Gene PTPRD-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP062_AA protein Get Run
AqueP062_AA_83-358 phosphatase_domain Get Run
AqueP062_AA_370-652 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 78-436 4.7e-137 453.0 In-house 2-359 (564) alignment 
Range on Protein: 78-436
Range on HMM: 2-359/564.0
HPPLNVSDFIEMMALLQSNNSDRLEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLK-PDGNPGSDYINASFIGGLNSPKDYIATQGPIP
..|..|... | .| |..|.. ..|||| .|| . .||  ||. |.|  |||| ||..|||||| |.  .|..|||||||||| | ...| |||||||..
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

AAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLqSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLL
 .. |||||.||.|. ||.|.|.|.| .| |||.|||. | ..||...|||.| |..||| ||||.| . . .   .||||.||  |||||||..||.||
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslL

SFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIATL
.. ..||.... . ||.|||||||||||||||.|| |. .| .|. |||...|. .|  ||.|||| .|| |.|.|||||. | .| ... .. ...  |
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

KEIAPSSGKTGFQSQFETLESSSPTDdDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLST
.|. . .. ||..  |. |.......   . . |. . |. | |  . |. .  |||||.
aeveedtemtgleleFqrLatakeie.leefavatkpknkkknrfsnilalescrvvlsa
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 82-395 3.5e-109 359.7 In-house 3-318 (318) alignment 
Range on Protein: 82-395
Range on HMM: 3-318/318.0
NVSDFIEMMALLQSNNSDRLEEEYPDI-ELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIPAAF
.|.|. . .. |... .  |.|||  .   | ..||. .  |.|. ||||.||..|||.|| |.. .|..|||||||..| | .. | |||.|.|.| ..
svedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpeti

PDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSlHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQ
.|||||.|| |  .|.|.|...|  |.|.|.|||| |. .||. .|.|||  ...|| .|.|...  ...   ..|||||.  |||.|||. .. ||.. 
eDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlv

KRVRNHH-KGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIATLKE
..|.. . | . ||.||||||||||||.||..|... .| ||..||.|..|. .|  || |||| .||.|.....|||... || . | .....|  |.|
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

IAPSSGKTGFQSQFETL
  | ||.| .. .|. |
qdpesgttemdaefqrl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 80-392 4.3e-103 339.7 In-house 4-318 (319) alignment 
Range on Protein: 80-392
Range on HMM: 4-318/319.0
PLNVSDFIEMMALLQSNNSDRLEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIPAA
...| .. | .  |.|. .  ||.|. ...   |.| . |. ..|. |||| ||..||..||.|.. || .|||||||||| | .  . .||||.|.  .
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

FPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSF
. |||||.||... ...|.|.|.|  |.|...|||.    .|| . |||.| |  .|| || ..|. . ..   .|| ..... ||||.||..|| || .
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

QKRVRNHHKG-KPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIATLK
 ||.|. ... . ||.|||||||||||||||..| |. ..  ||..|.|..|. .|  || |||. .|| |...|.|||. . || |   .. ... .|.
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

EIAPSSGKTGFQSQF
|  . .|.||.. .|
ekvadtgetgleref
0051299 (Phosphotyrosine protein) phosphatases II 78-357 8.5e-101 332.4 In-house 2-286 (288) alignment 
Range on Protein: 78-357
Range on HMM: 2-286/288.0
HPPLNVSDFIEMMALLQSNNSDRLEEEYPDIELEW-NFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGN-PGSDYINASFIGGLNSPKDYIATQGPI
. ...|.......  |. |.  .|.||. ..   . ..| .||.|| |. ||||..|.||||||| |.. .. .||||||||.| | |... .|||||| 
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLH---GQGPIKEVRQYHFLVWPDHGVPQYA
|  . |||||.||.||..|.|.|.| |....||.||||. |  .|| ..|||...|. .|| .||.... |.   |.|  ..|...|.. |||||||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
..||.| ..||.... ..||.|||||||||||||||..|.... ...|| ||....|. .| .|..|||| .|| |...|.||..
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 75-362 5e-100 330.1 In-house 20-304 (308) alignment 
Range on Protein: 75-362
Range on HMM: 20-304/308.0
DPNHPPLNVSDFIEMMalLQSNNSDRLEEEYPDIELEWN-FTSYAAKLPINHGKNRYVNIIPYDHSRVTLkpdgNPGSDYINASFIGGL--NSPKDYIAT
 ... .|.| |.....   . ... .||||. ..    . .. ..|.|| |. ||||..|.||||||| |    ..||||||||.. |   ..|. .|||
lvsslklsvldllkll..ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIat

QGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSF---GAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQgPIKEVRQYHFLVWPDHGV
||| |  . |||||.||.||..|.|.|.| |....||.||||.    |  .|| |.|||...|. .|| .||..|. | .. . ..|...|.. ||||||
qgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgv

PQYATPLLSFQKRVRNHHkgKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDT
|.....||.| ..||...  ..||.|||||||||||||||..|...  ...|| ||.|. |. .| .|..|||| .|| ||..|.|| .... |
Ppspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
subfamily_PTPRB_pd Subfamily PTPRB 80-359 1.8e-98 324.2 In-house 6-287 (293) alignment 
Range on Protein: 80-359
Range on HMM: 6-287/293.0
PLNVSDFIEMMALLQSNNSDRLEEEYPDIE-LEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTL-KPDGNPGSDYINASFIGGLNSPKDYIATQGPIPA
|.....| | .. .....  |. ||| ... .. . .  ||.|..|. |||| ||.||||||| | . ....|||||||..| |.|||...||||||.| 
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

AFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSF-GAANYGSFQVTLKEVETVADYAIRTFQLQSlhgQGPIKEVRQYHFLVWPDHGVPQYATPLL
.. |||||.|| .. .|.|.|.| |  |.||..|||.   . .||. .|||.. |.. |..||.....    .  ...||||||. |||||||. ...||
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktll

SFQKRVRNHH--KGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMC
.| ..||...  . . .|.|||||||||||||||..|... .|. | .|||| .|  .|  ||..||| .|| |.|...|. .. 
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0040438 (Phosphotyrosine protein) phosphatases II 85-392 1.8e-98 325.0 In-house 4-311 (317) alignment 
Range on Protein: 85-392
Range on HMM: 4-311/317.0
DFIEMMALLQSNNSDRLEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGN-PGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFW
|... . .|  ..  .|.||. |.      |   |.|| |..||||..|.||||||| |.|.|. ..|||||||.. | | .. .|||||| |  . |||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLhGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVR
||.||..| .|.|.|.|.|....||.||||. .  .|| |.|||...|. |.. .||.... | | ..  .|...|.. |||||||.. ..||.| ..||
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavr

NHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIATLKEIAPSS
.. ....||..||||||||||||||....|.. .. || ||... |. .| .|...||| .|| ||. |.|| .....| .|| . ..|.  |... . .
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplald

GKTGFQSQF
. .. ....
dvklkekel
subfamily_PTPRG_pd Subfamily PTPRG 82-378 2.3e-97 321.5 In-house 2-304 (563) alignment 
Range on Protein: 82-378
Range on HMM: 2-304/563.0
NVSDFIEMMALLQSNNSDRLEEEYPDIELEWNF---TSYAAKLPINHGKNRYVNIIPYDHSRVTLKPD-GNPGS-DYINASFIGGLNSPKDYIATQGPIP
.|..| . .| | ...  ...||. ... | .    .  ... | |. ||||.||..||.|||.|.|  |. .. |||||..| | .  |..||||||..
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

AAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLH---GQG--PIKEVRQYHFLVWPDHGVPQY
  | |||||||| || .|.|.|||.|. . ||..|||. .. .||..||||.| |..| |..||.... |.   ..     |.|||||.  |||||||..
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

ATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIpavhMAT
..| |.| |.    .| . ||.|||||||||||||.| .||.. .| .| .|..|.|.. .|  ||..|||  || ||| |.||||. ..| .    .|.
slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketel....lae

KIATLKE
..  ||.
qveelkn
0046845 (Phosphotyrosine protein) phosphatases II 105-363 6.7e-96 316.3 In-house 6-280 (284) alignment 
Range on Protein: 105-363
Range on HMM: 6-280/284.0
YPDIE---LEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGN--PGSDYINASFIGGL-----NSPKDYIATQGPIPAAFPDFWRMIWEYNVPTI
.  .      . .. ..|.|| |. ||||..|.||||||| ||. ..  ..|||||||.. |      ...| .|||||| |  . |||||.||.||..|
feellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvI

IMVTNLKEDDKIKCHQYWPSFG-AANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHK--GKPG
.|.|.| |....||.||||. |   .|| |.|||...|.  || .||..|. |.  |. ..|...|.. |||||||.....||.| . ||....  ...|
VmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpggg

PMVVHCSAGVGRTGTFITIDTMIMKIDAEG---IVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTT
|.|||||||||||||||..|...  ...||    ||... |. .| .|..|||| .|| |...|.||..... | 
pivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_PTPRK_pd Subfamily PTPRK 78-394 1.8e-95 314.4 In-house 1-314 (314) alignment 
Range on Protein: 78-394
Range on HMM: 1-314/314.0
HPPLNVSDFIEMMALLQSNNSDRLEEEYPDIELEWNftsyAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIP
|| . | | .. .|||. ...  . |||  .   |.    |||   |. |||. .|..||.|||.|.. ||.| ||||||..| . . |. .|.||||..
hpairvadllqsiallkraegygfkeeyeslfegwd....aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

AAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAAnYGSFQVTLKEVETVADYAIRTFQLQS-LHGQGPIKEVRQYHFLVWPDHGVPQYATPL
    ||||.....|  .|.|.|.|.|  ..|| .|||  .   || ..|.| |.|. |.. .|.|...   .||  |.||||..|| ||||.||..|| |
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIAT
|.. .|| .... . |..||||||| |||||||.||...  |. ||.||.|| |. .|  .  ||.|  || |.. .|||| .| .|.||. .. .    
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

LKEIAPSSGKTGFQSQFET
 ... | .  . .. .|.|
sirldpqtnssqlkeefqt
0036941 (Phosphotyrosine protein) phosphatases II 94-369 6.4e-95 313.1 In-house 8-289 (297) alignment 
Range on Protein: 94-369
Range on HMM: 8-289/297.0
QSNNSDRLEEEYPDIE-LEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLkpdGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVP
..... .|..|. ..  | .... ..|.|| |  |||| .|.||||.|| |   ...||||||||.. | . .. .|||||| |  . |||||.||.||.
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

TIIMVTNLKEDDKIKCHQYWPSF--GAANYGSFQVTLKEVET--VADYAIRTFQLQSLhGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKG
.|.|.|.| |....||.||||.   .  .|| |.|||..||.   .|| .||.... . | |. ..|...|.. |||||||.....||.| ..||...| 
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--KPGPMVVHCSAGVGRTGTFITIDTMIMKID---AEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHM
  ..||..|||||||||.||||..|.|.. ..    || |||...|. .| .|. .||| .|| ||..|.|| .....| .|.. .
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
subfamily_PTPRD_pd Subfamily PTPRD 403-656 1.8e-94 312.4 In-house 36-286 (564) alignment 
Range on Protein: 403-656
Range on HMM: 36-286/564.0
DDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNY--DSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQ
. | .. |. . | || |... .. .  |||||. .   .|||| ||..||||.| |.||||||...|  |||||||| .| .|.|||..||.|...  .
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPVNpNeEDMYGSFNvVALPEERALPDYIVRKFKLsHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQrKSGNGPITVHCSDGLGRTGT
||| . . .  ||..  | | ||  | ||..|.||| . |. ..||....|....||..  |..|||..||. .| ... ....|||.|||| | |||||
YWPek.g.tetygelt.Vtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGt

FCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDN
|...  .|||.|.|...|....||.|| ||.  |   .|| |||.| ||... ...
fividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
0045450 (Phosphotyrosine protein) phosphatases II 76-359 1.8e-93 308.9 In-house 4-306 (307) alignment 
Range on Protein: 76-359
Range on HMM: 4-306/307.0
PNHPPLNVSDFIEMMALLQSNNSDRLEEEYPDIELEWNF---TSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGN--PGSDYINASFI--------GGL
| ...... ... ...||. ..  .|..|. ..  .. |   . ..|.|| |. ||||..|.||||.|| |.. ..  ..|||||||..        .| 
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

NSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAA-NYGSFQVTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFL
.... .|||||| |  . |||||.||..| .|.|.|.|.|....||.||||. |   .|| |.|||...|. ..| .||. .. |.| |.  .|...|..
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

VWPDHGVPQYATPLLSFQKRVRNHHKG--KPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGI---VDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEA
 |||||||..  .||.| ..||....   |.||..||||||||||||||....|.  ...||.   ||... |. .| .|  .||. .|| ||..|.|| 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

IMC
...
llk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 88-364 3.5e-93 307.1 In-house 16-297 (298) alignment 
Range on Protein: 88-364
Range on HMM: 16-297/298.0
EMMALLQSNNSDRLEEEYPDIELEWN----FTSYAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDF
.. |  ....  ....|.  ..   .    ... .|. | |. |||| .||..|.||| |.  |..  ||||||||. . .  . .||||.|..... ||
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQgPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRV
|||..|... ||.|.|||.| ||.|.|.|||. |...||...|.|.. |. ||...|...... . .   .|||| || .|||.|||..|| .| . ..|
WrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkv

RNhHKGKPG--PMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTI
|  .. . |  |..|.|||||||.|||| ||... .. .|  ||.|. |. .|  |  .||| .|| |...|.|||. . .. |
ra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_PTPRA_pd Subfamily PTPRA 77-392 6.4e-93 306.2 In-house 10-330 (330) alignment 
Range on Protein: 77-392
Range on HMM: 10-330/330.0
NHPPLNVSDFIEMMALLQSNNSDRLEEEYPDIEL-EWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGP
...|| | .. | .   ..... .. ||.  .   . . |  .|.   |. |||.|||.|||.||| | . .|.. ||||||||| | .  . .||.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

IPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQ---GPIKEVRQYHFLVWPDHGVPQY
   .  ||||||||..  ||.|.|.||| .. ||.||||. |.  ||  .|...... . ||..| | .| |  .    . . |||.||  ||| |||  
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

ATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMAT
.  .|.. |.|.. .. . ||.|||||||||||||||..|... .. ||..||.|.||. .|  |  ||||  || |.....||  .  || . .. . .
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslek

KIATLKEIAPSSGKTGFQSQF
.. .|..  ..  |.|.. .|
hlqklynkitgtdkigleeef
0039614 (Phosphotyrosine protein) phosphatases II 76-362 2.1e-92 305.0 In-house 9-294 (297) alignment 
Range on Protein: 76-362
Range on HMM: 9-294/297.0
PNHPPLNVSDFIEMMALLQSNNSDRLEEEYPDIELEWNfTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGN--PGSDYINASFIGGLNS-PKDYIATQ
 ...|  .| .  .  |.. |.. .|..|. ..        . |.|| |  ||||..|.||||||| ||| ..  ..|||||||.. | .  ....||||
lesipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

GPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKiKCHQYWPSFGAaNYGSFQVTLKEVETVADYAIRTFQLQSlhgQGPIKEVRQYHFLVWPDHGVPQYA
|| |  . |||||.||..|..|.|.|.|.|... ||.||||. |  .|| |.|||..||. ..| .||. ..     |. ..|...... |||||||...
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppsl

TPLLSFQKRVRNHHKG--KPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDT
. ||.| . ||....   |.||..||||||||||||||....|.  .. || ||... |. .| .|...||| ||| ||..|.|| .....|
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0047943 (Phosphotyrosine protein) phosphatases II 94-357 2.9e-92 304.3 In-house 7-272 (273) alignment 
Range on Protein: 94-357
Range on HMM: 7-272/273.0
QSNNSDRLEEEYPDIEL-EWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLkpdGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVP
.......|.||. ..    ...| ..|.|| |. |||| .|.||||||| |   |..||||||||.. | |... .|||||| |  . |||||.||.||.
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

TIIMVTNLKEDDKIKCHQYWPSFG---AANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGpIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKG-
.|.|.|.| |....||.||||. |     .|| |.|||...|| .|| .||..|..|. .   ..|...|.. |||||||.. ..||.| . ||....  
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkaleal

-KPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
 ..||.|||||||||||||||..|...  . .|| ||... |. .| .| .|||| .|| ||..|.|| .
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 78-393 9e-92 302.3 In-house 3-315 (315) alignment 
Range on Protein: 78-393
Range on HMM: 3-315/315.0
HPPLNVSDFIEMMALLQSNNSDRLEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTL-KPDGNPGSDYINASFIGGLNSPKDYIATQGPIP
| |. . ..|  .|  ...  . ....|  |     .    ||   |. ||||.|||.||.||| |   . .|.|||.||.|| | | .. |||.||| .
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

AAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFgAANYGSFQVTLKEVETVADYAIRTFqlqSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLL
|.  ||||...|... .|.|.||| |..| |. .|||      || . ||.|. |   .|..||.   |   .  |.|| |.|.  ||| |||.|..||.
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplm

SFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIATL
 . ..|. ||. . |..||||||||||||||||.|... ...|| ..|..||..|.|  |  |||.| ||.|.. |.||...| ||.|       .  .|
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl

KEIAPSSGKTGFQSQFE
   .| .| | .| |||
lapspdtgstllqeqfe
0043336 (Phosphotyrosine protein) phosphatases II 80-356 4.8e-91 300.3 In-house 1-276 (278) alignment 
Range on Protein: 80-356
Range on HMM: 1-276/278.0
PLNVSDFIEMMALLQSNNSDRLEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIPAA
|..|.|...... |  |.  .|..|. ..   . .| . |.|| |. ||||..|.||||||| |.. .| ..|||||||.. | | |...|||||| |  
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPsFGAANYGSFQVTLKEVETVADYAIRTFQLQSlHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSF
. |||||.||..|.||.|.|.|.|....||.||||  |  .|| |.|||...|. .|| .||. .   .| |. ..|..||.| |||||||   ..||.|
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldf

QKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEA
 |.||.. . ..||..||||||||||||||....... .. || ||... |. .| .|  .||| ||| ||..|.|| 
lkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0050432 (Phosphotyrosine protein) phosphatases II 363-657 1.3e-90 299.2 In-house 19-305 (308) alignment 
Range on Protein: 363-657
Range on HMM: 19-305/308.0
TIPAVHMATKIATLKEIAPSSGKTGFQSQFETLESSSPtddDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLstkNYDSDYICASYVDGY--RQRSAFIA
. . ..  . .  || . .  ...... .||.| |  |   ....|.|.| .|  | | |  ||    ||.|   . .||||.|||||||  ... .|||
ilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIa

TQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPN-EEDMYGSFNVVALPEERaLPDYIVRKFKLSHSKNPdDSRTITHFQYINWPST
||||..|| .|||||||| .. .|.|||...||| |.  |||| ... .  .|| | |  | ||  |.||.||...|...... .|||.|||.|.|||  
tqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdg.esrtvthfhytnWpdh

SCPKEATSMIDLVADVVRIQrksGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDNY
..| ......|..  | . .   ..||| ||||.|.||||||.|. ..||.|..|. .|||..||.|| |||| |.. .||.|...|.||..... ..
gvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 91-357 3.8e-90 296.8 In-house 13-279 (288) alignment 
Range on Protein: 91-357
Range on HMM: 13-279/288.0
ALLQSNNSDRLEEEYPDI-ELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWE
|  . .| . ..|||  . .|| . .. |..|. |. |||| ||.|||. || ||  . ..|.||||||.| | .. | |||||||....  |||....|
akksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

YNVPTIIMVTNLKEDDKIKCHQYWPSFGA-ANYGSFQVTLKEVETVADYAIRTFQLQslhGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHK
... ||.|.|.| |..| ||..|||. .   ||||..|||.|.... |.  |.. |.    ..   |. ||..|.|||||||. ..||| . . | . ..
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

GKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
 . ||..||||||||||||||..|..| ....|  .|....|  .|  |. .||| .|| |.....|. |
adtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 101-401 4.1e-90 297.3 In-house 20-320 (515) alignment 
Range on Protein: 101-401
Range on HMM: 20-320/515.0
LEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTL-KPDGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTN
. ||. |.     .    |.  ||. |||| ||.||| .|| |   . || |||.|||.| .... | |||.||| .|.  ||||.....|| ||.|||.
fseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk

LKEDDKIKCHQYWPS--FGAANYGSFQVTLKEVETVADYAIRTFQLqsLHGQGpIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHC
|||.||||| .|||     . ..||..| |  .|. ..  .|....  |.|.  .. | |.||  |||.|||. .. || . | |.  |     |...||
lkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihc

SAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIATLKEIAPSSGKTGFQSQFETLES
|||||||| .|.|| .. ..    .||.||||. .|  | |.|||  || |.. |.|| .. |.| || .|.. ..  |.      |.. .  .|.||.|
saGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlks

SSPT
  | 
lcpd
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 362-657 1.3e-89 295.4 In-house 3-296 (298) alignment 
Range on Protein: 362-657
Range on HMM: 3-296/298.0
TTIPAVHMATKIATLKEIAPSSGKTGFQSQFETLESSSPTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLST--KNYDSDYICASYVDGYRQRSAFI
| | | .. ...  |... .. . ||....|..|.| | . ...  ..|. ..|  | |  . .. .  ||||..  .. .|||| ||....|..|.|||
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafi

ATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNpnEEDMYGSFNVvALPEERALPDYIVRKFKLSHSKNPdDSRTITHFQYINWPST
|||.|...|  ||||||.| ..  |.||||.|| .. .  .||| .  ... ||...|  | ..    |.||||.|.|..|.  ..|.. ......||. 
atqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitv.sllskeefadlivrklkvskkkee.kerevrqlhftsWpdk

SCPKEATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDNY
. |..|||..||...| . |...|| |..|.||.| ||.|||.|. .||||.|.|||.||| .||.||..||| |.  .|| ||..| ||....|...
gvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 92-358 3e-89 293.8 In-house 8-277 (281) alignment 
Range on Protein: 92-358
Range on HMM: 8-277/281.0
LLQSNNSDRLEEEYPDIEL-EWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPD-GNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEY
 |..|..  . ||| ...  . . |. |.| . |  ||||.||. ||..||...|.  |  .|||||.|. |....|.|||||||.||.. .||.|.||.
qlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

NVPTIIMVTNLKEDDKIKCHQYWPSFG-AANYGSFQVTLKEVETVADYAIRTFQLqsLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKG
.| .|.|||.  | .|.|||.|||    . .|| ..|. .. |. | |. |.|.|   . .|. .||.| ... |||||||. .. ||.|.| |.. .. 
kvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltek

-KPGPMVVHCSAGVGRTGTFITIDTMIMKIDAE-GIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIM
 .  |.|.|||||||||||.|..|... ...||   .|. . |. .|  ||.||||  ||.|...|.|.|..
ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 82-377 7.5e-89 292.9 In-house 5-303 (305) alignment 
Range on Protein: 82-377
Range on HMM: 5-303/305.0
NVSDFIEMMALLQSNNSDRLEEEYPDIELEwNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGNPG-SDYINASFIGGLNSPKDYIATQGPIPAAFP
...|. . .   ...... ||..|  .  | . .    |   |. |||...|...|..|. |... . . |||||||.. | .. | ||..|||..    
alddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntva

DFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAA--NYGSFQVTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSF
||||.|.|. | ||.|.|.|.|..| ||.||||   .   ..|.|.|.||. .|..|| .| ...   ...   . | ||..  ||||||||.|| |||.
dfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllsl

QKRVRNHHKGKPG-PMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIATLK
 |||....|   | |..|||||||||||.||..| .. .. .|..||.|. .. .|  | .||||  ||.||| |. | | | || |    .  ..  ||
ikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk
0051299 (Phosphotyrosine protein) phosphatases II 364-651 3.1e-87 287.9 In-house 5-286 (288) alignment 
Range on Protein: 364-651
Range on HMM: 5-286/288.0
IPAVHMATKIATLKeiapSSGKTGFQSQFETLESSSPTdddFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNY--DSDYICASYVDGYRQRSAFIAT
|.. ...  . .|.     .|.||.. .||.| |  |.   ...|.|.|  || | | .  || .. ||.||. .   .||||.|||.|||..  .||||
isveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIat

QGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVnpNEEDMYGSFNVVALPEERaLPDYIVRKFKLSHSK---NPDDSRTITHFQYINWPS
|||..|| .|||||||| .. .|.|||...|.| |.. ||||   ..  .|| . |  | ||  |.||.||...... .    .. |||.|||.|.||| 
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpd

TSCPKEATSMIDLVADVVRIQRkSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
 ..|  .....|.. .| . .. ||.||. ||||.|.||||||.|....||.|..|...||...||.|| |||| |.  .||.|...|.||..
hgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 382-655 3.4e-87 287.5 In-house 19-287 (319) alignment 
Range on Protein: 382-655
Range on HMM: 19-287/319.0
SSGKTGFQSQFETLESSSPTdddfDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTK--NYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEM
|.|.|... .|..|. ....    . . |.  .|  | | .. |. .  |||||.     .|||| ||..|||..|..|||||.|..||  |||||||| 
stgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWee

KSMIIIMLTNTEENGEEQSVQYWPVNpnEEDMYGSFnVVALPEERALPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQ
.|.|..|||.  |... .  .||| .  .   || . .| | ||. | |||.||.|| . ..  ..|...|||| .||    |..|||..||. .. . .
essivvmltklveklkvklkkywpee..nfeeyGrl.ivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksr

RKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFD
.|. .|||.||||.| ||||||.... .|||.| |.|.||||||..||.||.  |.  .||.||..| ||.|...|
ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0046845 (Phosphotyrosine protein) phosphatases II 387-657 1.1e-86 286.0 In-house 1-280 (284) alignment 
Range on Protein: 387-657
Range on HMM: 1-280/284.0
GFQSQFETLESSSPTDDdFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD---SDYICASYVDGY-----RQRSAFIATQGPMKNTAGDFWRMVWE
|.. .||.| |  ..   ...|.|.|  || | | |  || .. ||.|.. . |   |||| |||||||     ... .|||||||..|| .||||||||
gleeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe

MKSMIIIMLTNTEENGEEQSVQYWPVNpNEEDMYGSFNVVALPEERaLPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRI
 .. .|.|||...||| |.  |||| . .|  .|| | |  | ||   .||.||...|.. . .. |||.|||.|..||  ..| ......... .| ..
qnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrel

QRK-SGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQ---VIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDNY
... .|.||| ||||.|.||||||.|. ..||.|..|.   ..||...|| || ||||.|.  .||.|...|.||..... ..
lenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
DSPc_SM00195 115-357 2.4e-86 284.7 In-house 17-262 (263) alignment 
Range on Protein: 115-357
Range on HMM: 17-262/263.0
TSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDG-NPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWP
..  |. . |. |||| ||.||||.|| ||..  ..|||||||..| | |..|.||||||| |  . |||||.|| .|..|.|.|. .|..|.||..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

SF--GAANYGSFQVTLKEVETVA-DYAIRTFQLQSLHGqGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITI
.   |  ..|...|.|.|||..  .. .||..|.        ..|.||..  |||||||. ....|.. . |..... . ||.||||||||||||||.||
eesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvti

DTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
|... |...|  ||||. |. .|  |  ||||  || |...||||.|
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 115-357 2.4e-86 284.7 In-house 17-262 (263) alignment 
Range on Protein: 115-357
Range on HMM: 17-262/263.0
TSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDG-NPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWP
..  |. . |. |||| ||.||||.|| ||..  ..|||||||..| | |..|.||||||| |  . |||||.|| .|..|.|.|. .|..|.||..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

SF--GAANYGSFQVTLKEVETVA-DYAIRTFQLQSLHGqGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITI
.   |  ..|...|.|.|||..  .. .||..|.        ..|.||..  |||||||. ....|.. . |..... . ||.||||||||||||||.||
eesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvti

DTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
|... |...|  ||||. |. .|  |  ||||  || |...||||.|
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 102-395 2.9e-86 284.2 In-house 22-315 (315) alignment 
Range on Protein: 102-395
Range on HMM: 22-315/315.0
EEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTL-KPDGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNL
 ||. |.     .   .|. .||. |||| ||.|.|..|| |   | .| |||||||.| .... | |||.||| .|.  |||||.....| ||.|||..
seefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkk

KEDDKIKCHQYWPS--FGAANYGSFQVTLKEVETVADYAIRTFqlqSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCS
.|.||||| ||||     ....||..|.| ..|. .|  .| .    .      . | |..|  |||.||.. .. || . | |.  .. |  ...||||
qegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcs

AGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIATLKEIAPSSGKTGFQSQFETL
||||||| .|.|| .. .|  .  ||.||||. .|  | |.|||  .| |.. |.|| .. |.| |. .|.. ..  |.  .  ||.. .  .||||
aGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefetl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 118-359 4.8e-86 283.9 In-house 55-293 (319) alignment 
Range on Protein: 118-359
Range on HMM: 55-293/319.0
AAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTnlkeddKIKCHQYWPSFG
 | |. |  |||..||...|...| |.. .|  .||||||||. |  ... |||.||| . .  ||||||||||. ||...|      | || ||||  .
fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki

AANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHK--GKPGPMVVHCSAGVGRTGTFITIDTMI
  ... |.| .. ||  |.|..| ..|     .  |....|.||| |||.|||.|...|. . |.||  ..   .. ..||||||||||||..|..|...
vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvll

MKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMC
 ... |  ||..||||..|  || .||   || |.. |.||  . 
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
0036941 (Phosphotyrosine protein) phosphatases II 376-656 6.8e-86 283.5 In-house 3-282 (297) alignment 
Range on Protein: 376-656
Range on HMM: 3-282/297.0
LKEIAPSSGKTGFQSQFETLessSPTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLstKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRM
|| . ...........||.|    |   ....|.|.| .|| | | |  || .. ||.|  .. .||||.|||||||..  .|||||||..|| .|||||
lkllekllflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrm

VWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALPEERA-LPDYIVRKFKLSHSKNPdDSRTITHFQYINWPSTSCPKEATSMIDLVAD
||| .. .|.|||. .|.| |.  |||| . .|.  || | |  | .|   |.||..|...... .|. .|||.|||.|..||  ..|  ..|..|..  
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfiel

VVRIQRKS-GNGPITVHCSDGLGRTGTFCAMFTVLERLK---AEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDN
| ...... ..||. ||||.|.||.|||.|....|..|.    |. .|....||.|| |||| |   .||.|.. | ||.......
vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 119-360 3.3e-85 280.3 In-house 4-245 (250) alignment 
Range on Protein: 119-360
Range on HMM: 4-245/250.0
AKLPINHGKNRYVNIIPYDHSRVTLKPDG-NPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIkCHQYWPSFGA
|| | |. |||| .||..|.||| |...  .  ||||||||. | .  | .||||||..|.. |||||..|... ||.|.||||| .|  .|||||  .|
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

ANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGPiKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKG-KPGPMVVHCSAGVGRTGTFITIDTMIMK
 .||. .|.|.. |. ||| .|...| . . ..  . |||.||.|||| |||..||  | ..|.|.  ..  . .|..|.|||||||.|.||.||... .
ekyGdvtvsllskeefadytkrklklskakkade.rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

IDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCR
.  | .||.|.... .|  |  .|.. .|| |....||.|. . 
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
0045098 (Phosphotyrosine protein) phosphatases II 110-361 1.2e-84 279.2 In-house 19-276 (278) alignment 
Range on Protein: 110-361
Range on HMM: 19-276/278.0
LEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTlkpdgnpgsDYINASFIGGLnsPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCH
|  . . . | .. |  ||||..|.|||||||          ||||||.| |   || .|||||| |  . |||||.||.....|.|.|.|.|....||.
lgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

QYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSL---HGQGPIKEVRQYHFLVWPDHGVPQYA--TPLLSFQKRVRNHHK-------------GKPG
||||. |  .|| |.|||...|.. || .||. .. |   .  ..  .|...|.| ||||||| .   ...|.. ...|...|             ...|
qywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PMVVHCSAGVGRTGTFITIDTMIMKIdaEGIVDIFNFVRGMRFCRNY-MVQTASQYDFLHHAILEAIMCRD
|..||||||||||||.. ...|.  .  || ||... |. .| .|.. .||. .|| ||....|| .....
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
0040439 (Phosphotyrosine protein) phosphatases II 117-358 1.3e-84 279.0 In-house 4-247 (249) alignment 
Range on Protein: 117-358
Range on HMM: 4-247/249.0
YAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSF
. |.|| |. ||||..|.||||||| |.. .| ..|||||||.| | ......|||||| | ...|||||.||... .|.|.|.|.| ...||.||||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GAANYGSFQVTLKEVETVADYAIRTFQLQSLhGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKG--KPGPMVVHCSAGVGRTGTFITIDTM
|  .|| |.|||..||. .|| .||..|. | . |.  .|...... |||||||..  .||.| ..||....   |.||..||||||||||||||....|
gsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIM
.. .. |. ||... |. .| .|...||. .|| ||. |.|| ..
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 118-359 1.3e-84 279.1 In-house 19-257 (284) alignment 
Range on Protein: 118-359
Range on HMM: 19-257/284.0
AAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTnlkeddKIKCHQYWPSFG
 | |. |  |||...|...|...| |.. .|. .||||||||| |  ... ||||||| . .  ||||||||||. ||...|      | || ||||  .
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki

AANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHK--GKPGPMVVHCSAGVGRTGTFITIDTMI
  ... |.| .. ||  ..|..| ..|     .  |...||.||| |||.|||.|...|. . |.||  ..   .. ..||||||||||||..|..|...
vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvll

MKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMC
 ... |  ||..||||..|  || .||   || |.. |.||  . 
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
0047943 (Phosphotyrosine protein) phosphatases II 378-651 2.5e-84 278.2 In-house 4-272 (273) alignment 
Range on Protein: 378-651
Range on HMM: 4-272/273.0
EIAPSSGKTGFQSQFETLESSSPtddDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLstKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVW
 . ...|.|... .||.| |  |   ....|.|.| .|. | | |  || .. ||.|  .. .||||.|||||||..  .|||||||..|| .|||||||
llekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvw

EMKSMIIIMLTNTEENGEEQSVQYWPVNPNE-EDMYGSFNVVALPEERaLPDYIVRKFKLSHSKNPDdSRTITHFQYINWPSTSCPKEATSMIDLVADVV
| .. .|.|||...|.| |.  |||| . .| . .|| | |  | ||   .||.||...|....... |||.|||.| .||  ..|   .|..... .| 
eqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvr

RIQRKS-GNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
...... .|||. ||||.|.||||||.|....|..|..|. .||...|| || |||| |   .||.|...|.||..
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 382-657 7.6e-84 277.0 In-house 14-282 (317) alignment 
Range on Protein: 382-657
Range on HMM: 14-282/317.0
SSGKTGFQSQFETLESSSPTdddfDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNY--DSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEM
 |..|.....||.| | ..     ..|.|.| .|  | | .  ||  . ||.||  ..  |||||.||||||.... .|||||||..|| .|||||||| 
ksdftalleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq

KSMIIIMLTNTEENGEEQSVQYWPVnpNEEDMYGSFNVVALPEERaLPDYIVRKFKLSHSkNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQ
.. .|.|||..||.| |.. ||||   .|.  || | |  | ||  |.....|....... . ..|||.|||.|..||  ..|.  ....|..  | . .
gvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreal

RkSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDNY
. ...||. ||||.|.||||||.|....||.|. |. .||...||.|| |||| |   .||.|...|.||........
e.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 384-655 1.4e-83 275.5 In-house 20-287 (305) alignment 
Range on Protein: 384-655
Range on HMM: 20-287/305.0
GKTGFQSQFETLESSsPTDDDfdcsIAQLSDNLAKSRVKEHLPPND--YRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKS
 ..|.. |...| .  ..  |    . . . | ||.|.||  . .|  ...  . .. ||||| |||||||... ..|..|||.|||  ||||...|.| 
sdkgleaqykslyee.eesid....vgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekv

MIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVvALPEERALPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRK
  |.|||.. |.|...  |||| . .|.  .|.|.|  | .|.. .||| ||.|.|  .. ..|||....|  .||    |..|||...|. .| . |.|
stivmltklveggkdkCrqYWpesktekkefgefsv.elksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

SGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFD
. . |..||||.|.||||.|.|.   |||||.|.|.|||  .|.|| .|.. |.  ||| |.| |  | ....|
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
0042113 (Phosphotyrosine protein) phosphatases II 119-356 3.7e-83 274.0 In-house 4-242 (245) alignment 
Range on Protein: 119-356
Range on HMM: 4-242/245.0
AKLPINHGKNRYVNIIPYDHSRVTLKPDGNP-GSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGA
|.|| |. ||||..|.||||.|| |.|||.  .|||||||...| . .. .|||||| |  ..|||||.||... ||.|.|.. |....||.||||. . 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ANYGSFQVTLKEVETVADYAIRTFQLQSlHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHK-GKPGPMVVHCSAGVGRTGTFITIDTMIMK
 .|| |.|||...|. .|| .||....  .| .. .||..||.| ||||||| .   ||.| ..||.. . ...||..||||||||||||||....|.. 
ltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

IDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEA
...|. |.... |. .| .|  .||| ||| ||..|.|| 
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0045450 (Phosphotyrosine protein) phosphatases II 371-651 2.2e-82 272.5 In-house 12-304 (307) alignment 
Range on Protein: 371-651
Range on HMM: 12-304/307.0
TKIATLKEIAPSSGKTGFQSQFETLESSSPTDdDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNY---DSDYICASYV--------DGYRQRSAFI
.|.  |. . . ...||.. .||.| |  ...  ...|||.|  |  | | |. || .. ||.||. .    ||||| ||||        |||..  .||
lkllllvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfI

ATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNpNEEDMYGSFNVVALPEERaLPDYIVRKFKLSHSKNPDDSRTITHFQYINWPST
|||||...|  |||||.|| .. .|.|||...|.| |. .|||| . .|| .|| | |  | ||  |..|.||........  . |||.|||.|..|| .
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdh

SCPKEATSMIDLVADVVRIQRKS-GNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQV---IDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
..|.   ...|..  | ...... ..||. ||||.|.||||||.|....|..|..|..   .|....||.|| |||| |   .||.|...|.||..
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 124-355 2.4e-82 271.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 124-355
Range on HMM: 1-235/235.0
NHGKNRYVNIIPYDHSRVTLkpDGNPG-SDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWP--SFGAANY
|. |||| .|.|||..|| |  .|..| ||||||... | ...| .||||||..  . |||||.|...| .|.|.|.|.| .. ||.||||  . .  .|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GSFQVTLK-EVE-TVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKID
|...|.|| ...   ..|..|...|..  ..   .||.|.|.  |||||||. ...||.. ..|..... | ||.||||||||||||||...|.......
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

AEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILE
||. ||....|. .| .|. |||...|| ||..||||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 124-355 2.4e-82 271.2 In-house 1-235 (235) alignment 
Range on Protein: 124-355
Range on HMM: 1-235/235.0
NHGKNRYVNIIPYDHSRVTLkpDGNPG-SDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWP--SFGAANY
|. |||| .|.|||..|| |  .|..| ||||||... | ...| .||||||..  . |||||.|...| .|.|.|.|.| .. ||.||||  . .  .|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GSFQVTLK-EVE-TVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKID
|...|.|| ...   ..|..|...|..  ..   .||.|.|.  |||||||. ...||.. ..|..... | ||.||||||||||||||...|.......
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

AEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILE
||. ||....|. .| .|. |||...|| ||..||||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0039614 (Phosphotyrosine protein) phosphatases II 374-656 2.9e-82 271.8 In-house 20-294 (297) alignment 
Range on Protein: 374-656
Range on HMM: 20-294/297.0
ATLKEIAPSSGKTGFQSQFETLESSSPtdddfDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN---YDSDYICASYVDGYRQ-RSAFIATQGPMKNTA
. |. . . ..||... .||.| |  |     |.|||.|  |  | | |..|| .. ||.|....    |||||.|||||||..   .|||||||...| 
dlllllekansktllllefeellslkp.....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

GDFWRMVWEMKSMIIIMLTNTEENGEeQSVQYWPVNPNeedMYGSFNVVALPEERaLPDYIVRKFKLSHsknPDDSRTITHFQYINWPSTSCPKEATSMI
.|||||||| .. .|.|||...|.|  . .|||| . .   .|| | |  | .|  |..|.||......    . |||.|||||..||  ..|  .....
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslelll

DLVADVVRIQRKS-GNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDN
...  | ...... ..||. ||||.|.||||||.|....||.|. |. .||...||.|| |||| |   .||.|...|.||.......
eflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 383-658 3.8e-82 270.9 In-house 17-287 (318) alignment 
Range on Protein: 383-658
Range on HMM: 17-287/318.0
SGKTGFQSQFETLESSSPTDDDFDCsiaQLSDNLAKSRVKEHLPPNDYRVVLSTK--NYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMK
||.. .....| |. |. |   ..      . | || |    |. .. || |...  . .|||| |.|.||||.. |.||.|.|. .|  |||||||| .
sGelllseeyerlsrseetvtslks...lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqn

SMIIIMLTNTEENGEEQSVQYWPVNpnEEDMYGSFNvVALPEERALPDYIVRKFKLSHsKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQR
|..|.|||..||.| ..  .||| .  .   ||.   | | ||  | ||..|.||... .. ..||..  ..| .|| .. |....|..||| .| ..|.
savivmltqeeergkakvhryWPsk..gsrsygklv.velkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqq

KSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDNYD
|||.|||.|||| | ||||.|.|. ..|||.|||...||| |||.|| ||.  |   ||||||... ||.....| . 
ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 381-657 1.6e-80 265.1 In-house 15-289 (290) alignment 
Range on Protein: 381-657
Range on HMM: 15-289/290.0
PSSGKTGFQSQFETLESsspTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYDSD----YICASYVDGYRQRSAFIATQGPMKNTAGDFWRMV
 . |..||..||..|.|   .. ..   ..  |.|  . | .. ....|.|..|  .. . |    || |.|..||... ..||||||..||. |||...
hakgnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

WEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEdmYGSFNVVaLPEERALPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVV
|. |. ||.||||  |.|...  |||| .....  || |..  | .|..| .|| ||... .... ......|..|  ||.||   .. .... ... ..
wqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsik.llneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemy

RIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDNY
..|||.||..| |||||..||...|||. | ... | |.|||||. .|..|||.|| |.  .||..|..  |. ...|..|
ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
DSPc_SM00195 388-651 2.8e-80 264.8 In-house 2-262 (263) alignment 
Range on Protein: 388-651
Range on HMM: 2-262/263.0
FQSQFETLESSSPTDddfDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIII
.. .||.||.| ...   ... |. . | .| | |..|| .. || |....   .||||.|.|..|.......||||||...|  ||||||||.|. ||.
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALPEERALPDYIVRKFKLSHSKNpDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKSgNG
|||. ||||.|.  .||| . ...  .|...|    .|    ..|.|...|.. .. ...|..|..|| |||  ..|....|...|.  |   ...| .|
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sg

PITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|| ||||.|.||||||... ..|..|..|. .|.|..|| || |||| |.  .|| ||..|.||..
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 388-651 2.8e-80 264.8 In-house 2-262 (263) alignment 
Range on Protein: 388-651
Range on HMM: 2-262/263.0
FQSQFETLESSSPTDddfDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIII
.. .||.||.| ...   ... |. . | .| | |..|| .. || |....   .||||.|.|..|.......||||||...|  ||||||||.|. ||.
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALPEERALPDYIVRKFKLSHSKNpDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKSgNG
|||. ||||.|.  .||| . ...  .|...|    .|    ..|.|...|.. .. ...|..|..|| |||  ..|....|...|.  |   ...| .|
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sg

PITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|| ||||.|.||||||... ..|..|..|. .|.|..|| || |||| |.  .|| ||..|.||..
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 374-660 3.4e-80 264.1 In-house 8-287 (287) alignment 
Range on Protein: 374-660
Range on HMM: 8-287/287.0
ATLKEIAPSSGKTGFQSQFETLESSSPTDDDFDCSIAqlSDNLAKSRVKEHLPPNDYRVVLStkNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFW
. . .  .  |..||. || .||. . ..|.   .||  |.|  | |... |.|..|||.|   . . ||| |...|||... |||....|| ||| .||
gefvakghakgnegfknqftvleqvtqredevthnia..sqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnfW

RMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNeeDMYGSFNVVALPEErALPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTS-CPKEATSMIdLV
..... .  .|.||.. .|| ||.  |||| . .   ..| .|.  | ||    .||.||... .... .| .... .|. ||.||   .. .|... ..
kliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill.vi

ADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDNYDNF
 . .. |||.||..| |||||. ||...|||. | ... | | |||||. .|  |||.|| |  ..||.|| .. ||....|. | .|
eemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
0043336 (Phosphotyrosine protein) phosphatases II 381-651 3.6e-80 264.7 In-house 15-277 (278) alignment 
Range on Protein: 381-651
Range on HMM: 15-277/278.0
PSSGKTGFQSQFETLESSSPtdddFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWE
  ..||... .||.| |  .    ...|||.| .|  | | |  || .  ||.||  ..|  ||||.|||||||..  .|||||||...| .||||||||
llnlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwe

MKSMIIIMLTNTEENGEEQSVQYWPvnpNEEDMYGSFNVVALPEERaLPDYIVRKFKLSHsKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRI
 .. .|.|||. .|.| ....||||   ..   || | |  | ||  |.||.||...... .  . |||.||..|..||  ..|   ....|.. .| ..
lgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrea

QRkSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
.. . |||. ||||.|.||||||.|....||.|. |. .|....||.|| |||| |   .||.|...|.||..
le.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 83-376 6.7e-80 263.5 In-house 6-305 (307) alignment 
Range on Protein: 83-376
Range on HMM: 6-305/307.0
VSDFIEMMALLQSNNSDRLEEEYPDIE-LEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFP
. |  | .   . .    |..||  .|  | . .. ...   |  |||| .|...|. || ||.  |.  ||||||||| | .  |..|| |.|. |   
iddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatig

DFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQG----PIKEVRQYHFLVWPDHGVPQYATPLL
||||||.| .| .|.|..||.| .. ||..|||     .||.  |.| . |.  ||.||....   . ..      ..| |||.. |.|  ||. |. ||
DfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargll

SFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIATL
 . ..||...| . .|.||||||||||.|.|...| .. .. ||  ||||..|...|  || .||   || ||..|.|. ..  || .   ... .| .|
klieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
0037934 (Phosphotyrosine protein) phosphatases II 117-356 9.1e-80 263.0 In-house 3-241 (243) alignment 
Range on Protein: 117-356
Range on HMM: 3-241/243.0
YAAKLPINHGKNRYVNIIPYDHSRVTLkpdgnPGSDYINASFIGGLnsPKdYIATQGPIPAAFPD----FWRMIWEYNVPTIIMVTNLKEDDKIKCHQYW
. |.|| |. |||| .|.||||||| |     .|||||||..| ..  |. .|||||| |  . |    ||||.||... .|.|.|.|.| ...||.|||
siallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PsfGAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNH--------HKGKPGPMVVHCSAGVGRT
|  |  .|| |.|||...|. .|| .||..|. |  ... ..|..||.| |||||||.  ..||.| . ||..        .  . ||..||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFITIDTMIMKIdaeGiVDIFNFVRGMRFCRNY-MVQTASQYDFLHHAILEA
||.|....|....   | ||... |. .| .|.. .||| ||| ||..|.|| 
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN12_pd Subfamily PTPN12 111-357 5.1e-79 260.2 In-house 27-277 (290) alignment 
Range on Protein: 111-357
Range on HMM: 27-277/290.0
EWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCH
|  ... |.. . |  |||| .|.|||.|||.|.  ....|||||||.|| | .... |||.|||.|..  ||||||||.||  ..|. .. | .|.||.
ekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe

QYWPSFGAA--NYGSFQVTLKEVETVA-DYAIRTFQLQSlhgQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGT
.|||. |    ..|.|.|||.| ..|  |. |||....    |.  ..|.|.|.  |||||||. |..||.. . ||.... .  |.|||||||||||||
rYWpeegeeelefgefevtleeekavdddflirtLkvea...qkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGt

FITIDTMIMKIDAEGI---VDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
 |.|| . . . || |   .|.|. |. .|  |. .|||  || ....|..| .
iiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 79-369 8.6e-79 259.7 In-house 8-296 (297) alignment 
Range on Protein: 79-369
Range on HMM: 8-296/297.0
PPLNVSDFiemMALLQSNNSDR-LEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGN-PGSDYINASFIGGLNSpkDYIATQGPIP
 |. .|||    .|.| | .    .||. ..     ...  |.  .|  |.|| ||.||| |||.|.  .. | |||.||||. | .    .|.|| | .
rpiplsdf...atlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmk

AAFPDFWRMIWEYNVPTIIMVTNLKEDDKiKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQgPIKEVRQYHFLVWPDHGVPQ--YATP
|.  |||.|.....| ||.|.....| || || .||.  | ...|.  |.|. |.    .  |.....  . .   . |.||.|. |||. |..   |. 
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkak.arrvvkqyqfveWPdkaverkdsass

LLSFQKRVRNHHKGKPG-PMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHM
|| . . ||......   |..|||.||||||| ..||| .. ..  |  ||||..|. .|  | |.|||  || |.. |.|||... || |.| ..
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 408-658 1.1e-78 258.9 In-house 2-249 (250) alignment 
Range on Protein: 408-658
Range on HMM: 2-249/250.0
SIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEqSVQYWPVN
|.|.  .|. | |  . .. .  |||| ...   .|||| ||...||..|.||||||||...|  ||||||.| ||  |.|||| .|....   |||||.
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

PNEedMYGSFNVVALPEErALPDYIVRKFKLSHSKNpDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMF
  |   ||.  |  | .|    ||..||.|||. |.  |.|.. ......||  . |..||....|. .| . |...||.|. |.|| | ||.|.|.|. 
kae..kyGdvtvsllske.efadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid

TVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDNYD
.|||||| |.|.|||  .|.||..||. |.  .|| |.....|........| 
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_PTPN6_pd Subfamily PTPN6 101-357 9.1e-78 256.3 In-house 28-297 (306) alignment 
Range on Protein: 101-357
Range on HMM: 28-297/306.0
LEEEYPDI---ELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGNPGSDYINASFIG--GLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTII
.|||. ..   | .  ..   .. | |. |||| ||.|.||.||.|| .. ||||||||..|     .| | |||||| ...  .|||||.|. |   |.
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrviv

MVTNLKEDDKIKCHQYWPSFGA-ANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKP----
|.|.  |  | || .|||.  .  .||. .||  . .. ||| .|.....  . ..  .||.|||| .|||||||.    .|.| . |.....       
mttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaea

GPMVVHCSAGVGRTGTFITIDTMIMKIDAEGI---VDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
||.|||||||.||||||| ||... .|  .|.   .|| ..|. .|  |. .|||..|| |...|| . |
gpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 123-363 3.7e-77 254.1 In-house 46-284 (287) alignment 
Range on Protein: 123-363
Range on HMM: 46-284/287.0
INHGKNRYVNIIPYDHSRVTLKpdgNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGS
 |. |||. .|...|  || ||   .   |||||.|| | .. | .|....|.  .  .||..|.. ||..|.|....||.|. .|.||||.  .  .| 
qnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGe

FQVTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHG-VPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEG
....| . |. |.| .|.....  . .|. ..|.||..  |...| |....| || .........|   ...|||||..|||...|. ..| | | . ||
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteG

IVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTT
..|.|. .. .|  .  .|||..|| |. ...|| . . .| 
viDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
Y_phosphatase Protein-tyrosine phosphatase 415-649 8.9e-77 253.0 Pfam-A 1-235 (235) alignment 
Range on Protein: 415-649
Range on HMM: 1-235/235.0
NLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGS
|. | | |. || .. || |. .. .|||| |.||.||.. ..|||||||.|.| .|||||||. |. .|.|||. ||.|.|.  |||| . .|. .||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

FNVVAL-PEERALPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKA
..|     |...  .|..||..|...|.....|......| |||  ..|....|..||. .| . . .. .||..||||.| ||||||.|. ..||.|.|
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
|. .||...||.|| |||| |....||.|..|| ||
eeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 415-649 8.9e-77 253.0 In-house 1-235 (235) alignment 
Range on Protein: 415-649
Range on HMM: 1-235/235.0
NLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGS
|. | | |. || .. || |. .. .|||| |.||.||.. ..|||||||.|.| .|||||||. |. .|.|||. ||.|.|.  |||| . .|. .||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

FNVVAL-PEERALPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKA
..|     |...  .|..||..|...|.....|......| |||  ..|....|..||. .| . . .. .||..||||.| ||||||.|. ..||.|.|
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
|. .||...||.|| |||| |....||.|..|| ||
eeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 82-358 9.2e-77 252.8 In-house 3-284 (290) alignment 
Range on Protein: 82-358
Range on HMM: 3-284/290.0
NVSDFIEMMALLQSNNSDRLEEEYPDIEL-EWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGNP---GSDYINASFIGGLNSPKDYIATQGPIPA
.|..| |..|  .... .. ....  ..  | ..| . .  . |. .||. ||..||  |.||.| ..      .||||..| | .  |.|||||||.. 
pvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn

AFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHG-VPQYATPLL
   |||..||. .|. |.|.|| .|..| ||.||||. ....|| |...| . ||. .| .|...... . .|. ..| ||..  |...| |....| ||
tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill

SFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIM
..........|   ...|||||..|||...|....| | |   || .|.|. .. .| ..  .|||. || .... .|... 
vieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Ptp69D_pd Subfamily Ptp69D 382-653 9.7e-77 253.1 In-house 16-288 (307) alignment 
Range on Protein: 382-653
Range on HMM: 16-288/307.0
SSGKT--GFQSQFETLESSsptDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVW
. ..|  |..  .|.||..     | ......  .|. | | ..  . ...||.|.. |   ||||| ||.. ||...  ||| |.|. .|.||||||..
rkrdtdfglakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmia

EMKSMIIIMLTNTEENGEEQSVQYWPVNpnEEDMYGSFNVVALpEERALPDYIVRKFKLSHSK----NPDDSRTITHFQYINWPSTSCPKEATSMIDLVA
| .. .|.||.| .|  ...  .|||..  .|  ||. .|    .|.  .||| |....|. |    . .||| .. ..| .|. .  |. |.....|. 
eqevtlivmlsnlteknrkkcakYWpie..devqygdilvklv.seekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklie

DVVRIQRKSgNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
 |  ..... ..||.|||| | ||.|.| |.  .|..||||. .|.| ||| || ||. .|. ..||.|...| |.. . 
qvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPRA_pd Subfamily PTPRA 404-651 1.5e-76 252.4 In-house 47-295 (330) alignment 
Range on Protein: 404-651
Range on HMM: 47-295/330.0
DFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQY
.  . .|.  .|  |.|| . || .  ||.||.|.   .|||| ||..|||...  |||.||| ..|  |||||.|| ||. |.|||. .|  ||.  ||
qatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy

WPVNPNeeDMYGSFNVvALPEERALPDYIVRKFKLS---HSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKSGNgPITVHCSDGLGRT
|| .      ||  .| .. .|  | || |||| .    .... ..|| .. | .  ||    | |.  |..|.. | .....|.. ||.|||| | |||
wPdeGl..vtyGnirv.evedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrt

GTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|||... .||||.|||...||| .|| || |||  |.   |||||.|. ||. 
Gtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 118-356 5.2e-76 249.9 In-house 1-239 (239) alignment 
Range on Protein: 118-356
Range on HMM: 1-239/239.0
AAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLN-SPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSf
|||  .|. |||| ||. |||||| |.    .| |||||||..   . ||| |||||| . ..  |||||.|.     |.|.| | |  | |||||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.

GAANYGSFQVTLKEVETVADYAIRTFQLqSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIM
 ...|  ..|||.. | .||| |||| . |  ||   . | |||| ||||.||||||| .| ..... .       | |.||||||||||.|. ||.|. 
stskycnlrvtlrktevfadyiirtfvm.sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

KIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEA
.   .  |||||.|. .|  | .||||. || |.| |.|||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_PTPN9_pd Subfamily PTPN9 88-356 1.2e-75 249.3 In-house 5-289 (297) alignment 
Range on Protein: 88-356
Range on HMM: 5-289/297.0
EMMALLQSNNSDRLEEEYPDIELEW-NFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRM
|..| .....   | .|| .|  |  . | .|.||. |  |||| ... ||..||.|.  |... ||||||.|. | . .| .||||||.. .. |||||
elvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrm

IWEYNVPTIIMVTNLKEDDKIKCHQYWP--SFGAANYGSFQVTLKEVETVADYAIRTFQLQSLHgQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVR
.|| .| .|.|.| . |  ..|| ||||  .  .|..|...|.  |||.  || .|.....  . .. ...|  . || |||.|||. |. || . . ||
vWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvr

NH-----------HKGKP--GPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEA
..           .||.|   |.|||||||.||||||||.|  . ... .| ||... |. .|  | ...||  || | . |.|| 
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 118-355 1.6e-75 248.4 In-house 2-239 (239) alignment 
Range on Protein: 118-355
Range on HMM: 2-239/239.0
AAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGLN-SPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSf
|||  .|. |||| ||. |||||| |.    .| |||||||..   . ||| |||||| . ..  |||||.|.     |.|.| | |  | |||||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.

GAANYGSFQVTLKEVETVADYAIRTFQLqSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIM
 ...|  ..|||.. | .||| |||| . |  ||   . | |||| ||||.||||||| .| ..... .       | |.||||||||||.|. ||.|. 
stskycnlrvtlrktevfadyiirtfvm.sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

KIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILE
.   .  |||||.|. .|  | .||||. || |.| |.||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 124-355 4.6e-74 243.6 In-house 3-237 (237) alignment 
Range on Protein: 124-355
Range on HMM: 3-237/237.0
NHGKNRYVNIIPYDHSRVTLKPDGNpGSDYINASFIGGLN-SPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFG-AANYG
|. |||| ||. |||||| ||  |. |||||||... |.. .|| |||.|||. ..  |||.|.|. .   |.|.| | | ...|||.||||    | ||
nkiknrygnivaydhsrvvlkgags.gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

SFQVTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRN--HHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDA
 . |.||  |  .||..|.. |.  . .  .. . ||.| .|||.||||... || |.|.. |  .|  . || ..|||||||||| |. ||.|. .   
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

EGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILE
. .|||.|.|  .   | |..||  || |.|..|||
kkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0040439 (Phosphotyrosine protein) phosphatases II 406-651 1.1e-73 243.2 In-house 2-246 (249) alignment 
Range on Protein: 406-651
Range on HMM: 2-246/249.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWP
..|.|.|  |. | | . .||..  ||.||  .  ..||||.|||.|||..  .|||||||...| .|||||.|| .. .|.|||...|.| |.  ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

VnpNEEDMYGSFNVVALPEERaLPDYIVRKFKLSHSkNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKS-GNGPITVHCSDGLGRTGTFC
   ...  || | |  | .|  ..||.||...|...   ..|||..|.||..|| ...|.   ...|..  |  ....   .||. ||||.|.||||||.
l..ggsleygdftvtllsvev.kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

AMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|....||.|. |. .|....||.|| |||| |   .||.|...|.||..
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 111-393 5.1e-73 241.0 In-house 35-324 (325) alignment 
Range on Protein: 111-393
Range on HMM: 35-324/325.0
EWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDG-NPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNvPTIIMVTNLKEDDKIKCH
.   .  .| .| |  |||. |....|.||| |.  . .| |||||||..      . ..|.| | .|.  |.||.. ...  ....|.|  . .| .| 
ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrca

QYWPSF--GAANYGSFQVTLKEVETVADYAIRTFQLQSLHGqGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKG------KPGPMVVHCSAGV
.|||     . ..|...| |. .|...||  | ....  .. |  . |.|...  |.| ||... . |.|. . | . ..         .|..|||||||
vywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk.GetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGv

GRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIATLKEIAPSSGKTGFQSQFE
||||.||.. ... |.  |  ||||.||. .|  |  ||.|. || ....|. ||.|. .| .|   . .|...|.|  | . |   . .||
GrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqklniekefe
subfamily_PTPRK_pd Subfamily PTPRK 383-649 7.2e-73 240.2 In-house 19-275 (314) alignment 
Range on Protein: 383-649
Range on HMM: 19-275/314.0
SGKTGFQSQFETLESSsptdddfdCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMK
.   ||. ..|.|              |.  .| .|.|... |...  ||.| | . |  |||| |...|.|.. .|||.||||...|  ||||.|.. .
aegygfkeeyeslfeg........wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvyden

SMIIIMLTNTEENGEEQSVQYWPvnpNEEDMYGSFNVVALpEERALPDYIVRKFKLSH-SKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQ
.  |.|||.  |.|  . ..|||   .. ..|| ..|  . |  .| ...|| |.... ... .. |.. .||...||.   |..||....||. |   |
casivmltelvevgrvkClkyWP...edtevygdikvelv.etellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksq

RKsGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
 . ..|.| |||| | ||||||.|. .||. .. |.|.||| .||||| ... .|.  .|| ||. ..||
ee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPRG_pd Subfamily PTPRG 382-654 8.3e-73 240.5 In-house 15-290 (563) alignment 
Range on Protein: 382-654
Range on HMM: 15-290/563.0
SSGKTGFQSQFETLESSSpTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN-YD--SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWE
..|..||. .|| |.| . ...|.|.. .|  .|  | |  . .. .  || ||     .   ||| |.|.|||..  ||||||||.|.|. |||||.||
adgdigfseefealqset.iskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWe

MKSMIIIMLTNTEENGEEQSVQYWPVnpNEEDMYGSFNVVaLPEERALPDYIVRKFKLSH-----SKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVA
 .. ||.|.|| .|.| ..  .|||   .|   ||...|  | ||  |  | ||.... .      |. |. .......| .|| .. |. ..  .  | 
qnvaiivmitnlvergrrkcdvYWPk..desetygalqvt.lieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk

DVVRIqRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
   .  .|.  |||.|||| | |||||.... |.|.....|....|| ..|..| ||.  |....|| |.|.| || ... 
kssaa.nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
0042113 (Phosphotyrosine protein) phosphatases II 407-651 3.7e-72 238.0 In-house 1-243 (245) alignment 
Range on Protein: 407-651
Range on HMM: 1-243/245.0
CSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPV
.|.|.|  |  | | .. || .. ||.||  ..|  |||| ||||||||.   |||||||...| .|||||.|| .. .|.|||..||.| ... |||| 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

npNEEDMYGSFNVVALPEERaLPDYIVRKFKLSHsKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAM
  .|.  || | |  | ||  |.||.||...... .  | ||...|..|..||  ..|    ...|..  | .......|||. ||||.|.||||||.|.
..gesltygdftvtllseeh.lddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

FTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
...||.|..|. ......|| || |||| |   .||.|...|.||..
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 379-651 4.8e-72 237.4 In-house 14-279 (288) alignment 
Range on Protein: 379-651
Range on HMM: 14-279/288.0
IAPSSGKTGFQSQFETLessSPTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLST--KNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMV
..  ...|||......|   .. . . . ....|. |  | | .. || .  || |    .. ..||| |||.||.... ..||||||. .| .|||..|
kksarnrtgfseeynsL...aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WEMKSMIIIMLTNTEENGEEQSVQYWPVNpNEEDMYGSFNVVaLPEERALPDYIVRKFKLShskNPDDSRTITHFQYINWPSTSCPKEATSMIDLVAdVV
.| |.  |.|||.  |.|...  .||| . ...  |||..|. | |.. | |...||. |       . ..||..||  || .. |. .. ...|.   |
yenktstivmltelveggktkCeeYWPda.dkpknyGsvtvt.lveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellr.qv

RIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
 .. ..  |||.||||.|.|||||| |. ........|..|||..||. || ||. .|.   |||||... |. .
kvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 97-355 1.2e-71 236.0 In-house 3-266 (274) alignment 
Range on Protein: 97-355
Range on HMM: 3-266/274.0
NSDRLEEEYPDIELewNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDG--NPGSDYINASFIGGLN-SPKDYIATQGPIPAAFPDFWRMIWEYNVPT
..  ||.|. .. |  ||.    ... .. |||| .|.| ..|||.|...   .. |.|||| .| | .   | |.|||||.| .  ||||||.. .|. 
sfkdlekeflelPl..nfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqv

IIMVTNLKEDDKIKCHQYWPSFGAA----NYGSFQVTLKEVETVADYAIRTFQLQSLHGqgpIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRN---HH
|.|.|.||| .. ||..|.|    .    .|| .... ... .  || .|.. |..|.     ..|  | .  |||| .|. |..||.. . |..   ..
ivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreee

KGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILE
. | .|.|||||||.|||| ||.|.  . ....|..||... |  .|  |  ||||..||...|.|. .
naklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPN6_pd Subfamily PTPN6 366-654 1.2e-71 236.2 In-house 6-300 (306) alignment 
Range on Protein: 366-654
Range on HMM: 6-300/306.0
AVHMATKIATLKEIAPSSGKTGFQSQFETLESSSpTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL-STKNYDSDYICASYVDGYRQ--RSAFIATQ
| ..  ..  |..   | .|.||. .||.|. .  . . .. . ..  .|  | | |  || .. ||.| . . ..|||| |.|...  .  . ..||||
akeieqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatq

GPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDmYGSFNVVALPEeRALPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCP
| ...|  |||||||. .| .|.|.|.  | |.|. ..||| . ..|. ||. .|  . | ..| |||.|....|. |. ...|.. .... .||  ..|
gclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvp

KEATSMIDLVADVVRIQRKSG---NGPITVHCSDGLGRTGTFCAMFTVLERLK---AEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTF
|.   ..|.. || | |...    .||| ||||.|.||||||  . ..|. ..    .  ||. ..||..| || |.|.  .|| |..||  ....| 
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_PTPN3_pd Subfamily PTPN3 115-358 4.4e-71 234.1 In-house 32-276 (280) alignment 
Range on Protein: 115-358
Range on HMM: 32-276/280.0
TSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGNpgsDYINASFIG----GLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQ
.  ||..| |  |||| .|.|||. ||.||   .   |||||...     . .  . |||||||.. .  |||.|.|| .. .|.|.|.| |. ..||||
aisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPSFG-AANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGpIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFIT
|||. .   .||.|.|.... ..   |..| . |.  . .   ... |  .| |||||||. .. .|.| .|||. ..||  |.|||||||.|||| .|.
yWPetedeleygefsvkcekedetksyvlrelvlkdketke.erkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlil

IDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIM
..| ...|.|.  | . . || ||  |  .||||||| |. .|||.. .
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
0045098 (Phosphotyrosine protein) phosphatases II 405-655 9.9e-71 233.7 In-house 23-276 (278) alignment 
Range on Protein: 405-655
Range on HMM: 23-276/278.0
FDCSIAQLSDNLAKSRVKEHLPPNDYRVVlstknydsDYICASYVDGYrqRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPv
 ... |.. .||.| | |. || .  ||.        ||| |||.|||  . .|||||||...|. |||||.||... .|.|||. .|.| |  .|||| 
seitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.

NpNEEDMYGSFNVVALPEERAlPDYIVRKFKLSHS---KNPDDSRTITHFQYINWPSTSCPKEA--TSMIDLVADVVRIQR------------KSGNGPI
. ..   || | |  | ||.  .||..|.... .    .. . ||..||..|..||  ..| .   .|...|.  . . ..             ...||.
e.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

TVHCSDGLGRTGTFCAMFTVLERLkaEQVIDVFSTVKTLRIQRPG-FVNDIDQYEFIHKAALEFVNTFD
 |||| |.|||||..|....||.|  |...|....||.|| ||||  |   .||.|.....||... ..
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_PTPRB_pd Subfamily PTPRB 384-652 1.2e-70 232.8 In-house 23-286 (293) alignment 
Range on Protein: 384-652
Range on HMM: 23-286/293.0
GKTGFQSQFETLESsspTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKS
 ...|. ..|.|..    . |  ...|.|. | || | .. || .  || |   ... .|||| |.|..||...  |||||||. .|  |||||||| ||
sdlrfseeyeelka...vgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekks

MIIIMLTNTEENGEEQSVQYWPVNPNEEdMYGSFNVVaLPEERALPDYIVRKFKLSHsknPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVR-IQR
 ||.|||.. |.| ..  .||| . ..  .||. .|  | .|. | |...|..|...    ...|........ ||    |.......|.|  | . |..
siivmltqlvekgkvkCeeYWPadeepv.lyGdikvt.lvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek

KSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
.. ..||.|||| |.|||||| |. ..|.... |...|.|..|  || .|  .|   .|| |||.. |....
taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN9_pd Subfamily PTPN9 373-652 1.4e-69 229.4 In-house 3-291 (297) alignment 
Range on Protein: 373-652
Range on HMM: 3-291/297.0
IATLKEIAPSSGKTGFQSQFETLESSSPTdDDFDCSiaQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQRSAFIATQGPMKNTAG
|  | .   . || | . ... . . ...   |..|  .|  || | | .. |  .. ||||.... |  |||| |..||||.|. ||||||||.|.|  
ieelvayvkekgkrGlskeyaeirnepve.Gtflas..klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

DFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALPEErALPDYIVRKFKLSHSKNpDDSRTITHFQYINWPSTSCPKEATSMID
|||||||| . ..|.| | ..|.|  .  |||| . .. . .|...|  .  |    || ||.......|. ..||..||||.. ||    |..|.|..|
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveve.eeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslld

LVADVVRIQRK------------SGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
..  | . | .              . || |||| |.||||||...   |.||. ....||. |||.|| ||   .   .|||| ..| ||.  
vlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 98-398 3.4e-69 228.1 In-house 19-277 (392) alignment 
Range on Protein: 98-398
Range on HMM: 19-277/392.0
SDRLEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTL-KPDGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIM
|  . ||. |.     .   .|. .||  |||| ||.||| .|| |   |  | |||.|||.| .... | |||.||| .|.. |||||... || ||.|
salffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiam

VTNLKEDDkikchqywpsfgaanygsfqvtlkevetvadyairtfqlqslHGQgPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVH
||.||| |                                          .|.   . | |.||  |||..||.... || | | |. ..     |...|
vtklkegd..........................................kgd.dartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliih

CSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKIATLKEIAPSSGKTGFQSQFETLE
|||||||||  |.||... .     .||.||||  .|  | |||||  || |.. |.|| .. |.| || ||.. ....|.  .   ...  . .|..| 
csagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdvrskqlkefrslk

SS
.|
as
subfamily_PTPN13_pd Subfamily PTPN13 98-357 1e-67 223.3 In-house 10-269 (273) alignment 
Range on Protein: 98-357
Range on HMM: 10-269/273.0
SDRLEEEYPDI-ELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGNpgsdYINASFIGGLN--SPKDYIATQGPIPAAFPDFWRMIWEYNVPTI
..  .||. .. ||    |.  .|   |. |||| |..|||..||.|. .|.    |||||.|         .|||.|||.| .  |||.|.|| ..  |
qqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevi

IMVTNLKEDDKIKCHQYWPSFGAA---NYGSFQVTLKEVETVADYAIRTFQLQSLHGqGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKgKPG
.|||. ||..|.|||.|||.        .. ..|.| .|.   ....|..... ..  |  .|| . .|  |||||||. |..|| | ..||. .. . |
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dag

PMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
|.|||||||.||.||.||||...  |. .  .|. . || .|  |. .|||  || | ..||||..
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
0037934 (Phosphotyrosine protein) phosphatases II 406-650 1.8e-66 219.5 In-house 1-241 (243) alignment 
Range on Protein: 406-650
Range on HMM: 1-241/243.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLstknYDSDYICASYVDGYRQrsaFIATQGPMKNTAGD----FWRMVWEMKSMIIIMLTNTEENGEEQSVQY
..|||.|  || | |..  || .. ||.|     .||||.|........   .||||||...|  |    ||||.|| .. .|.|||...|.| |. .||
sfsiallpenlsknrysdilpydhsrvkl....egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPvnpNEEdMYGSFNVVALPEERaLPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRK-------SGNGPITVHCSDG
||   .|. .|| | |  | ||  |.||.||...|.. . .| .|...|..|..||  ..| . ....|.. .|  ....       ...||. |||| |
wp...gev.tygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

LGRTGTFCAMFTVLERLkaeQvIDVFSTVKTLRIQRPG-FVNDIDQYEFIHKAALEF
.|||||..|....|..|   . .|....||.|| ||||  |   .||.|...|.||.
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN12_pd Subfamily PTPN12 384-652 7.3e-66 217.0 In-house 6-278 (290) alignment 
Range on Protein: 384-652
Range on HMM: 6-278/290.0
GKTGFQSQFETLESSSP---TDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWE
|.  |...|..| . |    ... .  . .. . | .| | |. || .  ||.||...   .|||| |... |  .. ..||.|||. .|  |||||.||
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwe

MKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALPEERALPDYIVRKFKLSHSknpDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRI
..  |..|. .  |.|  .  .||| . .|| ..|.|.|    |..   |...| .|. ..   ..||... |.| .||   .|. |.|...|...| ..
knveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrel

QRkSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQV---IDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
|. | . |. |||| | ||||| .|.  | | ||||..   .|||. | .|| ||.  |   .|||...|| .|.|.
qe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN1_pd Subfamily PTPN1 103-361 1.1e-65 216.2 In-house 10-277 (290) alignment 
Range on Protein: 103-361
Range on HMM: 10-277/290.0
EEYPDIELEWN-FTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGNpgsDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLK
| | ||. | . |.  .|||| |...||| .. ||||||..|. . |   ||||||..   .  . || ||||.| .   ||.|.|| .  ...|. .. 
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvv

EDDKIKCHQYWPSFGA---A--NYGSFQVTLKEVETVADYAIRTFQLQSLHGQGpIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHH--KGKPGPMV
| ..|||.||||.         .  ...|.| . |.   | .|...|. |. |   .|. ..|.. ||| |||.  . .|.|  .||.    . . || |
ekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqe.treilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpav

VHCSAGVGRTGTFITIDTMIMKIDAEGI---VDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIM--CRD
.|||||.||.|||. .||....|....    ||| . .  .|  |  ..||| | .| . |||| .    .|
ihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgd
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 383-657 2.7e-65 215.0 In-house 12-299 (301) alignment 
Range on Protein: 383-657
Range on HMM: 12-299/301.0
SGKTGFQSQFETLESSSptddDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNY----DSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWE
  ...|..|...|.. .    |  |..   ..| | .| |.  . .| |..|..|.       .|| |||.|||... .|||.|||||.|  ||||..|.
khsnkfeeqykelkege....dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

MKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVvALPEERALPDYIVRKFKL--------------SHSKNPDDSRTITHFQYINWPSTSCPKE
 | . |.|.||..|. .... ||||   .|.. .| |.|  | .| ..||...|....               . |.  .|.... .| ..||     .|
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftv.tlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

ATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDNY
   ..  . ||.  |.| | ||. |||||. .|.|..|..   ||  ||| |.|||  .|..| ..|| |  ..|| .|...  ....  . |
prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 124-373 1.4e-64 212.7 In-house 33-282 (283) alignment 
Range on Protein: 124-373
Range on HMM: 33-282/283.0
NHGKNRYVNIIPYDHSRVTLKPDGNpgsDYINASFIG---GLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANY
|. |||. .|.|.|  || ||.. .   |||||.||      .  |.||..|.|.  .  |||.|... .. .|.|.|.|.|| .||| ||||. |. .|
nkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy

GSFQVTLKEVETVADYAIRTFQLQSL-HGQGPIKeVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDA
| | |||..  |   . |. . |.     .  .  .  | .  | . |       |. | | . .  . | ||.|||||.|.|||..||.. . . .. .
Geftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdalt

EGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIPAVHMATKI
| .||.|. |. ||  |  .|||  || ..|...||  .| || | || . . |
esvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqsti
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 384-651 4.7e-63 208.0 In-house 22-279 (315) alignment 
Range on Protein: 384-651
Range on HMM: 22-279/315.0
GKTGFQSQFEtlesSSPTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKS
 | ||. ..|    | |  . .   .|. . |  | |  . .. .  || |    .. .|||. |...||| ..  .||.|||  .. .||||.|.| . 
tkngfkqdye....sipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedi

MIIIMLTNTEENGEEQSVQYWPVNpneEDMYGSFNVVALPEErALPDYIVRKFklsHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRK
  |.||||. |. .... .||| .   . .|| . |    ||    .| || .        |. |..  ..|  || .  || ......|.  | . . .
gkivmltnlvegekrkaekywpdk...kviyGkitvtrksee.vnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtn

SGnGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|  |.| ||||.| ||||||... .||....||..|||.  .. .| .| . |. ..||.||..| || .
sv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 411-652 8.3e-63 207.0 In-house 24-269 (274) alignment 
Range on Protein: 411-652
Range on HMM: 24-269/274.0
QLSDNLAKSRVKEHLPPNDYRVVLSTKN---YDSDYICASYVDGYRQR-SAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNP
... .  | | |. || .  ||.|....    ||.|| | |. ||...  |..|||||. ||  |||||... .. .|.|||. .|. |.. ..|.| . 
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

NE--EDMYGSFNVVaLPEERALPDYIVRKFKLSHSKNpddSRTITHFQYINWPSTSCPKEATSMIDLVADVVRI--QRKSGNGPITVHCSDGLGRTGTFC
.   .. || ...    .     || |||. |.....   .|...|. | .|| .  |..|....|||..| .   ...   .|. |||| |.|||| | 
dyeiserygdveik.vekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi

AMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
|.   . .|..|.|.||...|  ||..| | |.  .|||.||.|  ....
aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 406-649 2.9e-62 205.8 In-house 52-289 (319) alignment 
Range on Protein: 406-649
Range on HMM: 52-289/319.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTnteengEEQSVQYWP
| . | | .|  | |. . |. .  .| |   .    |||| ||.|.||...  .||.|||..||  |||||.||...  |..||      ...  ||||
dqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

VNPNEEDMYGSFNVVALPEERAlpdYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRK-SGNGPITVHCSDGLGRTGTFC
 . ....  .  .| .. |      |.||...||.  .  | | || | .  ||    |. .. .. ||  |  ...|  .. .| |||| | ||||.. 
lkivikeerfkvkvdsveetae...yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyi

AMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
.. ..|.|.| |. .||. .|. || ||. .|.|. || ||. | ||
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN23_pd Subfamily PTPN23 123-357 1.6e-61 202.6 In-house 42-280 (288) alignment 
Range on Protein: 123-357
Range on HMM: 42-280/288.0
INHGKNRYVNIIPYDHSRVTLKpdgNPGSDYINASFIGGLNSP-KDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSF-G-AAN
..  |||. .|.||||.||.|.   .   |||||||. .| .   |.||||.|.. .  |||.|..|  ...|.|... .| .| |...|||.  | . .
lyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

YGSFQVTLKEVETVADYAIRTFQLQSlHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHK----GKPGPMVVHCSAGVGRTGTFITIDTMIM
.| ..||||.|..   .  |...|.  ...  .|.|.  ..  ||..|||.    || | . |.....        |.||||||||||||.|  . . . 
fgdlsvtlksvretethvervlklet.ldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

KIDA-EGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
.... .|..|| . |. .|  | .|||. .|. |. .|.|||.
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 385-650 1.8e-61 202.5 In-house 5-265 (283) alignment 
Range on Protein: 385-650
Range on HMM: 5-265/283.0
KTGFQSQFETLESSSPTDDDFDCSIAQlsDNLAKSRVKEHLPPNDYRVVLSTKNYdsDYICASYVD---GYRQRSAFIATQGPMKNTAGDFWRMVWEMKS
..... ..|.|.  |  | | |.. |.  .|  | | .| .| . .|| | ...   ||| |...     |.|   .|..|.|...|  |||.||.. | 
vnnnklfrevlkrlsvpdldadiasad..enkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

MIIIMLTNTEENGEEQSVQYWPVNPNEEdmYGSFNvVALPEERALPDYIVRKFKLSHSKNPDDSRTITHFQYINWpsTSCPKEA--TSMIDlVADVVRIQ
  |.|||.  |. ...  |||| .  |.  || |  |.| .| .   .|.... | ..    ..  ..|.|.|.|  ... ..|   |..  .  |.  |
taivmltklqedlrikCsqyWPkrGsed..yGeft.vtlrkettsnsfiikelllrvnssakstlllahyqvidW..leygeqaiinslvk.fnkvislq

RKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
..| .||| |||| | |||..|.|. . .. ...| |.|||..|| .| ||.. |   ||| ..|...|| 
teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 406-649 1.8e-61 203.1 In-house 16-253 (284) alignment 
Range on Protein: 406-649
Range on HMM: 16-253/284.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTK--NYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTnteengEEQSVQYWP
| . | | .|  | |. . |. .  .| |     .  |||| ||.. ||...  .||||||..||  |||||.||...  |..||      ...  ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

VNPNEEDMYGSFNVVALPEERAlpdYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRK-SGNGPITVHCSDGLGRTGTFC
 . ....  .  .| .. |      |.||...||.  .  | |.|. | .  ||    |. .. .. ||  |  ...|  .. .| |||| | ||||.. 
lkivikeerfkvkvdsveesee...yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

AMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
.. ..|.|.| |. .||. .|. || ||. .|.|. || ||. | ||
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 383-653 2.6e-61 202.2 In-house 12-278 (281) alignment 
Range on Protein: 383-653
Range on HMM: 12-278/281.0
SGKTGFQSQFETLESSsptDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMK
. ..||....|.|..    . |   . ..  .|  | | .     .  ||..  . .| ..||| |..|.||..  ..||||||. ..  .||.|||| |
ndnaGfieeyeklaai...gvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

SMIIIMLTNTEENGEEQSVQYWPvNPNEEDMYGSFNVVALPEeRALPDYIVRKFKLshSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQR
  .|.|.|.  |.|  .  .||| ..|.|  || . |  . | .. . || |||||  ...  ..|......|..|| .  |.... ...  ..| ....
vsaivmvtreieagklkChrYWP.ddnselkygdvtvkstae.eekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlklte

KSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAE-QVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
|. . |. .||| | |||||. |. .......|| . .||  .|. || .|  .|  . ||||..|| |. .. 
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPRN_pd Subfamily PTPRN 96-356 1.5e-60 199.5 In-house 26-291 (297) alignment 
Range on Protein: 96-356
Range on HMM: 26-291/297.0
NNSDRLEEEYPDIELEW--NFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGNP-GSDYINASFIGGLNSP-KDYIATQGPIPAAFPDFWRMIWEYNV
.| ||||.|.  .      . |. .|| . |  |||. ...|||||||.|| . .   |||||||.|   .     |||||||...   |||.|.||  |
knkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

PTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLK-EVETVADYAIRTFQLQSLHGQGpIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKP
  |...|.|.|..  .|..|||  |.. |. ..| |  |     || .|.| |. |. .   . | |.||| ||..|||  | .|| |...|   ..|. 
vvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse.trtvtqfhflswpeegvPasaksllefrrkvnksyrGrs

GPMVVHCSAGVGRTGTFITIDTMIMKIdAEGI--VDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEA
 |.|||||.|.||||..| || .. .. . |.  .||   .  .|  |. .|.| .|..|   |. | 
cpivvhcsdGaGrtGvyilidlvlnrl.lkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_PTPN3_pd Subfamily PTPN3 402-649 2.4e-60 198.8 In-house 28-273 (280) alignment 
Range on Protein: 402-649
Range on HMM: 28-273/280.0
DDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYdsDYICASYVD----GYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQ
. . ..|.|....||.| | .. || .. || |.  .   ||| |.||.    .  .   .||||||...|| |||.|||| || .|.|||.. |.|  .
kpglaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

SVQYWPVnPNEEDMYGSFNVVALPEeRALPDYIVRKFKLSHsKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADvVRIQRKSGNGPITVHCSDGLGR
  ||||  ...|  ||.|.|.   | ..   |..|.. |.. |. ...|.|...||..||  . |.........|   || .|.. . |. |||| |.||
ChqyWPe.tedeleygefsvkceke.detksyvlrelvlkd.ketkeerkilqlqylaWpdhgvPddsadflefver.vrklrsgkeePvvvhCsaGigr

TGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
|| . .. | |  . |.. . .   |.|.| ||  .|.  .||.|. .| |.
tGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_PTPN14_pd Subfamily PTPN14 113-357 3.1e-60 198.7 In-house 38-296 (300) alignment 
Range on Protein: 113-357
Range on HMM: 38-296/300.0
NFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGNPGSDYINASFIGGLNS--PKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQ
. . ..|||| |  |||. ...||...|| |.|  .  ..||||| |    .   ..||..|||.. .  |||.|.|| .|  |.|.|. .|| | |...
dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWPSF----GAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQgPIKEVRQYHFLVWPDHGVPQYATPLLSFQKR---VRNHHKGKP------GPMVVHC
|.|.       ...| |.|| | .|.   .. ....|. |  .   ..|    .  |||||||.  .. ||. ..   ||.. . .        |..|||
yfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk.eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhC

SAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
||||||||  |. | .|  .. .  .|| . .. .|  | ..||| .|| |....... .
saGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 124-358 1.1e-58 193.3 In-house 20-265 (270) alignment 
Range on Protein: 124-358
Range on HMM: 20-265/270.0
NHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGL-NSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAA---
..  ||| .|.|  ..||.|.. . .. . |||| .. |  ...| |||..|| |..  .||||||| .|..|.|.|.|.|. . || .|||.       
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-NYGSFQVTLKEVETVADYAIRTFQLQslhGQGPIKEVRQYHFLVWPDHGVPQYAT------PLLSFQKRVRNHHKGK--PGPMVVHCSAGVGRTGTFIT
 ..|  .|.  . |    | ..  .|.    .| ....  ...  |||||||. .        ||.  . ||...| .   .|..||||||||||||.|.
ledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIM
.|...  .. .. ||. . .. .|  |  .||.  || ||..|..| . 
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_PTPN23_pd Subfamily PTPN23 382-653 1.8e-58 192.6 In-house 11-282 (288) alignment 
Range on Protein: 382-653
Range on HMM: 11-282/288.0
SSGKTGFQSQFETLESSSPTDdDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLStkNYDSDYICASYVDGYRQRS-AFIATQGPMKNTAGDFWRMVWEMK
 .|||... .|. ||..   .   . |||    .  | | .. || .  ||.|   .   ||| ||.| .    .  |||||.|...|..|||.||.| |
ldgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

SMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNvVALPEERALPDYIVRKFKLSHSkNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVR---
| .|.||.. || |...  .||| . .|   .| .. |.| ..| .. .. |..||..  ..|  ....| |. .||.   |.   ......  |     
ssviVmllskeelgkpkvdrYwPedkgetvkfgdls.vtlksvretethvervlkletl.dadavksvshlqltsWpelGvPasPetllqfldevesaye

IQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQ-VIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
 ...  . |. |||| | ||||.|. ...... |.... ..|.   |..|| ||   |.. .|..|  .| || .. 
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_CG7180_pd Subfamily CG7180 388-656 2.1e-58 192.3 In-house 15-295 (296) alignment 
Range on Protein: 388-656
Range on HMM: 15-295/296.0
FQSQFETLESSSPTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTK--NYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIII
|. ... .    |. .  ||  .  ..|. | |  . .|..  ||||..   . .|||| |.|||.. .  ..| |..|.|.| ..|||.|.. ..  ..
frveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavv

MLTNTEENGEeQSVQYWPVNPneEDMYGSFNvVALPEERALPDYIVRKFKLSHS---------KNPDDSRTITHFQYINWPS-TSCPKEATSMIDLVADV
.||.| .  . .  .||| .   .  || .  | . ||. ...   |.||| .          .   . |....||.  |..  ..|  ....|.|.  |
vLtktfdfak.mypsywpnks..keqygeif.veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

VRIQRKS----GNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFDN
  ...|      .||. |..||| .|.| ..|.   || .. |. .|||  |||||..||. |. ...| .|    ||.| .. .
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_PTPN13_pd Subfamily PTPN13 391-653 1.1e-57 190.4 In-house 16-271 (273) alignment 
Range on Protein: 391-653
Range on HMM: 16-271/273.0
QFETLESSSPTDddfDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYdsdYICASYVDGY--RQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLT
.|..|.   |.|   .|....  .| .| | .. || .. || |. .     || ||..      ..  .||.|||. .|. |||.|||| |. .|.|.|
efkelrelkpld...tcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

NTEENGEEQSVQYWPVNPNEEDMYGSFNVVALPEERALPDYIVRKFKLSHSKNpDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRksGNGPIT
.  |.|. .  .|||.. |.. .  .   |.| .   | .. ||......|.   .|| ..|.....||  . |..|.... .|| | |.|.   .||| 
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPiv

VHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
|||| |.||.||. .. .||. .. .. .||  .|..|| || | |   ||| |..||.|| ...
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 401-651 1.2e-57 190.2 In-house 30-277 (315) alignment 
Range on Protein: 401-651
Range on HMM: 30-277/315.0
TDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQS
  | .   .|. ..|  | | |. || .  ||.|    .. ||||| |||. .. .  |.||.||| | .  ||||||.. |   |.|.|. .|.   . 
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc

VQYWPVNPNEEDMYGSFNVVALpEERALPDYIVRKFklsHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVvRIQRKSGNGPITVHCSDGLGRT
 |||| .  .   .||..|  | .  |  | ..||.     .. ..|||.| ||. .||    .|...|.. |. .| . .... . .. |||| | |||
rqywPdrkadsvefGsikvell.sleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikev.kadngkkefsllvhcsaGvGrt

GTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
| ....  |....| ....||| .||.|| .|| .|.  ..| ||. | || .
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 399-651 1.5e-57 190.2 In-house 32-288 (325) alignment 
Range on Protein: 399-651
Range on HMM: 32-288/325.0
SPTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIiIMLTNTEENGEE
 |.||     .| . .| || | |. .. .  |||| ||. |  |||| |||.  ....  |.|.| |. .| .|.||.| . .. . ....|  ..|..
lpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsv.vvvlneldlgkd

QSVQYWPVNPNEEDMYGSFNVVALPEERAlPDYIVRKFKLSHSKNpDDSRTITHFQYINWPSTSCPKEATSMIDLVA---DVV-RIQR-KSGNGPITVHC
.  .||| .  .   .|...|     |    ||. |....   |.  ..|..  ||.  |.    .|  ...| ..     |  |..    . .|| |||
rcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkk.GetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

SDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
|.|.||||.| .....|...  |  .|.|  || || .||  |. .||| .|..|  |..
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_CG7180_pd Subfamily CG7180 124-361 2.1e-57 189.0 In-house 42-294 (296) alignment 
Range on Protein: 124-361
Range on HMM: 42-294/296.0
NHGKNRYVNIIPYDHSRVTLK-PDGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKiKCHQYWPSFGAANYGS
| .|||.|...|||. || |.  ||.  ||||||... ..  .|.|| |..|   .  .|||.... .. .....|.  .  | ....|||  . ..|| 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

FQVTLKEVETVADYAIRTFQLQSL---------HGQGPIKEVRQYHFLVWPD-HGVPQYATPLLSFQKRVRNHHKGK-----PGPMVVHCSAGVGRTGTF
. | . |... |.  ||||.|.           . . . . |..... .|.  . ||  .. |. . .|||   .        ||.||..| |..|.| .
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

ITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRD
..||  . ... |. ||.|..|. .|  |. .|..  .| ..   .|||..|  
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 406-651 2.2e-57 189.3 In-house 34-276 (515) alignment 
Range on Protein: 406-651
Range on HMM: 34-276/515.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWP
  ..||   |  | | |. || .  || |     | .|||. |||. ..    |.||.||| | .  ||||.|.. .   |.|.|. .|.   .  .|||
pqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

VNPNEEDMYGSFNVVALPEErALPDYIVRKFKLShsKNpDDSRTITHFQYINWPSTSCPKEATSMIDLVADVvRIQRKSGNGPITVHCSDGLGRTGTFCA
  | .   .||..|  .  | |  . | ||...   |. |||||.| |.. .||    ||...|.. |. .| . ..   . |. .||| | |||| ...
dkpgdsvkfGsikvelvsle.actggikrkltvl..kg.ddsrtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvis

MFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
.  |. . |  ...||| .|. .| .|| .|   .|| ||. | || .
idsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 85-365 7.6e-57 187.7 In-house 6-287 (439) alignment 
Range on Protein: 85-365
Range on HMM: 6-287/439.0
DFIEMMALLQSNNSDRLEEEYPDIELE-WNFTSYA--AKLPINHGKNRYVNIIPYDHSRVTL-KPDGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFP
.| | .  |. |. . ..|..  |.    ...  |  |    .. |||| .. ..||.|||| .  | | | |||| .| |   .| |||||||   .  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMIWEYNVPTIIMVTNLKEDDKikchqYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGP-IKEVRQYHFLVWPDHGVPQYATPLLSFQ
||||...| .. ||.|.||| |  |     |||| . . ||   |       . .|.|| |..   . ..   . | |.|.. |||. ||  |. .| | 
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

KRVRN-HHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTIP
. .     | . ||.||||||||||||| |..|  . .. .|  |||   |. .|  |. |||.  || |.. |.|| |.  |... 
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavt
0051429 (Phosphotyrosine protein) phosphatases II 149-377 4.5e-56 185.7 In-house 2-244 (272) alignment 
Range on Protein: 149-377
Range on HMM: 2-244/272.0
PGSDYINASFIGGLNS---PKDYIATQGPIPAAFPDFWRMiWEYNVPTIIMVTNLKEDDKIKCHQYWP------------SFGAANYGSFQVTLKEVETV
| |.||||...||...   |. .....|| |.   ||||. .|... ||...... | .. ||..|||            |.   .|| . ||| ..|. 
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

ADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYAtpLLSFQKRVRNhhkgkPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVD--------I
 || .|...|  |.. | . ||...|.. |||||||| |  ||.. . ...     .||..||||||..||||.. .. ... ...| |||        .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FNFVRGMRFCRNYMVQTASQYDFLHHAILEAiMCRDTTIPAVHMATKIATLK
...|. .| .| ..|||  || ||..|.||. ... ....| .... .....
eeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 407-653 4.6e-56 185.1 In-house 43-286 (297) alignment 
Range on Protein: 407-653
Range on HMM: 43-286/297.0
CSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQrsAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEeQSVQYWPV
   |.   |. ||| |  || .  || |   | |  |||. ||.| |...   .|.|| |||.|  |||.||.. .  .|.||.. .|. . .  .||. 
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsd

NPNEEdmYGSFNVVALPEERAlPDYIVRKFKLSHSKnPDDSRTITHFQYINWPSTSCPK--EATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFC
.   .  .|.  || |  ..    .| |.......| .   | .  .|...||. . ..  .|.|...|. .|     .  .||. |||. |.|||| ..
kgvtt..fGdvsvvllsvser.eGfikrelevtkgk.akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

AMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
..  |. . | |. .|.| .|| || .|| .|   .||.|...| ||.. .
tidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 94-363 1.1e-55 183.5 In-house 10-299 (301) alignment 
Range on Protein: 94-363
Range on HMM: 10-299/301.0
QSNNSDRLEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGN---PGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYN
 ...|...||.| ... . . ..       |.  ||. || .||. |..|||  |      .|||||.| | .. | .||.|||.     ||||.||.. 
aakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

VPTIIMVTNLKEDDKIKCHQYWPSFG--AANYGSFQVTLKEVETVADYAIRTFQLQSLHGQG--------------PIKEVRQYHFLVWPDHGV-PQYAT
. .|.|||||||. | ||.||||.      ..| |.|||..  .. |. || ....  .| .                ..| |..   ||..|| ....|
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

PLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTT
 | . .. .   .|   ||.|||||..|.|.|......  .    |||.||.|. .. .|  .  .|.|  || ... .| . ... .| 
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
0041856 (Phosphotyrosine protein) phosphatases II 124-364 5.3e-55 181.1 In-house 1-178 (182) alignment 
Range on Protein: 124-364
Range on HMM: 1-178/182.0
NHGKNRYVNIIPYDHSRvtlkpdgnpGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTnlkeddkikCHQYWPsfgaanygsf
|. ||||..|.||||||         ..|||||... |   ....|||||| .  ..||.||..|... ||...|         ...|||          
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

qvtlkevetvadyairtfqlqslhgQGPIKEVRQYHFLVWPDHGVPQyATPLLSFQKRVRNhhkgKPGPMVVHCSAGVGRTGTFITIDTMIMKidaeGiV
                         .   ... ||..| |||||||     ||.| ..|..    ..|| .||||||||||||.. .. |. .    | |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.v

DIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTI
.... |. .| .|. ||.| .|| ||. |.|| .....|..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_PTPN14_pd Subfamily PTPN14 393-652 6.1e-55 181.3 In-house 27-297 (300) alignment 
Range on Protein: 393-652
Range on HMM: 27-297/300.0
ETLESSSPTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL-STKNYDSDYICASYVDGY--RQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTN
   |  ..   | ..| |.| .|  |.|.|. || .| || | .||. ...|| || .      ..  .|..|||...|  |||.|||| .  .|.|||.
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlte

TEENGEEQSVQYWPVN--PNEEDMYGSFNVVALPEERAlPDYIVRKFKLSHSKNpDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKS-----
.||.| |.|..|.| .   ...  .| |.|..   | . . .| ...|| |     . ||. |.||..||   .|.. ..... . .|  ..||.     
eeedgkeksfkyfPkleskkktvefgkfkvttkfseds.dsvittglklkhlps.keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

---GNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
    . |. ||||.| ||||       ... |. ...||. .....|| ||  .|. . ||.|..|. .....
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPRN_pd Subfamily PTPRN 389-653 6.3e-55 181.0 In-house 32-294 (297) alignment 
Range on Protein: 389-653
Range on HMM: 32-294/297.0
QSQFETLESSspTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVD-GYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIII
. ..|.| .     ..  ...|.  .|. | |.|. || .. || |....   .|||| || .     ...|.||||||. .|  |||.||||  ...|.
ekewealcay..eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MLTNTEENGEEQSVQYWPVNpnEEDMYGSFNVVALPEERALPDYIVRKFKLSHSKNpDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKsGNG
.||. ||.| .|  .||| .   ...|. ..|  . |     ||.|| | |   .. ...||.| | .. ||....| .| |....   | .  |     
nltrleeegvkqckrywpde..Gsevyhiyevhlvsehiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rsc

PITVHCSDGLGRTGTFCAMFTVLERL-KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
|| |||||| ||||.....  ||.|| |  . ||. .|.. || ||||.|.  ||.||. .|  | ||.
pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevna
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 117-354 1.5e-54 179.8 In-house 31-274 (287) alignment 
Range on Protein: 117-354
Range on HMM: 31-274/287.0
YAAKLPINHGKNRYVNIIPYDHSRVTLKPDGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFG
 ||.   .  |||| ...|.|..|| |  .|. ||||||| .. . .  . .||.||||.|.  ||||...| .. ..|..|   |. . ||..|||   
kaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

A-ANYGSFQVTLKEVE-TVADYAIRTFQLQSLHGQGpIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHH-----KGKPGPMVVHCSAGVGRTGTFIT
     | . |.| . .    .|..|...|  |...   . |.|...| |||....  |  |. |   |..|        . ||.|||...|.||.|....
vPmrvGGysvvlldydikePeygvralrlidletre.arvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

IDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAIL
. ... .    | ||. . |  .|  |. .||.. |. .|  |. 
tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 388-653 2.6e-54 179.0 In-house 12-279 (287) alignment 
Range on Protein: 388-653
Range on HMM: 12-279/287.0
FQSQFETLESSSpTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLS-TKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIM
 . ....|   |     .    |.   .  | |  . || .| ||.|| . .. |||| | || .|..  ||||.|||.  | .||||.|.| .|  .|.
vdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LTNTEENGEEQSVQYWPVNpNEEDMYGSFNVVALPEERALPDYIVRKFKLSHSKNpDDSRTITHFQYINWPSTSCPKEATSMIDLVADV---VRIQRK-S
.|   |..  .  .||| . .   . | . ||.|  .   |.| || ..| . .   ..| .  .....||. . .  | ..| .| ||   . ..|. |
mtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardas

GNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
. ||. ||.. |.||.|.. |......||.    .||  .|  || .| ..|. . |. .. .|   . .|
evGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 410-653 2.9e-53 175.6 In-house 15-266 (270) alignment 
Range on Protein: 410-653
Range on HMM: 15-266/270.0
AQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQ-RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNP
 .   . .  | .. ||    ||.|.. . |  . || | || |. . . ..||..||...|  .||||.|| |.  |.|.|. ||.| ..  .||| .|
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

NE--EDMYGSFNVVALPEERAlPDYIVRKFKLShskNPDDSRTITHFQYINWPSTSCPKEAT------SMIDLVADVVRIQRKSGNG-PITVHCSDGLGR
.|  . ..|  .|.|| ||..   ||... .|    .  ..| ..||.| .||  . |.|.       ... ....| | ...  .. |. ||||.|.||
kekvkledgkikvlalseeke.egyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

TGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
|||. |. .... |. .. .|| . .. || .|. .|.  .||||..|| .|....
tGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
0036282 (Phosphotyrosine protein) phosphatases II 150-350 6.1e-53 174.4 In-house 1-163 (174) alignment 
Range on Protein: 150-350
Range on HMM: 1-163/174.0
GSDYINASFIGGLNSPKDYIATQGPIPaafpdFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSfgaanygsfqvtlkevetvadyairtfqlqslHGQ
||||||||....   .. .||.||| .     ||.|..|... |..|....||... ||..|||.                                . .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

GPIKEVRQYHFLVWPDHGVPQYATpLLSFQKRVRNHHKG-KPGPMVVHCSAGVGRTGTFITIDTMIMKIDaEGIVDIFNFVRGMRFCRNYMVQTASQYDF
 . ... ||..| |||||||  .. ||.| |.|.....  . ||..||||||||||||.. .. |.. .  |. ||....|| .|..| .|||| ||| |
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

LH
|.
ly
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 388-651 1.3e-52 173.7 In-house 22-279 (439) alignment 
Range on Protein: 388-651
Range on HMM: 22-279/439.0
FQSQFETLESSSPtDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIII
|.  ||...| || |   ..|.|  . . .| | |.  . .  ||.|        | || | |..|| .   .|||||| |.|. ||||.|.| |.. |.
fkeifekinstsp.dyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtiv

MLTNTEENGEeqsvqYWPVNpnEEDMYGSFnVVALPEERALPDYIVRKFKLSHSKN-PDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKSGN
||||  |        ||| .  .| .||   .|    .  ||.|..| ||.   ..  .  ||. .|.|| ||    | .|. ..|..  .   . |   
mltnlvesyk.....ywpsd..aevcygdi.avrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeey

GPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
||. |||| |.|||||  |.   ||.||.|. .|.   || || ||  .|... || ||..| || .
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 385-651 3.4e-49 162.2 In-house 5-259 (267) alignment 
Range on Protein: 385-651
Range on HMM: 5-259/267.0
KTGFQSQFETLESSSPTDDDFDCSIAqlSDNLAKSRVKEHLPPNDYRVVLSTKNYDsdYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMII
.. .. .|| ..  |.|     .|||  ..| .. |. . || .| ||.|.||. .  || ||||.||... |||.||.|.||| .||. .. . |  .|
eceiekefelikkisdtsstisqsia..eknqernrlddnlpyddtrvilrtkeee..yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

IMLTNTeenGEEQSVQYWPVNPNEEDMYGSFNVVAlPEERALPDYIVRKFKLSHsKNpDDSRTITHFQYINWPSTSCPKEatSMIDLVADVVRIQRKSGN
..||..   ....  ..|| .  .   |  . |     |.   || .  ..|   || . .. .| . | .|   .  |    .  |.. . . | . ||
vlltkv...ftdnirlfwPPkmgqakkyqdltveh.slekeendyqiitlelkf.kn.esahnvtlyyykkwnintnnkp..ylkplfgilaknqlengn

GPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
 |. |.||||.||.|||  . . |||.| |.| |.|  .. .| ||.|.|.  ..| .||.   |. 
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
0051429 (Phosphotyrosine protein) phosphatases II 441-653 6e-48 159.1 In-house 4-227 (272) alignment 
Range on Protein: 441-653
Range on HMM: 4-227/272.0
SDYICASYVDGYRQ---RSAFIATQGPMKNTAGDFWRMvWEMKSMIIIMLTNTEENGEEQSVQYWP---------VNPNEEDMYGSFNVVALPEERALPD
|.|| |..|.|| .   . ......||...|| ||||. .|..   |..|...|| | ..  .|||         ..  ....   . .| | .|  |.|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEAtsMIDLVADVVRiqrksgNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVID--------VF
||.|.. |..  .....|...|..|..||  . |.||  ...|.. . .      .||. |||| | .||||..|.. .|... .|...|        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

STVKTLRIQRPGFVNDIDQYEFIHKAALEFVNT
 .|. || ||||.| . .||.|...|.||....
eaveelraqrpgavqteeqylflyeallellrs
subfamily_PTPN1_pd Subfamily PTPN1 399-651 7.2e-48 157.8 In-house 19-271 (290) alignment 
Range on Protein: 399-651
Range on HMM: 19-271/290.0
SPtddDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKnyDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQS
.    ||... |.|  | .. | ..  | .  |..|  .  | ||| || |.  . .  .| ||||. ||.. ||.|||| ||  ..|| .  |... . 
as...dfptreaklpenrnlnryrdvspydhsriklera..dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

VQYWPVNPNEEDMYG---SFNVVALPEERAlPDYIVRKFKLSHSKnPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQR-KSGNGPITVHCSDG
.|||| . .|. .     ...|  . |||    |.||...|   |  ...|.|.|| |. ||  . |.  ....... .| .    .|  ||  .||| |
aqywPqgeeekellledtklkvkliseerk.syytvrllelenlk.tqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

LGRTGTFCAMFTVLERLKAEQV---IDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
.||.|||| . |.| ......    .|.  ..  || .| |..   || .| . | || .
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 415-649 5.6e-47 155.0 In-house 3-237 (237) alignment 
Range on Protein: 415-649
Range on HMM: 3-237/237.0
NLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQ-RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPvNPNEEDMYG
| .|.|  .    .  ||||     .|||| |.|..|.      .||.|||....  |||.|||. |  .|.|||   |. |..  .||| . ..   ||
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaayg

SFNvVALPEERALPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRK-SGNGPITVHCSDGLGRTGTFCAMFTVLERLK
 .  |.|  . .. || || . ||.  .  . | |  .|.  ||    |....... .  ...   .. |  ||  .||| |.|||| |  . ..| . |
vlt.vslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

AEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
 ..|.|..  |...  .||  ..  ||| |||.. ||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0043147 (Phosphotyrosine protein) phosphatases II 148-350 1.4e-46 153.6 In-house 2-154 (172) alignment 
Range on Protein: 148-350
Range on HMM: 2-154/172.0
NPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLkeddkikchqywpsfgaanygsfqvtlkevetvadyairtfqlqSLH
..||||||||.. .   |...|||||| .  ..|||||..|... .|...|.|                                             . 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lyd

GQGPIKEVRQYHFLVWPDHGVPqYATPLLSFQKRVRN-HHKGKPGPMVVHCSAGVGRTGTFITIDTMImkidaEGIvDIFNFVRGMRFCRNYMVQTASQY
...  ... ||..| |||||||  .  ||.| . ... ... . ||..||||||||||||.. .. |.     .|. .... |. .| .|...||. |||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqy

DFLH
 ||.
rfly
0046846 (Phosphotyrosine protein) phosphatases II 144-355 2.8e-45 149.5 In-house 5-171 (176) alignment 
Range on Protein: 144-355
Range on HMM: 5-171/176.0
KPDGNPGSDYINASFIGGLnspkDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYgsfqvtlkevetvadyairtfql
..  ....|||||..| |      .||||||.|  ..||..|..|... .....|...| ...||..||| . ....                       
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

qslhgqgpikevrQYHFLVWPDHGVPQYaTPLLSFQKRVRNHHKGKpGPMVVHCSAGVGRTGTFITIDTMIMkidaEGIVDIFNFVRGMRFCRN-YMVQT
             ||..| |||||||.. . ||.. . .|.. | . || .||||||.|||||.. .. ..     |  ..... .. .| .|  ..|||
.............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqt

ASQYDFLHHAILE
 .|| ||....|.
peQyrflyefell
0049772 (Phosphotyrosine protein) phosphatases II 97-356 5.3e-45 149.8 In-house 19-279 (314) alignment 
Range on Protein: 97-356
Range on HMM: 19-279/314.0
NSDRLEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDhSRVTLKPDGNPGSDYINASFIGGLnspKDYIATQGPIPAAFPDF----------WRMI
.. .|.  . ....  ..| ..|.|. |. |||| .|.|.| .|| |.  .. ||||||||.. |    ...|||||| .  . ||          |||.
lklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmv

--WEYNVPTIIM---------------------VTNLKEDDkikchqywPSFGAANYGSFQvtlkevetvadyairtfqlqSLH--GQGPIKEVRQYHFL
  ...|| .| |                      ..| .          .   ||..  ..                    . .  .. . ... .|. .
lrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........neptaadlellk....................eelydpelferlgikylri

VWPDHGVPqYATPLLSFQKRVRNHhkGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAeGIVDIFNFVRGMRFcRN---YMVQTASQYDFLHHAILEA
 .||...|     ...| . ....   |.|| .|||.||.||||||.... .... .   . .....|| .|.  |    ....  || | ..|.||.
pvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilealley
0036282 (Phosphotyrosine protein) phosphatases II 441-645 4.2e-44 145.6 In-house 2-164 (174) alignment 
Range on Protein: 441-645
Range on HMM: 2-164/174.0
SDYICASYVDGYRQRSAFIATQGPMKntagdFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVnpneedmygsfnvvalpeeralpdyivrkfklshsK
|||| ||..|...  . .||.|||..     ||.|..| .. ...||.. .|.| .   .|||                                    .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................l

NPDDSRTITHFQYINWPSTSCPKEATsMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKaEQVIDVFSTVKTLRIQRPGFVNDIDQY
  | .|.. ...|..||  ..|  .. ....|  | ... ....||. |||| |.|||||..|.. .| .|. | ..|....|..|| |||| |   .||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

EFIHK
.|...
rflyy
0049260 (Phosphotyrosine protein) phosphatases II 158-350 4.8e-44 145.0 In-house 1-143 (152) alignment 
Range on Protein: 158-350
Range on HMM: 1-143/152.0
FIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWpsfgaanygsfqvtlkevetvadyairtfqlqslhgqgpikevrQ
|| | . |. .|||||| |  ..|||||..|... ||.|.|.| |..|.||.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMImkidaeGIVDIFNFVRGMRFCRNYMVQTASQYDFLH
|..| |||||||. .  || . . .. . . | || .||||||||||||.. .. |.        |.....|. .| .|...|.. .|. ||.
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 122-358 1.9e-43 143.7 In-house 39-278 (307) alignment 
Range on Protein: 122-358
Range on HMM: 39-278/307.0
PINHGKNRYVNIIPYDHSRVTLKPDGNpGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGA--AN
  |  |||| ..   |..|. .| ||   |||| | ..|    || .|..|||  ..  .|| |. . .| ..||. .. |  ||||.||||        
santdknryqdvkcqdkgrivvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

YGSFQVTL----KEVETVA--DYAIRTFQLQSLHGQGpIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRnhhkGKPGPMVVHCSAGVGRTGTFITIDTM
.|.   |.      ....|  .  |   .|.   .|.  . .... .  |||.||||     . . . ||    ..  |.||||||||||.|| ..|  .
fgeapntisvanlgakklapdedlinvttlkvdwaqk.srtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvvvhcsaGvGrsGtivaislv

IMK-IDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIM
  | |. .   |. ..|. .|  |.| .||  || .||  .||  .
qdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 124-355 2.7e-43 142.9 In-house 33-257 (267) alignment 
Range on Protein: 124-355
Range on HMM: 33-257/267.0
NHGKNRYVNIIPYDHSRVTLKPDGNPgsdYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDkIKchQYWPSF-G-AANYG
|. .||. . .|||..|| |.   .    |||||.. | .  . .|.||.|.  .  ||. .| ...||.|...|.  .|. |.  ..||   | | .| 
nqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn.ir..lfwPPkmgqakkyq

SFQVTLKEVETVADYAIRTFQLQSLhgQGPIKEVRQYHFLVWPDH-GVPQYATPLLSFQKrvRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAE
 . |     .   || | |..|.    .   ..|  |..  |        |  ||.      .|. .    |.||.||.||||.|||..||... ..  |
dltvehslekeendyqiitlelkfk..nesahnvtlyyykkwnintnnkpylkplfgila..knqlengnrPlvvacsdGvGrsGtflvidsqlerakte

GIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILE
|..|||.|.| .|  |  .|.|  .| ..|. . |
gvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 125-355 7.3e-43 141.3 In-house 57-281 (290) alignment 
Range on Protein: 125-355
Range on HMM: 57-281/290.0
HGKNRYVNIIPYDHSRVTLKpDGNPGsDYINASFIGGLNSPkdYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFG--AANYGS
  |||| ...  | .|| || || .| ||. | .. ||...  .| |||.. ..  |.|||. . .| .|.|. .| || | ||.||.|     .  .|.
fkknrykdvvcndktrvilk.dGydG.dyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

FQVTLKEVETVADYA-IRTFQLQSlHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNhhkgKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEG
. |.  | ..  .    .|. ..    .|  . .. ..   |||. |.. .  ||   . .|.     .||.|||||||.||||||..|.. .  .    
itvlcseeddkdaniikktlsvrd.kdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGk

IVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILE
 .|. . || .| .|   ||   ||  | ...|.
eldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 415-649 7.7e-43 141.3 In-house 7-238 (239) alignment 
Range on Protein: 415-649
Range on HMM: 7-238/239.0
NLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQ-RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPvnpNEEDM
| || |  . .  .  ||||   .    |||| |||.  |     |.||||| .. ..||||||.|. .  .|.|||   |  ...  ||||   .    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstsk

YGSFNVvALPEERALPDYIVRKFKLSHSKNPdDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRiQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERL
|  . | .| .   . |||.| | .|.  .  . | . ....  ||    |. ||... |   . . .   |  |  .||| |.||||.|  . ..| . 
ycnlrv.tlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqa

KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
| .. .|.|  ||..| .|| .|.  .|| ||| | ||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 415-649 1e-42 140.9 In-house 8-239 (239) alignment 
Range on Protein: 415-649
Range on HMM: 8-239/239.0
NLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQ-RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPvnpNEEDM
| || |  . .  .  ||||   .    |||| |||.  |     |.||||| .. ..||||||.|. .  .|.|||   |  ...  ||||   .    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstsk

YGSFNVvALPEERALPDYIVRKFKLSHSKNPdDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRiQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERL
|  . | .| .   . |||.| | .|.  .  . | . ....  ||    |. ||... |   . . .   |  |  .||| |.||||.|  . ..| . 
ycnlrv.tlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqa

KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
| .. .|.|  ||..| .|| .|.  .|| ||| | ||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
0041856 (Phosphotyrosine protein) phosphatases II 415-651 1.3e-42 140.8 In-house 1-171 (182) alignment 
Range on Protein: 415-651
Range on HMM: 1-171/182.0
NLAKSRVKEHLPPNDYRvvlstknyDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTnteengeeqSVQYWPvnpneedmygs
|| | |... ||..  |        |.||| |....|..  . |||||||...|  ||.||..|..  .|..||         ...|||           
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...........

fnvvalpeeralpdyivrkfklshsknPDDSRTITHFQYINWPSTSCPKeatsmIDLVADVVRIQRKsGNGPITVHCSDGLGRTGTFCAMFTVLERlkae
                            .  |......|..||  ..|      .| . | ... ..  .||. |||| |.|||||..|.. ....    
...........................ellerlgiqylylpwpDhgvpd.....ldelldfieevle.eggpvlVHCsaGvgRtgtlvaaylmkkl....

QvIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
. ......||..| .||| |   .|| |.. |.||..
g.vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 400-649 3.3e-42 139.3 In-house 30-234 (392) alignment 
Range on Protein: 400-649
Range on HMM: 30-234/392.0
PTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGeeq
|  | .. ..||  .|| | | |. || .  ||.|       ||||. |||.... .  |.||.|||   .  ||||||.. .   |.|.|. .|     
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...

svqywpvnpneedmygsfnvvalpeeralpdyivrkfklshskNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADvVRIQRKSGNGPITVHCSDGLGR
                                           . || ||.. |.. .||    || ..|.. .. . |...  .   |. .||| |.||
...........................................kgddartvaqfhftewPdkdvpkhtssllkfike.vkadfGqythpliihcsagvgr

TGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
||   .. .|. . |  ...|||  |  .| .|| .|.  .|| ||. | ||
tgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_ptpA1_pd Subfamily ptpA1 124-318 8.9e-42 138.3 In-house 47-257 (418) alignment 
Range on Protein: 124-318
Range on HMM: 47-257/418.0
NHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINASFIGGlNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPS--------
|  |||| ||.| .|.|| ||  . . ||||||| .| |   ||..|.||||.| .  |||||.||  .  |.|..   |. .||| .|||         
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

-FG--AANYGSFQVTLKEVETVADYAIRTFQLQsLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHK------GKPGPMVVHCSAGVGRTG
 .|     .|.. | | ||    .  | | ... |  .|  ... ||..  |||| .|... |.  . . . |...       .  |..|||||||||||
iygngnevfgtysvelveviqdpereiitrnir.ltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

TFITIDTMIMKID
|| |   |. |.|
tfctavimmkkld
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 402-655 1.2e-40 134.0 In-house 43-287 (290) alignment 
Range on Protein: 402-655
Range on HMM: 43-287/290.0
DDDFDCSIAQLSDNLAKSRVKEhLPPNDYRVVLSTKNYDSDYICASYVDGYRqrSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQY
 . .. .| .   .. | | |. .. ||   |.    || ||. | ||.| .  . || |||..|.|. |.|||| . |   |.|| .  |.|  .  ||
vqylerkifdkntefkknrykd.vvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPVNPNEEDMYGSFNVVALPEERALPDYIVRKFKLsHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDlvadVVRIQRKSgNGPITVHCSDGLGRTGTF
.| .  |   .|.. |.   |.    . | . . .   |.   .  . |.. . ||  | .. . ...     ..|| ||  .||..|||| |.||||||
ypekeGevltfGeitvlcseeddkdaniikktlsv.rdkdsGkehklkhlkikswpdksvalstlallr....tlrilrka.sGpvvvhcsaGiGrtGtf

CAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVNTFD
 |. . |. |   . .|.  .|..||  | . |.   ||  . .. |..   |.
vaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfk
0043147 (Phosphotyrosine protein) phosphatases II 440-645 2.1e-40 133.6 In-house 4-155 (172) alignment 
Range on Protein: 440-645
Range on HMM: 4-155/172.0
DSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTeengeeqsvqywpvnpneedmygsfnvvalpeeralpdyivrkfklsHS
.|||| |||.|.|.    |||||||. ||  |||||..|..  .|..||.                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................ly

KNPDDSRTITHFQYINWPSTSCPkEATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLerlkaeQVIDVFSTVKTLRIQRPGFVNDIDQ
  .. .|.. ...|..||  ..|  .  .....  . ... .| .||. |||| |.|||||..|.. .|      . .... .|...| .||| |   .|
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YEFIHK
| |...
yrflyy
0049772 (Phosphotyrosine protein) phosphatases II 407-654 2.2e-40 134.7 In-house 38-283 (314) alignment 
Range on Protein: 407-654
Range on HMM: 38-283/314.0
CSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYrqrSAFIATQGPMKNTAGDF----------WRMV--WEMKSMIIIM--------
. .|.|  |  | | .. || . .... .  ...|||| ||||||.    .|||||||...|  ||          ||||  ..... .| |        
ilvadlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LTNTEENGeeqsvqywpvnpneedmY----------GsfnvvalpEERALPDYIvrkfklshsknpddSRTITHFQYINWPSTSCPk
             |..  .||                                     ||   |..               .|.. .. .|..|  |.| 
elsrLdaAlgKtpllildgng.................neptaadlellk........eelydpelf..............erlgikylripvpDgsap.

EATSMIDLVADVVRIqrkSGNGPITVHCSDGLGRTGTFCAMFTVLERLKaeqViDVFSTVKTLRIQRP-----GFVNDIDQYEFIHKAALEFVNTF
    . .... . .    . .||. |||..| ||||||...  .. .|.   | ..  ... .| .||     ||..  .|||||..| ||.....
lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg...v.sleealedvrlkRpinpnpgfieqleqyefilealleylkfl
0046846 (Phosphotyrosine protein) phosphatases II 431-650 3.4e-39 129.7 In-house 2-172 (176) alignment 
Range on Protein: 431-650
Range on HMM: 2-172/176.0
RVVLSTKNYDSDYICASYVDGYRqrsaFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVnP-NEEDmygsfnvvalpeeralpdy
|..|.. ..|.||| |....|.|    .||||||. .|  ||..|..|..  ....||.  | |  .  .|||.   ...                    
rlrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi...................

ivrkfklshsknpddsrtitHFQYINWPSTSCPKEaTSMIDLVADVVRIQRKSgnGPITVHCSDGLGRTGTFCAMFtvleRLKAEQVIDVFSTVKTLRIQ
                    ......||  ..|   . ...|.. . . ...   ||. |||| |.|||||..|..     |. |. ..|. .....| |
....................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreq

RP-GFVNDIDQYEFIHKAALEF
|| | |   .||.|.....|..
RplgavqtpeQyrflyefelll
0051082 (Phosphotyrosine protein) phosphatases II 150-354 9.3e-38 124.5 In-house 2-150 (151) alignment 
Range on Protein: 150-354
Range on HMM: 2-150/151.0
GSDYINASFIGGLnspkdYIATQGPipaaFPDFWRMIWEYNVPTIIMVTNLKEDDkiKCHQYWPSFGaanygsfqvtlkevetvadyairtfqlqslhgq
 |||||.|...|      .....||     .||.....|... ||.......| .  .|..|.|. |                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

gpiKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNhhkGKPGPMVVHCSAGVGRTGTFITIDTMIMKidaegiVDIFNFVRGMRFCRNYMVQTASQYDFL
    ||.....| |||.|.|..   .|.| . ...    |.||..||||||.|||||.. .. |...      |...  .. .| .| ..||.  |. |.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

HHAIL
..|.|
lfall
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 409-651 1.2e-37 124.6 In-house 35-277 (307) alignment 
Range on Protein: 409-651
Range on HMM: 35-277/307.0
IAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNE
.  .| |  | | ..    .  |.|. ..   |||| | |.    .   ||..|||..||  .|| |. . |   .||| .. | .. .  ||||..  .
veafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

EDMYGS----FNVVALPEERALPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAM
. ..|.     .|  |  ..  ||  . .    . .  ..||||.|.|. |||   .|.   . |.|.  |     .  . |. |||| |.||.||  |.
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav.....rydtnpvvvhcsaGvGrsGtivai

FTVLERL-KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
  | ... . .   |.   |. || ||.  ...  || ..|.  ||. 
slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0049260 (Phosphotyrosine protein) phosphatases II 448-645 1.8e-37 123.7 In-house 1-144 (152) alignment 
Range on Protein: 448-645
Range on HMM: 1-144/152.0
YVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWpvnpneedmygsfnvvalpeeralpdyivrkfklshsknpddsrt
..|||..  .|||||||. ||. |||||..|..  .|.|||. .|.|...  ||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

itHFQYINWPSTSCPKEATSMIDLVADVVRIqRKSGNGPITVHCSDGLGRTGTFCAMFTVLerlkaeQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHK
  ......||  ..|. .  ...|.  . .. ... .||. |||| |.|||||..|.. .|      . .... .|. .| .||| |   .|..|...
..qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0044763 (Phosphotyrosine protein) phosphatases II 135-354 2.9e-37 123.4 In-house 1-168 (178) alignment 
Range on Protein: 135-354
Range on HMM: 1-168/178.0
PYDHSRVTLKP-DGNPGSDYINASFIGglnsPKDYIATQGPipaafPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAanygsfqvtlkevetv
|.|..|| | .  | ..|||||||.|     |  |.....|     .|......|... .|...|. .|  ..||..|||.                   
pldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

adyairtfqlqslhgqgpikevRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKidaeGIvDIFNFVRGMR
                       ||... .||||||.    .| | . ...... |.|| .|||||||||.||.. .. |..     |. .... .. .|
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvr

FCRNyMVQTASQYDFLHHAIL
 .|. .|.. .|. .|.   |
erRp.ivpnpgqlrqLyefel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 122-358 3.5e-37 122.8 In-house 46-288 (305) alignment 
Range on Protein: 122-358
Range on HMM: 46-288/305.0
PINHGKNRYVNIIPYDHSRVTLkpDGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAAN--
  ..||||| ..   |. || |  .|    .|| | ..     || .| || |.  .  ||| | .. .| .|.|. ||.|    ||..|..|       
aqeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

--YGSFQVTLKEvETVADYA--------IRTFQLqSLHGQGP-IKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHkgkpGPMVVHCSAGVGRTGTFI
   .  ....|  |. . .         ..  .|  . | |   . | .||.  ||| |||   . .| . .. |  .    ||.|||||||.||||. .
feekgqkisvkf.essvtlkfrkdakakvtetvl.viegpgekarkvthyhwidwpdrgvpaadlailellekarpsk....gpivvhcsagigrtgsvv

TIDTMIMKIDAEGIV-DIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIM
 .. .. .. |  |. |    .. .|  ||  .||  || |.|  ||. . 
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
PTPc_DSPc_SM00012 255-355 7.8e-36 117.8 In-house 2-105 (105) alignment 
Range on Protein: 255-355
Range on HMM: 2-105/105.0
VRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKP--GPMVVHCSAGVGRTGTFITIDTMIMKIDAE-GIVDIFNFVRGMRFCRNYMVQTASQYDFLHH
|..||.. |||||||......|.. . |..... .   .|.||||||||||||||...|........| . ||||..|. .|  |. ||||  || ||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AILE
|.||
alle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 122-357 2.9e-35 116.4 In-house 53-289 (305) alignment 
Range on Protein: 122-357
Range on HMM: 53-289/305.0
PINHGKNRYVNIIPYDHSRVTLKpdGNPGSDYINASFIGGLNSP-KDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAAN-
 |.  |||| ..   |.| | |.    . |||| | ..|    | | .|..|||.  .  .|| |. . .|  |.|. .  |  |.|| ||||     . 
diaitknryqdvpcqdqsavkld..kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

YGSFQVTL------KEVETVADYAIRTfqLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRnhhkGKPGPMVVHCSAGVGRTGTFITIDTM
     . .      | .|  |.  | .  |.  .  .    ||. ..  ||| |||      | .   .|    |   |.|||||||.||||| ..|. .
elksgivvenvsgskpmerdaeiqitl..lnltysgdqkmsvrhlqwtewpdrgvppckltslellsair....gskvpivvhcsagigrtgtivaieyi

IMKIDA-EGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
. ||        . ..|. .|  | . .|.  || |.|  .|. .
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 120-355 1.4e-34 114.1 In-house 33-267 (281) alignment 
Range on Protein: 120-355
Range on HMM: 33-267/281.0
KLPINHGKNRYVNIIPYDHSRVTLKP--DGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGA
. |.|  ||||.||   | ||| ||     .  .||| | .|      . || ||||   .  |||||||. |  .|.|. .. | .. || .|.|    
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

--ANYGSFQVTLkEVETVADyAIRTFQLQsLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNhhkgKPGPMVVHCSAGVGRTGTFITIDTMIM
   ..  . |.  |  ||   .. | .|. |  .|  . . .. .  |||  ||. .  .|   ...|     .  | |.||||||||.||.....  . 
cclqfdklsvsy.edstvnk.slvttrln.lsyegetrlithwlwkewpdwqvpessevmlkilrkira....rstppvihcsagvgrsgtlmaveialq

KIDAE-GIVDIFNFVRGMRF-CRNYMVQTASQYDFLHHAILE
 | .   . || . |  .|   |   |||  || .. . .|.
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 399-639 4.2e-34 112.7 In-house 36-269 (301) alignment 
Range on Protein: 399-639
Range on HMM: 36-269/301.0
SPTDDDFDCSIAQLSDNlaKSRVKeHLPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQS
.   |. . | | | ..  | | . ..| .    |   ..     | | ...   .   |||||||.|||. ||| |.   .   |.||... |. ||. 
tidkdhitesyaylpkd..khryp.tvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekc

VQYWPVNPNEEDMYGSFNVVALPEERALPDYIV-RKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVadvvRIQRKSgNGPITVHCSDGLGR
 .| ||...|.   | |..    .|  | . |. |....  | .  ..||.||.|| .|.    ||  . . ||.     . .|| . || ||||.|.||
eeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm....elvkks.ekPivvhcsaGiGr

TGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQ
. .| .   .  ...|.. |..  ..| || .|   |.   |
svafigteylareveadptieltealkhlrehrwngvqtnsq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 122-358 5.1e-34 112.5 In-house 33-271 (285) alignment 
Range on Protein: 122-358
Range on HMM: 33-271/285.0
PINHGKNRYVNIIPYDHSRVTLKpdgNPGSDYINASFIGGL-NSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPS-FG-AA
  |   ||| ..   . .|| ||   |   ||| ||..    .    ||.||||.| .. |||.||.. ..  ..|.  | |    ||  |.|  .|   
eanpdlnryadvrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

NYGSFQVTLKEVE--TVADYAIRTFQLQslHGQGPIKE---VRQYHFLVWPDHGVPQYATPLLSFQKRVRNHhKGKPGPMVVHCSAGVGRTGTFITIDTM
..| ...|| |..  ..|   . .. .     .    |   . . .   |||.  |. | |.. . | |..  . |  |..|||||||||| ||. ||  
kfgkyeitlteckeeaiagtilnaltvi..ntedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrtatfvgidya

IMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIM
 ..|  .  ..... || ||  |   ||.  |. ||.  ..| ..
tirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 119-282 7.7e-34 111.9 In-house 28-193 (297) alignment 
Range on Protein: 119-282
Range on HMM: 28-193/297.0
AKLPINHGKNRYVNIIPYDHSRVTLKpDGNPGSDYINASFIGGLNSPKD--YIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFG
|| .    |||| .|. .| .|| |.  . ...||||| ..   . ..|  || .|||. |.  |||....| .| .|.||..|.|| . ||  ||||  
akrnsslrknryrdilatddtrvkll.rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

AANYGSFQVTLKEVETVAD-YA-IRTFQLQSLHGqGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRV
  .  . .| .. . ...| .  .   .|| ..     . ||   || |||||||     |  || .|
qerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_ptpA1_pd Subfamily ptpA1 407-611 1e-32 108.4 In-house 39-256 (418) alignment 
Range on Protein: 407-611
Range on HMM: 39-256/418.0
CSIAQLSDNLAKSRVKEHLPPNDYRVVLST--KNYDSDYICASYVDGYRQRsAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPV
 |  .   | .| |  . || |  || |     .  |||| | |.||   .  ||.||||. ||  |||||||| .  ||.||.   ||   .  .||| 
tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpe

NPNEE--DMYGSFNV------VALPEERALP--DYIVRKFKLSHSknpDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQR-----KSGNGPITV
.   |   .||  |       | | |    |  . | |. .|.      ..| ||..||  ||    |  .  . .|.  .   |         | || |
qiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe...getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

HCSDGLGRTGTFCAMFTVLERL
||| |.|||||||.   ....|
hcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 126-348 6.9e-32 105.4 In-house 52-272 (301) alignment 
Range on Protein: 126-348
Range on HMM: 52-272/301.0
GKNRYVNIIPYDHSRVTLKPDGNpgSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAA--NYGSF
 |.|| ..    .. | .  ||.     | | .|     |. .||||||....  ||| |.  |.| .|.|...  |. . ||..| |.  .   . | |
dkhryptvPckPstavevivdGk..rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

QVTLKEVETVADYAI--RTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKgkpgPMVVHCSAGVGRTGTFITIDTMIMKIDAEG
....|. |.. .  |  ||....   |. . . |  | .  |.|.|||.  . |  . . |.. .|    |.|||||||.||. .||. . .  ...|. 
kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigteylareveadp

IVDIFNFVRGMRFCRNYMVQTASQYDF
 ... . .. .|  |   ||| ||  .
tieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 415-651 9.5e-32 104.8 In-house 53-289 (305) alignment 
Range on Protein: 415-651
Range on HMM: 53-289/305.0
NL--AKSRVkEHLPPNDYRVVLSTKNYDSDYICASYVDGYR-QRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDM
..  .| |  . .| .|  .|.  |   |||| | ||         ||..|||. .|  .|| || . |   |.|| .| | |  .  ||||.   |   
diaitknry.qdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

YGSFNVVA-----LPEERAlPDYIVRKFKLSHSknPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFT
  |  ||       | ||  ..  .  ..|..|   |.. .. |.|. .||    |    . ..|.. .     .  . || |||| |.|||||  |.  
lksgivvenvsgskpmerd.aeiqitllnltys..gdqkmsvrhlqwtewpdrgvppckltslellsai.....rgskvpivvhcsagigrtgtivaiey

VLERLKAE-QVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
.||..  . ..  .   ||.|| ||   ...  || |||.  |...
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
0051082 (Phosphotyrosine protein) phosphatases II 441-647 1.4e-31 104.5 In-house 3-149 (151) alignment 
Range on Protein: 441-647
Range on HMM: 3-149/151.0
SDYICASYVDGYrqrsaFIATQGPMKntagDFWRMVWEMKSMIIIMLTNTEENGeeQSVQYWPVNPneedmygsfnvvalpeeralpdyivrkfklshsk
|||| .|||.|.     .....||.     ||.....|..   |..|...||.|     .|.| .                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

npddsRTITHFQYINWPSTScpkeATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERlkaeqvIDVFSTVKTLRIQRPGFVNDIDQY
     ....|.....|| ..       ..| |...... .. .|||. |||| |.|||||..|.. .|..      ........ .|..|||.|.  .|.
.....ievlhipildwpdpg....lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

EFIHKAA
 |...| 
lfqlfal
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 101-360 3e-31 103.5 In-house 21-274 (288) alignment 
Range on Protein: 101-360
Range on HMM: 21-274/288.0
LEEEYPDIELEWNFTSyAAKLPINHGKNRYVNIIPYDHSRVTLKPDGnpgSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNL
|. || |   | .  . . .   |  ..|| |.   | .|| |. |      ||.|  .   . ..  | .| |. ..   .|.|. | .|  |.|...|
lkkeyrdspneasidi.idsfianptrdryenlprcditrvklsddp...dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcel

KEDDKIKCHQYWPSF-G-AANYGSFQVTLKEVETVADyaiRTFQLQSLHGQGPI--KE-VRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKgkpgPMVV
 |  | |  .|.||  | .| .| .    |.  .  |   .. ..  |. . ..  |  |.. |.| |.|.|||.   . | . .......|    |.||
lekGkeksaeyfPsklGekarigrlctvvkkkradid...klvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....Pivv

HCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCR
|.|||||||||.| |  ..  .  .  . | ...  .|  |   .||  || ..|  .|| .. .
hssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 455-645 3.2e-31 103.1 In-house 4-198 (199) alignment 
Range on Protein: 455-645
Range on HMM: 4-198/199.0
RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALpEERALPDYIVRKFKLSH-SKNPDDSRTITHFQY
.  .|||| |...|  |||.||||  |  |.|. . . | | .   |||.  .    |||..|..     . ||| .  . |.  .  |  .| |.|.|.
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttk.tittkpdytitaliltnnttappstreishyqf

INWPSTSCPKEATSMIDLVA--DVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERL--KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHK
  |   . |. |  .  .||  .| .   .  . |. |||||| | || | |.   .         |.|.|   | ||  | | .  ...|.||..
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 456-645 3.5e-31 102.9 In-house 4-197 (198) alignment 
Range on Protein: 456-645
Range on HMM: 4-197/198.0
SAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALpEERALPDYIVRKFKLSH-SKNPDDSRTITHFQYI
  .|||| |...|  |||.||||  |  |.|. . . | | .   |||.  .    |||..|..     . ||| .  . |.  .  |  .| |.|.|. 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttk.tittkpdytitaliltnnttappstreishyqft

NWPSTSCPKEATSMIDLVA--DVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERL--KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHK
 |   . |. |  .  .||  .| .   .  . |. |||||| | || | |.   .         |.|.|   | ||  | | .  ...|.||..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_CG42327_pd Subfamily CG42327 121-287 3.7e-31 103.0 In-house 24-195 (319) alignment 
Range on Protein: 121-287
Range on HMM: 24-195/319.0
LPI-NHGKNRYVNIIPYDHSRVTLKPDGN-PGSDYINASFIGGLN-SPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSF--
.|.  . |.|..|..|  ..||.|.  |. . . |..||.. | . .|  |||.| .   .  ||||..|| .  .|. .|.| |    .| .|.|.   
vPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket

--GAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGpIKEVRQYHFlVWPDHGVPQYATPLLSFQKRVRNHHK
  .   || ..||||. |.   ||| |. |. ....   .|.  | .  |.. .||   ..|..   .||.  |
ldntslyGdilvtlkgrevkdryaistlllkrvdkee.srelthywy.kwleaevPaeeaaliamllevrsslk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 254-394 3.7e-31 102.9 In-house 90-231 (440) alignment 
Range on Protein: 254-394
Range on HMM: 90-231/440.0
EVRQYHFLVWPDHGVPQYATPLLSFQKRVRN-HHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHA
 ..|||.  |||.|||..| |.| . . | . ..|   ||..||||||.||||  |..|... .      .|||.|.  ||  |  ||||  || |.|.|
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea

ILEAIMCRDTTIPAVHMATKIATLKEIAPSSGKTGFQSQFET
.||...| || |    .. ..  ..   | . |. .| .|| 
vlegllcgdtliledditerveqiqwpnphtdksplqqefeg
PTPc_DSPc_SM00012 547-649 5.6e-31 102.2 In-house 1-105 (105) alignment 
Range on Protein: 547-649
Range on HMM: 1-105/105.0
TITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKSG-NGPITVHCSDGLGRTGTFCAMFTVLERLKAE-QVIDVFSTVKTLRIQRPGFVNDIDQYEFIH
|..|..| .|| ...|.|..|...|...| . ..||. ..|. ||||.| ||||||.|. ..|..|..| . .|.| .|| || |||| |.  .|| |..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

KAALE
.| ||
ralle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 124-354 5.4e-30 99.0 In-house 52-287 (310) alignment 
Range on Protein: 124-354
Range on HMM: 52-287/310.0
NHGKNRYVNIIPYDHSRVTLKPDGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAA-NYGS
.  |||| ...  | ||| || |     ||| | ..      . .| .|||.  .  ||||||..    .|... .  |. . ||  ||||.| .  || 
ymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygc

FQVTLKeVETVADYAIRTFQLQSLHGQGPIK-------EVR--QYHFLVWPDHGVPQYATPLLSfqKRVRnhHKGKPGPMVVHCSAGVGRTGTFITIDTM
 .||    |.  .. |  . .  .  . |.        |.|    ..  ||| |||.     .   .|.    . . || |||||||..|... ....  
irvtnl.sesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrll..aqvrhgpcvvhcsagkdrlyvvvalklk

IMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAIL
| |.|    ||. . .  ..  |   .||  || ....  .
idkldrglkvdaeevktellksraiciqtelqyliidrvri
0044763 (Phosphotyrosine protein) phosphatases II 429-649 1.6e-29 98.2 In-house 4-169 (178) alignment 
Range on Protein: 429-649
Range on HMM: 4-169/178.0
DYRVVLST--KNYDSDYICASYVDGYrqrsAFIATQGPmkntaGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNeedmygsfnvvalpeeral
..||.||.      |||| ||.....     ......|      |......|..   |..||.. |.| ... .||| . .                   
rtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...................

pdyivrkfklshsknpddsrtiTHFQYINWPSTSCPKeATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERlkaeQViDVFSTVKTL
                       ....|..|  ..|   ..... . . ..  ... .||. |||| |.||.||..|.. ....    .. .... .. .
......................iqylhipipDhgvpd.llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RIQRPgFVNDIDQYEFIHKAALE
| .|| .|   .|...... .|.
rerRp.ivpnpgqlrqLyefelr
subfamily_egg_pd Subfamily egg 388-650 3.1e-29 96.6 In-house 16-269 (307) alignment 
Range on Protein: 388-650
Range on HMM: 16-269/307.0
FQSQFETLESSSpTDDDFDCSiaQLSDNLAKSRVKEHLPPNDYRVVLSTK--NYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIII
.. ..| || |.  .  .  .    ..|| |.| |     .  || |  .   |  |.| | .|.|      || .| |.|||  ||||||.. .   |.
lerrlevleesv.deisltta..asdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyiv

MLTNTEENgeEQSVQYWPVNPNEEDMY--GSFNVVALP-EERALPDYIVRKFKLSHSKnpDDSRTITHFQYiNWpstscpkEATSMIDLVADVVRIQRKS
||| . |.  |.   |||  ...  ..  ||... .|  ...| | . | |.||  ..  |. | . |.|. ..       . .| .     |.|  |. 
mltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqg.dv.......nnssdvysplrvlrklrnl

GNgPITVHCSDGLGRTGTFCAMFTVLERLKAEQV--IDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
 . |. |.. .|  ...|. |. . |  |    .    |  .|. || .|.  |. . .| |...  | |
sk.pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 415-652 3.7e-29 96.4 In-house 48-288 (305) alignment 
Range on Protein: 415-652
Range on HMM: 48-288/305.0
NLAKSRVKEHLPPNDYRVVLsTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMY--
.  | | |.    .. || |    .  .|| | ||    .   || || |...|  ||| | .. |   |.|| |  | | .. ..|.. . ...  .  
eagknrykdvgcldnnrvkl.egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

------GSFNVVALPEERALPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFT
        |.  .  . |.  .  |.. .|       ..| .||. .|.||    |   .....|...      ..  |||.|||| |.||||.   .  
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka.....rpskgpivvhcsagigrtgsvvmley

VLERLKAEQVIDVFS-TVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
.|..| | |.|.     .. .| ||   ..  .|| |.|.  |....
ildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 428-650 8.3e-29 95.4 In-house 48-269 (285) alignment 
Range on Protein: 428-650
Range on HMM: 48-269/285.0
NDYRVVLstKNYDSDYICASYVD-GYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVV-ALPEERA
.. ||||  ||.| ||| ||..    ...|..|.||||. .|  |||.|... |   ..||    | | |.   |.| .  |   .| ...  .  .| |
eetrvvl..knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeea

LPDYIVRKFKLSHSKNP-DDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKsgNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVK
.   |.  . .  ...   .   . | |   ||   .|..|  ||.|   | ... |  . || |||| |.||| ||  .     |.  .  |...  |.
iagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivr

TLRIQRPGFVNDIDQYEFIHKAALEF
 .|  |   |.   |. |..   .|.
emramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 407-654 1.5e-28 94.2 In-house 29-272 (281) alignment 
Range on Protein: 407-654
Range on HMM: 29-272/281.0
CSIAQLSDNLAKSRVKEhLPPND-YRVVLST----KNyDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQY
|.. .   |  | |  . .|  |  || |      ||  .||| | |.     .  .| |||| |.|  |||||.|. ..  |.|| .  |   |.  .|
ctvfnqpvnnkknryln.ipcldisrvqlkvkmpnkn.stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPVNPNEEDMYGSFNVVAlpEERALPDY-IVRKFKLSHSknpDDSRTITHFQYINWPSTSCPKEATSMIDLVAdvvRIQRKSgnGPITVHCSDGLGRTGT
.| |      .  . |    |. ..    .  ...||.     ..| |||. . .||    |. .  |. ..    .|. .|   |  .||| |.||.||
fprnahcclqfdklsvsy..edstvnkslvttrlnlsye...getrlithwlwkewpdwqvpessevmlkilr...kirars..tppvihcsagvgrsgt

FCAMFTVLERLKAEQV-IDVFSTVKTLRIQ-RPGFVNDIDQYEFIHKAALEFVNTF
. |.   |. ...     |.   |  ||.  |   |. ..|| .| |  |.|  ..
lmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvay
0048076 (Phosphotyrosine protein) phosphatases II 220-353 6.2e-28 92.7 In-house 13-139 (145) alignment 
Range on Protein: 220-353
Range on HMM: 13-139/145.0
YGSFQvTLKEVETVADYAIRTFQLQSLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKpGPMVVHCSAGVGRTGTFITIDTMIMkida
.||.  | ...|. .|. |.|    .   ... ... ||..| |||||||. .  ||.| . .....| . ||..||||||||||||.. .. |..    
lgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....

EGiVDIFNFVRGMRFCRNYMVQTASQYDFLHHAI
.| |.... .. .| .| ..|.. .|. ||. ..
lg.vsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 389-650 3e-27 90.4 In-house 15-270 (288) alignment 
Range on Protein: 389-650
Range on HMM: 15-270/288.0
QSQFETLES---SSPTDDDFDcSIAQLSDNLAKSRVkEHLPPNDY-RVVLStknYDSD-YICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMI
|  .|.|.     || .   | .| .  .| .. |  |.||  |. || ||    |.| || |  |   . .  .| .| |.. | . .|.|. |     
qiaveglkkeyrdspneasid.iidsfianptrdry.enlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdvey

IIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVAlPEERALPDYIVRKFKLSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVvriqrKSG
|.||..  | | |.| .|.|..  |.  .| .  |   ..||  | .|.   |  ||. ...  . .  . .|.  . |..  | . |.  .     || 
ivmlcellekGkeksaeyfPsklGekarigrlctvv.kkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....ksl

NGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEF
. || ||.| | |||||.  .. .|| |. .  . . | .. || .|   ..   || ..|.  || 
qkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
0048179 (Phosphotyrosine protein) phosphatases II 238-351 1.5e-26 88.2 In-house 48-139 (144) alignment 
Range on Protein: 238-351
Range on HMM: 48-139/144.0
IrtfqlqslhgqgpikeVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKgKPGPMVVHCSAGVGRTGTFITIDTMImkidAEGiVDIFNFVRGMRFCRN
                 . ||..| |||||||.... ||.| . ...... ..||..||||||||||||..... |.     .| ..... .. .| .| 
e................giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrp

YMVQTASQYDFLHH
..|.. .|. ||. 
gavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 126-244 2.9e-26 87.0 In-house 49-183 (350) alignment 
Range on Protein: 126-244
Range on HMM: 49-183/350.0
GKNRYVNIIPYDHSRVTLK-----PDG----NPGSDYINASFIGGL------NSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQ
 ||||.||.||.|||| ||     .|.      ..|||||...         |.   |||||.|.| .. ||...| . .|. |...|.. | .  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPSFGAAN-YGSFQVTLKEVETVADYAIRTFQLQ
||.  .  .    .. . ...  . | ........
YWqegsydditvklaskwenimgindsslysadvk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 127-360 6.7e-26 85.7 In-house 46-279 (312) alignment 
Range on Protein: 127-360
Range on HMM: 46-279/312.0
KNRYVNIIPYDHSRVTLKPDGNpgsDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPS-FGAANYGSFQV
 ||| ||  .|  | ||  | |    || | |.     |. ...||||.  .   ||..       .||... . ||   || .|     |  .    .|
lnrypniqcwdrgrftlagden...fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

TL---KEVET--VADYAIRTFQLQ-SLHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHKgkpgPMVVHCSAGVGRTGTFITIDTMIMKIDA
      |.|    .   |    |.  ..  |    . .| .  |||||.|.     | .   |.. .|    |.. |||||||||||.. |..||  .  
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahcsagvgrtgtlaliesmiaalrh

E---GIVDIFNFvrgMRFCRNYMVQTASQYDFLHHAILEAIMCR
     . |.| .   .|  |   |..  || .  ...|| ....
prkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvleflysk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 408-652 7.5e-26 85.4 In-house 45-291 (310) alignment 
Range on Protein: 408-652
Range on HMM: 45-291/310.0
SIAQLSDNLAKSRVKEHLPPNDYRVVLST-KNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNP
.     ... | |  . .  .. || |   |    ||| | ||     ||.|| .|||.. |  |||||... ..  |..| .. |.|  ..| |||   
tyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg

NEEdMYGSFNVVALPEERALPDYIVRKFKLS-----HSKNPDD--SRTITHFQYINWPSTSCPKEATSMIdlvADvvRIQRKSGNGPITVHCSDGLGRTG
  |  ||   |  | |     .       .        ..| .     ..  .. ||| .  | |    .    .  |.  .   ||  |||| | .|..
vte.tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv...pq..rllaqvrhgpcvvhcsagkdrly

TFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
. .|.   ...|.  . .|.   .  |. .|   ..   || .|..  . |. 
vvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 166-350 1.2e-25 84.8 In-house 5-197 (199) alignment 
Range on Protein: 166-350
Range on HMM: 5-197/199.0
KDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPS--FGAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGP-IKEVRQYHFLV
. ||||| |.  .. |||.|.||     |.|| . . . .     |||.   |...|||. || | . | .||.| .. | .     |  .|. .| |  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPQYATP---LLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKID--AEGIVDIFNFVRGMRFCRNYMVQTASQYDFLH
| ..  |. |     ... ..  ... . |  |..|||| | | || |...|  .   .     .||.|.  . .| .|  .. .  .|.|..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 166-350 1.2e-25 84.9 In-house 4-196 (198) alignment 
Range on Protein: 166-350
Range on HMM: 4-196/198.0
KDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPS--FGAANYGSFQVTLKEVETVADYAIRTFQLQSLHGQGP-IKEVRQYHFLV
. ||||| |.  .. |||.|.||     |.|| . . . .     |||.   |...|||. || | . | .||.| .. | .     |  .|. .| |  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPQYATP---LLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKID--AEGIVDIFNFVRGMRFCRNYMVQTASQYDFLH
| ..  |. |     ... ..  ... . |  |..|||| | | || |...|  .   .     .||.|.  . .| .|  .. .  .|.|..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_CG42327_pd Subfamily CG42327 418-574 1.2e-25 84.8 In-house 31-189 (319) alignment 
Range on Protein: 418-574
Range on HMM: 31-189/319.0
KSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQR-SAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNP--NEEDMY
|||| . .|  . ||||  .  |  . |. |||| ||..  . .||.| ...... ||||.||| .| .|. ||.  |.| ..  .|.| .   .....|
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

GSFNVvALPEERALPDYIVRKFKLSHsKNPDDSRTITHFQYiNWPSTSCPKEATSMIDLVAD
| . | .| .  .   |..  . | .  . . || .||. | .|. .  | | ...| .. .
Gdilv.tlkgrevkdryaistlllkr.vdkeesrelthywy.kwleaevPaeeaaliamlle
subfamily_egg_pd Subfamily egg 125-354 9e-25 82.0 In-house 41-267 (307) alignment 
Range on Protein: 125-354
Range on HMM: 41-267/307.0
HGKNRYVNIIPYDHSRVTLK-PDGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDkiKCHQYWPSFG--AANY-
  | |   .   | |||.|. . |    |.| |  . |     ..| .| |.  .  |||||... .|. |.|.|  || .  .|. |||     .. . 
lekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpkaesdslvtv

-GSFQVTLKEVETVADYAIRTFQLQSlhgQGPIKEVRQYHFLVWPDHGVPQYATPLlSFQKRVRNHHKgkpgPMVVHCSAGVGRTGTFITIDTMIMKIDA
 ||....  .|.  ||   |  .|.     |. .| |      .  . . .  .||    ...||  |    |.||..  || ...|...|.. ....  
pGslrienlkvdskadplfrvtklkl...vGgddeerflehwqgdvnnssdvyspl.rvlrklrnlsk....pvvvqdilGvskaatlvaieiallsllr

EGIV--DIFNFVRGMRFCRNYMVQTASQYDFLHHAIL
  |.   . . |  .|  |.. |... .| |..  .|
Gpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 408-575 4.6e-24 79.8 In-house 26-193 (297) alignment 
Range on Protein: 408-575
Range on HMM: 26-193/297.0
SIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGY--RQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVN
| |. .  | | | .. |  .| || |     ..||| | ||      .   .| .|||...|  |||..|.|    .|.|... .|.| .. . |||  
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

PNEEDMYGSFNVVALPEERA-LPDYIVRKFKLSHSknpDDSRTITHFQYINWPSTSCPKEATSMIDLVADV
 .|    |.. |  | .        |. ...| .    ..|| ..| |...||    | .   .  . |.|
vqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 543-652 2e-23 77.4 In-house 86-195 (440) alignment 
Range on Protein: 543-652
Range on HMM: 86-195/440.0
DDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEF
 .|||. ...|  ||  . || |  .. .. ||   | |.||||. |||| | ||||   |. ..|   |  . ||.|| ....| .|| .|.  .|| |
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHKAALEFVN
.|.| || . 
vheavlegll
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 180-360 1.2e-22 74.7 In-house 105-291 (302) alignment 
Range on Protein: 180-360
Range on HMM: 105-291/302.0
PDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPS--FGAANYGSFQVTLKEVETVAD-YA-IRTFQLQSL-----H-GQGPIKEVRQYHFLVWPDHGVP
  .| .| .|||  .. .....||.. || .|.     |  ..| . |. ..|.|  . ..  ..|.| ..     .  .   | |   .|  ||||| |
ekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGap

QYATPLLSFQKRVRNHHKGkpgpMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCR
. | . |   |    . |     ..||||||||||||...|   |     . . |. . |  .| ||   ||...|  .|   .  ..| .
keaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmek
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 387-651 1.1e-21 71.6 In-house 27-285 (302) alignment 
Range on Protein: 387-651
Range on HMM: 27-285/302.0
GFQSQFETLESSSPTDDDfdCSIAQlsDNLAKSRvKEHLPPNDYRVVLSTKNyDSDYICASYVDGYRQRSAFIATQGPMKNTA---GDFWRMVWEMKSMI
  ...|.....     .   |.. .  .||.|.. .|..|  | ..|  ...   .|..|| |.    .   | .| | ....    .|||||.. |   
evkkefkkidtmkvdlek..Ckafk..knlkknq.sedvpildsnlvkleae.pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

IIMLTNTEENGEeQSVQYWPVNPNEedmYGSFNVVALPEERaLPDYIVRKFKLSHSKNPDDS-R--TITHFQYINWPSTSCPKEATSMIDLVADVvRIQR
. .|  .||  .    ...| . ..   |  .. . .   .  .     |....    |..      ..     ||.... |.. ...|  .|.|   . 
vvilvgeeelkk.tlselfpkksgd...ykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakk

KSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
 ... .. .    | || |.| ......|.|....   .  .||..| |||  |. ..|| ... |.| ..
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
0048076 (Phosphotyrosine protein) phosphatases II 538-649 2.3e-21 71.4 In-house 37-141 (145) alignment 
Range on Protein: 538-649
Range on HMM: 37-141/145.0
HSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRKsGnGPITVHCSDGLGRTGTFCAMFTVLErlkaEQvIDVFSTVKTLRIQRPGFVNDI
 |  .. .|......|..||  ..|  .  ...... . ..... | ||. |||| |.|||||..|.. .|.    .. ........ .| ||||.|   
tselellerlgiqylylpwpDhgvpdllellleflefieealke.g.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp

DQYEFIHKAALE
.|..|.... ||
gqlrflyefele
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 124-360 7.4e-21 69.0 In-house 47-282 (303) alignment 
Range on Protein: 124-360
Range on HMM: 47-282/303.0
NHGKNRYVNIIPYDHSRVTLKpDgnpgSDYINASFIgGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFG-AANYGS
|  |||.|..|  |||.| |  |    | || ||..  |.| |  | || |.. .  |||.|| | .|  ....    | ||.  .  .|      ..  
nmdknrfvdvicldhskvkls.d....ssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfee

FQVT---LKEVETVADYAIRTFQLQslhgQGPIKE-VRQYHFLVWPDHGVPQYAT-----PLLSFQKRVRNHHKGKPgpMVVHCSAGVGRTGTFITIDTM
  .    .|.|| .  ....   .     .|  |  .  .|.  ||   .|  ..      .   |  .|.. ...|   |    .|.||.|||  ..| 
rsirvgefkrvelgdgwvlkvlsvs....ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstp..tvymslsgcgragtfalfeta

IMKIDAEG-IVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCR
 . . .|   .|. . .  .|  | . ||  ||. ...  . | ..  
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldn
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 293-357 1.9e-20 67.0 In-house 1-65 (69) alignment 
Range on Protein: 293-357
Range on HMM: 1-65/69.0
MVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
||||||.| |||||||.|   . .| .| .||||| |. || ||  ||    .| |.| |. ||.
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
0048179 (Phosphotyrosine protein) phosphatases II 541-645 4.9e-20 67.2 In-house 42-139 (144) alignment 
Range on Protein: 541-645
Range on HMM: 42-139/144.0
NPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVVRIQRksGNGPITVHCSDGLGRTGTFCAMFTVLerlkAEQvIDVFSTVKTLRIQRPGFVNDIDQY
...  |.........||  ..|  .. ...... . ....   .||. |||| |.|||||..|.. ..     .. ........ .| .||| |   .|.
pefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgql

EFIHK
.|...
rfLle
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 294-357 6.6e-20 65.2 In-house 1-64 (69) alignment 
Range on Protein: 294-357
Range on HMM: 1-64/69.0
VVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
|||||.| |||||||.|   . .| .| .||||| |. || ||  ||    .| |.| |. ||.
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 429-648 8.6e-20 66.0 In-house 32-256 (290) alignment 
Range on Protein: 429-648
Range on HMM: 32-256/290.0
DYRVVLS--TKNYDSDYICASYVDgYRQRSAFIATQGPMKN-------TAGDFWRMVWEMKSMIIIMLTNTEENGEEQSV----QYWPVNPNEEDMYGSF
. ||||    | . .||| |..|  . .  ..|.|| | ..       |  .|| |. . |.  ..|| . ||. ...|     .| | . .||  .. .
atrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgl

NVVAlPEERALPDYIVRKFKLSHSKNPddSRTITHFQYINWPSTSCPKEATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLK-AE
.|    .  .  | ..|.  . . ..     |.|| .. .| ... ...  ....|.  |     |  . |. ||| ||. |  .. |.      .   .
tvkC.kskekeddvetRelvvkfddee..eftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaets

QVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAAL
. . . . .|.|| ||   . .  .. |.  ...
gsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 441-657 2.3e-19 64.2 In-house 67-282 (312) alignment 
Range on Protein: 441-657
Range on HMM: 67-282/312.0
SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWP-----VNPNEEDMYGSFNVVALPEERAlPDYIVRKFK
  || | .|    .   |..||||..||.  ||...  . |  ||.|.   |.| |....|       |. ..  .|  .        ..  | |  .  
nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggks.kdkithrvl

LSHSKNPDDSRTITHFQYINWPSTSCPKEATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVN
    |   .   . |.|.  ||    |    .   |.. |     |  . |.  ||| |.|||||.. . ...  |.  .  .|  .   || .|   |.
kvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvr

DIDQYEFIHKAALEFVNTFDNY
 . || .  .. |||. .   |
vfpqyvyalrcvleflyskgly
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 179-357 6.1e-19 63.1 In-house 41-221 (255) alignment 
Range on Protein: 179-357
Range on HMM: 41-221/255.0
FPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLHG-QGPIKEVRQYHFLVWPDHGVPQYATPLLS
   |...|   .  ...|.....|... ||..|.|          .|..   ...||  .|| .. |  | .   ..|. |..  |...  |. |  .| 
vdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareiln

FQKRVRNHhKgkpgPMVVHCSAGVGRTGTFITID----TMIMKIDAEGIVD--IFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
  | ||.  |    ..|||||.|.||. .|. ..    .||. .|    |.    .... .|  |.  ..|  |  |    .|. .
ilkvvrds.k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 468-652 3.7e-18 60.5 In-house 40-222 (255) alignment 
Range on Protein: 468-652
Range on HMM: 40-222/255.0
TAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALPeerALPDYIVRKFKLSHSKN-PDDSRTITHFQYINWPSTSCPKEAT
|   |....   |.  ..||.. .|.| |.  .|.|.. .|  ..   ||..     .  | ..|  ..          .|..|..|  |.    |..| 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

SMIdlvaDVVRIQRKSgnGPITVHCSDGLGRTGTFCAMFTVLE----RLKAEQ--VIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFVN
 .      .... |.|   .. |||| | ||. .|  .  |       |.  .   .|  | .. || .|.. ...  |  |     |..| 
eil....nilkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 377-504 8.8e-18 59.1 In-house 13-152 (350) alignment 
Range on Protein: 377-504
Range on HMM: 13-152/350.0
KEIAPSSGKTGFQSqfeTLESSSPTDDDfDCSIAQLSDNLAKSRVKEHLPPNDYRVVLS-------TK---NYDSDYICASYVDGY----RQRSAF--IA
| | .  ...  ..   .|||.| .. . |  ...  .  || | |. || .  || |        .|      .||| |.|.       .. . |  ||
kliitknstvksrl...sLesdsespsn.DvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYia

TQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPV
||.|...|  ||.... . |  .|..||.  |.. |.  .||. 
tqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqe
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 124-357 1.1e-17 58.5 In-house 51-285 (302) alignment 
Range on Protein: 124-357
Range on HMM: 51-285/302.0
NHGKNRYVNIIPYDHSRVTLKpdgNPGSDYINASFIGGLNSPKDYIATQGPIPAAF---PDFWRMIWEYNVPTIIMVTNLKEDDKiKCHQYWP--SFGAA
|  ||.  ..  .|. .| |.   .   .|.||| .   .  .  | .| |.        .||||... .. .. ..   .| .|   ....|  |    
nlkknqsedvpildsnlvkle...aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyk

NYGSFQVTLKEVETVADYAiRTFQLQSL-HG--QGPIKEVrqYHFLVWPDHGVPQYATPLLSFQKRVRNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIM
.||.. |  . || . . .   . .  | .|  . .. .|  |..  |... ||.  . |    . | ...     ..|.    |.|| |.|.|  . . 
eygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanv..yvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

KIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
|....  . | . |. .|  |  .|....|| .|. |.|  |
klqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 410-646 9.1e-17 55.6 In-house 42-274 (303) alignment 
Range on Protein: 410-646
Range on HMM: 42-274/303.0
AQLSDNLAKSRVKEHLPPNDYRVVLStknyDSDYICASYVDGYRQRSAfIATQGPMKNTAGDFWRMVWEMKSMIII-MLTNTEENgEEQSVQYWPVNPNE
 |. .|. | |  . .  .  .| ||    || || |||..   .. | | || |.  || |||.|. | |   .. .||..| . .      .| | . 
nqfvknmdknrfvdvicldhskvkls....dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseyd.klggdsvfprnqdf

EDMYGSFNVVALPEERALPDYIVRKfkLSHSKNPDDSRTITHFQYINWPSTSCPKE-ATSMIDLVADVVRIQRKSGNGPITVHCS-DGLGRTGTFCAMFT
 ..   .  |    .  | |  | |  .    | |    .   .| .|| .| | . .  ..  . ..  . ||  ..  ||. |  | ||.|||. . |
lkfeersirvgefkrvelgdgwvlk..vlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfet

VLERLKAEQV-IDVFSTVKTLRIQRPGFVNDIDQYEFIHKA
    |..||  .|.   ....|  |   |... |. ...  
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl
subfamily_hpo-7_pd Subfamily hpo-7 467-651 1.3e-16 55.4 In-house 45-227 (263) alignment 
Range on Protein: 467-651
Range on HMM: 45-227/263.0
NTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALPEERalpDYIVRKFKLSH-SKNPDDSRTITHFQYINWPSTSCPKEA
.|   |....   |.  ..||.. .|.| |.  .|.|.. .|  ..   ||..        | ...  .|    ..    .|..|..|  |. .  |..|
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpela

TSMIdlvaDVVRIQRKSgnGPITVHCSDGLGRTGTFCAMFTVLE----RLKAEQ--VIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
 ...     .... |.|   .. |||| | ||.  |  . .|       |.  .   .|  | .. || .|.. ...  |  |     |.||
reil....nilkvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_CG42327_pd Subfamily CG42327 578-651 1.7e-16 54.8 In-house 241-315 (319) alignment 
Range on Protein: 578-651
Range on HMM: 241-315/319.0
IQRKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAE-QVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
  ... .||..|||||| ||||.  |    ...|.   . .|.  .|  .| .|   | ...|||||.| . |. 
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_eak_pd Subfamily eak 128-281 2.4e-16 54.0 In-house 56-206 (332) alignment 
Range on Protein: 128-281
Range on HMM: 56-206/332.0
NrYVNIIPYDHSRVTLKPDGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFG--AANYGSFQV
|  |.|.|||.  | | .       ||||| .   .  . || |  .     . ||.|. | . |.|... .  | .  |  .|.|  .    ..| ..|
n.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildv

TLKEVETVADYAIRTFQLQslHGQgPIKEVRQYHFLVWPDHGVPQYATpLLSFQKR
. ||    . .  | ..|.   |    ..|  |..  | .  .|.|   .|...| 
erkefvkrniletrllels..kGn.ethrvlhykvfGwtettlpkyed.flalrkv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 126-228 5.1e-16 52.9 In-house 50-166 (349) alignment 
Range on Protein: 126-228
Range on HMM: 50-166/349.0
GKNRYVNIIPYDHSRVTLKPDG---------------NPGSDYINASFI--GGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKC
 |||| .|.||.|||| ||                      ||||| ..    ..  | ||||| |.|..  ||...|   .|. .. ... || .  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HQYWPSfgaANYGSFQVTLK
..||      .| ...| |.
diywqe...lsysnitvklq
subfamily_hpo-7_pd Subfamily hpo-7 178-358 1.7e-15 51.7 In-house 46-228 (263) alignment 
Range on Protein: 178-358
Range on HMM: 46-228/263.0
AFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCHQYWPSFGAANYGSFQVTLKEVETVADYAIRTFQLQSLHG-QGPIKEVRQYHFLVWPDHGVPQYATPLL
. . |...|   .  ...|... .|... || .|.|          .|..   ... |  ..| .| |  | .  ...|..| .  |...  |. |   |
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

SFQKRVRNHhKgkpgPMVVHCSAGVGRTGTFITID----TMIMKIDAEGIVD--IFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIM
   | .||  |    ..|||||.|.||.  |  ..    .||. .|    |.    .... .|  |.  ..|  |  |    .|. ..
nilkvarns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 589-649 1.7e-15 51.1 In-house 2-62 (69) alignment 
Range on Protein: 589-649
Range on HMM: 2-62/69.0
VHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
|||| | |||||| |.   . |.|.|...|.|  |. .|  ||  | . ..| ||| |  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 588-649 1.9e-15 51.0 In-house 2-63 (69) alignment 
Range on Protein: 588-649
Range on HMM: 2-63/69.0
TVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALE
 |||| | |||||| |..  . |.|.|...|.|  |. .|  ||  | .  .| ||| |  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 462-642 6.3e-15 49.4 In-house 97-279 (302) alignment 
Range on Protein: 462-642
Range on HMM: 97-279/302.0
QGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALPEERALPDYIVRK-FKL-----SHS-KNPDDSRTITHFQYI
  | |.|   .| .. . .  |.. |..  |..|..  .|.  . ..|  .| . | ..  .  | ..  .| |||       . |. .  .|.  ... 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

NWPSTSCPKEATSMIDLVADVvriqrKSGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEF
 ||    |||| . .|..        .|    . |||| |.|||||. |.   ..  . ..| |. | |. .|  | | |.| .|  .
awpdhGapkeaytaldilkfc.....esykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 122-214 6.7e-15 49.4 In-house 94-180 (244) alignment 
Range on Protein: 122-214
Range on HMM: 94-180/244.0
PINHGKNRYVNIIPYDHSRVTLKpDGNPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDkikchQYWPS
| |  |||    .|.| .|| |   |. |  ||||||.| |    .|| || |.  .  |||.|. |  |  ....  ..|.|     .||| 
pnnswknregaglpfdfnrvpls.kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpd
subfamily_CG42327_pd Subfamily CG42327 283-353 1.6e-14 48.3 In-house 240-311 (319) alignment 
Range on Protein: 283-353
Range on HMM: 240-311/319.0
RNHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAE-GIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAI
|. .. . ||.||||| ||||||. |. |  | ...     ||| . |  .|  |   |.|  ||.|... .
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 414-560 1.6e-13 44.9 In-house 95-234 (244) alignment 
Range on Protein: 414-560
Range on HMM: 95-234/244.0
DNLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEeqsvqYWPVNpNEEDMYG
.|  |.|    || .  || ||  .    || ||.|    . . .| || |. .|. |||.|. | .  ....|   ||. |     |||   .  . | 
nnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpds.eplewye

SFNVVALPEERALPDYIVRKFKLSHSKNpDDSRTITHFQYINWPSTS
    |.| .   . .    ....    | .  ...| ||  ||||  
editvtltdrdefknikasnleiesdmn.eshqaltmfqisnwpsdg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 288-357 3.9e-13 43.9 In-house 226-295 (297) alignment 
Range on Protein: 288-357
Range on HMM: 226-295/297.0
GKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAI
 .. ...|||||||||.|  .  |... |.  . | |.  ... .|  |  .|||  |...|..|.|. .
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_eak_pd Subfamily eak 411-564 1.6e-12 41.5 In-house 48-197 (332) alignment 
Range on Protein: 411-564
Range on HMM: 48-197/332.0
QLSDNLAKSrVKEHLPPNDYRVVLS-TKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEE
.  ... .  | . .| . | | |. ..     || || ..       .| |  . ..    ||.|| | ||  |..| .  |.. |.| .|.| .  ||
arleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

DMYGSFNVVALPEeRALPDYIVRKFKLSHSknpDDSRTITHFQYINWPSTSCPKE
  .| ..|           . .|...||     ...  . |...  |  |. || 
lkfGildverkef.vkrniletrllelskG...nethrvlhykvfGwtettlpky
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 80-173 2.5e-12 40.8 In-house 4-95 (95) alignment 
Range on Protein: 80-173
Range on HMM: 4-95/95.0
PLNVSDFIEMMALLQSNNSDRLEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDgnPGSDYINASFIGGLNSPKDYIATQG
|. || |   .  ..||  . ...|.  | .    .  .     |  |||..||.||| .||.|       |||||| |. |    . |||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttk..rdsdyinacfvdgyarkncyiaaqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 80-164 1.1e-11 38.7 In-house 5-88 (440) alignment 
Range on Protein: 80-164
Range on HMM: 5-88/440.0
PLNVSDFIEMMalLQSNNSDRLEEEYPDIELEWNFTSYAAKLPINHGKNRYVNIIPYDHSRVTLK-PDGNPGSDYINASFIGGLNS
|. |.|| ...   ..  |   |.|.  .       |  | || |. |||| ||. |||||| |.   | | |||||||.| |..|
piivadfadyv..qnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 582-651 1.6e-11 38.6 In-house 226-295 (297) alignment 
Range on Protein: 582-651
Range on HMM: 226-295/297.0
SGNGPITVHCSDGLGRTGTFCAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
  | .. |||| |.||.|      ..|..|. ... || . .. || ||.  |. ..|.|....|.|. .
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 167-244 2e-11 37.9 In-house 237-312 (440) alignment 
Range on Protein: 167-244
Range on HMM: 237-312/440.0
DYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKedDKiKCHQYWPSFG-AANYGSFQVTLKEVETVADYAIRTFQLQ
 .|||| |. ..  ||||.. .|.. ||||. .|.  ||  |  |||    .  .| | |  |  | .    .||..|.
afiatqmpldstvldfwrlvhdyristiimlnqln..dk.tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk
I-set Immunoglobulin I-set domain 2-66 2.2e-11 35.4 Pfam-A 22-90 (90) alignment 
Range on Protein: 2-66
Range on HMM: 22-90/90.0
CESTGTPAPTISWHKEGMILEEPDYVQFN-DG---SLYITNTKLKDQGHFIVRATNNIGVVEETVRVTV
|. .|.| |..||.|.|  |.. . |... ..   .| |.| . .|.| . ..|||..| .|......|
ctveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 136-364 2.2e-11 38.5 In-house 30-257 (290) alignment 
Range on Protein: 136-364
Range on HMM: 30-257/290.0
YDHSRVTLKPDGNP-GSDYINASFIGgLNSPKDYIATQGPIPAA-------FPDFWRMIWEYNVPTIIMVTNLKEDDKI----KCHQYWPSFG--AANYG
  ..|| ||  |.   .||| |...    .    |.|| |  .          .|| |. . .|  ..|. . .| ..      | .| |       ...
veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

SFQVTLKEVETVADYAIRTFQLQslHGQGPIKEVRQYHFLVWPDHGVPQYATPLLSFQKRVRNHHkgkpGPMVVHCSAGVGRTGTFITIDTMIMKID-AE
 ..|  |. |.. |  .|.  ..  ....    |  . .  | .  |..    |||  . |....     |..|||  |. |  .. .|.    ||   .
gltvkCkskekeddvetRelvvk..fddeeeftvtHsllkgWnklnvqedtktllsliqkvkask....tpvivHcvdGiSrsAalaaiilgyQkiaets

GIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILeaimcrdttI
| | . . .  .|  |. ....| .. |   .|.         .
gsvkledvlkalrkqralaitsalelafvdagiv.........l
0038934 (Phosphotyrosine protein) phosphatases II 550-640 2.4e-11 39.1 In-house 79-172 (194) alignment 
Range on Protein: 550-640
Range on HMM: 79-172/194.0
HFQYINWPS---TSCPkEATSMIDLVADVVRIQRKSGNGPITVHCSDGLGRTGTFCAMFTVL-ERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQY
 ..|...|     ..|     . . .  | .. ... .| . |||  |||||||..| . .   ...||. |. |. ..   |......... ..
gieylklpfpddgtvP.sleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 125-209 3.3e-11 37.3 In-house 38-128 (347) alignment 
Range on Protein: 125-209
Range on HMM: 38-128/347.0
HGKNRYVNIIPYDHSRVTLKPDG------NPGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDKIKCH
  |||  .    | .|| | |.       ..   ||||| |   |. |.|| || |.| .  |||.|.   .|  .. . . ..|. |.  
lsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaieef
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 450-517 3.5e-11 37.1 In-house 230-293 (440) alignment 
Range on Protein: 450-517
Range on HMM: 230-293/440.0
DGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEEngEeQSVQYWPVNPNEeDMYGSFNV
.|| .. |||||| |.  |  ||||.| . .   |||| . ..        |||||      .| | |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd..k.tcsiywpvntrs.vtfgpftv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 414-534 3.6e-11 37.1 In-house 33-153 (332) alignment 
Range on Protein: 414-534
Range on HMM: 33-153/332.0
DNLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKN-TAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMY
.|.   |.      .  || |. ..   |.  ||.|||| ..||.| .| |... |   ||||| | |  .|... . .|. . ..         |. . 
nnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksfl

GSFNVVALpEERALPDYIVRKF
  |   .| ||  |   |.|||
hefgaksl.eecelkakicrkf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 284-354 5.3e-11 36.8 In-house 255-341 (350) alignment 
Range on Protein: 284-354
Range on HMM: 255-341/350.0
NHHK-GKPGPMVVHCSAGVGRTGTFITIDTMIM-------------KIDAEG-IV-DIFNFVRGMRFCRNYMVQTASQYDFLHHAIL
.| .  .  |..||||||||||||..|.| ..              |.|    .   |.  |  .|  |  |||.  |. |...|.|
shldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 134-226 8.1e-11 36.4 In-house 3-83 (130) alignment 
Range on Protein: 134-226
Range on HMM: 3-83/130.0
IPYDHSRVTlkpdgnpGSDYINASFIGGLNSPKDYIATQGPIPAAFPDFWRMIWEYNVPTIIMVTNLKEDDkikchQYWPSFGAANYGSFQVT
.... ||.        | .||||||.| |.  ..|. || |. ..  |||.|. |  |  ....  ..|.|     .|||     ..   ...
lefevsrlq.......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeedii
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 547-650 1.1e-10 35.8 In-house 216-343 (350) alignment 
Range on Protein: 547-650
Range on HMM: 216-343/350.0
TITHFQYINWPST---SCPKEATSMID----LVADVV-R-IQRKSGNGPITVHCSDGLGRTGTFCAMFTVLE------RLK--------AEQVID-VFST
 . ..|. ||.       |..  ....    |. | . .    ..   || |||| | |||||....  .|.       |.        | .. | .. .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKTLRIQRPGFVNDIDQYEFIHKAALEF
|. || ||   | ..||. ||..|.| .
vnelrkqrismvqnldqfifiYeallfy
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 440-560 2.4e-10 34.8 In-house 12-125 (130) alignment 
Range on Protein: 440-560
Range on HMM: 12-125/130.0
DSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEeqsvqYWPVNpNEEDMYGSFNVVALPeERALPDYIVRKFkLSHS
. .|| ||.|    . . .. || |. .|. |||.|. |    ....|   ||. |     |||   .  . |    .|.|  .|   ..|  .. |  .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpds.ePlewyeediivtlt.drdefknikasn.leie

KNPDD-SRTITHFQYINWPSTS
..  .  ...| ||  ||||  
sdlneshqaltmfqisnwpsdg
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 409-463 1e-09 32.5 In-house 42-95 (95) alignment 
Range on Protein: 409-463
Range on HMM: 42-95/95.0
IAQLSDNLAKSRVKEHLPPNDYRVVLSTKNyDSDYICASYVDGYRQRSAFIATQG
.     |. | |. . .| .  ||||.||  ||||| | .|||| .. ..||.||
vgsseanipknrflnifpydatrvvlttkr.dsdyinacfvdgyarkncyiaaqg
0038934 (Phosphotyrosine protein) phosphatases II 254-349 1.3e-09 33.5 In-house 78-169 (194) alignment 
Range on Protein: 254-349
Range on HMM: 78-169/194.0
EVRQYHFLVWPDHGVPQYATPLLSFQKRVRN-HHKGKPGPMVVHCSAGVGRTGTFITIDTMI-MKIDAEGIVDIFNFVRgmrfcrNYMVQTASQYDFL
   .|. | .||.|..     ||.| . |   ... ..|  .||| ||.|||||..    .  ....||  ...|...|      . .... .... |
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR......pgaipnqdyleal
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 406-492 6e-09 29.9 In-house 28-123 (347) alignment 
Range on Protein: 406-492
Range on HMM: 28-123/347.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD-------SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTN--TEE
... ..   .|.| | |..   .. ||||| .. .         || ||..     .  .| || |. .|  |||.||  .|   .. . .  ..|
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikde
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 289-355 1.4e-08 28.4 In-house 264-342 (349) alignment 
Range on Protein: 289-355
Range on HMM: 264-342/349.0
KPGPMVVHCSAGVGRTGTFITIDTMIM----------KIDAEGIV--DIFNFVRGMRFCRNYMVQTASQYDFLHHAILE
.  ...|||||| ||||...|.| ..           ||. . .    |.  |  .|  |  |||  .|......|.|.
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_CDC14_pd Subfamily CDC14 571-643 1.7e-08 28.7 In-house 251-317 (328) alignment 
Range on Protein: 571-643
Range on HMM: 251-317/328.0
LVADVVRIQRKSgNGPITVHCSDGLGRTGTFCAMFTVLE-RLKAEqvidvfSTVKTLRIQRPGFVNDIDQYEFI
.|   ..|  |. .| |.|||  |||||||. | . . . |. |.       ..  ||| ||| |    |  ..
ivkkfleiaeka.eGaiavhCkaGLGrtGtLiacylmkhyrftaa......eaiawlricrPGsvigpqqkfle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 439-503 2.3e-08 27.8 In-house 88-154 (349) alignment 
Range on Protein: 439-503
Range on HMM: 88-154/349.0
YDSDYICASYVDGYR--QRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWP
   ||| | |.   |      .|||| |.  |  ||....   .  ... |.. .|.. |.  .|| 
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 123-208 3.9e-08 27.1 In-house 33-118 (332) alignment 
Range on Protein: 123-208
Range on HMM: 33-118/332.0
INHGKNRYVNIIPYDHSRVTLKPDGNpGSDYINASFIGGLNSPKDYIATQGPIPAAF-PDFWRMIWEYNVPTIIMVTNLKEDDKIKC
 |   ||   .  .||||| | |.     |. |||.. | .    || .| |.       ||||. | .   |... .. | .| |.
nnmdmnriphlycfdhsrvelapqdg.kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 113-214 5e-08 26.1 In-house 16-86 (169) alignment 
Range on Protein: 113-214
Range on HMM: 16-86/169.0
NFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINAsfigglnspkdyiatqgpipaafpdfwRMIWEYNVPTIIMVTNlkEDDKikcHQY
..  . |.| .|. |||    .   | || |.    . |||||||                           ||||| |   |... .   |||    ..
eynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgd..tddk...nnf

WPS
|| 
wpe
subfamily_PTPDC1_pd Subfamily PTPDC1 569-641 6.4e-08 27.2 In-house 98-172 (182) alignment 
Range on Protein: 569-641
Range on HMM: 98-172/182.0
IDLVADVVRIQRK-SGNGPITVHCSDGLGRTGTFCAMFTVL-ERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQYE
.. . |.|..      .| ..|||  ||||||   | . |  .||.||. |..    ..  ||  . |. . ...
leriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefa
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 581-651 7.1e-08 26.1 In-house 262-344 (349) alignment 
Range on Protein: 581-651
Range on HMM: 262-344/349.0
KSGNGPITVHCSDGLGRTGTFCAMFTVLE---RL---------KAEQVIDVFSTVKTLRIQRPGFVNDIDQYEFIHKAALEFV
..   .. |||| | ||||... .  .|.    |         .| .   .. .| .|| ||   |... |. .|..| |...
tdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_eak_pd Subfamily eak 284-364 7.4e-08 26.1 In-house 230-312 (332) alignment 
Range on Protein: 284-364
Range on HMM: 230-312/332.0
NHHKGKPGPMVVHCSAGVGRTGTFITIDTMIMKIDAE--GIVDIFNFVRGMRFCRNYMVQTASQYDFLHHAILEAIMCRDTTI
 .|       .. .. |  |.|.|. || .|  ||.       . ...  ..  |.. | .| |. |.....|. .. |.  .
yihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrl
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 113-214 7.7e-08 25.3 In-house 15-85 (169) alignment 
Range on Protein: 113-214
Range on HMM: 15-85/169.0
NFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKP-DGNPGSDYINAsfigglnspkdyiatqgpipaafpdfwRMIWEYNVPTIIMVTNlkEDDKikcHQY
..  . |.| .|  |||    .   | || |.    . |||||||                           ||||| |   |... .   |||    ..
eynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGd..tddk...nnf

WPS
|| 
wpe
ig Immunoglobulin domain 2-45 1.5e-07 22.7 Pfam-A 8-58 (64) alignment 
Range on Protein: 2-45
Range on HMM: 8-58/64.0
CES-TGTPAPTISWHKEGMILEEPDYVQFNDGS------LYITNTKLKDQG
|.. .|.| ...|| |||  |||...... . .      | |.|..  | |
CsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsG
subfamily_DSP23_pd Subfamily DSP23 572-645 3.2e-07 25.1 In-house 70-140 (148) alignment 
Range on Protein: 572-645
Range on HMM: 70-140/148.0
VADVVRIQR--KSGNGPITVHCSDGLGRTGTFCAMFTVLERlkaeqVIDVFSTVKTLRIQRPGFVNDIDQYEFIHK
| . ||.    .. |  ..|||  | |||||. | . | ||      .    ..  .| .||| |. ..| . ...
vvefvrvveeaeekneavsvhcllgrgrtgtmlacylvker.....klaaaeaiaevrrlrpgsvetveqeklvrd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 113-156 5.3e-07 23.5 In-house 28-71 (244) alignment 
Range on Protein: 113-156
Range on HMM: 28-71/244.0
NFTSYAAKLPINHGKNRYVNIIPYDHSRVTLKPDGNPGSDYINA
.|    | |  |  ||||.||.|.|..|| |    . |||||||
eflqtnavlsanatknryinilpfdetrvilssskkegsdyina
PTEN_1 550-622 7.5e-07 24.1 In-house 94-169 (196) alignment 
Range on Protein: 550-622
Range on HMM: 94-169/196.0
HFQYINWPSTSCPKEATSMIDLVADVVRIQRK--SGNGPITVHCSDGLGRTGTFCAMFTVLER-LKAEQVIDVFST
...|.. | . ...   |..  .....  ...  . .. . |||  ||||.|| .|.. .  . | |.. .. .  
gveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvre
0048567 (Phosphotyrosine protein) phosphatases II 551-642 1.3e-06 22.9 In-house 33-130 (157) alignment 
Range on Protein: 551-642
Range on HMM: 33-130/157.0
F------QYINWPSTSCPKEATSMIDLVADVVRIQR--KSGNGPITVHCSDGL---GRTGTFCAMFTVLE-RLKAEQVIDVFstvktlRIQRPGFVNDID
|      .|...     | . .  ....  . .. .  .  ...| |||. ||   |||.|... . .|  .. .|..|. .      || |||.|   |
FsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiapl......rivrpgsvpfrd

QYEF
.. .
asyl
Ig_2 Immunoglobulin domain 1-66 1.7e-06 20.0 Pfam-A 20-80 (80) alignment 
Range on Protein: 1-66
Range on HMM: 20-80/80.0
MCESTGTPAPTISWHKEGMILEepdyV---QfndgsLYITNTKLKDQGHFIVRATN-NIGVVEETVRVTV
.|...| |.|...| |.| .|.        .     |.| |. ..|.|..  ||.| . . . ..|.|||
tCqapgnptpkvqwykdgeels....qsqna.....lfipnvsaedsGtYtCrasnsegskqsnsvevtv
subfamily_DSP11_pd Subfamily DSP11 566-639 2.1e-06 21.8 In-house 99-172 (178) alignment 
Range on Protein: 566-639
Range on HMM: 99-172/178.0
TSMIDLVADVVRIqRKSGNGPITVHCSDGLGRTGTF-CAMFTVLERLKAEQVIDVFSTVKTLRIQRPGFVNDIDQ
..... | . .   .|  .  |.||| .|. ||| . |  .   | ...|. |..|....   ..|  ...|. .
kkfkeavkeflek.nkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkk
subfamily_CDC14_pd Subfamily CDC14 288-349 2.2e-06 21.8 In-house 261-316 (328) alignment 
Range on Protein: 288-349
Range on HMM: 261-316/328.0
GKPGPMVVHCSAGVGRTGTFITIdtMIMKIDAEGIVDIFNFvrgMRFCRNYMVQTaSQYDFL
   | ..||| ||.|||||.|.    .||       ..  .   .|.||  .| .  |  ||
kaeGaiavhCkaGLGrtGtLiac..ylmkhyrftaaeaiaw...lricrPGsvig.pqqkfl
DSPc Dual specificity phosphatase, catalytic domain 545-638 3.4e-06 22.0 Pfam-A 34-128 (133) alignment 
Range on Protein: 545-638
Range on HMM: 34-128/133.0
SRTITHFQYINWPSTS-CPKEATSMIDLVADVVRiQRKSGNGPITVHCSDGLGRTGTFCAMFTVL-ERLKAEQVIDVFSTVKTLRIQRPGFVNDID
... ....|.. |      .. .. .. . .... . .. .. . |||  |. |..|.....    ..|.... .....  .    .. ||.  . 
aikkseieylripvedetetkiskeleeavefie.kaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLl
DSPc Dual specificity phosphatase, catalytic domain 545-638 3.4e-06 22.0 In-house 34-128 (133) alignment 
Range on Protein: 545-638
Range on HMM: 34-128/133.0
SRTITHFQYINWPSTS-CPKEATSMIDLVADVVRiQRKSGNGPITVHCSDGLGRTGTFCAMFTVL-ERLKAEQVIDVFSTVKTLRIQRPGFVNDID
... ....|.. |      .. .. .. . .... . .. .. . |||  |. |..|.....    ..|.... .....  .    .. ||.  . 
aikkseieylripvedetetkiskeleeavefie.kaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLl
PTPc_motif_SM00404 549-624 5.8e-06 21.2 In-house 45-121 (140) alignment 
Range on Protein: 549-624
Range on HMM: 45-121/140.0
THFQYINWPSTS-CPKEATSMIDLVADVVRiQRKSGNGPITVHCSDGLGRTGTFCAMFTVL-ERLKAEQVIDVFSTVK
 .||... |      .. .  .| |.|... . .. .| . |||  |. |..|.....    . |..........  .
sgfqilqiplddnekdklskyldkvldfie.naekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR
Ig_3 Immunoglobulin domain 2-53 6e-06 18.4 Pfam-A 22-75 (75) alignment 
Range on Protein: 2-53
Range on HMM: 22-75/75.0
CESTGTP-APTISWH-KEGMILEEPDYVQFNDGSLYITNTKLKDQGHFIVRATN
|...|.| .|||||  .....|. ...   ....| |.... .| | . . |.|
CsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_PTEN_pd Subfamily PTEN 275-350 7.9e-06 21.0 In-house 98-173 (184) alignment 
Range on Protein: 275-350
Range on HMM: 98-173/184.0
LLSFQKRVRNHHKGKP-GPMVVHCSAGVGRTGTFITIdTMIMKIDAEGIVDIFNFVRGMRFCRNYMVQTASQYDFLH
| .. . .... . ..   .|||| || ||||. |.   .. .   |   .. ..   .|.  .  |.  ||  ...
leeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYve
subfamily_PTPDC1_pd Subfamily PTPDC1 258-350 8.8e-06 20.3 In-house 85-169 (182) alignment 
Range on Protein: 258-350
Range on HMM: 85-169/182.0
YHFLVWPDHGVPQYATpLLSFQKRVRNHHKgkPGPMVVHCSAGVGRTGTFITIDTMI-MKIDAEGIVdifNFvrgMRFCRNYMVQTASQYDFLH
.. . |.|.||.   . .|   | |    .   | . ||| || ||||  |.   .   ...||  .   ..   .|  |   .|| .| ....
vynfgwkDygvasler.iLdivkvvafalq..egkvavhChaGlGrtGvliacylvyakrltaekai...kl...vrskrpksiqtreqvelvk