0
YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
  |   |  ||  |||.   ..|| ||. |.    . .| ||||| |.       . .||||||||| |. ||||..|. ..| |..||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqr...kdkyiatqGPldntladfWrmiweyncstivllt

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 121-224 1.8e-21 71.4 In-house 26-128 (315) alignment
Range on Protein: 121-224
Range on HMM: 26-128/315.0
LEQDFEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISL--KEpSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIII
..||.| .|   |.  |  .||.| .||||   |..|   . |   |    .| |.||. |.  .    . .|||.|||. ... ||||||..|. . |.
fkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlplle.ndphsdyvnanfidGynk...krryiaaqgpnvasvkdfwrlvfeedigkiv

MLTELVE
|||.|||
mltnlve

subfamily_PTPRA_pd Subfamily PTPRA 116-224 2e-21 71.2 In-house 29-137 (330) alignment
Range on Protein: 116-224
Range on HMM: 29-137/330.0
KDHLNLEQDFEELPS--YLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQ
 |   . ..|. ||.     . .  .| .| .|||.   .|.| . . | .   |  | ||||| |.       . ..||.|||.. |. ||||..|. .
ddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyke...kdkfiaaqGPkeetvedfwrmiweqk

SSIIIMLTELVE
|. |.||||| |
sativmltelke

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 121-223 2.6e-21 70.8 In-house 21-122 (315) alignment
Range on Protein: 121-223
Range on HMM: 21-122/315.0
LEQDFEELPSY-LYSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIM
. ..| .||    | |  . . .| .||||.  .|.| . . |        | ||||| ||.  .   .  |||.||||.....||||.|.||. . |.|
fseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd...dkayiasqgPlkasvddfwrmvlqekvttivm

LTELV
.|.. 
vtkkq

0042113 (Phosphotyrosine protein) phosphatases II 138-225 3.9e-21 71.0 In-house 4-89 (245) alignment
Range on Protein: 138-225
Range on HMM: 4-89/245.0
GNKIQNIHKNRYNASIPFDDNVISLKEPSVY-GSTYINASPIktaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVEL
.... |..||||   .|.|.. . |....   .|.|||||..   ..     ..|||||||. |. ||||..|......|.||||..||
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv...dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeel

subfamily_PTPRG_pd Subfamily PTPRG 119-224 4.1e-21 69.8 In-house 19-127 (563) alignment
Range on Protein: 119-224
Range on HMM: 19-127/563.0
LNLEQDFEELPSYLYSQ----DKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYGS--TYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQ
  ....||.| |   |.    .. .| .| .||||   ...|   ..|.. .   .   ||||. |.       . ..||||||| .|. ||||..|...
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqk...skafiatqgplkdtfddFWrmiWeqn

SSIIIMLTELVE
..||.|.|.|||
vaiivmitnlve

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 114-224 4.2e-21 70.4 In-house 17-125 (305) alignment
Range on Protein: 114-224
Range on HMM: 17-125/305.0
EVKDHLNLEQDFEELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYG-STYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQ
.|..  .||.....|..   | | |.| .| .|||... ...||. | |.| .  . | ||||| ... .    . .||..||||..|..|||||...|.
rvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykr...kkkyivaqgPlkntvadfWrliveek

SSIIIMLTELVE
 | |.|||.|||
vstivmltklve

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 138-224 5.8e-21 69.8 In-house 4-88 (250) alignment
Range on Protein: 138-224
Range on HMM: 4-88/250.0
GNKIQNIHKNRYNASIPFDDNVISLKEPS-VYGSTYINASPIKTASTGglqAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
..| || .||||   |..|   . |.. .    | ||||| ... .       .||||||| .|| ||||.|..|.|. |.|||.|.|
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder...kafiatqgPlqatiedfWrmvleeksgtivmLtnLke

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 139-224 1.8e-20 68.0 In-house 29-111 (283) alignment
Range on Protein: 139-224
Range on HMM: 29-111/283.0
NKIQNIHKNRYNASIPFDDNVISLKEPSVygsTYINASPIKTASTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
   .| .|||..  .| | ... ||  |    .||||. |  .     . .||..|.||| |. |||..|..|. . |.|||.| |
sadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 122-223 2.1e-20 67.3 In-house 21-121 (515) alignment
Range on Protein: 122-223
Range on HMM: 21-121/515.0
EQDFEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIML
 ..| .||   .| |   ..  | .||||.  .|.| . . |        | |.||| |..  .   .  |||.|||......||||||.||. . |.|.
seefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn...dkayiasqgPnkasvddfWrlvlqenvttiamv

TELV
|.| 
tklk

0037934 (Phosphotyrosine protein) phosphatases II 139-225 2.3e-20 68.7 In-house 6-85 (243) alignment
Range on Protein: 139-225
Range on HMM: 6-85/243.0
NKIQNIHKNRYNASIPFDDNVISLkepsvYGSTYINASPIKTAStgglqaQYIATQGPLDTTISD----FWRLVWQEQSSIIIMLTELVEL
....|..||||   .|.|.. . |      || ||||. |.         ..|||||||. |. |    |||..|......|.||||||||
llpenlsknrysdilpydhsrvkl.....egsdyinanliyvtp......rliatqgPlpetveddlasfwrmlwelgitvivmltelvEl

subfamily_PTPRK_pd Subfamily PTPRK 126-224 2.4e-20 67.6 In-house 26-122 (314) alignment
Range on Protein: 126-224
Range on HMM: 26-122/314.0
EELPSYLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY-GSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
||  |..   |  .| .| .|||..  ...|   . |.       | ||||. | .       |..|.|||||. |. ||||||..|... |.|||||||
eeyeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykr...paafivtqgPlqetvkdfWrlvydencasivmltelve





subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 137-224 2.4e-20 67.5 In-house 32-116 (287) alignment
Range on Protein: 137-224
Range on HMM: 32-116/287.0
KGNKIQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. ... ...||||   .|.||. . | . . .|| ||||  . .      . ..||.|||. .|. ||||.|....|. .|..|  ||
aaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytd...deafiaaqgPiaatvrdfwravletrsasvitmtreve

subfamily_PTPN23_pd Subfamily PTPN23 117-224 3.3e-20 67.1 In-house 13-119 (288) alignment
Range on Protein: 117-224
Range on HMM: 13-119/288.0
DHLNLEQDFEELPSYLYSQDKGNKI----QNIHKNRYNASIPFDDNVISLKepsVYGSTYINASPIKTASTGGlqAQYIATQGPLDTTISDFWRLVWQEQ
.. .|.. |.|| ..   . ... |     . .|||..  .|.| | . |.        ||||| .|  |.|    ..||||.||..|..|||..|....
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgc..PdfiatqaPlqstlnDFWlmvyeqk

SSIIIMLTELVE
||.|.||..  |
ssviVmllskee

subfamily_PTPN13_pd Subfamily PTPN13 134-224 3.5e-20 67.4 In-house 28-113 (273) alignment
Range on Protein: 134-224
Range on HMM: 28-113/273.0
SQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVygstYINASPIKTAStGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. ..|.| .| .||||   .|.|.  . |.. .     ||||| ||    |  . .|||.|||| .|..|||..||. ....|.|.|  .|
tcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpv.gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtleke

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 122-224 4.9e-20 66.3 In-house 23-124 (392) alignment
Range on Protein: 122-224
Range on HMM: 23-124/392.0
EQDFEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIML
 ..| .||.  .| |  ..|  |..||||.  .|.| . . |     .  | |.||| |..  .   .  |||.|||  ....||||.|.||. . |.|.
feefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdn...ekayiasqgpnaaslddfwrmvfqenvttiamv

TELVE
|.| |
tklke

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 124-222 5e-20 66.8 In-house 31-126 (297) alignment
Range on Protein: 124-222
Range on HMM: 31-126/297.0
DFEELPS-YLYSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY-GSTYINASPIKTASTgglqaQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTE
.|  ||.  ...| . .|  |..|.||. ..|.| . . |.       | |.||| .|.        ..|.|| | ..|. |||..|..|| |.|.||..
eflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.....rlittqmPmkatvadfWamvldeqvstivmlnd

L
.
d

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 133-224 8e-20 65.9 In-house 36-127 (290) alignment
Range on Protein: 133-224
Range on HMM: 36-127/290.0
YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVY---GSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
..   |.  .| ..||..  .. ||| | |.. |        ||||. ||  .    . ||||||||.  |. |||.|.|||...||.|||. .|
htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke...kkqyiatqgpvsntlvdFWkliwqekvtiivmltniie

SH2 SH2 domain 8-82 8.7e-20 61.2 Pfam-A 1-77 (77) alignment
Range on Protein: 8-82
Range on HMM: 1-77/77.0
WFHPNLSGFEAEELLKR-TVNGRFLFRPSQSNPRDCTLSIKTEGGVTHVRIKKNETG-YHLFPDEVFPNLNSFVHHY
|.| ..|. |||.||.    .| || |.|.|.| | |||....| |.|.||...|.| | .. .| | .|.  |.||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 143-224 5.3e-19 63.4 In-house 3-81 (237) alignment
Range on Protein: 143-224
Range on HMM: 3-81/237.0
NIHKNRYNASIPFDDNVISLKEPSVyGSTYINASPIKTAstGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|  ||||   . .| . . || .   || ||||. .|     |   .|||.||||...  |||..||||. |.|.||| |.|
nkiknrygnivaydhsrvvlkgags.gsdyinatylkgf..dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltglie

subfamily_PTPN1_pd Subfamily PTPN1 133-224 7.5e-19 62.5 In-house 22-107 (290) alignment
Range on Protein: 133-224
Range on HMM: 22-107/290.0
YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVygsTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
... . .. .|  .|||    |.|   | |.. ..    ||||| ..      .. .|| |||||  |.. ||..||...|  ..|| ..||
fptreaklpenrnlnryrdvspydhsrikleradn...dyinaslvelee...akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

subfamily_ptpA1_pd Subfamily ptpA1 136-220 3.4e-17 57.3 In-house 40-121 (418) alignment
Range on Protein: 136-220
Range on HMM: 40-121/418.0
DKGNKIQNIHKNRYNASIPFDDNVISLKEP-SVYGSTYINASPIKTAstggLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
 .|.| .|  ||||   .| .   . ||.     || ||||  |  |       |.|.|||||  ||.||||.||...  ||.||.
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga....ypkqfictqgplpntiadfwrmvwenrcriivmls

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 121-224 3.8e-17 56.9 In-house 17-121 (301) alignment
Range on Protein: 121-224
Range on HMM: 17-121/301.0
LEQDFEELPSYLYS-QDKGNKIQNIHKNRYNASIPFDDNVISLKEPS---VYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSII
.|....|| ..     . | . .| . ||..   ..||| | ||. .   .   .||||| |.  |    . ..||.|||.. |. |||||.|||. . |
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgyse...kkkfiaaqgpmkktlvdfWrliwqekpvsi

IMLTELVE
.|.|.| |
vmvtnlke

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 139-224 4.6e-17 56.9 In-house 16-100 (270) alignment
Range on Protein: 139-224
Range on HMM: 16-100/270.0
NKIQNIHKNRYNASIPFDDNVISLKEPS-VYGSTYINASPIKtaSTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. ... . |||.  .|     . |.| .    ..||||  ..     | ...|||..|||.||...|||..|.|... |.|.|.|.|
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvr..GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

subfamily_PTPN9_pd Subfamily PTPN9 141-224 6.4e-17 56.5 In-house 40-121 (297) alignment
Range on Protein: 141-224
Range on HMM: 40-121/297.0
IQNIHKNRYNASIPFDDNVISLK-EPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  |..||||.  . .|.  . |. ..    | ||||. .        .  .|||||||. |.|||||.||...  .|.| | .||
ranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykq...kkafiatqGplkktvsdfWrmvWeqevlvivmttrvve

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 140-224 6.8e-17 56.5 In-house 38-120 (281) alignment
Range on Protein: 140-224
Range on HMM: 38-120/281.0
KIQNIHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. .|..||||.  . .|   . . .. .   . ||||. ... .    ...|||||||. ... .||..||... |.|.|.|. .|
adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg...ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreie

0049772 (Phosphotyrosine protein) phosphatases II 136-222 1.8e-16 56.2 In-house 39-151 (314) alignment
Range on Protein: 136-222
Range on HMM: 39-151/314.0
DKGNKIQNIHKNRYNASIPFDdNVISLKEPSVYGSTYINASPIKTAstgglqAQYIATQGPLDTTISDF----------WRLV--WQEQSSIIIM-----
 ....  |..||||   .|.| |   |.  .|.|| ||||| ...        ..|||||||. |. ||          ||.|  .. .. .| |     
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------LTEL
                |..|
ladelsrLdaAlgKtpllil

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 109-224 2.6e-16 54.3 In-house 16-140 (350) alignment
Range on Protein: 109-224
Range on HMM: 16-140/350.0
LPRDGEVKDHLNLEQDFEeLPSYLYSqdKGNKIQNIHKNRYNASIPFDDNVISLK---------EPSVYGSTYINASPIKTASTGG-LQA--QYIATQGP
... ..|| .| || | |  ||  .     . ..   ||||.  .|.. . . ||         . |. .. ||||. .| .  .   ..  .|||||.|
itknstvksrlsLesdse.spsnDvi..lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaP

LDTTISDFWRLVWQEQSSIIIMLTELVE
|  |. ||.... . .  .|..||..||
lpstvddfykvillnkvkvilsltsdve

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 142-224 6.7e-16 53.1 In-house 46-122 (287) alignment
Range on Protein: 142-224
Range on HMM: 46-122/287.0
QNIHKNRYNASIPFDDNVISLKepsVYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|| .|||..  .. |.. . ||        ||||. |.. .    . ..|....|.  |. .||.|..... ..|.||... |
qnkdknRltqilvpdnyrvllk...gehpdyinavfidgyke...kkafiiaesPmfntarnfWkliddrnvtaivmlcqeke

subfamily_CG42327_pd Subfamily CG42327 122-224 1.7e-15 51.5 In-house 8-108 (319) alignment
Range on Protein: 122-224
Range on HMM: 8-108/319.0
EQDFEELPSYLYSQDkGNKIQNIHKNRYNASIPFDD-NVISLKEPSVYGSTYINASPIKTASTGglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
 ..|..||  . . |    .    |.|.  ..|. . .|.. . ..   . |..|| ..       ...|||.| .|. . |||||.||. || .|. ||
aeefrdlPqliarad.evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydda..pnsyiaaqvsledsssdfwrtvweqqsrvivqlt

ELVE
.| |
dlse

subfamily_CG7180_pd Subfamily CG7180 138-222 1.9e-15 51.3 In-house 37-119 (296) alignment
Range on Protein: 138-222
Range on HMM: 37-119/296.0
GNKIQNIHKNRYNASIPFDDNVISLKEPS-VYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTEL
| . .|. |||.   .|.| | . |..      | ||||. . .      ...|| |..| . |. .|||||..|..| ...||. 
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflk...kkeyivteapkketvdefWrlvydeeisavvvLtkt

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 124-222 3.5e-15 51.0 In-house 28-125 (325) alignment
Range on Protein: 124-222
Range on HMM: 28-125/325.0
DFEELPSYL-YSQDKGNKIQNIHKNRYNASIPFDDNVISLKEPSVYG-STYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLV--WQeqSSIIIML
.|. |||    ..    | .|. |||..  ...| . . |.     . | ||||| ...      .  ..|.| || .|| |.||||  |.  .|....|
efgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkk...kdvflaaqaPltatindlWrlvldWr..csvvvvl

TEL
 ||
nel

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 144-224 4.9e-15 49.9 In-house 49-127 (439) alignment
Range on Protein: 144-224
Range on HMM: 49-127/439.0
IHKNRYNASIPFDDNVISL-KEPSVYGSTYINASPIKTASTGGLqaqYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  ||||.   .||   . | . | |  | ||||  ||   .  |   ||||||| . |  ||||||...... |.|||.|||
qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddkl...yiatqgpkkettddfwrlviekktvtivmltnlve

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 141-221 5.6e-15 49.7 In-house 50-127 (310) alignment
Range on Protein: 141-221
Range on HMM: 50-127/310.0
IQNIHKNRYNASIPFDDNVISLKEPSVYGSTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTE
 ...|||||   .  |.  . ||        || |  .||     |.. .| .||||. || ||||...||..  |..|  
kkymhknrysdvvcldtsrvklkidksryedyihanyvktny...lrstficsqgplqhtiidfwrmifqeraesilllck

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 140-224 7.1e-15 49.8 In-house 5-88 (239) alignment
Range on Protein: 140-224
Range on HMM: 5-88/239.0
KIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|  |  ||||   . .| . . |.. |    | ||||| ..     |    |||||| . ..  ||||..|||.  .|.||| |.|
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdy..dgspkayiatqgcveissgdfwrmmwqerrcvivmltglie

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 140-224 8.1e-15 49.6 In-house 4-87 (239) alignment
Range on Protein: 140-224
Range on HMM: 4-87/239.0
KIQNIHKNRYNASIPFDDNVISLKEPSV-YGSTYINASPIKTAstGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|  |  ||||   . .| . . |.. |    | ||||| ..     |    |||||| . ..  ||||..|||.  .|.||| |.|
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdy..dgspkayiatqgcveissgdfwrmmwqerrcvivmltglie

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 142-224 9.6e-15 49.2 In-house 32-112 (297) alignment
Range on Protein: 142-224
Range on HMM: 32-112/297.0
QNIHKNRYNASIPFDDNVISLKEpSVYGSTYINASPIKTAsTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  ..||||.  . .||. . |.  .. .. ||||  .        . .|| .||||..|. |||.||....  .|.|...| |
sslrknryrdilatddtrvkllr.viterdyinadyvvfp.deeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqe

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 121-221 1.3e-13 45.6 In-house 8-105 (267) alignment
Range on Protein: 121-221
Range on HMM: 8-105/267.0
LEQDFEELPSYLYSQDK---GNKIQNIHKNRYNASIPFDDNVISLKEPSVYgstYINASPIKTASTGglqAQYIATQGPLDTTISDFWRLVWQEQSSIII
.|..||..      . .       .|  .||.. ..|.||... |..       ||||| ...  |.    ..|.||.||. ||.||. .. ... ..|.
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyktk...nafivtqdplkntitdfltvihdqkvpviv

MLTE
.|| 
lltk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 122-224 1.8e-13 44.8 In-house 14-117 (281) alignment
Range on Protein: 122-224
Range on HMM: 14-117/281.0
EQDFEELPSYLYSQD--KGNKIQNIHKNRYNASIPFDDNVISLKE--PSVYGSTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSSIII
.|.| .||    |.     |.  | .||||     .|   . ||   |    . || |  |..     |.  || ||||   | .||||..|||... |.
kqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf...lkrgyiltqgpkketradfwrmiwqenttaiv

MLTELVE
|| ...|
mlcqfle

0041856 (Phosphotyrosine protein) phosphatases II 143-222 2.7e-13 45.4 In-house 1-68 (182) alignment
Range on Protein: 143-222
Range on HMM: 1-68/182.0
NIHKNRYNASIPFDDNVislkepsvyGSTYINASPIKTASTGGLqaqYIATQGPLDTTISDFWRLVWQEQSSIIIMLTEL
|..||||   .|.| .          ...||||. .  .  .     .|||||||. |. ||.|...... ..|..||| 
nldknrysdilpydhsr.........dldyInanlylgslpatr...fiatqgpllstvadflrmlkelgittivnltee

subfamily_eak_pd Subfamily eak 115-225 8.3e-13 42.4 In-house 25-130 (332) alignment
Range on Protein: 115-225
Range on HMM: 25-130/332.0
VKDHLNLEQDFEELPsYLYSQDKGNKIQNIHKNRYNaSIPFDDNVISLKEPSVYGSTYINASPIKTASTGglqAQYIATQGPLDTTISDFWRLVWQEQSS
.....|. .|...    | |. ..........| ..  .|.| . . |         ||||| .. .  |    .|| |  . .. .  ||..| ...| 
inqrinivadlddyq.rllsisetarleavnrnvvk.ivpydrylvrltssqlnrlGyinaslaefsevG...rkyiltGiasedkvfafwqmvleqksp

IIIMLTELVEL
 |..| | |||
aivqlledvel

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 140-224 1.5e-12 41.8 In-house 53-130 (290) alignment
Range on Protein: 140-224
Range on HMM: 53-130/290.0
KIQNIHKNRYNASIPFDDNVISLKEpsVYGSTYINASPIKtastgGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|  ...||||   .  |   . ||.   |   |. |  .|     ||.| .| |||.|  |. |.||.| ||. . |.|| ||.|
kntefkknrykdvvcndktrvilkd..GydGdyvhanyvk.....GlkamfiltqGalkdtvidiwrmvlqekvaaivmlcelie

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 140-224 2.1e-12 41.4 In-house 45-124 (305) alignment
Range on Protein: 140-224
Range on HMM: 45-124/305.0
KIQNIHKNRYNASIPFDDNVISLKEPsvYGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
. |. .||||     .|.| . |. |  .   || |  . | .      ..| || ||. | .||| . .|..   |.|| .|.|
eaqeagknrykdvgcldnnrvklegp..wpheyihanyvstptn...pkrfictqaplektcadfwymclqdkveaifmlcnlle

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 141-220 2.6e-12 40.9 In-house 94-169 (244) alignment
Range on Protein: 141-220
Range on HMM: 94-169/244.0
IQNIHKNRYNASIPFDDNVISLKEPSVyGSTYINASPIKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
 .| .|||  |..||| | . | . |. | |||||| .      |  |.|| || ||  |  |||... .    ....| 
pnnswknregaglpfdfnrvplskgsm.gntyinasfvgcl...grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlg

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 140-224 4.1e-12 40.4 In-house 53-132 (305) alignment
Range on Protein: 140-224
Range on HMM: 53-132/305.0
KIqNIHKNRYNASIPFDDNVISLKEPSvyGSTYINASPIKTASTGglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
.| .| ||||.     | ... |..||   | || |  .        . ..|..||||| || .|| .| |..   |.||   ||
di.aitknryqdvpcqdqsavkldkps..psdyihanyvgcpmip..ekrficaqgpldqtidefwwmviqnkveqivmlcktve

subfamily_egg_pd Subfamily egg 167-223 2.7e-11 37.7 In-house 65-118 (307) alignment
Range on Protein: 167-223
Range on HMM: 65-118/307.0
VYGSTYINASPIKtasTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELV
 |   .| |  .|    . |  ..| .| ||  |  ||||.|.||.   |.|||  .
qylddfihanrvk...Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrk

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 142-225 4.2e-11 37.4 In-house 40-119 (307) alignment
Range on Protein: 142-225
Range on HMM: 40-119/307.0
QNIHKNRYNASIPFDDNVISLKEPSVyGSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVEL
 | .||||.     | . | .| . .  | || |  . .|       ..|..||||..|. .|| .. ||.   .||| ...||
antdknryqdvkcqdkgrivvkfdgl.asdyihanylgiaik...pkkficaqgplentqysfwamaiqekvesvimlckviel

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 145-224 4.8e-11 37.1 In-house 37-111 (285) alignment
Range on Protein: 145-224
Range on HMM: 37-111/285.0
HKNRYNASIPFDDNVISLKEpsvYGSTYINASPIKTasTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  |||      ..  . ||.   .   || || ..    |  |. ||.|||||  |.||||....||. . ..||  |.|
dlnryadvrcieetrvvlkn...hdrdyihaswmrm..pgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfe

0043147 (Phosphotyrosine protein) phosphatases II 169-222 7.5e-10 34.3 In-house 4-54 (172) alignment
Range on Protein: 169-222
Range on HMM: 4-54/172.0
GSTYINASPIKTAStggLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTEL
||.|||||....        ..|||||||. |..||||...... ..|..||||
gsdyinasyldlyy...ipdrfiatqgplrntladfwrmlkelgithivnltel

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 116-220 1.5e-09 31.9 In-house 18-116 (303) alignment
Range on Protein: 116-220
Range on HMM: 18-116/303.0
KDHLNL-EQDFEELPSYLYSQ-DKGNKIQNIHKNRYNASIPFDDNVISLKEpsvygSTYINASPIKTAStgglQAQYIATQGPLDTTISDFWRLVWQEQS
..  |.  ..||.. |||  .  | . ..|..|||.   | .|   . | .     |.|| || ..  |    . . | || ||  | .|||... ... 
dedaniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd.....ssyihasylelds....skkailtqlplshtaadfwqmiieqkv

SII-IMLT
  . ..||
kcvllllt

0046846 (Phosphotyrosine protein) phosphatases II 166-224 2.6e-09 32.6 In-house 8-59 (176) alignment
Range on Protein: 166-224
Range on HMM: 8-59/176.0
SVYGSTYINASPIKTAstgglqaQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
  ....||||. | ..        .|||||||  |. ||........ .....|||.||
ldldldyinanlilgs.......rpiatqgplprtladflemlkelgitavvnlteeve

0051429 (Phosphotyrosine protein) phosphatases II 169-224 3e-09 32.5 In-house 3-57 (272) alignment
Range on Protein: 169-224
Range on HMM: 3-57/272.0
GSTYINASPIKTAstgG---LQAQYIATQGPLDTTISDFWRLvWQEQSSIIIMLTELVE
 |.||||. ...    |   .   .....|||. |. ||||| .... . |..|....|
lsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeE

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 178-224 6.8e-09 29.9 In-house 83-126 (301) alignment
Range on Protein: 178-224
Range on HMM: 83-126/301.0
IKTAstgGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
|.|    |   ..|||||||. |  ||| .. | .   |.||.. ||
ipts...GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkve

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 189-222 1.4e-08 28.5 In-house 237-270 (440) alignment
Range on Protein: 189-222
Range on HMM: 237-270/440.0
QYIATQGPLDTTISDFWRLVWQEQSSIIIMLTEL
 .|||| |||.|. |||||| . . | |||| .|
afiatqmpldstvldfwrlvhdyristiimlnql

0049260 (Phosphotyrosine protein) phosphatases II 189-224 2.6e-08 29.2 In-house 10-45 (152) alignment
Range on Protein: 189-224
Range on HMM: 10-45/152.0
QYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
..||||||.. |..||||.... . ..|.|||||.|
efiatqgpgpntladfwrmlkelgittivmltelle

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 134-224 5.4e-08 27.2 In-house 34-118 (288) alignment
Range on Protein: 134-224
Range on HMM: 34-118/288.0
SQDKGNKIQNIHKNRYNASIPFDDNVISLKE-PSVYGSTYINAspiktasTGGLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTELVE
 .   . |.|  ..||.     |   . |.. |  |  . . .       ..  . . | .| ||..||  .|... ...   |.||.||.|
idiidsfianptrdryenlprcditrvklsddpdfyiaanvvs.......sakykrrlicaqaPlngtieelWkmllesdveyivmlcelle

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 169-220 8.4e-08 26.1 In-house 69-117 (347) alignment
Range on Protein: 169-220
Range on HMM: 69-117/347.0
GSTYINASPIKTASTgglQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
  |||||| ||   .   . .|| || ||  |. |||..|   . . .. . 
vetyinashikfdna...skeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

0036282 (Phosphotyrosine protein) phosphatases II 169-224 1.9e-07 26.5 In-house 1-48 (174) alignment
Range on Protein: 169-224
Range on HMM: 1-48/174.0
GSTYINASPIKTASTGGlqaQYIATQGPLDttisdFWRLVWQEQSSIIIMLTELVE
||.||||||..     .    .||.||||.     ||............||.|..|
gsdyinaspldlsyitp...rliagqgpla.....fwemlkelgittvvmlleeke

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 167-221 2.3e-07 24.5 In-house 87-140 (349) alignment
Range on Protein: 167-221
Range on HMM: 87-140/349.0
VYGSTYINASPIKTASTGgLQAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLTE
     ||||  .| .     . .||||| || .|. ||....  ..  ... |..
gklddyinanylkltris.vekkyiatqaPlPstvddfykvillngvklvlsLnd

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 187-220 6.1e-07 23.8 In-house 4-37 (199) alignment
Range on Protein: 187-220
Range on HMM: 4-37/199.0
QAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
| .||||| ||  |..|||..||.  |  |.|. 
qrryiatqhplretmadfwqmvwetgsghivmvn

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 187-220 6.3e-07 23.8 In-house 3-36 (198) alignment
Range on Protein: 187-220
Range on HMM: 3-36/198.0
QAQYIATQGPLDTTISDFWRLVWQEQSSIIIMLT
| .||||| ||  |..|||..||.  |  |.|. 
qrryiatqhplretladfwqmvwetgsghivmvn

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 117-219 9.1e-06 19.3 In-house 24-124 (302) alignment
Range on Protein: 117-219
Range on HMM: 24-124/302.0
DHLNLEQDFEELPSYLYSQDKGNKI-QNIHKNRYNASIPFDDNVISLKEPSvygSTYINASPIKTASTGglqAQYIATQGPL-DTT--ISDFWRLVWQEQ
|. .....|... .   . .| .   .|..||. .     |.|.. |..       |.||| ..  . .    . | .| |  |..  . .|||.|.||.
dtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaep...dsyvnaskvevPelt...rsiilaQlpkvdsedsveeFWrmvfqek

SSIIIML
   . .|
ivsvvil