Gene PTPRD-11 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP064_AA protein Get Run
AqueP064_AA_940-1217 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 943-1225 5.5e-160 525.9 In-house 7-287 (287) alignment 
Range on Protein: 943-1225
Range on HMM: 7-287/287.0
FNRMSKLDTKTGQTGYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
|..... ....|..|...|||||.|||||.|||||||||||.||||.||.|.|.||||.||.|||||||||||.||||||||||||||||||||||||.|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkli

DDRNVTAIVMLCHENENDEEVCYQYWPSTSSgLIVGEYNIALLNEEiISNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYR
||||||||||||.|.||||||||||||...| ...|||||.||||| ...|.||||.|.|..||..||||||||||||||||||.|.||||||||||||.
ddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk

TQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFETYANF
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..||..|..|||.||||||||..|
tqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 948-1222 9.4e-126 413.5 In-house 12-289 (290) alignment 
Range on Protein: 948-1222
Range on HMM: 12-289/290.0
KLDTKTGQTGYEEQFTVLQQvTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLK--NEHPD----YINAVFINGYKEKKAFIIAESPMFNTARNFWKM
  ....|..|...||..|.. .... .||....|.|. .||..........|..|.  ..|.|    ||||..|.||||||..|....|..||...|||.
anghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

IDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLiVGEYNIALLNEEIISnGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMY
|....||.||||....|.....|.||||....   .||..| |||||... . ||||.|.|..|.. .||.|.||||||||||||.||||||||||||||
iwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemy

RTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFETY
.||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||| ||||||||||| ||||||||
ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 953-1221 1.7e-71 235.9 In-house 19-288 (305) alignment 
Range on Protein: 953-1221
Range on HMM: 19-288/305.0
TGQTGYEEQFTVLQQVtQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEHP--DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
. ..|.|.|.  |..  . . .|... |........... |... ...  |....  ||||| ...|||.||..|.| .|. || ..||..| .  |. |
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLCHENENDEEVCYQYWPSTSSG-LIVGEYNIALLNEEIiSNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGN
|||..  |.... |.|||| . .     ||... | .|.   .. ||||...   .. .....| |||.|.|   |  . . ..| .|... ..|.|  .
vmltklveggkdkCrqYWpesktekkefgefsvelksekt.asdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFET
....||||..|||. .|.|    ....|.|.|.|||.|||  | .... ||| .||. .....  .. ...|
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 930-1223 1.2e-70 233.1 In-house 1-297 (298) alignment 
Range on Protein: 930-1223
Range on HMM: 1-297/298.0
GNTQVDSRNARIVFNRMSKLDTKTGQTGYEEQFTVLQQVTQRPDEVTHNIA--SQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEKKA
|||...... .. ...... . |.. |||...|  |..|... .| ....|  ..|..||| .. .. .  || |..    |. |||||.|...||...|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGlIVGEYNIALLNEEIISNgCIERKFELKHTNKTsDKQQVKQYQITNWDS
||... |. .|  .||.|. ......||||   .| |.  . .|||.. .    || .. ||..|  ..  | ||......... ....|.| . |.| .
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefad.livrklkvskkkee.kerevrqlhftsWpd

TGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFETYA
 |  .| ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| .||  |...|| .||||....
kgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0050432 (Phosphotyrosine protein) phosphatases II 916-1224 1.4e-70 233.4 In-house 1-307 (308) alignment 
Range on Protein: 916-1224
Range on HMM: 1-307/308.0
YIFVNDAVLESVTCGNTQVDSRNARIVFNRMSK-LDTKTGQTGYEEQFTVLQQVTQrPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLkNEHPDYINAVF
|... ||.|| .....|..   . ..    . | |. ... ...||.|  |..|.  . | ..    .| ||||.. .||  . || | .|. ||||| .
yllildallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsy

INGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPST--SSGLIVGEYNIALLNEEIiSNGCIERKFELKHTNKTsDK
..||  | ...||.. .|. ||  .||.|. . ||. ||||. . ||. | |.||||..  .. |..| . . ||.||.  .... |..||.....  . 
vdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdg.es

QQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQ
 .|.... |||   |  ..|. .|  .|.. ...   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.||| .||. ...
rtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

IVLVYLDSFETYAN
..| || ...|..|
alleylklkltkln
0051299 (Phosphotyrosine protein) phosphatases II 947-1216 4.6e-68 225.1 In-house 18-286 (288) alignment 
Range on Protein: 947-1216
Range on HMM: 18-286/288.0
SkldtKTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
     ..|.||..|.|  |....    .... .  .| .|||.. .|| .. || |..    |. ||||| .|.||. |..||... |. ||  .||.|.
l....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmv

DDRNVTAIVMLCHENENDEEVCYQYWPStSSGLIVGEYNIALLNEEIiSNGCIERKFELKHTN---KTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEE
 . ||. ||||. . |.. | |.||||. .. |..|.. . ||.||.  .... |..|.....   ... ...|.... |||   |  ..|. .|  ...
weqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

MYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
... ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.||| .||. .....| ||
vrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 959-1224 6.8e-68 224.4 In-house 3-282 (284) alignment 
Range on Protein: 959-1224
Range on HMM: 3-282/284.0
EEQFTVLQQVTQRPD-EVTHNIASQNNDKNRSTQFLPPNNYRVPLKN-----EHPDYINAVFINGY-----KEKKAFIIAESPMFNTARNFWKMIDDRNV
||.|  |...|  .  .... .. .| .|||....|| .. || ||.     |. ||||| ...||     . ||.||..  |. ||  .||.|. . ||
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

TAIVMLCHENENDEEVCYQYWPSTSSGLIVGEYNIALLNEEIiSNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK-
. ||||. . ||. | |.||||.... |. |.. . ||.||.  .... |..||.... |.   .|.....|.|   |  ..|. .|  .... . ... 
rvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFETYAN
 |.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.||| .||. .....| || .. |...
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
0036941 (Phosphotyrosine protein) phosphatases II 948-1221 8.3e-67 220.9 In-house 5-282 (297) alignment 
Range on Protein: 948-1221
Range on HMM: 5-282/297.0
KLDTKTGQTGYEEQFTVLQQVTQrPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
.|. ... ......|  |...   . . .. .  .| .|||.. .|| .. || |..|. ||||| ...||. |..||... |. ||  .||.|. . ||
llekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

TAIVMLCHENENDEEVCYQYWPST-SSGLIVGEYNIALLNEEII-SNGCIERKFELKHTnKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQR
| ||||. . |.. | |.||||..  . | .|.. . ||..|.. ..... |..|...| ..... .|.....|.|.  |  ..|...|  ||.. . ..
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

KR-GNTSIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFET
.  ... ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.||| .||. . ...| .| ...|
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0047943 (Phosphotyrosine protein) phosphatases II 948-1216 9.4e-67 220.7 In-house 4-272 (273) alignment 
Range on Protein: 948-1216
Range on HMM: 4-272/273.0
KLDTKTGQTGYEEQFTVLQQVTQrPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
.|....| |...|.|  |....  . . .. .  .| ||||.. .|| .. || |.... ||||| ...||. |..||... |. ||  .||.|. . ||
llekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

TAIVMLCHENENDEEVCYQYWPSTSS--GLIVGEYNIALLNEEIiSNGCIERKFELKHTNKTSdKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQR
. ||||. . |.. | |.||||..     |..|.. . ||.||.  .... |..||....    . .|.... |.|   |  .... .|  ||.. ....
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkale

KR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
.  .|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.||| .||. . ...| ||
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 943-1216 2.3e-65 216.7 In-house 14-304 (307) alignment 
Range on Protein: 943-1216
Range on HMM: 14-304/307.0
FNRMSKLDTKTGQTGYEEQFTVLQQVTQR-PDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKN-----EHPDYINAVFI--------NGYKEKKAFIIAE
.  . .|..... ||....|  |..|| . ..| ..    .| ||||.. .|| .. || |..     |. ||||| ..        .||. |..||.. 
llllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatq

SPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLIVGEYNIALLNEEIiSNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMT
.|. .|  .||.|. . .||.||||... |.. | |.||||.... |  |.. . ||.||.  .|.. |..|......|.   .|.... |.|  .|  .
gPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

NPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
.....|  |||. . ...  ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||. .||. . ...| .|
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 952-1224 6.1e-65 213.9 In-house 11-301 (301) alignment 
Range on Protein: 952-1224
Range on HMM: 11-301/301.0
KTGQTGYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
.. ....|||.. |....... .|... . .. ....... .. |.  .  |.     . .|||| .|.||.|||.||.|..|| .| ..||..| .  .
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TAIVMLCHENENDEEVCYQYWPSTS-SGLIVGEYNIALLNEE----------------IISNGCIERKFELKHTNktsDKQQVKQYQITNWDSTGKMTNP
..|||.. ..|. .. |.||||... .   .|. .. | ||                   .|| |||||. |...   . ..| |.|.|.|   | . .|
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvrep

QTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFETYAN
.|.| ||...  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.|..||  |....  ||   .||||
rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
0040438 (Phosphotyrosine protein) phosphatases II 955-1221 1.9e-64 213.3 In-house 17-281 (317) alignment 
Range on Protein: 955-1221
Range on HMM: 17-281/317.0
QTGYEEQFTVLQQVtqRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
 |. .|.|  |...   .|. .. .  .| ||||.. .||  . || |...      ||||| ...|...|..||.. .|. ||  .||.|. . .|| |
ftalleefedllsl..kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

VMLCHENENDEEVCYQYWPStSSGLIVGEYNIALLNEEIiSNGCIERKFELKHTnKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNT
|||... |.. | |.||||.  . | .|.. . ||.||   .|.. |..|.... ..|.. .|.... |.|.  |   .|...|  .|.. . .. ....
vmLteleelgrekcaqYwpl.getltygdftvtllseee.lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpgg

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFET
 ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| .||. . ...| ||  ..|
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
subfamily_PTPRD_pd Subfamily PTPRD 980-1223 1.9e-64 213.3 In-house 45-288 (564) alignment 
Range on Protein: 980-1223
Range on HMM: 45-288/564.0
ASQNNDKNRSTQFLPPNNYRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSsGL
...|  |||  . .. .. || |.    .|  ||||| ||.||...||.| .  |. .| ..||.|. ..|.. |||| . .|.... | .|||...   
kpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.te

IVGEYNIALLNEEIISNGCIeRKFELkHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINK
 .||. . | .|| ... .| |.|.| ...|.|....|.|.. |.| ..| .......| .|... ... ....  ||||||  |||. .|..    ...
tygeltVtleeeeeladyei.rtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamler

CKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFETYA
 |.|...|..|..|  | |..  ||| .||. |....| .|....|  
ikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntev
DSPc_SM00195 959-1216 2.6e-64 212.4 In-house 3-262 (263) alignment 
Range on Protein: 959-1216
Range on HMM: 3-262/263.0
EEQFTVLQQVTQRPdEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
.|.|. |.. |.   |.|... ..|..|||....|| .. || ||.|.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

HENENDEEVCYQYWPSTS-SGLIVGEYNIALLNEEIISNGCIERKFELKHTNKtSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRgNTSIV
 |.||..| |..|||..| .   .|.... | ..|. .. .| |..||....| .....|.|||..||   |   ... .| ...... ....  .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
||||. |||...|... . ..|...|  .|.|...|. | |.||.||| .||. | ...| |.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 959-1216 2.6e-64 212.4 In-house 3-262 (263) alignment 
Range on Protein: 959-1216
Range on HMM: 3-262/263.0
EEQFTVLQQVTQRPdEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
.|.|. |.. |.   |.|... ..|..|||....|| .. || ||.|.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

HENENDEEVCYQYWPSTS-SGLIVGEYNIALLNEEIISNGCIERKFELKHTNKtSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRgNTSIV
 |.||..| |..|||..| .   .|.... | ..|. .. .| |..||....| .....|.|||..||   |   ... .| ...... ....  .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
||||. |||...|... . ..|...|  .|.|...|. | |.||.||| .||. | ...| |.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0039614 (Phosphotyrosine protein) phosphatases II 944-1220 2.2e-62 206.5 In-house 20-293 (297) alignment 
Range on Protein: 944-1220
Range on HMM: 20-293/297.0
NRMSKLDTKTGQTGYEEQFTVLQQVTQrpDeVTHNIASQNNDKNRSTQFLPPNNYRVPLKN-----EHPDYINAVFINGYKE-KKAFIIAESPMFNTARN
... .|..... |.....|  |....   |  ..    .| ||||.. .|| .. || ||      .. ||||| ...||.  ...||..  |. .|  .
dlllllekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetved

FWKMIDDRNVTAIVMLCHENENDEeVCYQYWPSTSSglIVGEYNIALLNEEIiSNGCIERKFELKHtN-KTsdkQQVKQYQITNWDSTGKMTNPQTILLV
||.|. . .||.||||. ..|..   |.||||....    |.. . ||..|   .|.. |..|... | ..    .|...| |.|   |   .....| .
FwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.ldgytvrtlevtn.nges...rtvthfqytgwpdhgvppslelllef

IEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFE
.|.. . ...  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| .||. .....| .|  . 
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
Y_phosphatase Protein-tyrosine phosphatase 983-1213 8.3e-62 204.0 Pfam-A 1-234 (235) alignment 
Range on Protein: 983-1213
Range on HMM: 1-234/235.0
NNDKNRSTQFLPPNNYRVPL--KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWP-STSSGLIVGE
| .|||....|| .. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....|...| | |||| ...  |  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YNIALL-NEEIISNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
... |  .|. ...... ||.|||.... |.|..|||...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
|. .||.|..|. | |.||.||...||. . ...|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 983-1213 8.3e-62 204.0 In-house 1-234 (235) alignment 
Range on Protein: 983-1213
Range on HMM: 1-234/235.0
NNDKNRSTQFLPPNNYRVPL--KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWP-STSSGLIVGE
| .|||....|| .. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....|...| | |||| ...  |  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YNIALL-NEEIISNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
... |  .|. ...... ||.|||.... |.|..|||...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
|. .||.|..|. | |.||.||...||. . ...|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 953-1224 2.4e-61 202.5 In-house 17-288 (318) alignment 
Range on Protein: 953-1224
Range on HMM: 17-288/318.0
TGQTGYEEQFTVLQQVTQRPDEvTHNIASQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
.|.. ..|..  |..... . . .. . . |. ||| .  |. .. || |..    |  ||||| .|.||..|||.| | .|. .| ..||.|. ..| .
sGelllseeyerlsrseetvts.lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa

AIVMLCHENENDEEVCYQYWPSTSSGLiVGEYNIALlNEEIISNGCIERKFELKHtNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRG
 |||| .|.|.  . . .||||  |    |.  . | .||. ..  . |.|.... .......||.||..|.|  .|  ... ..| .. .  ..|.| |
vivmltqeeergkakvhryWPskgsrs.ygklvvel.keevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFETYAN
.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  ||| .||. |....| .| |..|...
agpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 955-1213 8.5e-61 200.3 In-house 5-263 (283) alignment 
Range on Protein: 955-1213
Range on HMM: 5-263/283.0
QTGYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEHPDYINAVFIN---GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIV
..... .. ||....  . ... . |..|. |||  . .| ...|| ||.| .||||||||     ||..| .||| ||. .| ..||||. |...||||
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLCHENENDEEVCYQYWPSTSSgLIVGEYNIALlNEEIISNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTiLLVIEEMYRTQRKRGNTS
|| .  |. .. | ||||.  |    ||. ..| ..|  ||  | ... |.. . . ..  .  ||. .| . |. .   . |. .. .   |..  .. 
mltklqedlrikCsqyWPkrGs.edyGeftvtl.rkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiins.lvkfnkvislqteskkgP

IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
|||||| ..||.|.|.||...... .|| |.|||.|.|  | |... ||| .||. . ..||
ivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
0043336 (Phosphotyrosine protein) phosphatases II 952-1216 3.3e-60 199.3 In-house 16-277 (278) alignment 
Range on Protein: 952-1216
Range on HMM: 16-277/278.0
KTGQTGYEEQFTVLQQVTQrpDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
....|.....|  |....   |. .. .  .| ||||.. .|| .. || |...      ||||| ...||. ...||..  |. .|  .||.|. . .|
lnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

TAIVMLCHENENDEEVCYQYWPstSSGLIVGEYNIALLNEEIiSNGCIERKFELKHtNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkR
| ||||. . |.. . |.||||  .. | .|.. . ||.||   .... |..|... .... ...| .|. ..|   |  ......|  .... . ..  
ttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.d

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
 |. ..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.||| .||. .....| ||
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 981-1224 2.8e-58 192.1 In-house 7-250 (250) alignment 
Range on Protein: 981-1224
Range on HMM: 7-250/250.0
SQNNDKNRSTQFLPPNNYRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEvCYQYWPSTSSgLI
 ||..||| ..... .. || |..|.     |||||.|..||.|.||||.. .|. .|  .||.|. ......||||   .|.... . ||||   .  .
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka.ek

VGEYNIALLNEEIISNgCIERKFELKHTnKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKC
 |.  . ||..|. ..  . ||. | .. | .|...|.|.. ..|   |   . ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... 
yGdvtvsllskeefad.ytkrklklska.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

KTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFETYAN
|.| |.|||.|.|  |...|..|.. .||  ...|.| .|||.| ||.
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
0045098 (Phosphotyrosine protein) phosphatases II 966-1217 1.3e-57 190.6 In-house 16-273 (278) alignment 
Range on Protein: 966-1217
Range on HMM: 16-273/278.0
QQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPlknehpDYINAVFINGYkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCY
. ..  |.|.|...   | |||| ...|| .. ||       ||||| .|.||  .|.||..  |. .|. .||.|. . ..|.||||... |.. | |.
llllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

QYWPStSSGLIVGEYNIALLNEEIIsNGCIERKFELKHT---NKTSDKQQVKQYQITNWDSTGKMTNP--QTILLVIEEMYRTQR------------KRG
||||. .. |. |.. . ||.||.. .  . |.... ..    ..  .  |.......|.  |  ..|  . .| ..|.. . ..              .
qywpe.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

NTSIVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTIQQYQGIFQIVLVYLD
.. ..||||  |||.....|| . .  .  ||..|.....|  | |.|| .||. .||. ... .| .| 
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 949-1221 2.7e-57 189.3 In-house 17-288 (319) alignment 
Range on Protein: 949-1221
Range on HMM: 17-288/319.0
LDTkTGQTGYEEQFTVLQQVTQRpdEVTHNIASQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDD
|.. ||.|. |..|  |.. ..   ....    .|..||| .. |. .. || |..    |  ||||| ||.||.|...|| . .|. ||  .||.|. .
las.tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWe

RNVTAIVMLCHENENDEEVCYQYWPSTSSgLIVGEYNIALLNEEIiSNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQ
...  .|||.. .|. .  . .|||..      |.. . |..||   .. | ||..|.. .   .  .||..| |.|   .  .. ...| ..... ...
eessivvmltklveklkvklkkywpeenf.eeyGrlivtleeeee.ledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksr

RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFET
.|  .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||. .||. |....| ......|
ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
0040439 (Phosphotyrosine protein) phosphatases II 975-1216 3e-56 186.1 In-house 3-246 (249) alignment 
Range on Protein: 975-1216
Range on HMM: 3-246/249.0
VTHNIASQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPS
... .   | ||||.. .||... || |.     .. ||||| .|.||. |..||..  |. .|  .||.|. . ..|.||||... |.. | |.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

tSSGLIVGEYNIALLNEEIiSNGCIERKFELKHTnKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAA
 .. | .|.. . ||..|. ..... |..||... ..... .|...|.|.|  .|   .....|  ||..   ...   .. ..||||. |||...|.||
.ggsleygdftvtllsvev.kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

ATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
 . ..  ..|. .|.....|  | |.||.||. .||. . ...| .|
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 980-1216 1.4e-55 183.7 In-house 6-243 (245) alignment 
Range on Protein: 980-1216
Range on HMM: 6-243/245.0
ASQNNDKNRSTQFLPPNNYRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPStSSGL
   | ||||....|| .. || |...      ||||| ...||. .. ||..  |. .|  .||.|. . ..|.||||. | |.. . |.||||. .. |
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

IVGEYNIALLNEEIiSNGCIERKFELKHtNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINK
 .|.. . ||.||.  .... |..|... .... ...| .|. ..|.  |  ......| ..|.. . ... .|. ..||||. |||...|.|| . .. 
tygdftvtllseeh.lddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

CKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
 ..|. .......|  | |.||.||| .||. . ...| .|
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPRA_pd Subfamily PTPRA 981-1215 3.4e-54 178.9 In-house 56-294 (330) alignment 
Range on Protein: 981-1215
Range on HMM: 56-294/330.0
SQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSgLI
 .|..|||  . || .  || | .    |. ||||| ||.|||||. || |  |  .|  .||.|| ... ..|||| . .| .|| |.||||.  . . 
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vt

VGEYNIALLNEEIISNGCIeRKFELKHT-NK--TSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTI
 |. .... .|... .  . ||| ...  ..    ....|.|.  | |   |  ..|. .| ..... ..... .. .||||||  |||.  |..  . .
yGnirvevedetvlvdytv.rkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavl

NKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVY
.. |.|...|||...|. | |.|  ||| .||. |....| |
ervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRG_pd Subfamily PTPRG 953-1221 1.4e-52 173.7 In-house 16-292 (563) alignment 
Range on Protein: 953-1221
Range on HMM: 16-292/563.0
TGQTGYEEQFT-VLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKN-----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 |..|..|.|  . ......  ...|  . .|  ||| .. .. .. || |..     .. ||||| .|.||. .||||..  |. .|.  ||.|| ..|
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

VTAIVMLCHENENDEEVCYQYWPStSSGLIVGEYNIALLNEEIISNGCiERKFELKHTN-----KTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMY
|. |||.   .|.  . | .|||.    . .|. .. | .||...    .|.. .|...     .. ....|.||. |.|  .|  . .   |  ..   
vaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalyt.vrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkss

RTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFET
.....     ||||||  |||. ....  | ... ..| ...||..||  | |..  |||. ||. .....|  . | ||
aanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_Ptp69D_pd Subfamily Ptp69D 949-1218 1.8e-50 166.8 In-house 13-288 (307) alignment 
Range on Protein: 949-1218
Range on HMM: 13-288/307.0
LDTKTGQT--GYEEQFTVLQQVtQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
| .. ..|  |... .  |..  . . . .      |. |||. .  . ...|| ||    .|. ||||| ||.|||||| ||.|  |. .|. .||.||
lksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmi

DDRNVTAIVMLCHENENDEEVCYQYWPSTsSGLIVGEYNIALLNEEIISNgCIERKFELKHTNKTS----DKQQVKQYQITNWDSTGKMTNPQTILLVIE
 . .|| ||||  ..| ... | .|||        |. .. | .||  |.  |.|.... .....|    |...| ||. |.|. .     ....| .||
aeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsd.yiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklie

EMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDS
...  ...  .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  || ..||. ... .| | . 
qvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 951-1221 1.8e-50 166.6 In-house 16-286 (288) alignment 
Range on Protein: 951-1221
Range on HMM: 16-286/288.0
TKTGQTGYEEQFTVLQQVTqRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 ....||..|.. .| ..  . ..||    ..|..|||  . || .  || ||.    .  ||||| .|.|.|.||..| . .|. .|  .||... ...
sarnrtgfseeynsLaale.ktksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

VTAIVMLCHENENDEEVCYQYWPSTSSGLIVGEYNIALLNEEIISNgCIERKFELKhtnKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK
.. |||| .  |.... | .|||..      |. .. |....   .  ..||..|.   |. .. ...||| . |  .|   . . .| ... .  .. .
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeled.fvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqa

RgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL--VYLDSFET
     |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  ||| .||. |....|  .. |. ..
d.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgvae
0037934 (Phosphotyrosine protein) phosphatases II 980-1215 9.1e-50 164.8 In-house 7-241 (243) alignment 
Range on Protein: 980-1215
Range on HMM: 7-241/243.0
ASQNNDKNRSTQFLPPNNYRVPLKNehPDYINAVFINGYKeKkaFIIAESPMFNTARN----FWKMIDDRNVTAIVMLCHENENDEEVCYQYWPstSSGl
  .| .||| . .|| .. || |..   ||||| .|.... .  .|.   |. .|  .    ||.|. . ..|.||||... |.. | |.||||  ..  
lpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.

IVGEYNIALLNEEIISNgCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCA
  |.. . ||.||  .. .. |...|.... .  ...| .|. ..|   |  ..|. .|  ..|..  ...        ..  ..||||  |||.....|
tygdftvtllseehldd.ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

AATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTIQQYQGIFQIVLVY
| . . ..   | .|.....|  | |.|| .||| .||. . ...| .
aylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 951-1218 2.8e-49 162.8 In-house 10-278 (281) alignment 
Range on Protein: 951-1218
Range on HMM: 10-278/281.0
TKTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNYRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
..  ..|. |... |... .. .  |   | .|  ||| .     .. || .    .|.. ||||| |..|||..|..|....|. ..  .||.|. ...
sqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

VTAIVMLCHENENDEEVCYQYWPSTSSGLIVGEYNIALLNEEIiSNGCIERKFELkhTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK
|.||||. .| |..   |..|||  .| |..|.. .  ..||  ..  |||||.|  .........|.| . |.|  .|  .... .|   .|......|
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaeee.katyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltek

RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDS
. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||. ||. ....|| .|| 
ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN12_pd Subfamily PTPN12 951-1215 6.1e-49 161.4 In-house 3-276 (290) alignment 
Range on Protein: 951-1215
Range on HMM: 3-276/290.0
TKTGQTGYEEQFTVLQQVTQRP--DE---VTHNIASQNNDKNRSTQFLPPNNYRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKM
 |.|.  ....|. |......   ..    ..  ...|  |||    || .. || |.    .|. ||||| ||.| ..|...| | .|. .|  .||.|
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

IDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLI-VGEYNIALLNEEIISNGCIERKFELKHTnktSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEM
|.. ||. .||.|.| |..   | .|||..    . .||... | .|. .... . | .....    .....|.|.. |.|   |  ......| .||..
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielv

YRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVY
 ..|. . .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  ||| .||. ... |. .
relqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_PTPRB_pd Subfamily PTPRB 950-1217 1.1e-48 160.8 In-house 19-286 (293) alignment 
Range on Protein: 950-1217
Range on HMM: 19-286/293.0
DTKTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNYRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDR
 ..  .... |..  |..| .   .|. . ...|..||| |. || .. || |    .... ||||| .|.||. .. || .  |. .|  .||.|. ..
mkadsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwek

NVTAIVMLCHENENDEEVCYQYWPSTSSGLIVGEYNIALLNEEIISNgCIERKFELKHtnkTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQ-
....|||| .  |.  . | .|||....  . |. .. |..||  ..  . |......   ......|.||. | |   |   ...|.|  .... ... 
kssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeled.wvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaie

RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLD
..  .. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   ||| .||  | | || .| 
ktaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPRK_pd Subfamily PTPRK 981-1213 1.7e-48 160.0 In-house 41-274 (314) alignment 
Range on Protein: 981-1213
Range on HMM: 41-274/314.0
SQNNDKNRSTQFLPPNNYRVPLKN---E-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGli
 .|..||||.. |.... || |.    . . ||||| .|..||  .|||..  |. .| ..||... | | ..|||| .  |.    |..|||  ..   
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..

VGEYNIALLNEEIISnGCIERKFELKH-TNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINK
 |. .. |.. |. .   . | | ... . . .....|.|.| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||. .|.| .. .. 
ygdikvelvetella.elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldm

CKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
 ..|||.|||.. |. | .|.  |.| .||. |....|
ieregvvdvfnavktlrsrkvnmveteeqykfiydvil
subfamily_PTPN23_pd Subfamily PTPN23 952-1216 2.5e-47 156.1 In-house 11-280 (288) alignment 
Range on Protein: 952-1216
Range on HMM: 11-280/288.0
KTGQTGYEEQFTVLQQVTQRP-DEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEHPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTA
  |.|. ...|  |.|  ..   . .  ||  . .||||.  || .. || |.... ||||| |...       ||.. .|. .|.  ||.|. .. .  
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLCHENENDEEVCYQYWPSTS-SGLIVGEYNIALLNEEiISNGCIERKFELKHTnKTSDKQQVKQYQITNWDSTGKMTNPQTILLVI---EEMYRTQR
|||| ...| ... . .|||.        |.....| ...  .. ..||...|..  ... ...|.  |.|.| . |    |.|.| ..   |..|....
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr.etethvervlkletl.dadavksvshlqltsWpelGvPasPetllqfldevesayeavq

KRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
.. .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||. .|..  ...|| . 
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 979-1217 1.8e-46 153.4 In-house 40-278 (315) alignment 
Range on Protein: 979-1217
Range on HMM: 40-278/315.0
IASQNNDKNRSTQFLPPNNYRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPS-TSS
  ..|  |||    || .. || |    .. . ||||| .|..... ||.| .  |   .  .||.|. . .||.|||. . .|.|   | ||||   . 
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

GLIVGEYNIALLNEEIISnGCIERKFelkHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTI
    |.....||. |  . . . ||.    | |. ....| |.| |.|   |   .  ..| .| |.    ... . |..||||  |||. .....   .
svefGsikvellsleadt.dgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevv

NKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLD
.. | . ..|||...|  | ..|  ||| ..|  |...|| .| 
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN6_pd Subfamily PTPN6 944-1218 3.4e-46 152.6 In-house 14-299 (306) alignment 
Range on Protein: 944-1218
Range on HMM: 14-299/306.0
NRMSKLDTKTGQTGYEEQFTVLQQVTQ-RPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNE---HPDYINAVFINGY--KEKKAFIIAESPMFNTARN
....| .......|.||.|  |||  . .  . ..    .|. |||    || .. || ||..     ||||| .|..   ...|..| ..  . .|  .
selekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsd

FWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLIVGEYNIALLNEEIIsNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVI
||.|. . | . |||. .|.|  .| |..|||....    |....  ..|.   .  | |.. .....| .....| ||. ..|   |  ..|...|  .
FWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksl.adYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfl

EEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDS
|.. | |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | ||| |||. .....  |...
edvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 947-1213 3.4e-46 153.0 In-house 25-288 (319) alignment 
Range on Protein: 947-1213
Range on HMM: 25-288/319.0
SKLDTKTGQTGYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
 | | .  .| .| .|  . ...    . |.    || |||| .. |. .. .| |..    |  ||||| |..||. |. .| |  |. ||  .||.||
nksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmi

DDRNVTAIVMLChenendEEVCYQYWPSTSSgLIVGEYNIALLNEEIiSNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEE-MY
 . |...||.|       .. | ||||        ..... .   |  ..  . |..|| .  |  |.....|. .  |   |.   |  .. ...   .
weyncstivllt......kdkcsqywplkiv.ikeerfkvkvdsvee.taeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrh

RTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
 |........||||||  |||. .. .  . ... | |  .||.....  | |..  || . ||. |.  .|
ltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 974-1213 1.3e-45 151.0 In-house 16-252 (284) alignment 
Range on Protein: 974-1213
Range on HMM: 16-252/284.0
EVTHNIASQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenendEEVCYQYWP
. |.    || |||| .. |. .. .| |..    |  ||||| ||.||. |. .| .  |. ||  .||.|| . |...||.|       .. | ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

STSSgLIVGEYNIALLNEEIiSNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCA
        ..... .   |  |.  . |..|| .  |  |.....|. .  |   |.   |  .. ...   . |........||||||  |||. .. .
lkiv.ikeerfkvkvdsvee.seeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
  . ... | |  .||.....  | |..  || . ||. |.  .|
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 962-1221 1.8e-45 150.4 In-house 32-289 (297) alignment 
Range on Protein: 962-1221
Range on HMM: 32-289/297.0
FTVLQQVTQRPDEVTHNiaSQNNDKNRSTQFLPPNNYRVPLK--NEH--PDYINAVFINGYKEkkAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEN
|  | . . .|. |...    | .|.| .  || .  || |.  |..   ||.|| |..|.|.   .|  . || .|  .||.|. | .|..|||| ..|
flclpeaniqpqtvaek..kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddn

ENDEeVCYQYWPSTSSGLiVGEYNIALLNEEIiSNGCIERKFELKHtNKTSDKQQVKQYQITNWDSTGKMT--NPQTILLVIEEMYRTQRKRGNTSIVVH
|.|.  | .||. ...    |.  . ||  .   .| |.|..|... .|.  .. ||||| ..| .       . ...| .|.|.  .  .. .. ..||
erdk.kcaryWsdkgvtt.fGdvsvvllsvse.reGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvh

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSFET
|.  ||| .....    . . | |  .|.|...|  | ..|  ||| .||. ....|| .| | .|
claGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 951-1217 3.4e-45 149.1 In-house 12-277 (515) alignment 
Range on Protein: 951-1217
Range on HMM: 12-277/515.0
TKTGQT-GYEEQFTVLQQVTQRPDEVTHNiaSQNNDKNRSTQFLPPNNYRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDR
.| ..|  . |.|  |      |. |. .    |  |||    || .. || |     | | ||.|| .|....  ||.| .  |   .  .||... . 
nknrhttlfseefhdlpgpniypqtvaqe..einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqe

NVTAIVMLCHENENDEEVCYQYWPS-TSSGLIVGEYNIALLNEEIISnGCIERKFELKhtnKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMyRTQ
|||.|.|. . .|.|   | .|||   .  .  |.... |.  |  . | | ||...    | .| . | |.. |.|   |   . ...| .| |. ...
nvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleact.ggikrkltvl...kgddsrtvtqfhfteWPdkGvpkhtssllklikev.kad

RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLD
. . . ....|||  |||  .....   . . ||  ..|||....  | ..|  ||| .||  |...|| .| 
hgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 981-1217 2.9e-44 146.2 In-house 26-269 (274) alignment 
Range on Protein: 981-1217
Range on HMM: 26-269/274.0
SQNNDKNRSTQFLPPNNYRVPLKN-----EHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSG
. .. ||| .. || .| || |..     |  .|||| .| ||.| .||.. .  |. ||  .||.||  ..|. |||| . .|..|. | .|.| . . 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

LIVGEY-NIALLNEEII-SNGCIERKFELKHTNKtsdKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAA
 | ..| .. . .|.|.  |.   ||. ||....   ...|| |  |.|  .    ...|.| ...|. ...... .   ..|||||  .||  .| |. 
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLD
 .... . |.|.||...    |... | ||| .||. |....  || 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 955-1213 1.5e-43 143.9 In-house 23-276 (315) alignment 
Range on Protein: 955-1213
Range on HMM: 23-276/315.0
QTGYEEQFTVLQQVTQRPDEVTHNIasQNNDKNRSTQFLPPNNYRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
. |.....  .     .| .|...|  .| .|||  . .. .. || |    ...| ||.|| ||.||. |. .| |..|  .. ..||... . ... |
kngfkqdyesipggqlhpldvakki..enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigki

VMLCHENENDEEVCYQYWPSTssGLIVGEYNIALLNEEIISNGCIeRKFelkHTNKTSDKQQVKQYQITNWDsTGKMTNPQTILLVIEEMYRTQRKRGNT
|||    |.... . .|||     .| |.. ... .||. .. .. | .    .   .. ..| |...| |  . ....  . |. .    .  ..   .
vmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytv.rtl...svvfgdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvg

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
.||||||. |||.  |..  . ... ..| .|||.....  | .. . ||...||| |....|
aivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 953-1216 3.6e-43 142.9 In-house 20-288 (325) alignment 
Range on Protein: 953-1216
Range on HMM: 20-288/325.0
TGQTGYEEQFTVLQQVTQRPDevTHNIASQNNDKNRSTQFLPPNNYRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNvT
  | |.  .| .|  .       .     .| .|||    .. .. || |.    . . ||||| ... .|.|. |. | .|. .|  ..|... | . .
qdqdgfahefgllpsddgiak..kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.c

AIVMLCHENENDEEVCYQYWPST-SSGLIVGEYNIALLNEEIISNgCIERKFELKHTNKTsDKQQVKQYQITNWDSTGKMTNPQTILLVI---EEMYRTQ
..|..  | ..... | .|||   .     |  .. |   | ||.  . |....| ..|  . . |||.|.  ||  |    | |.. ..   ...  . 
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisd.yvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavserv

R--KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
.   .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.|. ||  |.. .  ..
tantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_CG7180_pd Subfamily CG7180 970-1216 1.1e-42 140.7 In-house 29-290 (296) alignment 
Range on Protein: 970-1216
Range on HMM: 29-290/296.0
QRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEeVCY
 . ..  ... ..| .|||  . .|... || |.    .|. ||||||.....  ||..|. | |. .|  .||... |... |.|.|... .  .  . 
leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myp

QYWPSTSsGLIVGEYNIALLNEEIISNgCIERKFELKHT---------NKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRG-----NTS
.||| .|     ||  . ...|.  .|    |.| |...         . . ..  ||..|.| |..  |.    . |. . .. |. |..      .  
sywpnks.keqygeifveiveekqyan.lkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegP

IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
.||..|| ..|| ...|.  .... . |. .|||. .|  |...|. |.....|. |....| ..
vvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 957-1211 1.9e-40 133.6 In-house 7-254 (267) alignment 
Range on Protein: 957-1211
Range on HMM: 7-254/267.0
GYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHE
 .|..|  ......    ..  ||..|...||  . || .. ||.|...  .|||| ...||| |.|||. . |. ||  .|...| |..|. ||.| . 
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv

NENDeeVcYQYWPST-SSGLIVGEYNIALLNeEIISNGCIERKFELKHTNKTSDkqQVKQYQITNWDSTGKmtNPQTILLVIEEMYRTQRKRGNTSIVVH
 ...  .  ..||          .  .     |   |      .|||  |...   .|  |   .|.   .  |   .  ..  . . | . ||  .||.
ftdn..i.rlfwPPkmgqakkyqdltvehsl.ekeendyqiitlelkfknesah..nvtlyyykkwnintn..nkpylkplfgilaknqlengnrPlvva

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQI
||| ||||  |  . . ... ||||| |.|. |.  | |..| |.| ..|  | ..
csdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel
subfamily_PTPN3_pd Subfamily PTPN3 975-1213 1.9e-40 133.6 In-house 33-272 (280) alignment 
Range on Protein: 975-1213
Range on HMM: 33-272/280.0
VTHNIASQNNDKNRSTQFLPPNNYRVPLKNEHPDYINAVFIN----GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPS
...   ..| .|||    || .. || ||... ||||| ..|    . .  . .|..  |. .|| .||.|. ..... ||||    |.    |.||||.
isaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

TSSGLIVGEYNIALLNEeIISNGCIERKFELKHTNkTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAA
|.  |  ||... . .|   .. .. |.. ||... |...... | | ..|   |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  
tedeleygefsvkceke.detksyvlrelvlkdke.tkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlille

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
|.. .  ..  . . ....  | |.   ||| .||. . . .|
talalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_PTPN9_pd Subfamily PTPN9 952-1216 1.6e-39 130.7 In-house 12-290 (297) alignment 
Range on Protein: 952-1216
Range on HMM: 12-290/297.0
KTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
..|. |  .... ... .    ....     |  ||| |  |  .. || |..    |. ||||| |..|||.||||| .  |. .| ..||.|. ...|
ekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqev

TAIVMLCHENENDEEVCYQYWP-STSSGLIVGEYNIALLNEEIIsNGCIERKFELKHTnKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQR-
  |||  .  |.    | |||| .. |    |..... .. |   .   .|..|.|.. ||.....|  .|.. |   |   . ...| |.|.. ..|  
lvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveee.edykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

--------KRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
        ..|   .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.|| .||.  .. || | 
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN13_pd Subfamily PTPN13 949-1217 2.5e-39 130.2 In-house 4-270 (273) alignment 
Range on Protein: 949-1217
Range on HMM: 4-270/273.0
LDTKTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEHPdYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRN
| .|  |   .|.|. |...    |...     .|.||||  . || .. ||.|..| . |||| .|.    |..  .|..  |. .|...||.|. ...
lqkkldqqqPaeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

VTAIVMLCHENENDEEVCYQYWPSTSS-GLIVGE-YNIALLNEEIISnGCIERKFELKHtNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQ
.. |.|. .| |...  | .|||.. .  | | . ....||. .  . |   |....|. ..... ..| . . ..|   |  .... .| .. |. | |
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkld.gfvvralavkd.sesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq

RkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLD
.   .. ||||||  .||| .. .  . ..  . .  .|| ..... | |. | ||| .||  .....|  | 
t..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 979-1217 1.9e-38 127.0 In-house 16-265 (270) alignment 
Range on Protein: 979-1217
Range on HMM: 16-265/270.0
IASQNNDKNRSTQFLPPNNYRVPLKNEHP----DYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSS
 | ...  ||... ||  . || |....      |||| ...|... ||..| | .|. .| ..||.|| ...||||||. . .|.  . | .|||. . 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

G-LIVGEYNIALLNEE-IISNGCIERKFELKhtnKTSDKQQVKQYQITNWDSTGK------MTNPQTILLVIEEMYRTQRKRGN-TSIVVHCSDTVGRSA
  . . . .|. |...   ..| | .. .|.   ........  .. ..|   |        .... .| ..... |....  . . ..||||. |||. 
ekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLD
.. |  ....  .... .|| ....  | ...  ||. .||. ... |. | .
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 982-1216 3.3e-38 126.1 In-house 37-277 (287) alignment 
Range on Protein: 982-1216
Range on HMM: 37-277/287.0
QNNDKNRSTQFLPPNNYRVPLKNEH---PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLIVG
 .  ||| .. || .. || | .|     ||||| .. .|....||| | .|.  | |.||... .......... .| |.    ||.|||     . ||
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYNIALLNEEIISNGCIERKFELKHTNkTSDKQQVKQYQITNWdsTGKMTNPQ---TILLVIE--EMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATT
 | . ||. .| .     | . | . . | . . |||... .|    |   |     | .|..  .    .|.  .   .|||..  .||| .. |  . 
GysvvlldydikePeygvralrlidle.trearvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

INKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
... .  | .|| .|.   | .. . ||.. |.. ... . .| 
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_PTPRN_pd Subfamily PTPRN 955-1212 1.3e-36 120.9 In-house 28-288 (297) alignment 
Range on Protein: 955-1212
Range on HMM: 28-288/297.0
QTGYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTA
..  |...  | .  . |   .   | .| .||||...|| .. || ||.    |. ||||| .|     .  |.| ...|. .|  .||.|. .. |. 
kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

IVMLCHENENDEEVCYQYWPSTSSGLiVGEYNIALLNEEIISNGCIERKFELKHTnKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGn
||.|.. .|.. . |..||| . | .  . |.. |. | | ..  . | | ||   .||. . | |.    | ..|  ......|     . .. | |  
ivnltrleeegvkqckrywpdeGsev.yhiyevhlvsehiwcddylvrsfylknl.qtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.

TSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIV
..||||||| .||. ....    .|.  |    ||.   |.  | |.|| |.| .|.. ... |
cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_PTPN1_pd Subfamily PTPN1 967-1208 6.5e-36 118.5 In-house 14-263 (290) alignment 
Range on Protein: 967-1208
Range on HMM: 14-263/290.0
QVTQRPDEVTHNI--ASQNNDKNRSTQFLPPNNYRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVC
....  ......     .|...||     | .  |. |.... ||||| ...  . |. .|..  |. ||.  ||.|. ...  |.||| .  |...  |
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

YQYWPSTSS--GLIVG--EYNIALLNEEIISNgCIERKFELKHtNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQR-KRGNTSIVVHCSDT
.||||.  .   |..   .... |..||. |.  . |..||.   || . ... ..  | |   |    |.. |  . .. ..   ..     |.|||  
aqywPqgeeekellledtklkvkliseerksy.ytvrllelen.lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGI
.|||  || . | .    | .    .|. .||   | .. | .|| .| .  
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfs
0036282 (Phosphotyrosine protein) phosphatases II 1008-1210 4.2e-34 113.1 In-house 3-164 (174) alignment 
Range on Protein: 1008-1210
Range on HMM: 3-164/174.0
DYINAVFINGYKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPStssglivgeyniallneeiisngcierkfelkhtNKT
||||| .....   . .|.   |.      ||.|. . ..|..|||..|.|.. . |..|||.                                  ...
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lre

SDKQQVKQYQITNWDSTGKMTNPQtILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTIQQYQG
. .. . ||. ..|.  |  . .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.||| .||. 
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IFQ
. .
lyy
subfamily_PTPN14_pd Subfamily PTPN14 962-1217 8.4e-34 111.9 In-house 26-297 (300) alignment 
Range on Protein: 962-1217
Range on HMM: 26-297/300.0
FTVLQQVTQRPDEVTHNI--ASQNNDKNRSTQFLPPNNYRVPL---KNEHPDYINAVFING--YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
||  ......  . . .     .|..|||  ..|| .. || |   |... .||||  |.     ... .|.| .|. .| ..||.|. . .|. |||| 
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

HENENDEEVCYQYWPST---SSGLIVGEYNIALLNEEiISNGCIERKFELKHTnKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNT-
.|.|.  | ...|.|..    . .  |....     |  |. .| ....|||   ......|   | |.|   |   .... |  .||.   .||  .. 
eeeedgkeksfkyfPkleskkktvefgkfkvttkfse.dsdsvittglklkhl.pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

-------SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLD
        ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. ||. ...... ||.
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0051429 (Phosphotyrosine protein) phosphatases II 1006-1219 5.4e-33 110.2 In-house 3-228 (272) alignment 
Range on Protein: 1006-1219
Range on HMM: 3-228/272.0
HPDYINAVFINGYKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVMLCHENENDEEVCYQYWP-----------STSSGLIVGEYNIALLNEEiIS
 ..|||| ...||     ..... .  |. .||..||..  . ....||.|..|.| . . |..|||           ..     .| . . || || . 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee.ll

NGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPqtILLVIEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------
. .| |...|... ....  .| ... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDSF
......  | | ||.||| .||. .....| .|.|.
leeaveelraqrpgavqteeqylflyeallellrsl
0041856 (Phosphotyrosine protein) phosphatases II 983-1215 2.4e-32 107.4 In-house 1-170 (182) alignment 
Range on Protein: 983-1215
Range on HMM: 1-170/182.0
NNDKNRSTQFLPPNNYRvplkneHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenendeevCYQYWPstssglivgeyni
| |||| . .||... |      ..||||| .. |.   . ||..  |. .|  .|..|. ....|.||.|.         ...|||             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

allneeiisngcierkfelkhtnkTSDKQQVKQYQITNWDSTGKMTnPQTILLVIEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvI
                        .  .... ||. ..|.  |  . ....|  |||...      .  ..||||  |||.....||   . .    | .
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.v

DVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVY
......|  | ..||.|.| .||. . ...| .
sleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 982-1213 3.9e-31 103.1 In-house 2-236 (237) alignment 
Range on Protein: 982-1213
Range on HMM: 2-236/237.0
QNNDKNRSTQFLPPNNYRVPLKNE--HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLIVG
.|. |||  .    .  || ||      ||||| ...|.    | .| |. |. ..  .||.|. . . . ||||    |..|. |..|||||      |
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

EYNIALLNEEIISNGCIeRKFELKHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCK
 . ..|  .| .|.  . | . | .  .  . . ..|||.| |   |   .  ..|    ..    ..    .  ..|||  |||...|    . . ..|
vltvslkkkeefsdytv.rslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

TEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
 . |.|... ..|   ..|  .|| .||  |.| .|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 971-1215 1e-30 101.5 In-house 35-235 (392) alignment 
Range on Protein: 971-1215
Range on HMM: 35-235/392.0
RPDEVTHniASQNNDKNRSTQFLPPNNYRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDeevcyq
 |. |..     |  |||  . || .. || |       . ||.|| .|.... .||.| ...|   .  .||.|. . |||.|.|. . .| |      
ypqtvaq..keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywpstssglivgeyniallneeiisngcierkfelkhtnKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMyrtQRKRGNTS--IVVHCSDTVGRSA
                                       |  |.. | |...|.|   .      ..| .|.|.   . . |. .  ...|||  |||..
.......................................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtg

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVY
.  .  . . ..|.  ..|||...   | ..|  ||| .||  |.  ||  
vvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 968-1205 3.7e-29 96.4 In-house 35-270 (301) alignment 
Range on Protein: 968-1205
Range on HMM: 35-270/301.0
VTQRPDEVTHNIASQNNDKNRSTQFlP--PNNYRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCY
 |   |..|.  |  ..||.|  .  |  |.     ... .   | | .|.   . . ||.. .|. ||. .|| |.   .|  ||||... |. ||.| 
ttidkdhitesyaylpkdkhryptv.PckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekce

QYWPST-SSGLIVGEYNIALLNEE-IISNGCIERKFELKHTNKTSDKQQVKQYQITNWDSTGkmtNPQTILLVIEEMYRTqrKRGNTSIVVHCSDTVGRS
.| |.. |. | .| ..| . |.| |...  ..|..|.. . .  . . |  || ..|   |    |..   . . |     |. .  ||||||. .|||
eylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrg...vPkshaelfdlmelv..kksekPivvhcsaGiGrs

AMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQY
  | ..    .. ...  |.. . ||  | ..  .||| .| 
vafigteylareveadptieltealkhlrehrwngvqtnsql
0046846 (Phosphotyrosine protein) phosphatases II 998-1217 3.1e-28 94.1 In-house 3-174 (176) alignment 
Range on Protein: 998-1217
Range on HMM: 3-174/176.0
YRVPLKNEHPDYINAVFINGYKekkaFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLIvgeyniallneeiisngcier
.|..  ....||||| .| |..    .|.   |. .|  .|..|. . ..||.|.|. | | .   |..|||   .  |                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kfelkhtnktsdkqqvkQYQITNWDSTGKMTNpQTILLVIEEMYRTQRKrGnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-
                 ||. ..|.  |  .  . .| ..|.... ... |   ..||||  .||.....||      ...|  ..|...|.  | |.| 
.................qylhlpwpDhgvpdl.elllellefirealke.g.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRpl

GSVQTIQQYQGIFQIVLVYLD
|.||| .||. . . .| .|.
gavqtpeQyrflyefellllk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 947-1218 4.2e-28 92.8 In-house 18-285 (290) alignment 
Range on Protein: 947-1218
Range on HMM: 18-285/290.0
SKLDTKTGQTGYEEQFTVLQQVTQRPDEVTHNIASQNN--DKNRSTQFLPPNNYRVPLKNEHP-DYINAVFINGYKekKAFIIAESPMFNTARNFWKMID
.   .| .  ..  ..    .     . .  .|  .|    |||  .    .  || ||. .. ||. | ...| |    ||... .. .|. ..|.|. 
asdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvl

DRNVTAIVMLCHENENDEEVCYQYWPSTSS-GLIVGEYNIALLNEEIISNGCIERKFELKHTnKTSDKQQVKQYQITNWDSTGkMTNPQtiLLVIeEMYR
. .|.||||||   |.    | ||.| ..   |  ||. .   .|.   .  | . . ...  ..  . ..| ..|  |     ... .  | ..  . |
qekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdk.dsGkehklkhlkikswpdks.valst..lall.rtlr

TQRKRgNTSIVVHCSDTVGRSAMFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLDS
. ||  .  .|||||  .||.  | |  ... .. ..|  .|. .. .. |  . .|||   ||  . .|.| .  .
ilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkd
0043147 (Phosphotyrosine protein) phosphatases II 1005-1209 4.8e-28 93.4 In-house 3-154 (172) alignment 
Range on Protein: 1005-1209
Range on HMM: 3-154/172.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEnendeevcyqywpstssglivgeyniallneeiisngcierkfelkHT
|. ||||| ....|   . ||.   |. ||   ||.|. ....|.||.|. .                                               .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................ly

NKTSDKQQVKQYQITNWDSTGKMtNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTIQ
...  .... ||. ..|.  |   ... .| ..| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||. .
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnps

QYQGIF
||. . 
qyrfly
0049260 (Phosphotyrosine protein) phosphatases II 1014-1209 2.4e-27 90.9 In-house 1-143 (152) alignment 
Range on Protein: 1014-1209
Range on HMM: 1-143/152.0
FINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWpstssglivgeyniallneeiisngcierkfelkhtnktsdkqqv
||.||. ...||... |. ||. .||.|. . ..|.||||. . |.... |.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

kQYQITNWDSTGKMTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTIQQYQGIF
 ||. ..|.  |  ...| .| ... . .  ... .  ..||||  |||.....||   .        ........  | ..||.|.. .|.. ..
.qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 985-1213 6.9e-27 89.1 In-house 9-237 (239) alignment 
Range on Protein: 985-1213
Range on HMM: 9-237/239.0
DKNRSTQFLPPNNYRVPLK----NEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLIvgE
 ||| .. .  .  || |.    . | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| ..|     .
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc..n

YNIALLNEEIISNgCIERKFELKHTNKTSDkQQVKQYQITNWDSTGKMTNpQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE
  ..| . |....  | | | . .  .| . . | ||..| |   |      | .| .      .   |    |.|||  |||.  |    . . ..| .
lrvtlrktevfad.yiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
  .|.|. .|. | ..|  ||| .||  |.  ||
ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 985-1213 7.1e-27 89.1 In-house 10-238 (239) alignment 
Range on Protein: 985-1213
Range on HMM: 10-238/239.0
DKNRSTQFLPPNNYRVPLK----NEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLIvgE
 ||| .. .  .  || |.    . | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| ..|     .
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc..n

YNIALLNEEIISNgCIERKFELKHTNKTSDkQQVKQYQITNWDSTGKMTNpQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE
  ..| . |....  | | | . .  .| . . | ||..| |   |      | .| .      .   |    |.|||  |||.  |    . . ..| .
lrvtlrktevfad.yiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
  .|.|. .|. | ..|  ||| .||  |.  ||
ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 958-1224 1.1e-26 88.6 In-house 18-287 (307) alignment 
Range on Protein: 958-1224
Range on HMM: 18-287/307.0
YEEQFTVLQQvtQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNE--HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
  ..|.|| .  . |. || .  | |.|||| ..    .. |. .| .    ||| | ..    . | || |. |. ||  .|| |. . .| ...|||.
lvdefrvlak..ktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

ENENDEEVCYQYWPSTSSG-LIVGEY--NIALLN--EEIIS--NGCIERKfELKhTNKTSDKQQVKQYQITNWDSTGkmtNPQTILLVIEEMYRTQRKrg
  |  .  | ||||      |. ||    |.. |   . ..  . .|.   .||  . ... . ....| .||   |    ||. |  |. .  .. .  
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvt.tlk.vdwaqksrtiqhlqwenwpdrg...vpqinltainlleavryd..

NTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL-DSF-ETYAN
.  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..||  ||  . ...| |. . . |||..
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyee
0049772 (Phosphotyrosine protein) phosphatases II 982-1222 1.9e-25 85.7 In-house 45-286 (314) alignment 
Range on Protein: 982-1222
Range on HMM: 45-286/314.0
QNNDKNRSTQFLPPNNYRVP--LKNEHPDYINAVFINGYkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVM---------------
 | ||||....|| .|....  | ..  ||||| ...|.   ..||... |. .|  .|          |.|.  .|.||  |||               
lnrdknryldilpadnrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------LCHENENDeevcyQYWPSTSSGLIVgeyniallneeiisngcierkfeL-------KhtnktsdKQQVKQYQITNWDStGKMTNPQTILLVIEE
      |.   .|       ...     |.                                        .... .|  ....  |    .. .. ..| 
AlgKtpllildgng.....neptaadlellk.......................eelydpelf.......erlgikylripvpD.gsaplledfdeflef

MYRTqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTIQQYQGIFQIVLVYLDSFETY
. .    . .. ..|||.. .||.. |..||  . ..   || .. ..|.  | . |     |.... .||. |....| ||. ....
ieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 947-1214 6.6e-25 82.4 In-house 12-277 (439) alignment 
Range on Protein: 947-1214
Range on HMM: 12-277/439.0
SKLDtKTGQTGYEEQFTVLQQVtqRPD-EVTHNIASQ--NNDKNRSTQFLPPNNYRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFW
 ||| |  |  ..| |  .. .  .|| ..  ..|.|  .. |||  .  . .  || |.      |  |||| .|.|| ..| .| .. |  .|. .||
ekld.knkqeifkeifekinst..spdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfw

KMIDDRNVTAIVMLCHENEndeevCYQYWPSTSSgLIVGEYNIALlNEEIISNGCIERKFELKH-TNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIE
... ..... ||||.   |      |.|||| .   . |.  .   . .|     . | | .    ..|  .. | |.. . |      ..   .|  . 
rlviekktvtivmltnlve.....sykywpsdae.vcygdiavrv.drnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflr

EMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLV
 .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||.. ||  |.. || 
ainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 981-1215 3.4e-23 76.7 In-house 35-268 (281) alignment 
Range on Protein: 981-1215
Range on HMM: 35-268/281.0
SQNNDKNRSTQFLPPNNYRVPLKN-----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGL
  || ||| ..    .  || ||      .  ||| | .|     |. .|... |  .|  .||.|| . | |||||||.  | . | | .|.|  .   
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

IVGEYNIALLNEEIISNGCIERKFELKHTNKTsdkQQVKQYQITNWDSTgKMTNPQTILLvieEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINK
.  .      ..  . .  .  ...| .  .|   . . ..   .|    .. .   ..|   .. |  | |  |  |.|||  ||||  . |   ... 
lqfdklsvsyedstvnkslvttrlnlsyeget...rlithwlwkewpdw.qvpessevml...kilrkirar.stppvihcsagvgrsgtlmaveialqs

CKTEG-VIDVFQVLKSQRIQ-KPGSVQTIQQYQGIFQIVLVY
 ..   . |. |..   |.  .  ||||.|||  |....| .
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0051082 (Phosphotyrosine protein) phosphatases II 1006-1210 7.6e-23 76.2 In-house 2-147 (151) alignment 
Range on Protein: 1006-1210
Range on HMM: 2-147/151.0
HPDYINAVFINGYkekkaFIIAESPmfntARNFWKMIDDRNVTAIVMLCHENENDeeVCYQYWPSTSsglivgeyniallneeiisngcierkfelkhtn
..||||. .. |.     ...   |       |.... . ....||.|. | |..   |..|.|...                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

ktsdkQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTIQQY
      .|....|..|. .|  ......| ..|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||. ||.
.....ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

QGIFQ
. ...
lfqlf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 982-1216 1.4e-22 75.1 In-house 42-271 (288) alignment 
Range on Protein: 982-1216
Range on HMM: 42-271/288.0
QNNDKNRSTQFLPPNNYRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLIVGEYN
.|  ..| ..    .  || |...   ||.|  .   | |. .| |..|.  |  ..|||. . .|  |||||.  |   |   .|.||     .    .
anptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

IALLNEEIisnGCIERK--FELKHTNKTSDKQQ-VKQYQITNWDSTGKMTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 .   ..      |..     | . .|. .... ||.  . .||  |   | .. | ..| .     |  .  ||||.|  |||.. .      ..  . 
ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrl

EGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
.  . . ..|.. | ..  ..|| .||  ....|| .|
ddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_ptpA1_pd Subfamily ptpA1 960-1175 1.8e-22 74.7 In-house 25-255 (418) alignment 
Range on Protein: 960-1175
Range on HMM: 25-255/418.0
EQFTVLQQVtQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKN----EHPDYINAVFINGYKEkKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
|.| .|..    | | .     .|  ||| |. || |  || ||.    |  ||||| .|.|    | || .. |. ||  .||.|. .  .  |||| .
eefrllees.vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsr

ENENDEEVCYQYWPSTSSGL----------IVGEYNIALLneEIISN---GCIERKFELKHTNKTSDkqqVKQYQITNWDSTG--KMTNPQTILLVIEEM
|.||    | .|||    |           ..| |.. |.  |.| .     | |.  |    .| |   . |||   |        |.|   ||     
esencrikcdrywpeqiggeqfsiygngnevfgtysvelv..eviqdpereiitrnirltfegetrd...itqyqyegwpdhnipdhtqpfrqllhsitn

YRTQ---RKRGNTSIVVHCSDTVGRSAMFCAAATTINK
 . |       |  |.||||  |||.  ||.|   ..|
rqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk
PTPc_DSPc_SM00012 1112-1212 2.5e-22 74.4 In-house 1-103 (105) alignment 
Range on Protein: 1112-1212
Range on HMM: 1-103/105.0
QVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTIQQYQGIF
.||.|..|.|  .|. .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| .||. . 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

QIV
...
ral
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 972-1215 7e-22 72.7 In-house 24-269 (285) alignment 
Range on Protein: 972-1215
Range on HMM: 24-269/285.0
PDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEHPDYINAVFIN-GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPS
| ..|.     | | || ..    .. || |||   ||| | ..    |.. ..| .. |. .|  .||.|| . ... ..|||   |   | |  |.| 
ppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

TSSGLI-VGEYNIALL--NEEIISnGCIERKFELKHT-NKTSDKQQVKQYQITNWDSTgkmTNPQTILLVIeEMYRTQRK--RGNTSIVVHCSDTVGRSA
    .. .|.|.|.|   .|| |. | |   . .  | . .|.   ... |.  |        |.    .| |.|.  .|    .. |.||||  |||.|
klgevvkfgkyeitlteckeeaia.gtilnaltvintedasseplymnhvqvpwwpdq...lapedarpmi.elykwvkkvnpkekpicvhcsagvgrta

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVY
 |     .  .   .  |.......  |  .  .||.  |.  .. ... |
tfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey
0044763 (Phosphotyrosine protein) phosphatases II 1002-1211 2.7e-21 71.4 In-house 13-166 (178) alignment 
Range on Protein: 1002-1211
Range on HMM: 13-166/178.0
LKNEHPDYINAVFINGYkekkaFIIAESPMfntaRNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSglivgeyniallneeiisngcierkfel
   |  |||||..| ..     ....  |.     ...... . ..|.||.|..| |.  . |..|||.  .                            
eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag............................

khtnktsdkqqvKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQT
             ||. ....  |  . .. .| ..| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..
............iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn

IQQYQGIFQI
  |.. . ..
pgqlrqLyef
subfamily_egg_pd Subfamily egg 957-1216 6.9e-21 69.2 In-house 15-270 (307) alignment 
Range on Protein: 957-1216
Range on HMM: 15-270/307.0
GYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVM
..| .. ||......   .|. ... | .| || .    .  || |. ..     |.| |  ..|      ||.|..|. ||  .||.|.   .|  |||
elerrlevleesvde.islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

LCHENENdeEVCYQYWPSTSS-GLIV--GEYNIALLNEEIISNgCIERKFELKHTNKTSDKQQVKQYQiTNWDSTGKMTNPQTILlvieemyRTQRKRgN
|    |.  | |  ||| . |  |..  | ..|  |. .  ..  . |  .||      ... .. .|  ... ....  |  .|       |  |.   
ltsrkes..erceyywpkaesdslvtvpGslrienlkvdskad.plfrvtklklvGgddeerflehwq.gdvnnssdvysplrvl.......rklrnl.s

TSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTIQQYQGIFQIVLVYL
. .||.. . | ..| . |. ... .    | |  . ||..    | ... ||... .|  ....||...
kpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 957-1217 2e-20 67.7 In-house 23-288 (305) alignment 
Range on Protein: 957-1217
Range on HMM: 23-288/305.0
GYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEHP-DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
|  ..|. .... .  . .     .|...|||  .    .| || |..  | .|| | ..    . | || ...|. .|  .|| |  . .| || ||| 
glraefvamkrfndf.ekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcn

ENENDEEVCYQYWPSTSSGLIVGEYNIALLNEEIISNGCI----ERKFELKHTN-----KTSDKQQVKQYQITNWDSTGKMTNPQTIllvIEEMYRTQRK
  |   . |..|..|     .  | .   .   . | . .    . | ....|        .....|..|   .|   |  .  ..|   .| . ...  
llekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlai...lellekarps

RGntSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYLD
.|   ||||||  .||.         ...  .  .|.   ..|.  | |.  |.|| .||  . |..| |. 
kg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 982-1216 2.9e-20 67.1 In-house 54-289 (305) alignment 
Range on Protein: 982-1216
Range on HMM: 54-289/305.0
QNNDKNRSTQFLPPNNYRVPLKNEHP-DYINAVFING-YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLIvgE
 .  ||| ..    ..  | |..  | ||| | ..      .| || |. |. .|  .|| |. ...|  |||||.  |     | |||| .       |
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl..e

YNIALLNEEIISNGCIERKFELKHTNK-----TSDKQQVKQYQITNWDSTGKmtnPQTILLVIEEMyRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTIN
 .  .. |..  .  .||  |.. |        ..|  |.. | |.|   |    |   |  .| .  . |   .  ||||||  .||.    |    ..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv...ppckltslell.sair.gskvpivvhcsagigrtgtivaieyile

KCKTE-GVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
|   .  .  . ...|. | |.  |.|.  ||  | ...| |.
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 952-1215 1.9e-18 61.1 In-house 23-289 (310) alignment 
Range on Protein: 952-1215
Range on HMM: 23-289/310.0
KTGQTGYEEQFTVLQqvTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLK---NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
| |  |   |.  |.  ...   .|..   ..  ||| .. .  .. || ||     . ||| | ...    ...|| .. |.  |  .||.|| .    
klgieglvkqyrkld..akqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqerae

AIVMLCHENENDEEVCYQYWPSTSSGLIVGEYNIALLNEEIISNGCIERKFELKHTNKTSDKQQV--K--QYQITNWDSTGKMTNPQTILLVIEEMYRTQ
.|..||.  |.    |  ||||       |   .. |.|        .    .   |   |.|    |  . .. .|     .  |.     . .   .|
silllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaq

RKRGNtsIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVY
 . |    |||||  ..|  . .|   .|.| .    .|. .|    . ..   .||  ||  | .. ...
vrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1019-1211 2.6e-17 57.7 In-house 2-199 (199) alignment 
Range on Protein: 1019-1211
Range on HMM: 2-199/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGliVGEYNIALLNEEIISNGCIERKFELKHTNKT---SDKQQVKQ
| .. .| .. |. .|  .||.|. .     |||.  .. | |     |||.| ||  .|.|    .  . |.         |  ||.|      ... .
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesg..tgkygslsvttktittkpdytitaliltnnttappstreish

YQITNWDSTgkmTNPQTIL-----LVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTIQQYQG
||.| |      | |.  |     .   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . ..|.|. 
yqftswkek...ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynf

IFQI
|.|.
iyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1020-1211 3.4e-17 57.3 In-house 2-198 (198) alignment 
Range on Protein: 1020-1211
Range on HMM: 2-198/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGliVGEYNIALLNEEIISNGCIERKFELKHTNKT---SDKQQVKQY
 .. .| .. |. .|  .||.|. .     |||.  .. | |     |||.| ||  .|.|    .  . |.         |  ||.|      ... .|
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesg..tgkygslsvttktittkpdytitaliltnnttappstreishy

QITNWDSTgkmTNPQTIL-----LVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTIQQYQGI
|.| |      | |.  |     .   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |
qftswkek...ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfi

FQI
.|.
yqv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1007-1216 4.2e-17 57.2 In-house 46-259 (290) alignment 
Range on Protein: 1007-1216
Range on HMM: 46-259/290.0
PDYINAVFINgYKEKKAFIIAESPMFNT-------ARNFWKMIDDRNVTAIVMLCHENENDEE----VCYQYWPSTSS-GLIVGEYNIALlNEEIISNGC
 ||| | ..  . .  ..|. .||  ..         .|| |. . .|. .||||  .|....     | .| | .    | ..  ..    . .  .. 
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.kskekeddv

IERKFELKHTNKtsDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRI
..|. ..|. ..   . .|. ... .|...    ...|.| .|. .     |  .| ..||| | . |||.. |      |   |.| . . .|||. | 
etRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

QKPGSVQTIQQYQGIFQIVLVYL
|.   ... ...  .   .....
qralaitsalelafvdagivlla
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 978-1216 5.4e-17 56.2 In-house 46-285 (302) alignment 
Range on Protein: 978-1216
Range on HMM: 46-285/302.0
NIASQNNDKNRSTQFLPPNNYRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTA---RNFWKMIDDRNVTAIVMLCHENENDEeVCYQYWPSTSSG
..  .| .||.|...  ... .| |..|  .|.||  ..  . ..  |.|  |  ...    .||.|. ..... .|.|  |.| ..    ...| .|  
kafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

LIvgEYNIALLNEEIISNGCIER-KFELKH-TNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATT
    ||.   .|   ...   |. .. .    .  |.   .. | .||| ..   ..  ..   .....      .. ..|.     .|| ..| ..|..
yk..eygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfak.kikadentvivSknGaGRagafltlava

INKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
..| ...    . ...|| | |.| .|....||  .. ..|.|.
veklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 981-1085 8.6e-16 52.6 In-house 31-140 (297) alignment 
Range on Protein: 981-1085
Range on HMM: 31-140/297.0
SQNNDKNRSTQFLPPNNYRVPLKNEHP--DYINAVFINGYKEKK--AFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSG-L
.    ||| .. |  .. || |..  .  ||||| ..   .|..   .|.|. |. .|  .||... ...| .|||... .|.  . |. ||||.  . |
nsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

IVGEYNIALL
  |.. .  |
kagdvvvefl
subfamily_CG42327_pd Subfamily CG42327 960-1140 1.1e-15 52.2 In-house 9-190 (319) alignment 
Range on Protein: 960-1140
Range on HMM: 9-190/319.0
EQFTVLQQVTQRPDevthNIASQNNDKNRSTQFLPPNNYRVPLK----NEHPDYINAVFINGYKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIVMLC
|.|  | |.  | |    ..    .||.|  . .|  . || |.    ...  |..| .. ||.. .. .| |. .. ... .||... ...   || |.
eefrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

HENENDEEVCYQYWPSTSSG---LIVGEYNIALLNEEIISNGCIErKFELKHTNKtSDKQQVKQYQItNWDSTGKMTNPQTILLVIEEM
   |.  .|| .|.|.  ..      |.. ..| . |.  .  |   . ||. .| .  ...  |   .|  ..  ....... .. |.
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryais.tlllkrvdk.eesrelthywy.kwleaevPaeeaaliamllev
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 973-1205 1.6e-15 51.9 In-house 19-210 (255) alignment 
Range on Protein: 973-1205
Range on HMM: 19-210/255.0
DEVTHNIASQNNDKNRSTQFLppnnyrvplknehpdyinavfingykekkafiiaespmfnTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTS
|. |.... ... |..... |                                        |  .|...|   . . .||||  .|.. | | .|.|   
dvctehvkPekdkkrknlysl........................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplek

SG-LIVGEYNIALLNeeiISNGCIERKFELKHTN-KTSDKQQVKQYQITNWDSTGKMTNPQTILLVieemYRTQRKRgnTSIVVHCSDTVGRSAMFCAAA
 . |.. . |..  .    |.  . |  |.  |  .    ..|| |. . |       ... || .    ..  |.    |.|||||  .|||| |  | 
deklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilni....lkvvrds..ksvvvhCstGiGrsaafvlae

TTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTIQQY
           . .| . .|  ..|.  | .......|  | 
lvyqkmirsldttet.veldylslleelrskrkraihtPlql
I-set Immunoglobulin I-set domain 781-866 3e-15 47.8 Pfam-A 2-90 (90) alignment 
Range on Protein: 781-866
Range on HMM: 2-90/90.0
IIEEFPNDVTSEEGHEILFKVKFKGTPTPSFNWYHNGEPVTDDYAHELRGDG---SLLLVSVEEKHKGTYRFVANNDAGTVSQQLVLTV
 ... ..||. .|| .. .... .|.|.||..|...|.... .  .... ..   .| . .||.. .|.|. .|.| ||...... |.|
kftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1027-1208 3.1e-15 50.4 In-house 96-280 (302) alignment 
Range on Protein: 1027-1208
Range on HMM: 96-280/302.0
AESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSG-LIVGEYNIALLN-EEIISNGCIERKFEL---KHTNKTS---DKQQVKQYQI
   |  .|   .| .|.. ||. .| ||.  |..|. | .|.     | |  |.| .  .. .. ...    ..| |   . .|.      |. |.  . 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWDSTGKMTNPQTILLVIEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGI
. |   |   ...| | ..   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||. ||   .
sawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 1026-1204 1e-14 49.1 In-house 42-215 (263) alignment 
Range on Protein: 1026-1204
Range on HMM: 42-215/263.0
IaespMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSG-LIVGEYNIALLNeeIISnGCIERKFELKH-TNKTSDKQQVKQYQITNWDS
.    . .|  .|...|   . . .||||  ||.. | | .|.|    . ... . |..  .  ..|   . .  ||    ..    ..||.|. . |  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttk..vqs.dvllktlellstlgeKkkthtvkhysykgWie

TGKMTNPQTILLVIeemyRTQRKRgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTIQQ
.   .... || ..    .  |.    |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......|  |
kndpelareilnil....kvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtPmq
subfamily_PTPRD_pd Subfamily PTPRD 913-1006 1.7e-14 48.4 In-house 267-361 (564) alignment 
Range on Protein: 913-1006
Range on HMM: 267-361/564.0
IDQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSKLDTKTGQTGYEEQFTVLQ-QVTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEH
 .||||. .|.|| ..||||.|.|.| .  ...... ...|..||.|  |  |.  . . ..| .    ..|..||| .. |. .. || |....
eeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsair
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 965-1133 1.9e-14 47.9 In-house 76-242 (244) alignment 
Range on Protein: 965-1133
Range on HMM: 76-242/244.0
LQQVTQRPDEV--THNIASQNNDKNRSTQFLPPNNYRVPLKNEH--PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENEND
  |   |||       .  .|. |||    || .  |||| .      |||| |.        .|... |. .|. .||||. .| |  .|.|   .|.|
gsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed

EevcyqYWPStSSGLIVGEYNIA--LLNEEIISNgCIERKFELKHTNKtSDKQQVKQYQITNWDSTGKMTNPQTI
|     |||  |  |   | .|.  | . . . |     ..|..   .   .| .  .||.|| | |   |   |
e.....ywpd.seplewyeeditvtltdrdefkn.ikasnleiesdmn.eshqaltmfqisnwpsdgttpndhfi
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 995-1222 2.1e-14 47.9 In-house 55-282 (312) alignment 
Range on Protein: 995-1222
Range on HMM: 55-282/312.0
PNNYRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTsSGLIVGE-YNIAL-LNEEIISN
 .  |  |  .   || | |..     . |.....|. ||. .||..      |.|..||   |.  | | .|      |..  | . .      ||   
wdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi.vgfvdledhrvyteycteieig

GCIERKFE---LKHT-NKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAA---TTINKCKTEGVIDVF
|    |     ||   . | .. ....|| . |   |     .| | ..  .     |. .  .. |||  |||.  ..      ... . . . | |.|
gkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsf

QVLKSQRIQkpgSVQTIQQYQGIFQIVLVYLDSFETY
 .|. .| .   ||... ||   ...|| .| |   |
vllrkdrar...svrvfpqyvyalrcvleflyskgly
fn3 Fibronectin type III domain 475-548 5.1e-14 45.4 Pfam-A 8-83 (85) alignment 
Range on Protein: 475-548
Range on HMM: 8-83/85.0
VHSKNPDAILIVWNPPTIPNGIITVYEIRYRESTSTS---PYNITNTTNtYYSIVGLIPNTSYTIGVRAYTSIGPGE
|.. ... . . |.||. ..| || ||..|||.....    .....||.  . . || |.|.|.. |.|..  | |.
vsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 372-455 1.3e-13 44.1 Pfam-A 2-83 (85) alignment 
Range on Protein: 372-455
Range on HMM: 2-83/85.0
PVDDIIFSSVESVSMTVSWDEVPcnESNGPITGYYLTYTNITSNT-SYTVNITGGDNrMYNLTGLIPYTSYTVSIIPYNYNMNGP
.. .. .|.| | |.|.||.. .  . .|||||| ..| . ...  . ......  .  ..|||| |.|.|....  .| . .||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1110-1216 1.3e-13 45.1 In-house 88-194 (440) alignment 
Range on Protein: 1110-1216
Range on HMM: 88-194/440.0
KQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIF
 . .|||.   |   |       .| .|...  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| .||  ..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QIVLVYL
. ||  |
eavlegl
0048179 (Phosphotyrosine protein) phosphatases II 1040-1209 2.5e-13 45.5 In-house 23-138 (144) alignment 
Range on Protein: 1040-1209
Range on HMM: 23-138/144.0
KMIDDRNVTAIVMLCHENENDEEVCYqywpstssglivgeyniallneeiisngcierkfelkhtnktsdkqqVKQYQITNWDSTGKMTNPQTILLVIEE
... . ..|... |..| |.... ..                                               . ||. ..|.  |  . .. .| ..| 
ellkklgittvinlteeyepeflere...............................................giqylhlpwpDhgvpdllellleflef

MYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTIQQYQGIF
. . ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|.. .|.. . 
ieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl
0048076 (Phosphotyrosine protein) phosphatases II 1073-1213 3.1e-13 45.1 In-house 9-140 (145) alignment 
Range on Protein: 1073-1213
Range on HMM: 9-140/145.0
SGLIVGEYNiALLNEEIISNGCIERKFELkHTNKTSDKQQVKQYQITNWDSTGKMTNPQTILLVIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATT
 || .| .  . |. | . .  | . . |  ....  .... ||. ..|.  |  . ....| ..| . . ...  .  ..||||  |||.....||   
pglylgslp.taldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylm

INkcktEGvIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
.     .| ......|.  | | ||.|.. .|.. ... .|
ll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 974-1108 7.4e-12 39.6 In-house 40-189 (350) alignment 
Range on Protein: 974-1108
Range on HMM: 40-189/350.0
EVTHNIasQNNDKNRSTQFLPPNNYRVPLK------------NEHPDYINAVFINGY----KEKKAF--IIAESPMFNTARNFWKMIDDRNVTAIVMLCH
.... .  .   ||| .. || .  || ||             .  ||||| ...      . .  |  | . .|. .|  .|.|.|   .|. |..|  
ilseGv..elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

ENENDEEVCYQYWPSTSSGLIvgEYNIALLNEEI-ISNGCIERKFELKHTNKTS
. |.. | ||.||.  |   |     .|   |.|   |..  . ...|..    
dvelnlekcyrYWqegsyddi..tvklaskwenimgindsslysadvkkeasdn
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1006-1129 2.4e-10 34.8 In-house 12-129 (130) alignment 
Range on Protein: 1006-1129
Range on HMM: 12-129/130.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEevcyqYWPStSSGLIVGEYNIALLNEEIISNGCIERKFELKHTN
  .|||| |.      . .. .. |. .|. .||||. .| |  .|.|   .|.||     |||  |  |   | .| .   .      |. ..   . .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpd.sePlewyeediivtltdrdefknikasnleiesd

KTSDKQQVKQYQITNWDSTGKMTN
    .| .  .||.|| | |   |
lneshqaltmfqisnwpsdgttpn
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1139-1214 4.4e-10 33.9 In-house 219-293 (297) alignment 
Range on Protein: 1139-1214
Range on HMM: 219-293/297.0
EMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLV
| .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||..|.. ....|| 
eslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1015-1105 9.8e-10 32.3 In-house 229-315 (440) alignment 
Range on Protein: 1015-1105
Range on HMM: 229-315/440.0
INGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENendEEVCYQYWPSTSSGLIVGEYNIALLNEEIIsNGCIERKFELKHTN
..||  |.||| .. |.  |  .||... | ....|.||   |   .  |  |||  .  .  | . .     | . |    | .|||. .
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqln...dktcsiywpvntrsvtfgpftvghkgsenm.nrvkvrtlelkyke
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1004-1174 1.7e-09 31.5 In-house 87-290 (349) alignment 
Range on Protein: 1004-1174
Range on HMM: 87-290/349.0
NEHPDYINAVFIN--GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTS-SGLIVGEY----NIA-------------
    ||||| ...   .. .| .|    |.  |  .|.|.|   .|  .. | ...|.. | |..||   | |.  |       .||             
gklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyianvqGnslrvstvk

--LLNEEIISNGCIERKFELKHTNKTSDKQ--QVKQYQITNWDSTGKMTNPQTILLVIE-------EMY-RTQR-KRGNTSIVVHCSDTVGRSAMFCAAA
    ... ... |.. . ..... . . ..  .. | |. ||  .. . ||..||  .|       ... |    .   ....||||   ||. ...   
dtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtld

TTIN
  ..
llls
subfamily_eak_pd Subfamily eak 991-1125 5.5e-09 29.9 In-house 59-193 (332) alignment 
Range on Protein: 991-1125
Range on HMM: 59-193/332.0
QFLPPNNYRVPL---KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTS-SGLIVGEYNIALLN
. .| . | | |   . ..  ||||  ..  .  . .|..  .  .    ||.|. ...  |||.| .. |.. |   .|.|  .   |  | ...   .
kivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverke

EeIISNGCIERKFELKHTNKTsdkQQVKQYQITNWDSTG
  .  |    |..||.  |.|    .|. |..  |  | 
f.vkrniletrllelskGnet...hrvlhykvfGwtett
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 968-1210 7.2e-09 29.7 In-house 32-273 (303) alignment 
Range on Protein: 968-1210
Range on HMM: 32-273/303.0
VTQRPDEVTHNIASQNNDKNRSTQFLPPNNYRVPLKNEhpDYINAVFINGYKEKKAfIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQY
|.  | .|..|   .| |||| .. .  .  .| | .    || | ...   .||| |... |.  || .||.|| ...|  ...|  ..| |.      
vsylppsvsknqfvknmdknrfvdvicldhskvklsds..syihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv

WPSTSSGLIVGEYNIALLNEEiisNGCIERKFELKHT--NKTSDKQQVKQYQITNWDSTGKMTN-PQTILLVIEEMYRTQRKRGNTSIVVHCS-DTVGRS
.|     |   |  | . .     .  .   . ||     . . |  .. ..  .|  .   ..    ..  | ..    ||  ...  |. |   .||.
fprnqdflkfeersirvgefk...rvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgra

AMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQ
  |.   |.     . .  .|. ..|.  |  .  .|| . |.  .. 
gtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvyt
subfamily_CG42327_pd Subfamily CG42327 1144-1215 1.4e-08 28.8 In-house 242-314 (319) alignment 
Range on Protein: 1144-1215
Range on HMM: 242-314/319.0
QRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVY
 ..  .  .|||||| |||. .  |.  .|.. ..    .|. |.. | | ..  .|.|..||. |....  |
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 985-1062 3.2e-08 27.5 In-house 48-124 (347) alignment 
Range on Protein: 985-1062
Range on HMM: 48-124/347.0
DKNRSTQFLPPNNYRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLcHENENDEE
 .. .   | |.. .    ..   ||||  |.  . .| .|... |. .| |.||||.   .|| .| .  |  .|| 
lidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti.fepikdea
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 887-941 4.2e-08 27.4 In-house 1-55 (290) alignment 
Range on Protein: 887-941
Range on HMM: 1-55/290.0
LVPVGQFGEFVANGHAKGNEGFRNQFIDQYIFVNDavlESVTCGNTQVDS---RNARI
|.||..||||||||||||||||||||     . ..   ..|| |.|. ..   | |.|
lipvdkfgefvanghakgnegfrnqfkmldsgese...htvtvgltssnkllnRfani
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 887-912 1.5e-07 25.7 In-house 1-26 (287) alignment 
Range on Protein: 887-912
Range on HMM: 1-26/287.0
LVPVGQFGEFVANGHAKGNEGFRNQF
|.||..||||||.|||||||||.|||
lipvekfgefvakghakgnegfknqf
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1036-1216 1.5e-07 24.3 In-house 132-309 (346) alignment 
Range on Protein: 1036-1216
Range on HMM: 132-309/346.0
RNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTSSGLIVGEYNIALLNEEiISNGCIERKFELKHtNKTSDKQQVKQYQITNWDSTGKMTNPQTILL
 .|| || . ..  . ..  ..   .     .          |   |     . .|    |   |.   .  ||   .. .. . |    .  .   |. 
edfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrrad.vsgdpkeytievlp.egnsdsvicqvhhhapwkhlqqppktlpiik

VIEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVLVYL
.| ...  ...  |. . |      ||.  |  |  .||.       ......|. . |.||.|... || .|. ||. |.
mihqfls.ekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_PTPRK_pd Subfamily PTPRK 912-962 2.7e-07 24.7 In-house 262-312 (314) alignment 
Range on Protein: 912-962
Range on HMM: 262-312/314.0
FIDQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSKLDTKTGQTGYEEQF
  .||.|. |..||.. ||.| .   . . ..  ...||..|  .  .|.|
teeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeef
Ig_2 Immunoglobulin domain 789-865 7.1e-07 21.2 Pfam-A 9-79 (80) alignment 
Range on Protein: 789-865
Range on HMM: 9-79/80.0
VTSEEGHEILFKVKFKGTPTPSFNWYHNGEPVTDDYAHelrgdgsLLLVSVEEKHKGTYRFVANNDA-GTVSQQLVLT
.. .||. . .  ...| |||.. ||..||...   .        |.. .|.....|||. .| |.  ...|. . .|
tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsvevt
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 982-1058 1.3e-06 22.1 In-house 33-112 (332) alignment 
Range on Protein: 982-1058
Range on HMM: 33-112/332.0
QNNDKNRSTQFLPPNNYRVPLK--NEHPDYINAVFINGYKEKKAFIIAESPMFN-TARNFWKMIDDRNVTAIVMLCHENE
.| | ||  ..   .  || |   . . |. || ...|| .| |.|.|..|. . |   ||.|. .|. . |...   .|
nnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdide
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 911-963 4.9e-06 20.8 In-house 264-316 (318) alignment 
Range on Protein: 911-963
Range on HMM: 264-316/318.0
QFIDQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSKLDTKTGQTGYEEQFT
|  |||.|. |..|| ...|.|.||... |   ... . |...|.|  . .| 
qtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 911-962 5e-06 20.8 In-house 267-318 (319) alignment 
Range on Protein: 911-962
Range on HMM: 267-318/319.0
QFIDQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSKLDTKTGQTGYEEQF
|  .||.|. .|.|| |..|.|... .. |  . .... ...||.|| | .|
qrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1107-1213 6e-06 20.2 In-house 211-341 (350) alignment 
Range on Protein: 1107-1213
Range on HMM: 211-341/350.0
TSDKQQVKQYQITNWDSTGKMTNPQTILLVIE--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAATTINK-------------CK--TEGV
.||   | | |. ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....    ...              .  ..  
asdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktr

IDVFQVLKSQRIQKPGSVQTIQQYQGIFQIVL
  ......  | |.   ||...|.  |.. .|
DlisiivnelrkqrismvqnldqfifiYeall
fn3 Fibronectin type III domain 278-351 6.8e-06 19.3 Pfam-A 1-76 (85) alignment 
Range on Protein: 278-351
Range on HMM: 1-76/85.0
DAPTDLTATRLstGLAHVRLSWSTV----SGATGYEVYYQLSVSNN-SISLDtTSLTTIDITASTLIRGNTYTFYVVSY
.||..|...    .   ..||||      .  ||||| |. . ... . . . .. ||   | . |  | .|.| | ..
saPenlsvsev..tstsltlsWsppkdgggpitgYeveyrekgggeewkeft.vprtttsvtltgLkpgteYefrVqav