Gene PTPRD-10 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP063_AA protein Get Run
AqueP063_AA_697-874 phosphatase_domain Get Run
AqueP063_AA_867-1097 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 862-1097 7.1e-142 466.5 In-house 27-264 (287) alignment 
Range on Protein: 862-1097
Range on HMM: 27-264/287.0
KVLEQVTQRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQE
.||||||||.|||||||||||.|.|||.|.|.||||||.||||||||||||||.||||||||||||||||||||||||.|||||||||||||||.|||.|
tvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendee

VCYQYWSNGK---LGEYNISLLNEEiHNAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRS
||||||...|   ||||||.||||| .||||||||.||.|.||||||||||||||||||||||.|.||||||||||||.|||||||||||||||||||||
vcyqyWpeeksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

AMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|||||||||||||||||||||||||||||||||||||||
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 866-1097 3.2e-112 369.1 In-house 30-269 (290) alignment 
Range on Protein: 866-1097
Range on HMM: 30-269/290.0
QVTQRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLK--GEHPD----YINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENEND
...... .||....|.|. .|| ......|..|..|.  ..|.|    ||||..|.||||||..|....|..||...|||.|....||.||||....|..
dsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieeg

QEVCYQYWSNG---KLGEYNISLLNEEIHNaGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVG
...|.|||..    ..||..| |||||..| .|||||.||.|.|.||.||.|.||||||||||||.||||||||||||||.|||||||||||||||||||
kvkCqqYWpdsdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvg

RSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|||.|||||||||||||||||||||||||||||||||||||
rsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 694-866 5.1e-94 309.4 In-house 1-173 (290) alignment 
Range on Protein: 694-866
Range on HMM: 1-173/290.0
MIPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDCTNEYINACYIKDYSNQYQYIATQGPV
.|||||||||||.|||||||||||||.|||||||.||||||||.|||||||||||||||||||||||.|||||||||||||||||.|....|||||||||
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

SNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQ
||||||||.|||||...||||.|||||||| ||||||||||||.||.||..|..|..|..|. ||..||  ..
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknkns
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 694-862 8.8e-66 216.8 In-house 1-164 (287) alignment 
Range on Protein: 694-862
Range on HMM: 1-164/287.0
MIPVDKFGEFVAKGHAKGNEGFRNQFGMLDS-GESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYIKDYSNQYQYIATQGP
.|||.|||||||||||||||||.||| .|.. ..... ||......|| .||...|.|.|..|. |.      .. ..||||..|. |......|....|
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

VSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVK
..||...||.||....  .|||...  |. . .| ||||....  .|.....| .|.| ..|..||..||
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 869-1096 1.2e-64 213.4 In-house 35-268 (305) alignment 
Range on Protein: 869-1096
Range on HMM: 35-268/305.0
QRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKGEHP--DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQY
. . .|... |.....|.. .. |..| ...  | ...  ||||| ...|||.||..|.| .|. || ..||..| .  |. ||||..  |.... |.||
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

WSNG-----KLGEYNISLLNEEiHNAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMF
| .      ..||... | .|. . ..|||||........  ....| |||.|.|   |  . . ..| .|... ..|.|  .....||||..|||. .|
Wpesktekkefgefsvelksek.tasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvf

CAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|    ....|.|.|.|||.|||  | .... |||
iavdialerlkkEevvdvfevlkqlRskrmkmvqt
0050432 (Phosphotyrosine protein) phosphatases II 871-1097 9e-61 201.2 In-house 57-285 (308) alignment 
Range on Protein: 871-1097
Range on HMM: 57-285/308.0
PDEVTHNIASQNNDRNRLNQFLPPDNYRVPLkGEHPDYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYW-
. | ..    .| |.||   .|| |. || | .|. ||||| ...||  | ...||.. .|. ||  .||.|. . ||. ||||... ||..| |.||| 
lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwp

-----SNGKLGEYNISLLNEEIhNAGYIERKIEVTNDNKAgDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQrkrGNTSIVVHCSDTVGRSAMFC
     .  . | . . ||.||. ...|. |..|.|| ..  .  .|.... |||   |  ..|. .|  .|.. ...   ..  ||||||. |||.. |.
lelgggsleygkftvtllseev.lddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfi

AAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|. . ..  ..|| .|||...|  | |.||.|||.
aldllleqlekeggvdvfeavkklReqRpgmvqtp
0036941 (Phosphotyrosine protein) phosphatases II 873-1097 1.3e-59 197.3 In-house 30-263 (297) alignment 
Range on Protein: 873-1097
Range on HMM: 30-263/297.0
EVTHNIASQNNDRNRLNQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG--
. .. .  .| ..||   .|| |. || |..|. ||||| ...||. |..||... |. ||  .||.|. . ||| ||||... |.. | |.|||..   
slsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeg

---KLGEYNISLLNEEIH-NAGYIERKIEVTNDnKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAA
   . |.. . ||..|.. ...|. |..|||.  . |.. .|.....|.|.  |  ..|...|  ||.. . ...  ... ..||||. ||||..|.|| 
esltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaad

TTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTV
. ..  .   .|| .|.....|. | |.||.|||.
lmlqqledklkeggvdileavkklReqRpgavqtl
0046845 (Phosphotyrosine protein) phosphatases II 873-1097 4.4e-59 195.5 In-house 19-260 (284) alignment 
Range on Protein: 873-1097
Range on HMM: 19-260/284.0
EVTHNIASQNNDRNRLNQFLPPDNYRVPLKG-----EHPDYINAVFINGY-----KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEV
.... .. .| ..||  ..|| |. || ||      |. ||||| ...||     . ||.||..  |. ||  .||.|. . ||. ||||... ||..| 
slsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrek

CYQYWSNGK----LGEYNISLLNEEIhNAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK-RGNTSIVVHCSDTVGR
|.|||.. .    .|.. . ||.||. . .|. |..|.|| .  |   .|.....|.|   |  ..|. .|  .... . ...  |.  ||||||. |||
caqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgR

SAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTV
...|.|. . ..  ..||   ..||....|  | |.||.|||.
tGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0047943 (Phosphotyrosine protein) phosphatases II 871-1096 1.1e-58 194.3 In-house 27-257 (273) alignment 
Range on Protein: 871-1096
Range on HMM: 27-257/273.0
PDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG
. . .. .  .| |.||   .|| |. || |.... ||||| ...||. |..||... |. ||  .||.|. . ||. ||||... |...| |.|||.. 
lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwple

------KLGEYNISLLNEEIhNAGYIERKIEVTNDNKAGdKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCA
      . |.. . ||.||. ...|. |..|.|| .    . .|.... |.|   |  .... .|  ||.. .....  .|. .|||||. |||...|.|
ggelsltygkftvtllseet.kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfia

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
. . ..  ..|| .||....|  | |.||.|||
ldllldqlekeggvdvleavkllrsqRpgmvqt
0051299 (Phosphotyrosine protein) phosphatases II 872-1097 1.2e-58 194.2 In-house 39-272 (288) alignment 
Range on Protein: 872-1097
Range on HMM: 39-272/288.0
DEVTHNIASQNNDRNRLNQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYW
 .... .  .| ..||   .|| |. || |.     |. ||||| .|.||. |..||... |. ||  .||.|. . ||. ||||... |...| |.|||
ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYw

SNG---KLGEYNISLLNEEIhNAGYIERKIEVTNDN---KAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMF
..|   ..|.. . ||.||. ...|. |..|||| .   . | ...|.... |||   |  ..|. .|  ...... ..  |.  .|||||. |||...|
plggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtf

CAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|. . ..  ..||..||....|  | |.||.|||.
ialdllleqlekeggvdvleavkrlreqRpgmvqtp
DSPc_SM00195 869-1096 2.7e-57 189.5 In-house 15-247 (263) alignment 
Range on Protein: 869-1096
Range on HMM: 15-247/263.0
QRpdEVTHNIASQNNDRNRLNQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCY
..  |.|... ..|...|| ...|| |. || || |.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||..|.||..| |.
pk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

QYWSNG-----KLGEYNISLLNEEIHNAGYIERKIEVTNDNKaGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVGRSA
.|| .      . |.... | ..|.... .| |..|.|...|  ....|.|||..||   |   ... .| ...... ....  .. ||||||. |||..
rywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtg

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|... . ..|...|  .|.|...|. | |.||.|||
tfvtidiilskleeekkvdifeivkelRkqRpgmvqt
PTPc_SM00194 869-1096 2.7e-57 189.5 In-house 15-247 (263) alignment 
Range on Protein: 869-1096
Range on HMM: 15-247/263.0
QRpdEVTHNIASQNNDRNRLNQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCY
..  |.|... ..|...|| ...|| |. || || |.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||..|.||..| |.
pk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

QYWSNG-----KLGEYNISLLNEEIHNAGYIERKIEVTNDNKaGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVGRSA
.|| .      . |.... | ..|.... .| |..|.|...|  ....|.|||..||   |   ... .| ...... ....  .. ||||||. |||..
rywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtg

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|... . ..|...|  .|.|...|. | |.||.|||
tfvtidiilskleeekkvdifeivkelRkqRpgmvqt
0045450 (Phosphotyrosine protein) phosphatases II 868-1096 4.6e-57 189.4 In-house 41-289 (307) alignment 
Range on Protein: 868-1096
Range on HMM: 41-289/307.0
TQRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKG-----EHPDYINAVFI--------NGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQ
.. ..| ..    .| |.||   .|| |. || |.      |. ||||| ..        .||. |..||.. .|. .|  .||.|. . .||.||||..
vfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmlte

ENENDQEVCYQYWSNG----KLGEYNISLLNEEIhNAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKR-GNTSIVV
. |...| |.|||..       |.. . ||.||.  .||. |..|||. .. |   .|.... |.|  .|  ......|  |||. . ...  ... ..|
lvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlV

HCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQT
|||. |||...|.|| . .   ..||.   .|.....|  | |.||.||.
HCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqn
subfamily_PTPRD_pd Subfamily PTPRD 695-866 5.8e-57 188.6 In-house 5-173 (564) alignment 
Range on Protein: 695-866
Range on HMM: 5-173/564.0
IPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGeSDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDCtnEYINACYIKDYSNQYQYIATQGPVS
|||... |.||| .|...  | ...  ...| . .|...   | ||  ||.|||| || .|. |... |....  .|||| .|. | .. .|||||||..
ipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPla

NTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQ
.|. ||||..|...|..|||.|.. |.|| ||..|||...|. || . |||..|. |.||..|.. .|  ..
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkks
Y_phosphatase Protein-tyrosine phosphatase 882-1096 7.6e-57 187.8 Pfam-A 1-222 (235) alignment 
Range on Protein: 882-1096
Range on HMM: 1-222/235.0
NNDRNRLNQFLPPDNYRVPL--KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWS-----NGKLGE
| ..|| ...|| |. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....|...| | |||.       . |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YNISLL-NEEIHNAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
... |  .|. ....|. ||.|......  .|..|||...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQT
|. .||.|..|. | |.||.||.
eeevdvlqivkelRkqRpgmvqs
Y_phosphatase Protein-tyrosine phosphatase 882-1096 7.6e-57 187.8 In-house 1-222 (235) alignment 
Range on Protein: 882-1096
Range on HMM: 1-222/235.0
NNDRNRLNQFLPPDNYRVPL--KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWS-----NGKLGE
| ..|| ...|| |. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....|...| | |||.       . |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YNISLL-NEEIHNAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
... |  .|. ....|. ||.|......  .|..|||...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQT
|. .||.|..|. | |.||.||.
eeevdvlqivkelRkqRpgmvqs
0040438 (Phosphotyrosine protein) phosphatases II 869-1096 9.2e-57 188.1 In-house 30-261 (317) alignment 
Range on Protein: 869-1096
Range on HMM: 30-261/317.0
QRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCY
. .|. .. .  .| |.||   .|| |. || |. .      ||||| ...|...|..||.. .|. ||  .||.|. . .|| ||||... |...| |.
lkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekca

QYWSNG---KLGEYNISLLNEEIhNAGYIERKIEVTNDnKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMF
|||..|   . |.. . ||.||  .||.. |..||... . ... .|.... |.|.  |   .|...|  .|.. . .. .... ..||||. |||...|
qYwplgetltygdftvtllseee.lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtf

CAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|| . .. ...|| .||....|  | |.||.|||
iaaylmleqlekeggvdveeavkelreqRpgavqt
subfamily_PTPRD_pd Subfamily PTPRD 873-1096 1.2e-56 187.6 In-house 39-266 (564) alignment 
Range on Protein: 873-1096
Range on HMM: 39-266/564.0
EVTHNIASQNNDRNRLNQFLPPDNYRVPLK----GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWS
....  ...|  .||... .. |. || |.     |  ||||| ||.||...||.| .  |. .| ..||.|. ..|.. |||| . .|.... | .|| 
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

NG---KLGEYNISLLNEEiHNAGYIERKIEVtNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAA
.    . ||. ..| .|| . | |. |.... ...|  ....|.|.. |.| ..| .......| .|... ... ....  ||||||  |||. .|..  
ekgtetygeltVtleeee.eladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivid

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
  ... |.|...|..|..|  | |..  |||
amlerikeektvDiyqyvkalrkqRnamVqt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 857-1096 1.9e-56 186.0 In-house 8-251 (283) alignment 
Range on Protein: 857-1096
Range on HMM: 8-251/283.0
RKMHVKVLEQVTQRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKGEHPDYINAVFIN---GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
 |.. .||....  . ... . |..|.  || .. .| |..|| || | .||||||||     ||..| .||| ||. .| ..||||. |...|||||| 
nklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

QENENDQEVCYQYWS-NG--KLGEYNISLLNEEIHNaGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTiLLVIEEMYRTQRKRGNTSIVVH
.  |. .. | |||  .|  . ||. ..| .|  .|  .| ... . ... | ..  .  ||. .| . |. .   . |. .. .   |..  .. ||||
klqedlrikCsqyWPkrGsedyGeftvtlrkettsn.sfiikelllrvnssakstlllahyqvidWleygeqaiins.lvkfnkvislqteskkgPivvh

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
|| ..||.|.|.||...... .|| |.|||.|.|  | |... |||
CstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 864-1096 7.6e-56 184.5 In-house 36-275 (298) alignment 
Range on Protein: 864-1096
Range on HMM: 36-275/298.0
LEQVTQRPDEVTHNI--ASQNNDRNRLNQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENE
|..|... .| ....  ...|...||  . .. |  || |.     |. |||||.|...||...|||... |. .|  .||.|. ......|||| . .|
lnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnlee

NDQEVCYQYWSN---GKLGEYNISLLNEEiHNAGYIERKIEVTNDNKAgDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDT
 |.  . .|| .    . || ..|||..| . | .| ||..|.. ... ....|.| . |.| . |  .| ...| ..... ..|.. ||....|.||. 
ldktkyhkywPdegketygeitvsllske.efadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaG

VGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
||||  |.|  . ... |.| |.|||||.|  |...||.|||
vgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 869-1096 1.1e-54 180.2 In-house 29-278 (301) alignment 
Range on Protein: 869-1096
Range on HMM: 29-278/301.0
QRPDEVTHNiaSQNNDRNRLNQFLPPDNYRVPLKG------EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEV
... .|...  ..|.  || ..  . |. |. ||        . .|||| .|.||.|||.||.|..|| .| ..||..| .  ...|||.....|. .. 
dksctvgls..eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtksk

CYQYWSNGKLGEY-----NISLLNEE----------------IHNAGYIERKIEVTNDNkagDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK
|.|||.|..  ..     .. | ||                   | ||||||..|..|.   . ..| |.|.|.|   | . .|.|.| ||...  .|.|
ceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqk

RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.|
igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtT
0039614 (Phosphotyrosine protein) phosphatases II 869-1096 8.8e-53 175.0 In-house 43-274 (297) alignment 
Range on Protein: 869-1096
Range on HMM: 43-274/297.0
QRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKG-----EHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQeV
. ... ..    .| |.||   .|| |. || ||.     .. ||||| ...||.  ...||..  |. .|  .||.|. . .||.||||....|...  
slkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.k

CYQYWSNG--KLGEYNISLLNEEIhNAGYIERKIEVTNdnkAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSA
|.|||..   . |.. . ||..|  ..||. |..||||    |   .|...| |.|   |   .....| ..|.. . ...  ... ..||||. |||..
caqywpeeggtygdftvtllkveh.ldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|.|| . .. ...|| .||....|  | |.||.|||
tfiaaylmleqlekeggvdvleavkelreqRpgavqt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 873-1096 3.3e-52 172.5 In-house 37-265 (318) alignment 
Range on Protein: 873-1096
Range on HMM: 37-265/318.0
EVTHNIASQNNDRNRLNQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWS
  .. . . |. .|| .  |. |. || |.     |  ||||| .|.||..|||.| | .|. .| ..||.|. ..| . |||| ||.|. .. . .|| 
tslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP

NGKLGEYNI--SLLNEEIHNAGYIERKIEVTNdNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAAT
. .  .|.     |.||.. . |. |...||. ..  ...||.||..|.|  .|  ... ..| .. .  ..|.| |.. ||||||  |||  .|.|  .
skgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdi

TINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 ... | |...||||. |  | |..  |||
llerikaealvDvfqtvkqlreqrnlmvqt
0043336 (Phosphotyrosine protein) phosphatases II 869-1096 9.7e-52 171.5 In-house 32-262 (278) alignment 
Range on Protein: 869-1096
Range on HMM: 32-262/278.0
QRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCY
. .|. .. .  .| |.||   .|| |. || |. .      ||||| ...||. ...||..  |. .|  .||.|. . .|| ||||... |.... |.
fkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkca

QYWSnG---KLGEYNISLLNEEIhNAGYIERKIEVTNdNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMF
|||. |   . |.. . ||.||  ...|. |..|||| .. | ...| .|. ..|   |  ......|  .... . ..   |. ..||||. |||...|
qYwp.ggsltygdftvtllkeeh.lddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtf

CAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|. . ..  ..|| .|.....|  | |.||.|||
ialyllleqlekeggvdleeavkelreqRpgavqt
0045098 (Phosphotyrosine protein) phosphatases II 869-1096 1.5e-51 170.8 In-house 20-257 (278) alignment 
Range on Protein: 869-1096
Range on HMM: 20-257/278.0
QRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPlkgehpDYINAVFINGYkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWS
  |.|.|...   | |.||  ..|| |. ||       ||||| .|.||  .|.||..  |. .|. .||.|. . ..|.||||... |...| |.||| 
gipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

NGK---LGEYNISLLNEEIHnAGYIERKIEVTND---NKAGDKQQVKQYQITNWDSTGKMTNP--QTILLVIEEMYRTQR------------KRGNTSIV
.|.    |.. . ||.||..   |. |...|||     . . .  |.......|.  |  ..|  . .| ..|.. . ..              ... ..
eggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQT
||||  |||.....|| . .  .  ||..|.....|  | |.|| .||.
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqn
subfamily_PTPRG_pd Subfamily PTPRG 695-866 5.2e-51 168.5 In-house 1-175 (563) alignment 
Range on Protein: 695-866
Range on HMM: 1-175/563.0
IPVDKFGEFVAKGHAKGNEGFRNQFGMLDS--GESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDCTnEYINACYIKDYSNQYQYIATQGP
.||..| . ||. ||.|. || ..|  | |   ..| ...    |.||  ||  ||| ||  |..|.|..|.|.   .|||| ||. |  . ..||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

VSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVL--EQ
. .|. ||||.||....||||||||. |.|. ||..|||  ....|| ..||| .|.||. ||||.. .| |  ..
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 880-1096 8.3e-51 167.6 In-house 7-227 (250) alignment 
Range on Protein: 880-1096
Range on HMM: 7-227/250.0
SQNNDRNRLNQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEvCYQYWS---NGKL
 ||...||  .... |. || |. |.     |||||.|..||.|.||||.. .|. .|  .||.|. ......|||| . .|.... . |||      | 
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky

GEYNISLLNEEIHnAGYIERKIEVTNDNKAgDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
|.  .|||..|.. | |. ||. ... .|| |...|.|.. ..|   |   . ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |
Gdvtvsllskeef.adytkrklklskakka.derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

TEGVIDVFQVLKSQRIQKPGSVQT
.| |.|||.|.|  |...|..|..
kekvvdvfkvikvlrkdrphaves
0051299 (Phosphotyrosine protein) phosphatases II 694-864 3.1e-50 166.6 In-house 4-172 (288) alignment 
Range on Protein: 694-864
Range on HMM: 4-172/288.0
MIPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGhkDCTNEYINACYIKDYSNQYQYIATQGPV
 |.|... ..| | .|.|. |....| .| |   |.|....| | |.  ||. .|. ||..|. |....|  . .. |||| ||. | .. ..|||||| 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPl

SNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVL
.||. ||||..|.... .|||.|...| |. || ||||..... ||...||| .|.|| |||||...|. |
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 695-869 6.5e-50 165.0 In-house 2-174 (318) alignment 
Range on Protein: 695-869
Range on HMM: 2-174/318.0
IPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYIKDYSNQYQYIATQGPVS
|.|... . |.. ...|.  . ... .|.  |.  | .  |.| ||  ||.|||. ||. |. |....|..  . .|||| ||  | .. .|||.|.|..
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegee..gsDyinanyidGyrrkkayiaaqaPlp

NTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQVTQ
.|. ||||..|.  ||.|||.|.. |.||.|...|||..... ||   |.|..|  |.||..|...|.  |.  .
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeees
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 710-882 2.7e-49 162.5 In-house 12-185 (301) alignment 
Range on Protein: 710-882
Range on HMM: 12-185/301.0
KGNEGFRNQFGMLDSGEsDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERS
| ...| .|.  |..|| |.. ||||. .|| |||| ||.|||||||.|.|..  . |..||||| ||..||.. ..||.|||. .||||||||||||. 
khsnkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

AIIVMITNIIEEGKMKCQQYWPDSD--TKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQVTQRPDEVTHNIASQN
. |||.||  |. | ||.||||.|.  ....|||.|||..|||. |...|.. ||. .   .   | . .. |..
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 871-1096 2.9e-49 162.9 In-house 37-268 (319) alignment 
Range on Protein: 871-1096
Range on HMM: 37-268/319.0
PDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQY
.|....    .|...|| .. |. |. || |.     |  ||||| ||.||.|...|| . .|. ||  .||.|. ....  .|||.. .|. .  . .|
ndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkky

WSNGKLGEYNISLL--NEEIHNAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAA
|.. .  ||   ..  .|| . ..|| ||... . .   .  .||..| |.|   .  .. ...| ..... ....|  .  ||||||. |||   |.. 
wpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivl

ATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
  .... | |||.|||.. .  |.|..  ||.
damlervkeegvlDvfstvsrlRtqRnimvqr
0042113 (Phosphotyrosine protein) phosphatases II 879-1096 2.9e-49 163.1 In-house 6-228 (245) alignment 
Range on Protein: 879-1096
Range on HMM: 6-228/245.0
ASQNNDRNRLNQFLPPDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG---K
   | |.||  ..|| |. || |. .      ||||| ...||. .. ||..  |. .|  .||.|. . ..|.||||..| |.... |.|||..|   .
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslt

LGEYNISLLNEEIhNAGYIERKIEVTNdNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKC
 |.. . ||.||. ...|. |..|||| .. . ...| .|. ..|.  |  ......| ..|.. . ... .|. ..||||. |||...|.|| . ..  
ygdftvtllseeh.lddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

KTEGVIDVFQVLKSQRIQKPGSVQT
..|. .......|  | |.||.|||
ekelgvsleeavkelrsqRpgavqt
0040439 (Phosphotyrosine protein) phosphatases II 874-1096 4.4e-49 162.7 In-house 3-231 (249) alignment 
Range on Protein: 874-1096
Range on HMM: 3-231/249.0
VTHNIASQNNDRNRLNQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSN
... .   | |.||   .||.|. || |.     .. ||||| .|.||. |..||..  |. .|  .||.|. . ..|.||||... |...| |.|||..
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

G---KLGEYNISLLNEEIhNAGYIERKIEVTNDnKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAA
|   . |.. . ||..|. ...|. |..|.||  . |.. .|...|.|.|  .|   .....|  ||..   ...   .. ..||||. |||...|.|| 
ggsleygdftvtllsvev.kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
. ..  ..|. .|.....|  | |.||.||.
lmleqlekelgvdleeavkllrsqRpgavqn
subfamily_PTPRA_pd Subfamily PTPRA 880-1096 4.7e-48 158.8 In-house 56-280 (330) alignment 
Range on Protein: 880-1096
Range on HMM: 56-280/330.0
SQNNDRNRLNQFLPPDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSN-GKL--
 .|...||. . || |  || |    | |. ||||| ||.|||||. || |  |  .|  .||.|| ... ..|||| . .| ..| |.||| . | .  
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvty

GEYNISLLNEEiHNAGYIERKIEVTNDNK---AGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTIN
|. .... .|.     |  ||. |.. ..     ....|.|.  | |   |  ..|. .| ..... ..... .. .||||||  |||.  |..  . ..
Gnirvevedet.vlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavle

KCKTEGVIDVFQVLKSQRIQKPGSVQT
. |.|...|||...|. | |.|  |||
rvkaerkvdvfefvkrlrlqrpqmvqt
subfamily_PTPRB_pd Subfamily PTPRB 694-865 5.5e-48 158.5 In-house 6-176 (293) alignment 
Range on Protein: 694-865
Range on HMM: 6-176/293.0
MIPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYIKDYSNQYQYIATQGPV
 | ..|| |.|.| .|. . .| ... .| . ..|..|..  .. |.  ||. ||. || .|. | ......  ...|||| ||..|. . ..||||||.
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdes..gsDYinanyipgynsprefiatqGPl

SNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDS-DTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLE
 .|. ||||..|...| ||||.|...|.||.||..|||.  ..  ||  .|||  |..|.|...|.....  .
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekek
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 702-865 1.9e-47 156.7 In-house 10-170 (288) alignment 
Range on Protein: 702-865
Range on HMM: 10-170/288.0
EFVAKGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPmsGHKDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFW
. ||| .|....|| ...  | . |....||.|  . |.  ||. ||. || .|. |.   ...  ...|||| ||... .. .|||||||. .|. |||
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkk..leeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDT-KDYGPFSVTLSDEQVLTDYTVRKMHVKvlE
.|......  |||.|...|.|| ||..||||.|. | || . ||| ... |.|...||. ..   
elvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..k
subfamily_Ptp69D_pd Subfamily Ptp69D 879-1095 1.9e-47 156.9 In-house 45-270 (307) alignment 
Range on Protein: 879-1095
Range on HMM: 45-270/307.0
ASQNNDRNRLNQFLPPDNYRVPLK----GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWS---NGK
   |. .|| ..  . |..|| ||     |. ||||| ||.|||||| ||.|  |. .|. .||.|| . .|| |||| ...| ... | .||.   . .
kkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevq

LGEYNISLLNEEIHNaGYIERKIEVTNDNKAG----DKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATT
 |. .. | .|| |.  ||.|...|.. .. .    |...| ||. |.|. .     ....| .||...  ...  .. ||||||  ||||..| | .  
ygdilvklvseekhs.dyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsl

INKCKTEGVIDVFQVLKSQRIQKPGSVQ
....|.|  .|.|.. |  | |..  ||
lqqlkaedkvdifetvkdLrsqRnllvq
0050432 (Phosphotyrosine protein) phosphatases II 684-863 2.2e-47 157.3 In-house 15-190 (308) alignment 
Range on Protein: 684-863
Range on HMM: 15-190/308.0
HGDSSSAKIGMIPVDKFGEFVAKghAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLrpmsghkDCTNEYINACYIKDY--S
...| ...   ..|... ... |  |... ... .|  | |   ... .|.| | || .||. .|. || .|. |       | .. |||| |.. |   
rdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssk

NQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDS---DTKDYGPFSVTLSDEQVLTDYTVRKMHVKV
.. ..|||||| .||. ||||..|.... .|||.|...| |. || ||||..   ... ||.|.||| .|.|| |||||..... 
lprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltn
subfamily_PTPRA_pd Subfamily PTPRA 688-870 5.3e-47 155.3 In-house 7-187 (330) alignment 
Range on Protein: 688-870
Range on HMM: 7-187/330.0
SSAKIGMIPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYIKDYSNQYQYI
.. |   .||.|. | . .  |  |. ||..|  | .|. . |. .     ||  ||. ||. || .|. | ...|...   .|||| .|. | .. ..|
gnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvee..sdyinasfidGykekdkfi

ATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQVTQR
|.||| ..|. ||||.||. .|| |||.|.. |  . ||.|||||  .  ||   |.. ||.|| ||||||. |. | . |..
aaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatre
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 695-863 5.6e-47 155.3 In-house 4-170 (305) alignment 
Range on Protein: 695-863
Range on HMM: 4-170/305.0
IPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGesDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYIKDYSNQYQYIATQGPVS
| .|.. ... . ... ..|. .|. .| .   .... || .  ||  ||...|...||.|| |.. . ..   ..||||.|.. |... .||..|||. 
ialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

NTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTK--DYGPFSVTLSDEQVLTDYTVRKMHVKV
||..||||||..|.   |||.|...|.|| ||.||||.| |.  ..|.|||.|..|.  .||. ||... .
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisi
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 695-864 6e-45 148.7 In-house 5-171 (319) alignment 
Range on Protein: 695-864
Range on HMM: 5-171/319.0
IPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGESDhTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDCtnEYINACYIKDYSNQYQYIATQGPVS
|.|... | . . ...|. .....| .|. ...| |..   .. ||  ||. ||. ||  |..| .. | ..   .|||| .|  | .. ..||||.|..
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegs..dyinasfidgyqerekfiatqaPle

NTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVL
||. ||||..|.|.| |.||.|.. |..|.|...|||. . ..|| . ||| .|. | || .||.... .
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkk
0040438 (Phosphotyrosine protein) phosphatases II 699-863 7e-45 149.1 In-house 4-165 (317) alignment 
Range on Protein: 699-863
Range on HMM: 4-165/317.0
KFGEFVAKGHAKGNEGFRNQFGMLDSGESDhTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYIKDYSNQYQYIATQGPVSNTLV
.. ... . ..... .....| .|.|   | | .|.. | || .||. .|. ||..|. | |..|. |  . |||| |.. .. . ..|||||| .||. 
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdld..sdYInAsyvdgpnlkrkfIatqgPlpntve

DFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKV
||||..|.... .|||.|.  | |. ||.||||. .|. ||.|.||| .|..| ..|.|...|. 
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtleved
0037934 (Phosphotyrosine protein) phosphatases II 879-1096 1.8e-44 147.5 In-house 7-227 (243) alignment 
Range on Protein: 879-1096
Range on HMM: 7-227/243.0
ASQNNDRNRLNQFLPPDNYRVPLKGehPDYINAVFINGYKeKkaFIIAESPMFNTARN----FWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGKLGE
  .| ..||   .|| |. || |.|   ||||| .|.... .  .|.   |. .|  .    ||.|. . ..|.||||... |...| |.|||....  .
lpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtyg

YNISLLNEEIHNAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCAAATT
  .  | .| | ..|. |.....| .  . ...| .|. ..|   |  ..|. .|  ..|..  ...        ..  ..||||  |||.....|| . 
dftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylm

INKCkteGvIDVFQVLKSQRIQKPG-SVQT
. ..   | .|.....|  | |.|| .|||
llll...g.vdleeavkllreqRpgkavqt
subfamily_PTPN12_pd Subfamily PTPN12 877-1096 2.7e-44 146.2 In-house 35-262 (290) alignment 
Range on Protein: 877-1096
Range on HMM: 35-262/290.0
NIASQNNDRNRLNQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG--
  ...|  .||    || |. || |.     |. ||||| ||.| ..|...| | .|. .|  .||.||.. ||. .||.|.| |...  | .||..   
gekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

---KLGEYNISLLNEEIHNAGYIERKIEVTNDnkaGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATT
   . ||....| .|.  . ... | ..|...   .....|.|.. |.|   |  ......| .||.. ..|. . .. .|||||  |||    .|   .
eelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyv

INKCKTEGV---IDVFQVLKSQRIQKPGSVQT
 .  |.| .   .|||... . | |..  |||
rellkaekipeeldvfdlvlelrkqraalvqt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 700-867 4.4e-44 145.9 In-house 14-182 (298) alignment 
Range on Protein: 700-867
Range on HMM: 14-182/298.0
FGEFVAKGHAKGNEGFRNQFGMLDSGES---DHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDCtnEYINACYIKDYSNQYQYIATQGPVSNT
. ...|. ..|.  |. ..|  |.|..|   ... .|. .|.||  ||.|.|. .|  |. |. ... ...  .|||| ... |...  .||||.|. .|
lqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadees..dYiNAsflhaykgrnafiatqaPltet

LVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQV
..||||....| .. |||.||. | .|.|...||||. .. || ..|.|  ... .|..|||..|.  .. 
vedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 874-1096 5.8e-44 145.7 In-house 53-276 (319) alignment 
Range on Protein: 874-1096
Range on HMM: 53-276/319.0
VTHNIASQNNDRNRLNQFLPPDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCqenendQEVCYQYWSN
 |.    || |.||. . |. |. .| |.   | |  ||||| |..||. |. .| |  |. ||  .||.|| . |...||.|       .. | ||| .
qtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywpl

G---KLGEYNISLLNEEiHNAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAA
    | .......   |   | |. |.||...| |  |.....|. .  |   |.   |  .. ...   . |........||||||  |||. .. .  
kivikeerfkvkvdsve.etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
. ... | |  .||.....  | |..  || 
vlldrmkeekqvdvynfvrdlrqqrntlvqd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 874-1096 8.2e-44 145.2 In-house 17-240 (284) alignment 
Range on Protein: 874-1096
Range on HMM: 17-240/284.0
VTHNIASQNNDRNRLNQFLPPDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCqenendQEVCYQYWSN
 |.    || |.||. . |. |. .| |.   | |  ||||| ||.||. |. .| .  |. ||  .||.|| . |...||.|       .. | ||| .
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

G---KLGEYNISLLNEEiHNAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAA
    | .......   |   . |. |.||...| |  |.....|. .  |   |.   |  .. ...   . |........||||||  |||. .. .  
kivikeerfkvkvdsve.eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
. ... | |  .||.....  | |..  || 
vlldrmkeekqvdvynfvrdlrqqrntlvqd
0036941 (Phosphotyrosine protein) phosphatases II 708-864 1e-43 145.2 In-house 8-162 (297) alignment 
Range on Protein: 708-864
Range on HMM: 8-162/297.0
HAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLrpmsghKDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQE
..... ... .|  |..   . . .|.| | |. .||. .|. ||..|. |      .|  . ||||.|.. |. ....|||||| .||. ||||..|..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

RSAIIVMITNIIEEGKMKCQQYWPDS--DTKDYGPFSVTLSDEQV--LTDYTVRKMHVKVL
.. .|||.|. .| |. ||.||||.   ... ||.|.||| ...|  |.|||.|...|. .
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt
subfamily_Ptp69D_pd Subfamily Ptp69D 694-866 1.2e-43 144.4 In-house 3-173 (307) alignment 
Range on Protein: 694-866
Range on HMM: 3-173/307.0
MIPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDCtnEYINACYIKDYSNQYQYIATQGPV
 |..|.  | . . . . ..|. . . .| . |.|.. .|.    |.| ||. .|. .|..|. |... |..|   .|||| .|| | .. ..|| |.||
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkeds..dYinasfikgykekkkfiaaqdPv

SNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQ
 .|. ||||.|..  . .|||..|. |  . ||..|||. |.. ||   |.| .|.  .||. |...|   ..
eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkke
0047943 (Phosphotyrosine protein) phosphatases II 708-864 1.2e-43 144.9 In-house 7-160 (273) alignment 
Range on Protein: 708-864
Range on HMM: 7-160/273.0
HAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLrpmsghKDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQE
...|. ... .| .| |   ..| .|.| | || .||. .|. ||..|. |      .| .. |||| |.. |  . ..|||||| .||. ||||..|..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

RSAIIVMITNIIEEGKMKCQQYWPDSD---TKDYGPFSVTLSDEQVLTDYTVRKMHVKVL
.. .|||.|...| |. || ||||..    .. ||.|.||| .|..  |||||.. .. |
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnl
0046845 (Phosphotyrosine protein) phosphatases II 715-865 3.1e-43 143.6 In-house 2-159 (284) alignment 
Range on Protein: 715-865
Range on HMM: 2-159/284.0
FRNQFGMLDSGESDH--TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHkDCTNEYINACYIKDY-----SNQYQYIATQGPVSNTLVDFWRLIWQE
.. .| .| |   ..  ...|.| | |. .||. .|..||..|. |....|. . ...|||| |.. |      .. ..||||||..||. ||||..|..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RSAIIVMITNIIEEGKMKCQQYWPDSD-TKDYGPFSVTLSDEQVLTDYTVRKMHVKVLE
.. .|||.|...| |. || ||||... .. ||.|.||| .|.|  |||||.. .. |.
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlg
subfamily_PTPRK_pd Subfamily PTPRK 880-1096 3.3e-43 142.7 In-house 41-262 (314) alignment 
Range on Protein: 880-1096
Range on HMM: 41-262/314.0
SQNNDRNRLNQFLPPDNYRVPL---KGE-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG--KLG
 .|...|| .. |..|. || |   .|. . ||||| .|..||  .|||..  |. .| ..||... | | ..|||| .  |. .  |..|| .   . |
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevyg

EYNISLLNEEIhNAGYIERKIEVTN-DNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCK
. .. |.. |. .| .. |   |..   .  ....|.|.| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||. .|.| .. ..  .
dikvelvetel.laelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmie

TEGVIDVFQVLKSQRIQKPGSVQT
.|||.|||.. |. | .|.  |.|
regvvdvfnavktlrsrkvnmvet
subfamily_PTPN6_pd Subfamily PTPN6 706-866 1.4e-42 140.7 In-house 19-181 (306) alignment 
Range on Protein: 706-866
Range on HMM: 19-181/306.0
KGHAKGNEGFRNQFGMLDSGESDHTV--TVGLTPSNKLLNRFANIVVYDDNRITLRpmsGHKDCTNEYINACYIKD--YSNQYQYIATQGPVSNTLVDFW
... ....|| ..|  |.  |. ...  . |  |.||  ||. ||. .|..|..|.    ..   ..|||| |||.   ... .|||||| ...|. |||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

RLIWQERSAIIVMITNIIEEGKMKCQQYWPDSD-TKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQ
|..||| | .|||.|. .| || || .||||.  ...||  |||  .|. |.||..|...|.  ..
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkk
subfamily_PTPRG_pd Subfamily PTPRG 866-1096 5.4e-42 138.7 In-house 31-272 (563) alignment 
Range on Protein: 866-1096
Range on HMM: 31-272/563.0
QVTQRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLK---GEH--PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQ
.....  ...|  . .|  .||  . .. |. || |.   |..   ||||| .|.||. .||||..  |. .|.  ||.|| ..||. |||. . .|. .
etiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergr

EVCYQYWSNGK---LGEYNISLLNEEIHnAGYIERKIEVTN-DNKAG----DKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKrGNTSIVVHCS
. | .|| . .   .|. .. | .||.. | | .|.. . |   |..    ....|.||. |.|  .|  . .   |  ..   .....     ||||||
rkcdvYWPkdesetygalqvtlieeevl.alytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka.eaGPivvHcs

DTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
  |||. ....  | ... ..| ...||..||  | |..  |||
aGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt
0043336 (Phosphotyrosine protein) phosphatases II 695-863 1.1e-41 138.6 In-house 2-166 (278) alignment 
Range on Protein: 695-863
Range on HMM: 2-166/278.0
IPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGESdHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYIKDYSNQYQYIATQGPVS
|.| .. ..... ..... .....|  |.|     | ...| | || .||. .|. || .|. | ...|. |  . |||| |.. |. . ..|||||| .
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlp

NTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPdSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKV
.|. ||||..|.... .|||.|.  | |. ||.|||| .... ||.|.||| .|..| |||||...|. 
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn
0045450 (Phosphotyrosine protein) phosphatases II 694-864 1.3e-41 138.8 In-house 8-188 (307) alignment 
Range on Protein: 694-864
Range on HMM: 8-188/307.0
MIPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGES--DHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHkDCTNEYINACYI--------KDYSNQ
.|.. |.  .|.. ......|.. .| .| | .    .. ...| | || .||. .|. ||..|. | ...|. . .. |||| |.        . | ..
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlk

YQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSD-TKDYGPFSVTLSDEQVLTDYTVRKMHVKVL
 ..|||||| ..|. ||||..|.... .|||.|. .| |. || |||||.. .. ||.| ||| .|..| .||||...|. |
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 869-1096 2.1e-41 136.9 In-house 34-264 (288) alignment 
Range on Protein: 869-1096
Range on HMM: 34-264/288.0
QRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCY
.. ..||    ..|...|| .. || |  || ||.    .  ||||| .|.|.|.||..| . .|. .|  .||... ..... |||| .  |.... | 
ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCe

QYWSNGKL----GEYNISLLNEEiHNAGYIERKIEVTndnKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVGRSAM
.|| ...     |. .. |.... .   ...||...    | ... ...||| . |  .|   . . .| ... .  .. .     |.||||. |||.  
eYWPdadkpknyGsvtvtlvesk.eledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgt

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
| |. . |.. ..| .|||. ...  | |..  |||
FialdalidaveeedyiDvagtvaklRkqRallvqt
0039614 (Phosphotyrosine protein) phosphatases II 691-868 2.8e-41 137.3 In-house 10-179 (297) alignment 
Range on Protein: 691-868
Range on HMM: 10-179/297.0
KIGMIPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGESDhtVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHkDCTNEYINACYIKDYSN-QYQYIAT
.  .||.. .  .. . .|... .....| .| |   |   ...| | || .||. .|. ||..|. | |. |. |  . |||| |.. |.  . ..|||
esipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIat

QGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKmKCQQYWPDSDTkDYGPFSVTLSDEQVLTDYTVRKMHVKVleqvT
||| ..|. ||||..|.... .|||.|. .| |. ||.||||.. .  ||.|.||| ....| .||||...|.     .
qgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....n
DSPc_SM00195 715-874 3e-41 136.9 In-house 2-160 (263) alignment 
Range on Protein: 715-874
Range on HMM: 2-160/263.0
FRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHkdCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVM
....|  |.. .|....| .  ..||  ||. ||..||..|. | .  ..   ...|||| ||| .... .||||||| ..|. ||||..|.|.. ||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

ITNIIEEGKMKCQQYWPDS--DTKDYGPFSVTLSDEQVLT-DYTVRKMHVKVLEQvtQRPDEV
.|.  |.|| ||..|||..  .....| .||.| ...    ....|.....  ..  . . .|
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkv
PTPc_SM00194 715-874 3e-41 136.9 In-house 2-160 (263) alignment 
Range on Protein: 715-874
Range on HMM: 2-160/263.0
FRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHkdCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVM
....|  |.. .|....| .  ..||  ||. ||..||..|. | .  ..   ...|||| ||| .... .||||||| ..|. ||||..|.|.. ||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

ITNIIEEGKMKCQQYWPDS--DTKDYGPFSVTLSDEQVLT-DYTVRKMHVKVLEQvtQRPDEV
.|.  |.|| ||..|||..  .....| .||.| ...    ....|.....  ..  . . .|
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 879-1096 4.2e-41 135.8 In-house 41-262 (315) alignment 
Range on Protein: 879-1096
Range on HMM: 41-262/315.0
ASQNNDRNRLNQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSN-----
 ..|  .|| .  || |. || |    .  . ||||| .|..... ||.| .  |   .  .||.|. . .||.|||. . .|.|.  | ||| .     
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

GKLGEYNISLLNEEIhNAGYIERKIeVTNdnKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTIN
 ..|.....||. |  ... . ||. ||   |. ....| |.| |.|   |   .  ..| .| |.    ... . |..||||  |||. .....   ..
vefGsikvellslea.dtdgvarkl.vtr..kseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevva

KCKTEGVIDVFQVLKSQRIQKPGSVQT
. | . ..|||...|  | ..|  |||
qikrtrsvdvfnfvknlrakrpylvqt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 877-1096 5.2e-41 135.7 In-house 43-269 (297) alignment 
Range on Protein: 877-1096
Range on HMM: 43-269/297.0
NIASQ---NNDRNRLNQFLPPDNYRVPLKG--EH--PDYINAVFINGYKEkkAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQeVCYQYWSN
.  ..   | ...| .  || |  || |.   ..   ||.|| |..|.|.   .|  . || .|  .||.|. | .|..|||| ..||.|.  | .|||.
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsd

GKLGEY-NISLLNEEIH-NAGYIERKIEVTNdNKAGDKQQVKQYQITNWDSTGKMT--NPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAA
    .. ..|.. . ..   |.|.|..|||. .||  .. ||||| ..| .       . ...| .|.|.  .  .. .. ..|||.  ||| .....  
kgvttfGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltid

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
  . . | |  .|.|...|  | ..|  |||
svvaeakrekevdifglvkklrqerpylvqt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 707-863 5.3e-41 135.6 In-house 9-164 (281) alignment 
Range on Protein: 707-863
Range on HMM: 9-164/281.0
GHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQ
 ... |.|| ...  | . . |.| |   .. |.| ||. ||| ||  |... | .  .. ...|||| ... |... .|||||||| ..||.||...|.
lsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpne..enkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvwe

ERSAIIVMITNIIEEGKMKCQQYWPDSD-TKDYGPFSVTLSDEQVLTDYTVRKMHVKV
..  .|||.|. ||.||.|| .|||| . .  || . |.   |.  . |  ||.... 
qkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkler
subfamily_PTPRB_pd Subfamily PTPRB 874-1096 8.9e-41 134.8 In-house 43-270 (293) alignment 
Range on Protein: 874-1096
Range on HMM: 43-270/293.0
VTHNIASQNNDRNRLNQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSN
|. . ...|...|| .. || |. || |    . .. ||||| .|.||. .. || .  |. .|  .||.|. ......|||| |  |. .. | .|| .
vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa

G----KLGEYNISLLNEEiHNAGYIERKIEVTNdnkAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQ-RKRGNTSIVVHCSDTVGRSAMFCAA
       |. ...|..|| .   .. |......   . ....|.||. | |   |   ...|.|  .... ... ..  .. ||||||  |||.  | | 
deepvlyGdikvtlvaee.eledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfial

ATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 . ... ..| ..|.| .. . | ..   |||
drllqaieeedyvdifgivaelReeRnllvqt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 881-1096 2.8e-40 132.9 In-house 42-261 (515) alignment 
Range on Protein: 881-1096
Range on HMM: 42-261/515.0
QNNDRNRLNQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSN-----GK
 |  .|| .  || |. || |       | ||.|| .|....  ||.| .  |   .  .||... . |||.|.|. . .|.|.  | .|| .      |
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

LGEYNISLLNEEIhNAGYIERKIEVTNDNKagdKQQVKQYQITNWDSTGKMTNPQTILLVIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKC
.|.....|.  |   .| | ||..|. ...    . | |.. |.|   |   . ...| .| |. .... . . ....|||  |||  .....   . . 
fGsikvelvslea.ctggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvaha

KTEGVIDVFQVLKSQRIQKPGSVQT
||  ..|||....  | ..|  |||
kttrmvdvfnfvtnirqkrpylvqt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 695-867 4.3e-40 132.6 In-house 6-174 (315) alignment 
Range on Protein: 695-867
Range on HMM: 6-174/315.0
IPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGEsDHTVTVGLTPSNKLLNRFANIVVYDDNRITLrPMSgHKDCTNEYINACYIKDYSNQYQYIATQGPVS
||.|..  .||. .|  ..||....  .  |.  | . |     ||  ||. ||. ||  |. | |.   .|   .|.|| .|. |. . .|||.|||  
ipldqlityvaqkkastkngfkqdyesipggq.lhpldvakkienkqknryiniiaydksrvql.pll.endphsdyvnanfidGynkkrryiaaqgpnv

NTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSdTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQV
... |||||...|  . |||.||..|. | |...||||     ||...||. .|.| |.|||| . | . ...
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgdni
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 879-1097 5.1e-40 132.4 In-house 38-262 (281) alignment 
Range on Protein: 879-1097
Range on HMM: 38-262/281.0
ASQNNDRNRLNQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGK---
| .|  .|| .     |. || .    . .. ||||| |..|||..|..|....|. ..  .||.|. ...|.||||. .| |...  |..|| ...   
adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnsel

-LGEYNISLLNEEiHNAGYIERKIEVtnDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINK
 .|.. .. ..|| ..| |||||...  ... |....|.| . |.|  .|  .... .|   .|......|. ....|.|||  |||.  . |  . ...
kygdvtvkstaee.ekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvka

CKTE-GVIDVFQVLKSQRIQKPGSVQTV
...|   .|| .|... | ..   ||||
veaeleeldvkavvaelrkernlmvqtv
subfamily_PTPN23_pd Subfamily PTPN23 875-1096 9.1e-40 131.3 In-house 36-265 (288) alignment 
Range on Protein: 875-1096
Range on HMM: 36-265/288.0
THNIASQNNDRNRLNQFLPPDNYRVPLKGEHPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSN----
.  ||  . ..|| .  || |. || |.|.. ||||| |...       ||.. .|. .|.  ||.|. .. .  |||| ...| ... . .|| .    
siaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkge

-GKLGEYNISLLNEEiHNAGYIERKIEVTNDnKAGDKQQVKQYQITNWDSTGKMTNPQTILLVI---EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAA
  | |.....| ... .   ..||.....   .|  ...|.  |.|.| . |    |.|.| ..   |..|...... .| .|||||  |||. .|.   
tvkfgdlsvtlksvr.etethvervlkletl.dadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvy

TTINKCK-TEGVIDVFQVLKSQRIQKPGSVQT
. ... .  .|..|. ||..  | |.  .||.
aavrelekgnglldiiqvvsrlreqRrfmvqe
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 710-862 4.2e-39 129.1 In-house 6-153 (283) alignment 
Range on Protein: 710-862
Range on HMM: 6-153/283.0
KGNEGFRNQFGMLDSGESDHTVTVglTPSNKLLNRFANIVVYDDNRITLRPMSGhkdctnEYINACYIK---DYSNQYQYIATQGPVSNTLVDFWRLIWQ
..|. ||...  |   . | ....  .  ||  ||. .||..| .|. |.. |       .||||..|    .| .. .||..|.|. .| ||||.....
nnnklfrevlkrlsvpdldadias..adenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfd

ERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVK
|. . |||.|.. |. ..|| ||||   ..|||.| ||| .|     ...... ..
ekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllr
0045098 (Phosphotyrosine protein) phosphatases II 722-864 5.8e-39 129.5 In-house 16-144 (278) alignment 
Range on Protein: 722-864
Range on HMM: 16-144/278.0
LDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITlrpmsghkdctnEYINACYIKDYsnQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEE
| .  .  ..|..| ..|. .||. .|. || .|.             .|||| ||. |  . ..||||||  .|. ||||..|.... .|||.|. .| 
llllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

GKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVL
|. || ||||..... ||.|.||| .|.|| |||.|...|  |
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnl
subfamily_CG7180_pd Subfamily CG7180 873-1095 8.9e-39 127.9 In-house 33-274 (296) alignment 
Range on Protein: 873-1095
Range on HMM: 33-274/296.0
EVTHNIASQNNDRNRLNQFLPPDNYRVPLK---GE-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQeVCYQYWS
.  ... ..| ..||  . .|.|. || |.   || . ||||||.....  ||..|. | |. .|  .||... |... |.|.|... .  .  . .|| 
dCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

NG---KLGEYNISLLNEEIHNAGY-----IERKIEVT---NDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRG-----NTSIVVHCS
|    . ||  . ...|.   .       . .||  .   . .   ..  ||..|.| |..  |.    . |. . .. |. |..      .  .||..|
nkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvss

DTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQ
| ..|| ...|.  .... . |. .|||. .|  |...|. |.
dGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLve
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 733-865 1.1e-38 127.9 In-house 3-132 (250) alignment 
Range on Protein: 733-865
Range on HMM: 3-132/250.0
VGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDCtnEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMkCQQYWPD
|.  |.||  ||.|.|. .|  |. | . .| |..  .|||| ... |...  .||||||...|..||||....| |. |||.||. |..|  ..|||| 
vakkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

SDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLE
  .. ||   |.| .... .|||.||. .   .
ekaekyGdvtvsllskeefadytkrklklskak
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 878-1097 1.8e-38 127.5 In-house 44-274 (325) alignment 
Range on Protein: 878-1097
Range on HMM: 44-274/325.0
IASQNNDRNRLNQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNvTAIVMLCQENENDQEVCYQYWSNG---
   .| ..||..  .. |. || |.      . ||||| ... .|.|. |. | .|. .|  ..|... | . ...|..  | ..... | .|| .    
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgk

--KLGEYNISLLNEEIHnAGYIERKIEVTNdNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVI---EEMYRTQR--KRGNTSIVVHCSDTVGRSAMFCA
  ..|  ...|   |   . |. |...| .  | |. . |||.|.  ||  |    | |.. ..   ...  . .   .. | |.||||. |||. .| .
sktfGglevklrtieei.sdyvhrvldvkq.vkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  . ..|  .|  .|.|...|  | ..|  |.||
lysalakvieesrvdifgfvkklrkdrpsmvetv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 862-1096 3.1e-38 126.3 In-house 13-244 (267) alignment 
Range on Protein: 862-1096
Range on HMM: 13-244/267.0
KVLEQVTQRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQE
. ......    ..  ||..|..||||.. || |. ||.|. .  .|||| ...||| |.|||. . |. ||  .|...| |..|. ||.| .  ...  
elikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnir

VCYQYwSNGKLGEYNISLLNEEIHN--AGYIERKIEVTNDNKagDKQQVKQYQITNWDSTGKmtNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSA
  .     |.  .|.   ..  . .    |    .|.   |.    ..|  |   .|.   .  |   .  ..  . . | . ||  .||.||| |||| 
lfwPP.kmgqakkyqdltvehslekeendyqiitlelkfkne..sahnvtlyyykkwnintn..nkpylkplfgilaknqlengnrPlvvacsdGvGrsG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 |  . . ... ||||| |.|. |.  | |..| |.|
tflvidsqleraktegvsdifdflrkirsqriglvdt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 880-1096 4.4e-38 126.0 In-house 47-264 (315) alignment 
Range on Protein: 880-1096
Range on HMM: 47-264/315.0
SQNNDRNRLNQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGKL--G
..| ..||  . .. |. || |    . .| ||.|| ||.||. |. .| |..|  .. ..||... . ... |||| .  |.... . .|| . |.  |
ienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyG

EYNISLLNEEiHNAGYIERKIEVTNDNKAgdkQQVKQYQITNWDsTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
.. ... .|| .|  |  | . |. ...    ..| |...| |  . ....  . |. .    .  ..   ..||||||. |||.  |..  . ... ..
kitvtrksee.vnteytvrtlsvvfgdni...revvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaea

EGVIDVFQVLKSQRIQKPGSVQT
| .|||.....  | .. . ||.
enaidvynfitgvrqnrikmvqv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 693-865 5.5e-38 125.9 In-house 3-173 (325) alignment 
Range on Protein: 693-865
Range on HMM: 3-173/325.0
GMIPVDKFGEFVAKGHAKGNEGFRNQFGMLDSGESdHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMsgHKDCTNEYINACYIKDYSNQYQYIATQGP
| | | .. |.| | .|. ..|| ..||.| | ..  . .|   | ||  ||| |.| .| .|. |  .  ..|   .|||| |..|. ..  ..|.| |
gsiavvnlvehvekkkaqdqdgfahefgllpsddg.iakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaP

VSNTLVDFWRLI--WQersAIIVMITNIIEEGKMKCQQYWPDS--DTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLE
 ..|. |.|||.  |.   . .|...|....|| .| .|||.   ..| .|.. | |   . ..||  |...||  .
ltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk
subfamily_PTPRK_pd Subfamily PTPRK 714-869 5.6e-38 125.5 In-house 23-170 (314) alignment 
Range on Protein: 714-869
Range on HMM: 23-170/314.0
GFRNQFGMLDSGesdhtVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGhkDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIV
||....  |  |       .     |.  ||. .|. ||  |..| .. |  |  ..|||| .|  | .  ..|.||||. .|. |||||...|..| ||
gfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasiv

MITNIIEEGKMKCQQYWPDSDTKdYGPFSVTLSDEQVLTDYTVRKMHVKVLEQVTQ
|.|...|.|..|| .|||.  .. ||.. |.| . ..|... || . |. |..  .
mltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqe
subfamily_PTPN12_pd Subfamily PTPN12 729-863 1.2e-37 124.4 In-house 30-165 (290) alignment 
Range on Protein: 729-863
Range on HMM: 30-165/290.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQ
.. ..| ...|.  ||. .|. || .|..|. .....   ..|||| .||  ... .|||.|||...|| ||||.||. .  |.||. ...| ||.||..
ysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPDSDTK--DYGPFSVTLSDEQVLT-DYTVRKMHVKV
|||..  .   .|.|.|||..|. .. |...| ..|..
YWpeegeeelefgefevtleeekavdddflirtLkvea
subfamily_PTPN9_pd Subfamily PTPN9 702-870 1.3e-37 124.4 In-house 5-173 (297) alignment 
Range on Protein: 702-870
Range on HMM: 5-173/297.0
EFVAKGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFW
|.||  ..||..| ....  . . .   |...  ...|   ||..... ||. |..|  .....  . .|||| ..  | ..  .||||||. .|  |||
elvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfW

RLIWQERSAIIVMITNIIEEGKMKCQQYWP--DSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQVTQR
|..|...  .|||.| ..|.|..||.||||  . .....| .||.  . ..  ||.||....|  ..  .|
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesr
Y_phosphatase Protein-tyrosine phosphatase 739-866 1.6e-37 124.5 Pfam-A 1-128 (235) alignment 
Range on Protein: 739-866
Range on HMM: 1-128/235.0
NKLLNRFANIVVYDDNRITLrpmsgH-----KDctneYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWP--
||  ||. .|..||..|. |     .     .|    |||| |.| |... ..||||||...|. ||||..|||.. .|||.|.  |.|. ||.||||  
nkkknRykdilpydktrvkl.....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

DSDTKDYGPFSVTLS-DEQ-VLTDYTVRKMHVKVLEQ
..... || ..|.|  .|.   ..||.||...|  ..
eeesltygdikvelkekekedekeytlrklelkkkke
Y_phosphatase Protein-tyrosine phosphatase 739-866 1.6e-37 124.5 In-house 1-128 (235) alignment 
Range on Protein: 739-866
Range on HMM: 1-128/235.0
NKLLNRFANIVVYDDNRITLrpmsgH-----KDctneYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWP--
||  ||. .|..||..|. |     .     .|    |||| |.| |... ..||||||...|. ||||..|||.. .|||.|.  |.|. ||.||||  
nkkknRykdilpydktrvkl.....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

DSDTKDYGPFSVTLS-DEQ-VLTDYTVRKMHVKVLEQ
..... || ..|.|  .|.   ..||.||...|  ..
eeesltygdikvelkekekedekeytlrklelkkkke
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 880-1096 1e-36 121.5 In-house 26-253 (274) alignment 
Range on Protein: 880-1096
Range on HMM: 26-253/274.0
SQNNDRNRLNQFLPPDNYRVPLKGE-----HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGKL-
. .. .|| .. || .| || |. |       .|||| .| ||.| .||.. .  |. ||  .||.||  ..|. |||| . .|.... | .|. . .  
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

---GEY-NISLLNEE-IHNAGYIERKIEVTNDNKagdKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAA
   ..| .... .|. ... .|  ||. . . ..   ...|| |  |.|  .    ...|.| ...|. ...... .   ..|||||  .||  .| |. 
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 .... . |.|.||...    |... | |||
iavrqlreeivvdvlkivcnlrldrGGmvqt
0040439 (Phosphotyrosine protein) phosphatases II 730-864 5.7e-36 119.8 In-house 2-134 (249) alignment 
Range on Protein: 730-864
Range on HMM: 2-134/249.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGhkDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQY
...|.| | || .||. .|. || .|. | ...|     . |||| ||. |  . ..|||||| ..|. ||||..|.... .|||.|.  | |. ||.||
eysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVL
||..... || |.||| ...|. |||||..... |
wplggsleygdftvtllsvevkddytvrtleltnl
subfamily_PTPN6_pd Subfamily PTPN6 880-1096 8.7e-36 118.4 In-house 52-282 (306) alignment 
Range on Protein: 880-1096
Range on HMM: 52-282/306.0
SQNNDRNRLNQFLPPDNYRVPLK---GEHPDYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSN----G
 .|. .|| .  || |. || ||       ||||| .|..   ...|..| ..  . .|  .||.|. . | . |||. .|.|  .| |..|| .     
penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeeke

KLGEYNISLLNEeIHNAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATT
. |..... ..|  ..| || |.. |.. .|......| ||. ..|   |  ..|...|  .|.. | |..     . .||||||. .||   |    . 
eyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDil

INKCKTEGV---IDVFQVLKSQRIQKPGSVQT
... ...|.   ||. .. || | |. | |||
lkliekkgldadidiqklvksvreqrsglvqt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 738-864 9e-36 118.3 In-house 2-126 (237) alignment 
Range on Protein: 738-864
Range on HMM: 2-126/237.0
SNKLLNRFANIVVYDDNRITLRPMSGHkdctNEYINACYIKDYSN-QYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDT-
 ||. ||..|||.|| .|. |.   .      .||||.|.|..     .|||.|||. ..  |||...|||. ..|||.| .||  ..|| .|||..|  
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

KDYGPFSVTLSDEQVLTDYTVRKMHVKVL
. || ..|.|  .. ..||||| . . . 
aaygvltvslkkkeefsdytvrslllskr
subfamily_PTPN3_pd Subfamily PTPN3 878-1096 1.1e-35 117.9 In-house 37-260 (280) alignment 
Range on Protein: 878-1096
Range on HMM: 37-260/280.0
IASQNNDRNRLNQFLPPDNYRVPLKGEHPDYINAVFIN----GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSN----
  ..| ..||    || |. || || .. ||||| ..|    . .  . .|..  |. .|| .||.|. ..... |||| .  |. .  |.||| .    
rkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetede

GKLGEYNISLLNEeIHNAGYIERKIEVTNDNKaGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN
 ..||... . .|  ..  |. |.. ... ..  ..... | | ..|   |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  |.. 
leygefsvkceke.detksyvlrelvlkdket.keerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletala

KCKTEGVIDVFQVLKSQRIQKPGSVQT
.  ..  . . ....  | |.   |||
lieaaepvypldivrtmrdqramlvqt
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 739-869 1.7e-35 117.3 In-house 8-133 (239) alignment 
Range on Protein: 739-869
Range on HMM: 8-133/239.0
NKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYIKDYSNQ-YQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKd
||  ||.|||| || .|. |  .|  .|  ..|||| |..||      |||||| |. .  ||||..|||| ..|||.| .||  | ||.|||||| .| 
nkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGPFSVTLSDEQVLTDYTVRKMhvkVLEQVTQ
|  . |||   .|..|| .| .   |. || |
ycnlrvtlrktevfadyiirtf...vmsqvgq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 739-869 1.8e-35 117.2 In-house 7-132 (239) alignment 
Range on Protein: 739-869
Range on HMM: 7-132/239.0
NKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYIKDYSNQ-YQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKd
||  ||.|||| || .|. |  .|  .|  ..|||| |..||      |||||| |. .  ||||..|||| ..|||.| .||  | ||.|||||| .| 
nkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGPFSVTLSDEQVLTDYTVRKMhvkVLEQVTQ
|  . |||   .|..|| .| .   |. || |
ycnlrvtlrktevfadyiirtf...vmsqvgq
subfamily_PTPN3_pd Subfamily PTPN3 718-870 3.7e-35 116.2 In-house 20-171 (280) alignment 
Range on Protein: 718-870
Range on HMM: 20-171/280.0
QFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYIKDYSNQ----YQYIATQGPVSNTLVDFWRLIWQERSAIIV
|| .|   . . ....   | |   ||. .|. ||. |..|.      . ...|||| |..  ..      .|||||||...|  |||...|...| .||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MITNIIEEGKMKCQQYWPDS-DTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQVTQR
|.|...|.|..|| ||||.. |. .|| |||... |.  . | .|.. .|  |.  .|
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeer
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 695-862 7.4e-35 115.3 In-house 3-167 (315) alignment 
Range on Protein: 695-862
Range on HMM: 3-167/315.0
IPVDKFGEFVAKGHAkgNEGFRNQFGMLDSGESdHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYIKDYSNQYQYIATQGPVS
||| .|  || | .      | ..|  |   .  .  .|. .. |   ||. ||. .| .|. |  .   ..  ..|||| ||| . ..  |||.|||  
ipvaqfpafvnknrh..talfseefhdlpdPdi.yrqrvaretinfkknryknilPldsarvklevid..dsPdsdyinasyiksvdddkayiasqgPlk

NTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPD--SDTKDYGPFSVTLSDEQVLTDYTVRKMHVK
 .. ||||...||. . |||.|.  |. |.||.|||||  .|. ..| ..|.| . .  || ..||. ..
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtr
0042113 (Phosphotyrosine protein) phosphatases II 733-868 7.8e-35 115.8 In-house 3-136 (245) alignment 
Range on Protein: 733-868
Range on HMM: 3-136/245.0
VGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDCTneYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPD
|.| | || .||. .|. ||..|. | |..|. |..  ||||.|.. |    ..|||||| ..|. ||||..|.... .|||.|.  | |. ||.||||.
vallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

SDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQVT
.... || |.||| .|..| |||||...|. |    
gesltygdftvtllseehlddytvrtlevtnlgdde
subfamily_PTPN9_pd Subfamily PTPN9 879-1096 8.4e-35 115.2 In-house 39-275 (297) alignment 
Range on Protein: 879-1096
Range on HMM: 39-275/297.0
ASQNNDRNRLNQFLPPDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWS-----N
   |  .|| .  |  |. || |.     |. ||||| |..|||.||||| .  |. .| ..||.|. ...|  |||  .  |. .  | |||       
lranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeess

GKLGEYNISLLNEEIHNAgYIERKIEVTNdNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQR---------KRG---NTSIVVHCSDTVGR
 . |....| .. | ... | .|..|..|  | .....|  .|.. |   |   . ...| |.|.. ..|          ..|   .  ||||||  .||
aefgdlsvsnveveeeed.ykvrvleikn.vkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGr

SAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.  |..   .... ...|..||....|  | |.  |.||
tGtfitldiclsrleevgtvdvvetvkllrtqrafsiqt
subfamily_PTPN13_pd Subfamily PTPN13 875-1096 2.9e-34 113.6 In-house 30-254 (273) alignment 
Range on Protein: 875-1096
Range on HMM: 30-254/273.0
THNIASQNNDRNRLNQFLPPDNYRVPLKGEHPdYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG--
.     .|.|.||  . || |. ||.|..| . |||| .|.    |..  .|..  |. .|...||.|. ..... |.|. .| |...  | .|| .   
evgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPeskn

-KLGEYN-ISLLNEEI-HNAGYIERKIEVtNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATT
 ||  .| . . .... .  |.  |...| .|...|. ..| . . ..|   |  .... .| .. |. | |.   .. ||||||  .||| .. .  . 
kklkvsnrlevellkvqkldgfvvralav.kdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvv

INKCKTEGVIDVFQVLKSQRIQKPGSVQT
..  . .  .|| ..... | |. | |||
lglierdkefdvkeivrklreqrqgvvqt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 878-1096 5.4e-34 112.4 In-house 16-249 (270) alignment 
Range on Protein: 878-1096
Range on HMM: 16-249/270.0
IASQNNDRNRLNQFLPPDNYRVPLKGEHPD----YINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG--
 | ...  || .. ||  . || |. .. |    |||| ...|... ||..| | .|. .| ..||.|| ...||||||. . .|. .. | .||..   
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

---KLGEYNISLLNEE-IHNAGYIERKIEVTndnKAGDKQQVKQYQITNWDSTGK------MTNPQTILLVIEEMYRTQRKRGN-TSIVVHCSDTVGRSA
   || . .|. |...  .. ||| ......   . |.....  .. ..|   |        .... .| ..... |....  . . ..||||. |||. 
ekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. |  ....  .... .|| ....  | ...  ||.
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqh
subfamily_PTPN23_pd Subfamily PTPN23 710-869 7e-34 112.0 In-house 12-170 (288) alignment 
Range on Protein: 710-869
Range on HMM: 12-170/288.0
KGNEGFRNQFGMLDSGESDHTV--TVGLTPSNKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYIKDYSNQ-YQYIATQGPVSNTLVDFWRLIWQ
.|. .. ..|  |.. .  ..   .. .   .   ||. .|. || ||..||      . ...||||...|| | .  ..||||.|  .|| |||.....
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

ERSAIIVMITNIIEEGKMKCQQYWPDS--DTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQVTQ
..| .|||...  | || |...||| .  .|. .|..||||.... .  .  |......|.. . 
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadav
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 740-876 1.6e-33 111.0 In-house 29-165 (274) alignment 
Range on Protein: 740-876
Range on HMM: 29-165/274.0
KLLNRFANIVVYDDNRITLRPMSGHKDcTNEYINACYIKDYSNQY-QYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTK--
.  ||. .|.  .  |..|.. |....   .|||| ||| |...   |.|||||..||. ||||.|.||.. .|||.|.. |. . ||..|.||.     
qtknryktilPnensrvllesessede.dssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

--DYGPFSVTLSDEQVLTDYTVRKMHVKVLEQvTQRpdeVTH
   || .... ..     ||.|||. .| ||. ...   |.|
serygdveikvekiverndysvrklvlkyler.ers...vkh
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 881-1097 1.8e-33 110.6 In-house 37-263 (287) alignment 
Range on Protein: 881-1097
Range on HMM: 37-263/287.0
QNNDRNRLNQFLPPDNYRVPL--KGEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG----KLG
 .  .||  . || |. || |  .||.  ||||| .. .|....||| | .|.  | |.||... .......... .| |. .  ||.|| .     ..|
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYNISLLNEEIHNAGYIERKIEVTNdNKAGDKQQVKQYQITNWdsTGKMTNPQ---TILLVIE--EMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATT
 | . ||. .| .  |  | . . .  .. . . |||... .|    |   |     | .|..  .    .|.  .   .|||..  .||| .. |  . 
GysvvlldydikePeygvralrlid.letrearvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

INKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... .  | .|| .|.   | .. . ||.|
vsrledlGrvdvaavvirlreyraalvqav
subfamily_PTPN1_pd Subfamily PTPN1 866-1096 7.6e-33 108.5 In-house 14-256 (290) alignment 
Range on Protein: 866-1096
Range on HMM: 14-256/290.0
QVTQRPDEVTHNI--ASQNNDRNRLNQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVC
....  ......     .|...||     | |  |. |. .. ||||| ...  . |. .|..  |. ||.  ||.|. ...  |.||| .  |..|  |
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

YQYWSNGKL------G--EYNISLLNEEIHNAgYIERKIEVTNdNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQR-KRGNTSIVVHCSDT
.||| .|.          .... |..||...  |. |..|..|  |. . ... ..  | |   |    |.. |  . .. ..   ..     |.|||  
aqywPqgeeekellledtklkvkliseerksy.ytvrllelen.lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQT
.|||  || . | .    | .    .|. .||   | .. | .||
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 732-862 1.4e-32 108.3 In-house 54-176 (319) alignment 
Range on Protein: 732-862
Range on HMM: 54-176/319.0
TVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITniieegKMKCQQYWP
|    . ||  ||. ||. .| |.. |... |      .|||| ... | .. .|||.|||  ||| ||||.||. ... ||..|      | || ||||
tfanldqnkdknriinilafdknvvklerliGee..fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

DSDTKDYGPFSVTLSDEQVLTDYTVRKMHVK
    . .. | | ..  .   .|.||.... 
lkivikeerfkvkvdsveetaeyvvrdiels
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 732-862 2e-32 107.8 In-house 18-140 (284) alignment 
Range on Protein: 732-862
Range on HMM: 18-140/284.0
TVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITniieegKMKCQQYWP
|    . ||  ||. .|. .| |.. |... |      .|||| .|. | .. .|||||||  ||| ||||.||. ... ||..|      | || ||||
tfanldqnkdknrighilafdknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

DSDTKDYGPFSVTLSDEQVLTDYTVRKMHVK
    . .. | | ..  .   .|.||.... 
lkivikeerfkvkvdsveeseeyvvrdiels
0037934 (Phosphotyrosine protein) phosphatases II 732-865 2e-32 108.1 In-house 3-127 (243) alignment 
Range on Protein: 732-865
Range on HMM: 3-127/243.0
TVGLTPSNKLLNRFANIVVYDDNRITLrpmsghKDctNEYINACYIKDYSNqyqYIATQGPVSNTLVD----FWRLIWQERSAIIVMITNIIEEGKMKCQ
...| | |.  ||. .|. ||..|. |      ..  . |||| .|. . .   .|||||| ..|. |    |||..|.... .|||.|. .| |. || 
siallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPdsDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLE
||||  ... ||.|.||| .|..| |||||..... |.
qywp..gevtygdftvtllseehlddytvrtlllenld
subfamily_PTPN14_pd Subfamily PTPN14 727-870 2.8e-31 103.6 In-house 37-183 (300) alignment 
Range on Protein: 727-870
Range on HMM: 37-183/300.0
SDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMsghKDCTNEYINACYIKDY--SNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKM
 | .....  | |.  ||| ... |.|||. | |    |. ...||||  ||    .....||..|||. .|. |||...|..  ..|||.|...|.|| 
edallstaklpenaeknrfkdvlPyednrvelspt...kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgke

KCQQYWPDS----DTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQVTQR
|. .|.|..    .| ..| | ||    .  . .. .....| |    .|
ksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeer
0036282 (Phosphotyrosine protein) phosphatases II 907-1096 1.4e-30 101.6 In-house 3-155 (174) alignment 
Range on Protein: 907-1096
Range on HMM: 3-155/174.0
DYINAVFINGYKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNgklgeynisllneeihnagyierkievtndNKAGDKQ
||||| .....   . .|.   |.      ||.|. . ..|..|||..|.|.. . |..||.                               ..   ..
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredler

QVKQYQITNWDSTGKMTNPQtILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQT
 . ||. ..|.  |  . .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||
lgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 725-861 2.1e-30 100.3 In-house 29-165 (515) alignment 
Range on Protein: 725-861
Range on HMM: 29-165/515.0
GESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKM
|   .  ||     |   ||. ||. || .|. |  .    .  ..|.|| ||. . |.  |||.|||   .. |||||..||. . |.|.|.  |. |.
gpniypqtvaqeeinfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdki

KCQQYWPD--SDTKDYGPFSVTLSDEQVLTDYTVRKMHV
|| .||||  .|.  .| ..| |   .  |. . ||..|
kcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv
subfamily_PTPN13_pd Subfamily PTPN13 728-866 5.9e-30 99.5 In-house 26-162 (273) alignment 
Range on Protein: 728-866
Range on HMM: 26-162/273.0
DHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGhkdctneYINACYIKDY--SNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMK
  |..|| . .||  ||. |.. ||. |..|   .|       |||| .||     ..|.|||.|||. .|  |||...|. .. .|.|.|.  |.||.|
ldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk

CQQYWPDSDTKD---YGPFSVTLSDEQVLTDYTVRKMHVKVLEQ
|..|||.|  |    .. . |.| . | | ...||...|| .| 
chrywPesknkklkvsnrlevellkvqkldgfvvralavkdses
subfamily_PTPRN_pd Subfamily PTPRN 726-869 7.8e-30 98.6 In-house 42-186 (297) alignment 
Range on Protein: 726-869
Range on HMM: 42-186/297.0
ESD-HTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYIKDYS-NQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGK
|.. .| .|. .. |   || .... ||..|..|.  . ..  ...||||  | |    .  |||||||...|. |||...|.. ...||..|.. ||| 
eaepstkevakaeknvkknrskavlpydhsrvklkeeasae..ksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegv

MKCQQYWPDSDTKDYGPFSVTLSDEQVLT-DYTVRKMHVKVLEQVTQ
 .|..||||  .. |. . | |  | . . || || ...| |..   
kqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 695-861 1.1e-29 98.5 In-house 10-168 (297) alignment 
Range on Protein: 695-861
Range on HMM: 10-168/297.0
IPVDKFGEFVAKGHAkgNEGFRNQFGMLdsGES-DHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYIKdySNQYQYIATQGPV
||. .|  .| |..    . |...|  |   |.  .. ||     |   .|..||. || .|..|. .   .|   .|.|| ..|  .|....|.|| | 
iplsdfatlvqknrh..tdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvk..gnkhrlittqmPm

SNTLVDFWRLIWQERSAIIVMITNIIEEGKmKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHV
 .|. |||.....|. ..|||...  |. | ||..||.|. .. .|  ||.|.  .  . .  |...|
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelev
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 742-865 1.9e-29 97.4 In-house 41-163 (287) alignment 
Range on Protein: 742-865
Range on HMM: 41-163/287.0
LNRFANIVVYDDNRITLrpmSGHKDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDT-KDYGP
 ||.|... .||.|. |   | . .   .|||| |.  | .. ..||.|||.. |. ||||.....||| ....|  .||...|| .|||. .     | 
knryadvlPiddtrvll...saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGG

FSVTLSDEQVL-TDYTVRKMHVKVLE
.||.| | ...  .|.|| . .  ||
ysvvlldydikePeygvralrlidle
subfamily_PTPRN_pd Subfamily PTPRN 875-1096 1.9e-29 97.4 In-house 47-277 (297) alignment 
Range on Protein: 875-1096
Range on HMM: 47-277/297.0
THNI--ASQNNDRNRLNQFLPPDNYRVPLKGE----HPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYW
|...  | .| ..|| ...|| |. || || |    . ||||| .|     .  |.| ...|. .|  .||.|. .. |. ||.|.. .|.. . |..||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

SNG---KLGEYNISLLNEEIHNAGYIERKIEVTNDnKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGnTSIVVHCSDTVGRSAMFCAA
 .      . |.. |. | |    |. | . . |  .. . . | |.    | ..|  ......|     . .. | |  ..||||||| .||. .... 
pdeGsevyhiyevhlvsehiwcddylvrsfylknl.qtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGrtGvyili

ATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQT
   .|.  |    ||.   |.  | |.|| |.|
dlvlnrllkGvkeidiaatlehlrdqrpglvkt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 735-862 5.1e-29 96.1 In-house 16-146 (270) alignment 
Range on Protein: 735-862
Range on HMM: 16-146/270.0
LTPSNKLLNRFANIVVYDDNRITLRPMSGhkDCTNEYINACYIKDY-SNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDS
 .  .| |||.|.|.     |..| ...   | . .|||| |.. . ... .|||..||. .|| .|||.||.|..  |||.|.. |.|. ||..||| .
eaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

DTK----DYGPFSVTLSDEQVLTDYTVRKMHVK
  .     .|  .|. . |.  . | .......
pkekvkledgkikvlalseekeegyiltrlrle
subfamily_PTPN1_pd Subfamily PTPN1 724-876 9.5e-29 95.0 In-house 17-166 (290) alignment 
Range on Protein: 724-876
Range on HMM: 17-166/290.0
SGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGK
   ||.....  .|.|. |||. ..  ||  ||.|.      .  |.||||  ..    . .|| ||||..||   ||...|...|  .||. ...|...
keasdfptreaklpenrnlnryrdvspydhsrikle......radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeq

MKCQQYWPDSDT-----KDYGPFSVTLSDEQVLTDYTVRKMHVKVLeqVTQRPDEVTH
.||.||||  .       .   ..|.|  |..   ||||..... |   ||.  |..|
ikcaqywPqgeeekellledtklkvkliseerksyytvrllelenl..ktqetreilh
0041856 (Phosphotyrosine protein) phosphatases II 882-1096 1.6e-28 94.9 In-house 1-156 (182) alignment 
Range on Protein: 882-1096
Range on HMM: 1-156/182.0
NNDRNRLNQFLPPDNYRvplkgeHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCqenendqevCYQYWSNGKlgeynislln
| |.||   .||.|. |      ..||||| .. |.   . ||..  |. .|  .|..|. ....|.||.|.         ...|| .            
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell..........

eeihnagyierkievtndnkagdKQQVKQYQITNWDSTGKMTnPQTILLVIEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDVFQ
                       .... ||. ..|.  |  . ....|  |||...      .  ..||||  |||.....||   . .    | .....
.......................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vslee

VLKSQRIQKPGSVQT
..|  | ..||.|.|
avklvrsrRpgmvit
0051429 (Phosphotyrosine protein) phosphatases II 905-1096 1.1e-27 92.8 In-house 3-210 (272) alignment 
Range on Protein: 905-1096
Range on HMM: 3-210/272.0
HPDYINAVFINGYKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVMLCQENENDQEVCYQYWSNGKLGEYNISLLNE--------------EIHNA
 ..|||| ...||     ..... .  |. .||..||..  . ....||.|..|.| ... |..|| . ..  ..|    .              |..  
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPqtILLVIEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------V
 || |....|.  .||.  .| ... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVLKSQRIQKPGSVQT
.....  | | ||.|||
eeaveelraqrpgavqt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 879-1096 4.7e-27 89.4 In-house 42-221 (392) alignment 
Range on Protein: 879-1096
Range on HMM: 42-221/392.0
ASQNNDRNRLNQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDqevcyqywsngklge
   |  .|| .. || |. || |       . ||.|| .|.... .||.| ...|   .  .||.|. . |||.|.|. . .| |               
keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...............

ynisllneeihnagyierkievtndnKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMyrtQRKRGNTS--IVVHCSDTVGRSAMFCAAATTINKCK
                          |  |.. | |...|.|   .      ..| .|.|.   . . |. .  ...|||  |||...  .  . . ..|
..........................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsvvahak

TEGVIDVFQVLKSQRIQKPGSVQT
.  ..|||...   | ..|  |||
ktrmvdvfnfvtnirrkrpymvqt
subfamily_CG7180_pd Subfamily CG7180 738-862 1.3e-26 88.0 In-house 41-162 (296) alignment 
Range on Protein: 738-862
Range on HMM: 41-162/296.0
SNKLLNRFANIVVYDDNRITLRPMSGHKDCTneYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKmKCQQYWPDSDTKD
 |.  ||  ..| || ||. |. . |...    |||| |.  .  . .|| |..|. .|. .||||...| .  .|..|.  .  | ....|||    ..
enreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

YGPFSVTLSDEQVLTDYTVRKMHVK
||.. | .  |. ... . |.....
ygeifveiveekqyanlkirtfklt
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 698-862 1.6e-26 87.7 In-house 5-164 (439) alignment 
Range on Protein: 698-862
Range on HMM: 5-164/439.0
DKFGEFVAKGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPS--NKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYIKDYSNQYQYIATQGPVSN
|.| | | | . . .| |.. | ...| . |...   |.    ..  ||. ... .|  |.||. . |       |||| ||| | ..  |||||||  .
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvph..shyinanyikGyyddklyiatqgpkke

TLVDFWRLIWQERSAIIVMITNIIEEGKmkcqqYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHVK
|  |||||....... |||.||..|  |     ||| ..   ||  .|    .  | .|..| ..| 
ttddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 881-1096 3.8e-26 86.8 In-house 2-224 (237) alignment 
Range on Protein: 881-1096
Range on HMM: 2-224/237.0
QNNDRNRLNQFLPPDNYRVPLKGE--HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG----KLG
.|. .||  .    |  || |||     ||||| ...|.    | .| |. |. ..  .||.|. . . . ||||    |.... |..|| .       |
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

EYNISLLNEEIHnAGYIERKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCK
 . .||  .|   . |  | . ...  .  . . ..|||.| |   |   .  ..|    ..    ..    .  ..|||  |||...|    . . ..|
vltvslkkkeef.sdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

TEGVIDVFQVLKSQRIQKPGSVQT
 . |.|... ..|   ..|  .||
ekkvvdiynyvysieedrpyiiqt
subfamily_PTPN14_pd Subfamily PTPN14 877-1097 5e-25 83.1 In-house 42-282 (300) alignment 
Range on Protein: 877-1097
Range on HMM: 42-282/300.0
N--IASQNNDRNRLNQFLPPDNYRVPL---KGEHPDYINAVFING--YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSN
.     .|...|| ...|| .. || |   | .. .||||  |.     ... .|.| .|. .| ..||.|. . .|. |||| .|.|. .| ...|. .
staklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

G-------KLGEYNISLLNEEiHNAGYIERKIEVTNdNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNT--------SIVVHCSDT
        . |.....    | .   .| .....     ......|   | |.|   |   .... |  .||.   .||  ..         ..||||. 
leskkktvefgkfkvttkfse.dsdsvittglklkh.lpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaG

VGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|||. .   .   |.  ... .||. .||.  | |.   |||.
vGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl
0043147 (Phosphotyrosine protein) phosphatases II 904-1096 5.6e-25 83.5 In-house 3-146 (172) alignment 
Range on Protein: 904-1096
Range on HMM: 3-146/172.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQEnendqevcyqywsngklgeynisllneeihnagyierkievtNDNKAG
|. ||||| ....|   . ||.   |. ||   ||.|. ....|.||.|...                                            .. .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpel

DKQQVKQYQITNWDSTGKMtNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkcktEGViDVFQVLKSQRIQKPGSVQT
 .... ||. ..|.  |   ... .| ..| ... . .. .  ..||||  |||.....||   .     .|. .......  | ..||.||.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqn
0049260 (Phosphotyrosine protein) phosphatases II 913-1096 7.6e-25 82.8 In-house 1-135 (152) alignment 
Range on Protein: 913-1096
Range on HMM: 1-135/152.0
FINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWsngklgeynisllneeihnagyierkievtndnkagdkqqvkQYQ
||.||. ...||... |. ||. .||.|. . ..|.||||... |.. . |.||.                                          ||.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

ITNWDSTGKMTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQT
 ..|.  |  ...| .| ... . .  ... .  ..||||  |||.....||   .        ........  | ..||.|..
hlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpn
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 878-1095 8e-25 82.1 In-house 50-267 (290) alignment 
Range on Protein: 878-1095
Range on HMM: 50-267/290.0
IASQNN--DRNRLNQFLPPDNYRVPLK-GEHPDYINAVFINGYKekKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG--K-
|  .|    .||  .    |  || || | . ||. | ...| |    ||... .. .|. ..|.|. . .|.||||||.  |. .  | ||. .   . 
ifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

--LGEYNISLLNEEIHNAGYIERKIEVTnDNKAGDKQQVKQYQITNWDSTGkMTNPQtiLLVIeEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTIn
  .||. .   .|. ..|  | . . |  | ..| . ..| ..|  |     ... .  | ..  . |. ||  .  .|||||  .||.  | |  ... 
ltfGeitvlcseeddkdaniikktlsvr.dkdsGkehklkhlkikswpdks.valst..lall.rtlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.

KCKTEG-VIDVFQVLKSQRIQKPGSVQ
.. ..|  .|. .. .. |  . .|||
qilldGkeldlldlvralrnsrlnsvq
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 908-1096 1.8e-24 81.0 In-house 77-266 (301) alignment 
Range on Protein: 908-1096
Range on HMM: 77-266/301.0
YINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSN-----GKLGEYNISLLNE-EIHNAGYIERKIEVTNDNK
 | | .|.   . . ||.. .|. ||. .|| |.   .|  ||||.|. |. .|.| .| .       ..| ..| . |.  | |   ..|..||..  .
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

AGDKQQVKQYQITNWDSTGkmtNPQTILLVIEEMYRTqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
  . . |  || ..|   |    |..   . . |     |. .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||
kfatrtvthyqysewtdrg...vPkshaelfdlmelv..kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqt
0046846 (Phosphotyrosine protein) phosphatases II 898-1096 2.9e-24 81.2 In-house 4-158 (176) alignment 
Range on Protein: 898-1096
Range on HMM: 4-158/176.0
RVPLKGEHPDYINAVFINGYKekkaFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNgkLGEYNIsllneeihnagyierkievt
|..  ....||||| .| |..    .|.   |. .|  .|..|. . ..||.|.|..| | ..  |..||.   | ...|                    
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi....................

ndnkagdkqqvkQYQITNWDSTGKMTNpQTILLVIEEMYRTQRKrGnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQT
            ||. ..|.  |  .  . .| ..|.... ... |   ..||||  .||.....||      ...|  ..|...|.  | |.| |.|||
............qylhlpwpDhgvpdl.elllellefirealke.g.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 701-847 4e-24 79.7 In-house 15-158 (310) alignment 
Range on Protein: 701-847
Range on HMM: 15-158/310.0
GEFVAKGHAKGNEGFRNQFGMLDSgESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmsGHKDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDF
 .|.      | ||. .|.  ||. . | ..|      .   ||....|. |. |. |.     |   ..|| | |.|    .  .| .|||.  |..||
enfiiateklgieglvkqyrklda.kqdssltyeaykkymhknrysdvvcldtsrvklk...idksryedyihanyvktnylrstficsqgplqhtiidf

WRLIWQERSAIIVMITNIIEEGKMKCQQYWPDS-DTKDYGPFSVTLSD
||.|.|||.  |... .. |||. ||  |||    |. ||   ||   
wrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnls
subfamily_ptpA1_pd Subfamily ptpA1 706-861 6.9e-24 79.3 In-house 14-164 (418) alignment 
Range on Protein: 706-861
Range on HMM: 14-164/418.0
KGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGhKDcTNEYINACYIkDYSNQYQYIATQGPVSNTLVDFWRLIW
| | |     ...| .|.        . |    |   ||..||.  .  |. |. .   |.  ..|||| || | .   |.|.||||. ||. ||||..|
knhikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqd.ke.gsdyinanyi.dgaypkqfictqgplpntiadfwrmvw

QERSAIIVMITNIIEEGKMKCQQYWPDSDTKDygPFSVTLSDEQVLTDYTVRKMHV
..|  ||||..   |. ..||..|||.    .   ||.    ..|.  |.|  . |
enrcriivmlsresencrikcdrywpeqigge..qfsiygngnevfgtysvelvev
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 738-837 7e-24 79.2 In-house 32-129 (297) alignment 
Range on Protein: 738-837
Range on HMM: 32-129/297.0
SNKLLNRFANIVVYDDNRITLRPMSGHKDctneYINACYIK--DYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDT
|    ||. .|. .||.|. |.     .|    |||| |.   |  ....|| .|||.|.|. |||.|....   .|||.... |.|. ||  |||... 
sslrknryrdilatddtrvkllrviterd....yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

KD
. 
er
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 724-887 1.1e-23 78.5 In-house 34-195 (350) alignment 
Range on Protein: 724-887
Range on HMM: 34-195/350.0
SGESDHTVTVGLTPSNKllNRFANIVVYDDNRITLR----P--MSGHKDCTNEYINACYIKDY------SNQYQYIATQGPVSNTLVDFWRLIWQERSAI
|   |  .. |.    |  ||. ||. |. .|. |.    .     |   ||.|||| |.|          ...|||||.|. .|. ||...| .    .
spsnDvilseGvelfak..nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkv

IVMITNIIEEGKMKCQQYWPDSDTKDygpFSVTLsdeqvltdyTVRKMHVKVLEQVTQRPDEVTHNIASQNNDRNR
|...|. .| .  ||..||.. . .|   . | |         . ..  .   ....... .| .. .  .|. . 
ilsltsdvelnlekcyrYWqegsydd...itvkl.........askwenimgindsslysadvkkeasdndnisdd
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 695-836 2e-23 77.5 In-house 4-148 (392) alignment 
Range on Protein: 695-836
Range on HMM: 4-148/392.0
IPVDKFGEFVAKGHAkgNEGFRNQFGMLDSGESdHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYIKDYSNQYQYIATQGPVS
||| .|  || | .   .  | ..|  | . .  .  ||. .. |.  ||. ||. || .|. |  .    |  ..|.|| ||. . |.  |||.||| .
ipvaqfpafveknrh..salffeefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddipd..sdylnasyipsfdnekayiasqgpna

NTLVDFWRLIWQERSAIIVMITNIIEEGK----MKCQQY----WPDSDTK
 .| ||||...||. . |.|.|.. |  |      . |.    |||.|  
aslddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewPdkdvp
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 854-1096 3.1e-23 77.2 In-house 13-262 (307) alignment 
Range on Protein: 854-1096
Range on HMM: 13-262/307.0
YTVRKMHVKVLEQVTQRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLK--GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVM
  |...  .  .   . |. || .  | |.|.|| ..    |. |. .|  |   ||| | ..    . | || |. |. ||  .|| |. . .| ...|
kgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim

LCQENENDQEVCYQYWS--NGKLGEY-----NISLLNEEIHNAGYIERKIEVTNDN--KAGDKQQVKQYQITNWDSTGkmtNPQTILLVIEEMYRTQRKr
||.  |  .  | |||   .|.   .      ||. |  ...    |  |.||. .   |.. . ....| .||   |    ||. |  |. .  .. . 
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrg...vpqinltainlleavryd.

gNTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQT
 .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..||
.tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqt
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 884-1096 4.2e-23 76.7 In-house 10-226 (239) alignment 
Range on Protein: 884-1096
Range on HMM: 10-226/239.0
DRNRLNQFLPPDNYRVPLK----GEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWS--NGKLGEYN
 .||  . .  |  || |.      | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||     |  .  
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

ISLLNEEIHnAGYIERKIEVTNDnKAGDKQQVKQYQITNWDSTGKMTNpQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV
..| . |.  | || | . ...     ... | ||..| |   |      | .| .      .   |    |.|||  |||.  |    . . ..| .  
vtlrktevf.adyiirtfvmsqv.gqteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

IDVFQVLKSQRIQKPGSVQT
.|.|. .|. | ..|  |||
vdifnyvkairedrphmvqt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 884-1096 4.2e-23 76.7 In-house 9-225 (239) alignment 
Range on Protein: 884-1096
Range on HMM: 9-225/239.0
DRNRLNQFLPPDNYRVPLK----GEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWS--NGKLGEYN
 .||  . .  |  || |.      | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||     |  .  
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

ISLLNEEIHnAGYIERKIEVTNDnKAGDKQQVKQYQITNWDSTGKMTNpQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV
..| . |.  | || | . ...     ... | ||..| |   |      | .| .      .   |    |.|||  |||.  |    . . ..| .  
vtlrktevf.adyiirtfvmsqv.gqteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

IDVFQVLKSQRIQKPGSVQT
.|.|. .|. | ..|  |||
vdifnyvkairedrphmvqt
subfamily_CG42327_pd Subfamily CG42327 737-876 9.2e-23 75.4 In-house 26-166 (319) alignment 
Range on Protein: 737-876
Range on HMM: 26-166/319.0
PSNKLLNRFANIVVYDDNRITLRpMSGHKDcTNEYINACYIKDYSN-QYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDT
.. |  .|..|.|   . |..|.   | .|  .||..| |.. | . . .|||.| .  ..  ||||..|. .| .|| .|.. | |  .| .|.| ..|
vtskdksrvinvvPlPetrvvlq.rigddd.kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket

KD----YGPFSVTLSDEQVLTDYTVRKMHVKVLEQVTQRpdEVTH
 |    || . ||| . .|   | .  . .| ...   |  |.||
ldntslyGdilvtlkgrevkdryaistlllkrvdkeesr..elth
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 878-1095 2e-22 74.3 In-house 42-263 (439) alignment 
Range on Protein: 878-1095
Range on HMM: 42-263/439.0
IASQ--NNDRNRLNQFLPPDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENEndqevCYQYWSNGK
.|.|  .. .|| ..  . |  || |       |  |||| .|.|| ..| .| .. |  .|. .||... ..... ||||..  |      |.||   .
laaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve.....sykywpsda

LGEY-NIS-LLNEEIHNAGYIERKIEVTNDNKAGDKQ-QVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTI
   | .|.   . .|    |. | . | |.   ..|.  | |.. . |      ..   .|  .  .  .. |.    .|||||  |||.    |   ..
evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdial

NKCKTEGVIDVFQVLKSQRIQKPGSVQ
.. |.|  .|.  ..|  | |.   ||
eqlklenkvdikgivkvlrkqrkqmvq
0049772 (Phosphotyrosine protein) phosphatases II 881-1088 5.7e-22 74.3 In-house 45-255 (314) alignment 
Range on Protein: 881-1088
Range on HMM: 45-255/314.0
QNNDRNRLNQFLPPDnYRVPLKG---EHPDYINAVFINGYkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVM--------------
 | |.||  ..|| |  || |.|   .  ||||| ...|.   ..||... |. .|  .|          |.|.  .|.||  |||              
lnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCQENENDqevcyqywsnGKLGEYNISLLNeeihnagyierkiEVTNDNKAGdKQQVKQYQITNWDStGKMTNPQTILLVIEEMYRTqrkRGN
       |..  .|           . . . .. ||.             |...|..   .... .|  ....  |    .. .. ..| . .    . .
aAlgKtpllildgng..........neptaadlellk.............eelydpelf.erlgikylripvpD.gsaplledfdeflefieea...dkg

TSIVVHCSDTVGRSAMFCAAATTINKCKTeGVIDVFQVLKSQRI
. ..|||.. .||.. |..||  . ...   . .... ....| 
gpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 714-849 9.9e-22 71.9 In-house 12-148 (281) alignment 
Range on Protein: 714-849
Range on HMM: 12-148/281.0
GFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHKDCTnEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIV
 |...|  |        .||   | |.  ||..|| . |  |. |.     |. | .|| | ||.    .  || ||||  .|  ||||.|||| .. ||
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknst.dyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MITNIIEEGKMKCQQYWPDSD--TKDYGPFSVTLSDEQ
|. ...|  . || .|.|       ..  .||.  |  
mlcqfletnrekcaeyfprnahcclqfdklsvsyedst
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 743-859 4.5e-21 69.7 In-house 60-171 (290) alignment 
Range on Protein: 743-859
Range on HMM: 60-171/290.0
NRFANIVVYDDNRITLRpmSGHkdcTNEYINACYIKDYSNqyQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTK--DYGP
||. ..|  |  |. |.   |.     .|. | |.|       .| |||.. .| .|.||.. ||. | |||. ..||.|| ||.||.|. . .   .| 
nrykdvvcndktrvilk..dGy...dGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

FSVTLSDEQVLTDYTVRKM
..|. | |.   . ...|.
itvlcseeddkdaniikkt
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 704-836 2.2e-20 67.9 In-house 7-134 (307) alignment 
Range on Protein: 704-836
Range on HMM: 7-134/307.0
VAKGHAKGNEGFRNQFGMLDSGEsDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmsgHKDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRL
| .   || . ....| .|   .  ..|||    .|   ||. .. . | .|| ..     .  . .|| | |.    .  ..|..|||  ||  .|| .
vqrtldkgvqalvdefrvlakkt.pegvtveafsantdknryqdvkcqdkgrivvk....fdglasdyihanylgiaikpkkficaqgplentqysfwam

IWQERSAIIVMITNIIEEGKMKCQQYWPDSDTK
. ||.   ..|. ..|| .|.||.||||  . .
aiqekvesvimlckvielakikceqywpleegq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 872-1096 2.6e-20 67.6 In-house 30-256 (288) alignment 
Range on Protein: 872-1096
Range on HMM: 30-256/288.0
DEVTHNIAS---QNNDRNRLNQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWS
.| . .|..   .|  |.| ..    |  || |. .   ||.|  .   | |. .| |..|.  |  ..|||. . .|  |||||.  |  .|   .|. 
neasidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfP

NGKLGEYNISLLNEEI-HNAGYIERKIEVT--NDNKAGDKQQ-VKQYQITNWDSTGKMTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAA
  .  .  |  |   . ..   |.. ..|.  . .| |.... ||.  . .||  |   | .. | ..| .     |  .  ||||.|  |||.. .   
sklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlili

ATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
   ..  . .  . . ..|.. | ..  ..||
lialeslrlddflgirsllaklreerfkaiqt
0051082 (Phosphotyrosine protein) phosphatases II 905-1096 1e-19 66.1 In-house 2-138 (151) alignment 
Range on Protein: 905-1096
Range on HMM: 2-138/151.0
HPDYINAVFINGYkekkaFIIAESPmfntARNFWKMIDDRNVTAIVMLCQENENDqeVCYQYWSN-Gklgeynisllneeihnagyierkievtndnkag
..||||. .. |.     ...   |       |.... . ....||.|..| |..   |..|. . |                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

dkQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQT
   .|....|..|. .|  ......| ..|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||.
..ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp
PTPc_DSPc_SM00012 1007-1096 1.4e-19 65.6 In-house 1-92 (105) alignment 
Range on Protein: 1007-1096
Range on HMM: 1-92/105.0
QVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQT
.||.|..|.|  .|. .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.|||
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqt
subfamily_ptpA1_pd Subfamily ptpA1 863-1070 2.7e-19 64.2 In-house 29-255 (418) alignment 
Range on Protein: 863-1070
Range on HMM: 29-255/418.0
VLEQVtQRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKG----EHPDYINAVFINGYKEkKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENEN
.||.    | | .     .|  .||  . || .  || ||     |  ||||| .|.|    | || .. |. ||  .||.|. .  .  |||| .|.||
llees.vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresen

DQEVCYQYWSNGKLGEyNISLL--NEEIHNAgYIERKIEVTNDN------------KAGDKQQVKQYQITNWDSTG--KMTNPQTILLviEEMYRTQ---
 .  | .|| .   || ..|.    .|.  . |    .|| .|               |. ... |||   |        |.|   ||    .   |   
crikcdrywpeqigge.qfsiygngnevfgt.ysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqll..hsitnrqnqi

--RKRGNTSIVVHCSDTVGRSAMFCAAATTINK
      |  |.||||  |||.  ||.|   ..|
ipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 729-863 3.9e-19 63.7 In-house 23-150 (267) alignment 
Range on Protein: 729-863
Range on HMM: 23-150/267.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEgkmKCQQ
 |..  ..  |.  ||. . . |||.|. ||      . ..||||| |.. |  . ..|.||.|..||  ||. .| ... ..||..|.. ..   . ..
stisqsiaeknqernrlddnlpyddtrvilr......tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirl

YWPDS--DTKDYGPFSVTLSDEQVLTDYTVRKMHVKV
.||    ..| |  ..|  | |.   || .  . .|.
fwPPkmgqakkyqdltvehslekeendyqiitlelkf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 702-837 6.2e-19 62.9 In-house 11-140 (305) alignment 
Range on Protein: 702-837
Range on HMM: 11-140/305.0
EFVAKGHAKGNEGFRNQFGMLDSGESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHkdctnEYINACYIKDYSNQYQYIATQGPVSNTLVDFW
.|| .   || .|.|..|  .   .  . .       ..  ||. ..   |.||. |..   |     ||| | |.   .|  ..| || |. .|  |||
kfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwph.....eyihanyvstptnpkrfictqaplektcadfw

RLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDtKD
 . .|..   | |. |..| |  ||..|..  | ||
ymclqdkveaifmlcnllekgakkcleyfaskd.kd
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 869-1094 7e-19 62.9 In-house 22-253 (285) alignment 
Range on Protein: 869-1094
Range on HMM: 22-253/285.0
QRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKGEHPDYINAVFIN-GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYW
  | ..|.     | | ||  .    .. || ||    ||| | ..    |.. ..| .. |. .|  .||.|| . ... ..|||   |   | |  |.
ymppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

SN-----GKLGEYNISLLN-EEIHNAGYIERKIEVTNDNKAGDKQ-QVKQYQITNWDSTgkmTNPQTILLVIeEMYRTQRK--RGNTSIVVHCSDTVGRS
 .      |.|.|.|.| . .|   || |   . |.| . |  .   ... |.  |        |.    .| |.|.  .|    .. |.||||  |||.
peklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdq...lapedarpmi.elykwvkkvnpkekpicvhcsagvgrt

AMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSV
| |     .  .   .  |.......  |  .  .|
atfvgidyatirimenpniemldivremramrfqav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 880-1096 1.8e-18 61.2 In-house 35-254 (281) alignment 
Range on Protein: 880-1096
Range on HMM: 35-254/281.0
SQNNDRNRLNQFLPPDNYRVPLKG-----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGKLGE
  || .||  .    |  || ||      .  ||| | .|     |. .|... |  .|  .||.|| . | ||||||||  | ..| | .|.       
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

YNISLLNEEIHNAgYIERKIEVTND--NKAGDKQQVKQYQITNWDSTgKMTNPQTILLvieEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCK
 ..  |  .  ..  ... .  |       |. . . ..   .|    .. .   ..|   .. |  | |  |  |.|||  ||||  . |   ...  .
lqfdklsvsyeds.tvnkslvttrlnlsyegetrlithwlwkewpdw.qvpessevml...kilrkirar.stppvihcsagvgrsgtlmaveialqsih

TEG-VIDVFQVLKSQRIQ-KPGSVQT
.   . |. |..   |.  .  ||||
shftlpdikqivshlrvtgraasvqt
0044763 (Phosphotyrosine protein) phosphatases II 904-1093 2.7e-18 61.7 In-house 16-153 (178) alignment 
Range on Protein: 904-1093
Range on HMM: 16-153/178.0
EHPDYINAVFINGYkekkaFIIAESPMfntaRNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGKLgeynisllneeihnagyierkievtndnkag
|  |||||..| ..     ....  |.     ...... . ..|.||.|..| |. .. |..||  .                                 
ersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...............................

dkqqvKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgS
      ||. ....  |  . .. .| ..| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  
.....iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.i
0051429 (Phosphotyrosine protein) phosphatases II 769-865 2.9e-17 58.7 In-house 4-114 (272) alignment 
Range on Protein: 769-865
Range on HMM: 4-114/272.0
NEYINACYIKDYsnqYQ------YIATQGPVSNTLVDFWRLiWQERSAIIVMITNIIEEGKMKCQQYWP------------DSDTKDYGPFSVTLSDEQV
. |||| ... |   ..      .....||  .|  ||||| ....   ||....  | |. || .|||            .  |  || ..|||  |..
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LTDYTVRKMHVKVLE
|.||..|.. .. | 
lldyilrellltlll
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 882-1095 9.3e-17 55.6 In-house 55-273 (305) alignment 
Range on Protein: 882-1095
Range on HMM: 55-273/305.0
NNDRNRLNQFLPPDNYRVPLKGEHP-DYINAVFING-YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSN--GKLGEYNI
.  .|| ..    |.  | |.   | ||| | ..      .| || |. |. .|  .|| |. ...|  |||||.  |  .  | |||    |.  | . 
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks

SLLNEEIHNAGYIERKIE--VTNDNK---AGDKQQVKQYQITNWDSTGKmtnPQTILLVIEEMyRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
 .. |..  .  .||  |  .|  |     ..|  |.. | |.|   |    |   |  .| .  . |   .  ||||||  .||.    |    ..|  
givvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv...ppckltslell.sair.gskvpivvhcsagigrtgtivaieyilekia

TE-GVIDVFQVLKSQRIQKPGSVQ
 .  .  . ...|. | |.  |.|
enkpcppmpelvkalrdqrafsiq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 738-846 1.4e-16 55.3 In-house 34-139 (285) alignment 
Range on Protein: 738-846
Range on HMM: 34-139/285.0
SNKLLNRFANIVVYDDNRITLrpmsghKDCTNEYINACYIKDY-SNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDS--D
.|  |||.|.. . .. |. |      |.   .|| | ...    .|  ||.||||. .|| |||..|.||. | ..|.  ..| |  ||  |.|.   .
anpdlnryadvrcieetrvvl......knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

TKDYGPFSVTLS
   .| . .||.
vvkfgkyeitlt
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 880-1096 3e-16 54.0 In-house 46-272 (305) alignment 
Range on Protein: 880-1096
Range on HMM: 46-272/305.0
SQNNDRNRLNQFLPPDNYRVPLKGEHP-DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGKLG-----
.|....||  .    || || |.|  | .|| | ..    . | || ...|. .|  .|| |  . .| || |||.  |   . |..|..  .       
aqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

--EYNISLLNEEIHNAGYIE------RKIEVTNDNKAGDKQQVKQYQITNWDSTGKMTNPQTIllvIEEMYRTQRKRGntSIVVHCSDTVGRSAMFCAAA
  .  ||.  |  ..  . .      .. ... .   .....|..|   .|   |  .  ..|   .| . ...  .|   ||||||  .||.       
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlai...lellekarpskg..pivvhcsagigrtgsvvmle

TTINKCKTEGVID-VFQVLKSQRIQKPGSVQT
  ...  .  .|.   ..|.  | |.  |.||
yildqllagqiiedtdkilqkireqrnnsiqt
0049772 (Phosphotyrosine protein) phosphatases II 727-842 7.5e-16 54.2 In-house 34-168 (314) alignment 
Range on Protein: 727-842
Range on HMM: 34-168/314.0
SDHTVTVGLTPSNKLLNRFANIVVYDdNRITLrPMSGHKDCTneYINACYIKDYsnqYQYIATQGPVSNTLVDF----------WRLI--WQERSAIIVM
...|..|.  . |.  ||. .|. .| ||  | |  .....   |||| |.. .    ..|||||| ..|.|||          ||..  .. .. .|||
peltilvadlflnrdknryldilpad.nrvil.pglpvsgsd..yinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------ITNIIEEGkmkcqQYWPDSDTKDYGpfS
                     .... . |      ... .| ...   .
srdevladelsrLdaAlgKtpllildgng.....neptaadlellk..e
subfamily_egg_pd Subfamily egg 728-836 7.6e-16 52.6 In-house 29-133 (307) alignment 
Range on Protein: 728-836
Range on HMM: 29-133/307.0
DHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHkdCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEgkMKCQ
. ..|  ..  |.   |   .   |  |..|.   |    ....| | ..|      ..| .| |. ||  ||||...||.   |||.|   |    .|.
eislttaasdnnlekarskrvhckdssrvklelrrGq..ylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPDSDTK
 ||| ....
yywpkaesd
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 870-1090 9.8e-16 52.2 In-house 40-269 (310) alignment 
Range on Protein: 870-1090
Range on HMM: 40-269/310.0
RPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLK---GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQY
.   .|..   ..  .||  . .  |. || ||     . ||| | ...    ...|| .. |.  |  .||.|| .    .|..||.  |. .  |  |
qdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WSNGKLGE-Y---NISLLNEEIHNAGYIERKIEVTNDNKAGDKQQVK--Q--YQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNtsIVVHCSDTVGRS
|    . | |    .. |.|  ..    .  .    ||   |.|  .  .   .. .|     .  |.     . .   .| . |    |||||  ..| 
wpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgp..cvvhcsagkdrl

AMFCAAATTINKCKTEGVIDVFQVLKSQRIQK
 . .|   .|.| .    .|. .|    . ..
yvvvalklkidkldrglkvdaeevktellksr
0041856 (Phosphotyrosine protein) phosphatases II 739-836 2e-15 52.3 In-house 1-77 (182) alignment 
Range on Protein: 739-836
Range on HMM: 1-77/182.0
NKLLNRFANIVVYDDNRitlrpmsghkdcTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITniieegkmkCQQYWPDSDTK
|. .||. .|. || .|             . |||| ..  .  . ..||||||  .|. ||.|......  .||..|         . .|||.  ..
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpeller
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 926-1096 2.4e-15 50.8 In-house 96-273 (302) alignment 
Range on Protein: 926-1096
Range on HMM: 96-273/302.0
AESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG-----KLGEYNISLLNEEIHNAGYIE------RKIEVTNDNKAG-DKQQVKQYQI
   |  .|   .| .|.. ||. .| ||.  |.... | .|.|.      |.|.| .  .. . . . . .       ..|..|..|    |. |.  . 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWDSTGKMTNPQTILLVIEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
. |   |   ...| | ..   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||.
sawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 906-1087 2.5e-15 51.4 In-house 46-235 (290) alignment 
Range on Protein: 906-1087
Range on HMM: 46-235/290.0
PDYINAVFINgYKEKKAFIIAESPMFNT-------ARNFWKMIDDRNVTAIVMLCQENENDQE----VCYQYWSN--G---KLGEYNISLlNEEIHNAGY
 ||| | ..  . .  ..|. .||  ..         .|| |. . .|. .||||. .|....     | .|  .  |   |..  ...   . ... . 
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.kskekeddv

IERKIEVTNDNKagDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQR
..|...|. |..   . .|. ... .|...    ...|.| .|. .     |  .| ..||| | . |||.. |      |   |.| . . .|||. |
etRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 741-833 1e-14 48.9 In-house 57-145 (305) alignment 
Range on Protein: 741-833
Range on HMM: 57-145/305.0
LLNRFANIVVYDDNRITLRPMSghkdcTNEYINACYIK-DYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDS
  ||.... . | . . |   |       .|| | |.      . ..|..|||. .|. .|| .. |..   |||. . .| ||.|| |||| .
tknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 881-971 2.9e-14 47.6 In-house 30-126 (297) alignment 
Range on Protein: 881-971
Range on HMM: 30-126/297.0
QN--NDRNRLNQFLPPDNYRVPLKGEHP--DYINAVFINGYKEKK--AFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGK
.|    .|| .. |  |. || |..  .  ||||| ..   .|..   .|.|. |. .|  .||... ...| .|||... .|. .. |. || . .
rnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv
I-set Immunoglobulin I-set domain 584-672 4e-14 44.2 Pfam-A 1-90 (90) alignment 
Range on Protein: 584-672
Range on HMM: 1-90/90.0
PVIEEFPNDMTSEEGRQVLFKVKvkVRGNSKPSFNWYHNGEPVTDDYAHELRGDG---SLLLVSVEKKHKGTYRFVANNDAGTVSQQVVLTV
|.... ..|.. .|| .| ....  |.|. .||..|...|.... .  .... ..   .| . .||.. .|.|. .|.| ||...... |.|
pkftqklkdvevseGesvelect..veGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
fn3 Fibronectin type III domain 120-202 5.3e-14 45.3 Pfam-A 2-82 (85) alignment 
Range on Protein: 120-202
Range on HMM: 2-82/85.0
PVDDIIFSSVESVSMTVSWDEVPcnGRNGPITGYYLTYTNITSNT-SYTVNITGGENrMYNLTGLIPYTNYTVSIIPYNYNMTG
.. .. .|.| | |.|.||.. .   ..|||||| ..| . ...  . ...... ..  ..|||| |.|.|....  .| . .|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngageg
subfamily_egg_pd Subfamily egg 873-1094 6.3e-14 46.3 In-house 31-253 (307) alignment 
Range on Protein: 873-1094
Range on HMM: 31-253/307.0
EVTHNIASQNNDRNRLNQFLPPDNYRVPLK---GEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENdqEVCYQYWS
 .|. ... | .. | ..    |  || |.   | .  |.| |  ..|      ||.|..|. ||  .||.|.   .|  ||||    |.  | |  || 
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

NGKLGEYNI---SLLNEEIHNAGYIERKIEVTNDNKAGDK---QQVKQYQiTNWDSTGKMTNPQTILlvieemyRTQRKRgNTSIVVHCSDTVGRSAMFC
. .     .   ||  | ..     .    ||. .  | .   . .. .|  ... ....  |  .|       |  |.   . .||.. . | ..| . 
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysplrvl.......rklrnl.skpvvvqdilGvskaatlv

AAATTINKCKtEGVIDVFQVLKS---QRIQKPGSV
|. ... .    | |  . ||..    | ... ||
aieiallsll.rGpitkslvlravvflrlrrrlsv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 740-883 6.4e-14 46.4 In-house 44-176 (312) alignment 
Range on Protein: 740-883
Range on HMM: 44-176/312.0
KLLNRFANIVVYDDNRITLrpmSGHkdcTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWpdSDTKDYg
| |||. || ..|  |.||   .|     | || | ..|  ..  ....||||. || . ||.|     |. |.... ..|.|  || .|   ||   . 
kdlnrypniqcwdrgrftl...agd...enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi..sdivgf.

pfsVTLSDEQVLTDYTV-RKMHVKVLEQVTQRPDEVTHNIASQNN
   | | | .| |.|    ..  |  ...|.|   |  . . |. 
...vdledhrvyteycteieiggkskdkithrvlkvvvkatgqes
fn3 Fibronectin type III domain 228-297 9.1e-14 44.6 Pfam-A 13-84 (85) alignment 
Range on Protein: 228-297
Range on HMM: 13-84/85.0
PTEIIIVWNPPTIPNGIITVYEIRYRESTSTG-PYNITNTTNT-YYSIVGLIPNTSYTIGVRAYTSIGPGEW
.|.. . |.||. ..| || ||..|||..... . ..|.. .|  . . || |.|.|.. |.|..  | |..
stsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_hpo-7_pd Subfamily hpo-7 925-1067 1.1e-13 45.7 In-house 42-177 (263) alignment 
Range on Protein: 925-1067
Range on HMM: 42-177/263.0
IaespMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG---KLGEYNISLLNEEIHNaGYIERKIEVTN--DNkAGDKQQVKQYQITNWDST
.    . .|  .|...|   . . .||||  ||...| | .|.      |.   |...   .. .   . . .|...  ..     ..||.|. . |  .
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlge.KkkthtvkhysykgWiek

GKMTNPQTILLVIeemyRTQRKRgnTSIVVHCSDTVGRSAMFCAAATT
   .... || ..    .  |.    |.|||||  .|||| |  | . 
ndpelareilnil....kvarns..kslvvhcstGiGrsaafsvaElv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 925-1067 1.4e-13 45.5 In-house 39-171 (255) alignment 
Range on Protein: 925-1067
Range on HMM: 39-171/255.0
IaespmfnTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGKLGE---YNISLLNEEiHNAGYIERKIEVTNDNK-AGDKQQVKQYQITNWDSTG
.       |  .|...|   . . .||||  .|...| | .|.   | .     ....   .   |  . | .|.|         ..|| |. . |    
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWiekn

KMTNPQTILLVieemYRTQRKRgnTSIVVHCSDTVGRSAMFCAAATT
   ... || .    ..  |.    |.|||||  .|||| |  |   
aPelareilni....lkvvrds..ksvvvhCstGiGrsaafvlaelv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 771-868 2.1e-13 44.7 In-house 77-176 (301) alignment 
Range on Protein: 771-868
Range on HMM: 77-176/301.0
YINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSD--TKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQVT
 | | .|.   .  ..||||||..||  ||| .. |     |||... .|. . ||..| | .   . | | |.... ..... .  . | ...| .   
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 872-982 2.7e-13 44.4 In-house 38-165 (350) alignment 
Range on Protein: 872-982
Range on HMM: 38-165/350.0
D-EVTHNIasQNNDRNRLNQFLPPDNYRVPLK------------GEHPDYINAVFINGY----KEKKAF--IIAESPMFNTARNFWKMIDDRNVTAIVML
| .... .  .   .|| .. || .  || ||             .  ||||| ...      . .  |  | . .|. .|  .|.|.|   .|. |..|
DvilseGv..elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

CQENENDQEVCYQYWSNGKLGEYNISLLNE
 .. |.. | ||.|| .|.  .... | . 
tsdvelnlekcyrYWqegsydditvklask
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 869-1028 4.6e-13 43.4 In-house 81-242 (244) alignment 
Range on Protein: 869-1028
Range on HMM: 81-242/244.0
QRPD--EVTHNIASQNNDRNRLNQFLPPDNYRVPLK-GEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQevcy
 |||   .   .  .|. .||    || |  ||||  |     |||| |.        .|... |. .|. .||||. .| |  .|.|   .|.|.    
irpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede....

qYWSNGKLGEY---NISLLN---EEIHNAGYieRKIEVTNDNKaGDKQQVKQYQITNWDSTGKMTNPQTI
 || . .  |.   .|..     .|..|      ..|.  | .   .| .  .||.|| | |   |   |
.ywpdseplewyeeditvtltdrdefknika..snleiesdmn.eshqaltmfqisnwpsdgttpndhfi
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 883-1089 5.4e-13 43.3 In-house 44-257 (312) alignment 
Range on Protein: 883-1089
Range on HMM: 44-257/312.0
NDRNRLNQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNG----KLGEYNIS
.| ||  .    |  |  | |.   || | |..     . |.....|. ||. .||..      |.|..||   |.  | | .| |.     .| .. . 
kdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvy

-LLNEEIHNAGYIERKIEV----TNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAA---TTINK
     ||   |    ||         . .|.. ....|| . |   |     .| | ..  .     |. .  .. |||  |||.  ..      ... .
teycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrh

CKTEGVIDVFQVLKSQRIQ
 . . | |.| .|. .| .
prkqnvkdsfvllrkdrar
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 734-847 1.1e-12 42.1 In-house 91-197 (244) alignment 
Range on Protein: 734-847
Range on HMM: 91-197/244.0
GLTPSNKLLNRFANIVVYDDNRITLRpmsgHKDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEgkmkcQQYWPDS
 . |.|   || .  . .| ||. |     .    | |||| ..       .|| || |...| .|||... .    ..|..  . ||     ..|||||
afnpnnswknregaglpfdfnrvpls....kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpds

DTKDYG--PFSVTLSD
.  ..     .|||.|
eplewyeeditvtltd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 724-845 1.2e-12 41.9 In-house 35-165 (349) alignment 
Range on Protein: 724-845
Range on HMM: 35-165/349.0
SGESDHTVTVGLTPSNKllNRFANIVVYDDNRITLR----PMSGHKD-------C-TNEYINACYIK--DYSNQYQYIATQGPVSNTLVDFWRLIWQERS
|   |  .. |.    |  ||. .|. |.  |. |.    .  . |        .  ..|||| |.|   .| . .||||| |.  |. ||...|  .. 
seiddvilseGvelfak..nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngv

AIIVMITNIIEEGKMKCQQYWPDSdtkDYGPFSVTL
 ... ...  |..  ||..|| .    .|  . | |
klvlsLnddkelslekcdiywqel...sysnitvkl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 918-1093 1.2e-12 42.4 In-house 2-186 (199) alignment 
Range on Protein: 918-1093
Range on HMM: 2-186/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGKL--GEY-NISLLNEEIH-NAGYIERKIEVTNDNKAG-DKQQVKQYQ
| .. .| .. |. .|  .||.|. .     |||. ... | .     ||.  .   |.| ..|.  . |  .. |    . .||.  |    ... .||
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

ITNWDSTgkmTNPQTIL-----LVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGS
.| |      | |.  |     .   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | 
ftswkek...ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgi
subfamily_CG42327_pd Subfamily CG42327 866-1029 1.6e-12 41.8 In-house 16-184 (319) alignment 
Range on Protein: 866-1029
Range on HMM: 16-184/319.0
QVTQRPDevthNIASQNNDRNRLNQFLP--PDNYRVPLKGEHP--DYINAVFINGYKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQ
|.  | |    ..    .|..|. . .|  . .  .. .|...   |..| .. ||.. .. .| |. .. ... .||... ...   || |..  |.  
qliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGi

EVCYQYWSNGK-------LGEYNISLLNEEIHNAgYIERKIEVTNDNKAgDKQQVKQYQItNWDSTGKMTNPQTIL
.|| .|.   .        |.. ..| . |...  |.   . . . .|    ...  |   .|  ..  .......
kvcaeylPtketldntslyGdilvtlkgrevkdr.yaistlllkrvdke.esrelthywy.kwleaevPaeeaali
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 919-1093 1.7e-12 42.0 In-house 2-185 (198) alignment 
Range on Protein: 919-1093
Range on HMM: 2-185/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGKL--GEY-NISLLNEEIH-NAGYIERKIEVTNDNKAG-DKQQVKQYQI
 .. .| .. |. .|  .||.|. .     |||. ... | .     ||.  .   |.| ..|.  . |  .. |    . .||.  |    ... .||.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWDSTgkmTNPQTIL-----LVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGS
| |      | |.  |     .   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | 
tswkek...ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgi
0046846 (Phosphotyrosine protein) phosphatases II 769-840 2.6e-12 42.3 In-house 12-79 (176) alignment 
Range on Protein: 769-840
Range on HMM: 12-79/176.0
NEYINACYIKDYsnqyQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGP
  |||| .|  .     .||||||. .|| ||........  ..|..|. .| |. || .|||.  . ..  
ldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 880-1096 3.4e-12 40.4 In-house 49-270 (302) alignment 
Range on Protein: 880-1096
Range on HMM: 49-270/302.0
SQNNDRNRLNQFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTA---RNFWKMIDDRNVTAIVMLCQENENDQeVCYQYWS--NGKLGE
 .| ..|. ...  .|. .| |..|  .|.||  ..  . ..  |.|  |  ...    .||.|. ..... .|.| .|.| ..    ...    |.  |
kknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyke

YNISLLNEE----IHNAGyIERKIEVTNDNKAgDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINK
|.   .|       ...   .  |||  .. . .   .. | .||| ..   ..  ..   .....      .. ..|.     .|| ..| ..|....|
ygkmfvNnrkVekaeeek.tryviEvlPegcs.nsvlanvyvltnWkqkkvpvkyaeliktaakvfak.kikadentvivSknGaGRagafltlavavek

CKTEGVIDVFQVLKSQRIQKPGSVQT
 ...    . ...|| | |.| .|..
lqkgkepnikeivksiRsqRpravds
0049260 (Phosphotyrosine protein) phosphatases II 777-857 1.2e-11 40.0 In-house 2-56 (152) alignment 
Range on Protein: 777-857
Range on HMM: 2-56/152.0
IKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWpdsdtkdygpfsvtlsdeqvltdytvR
|. | .....|||||| .||| ||||....    .|||.|.  | || || ||.                          .
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................q
0036282 (Phosphotyrosine protein) phosphatases II 769-850 1.3e-11 40.0 In-house 2-61 (174) alignment 
Range on Protein: 769-850
Range on HMM: 2-61/174.0
NEYINACYIKDYSNQYQYIATQGPVSntlvdFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDsdtkdygpfsvtlsdeqV
. |||| ... .     .||.||| .     ||........ ..|| .. .| |. || .|||.                  
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................l
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 739-832 1.5e-11 38.9 In-house 43-130 (288) alignment 
Range on Protein: 739-832
Range on HMM: 43-130/288.0
NKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPD
|   .|. |.   |  |. |       | .. ||.|  .    .. . | .| |.  |.  .|... ..    |||.....| || | ..|.| 
nptrdryenlprcditrvkls......ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 782-862 1.6e-11 38.7 In-house 3-85 (199) alignment 
Range on Protein: 782-862
Range on HMM: 3-85/199.0
NQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPD--SDTKDYGPFSVTLSDEQVLTDYTVRKMHVK
 | .||||| |. .|. |||...|.  |  |||. .   . .     |||   | |  || .|||     .  |||.  . . 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 783-862 2.1e-11 38.4 In-house 3-84 (198) alignment 
Range on Protein: 783-862
Range on HMM: 3-84/198.0
QYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPD--SDTKDYGPFSVTLSDEQVLTDYTVRKMHVK
| .||||| |. .|| |||...|.  |  |||. .   . .     |||   | |  || .|||     .  |||.  . . 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 779-868 2.4e-11 37.6 In-house 231-318 (440) alignment 
Range on Protein: 779-868
Range on HMM: 231-318/440.0
DYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEegkMKCQQYWPD-SDTKDYGPFSVTLSDEQVLTDYTVRKMHVKVLEQVT
 ||..  .|||| |.  |..|||||. . | . |.|. .. .     |  |||  . .  .|||.|     . .    || . .|  |.| 
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevh
0048179 (Phosphotyrosine protein) phosphatases II 939-1096 3.2e-11 38.7 In-house 23-130 (144) alignment 
Range on Protein: 939-1096
Range on HMM: 23-130/144.0
KMIDDRNVTAIVMLCQENENDQEVCYqywsngklgeynisllneeihnagyierkievtndnkagdkqqVKQYQITNWDSTGKMTNPQTILLVIEEMYRT
... . ..|... |. | |.. . ..                                           . ||. ..|.  |  . .. .| ..| . . 
ellkklgittvinlteeyepeflere...........................................giqylhlpwpDhgvpdllellleflefieea

QRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQT
..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|..
le..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpn
0043147 (Phosphotyrosine protein) phosphatases II 769-832 4.2e-11 38.4 In-house 5-75 (172) alignment 
Range on Protein: 769-832
Range on HMM: 5-75/172.0
NEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIieegkmkcqQ----------------YWPD
. |||| |.. |    ..|||||| .||| ||||.....   .||..|.          .                .|||
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........lydpellerlgiqylylpwpD
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1005-1096 5.9e-11 36.3 In-house 88-179 (440) alignment 
Range on Protein: 1005-1096
Range on HMM: 88-179/440.0
KQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 . .|||.   |   |       .| .|...  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  |||
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqt
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 695-791 9e-11 35.8 In-house 5-95 (95) alignment 
Range on Protein: 695-791
Range on HMM: 5-95/95.0
IPVDKFGEFVAKGHAKGNEGFRNQFGMLDSgESDHTVTVGLTPSNKLLNRFANIVVYDDNRITLrpmSGHKDctNEYINACYIKDYSNQYQYIATQG
| |  |   | . |.. .. | |.|  .    |  . ||| . .|   ||| ||. ||  |..|   . ..|   .|||||..  |. .  |||.||
ihvsvfhshvlemhsnsdqefdnefksism.tsgapytvgsseanipknrflnifpydatrvvl...ttkrd..sdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 905-1024 1.1e-10 35.9 In-house 12-129 (130) alignment 
Range on Protein: 905-1024
Range on HMM: 12-129/130.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQevcyqYWSNGK-LG--EYNISLLNEEIHNAGYIERK-IEVtNDN
  .|||| |.      . .. .. |. .|. .||||. .| |  .|.|   .|.|.     || . . |   | .| .   . ..  .|. . .|. ...
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikasnlei.esd

KAGDKQQVKQYQITNWDSTGKMTN
    .| .  .||.|| | |   |
lneshqaltmfqisnwpsdgttpn
0048076 (Phosphotyrosine protein) phosphatases II 993-1096 1.1e-10 36.9 In-house 33-128 (145) alignment 
Range on Protein: 993-1096
Range on HMM: 33-128/145.0
KIEVtNDNKAGDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVLKSQRIQKPG
 . .  ... . .... ||. ..|.  |  . ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......|.  | | ||
vlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpg

SVQT
.|..
avpn
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 902-1003 2.3e-10 34.3 In-house 86-189 (349) alignment 
Range on Protein: 902-1003
Range on HMM: 86-189/349.0
KGEHPDYINAVFIN--GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGKLGEYNISLLNEEIHNAGYIERKIEVTND
 |   ||||| ...   .. .| .|    |.  |  .|.|.|   .|  .. | ...|.. | |..|| ...  .... | |   . |.      .| ..
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyianvqGnslrvstv

NKAG
... 
kdtd
subfamily_eak_pd Subfamily eak 745-862 8.7e-10 32.5 In-house 57-173 (332) alignment 
Range on Protein: 745-862
Range on HMM: 57-173/332.0
FANIVVYDDNRITLRPMSGHKDctnEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSD--TKDYGPFS
  .|| || . . | .    ..    ||||  ..      .|| |  .  . .  ||... ...|  ||.. . .|..  | ..|.||      ..| . 
vvkivpydrylvrltssqlnrl...GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VTLSDEQVLTDYTVRKMHVK
|.  .      . .|.. ..
verkefvkrniletrllels
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 743-819 2.6e-09 31.1 In-house 41-120 (347) alignment 
Range on Protein: 743-819
Range on HMM: 41-120/347.0
NRFANIVVYDDNRITLRPMS---GHKDCTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNII
||  .  . |. |. | |     .. | .. |||| .||    . .|| || |. .|. |||...   . . .| | . |
nrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 754-846 3.7e-09 31.0 In-house 8-85 (130) alignment 
Range on Protein: 754-846
Range on HMM: 8-85/130.0
NRITlrpmsghkdcTNEYINACYIKDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEgkmkcQQYWPDSDTKDYGPFSVTLS
.|.            |.|||| ..    .  .|. || |...| .|||... .    ..|..  . ||     ..|||||.  ..    ....
srlq..........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivt
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 862-959 8.4e-09 29.5 In-house 26-121 (303) alignment 
Range on Protein: 862-959
Range on HMM: 26-121/303.0
KVLEQVT-QRPDEVTHNIASQNNDRNRLNQFLPPDNYRVPLKgeHPDYINAVFINGYKEKKAfIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENEND
. .|.|.   | .|..|   .| |.||. . .  |  .| |      || | ...   .||| |... |.  || .||.|| ...|  ...|  ..| |
nefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseyd
0044763 (Phosphotyrosine protein) phosphatases II 751-836 9.5e-09 30.6 In-house 2-76 (178) alignment 
Range on Protein: 751-836
Range on HMM: 2-76/178.0
YDDNRITLRPMSGHKDctNEYINACYIKDYsnqyQYIATQGPvsntlVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTK
.|..|  | ...|.     .||||..| ..     |.....|     .|...|....    ||..|. .| |..|| .|||..   
ldrtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeagi
0051082 (Phosphotyrosine protein) phosphatases II 769-835 1.1e-08 30.3 In-house 3-58 (151) alignment 
Range on Protein: 769-835
Range on HMM: 3-58/151.0
NEYINACYIKDYsnqyqYIATQGPVSntlvDFWRLIWQERSAIIVMITNIIEEGkmKCQQYWPDSDT
. |||. |. ..     .....|| .    ||..|....    ||....  | |  .| .|.|. . 
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelgi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 739-826 1.8e-08 28.3 In-house 34-118 (332) alignment 
Range on Protein: 739-826
Range on HMM: 34-118/332.0
NKLLNRFANIVVYDDNRITLRPMSGHKDctneYINACYIKDYSNQYQYIATQGPVSN-TLVDFWRLIWQERSAIIVMITNIIEEGKMKC
|  .||   . ..| .|. | |  |. |    . || ..  ||..  || .| |. . |   |||.. . . ..|... .| |. | |.
nmdmnriphlycfdhsrvelapqdgkdd....fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 752-885 2.5e-08 28.4 In-house 31-171 (290) alignment 
Range on Protein: 752-885
Range on HMM: 31-171/290.0
DDNRITLRPMsgHKDCTNEYINACYIKdYSNQYQYIATQGPVSN-------TLVDFWRLIWQERSAIIVMITNIIEEGKM----KCQQYWPDSDT--KDY
 ..|. |.     |  ...|| | ... ..|  . |.|| |  .       |. .|| .. ||..  .||. .  |. .      |..| |.|      .
eatrvvLkgy..gkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf

GPFSVTLSDEQVLTDYTVRKMHVKVLEQvtqRPDEVTHNIASQNNDR
. ..|   .     |  .|.. ||  ..   ..  |||.  .. |..
kgltvkCkskekeddvetRelvvkfdde...eeftvtHsllkgWnkl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 879-959 6.4e-08 26.4 In-house 31-114 (332) alignment 
Range on Protein: 879-959
Range on HMM: 31-114/332.0
ASQNNDRNRLNQFLPPDNYRVPLKGE--HPDYINAVFINGYKEKKAFIIAESPMFN-TARNFWKMIDDRNVTAIVMLCQENEND
  .| | ||. ..   |  || |  .  . |. || ...|| .| |.|.|..|. . |   ||.|. .|. . |... . .|..
flnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 914-968 7.3e-08 26.2 In-house 229-280 (440) alignment 
Range on Protein: 914-968
Range on HMM: 229-280/440.0
INGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENEndqEVCYQYWS
..||  |.||| .. |.  |  .||... | ....|.|| | |.     |  || 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywp
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 883-955 1.1e-07 25.7 In-house 49-119 (347) alignment 
Range on Protein: 883-955
Range on HMM: 49-119/347.0
NDRNRLnqFLPPDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQE
.|  |.   | |.. .     .   ||||  |.  . .| .|... |. .| |.||||.   .|| .| . . 
idatrv..vlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
subfamily_eak_pd Subfamily eak 881-1020 1.9e-07 24.8 In-house 51-193 (332) alignment 
Range on Protein: 881-1020
Range on HMM: 51-193/332.0
QNNDRNrLNQFLPPDNYRVPLKGE---HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCQENENDQEVCYQYWSNGK-----L
.. .|| . . .| | | | |      .  ||||  ..  .  . .|..  .  .    ||.|. ...  |||.| .. |.. |   .|. .        
eavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

GEYNISLLNEeIHNAGYIERKIEVTNDNKAgdkQQVKQYQITNWDSTG
| ...   .  .... .  |..|..  |..    .|. |..  |  | 
Gildverkef.vkrniletrllelskGnet...hrvlhykvfGwtett
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 698-778 6.4e-07 23.0 In-house 9-84 (440) alignment 
Range on Protein: 698-778
Range on HMM: 9-84/440.0
DKFGEFVAKghAKGNEGFRNQFGMLDSGESDHTVTVGLtPSNKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYIK
  | ..| .   .    | ... .| || |. .   .| |.||. ||. ||..|| .|. |  . |  |  ..|||| ||.
adfadyvqn..nrrsrafedewsllpsglsqpsdiasl.pnnkvknryrnilaydhsrvmleevkgvpd..sdyinasyin
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 739-824 1.7e-06 21.9 In-house 47-123 (303) alignment 
Range on Protein: 739-824
Range on HMM: 47-123/303.0
NKLLNRFANIVVYDDNRITLrpmsghkdCTNEYINACYIkDYSNQYQYIATQGPVSNTLVDFWRLIWQERSAIIVMITNIIEEGKM
|   |||..... |  .. |        .   || | |. .   . . | || |.| |  |||..| ...   ....    |  |.
nmdknrfvdvicldhskvkl........sdssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydkl
Ig_3 Immunoglobulin domain 583-659 2.4e-06 19.7 Pfam-A 2-75 (75) alignment 
Range on Protein: 583-659
Range on HMM: 2-75/75.0
PPVIEEFPNDMTSEEGrqvlFKVKVKVRGNS-KPSFNWYhNGEPVTDDYAHELRGDGSLLLVS-VEKKHKGTYRFVANN
| .. ......||...     ..   ..|.. .|.. || ...|  ..  . ... .| | .| |  .. |||. ||.|
Pvisvspsptvtsggn....vtLtCsaeggpppptisWy.ietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1003-1065 3.6e-06 21.0 In-house 212-283 (350) alignment 
Range on Protein: 1003-1065
Range on HMM: 212-283/350.0
GDKQQVKQYQITNWDSTGKMTNPQTILLVIE--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAA
 |   | | |. ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....  
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlD
DUF4446 Protein of unknown function (DUF4446) 502-557 4.2e-06 15.6 Pfam-A 3-57 (152) alignment 
Range on Protein: 502-557
Range on HMM: 3-57/152.0
AILSLLLIVIIIVIIIVVVLISKKKRIKKKYNIAIKDSTDKgTATELGVSSYSTYD
.|. .||.......|...||. | ...||||.  .. ...| .  || .. .. ..
liiiallvlvvvllillivllvklsklkkkyrklmrgkdgk.sleelleeeleeie
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 786-861 4.9e-06 20.8 In-house 39-105 (255) alignment 
Range on Protein: 786-861
Range on HMM: 39-105/255.0
YiatqgpvsnTLVDFWRLIWQERSAIIVMITNIIEEGKMKCQQYWPDSDTKDYGPFSVTLSDEQVLTDYTVRKMHV
          |.  |.. | | ..  .||...  |||. ||..|.|    .      |...  .  .|  .| ...
l.........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtlei
OppC_N N-terminal TM domain of oligopeptide transport permease C 502-528 7.2e-06 11.9 Pfam-A 18-42 (56) alignment 
Range on Protein: 502-528
Range on HMM: 18-42/56.0
AILSLLLIVIIIVIIIVVVLISKKkrI
|...| .....|...|.. |.|.    
AvvgliillllillaifaPllspy..d
Ig_2 Immunoglobulin domain 609-672 7.8e-06 17.8 Pfam-A 23-80 (80) alignment 
Range on Protein: 609-672
Range on HMM: 23-80/80.0
VRGNSKPSFNWYHNGEPVTDDYAHelrgdgsLLLVSVEKKHKGTYRFVANND-AGTVSQQVVLTV
..|| .|.. ||..||...   .        |.. .|. ...|||. .| |.  ...|. | .||
apgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsvevtv
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 880-927 8.3e-06 19.9 In-house 46-94 (95) alignment 
Range on Protein: 880-927
Range on HMM: 46-94/95.0
SQNNDRNRLNQFLPPDNYRVPLKGE-HPDYINAVFINGYKEKKAFIIAE
  |  .||. . .| |  || |      |||||.|..||  |...| |.
eanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq