Gene PTPRD-13 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP066_AA protein Get Run
AqueP066_AA_590-753 phosphatase_domain Get Run
AqueP066_AA_767-1040 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 768-1048 4.5e-157 516.4 In-house 7-287 (287) alignment 
Range on Protein: 768-1048
Range on HMM: 7-287/287.0
FNRMSKPDTKTGQTGYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
|..... ....|..|...|||||.|||||.|||||||||||.||||.||.|.|.|.||.||.|||||||||||.||||||||||||||||||||||||.|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkli

DDRNVTAIVMLCHENENDEEVCYQYWPSTQSaLVIGEYNITLLNEDKSNKYIERKFEVKNNN-TGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRT
||||||||||||.|.||||||||||||...| .|.|||||.||||.....|||||.||||.| .|.||.|.|.|||||||||.|..||||||.|||||.|
ddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

QRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFETYSNF
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||. ||.....|||.||.||||||.|
qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 774-1046 6.7e-127 417.3 In-house 13-290 (290) alignment 
Range on Protein: 774-1046
Range on HMM: 13-290/290.0
PDTKTGQTGYEEQFTVLQQvTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLK--NEHPD----YINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
 ....|..|...||..|.. .... .||....|.|. .||..........|..|.  ..|.|    ||||..|.||||||..|....|..||...|||.|
nghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

DDRNVTAIVMLCHENENDEEVCYQYWPSTQSALvIGEYNITLLNEDKSNKYIERKFEVKNNNT-GAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRT
....||.||||....|.....|.||||.....  .||..|.|||| . |.|||||.||||.|. ||||||||.|||||||||.|.|||||||.|||||.|
wqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemykt

QRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFETYS
|||||||||||||||||||||.||||||||||||||||||||||||||||||||||||  ||||.||||| ||.||||||
qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 778-1044 1.2e-73 243.0 In-house 19-288 (305) alignment 
Range on Protein: 778-1044
Range on HMM: 19-288/305.0
TGQTGYEEQFTVLQQVtQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEHP--DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
. ..|.|.|.  |..  . . .|... |........... |...  ..  |....  ||||| ...|||.||..|.| .|. || ..||..| .  |. |
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLCHENENDEEVCYQYWPSTQSA-LVIGEYNITLLNEDKSNKYIERKFEVKN-NNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRGNT
|||..  |.... |.|||| ...    .||....| .| . . |||||... . ..   ...|.|.|.|.|   | .. . ..| .|... ..|.|  ..
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFET
...||||..|||. .|.|    ....|.|.|.|||.|||  | .... |||  ||. .....  ......|
pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 755-1045 5.1e-73 240.9 In-house 1-296 (298) alignment 
Range on Protein: 755-1045
Range on HMM: 1-296/298.0
GNTQVDSRNARIVFNRMSKPDTKTGQTGYEEQFTVLQQVTQRPDEVTHNIA--SQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKA
|||...... .. ...... . |.. |||...|  |..|... .| ....|  ..|..||| .. .. .  || |..    |. |||||.|...||...|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSAlVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTG
||... |. .|  .||.|. ......||||   .| |.  . .|||.....   || ...||....  ..| ||..|.....  ...| |.. |.| . |
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

EVKNPQTILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFETY
. .| ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.|||  ||  ....|| .|.||...
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
0050432 (Phosphotyrosine protein) phosphatases II 768-1047 7.2e-73 240.9 In-house 29-307 (308) alignment 
Range on Protein: 768-1047
Range on HMM: 29-307/308.0
FNRMSKPDTKTGQTGYEEQFTVLQQVTQrPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLkNEHPDYINAVFINGY--KEKKAFIIAESPMFNTARNFWK
 . . . . ... ...||.|  |..|.  . | ..    .| ||||.. .||  . || | .|. ||||| ...||  | ...||.. .|. ||  .||.
ldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MIDDRNVTAIVMLCHENENDEEVCYQYWPST--QSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEM
|. . ||. ||||. . ||. | |.||||..  .. |..| . .|||.|.. . |. |..|..|...|    ||.|. |||   |   .|. .| ..|..
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

YRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFETYSN
 ...   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||  ||. .....| ||....|. |
rksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkln
0047943 (Phosphotyrosine protein) phosphatases II 775-1039 3.5e-70 231.9 In-house 6-272 (273) alignment 
Range on Protein: 775-1039
Range on HMM: 6-272/273.0
DTKTGQTGYEEQFTVLQQVTQrPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
....| |...|.|  |....  . . .. .  .| ||||.. .|| .. || |.... ||||| ...||. |..||... |. ||  .||.|. . ||. 
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLCHENENDEEVCYQYWPSTQS--ALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKR-G
||||. . |.. | |.||||...    |. |.. .|||.|.. . |. |..|..|..|| .  ||.|. |.|   |   ... .| .||.. .....  .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||  ||. . ...| ||
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 776-1045 9.9e-70 230.5 In-house 8-283 (297) alignment 
Range on Protein: 776-1045
Range on HMM: 8-283/297.0
TKTGQTGYEEQFTVLQQVTQrPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
 ... ......|  |...   . . .. .  .| .|||.. .|| .. || |..|. ||||| ...||. |..||... |. ||  .||.|. . ||| |
kllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMLCHENENDEEVCYQYWPST-QSALVIGEYNITLLNEDK--SNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKR-G
|||. . |.. | |.||||.. .. |. |.. .|||....  .. |. |..||.....| .  ||.|..|.|.  |   .|...| .||.. . ...  .
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

NTSIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFETY
.. ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||  ||. . ...| .| ...|.
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0051299 (Phosphotyrosine protein) phosphatases II 772-1039 1.1e-69 230.4 In-house 18-286 (288) alignment 
Range on Protein: 772-1039
Range on HMM: 18-286/288.0
SkpdtKTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
     ..|.||..|.|  |....    .... .  .| .|||.. .|| .. || |..    |. ||||| .|.||. |..||... |. ||  .||.|.
l....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmv

DDRNVTAIVMLCHENENDEEVCYQYWPStQSALVIGEYNITLLNEDKSNKYIERKFEVKNN----NTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEM
 . ||. ||||. . |.. | |.||||. .. |..|.. .|||.|.. ..|. |..||.|.     .| .. ||.|. |||   |   .|. .| .....
weqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlv

YRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
.. ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||  ||.  ....| ||
rkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 784-1047 1.1e-69 230.3 In-house 3-282 (284) alignment 
Range on Protein: 784-1047
Range on HMM: 3-282/284.0
EEQFTVLQQVTQRPD-EVTHNIASQNNDKNRSTQFLPPNNHRVPLKN-----EHPDYINAVFINGY-----KEKKAFIIAESPMFNTARNFWKMIDDRNV
||.|  |...|  .  .... .. .| .|||....|| .. || ||.     |. ||||| ...||     . ||.||..  |. ||  .||.|. . ||
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

TAIVMLCHENENDEEVCYQYWPSTQSALVIGEYNITLLNEDKSNKYIERKFEVKNNN-TGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRK-R
. ||||. . ||. | |.||||.... |..|.. .|||.|.. . |. |..|..|.. ||    ||.|..|.|   |   .|. .| ..... . ...  
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFETYSN
|.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||  ||.  ....| || .. |. .
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
0040438 (Phosphotyrosine protein) phosphatases II 781-1046 2.1e-67 223.0 In-house 18-283 (317) alignment 
Range on Protein: 781-1046
Range on HMM: 18-283/317.0
TGYEEQFTVLQQVtqRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIV
|. .|.|  |...   .|. .. .  .| ||||.. .||  . || |...      ||||| ...|...|..||.. .|. ||  .||.|. . .|| ||
talleefedllsl..kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLCHENENDEEVCYQYWPStQSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRkRGNTSIV
||... |.. | |.||||. .. |..|.. .|||.|.. . .. |..||...... .  ||.|. |.|.  |  ..|...| ..|.. . .. .... ..
mLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvl

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFETYS
||||. |||...|.|| . .. ...|| .||....|  | |.||.|||  ||. . ...| ||  ..|. 
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltle
0045450 (Phosphotyrosine protein) phosphatases II 773-1039 1.1e-66 221.0 In-house 19-304 (307) alignment 
Range on Protein: 773-1039
Range on HMM: 19-304/307.0
KPDTKTGQTGYEEQFTVLQQVTQR-PDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKN-----EHPDYINAVFI--------NGYKEKKAFIIAESPMFN
. ..... ||....|  |..|| . ..| ..    .| ||||.. .|| ...|| |..     |. ||||| ..        .||. |..||.. .|. .
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSALVIGEYNITLLNEDKSNKYIERKFEVKNN-NTGAKQSVTQFQITNWDSTGEVKNPQTIL
|  .||.|. . .||.||||... |.. | |.||||.... |..|.. .|||.|.. ..|. |..||...  ||    ||.|. |.|  .|  ......|
tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeell

LIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
 .|||. . ...  ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||.  ||.   ...| .|
dfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPRD_pd Subfamily PTPRD 805-1045 1.1e-66 220.6 In-house 45-287 (564) alignment 
Range on Protein: 805-1045
Range on HMM: 45-287/564.0
ASQNNDKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQsAL
...|  |||  . .. .. || |.    .|  ||||| ||.||...||.| .  |. .| ..||.|. ..|.. |||| . .|.... | .|||...   
kpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.te

VIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
 .||. .|| .| . ..|. |.|..|....  .. |.||. |.| ..|  ......| .|... ... ....  ||||||  |||. .|..    ... |
tygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerik

TEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFETY
.|...|..|..|  | |..  |||  ||. .....| .|....| 
eektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 778-1047 2.5e-66 218.4 In-house 12-301 (301) alignment 
Range on Protein: 778-1047
Range on HMM: 12-301/301.0
TGQTGYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
. ....|||.. |....... .|... . .. ....... .. |.  .  |      . .|||| .|.||.|||.||.|..|| .| ..||..| .  ..
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

AIVMLCHENENDEEVCYQYWPSTQ-SALVIGEYNITLLNE----------------DKS-NKYIERKFEVKNNNtgAKQSVTQFQITNWDSTGEVKNPQT
.|||.. ..|. .. |.||||... .    |. ..|| ||                | | |.||||||.||...  . ..|.|.|.|.|   | |..|.|
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprt

ILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFETYSN
.| .|...  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.|. ||  .....  ||.  .||.|
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
DSPc_SM00195 784-1039 2.2e-65 216.0 In-house 3-262 (263) alignment 
Range on Protein: 784-1039
Range on HMM: 3-262/263.0
EEQFTVLQQVTQRPdEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
.|.|. |.. |.   |.|... ..|..|||....|| .. || ||.|.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

HENENDEEVCYQYWPST-QSALVIGEYNITLLNEDKSN-KYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRgNTSIVV
 |.||..| |..|||.. ..  ..|.....| ...| . ..| |..|......  ...|||.|..||   |  .... .| ...... ....  .. |||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivV

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
|||. |||...|... . ..|...|  .|.|...|. | |.||.|||  ||. . ...|.|.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 784-1039 2.2e-65 216.0 In-house 3-262 (263) alignment 
Range on Protein: 784-1039
Range on HMM: 3-262/263.0
EEQFTVLQQVTQRPdEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
.|.|. |.. |.   |.|... ..|..|||....|| .. || ||.|.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

HENENDEEVCYQYWPST-QSALVIGEYNITLLNEDKSN-KYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRgNTSIVV
 |.||..| |..|||.. ..  ..|.....| ...| . ..| |..|......  ...|||.|..||   |  .... .| ...... ....  .. |||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivV

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
|||. |||...|... . ..|...|  .|.|...|. | |.||.|||  ||. . ...|.|.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 778-1047 1e-63 210.3 In-house 17-288 (318) alignment 
Range on Protein: 778-1047
Range on HMM: 17-288/318.0
TGQTGYEEQFTVLQQVTQRPDEvTHNIASQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
.|.. ..|..  |..... . . .. . . |. ||| .  |. .. || |..    |  ||||| .|.||..|||.| | .|. .| ..||.|. ..| .
sGelllseeyerlsrseetvts.lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa

AIVMLCHENENDEEVCYQYWPSTQSAlVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRGNT
 |||| .|.|.  . . .|||| .|   .|.  ..| .| ....|. |.|.|..... ... | |...|.|  .|  ... ..| .. .  ..|.| |..
vivmltqeeergkakvhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgag

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFETYSN
 ||||||  |||  .|.|  . ... | |...||||. |  | |..  |||  ||. .....| .|.|..|. .
pivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
0039614 (Phosphotyrosine protein) phosphatases II 774-1042 1.3e-63 210.6 In-house 25-292 (297) alignment 
Range on Protein: 774-1042
Range on HMM: 25-292/297.0
PDTKTGQTGYEEQFTVLQQVTQrpDeVTHNIASQNNDKNRSTQFLPPNNHRVPLKN-----EHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMI
 ..... |.....|  |....   |  ..    .| ||||.. .|| ...|| ||      .. ||||| ...||.  ...||..  |. .|  .||.|.
lekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

DDRNVTAIVMLCHENENDEeVCYQYWPSTQSalVIGEYNITLLNEDKSNKYIERKFEVKNnnTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQ
 . .||.||||. ..|..   |.||||....  . |.. .|||.... . |. |..||.|  .|    ||.|| |.|   |   .....| ..|.. . .
weqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

RKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESF
..  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.|||  ||.  ....| .|  .
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0043336 (Phosphotyrosine protein) phosphatases II 777-1039 4.4e-63 208.7 In-house 16-277 (278) alignment 
Range on Protein: 777-1039
Range on HMM: 16-277/278.0
KTGQTGYEEQFTVLQQVTQrpDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
....|.....|  |....   |. .. .  .| ||||.. .|| ...|| |...      ||||| ...||. ...||..  |. .|  .||.|. . .|
lnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

TAIVMLCHENENDEEVCYQYWPstQSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRkRGN
| ||||. . |.. . |.||||  .. |..|.. .|||.|.. . |. |..||.|. .| .. ||... ..|   |   .....| ..... . ..   |
ttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsn

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
. ..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.|||  ||.  ....| ||
gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 808-1036 5e-63 208.0 Pfam-A 1-234 (235) alignment 
Range on Protein: 808-1036
Range on HMM: 1-234/235.0
NNDKNRSTQFLPPNNHRVPL--KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWP-STQSALVIGE
| .|||....|| .. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....|...| | |||| ...  |  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YNITLL-NED-KSNKYIERKFEVKNNNTG-AKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
....|  .|  ....|. ||.|.|....  .|..|.|...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVL
|. .||.|..|. | |.||.||.. ||. . ...|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 808-1036 5e-63 208.0 In-house 1-234 (235) alignment 
Range on Protein: 808-1036
Range on HMM: 1-234/235.0
NNDKNRSTQFLPPNNHRVPL--KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWP-STQSALVIGE
| .|||....|| .. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....|...| | |||| ...  |  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YNITLL-NED-KSNKYIERKFEVKNNNTG-AKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
....|  .|  ....|. ||.|.|....  .|..|.|...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVL
|. .||.|..|. | |.||.||.. ||. . ...|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 780-1036 1.7e-62 205.9 In-house 5-263 (283) alignment 
Range on Protein: 780-1036
Range on HMM: 5-263/283.0
QTGYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEHPDYINAVFIN---GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIV
..... .. ||....  . ... . |..|. |||  . .| ...|| ||.| .||||||||     ||..| .||| ||. .| ..||||. |...||||
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLCHENENDEEVCYQYWPSTQSaLVIGEYNITLLNEDKSNKYIERKFEVKNN-NTGAKQSVTQFQITNWDSTGEVKnPQTILLIIEEMYRTQRKRGNTSI
|| .  |. .. | ||||.  |    ||. .|| .|  || .| ... ...|  . ..  .. .|. .| . ||   .   |. .. .   |..  .. |
mltklqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqa.iinslvkfnkvislqteskkgPi

VVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVL
||||| ..||.|.|.||...... .|| |.|||.|.|  | |... |||  ||. . ..||
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_PTPRD_pd Subfamily PTPRD 649-831 1.3e-61 203.9 In-house 178-361 (564) alignment 
Range on Protein: 649-831
Range on HMM: 178-361/564.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAV
...|.||||||||||||.|||.|.. |....  .|..||..|||||||||||||..||. |.....|. .|| ......|.||  |.|| .||||. .|.
eVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheai

LESVTCGNTQVDSRNARIVFNRMSKPDTKTGQTGYEEQFTVLQ-QVTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEH
|| ..||||.|.|.| .  ...... ...|..||.|  |  |.  . . ..| .    ..|..||| .. |. .. || |....
lealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsair
0045098 (Phosphotyrosine protein) phosphatases II 791-1041 3.7e-61 202.3 In-house 16-274 (278) alignment 
Range on Protein: 791-1041
Range on HMM: 16-274/278.0
QQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPlknehpDYINAVFINGYkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCY
. ..  |.|.|...   | |||| ...|| .. ||       ||||| .|.||  .|.||..  |. .|. .||.|. . ..|.||||... |.. | |.
llllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

QYWPStQSALVIGEYNITLLNEDKSNKYIERKFEVKNN----NTGAKQSVTQFQITNWDSTGEVKNP--QTILLIIEEMYRTQR------------KRGN
||||. .. |..|.. .|||.|.  ..|. |...| |     ... .  ||......|.  |   .|  . .| ..|.. . ..              ..
qywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

TSIVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTILQYQGMFQIVLAYLES
. ..||||  |||.....|| . .  .  ||..|.....|  | |.|| .||.  ||. ... .| .|. 
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 806-1047 2.5e-60 198.8 In-house 7-250 (250) alignment 
Range on Protein: 806-1047
Range on HMM: 7-250/250.0
SQNNDKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEvCYQYWPSTQsALV
 ||..||| ..... .. || |..|.     |||||.|..||.|.||||.. .|. .|  .||.|. ......||||   .|.... . ||||  . |  
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.aek

IGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 |.  ..||....   |. ||. . ...   .. | |.. ..|   |  .. ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |.
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFETYSN
| |.|||.|.|  |...|..|..  ||  ...|.| .|.|.| |..
ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 776-1044 1.1e-58 193.8 In-house 18-288 (319) alignment 
Range on Protein: 776-1044
Range on HMM: 18-288/319.0
TKTGQTGYEEQFTVLQQVTQRpdEVTHNIASQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 .||.|. |..|  |.. ..   ....    .|..||| .. |. .. || |..    |  ||||| ||.||.|...|| . .|. ||  .||.|. ...
astgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeee

VTAIVMLCHENENDEEVCYQYWPSTQsALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGA-KQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKR
.  .|||.. .|. .  . .|||...   . |.. .||..|.. ..|| ||........     .|..|| |.|   .  .. ...| ..... ....| 
ssivvmltklveklkvklkkywpeen.feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFET
 .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||.  ||. .....|...|...|
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
0042113 (Phosphotyrosine protein) phosphatases II 805-1039 1.7e-58 193.3 In-house 6-243 (245) alignment 
Range on Protein: 805-1039
Range on HMM: 6-243/245.0
ASQNNDKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPStQSAL
   | ||||....|| .. || |...      ||||| ...||. .. ||..  |. .|  .||.|. . ..|.||||. | |.. . |.||||. .. |
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

VIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
..|.. .|||.|.. ..|. |..||.|. .. .. |.... ..|.  |.  .....| ..|.. . ... .|. ..||||. |||...|.|| . ..  .
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqle

TEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
.|. .......|  | |.||.|||  ||. . ...| .|
kelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 800-1038 2.2e-58 193.1 In-house 3-245 (249) alignment 
Range on Protein: 800-1038
Range on HMM: 3-245/249.0
VTHNIASQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPS
... .   | ||||.. .||....|| |.     .. ||||| .|.||. |..||..  |. .|  .||.|. . ..|.||||... |.. | |.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

tQSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAAT
 .. |..|.. .|||.......|. |..|..|. .| .  |...|.|.|  .|  ......| .||..   ...   .. ..||||. |||...|.|| .
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAY
 ..  ..|. .|.....|  | |.||.||.  ||.   ...| .
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPRA_pd Subfamily PTPRA 806-1039 2.2e-56 186.1 In-house 56-295 (330) alignment 
Range on Protein: 806-1039
Range on HMM: 56-295/330.0
SQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPStQSALV
 .|..|||  . || .  || | .    |. ||||| ||.|||||. || |  |  .|  .||.|| ... ..|||| . .| .|| |.||||. . .. 
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd.eGlvt

IGEYNITLLNEDKSNKYIERKFEVKNN----NTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTIN
 |. .... .|  ...|  ||| |..     .  ... |.||  | |   |   .|. .| ..... ..... .. .||||||  |||.  |..  . ..
yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavle

KCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
. |.|...|||...|. | |.|  |||  ||. .....| | 
rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 645-761 1.5e-55 183.2 In-house 170-287 (287) alignment 
Range on Protein: 645-761
Range on HMM: 170-287/287.0
QPPLMITQYHFTSWPDHG-VPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIF
.......||..|.|...| |.|..|..|......|...|.......||||..|||...|.|..........||.||........|.|.....||..||.|
gdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykf

VNDAVLESVTCGNTQVDS
.||.|||......|..|.
indivleyldsfetysdf
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 775-1041 1.3e-53 177.0 In-house 9-278 (281) alignment 
Range on Protein: 775-1041
Range on HMM: 9-278/281.0
DTKTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNHRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDR
 ..  ..|. |... |... .. .  |   | .|  ||| .     .. || .    .|.. ||||| |..|||..|..|....|. ..  .||.|. ..
lsqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

NVTAIVMLCHENENDEEVCYQYWPSTQSALVIGEYNITLLNEDKSNKYIERKFEVkNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKR
.|.||||. .| |..   |..|||  .|.| .|.. .. ..| ....||||||.. ....| ...|.|.. |.|  .|  .... .|   .|......|.
kvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekk

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLES
 ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||..||. ....|| .|. 
tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Ptp69D_pd Subfamily Ptp69D 778-1041 6.8e-53 174.8 In-house 19-288 (307) alignment 
Range on Protein: 778-1041
Range on HMM: 19-288/307.0
TGQTGYEEQFTVLQQVtQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
  . |... .  |..  . . . .      |. |||. .  . ...|| ||    .|. ||||| ||.|||||| ||.|  |. .|. .||.|| . .||
dtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

AIVMLCHENENDEEVCYQYWPSTqSALVIGEYNITLLNEDKSNKYIERKFEVKNNN-----TGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQR
 ||||  ..| ... | .|||        |. ...| .|.| ..||.|...| ...       ... |.|.. |.|. .   . ....| .||...  ..
livmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyk

KRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLES
.  .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  || . ||. ... .| | . 
ln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPRG_pd Subfamily PTPRG 778-1044 7e-53 174.7 In-house 16-292 (563) alignment 
Range on Protein: 778-1044
Range on HMM: 16-292/563.0
TGQTGYEEQFT-VLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKN-----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 |..|..|.|  . ......  ...|  . .|  ||| .. .. .. || |..     .. ||||| .|.||. .||||..  |. .|.  ||.|| ..|
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

VTAIVMLCHENENDEEVCYQYWPStQSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAK------QSVTQFQITNWDSTGEVKNPQTILLIIEEMYR
|. |||.   .|.  . | .|||. . .. .|. ..|| .|..   | .|.. .|| .  .|      . |.|.. |.|  .|  . .   |  ..   .
vaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssa

TQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFET
....     ||||||  |||. ....  | ... ..| ...||..||  | |..  |||. ||. .....|  . | ||
anka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 776-1039 7.5e-53 174.4 In-house 16-279 (288) alignment 
Range on Protein: 776-1039
Range on HMM: 16-279/288.0
TKTGQTGYEEQFTVLQQVTqRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 ....||..|.. .| ..  . ..||    ..|..|||  . || . .|| ||.    .  ||||| .|.|.|.||..| . .|. .|  .||... ...
sarnrtgfseeynsLaale.ktksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

VTAIVMLCHENENDEEVCYQYWPSTQSALVIGEYNITLLNEDKSNKYIERKFEVKnnNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRg
.. |||| .  |.... | .|||...     |. ..||... . .....||....   .. .  .||.| . |  .|  .. . .| ... .  .. .  
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
   |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||  ||. .....|   
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPRB_pd Subfamily PTPRB 776-1041 4.1e-52 172.0 In-house 20-287 (293) alignment 
Range on Protein: 776-1041
Range on HMM: 20-287/293.0
TKTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNHRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
..  .... |..  |..| .   .|. . ...|..||| |. || .. || |    .... ||||| .|.||. .. || .  |. .|  .||.|. ...
kadsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekk

VTAIVMLCHENENDEEVCYQYWPSTQSALVIGEYNITLLNEDKSNKYIERKFEVKNnnTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQ-RKR
...|||| .  |.  . | .|||..... . |. ..||..|.. .... |......  . ....|.|.. | |   |  ....|.| ..... ... .. 
ssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiekta

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLES
 .. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||  ||  . | ||..|..
skrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPN23_pd Subfamily PTPN23 777-1040 2.9e-51 169.0 In-house 11-281 (288) alignment 
Range on Protein: 777-1040
Range on HMM: 11-281/288.0
KTGQTGYEEQFTVLQQVTQRP-DEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTA
  |.|. ...|  |.|  ..   . .  ||  . .||||.  || .. || |.... ||||| |...       ||.. .|. .|.  ||.|. .. .  
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLCHENENDEEVCYQYWPSTQ-SALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEE---MYRTQRKR
|||| ...| ... . .|||. .  . . |....|| .. ......||..... ... |..||.  |.|.| . |  . |.|.| ...|   .|......
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrk

GNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLE
 .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||.  |.. ....|| . .
sktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 649-773 5.8e-51 168.4 In-house 179-304 (305) alignment 
Range on Protein: 649-773
Range on HMM: 179-304/305.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDA
 ..||..|.|||||||..|||.|.. .|.....|  || |.||||||||||||.|.|.|. |....||. .|.  .....|..||||.|| ||| |. ||
tvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhda

VLESVTCGNTQVDSRNARIVFNRMSK
. | .|||.|..   | |.  |.. |
ldelitcgdtsiigsnlrarvnklkk
0037934 (Phosphotyrosine protein) phosphatases II 805-1037 1.4e-50 167.5 In-house 7-240 (243) alignment 
Range on Protein: 805-1037
Range on HMM: 7-240/243.0
ASQNNDKNRSTQFLPPNNHRVPLKNehPDYINAVFINGYKeKkaFIIAESPMFNTARN----FWKMIDDRNVTAIVMLCHENENDEEVCYQYWPstQSAl
  .| .||| . .|| .. || |..   ||||| .|.... .  .|.   |. .|  .    ||.|. . ..|.||||... |.. | |.||||  ..  
lpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.

VIGEYNITLLNEDKSNKYIERKFEVKNNN-TGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCAA
..|.. .|||.|   ..|. |.....| . .. .. |.... ..|   |   .|. .| ...|..  ...        ..  ..||||  |||.....||
tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaa

ATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTILQYQGMFQIVLA
 . . ..   | .|.....|  | |.|| .|||  ||.   ...| 
ylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN12_pd Subfamily PTPN12 776-1040 3.4e-50 165.6 In-house 3-278 (290) alignment 
Range on Protein: 776-1040
Range on HMM: 3-278/290.0
TKTGQTGYEEQFTVLQQVTQRP--DE---VTHNIASQNNDKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKM
 |.|.  ....|. |......   ..    ..  ...|  |||    || .. || |.    .|. ||||| ||.| ..|...| | .|. .|  .||.|
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

IDDRNVTAIVMLCHENENDEEVCYQYWPST-QSALVIGEYNITLLNEDKSN-KYIERKFEVKNNntGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMY
|.. ||. .||.|.| |..   | .|||.. ...| .||...|| .|.. .  .. | ..|...  .....|.||. |.|   |  ......| .||.. 
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvr

RTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLE
..|. . .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  |||  ||. ... |. ...
elqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPRK_pd Subfamily PTPRK 806-1037 1.5e-49 163.6 In-house 41-275 (314) alignment 
Range on Protein: 806-1037
Range on HMM: 41-275/314.0
SQNNDKNRSTQFLPPNNHRVPLKN---E-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSAlv
 .|..||||.. |.....|| |.    . . ||||| .|..||  .|||..  |. .| ..||... | | ..|||| .  |.    |..|||   .   
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..

IGEYNITLLNEDKSNKYIERKFEVKN--NNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKC
 |. ...|.. .  .... | | |..   .  ... | ||| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||. .|.| .. ..  
ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmi

KTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLA
..|||.|||.. |. | .|.  |.|  ||. .....| 
eregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPN6_pd Subfamily PTPN6 769-1043 3.3e-49 162.6 In-house 14-301 (306) alignment 
Range on Protein: 769-1043
Range on HMM: 14-301/306.0
NRMSKPDTKTGQTGYEEQFTVLQQVTQ-RPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNE---HPDYINAVFINGY--KEKKAFIIAESPMFNTARN
....| .......|.||.|  |||  . .  . ..    .|. |||    || .. || ||..     ||||| .|..   ...|..| ..  . .|  .
selekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsd

FWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSALVIGEYNITLLNEDKSNKYIERKFEVK-NNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIE
||.|. . | . |||. .|.|  .| |..|||....    |....| ..|.. ..|| |.. |. ... . ...| |.. ..|   |  |.|...|  .|
FWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfle

EMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFE
.. | |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | |||  ||. ..... .|.|. .
dvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 804-1040 2.2e-48 159.7 In-house 40-278 (315) alignment 
Range on Protein: 804-1040
Range on HMM: 40-278/315.0
IASQNNDKNRSTQFLPPNNHRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSA
  ..|  |||    || .. || |    .. . ||||| .|..... ||.| .  |   .  .||.|. . .||.|||. . .|.|   | ||||  .. 
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

L-VIGEYNITLLNEDKSNKYIERKFEVKNNNtgAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINK
.   |.....||. .     . ||. ... .  ... ||||| |.|   |  |.  ..| .| |.    ... . |..||||  |||. .....   ...
svefGsikvellsleadtdgvarklvtrkse..esrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaq

CKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLE
 | . ..|||...|  | ..|  |||  .|  ....|| .| 
ikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 794-1044 1.1e-47 157.6 In-house 39-289 (297) alignment 
Range on Protein: 794-1044
Range on HMM: 39-289/297.0
TQRPDEVTHNiaSQNNDKNRSTQFLPPNNHRVPLK--NEH--PDYINAVFINGYKEkkAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEeVC
. .|. |...    | .|.| .  || .  || |.  |..   ||.|| |..|.|.   .|  . || .|  .||.|. | .|..|||| ..||.|.  |
niqpqtvaek..kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kc

YQYWPSTQSALvIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVK--NPQTILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSA
 .||. . ..   |.  ..||  .. . .|.|..||..... |.. | |.| ..| .  . .  . ...| .|.|.  .  .. .. ..|||.  ||| .
aryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESFET
....    . . | |  .|.|...|  | ..|  |||  ||. ....|| .| | .|
vlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 773-1036 3.2e-47 156.4 In-house 26-288 (319) alignment 
Range on Protein: 773-1036
Range on HMM: 26-288/319.0
KPDTKTGQTGYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMID
| | .  .| .| .|  . ...    . |.    || |||| .. |. .. .| |..    |  ||||| |..||. |. .| |  |. ||  .||.|| 
ksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiw

DRNVTAIVMLChenendEEVCYQYWPSTqSALVIGEYNITLLNEDKSNKYIERKFEVKN-NNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEE-MYRT
. |...||.|       .. | ||||        ..... .   .....|. |..|. .  .   ....||| .  |   |  . |  .. ...   . |
eyncstivllt......kdkcsqywplk.ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlt

QRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVL
........||||||  |||. .. .  . ... | |  .||.....  | |..  || . ||. ..  .|
skenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 777-1040 8.4e-47 154.4 In-house 13-277 (515) alignment 
Range on Protein: 777-1040
Range on HMM: 13-277/515.0
KTGQT-GYEEQFTVLQQVTQRPDEVTHNiaSQNNDKNRSTQFLPPNNHRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
| ..|  . |.|  |      |. |. .    |  |||    || .. || |     | | ||.|| .|....  ||.| .  |   .  .||... . |
knrhttlfseefhdlpgpniypqtvaqe..einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqen

VTAIVMLCHENENDEEVCYQYWPS-TQSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTgaKQSVTQFQITNWDSTGEVKNPQTILLIIEEMyRTQRKR
||.|.|. . .|.|   | .|||     ..  |.... |.  .     | ||..|  ..    . ||||. |.|   |  |. ...| .| |. .... .
vttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikev.kadhgq

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLE
 . ....|||  |||  .....   . . ||  ..|||....  | ..|  |||  ||  ....|| .| 
ythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 799-1036 1e-46 154.7 In-house 16-252 (284) alignment 
Range on Protein: 799-1036
Range on HMM: 16-252/284.0
EVTHNIASQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenendEEVCYQYWP
. |.    || |||| .. |. .. .| |..    |  ||||| ||.||. |. .| .  |. ||  .||.|| . |...||.|       .. | ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

STqSALVIGEYNITLLNEDKSNKYIERKFEVKN-NNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAA
        ..... .   ..|..|. |..|. .  .   .....|| .  |   |  . |  .. ...   . |........||||||  |||. .. . 
lk.ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

ATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVL
 . ... | |  .||.....  | |..  || . ||. ..  .|
dvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 779-1039 3.4e-46 152.9 In-house 21-288 (325) alignment 
Range on Protein: 779-1039
Range on HMM: 21-288/325.0
GQTGYEEQFTVLQQVTQRPdeVTHNIASQNNDKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNvTA
 | |.  .| .|  .       .     .| .|||    .. .. || |.    . . ||||| ... .|.|. |. | .|. .|  ..|... | . ..
dqdgfahefgllpsddgia..kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.cs

IVMLCHENENDEEVCYQYWPST-QSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEM---YRTQR--
.|..  | ..... | .|||     .   |  .. |   ..   |. |...||. . |  .|| |||.  ||  |  | | |.. |.. .     . .  
vvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan

KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
 .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.|. ||  ... .  ..
tkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 649-787 7.2e-46 151.7 In-house 179-318 (319) alignment 
Range on Protein: 649-787
Range on HMM: 179-318/319.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDA
.......|.||||.|||.|||.|.. .||..  . ...||. |||||||||||||...|. |.. ..|| .|. |...|.| ||  |.|. .||.|. .|
evkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyea

VLESVTCGNTQVDSRNARIVFNRMSKPDTKTGQTGYEEQF
.|| |..|.|... .. |  . .... ...||.|| | .|
lleaveagdteievqdlrdrlkqlaekvadtgetgleref
0051299 (Phosphotyrosine protein) phosphatases II 586-751 1.3e-45 151.5 In-house 3-285 (288) alignment 
Range on Protein: 586-751
Range on HMM: 3-285/288.0
NLIPVEQFGEFVANGHAKGNEGFRNQFMMLDRGESEHIVTVGLSPSNKLLNRFANIV-------------------------------------------
. |.||.. ..| . .|.|. |....| .| .    . ....| | |.  ||. .|.                                           
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

--------------------------------------------------------------------------VYQPPLMITQYHFTSWPDHGVPEYAT
                                                                            . ....|..|.|.|||||||....
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

SILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLES
..|.| |.... .....||..||||||||||||| |.|. |.| |||||.|. ....|.|.||. |.|| .||.|| .|.|| 
llldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0040438 (Phosphotyrosine protein) phosphatases II 591-787 3.7e-45 149.9 In-house 3-311 (317) alignment 
Range on Protein: 591-787
Range on HMM: 3-311/317.0
EQFGEFVANGHAKGNEGFRNQFMMLDRGESEhIVTVGLSPSNKLLNRFANIVVYQ---------------------------------------------
... ...   ..... .....|..|..   .   .|.. | || .||. .|. |                                              
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

--------------------------------------------------------------------PPLMITQYHFTSWPDHGVPEYATSILQFHRRI
                                                                    .....|..|.|.|||||||.. ...|.| ...
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

KNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSKPDTK
.. ... .||.|||||||||||||| |... |.| |||||.|. ......|.||....|| .||.|. ||.|| .....| ..  .    . ..  |.. 
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplal

TGQTGYEEQF
.. ...|...
ddvklkekel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 806-1037 3.7e-45 149.2 In-house 47-277 (315) alignment 
Range on Protein: 806-1037
Range on HMM: 47-277/315.0
SQNNDKNRSTQFLPPNNHRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTqsALV
..| .|||  . .. .. || |    ...| ||.|| ||.||. |. .| |..|  .. ..||... . ... ||||    |.... . .|||     ..
ienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kvi

IGEYNITLLNEDKSNKYIERKFEVKNNNtgAKQSVTQFQITNWDsTGEVKNPQTILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 |.. .|. .|.. ..|  | . |  ..    . | |...| |  . .| .  . |. .    .  ..   ..||||||. |||.  |..  . ... ..
yGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaea

EGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLA
| .|||.....  | .. . ||.. ||| .....| 
enaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPN3_pd Subfamily PTPN3 801-1037 1.2e-44 147.3 In-house 34-273 (280) alignment 
Range on Protein: 801-1037
Range on HMM: 34-273/280.0
THNIASQNNDKNRSTQFLPPNNHRVPLKNEHPDYINAVFIN----GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPST
..   ..| .|||    || .. || ||... ||||| ..|    . .  . .|..  |. .|| .||.|. ..... ||||    |.    |.||||.|
saarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPet

QSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTI
.  |  ||..... .||....|. |.. .|...|  .....|.| ..|   |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  |..
edeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletal

NKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLA
 .  ..  . . ....  | |.   |||  ||. . . .|.
alieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 649-788 3.5e-44 146.2 In-house 176-316 (318) alignment 
Range on Protein: 649-788
Range on HMM: 176-316/318.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDA
.. |||.|||||.|||| ..|.|.. |....   |...||..|||||||||||.|.|.|. |.....|. .|.  .....|.||  |.|| |||.|. |.
qvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydv

VLESVTCGNTQVDSRNARIVFNRMSKPDTKTGQTGYEEQFT
.|| ...|.|.||... |   ... ..|...|.|  . .| 
llealasgdtevdasdlrsrirelreqdpesgttemdaefq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 806-1041 3.5e-44 145.9 In-house 26-270 (274) alignment 
Range on Protein: 806-1041
Range on HMM: 26-270/274.0
SQNNDKNRSTQFLPPNNHRVPLKN-----EHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSA
. .. ||| .. || .| || |..     |  .|||| .| ||.| .||.. .  |. ||  .||.||  ..|. |||| . .|..|. | .|.| ....
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

LVIGEY---NITLLNEDKSNKYIERKFEVKNNNTgaKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAAT
 . ..|   .|.  .  . |.|  ||. .|. .   ..||. .  |.|  .   ....|.| ...|. ...... .   ..|||||  .||  .| |.  
eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLES
.... . |.|.||...    |... | |||  ||. .....  ||. 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPN9_pd Subfamily PTPN9 778-1039 5.4e-44 145.4 In-house 13-290 (297) alignment 
Range on Protein: 778-1039
Range on HMM: 13-290/297.0
TGQTGYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
.|. |  .... ... .    ....     |  ||| |  |  .. || |..    |. ||||| |..|||.||||| .  |. .| ..||.|. ...| 
kgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevl

AIVMLCHENENDEEVCYQYWP-STQSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQR----
 |||  .  |.    | |||| ...|.   |..... .. .....| .|..|.|| .|. ...|| ||.. |   |  .. ...| ..|.. ..|     
vivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavk

-----KRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
     ..|   .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.||  ||.  .. || | 
elgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 647-757 8e-44 144.6 In-house 177-288 (290) alignment 
Range on Protein: 647-757
Range on HMM: 177-288/290.0
PLMITQYHFTSWPDHG-VPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVN
. ..|||..|.|...| |....|..|......|...|.......||||..|||...|.|..........||.||........|.|.....||..|| ...
kqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgif

DAVLESVTCGNT
. ||..... .|
qivltyldsfet
0050432 (Phosphotyrosine protein) phosphatases II 590-756 1.3e-43 144.9 In-house 28-303 (308) alignment 
Range on Protein: 590-756
Range on HMM: 28-303/308.0
VEQFGEFVANghAKGNEGFRNQFMMLDRGESEHIVTVGLSPSNKLLNRFANIVVY---------------------------------------------
|... ... .  |... ... .|. | .    .  .|.| | || .||. .|. |                                             
vldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFw

--------------------------------------------------------------------QPPLMITQYHFTSWPDHGVPEYATSILQFHRR
                                                                    .. ...|..|.|.|||||||......|.| ..
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

IKNEYkpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLESVTCGN
... .   .||..||||||||||||| |.|. |.| |||||.|. ......|.||. |.|| .||.|. .|.|| . .  
vrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 782-1035 6.9e-43 141.6 In-house 7-255 (267) alignment 
Range on Protein: 782-1035
Range on HMM: 7-255/267.0
GYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHE
 .|..|  ......    ..  ||..|...||  . || .. ||.|...  .|||| ...||| |.|||. . |. ||  .|...| |..|. ||.| . 
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv

NENdeEVCyQYWPST-QSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKqSVTQFQITNWDSTGEVKNPQTILLIIeeMYRTQRKRGNTSIVVHCS
 ..  ..  ..||     |    .  .    | . | |    .|.| .|  |.  || .   .|.   . |     |. |  . . | . ||  .||.||
ftd..nir.lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesah.nvtlyyykkwnintnnkpylkplfgi..laknqlengnrPlvvacs

DTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIV
| ||||  |  . . ... ||||| |.|. |.  | |..| |.|  .|  . ...
dGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_PTPN13_pd Subfamily PTPN13 783-1041 8.4e-43 141.6 In-house 13-271 (273) alignment 
Range on Protein: 783-1041
Range on HMM: 13-271/273.0
YEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEHPdYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
 .|.|. |...    |...     .|.||||  . || .. ||.|..| . |||| .|.    |..  .|..  |. .|...||.|. ..... |.|. .
Paeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

ENENDEEVCYQYWPSTQS-ALVI-GEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRkrGNTSIVVH
| |...  | .|||....  |.. . ....||.  | . .  |...||....|. . |.... ..|   |  .... .| .. |. | |.   .. ||||
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvh

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLES
||  .||| .. .  . ..  . .  .|| ..... | |. | |||  ||  .....|  |.|
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
0043336 (Phosphotyrosine protein) phosphatases II 588-750 2.3e-42 140.7 In-house 2-275 (278) alignment 
Range on Protein: 588-750
Range on HMM: 2-275/278.0
IPVEQFGEFVANGHAKGNEGFRNQFMMLDRGESeHIVTVGLSPSNKLLNRFANIV---------------------------------------------
|.|... ..... ..... .....|  |..       ...|.| || .||. .|.                                             
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

-------------------------------------------------------------------VYQPPLMITQYHFTSWPDHGVPEYATSILQFHR
                                                                    . .....|.||...||||||||  ...|.| .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

RIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLE
.... ... .||.||||||||||||||.|... |.|.|||||.|. ......|.||....|| .||.|. .|.||
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_CG7180_pd Subfamily CG7180 796-1039 6.4e-42 138.2 In-house 30-290 (296) alignment 
Range on Protein: 796-1039
Range on HMM: 30-290/296.0
RPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEeVCYQ
. ..  ... ..| .|||  . .|... || |.    .|. ||||||.....  ||..|. | |. .|  .||... |... |.|.|... .  .  . .
eigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myps

YWPSTQsALVIGEYNITLLNEDKSNKYIERKFEVKNN-------NTGA---KQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRG-----NTSIV
||| ..     ||  . ...|..  .   |.| .. .       ...    .  |..||.| |..  .|    . |. . .. |. |..      .  .|
ywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
|..|| ..|| ...|.  .... . |. .|||. .|  |...|. |... .|. .....| ..
vvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0039614 (Phosphotyrosine protein) phosphatases II 586-755 7.9e-42 139.1 In-house 12-292 (297) alignment 
Range on Protein: 586-755
Range on HMM: 12-292/297.0
NLIPVEQFGEFVANGHAKGNEGFRNQFMMLDRGESEhiVTVGLSPSNKLLNRFANIVVY-----------------------------------------
 .||.. .  ..   .|... .....|..| .   .   ...|.| || .||. .|. |                                         
ipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP

----------------------------------------------------------------------QPPLMITQYHFTSWPDHGVPEYATSILQFH
                                                                      ......|....|.|||||||......|.| 
lpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllefl

RRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLESVTCG
. ... ..  | .||.|||||||||||||| |... |.| |||||.|. ......|.||....|| .||.|. ||.|| . ..
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0047943 (Phosphotyrosine protein) phosphatases II 601-750 1.2e-41 138.4 In-house 7-270 (273) alignment 
Range on Protein: 601-750
Range on HMM: 7-270/273.0
HAKGNEGFRNQFMMLDRGESEHIVTVGLSPSNKLLNRFANIVV---------------------------------------------------------
...|. ... .| .| .   ..  .|.| | || .||. .|.                                                          
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

-------------------------------------------------------YQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP--TKG
                                                       .. ....|..|.|.|||||||.. .|.|.| . ... ..    .|
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLE
|..||||||||||||| |.|. |.| |||||.|. ......|.||. |.|| .||.|. .|.||
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_PTPRK_pd Subfamily PTPRK 645-787 1.3e-41 137.4 In-house 170-312 (314) alignment 
Range on Protein: 645-787
Range on HMM: 170-312/314.0
QPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFV
.   .. |..|..||||.|| .||..|.. ||.|.  ....|...|||||| ||||||.|||. |. .|.|| .|.  ..  .|.... |..| .||.|.
eeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfi

NDAVLESVTCGNTQVDSRNARIVFNRMSKPDTKTGQTGYEEQF
 |..||.. ||.| .   . . ..  ... |..|  .  .|.|
ydvileaclcgetaipvsefkalylesirldpqtnssqlkeef
subfamily_PTPRB_pd Subfamily PTPRB 649-753 3.2e-41 136.3 In-house 180-286 (293) alignment 
Range on Protein: 649-753
Range on HMM: 180-286/293.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVND
 ..|||||||||||||| ....|.| |.....   . .|.|..|||||||||||||.|.|. ||. |.|  .||..|. ..|..|. ..|| .||||...
kvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihq

AVLESVT
.||. ..
cvldllr
0036941 (Phosphotyrosine protein) phosphatases II 602-758 3.5e-41 136.8 In-house 9-283 (297) alignment 
Range on Protein: 602-758
Range on HMM: 9-283/297.0
AKGNEGFRNQFMMLDRGESEHIVTVGLSPSNKLLNRFANIVV----------------------------------------------------------
.... ... .|. |..       .|.|.| |. .||. .|.                                                           
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

-------------------------------------------------------YQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKG
                                                       .......|..|.|.||||||||...|.|.| ..... .|  | .|
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

PMLVHCSAGVGRTGTFMAIDMGLQQAE---KEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLESVTCGNTQ
|.||||||||||.||| |.|. ||| |   ||||.|| .... .|.||. ..|| .||.|. .|.|| . ...| 
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0046845 (Phosphotyrosine protein) phosphatases II 610-757 8e-41 135.7 In-house 4-279 (284) alignment 
Range on Protein: 610-757
Range on HMM: 4-279/284.0
NQFMMLDRGESEH--IVTVGLSPSNKLLNRFANIVV----------------------------------------------------------------
 .|..| .    .   ..|.| | |. .||. .|..                                                                
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

---------------------------------------------------------YQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PT
                                                          ......|..|.|||||||||......|.| | ... ..  |.
vIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

KGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---GIDIISIINRMRQQRMKMIQTADQYIFVNDAVLESVTCGNT
.||..||||||||||||| |.|. |.| ||||   |.|. ....|.|.||. |.|| .||.|| .|.|| . ...|
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_PTPN1_pd Subfamily PTPN1 792-1035 1.2e-40 134.0 In-house 14-267 (290) alignment 
Range on Protein: 792-1035
Range on HMM: 14-267/290.0
QVTQRPDEVTHNI--ASQNNDKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVC
....  ......     .|...||     | .  |. |.... ||||| ...  . |. .|..  |. ||.  ||.|. ...  |.||| .  |...  |
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

YQYWPSTQS--ALVIG--EYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQR-KRGNTSIVVHCSDTVG
.||||. ..  .|..   .....|..|.....|. |..|..| .|   .....|  | |   |  . |.. |  . .. ..   ..     |.|||  .|
aqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIV
||  || . | .    | .    .|. .||   | .. | .||  | .  .. .
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 804-1041 2e-40 133.5 In-house 16-266 (270) alignment 
Range on Protein: 804-1041
Range on HMM: 16-266/270.0
IASQNNDKNRSTQFLPPNNHRVPLKNEHP----DYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQS
 | ...  ||... ||  . || |....      |||| ...|... ||..| | .|. .| ..||.|| ...||||||. . .|.  . | .|||. . 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

A---LVIGEYNITLLNEDKSNKYIERKFEVKnnNTGAKQSVTQFQITNWDSTGEVKNP------QTILLIIEEMYRTQRKRGN-TSIVVHCSDTVGRSAM
    |  |. ... |.| |.. || .. ...  ..| .. .. |. ..|   | ....      . .| ..... |....  . . ..||||. |||. .
ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLES
. |  ....  .... .|| ....  | ...  ||.  ||. ... |. | | 
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 807-1040 1.1e-39 131.0 In-house 37-278 (287) alignment 
Range on Protein: 807-1040
Range on HMM: 37-278/287.0
QNNDKNRSTQFLPPNNHRVPLKNEH---PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSALVIG
 .  ||| .. || .. || | .|     ||||| .. .|....||| | .|.  | |.||... .......... .| |.    ||.|||  .  . .|
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYNITLLNED-KSNKYIERKFEVKNNNTGAKQSVTQFQITNWdsTGEVKNPQTI-----LLIIEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTI
 | ..||. | |. .|  | . . . .|   . | |... .|    .|  | ..      | ...    .|.  .   .|||..  .||| .. |  . .
GysvvlldydikePeygvralrlidletrearvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

NKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLE
.. .  | .|| .|.   | .. . ||...|.. ... . .| .
srledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 650-787 1.3e-39 131.0 In-house 177-314 (315) alignment 
Range on Protein: 650-787
Range on HMM: 177-314/315.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVL
. |.|.||||| |||.|........|..|   . . |...|||||||||||||...|  |.||| |  ||.  .|...||.|.||.|.|.|| |. ||.|
vvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall

ESVTCGNTQVDSRNARIVFNRMSKPDTKTGQTGYEEQF
|.. ||.| .  .     .. .  |   || |  .|||
etfvcgdtsiaqdlylqrydsllapspdtgstllqeqf
0045450 (Phosphotyrosine protein) phosphatases II 587-750 2.4e-39 131.3 In-house 8-302 (307) alignment 
Range on Protein: 587-750
Range on HMM: 8-302/307.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDRGES--EHIVTVGLSPSNKLLNRFANIV------------------------------------------
.|.....  .|.  ......|.. .| .| . .    .  ...|.| || .||. .|.                                          
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

----------------------------------------------------------------------------------VYQPPLMITQYHFTSWPD
                                                                                    ......|..|.|.|||
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpd

HGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQRMKMIQTADQYIFVNDAVLE
||||..  ..|.| ..... .   | .||.||||||||||||||.|... |.| ||||    .|. ......|.||....|. .||.|. .|.||
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 649-759 3.1e-39 130.0 In-house 186-297 (298) alignment 
Range on Protein: 649-759
Range on HMM: 186-297/298.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKG--PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVND
.. | |||||||.||||.|||.|.. |...  ..   |  |..|.|||||||.|||.|||  |....||  .|.  .....|..|....|| .||.|. .
evrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiye

AVLESVTCGNTQV
|||| ....|...
avlealdsfndei
Y_phosphatase Protein-tyrosine phosphatase 648-750 3.5e-38 126.7 Pfam-A 133-235 (235) alignment 
Range on Protein: 648-750
Range on HMM: 133-235/235.0
LMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDA
 ...|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.|.|.|. .|. .|....|.||..|.|...||||. .|
revkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka

VLE
.||
ile
Y_phosphatase Protein-tyrosine phosphatase 648-750 3.5e-38 126.7 In-house 133-235 (235) alignment 
Range on Protein: 648-750
Range on HMM: 133-235/235.0
LMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDA
 ...|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.|.|.|. .|. .|....|.||..|.|...||||. .|
revkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka

VLE
.||
ile
DSPc_SM00195 646-751 9.3e-38 125.4 In-house 156-261 (263) alignment 
Range on Protein: 646-751
Range on HMM: 156-261/263.0
PPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVN
 .  .|||....|||||||. ..|.|.. | .|.... ..||..|||||||||||||..||. |.. |.|  .|| .|....|.||..|.|| .||.|. 
etrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiy

DAVLES
.|.|| 
eailey
PTPc_SM00194 646-751 9.3e-38 125.4 In-house 156-261 (263) alignment 
Range on Protein: 646-751
Range on HMM: 156-261/263.0
PPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVN
 .  .|||....|||||||. ..|.|.. | .|.... ..||..|||||||||||||..||. |.. |.|  .|| .|....|.||..|.|| .||.|. 
etrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiy

DAVLES
.|.|| 
eailey
subfamily_PTPN14_pd Subfamily PTPN14 792-1040 2.4e-37 123.6 In-house 31-297 (300) alignment 
Range on Protein: 792-1040
Range on HMM: 31-297/300.0
QVTQRPDEVTHNI--ASQNNDKNRSTQFLPPNNHRVPL---KNEHPDYINAVFING--YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENEN
.....  . . .     .|..|||  ..|| .. || |   |... .||||  |.     ... .|.| .|. .| ..||.|. . .|. |||| .|.|.
ripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeed

DEEVCYQYWPST---QSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRGNT--------
  | ...|.|..   .. .  |....|    ..|...| .....|   .. ...|  .| |.|   |  ..... |  .||.   .||  ..        
gkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskP

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLE
 ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. ||. ...... ||.
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0042113 (Phosphotyrosine protein) phosphatases II 634-750 2.8e-37 123.9 In-house 11-241 (245) alignment 
Range on Protein: 634-750
Range on HMM: 11-241/245.0
LLNRF-----------------------------------------------------------------------------------------------
 .||.                                                                                               
dknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdft

----------------ANIV--VYQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID
                 ...   . .......||...|||||||..  ..|.|...... .. . .||.||||||||||||||.|... |.|.|||.|..
vtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs

IISIINRMRQQRMKMIQTADQYIFVNDAVLE
. ... ..|.||....|| .||.|. .|.||
leeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPRN_pd Subfamily PTPRN 781-1035 6.7e-37 121.8 In-house 29-288 (297) alignment 
Range on Protein: 781-1035
Range on HMM: 29-288/297.0
TGYEEQFTVLQQVTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAI
.  |...  | .  . |   .   | .| .||||...|| .. || ||.    |. ||||| .|     .  |.| ...|. .|  .||.|. .. |. |
drlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

VMLCHENENDEEVCYQYWPSTQSAlVIGEYNITLLNED-KSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRGnTS
|.|.. .|.. . |..||| . |. | . |.. |. |   .. |. | | .|| .|   ..||||    | ..|   .....|     . .. | |  ..
vnltrleeegvkqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cp

IVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIV
||||||| .||. ....    .|.  |    ||.   |.  | |.|| |.|  |.. ... |
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
PTPc_DSPc_SM00012 650-750 1.8e-36 119.9 In-house 2-105 (105) alignment 
Range on Protein: 650-750
Range on HMM: 2-105/105.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK--GPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMIQTADQYIFVND
...||.|.||||||||...|||.. | .|....  .  .|..|||||||||||||.|.|. ||| ||| . .||  |....|.||..|.|| .||.|. .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
0040439 (Phosphotyrosine protein) phosphatases II 629-750 2.2e-36 121.2 In-house 8-244 (249) alignment 
Range on Protein: 629-750
Range on HMM: 8-244/249.0
SPSNKLLNRFANIV--------------------------------------------------------------------------------------
 | || .||. .|.                                                                                      
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsle

---------------------------VYQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE
                            ............|.|||||||..  ..|.| ..... ..  |..||.|||||||||||||| |... |.| |
ygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqle

KEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLE
||.|.|. .... .|.||....|. .||.|. .|.||
kelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 648-750 2.7e-36 120.1 In-house 175-277 (288) alignment 
Range on Protein: 648-750
Range on HMM: 175-277/288.0
LMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDA
| ||||....|||||||| .. .|.. | .|.  .   ||..|||||||||||||.|.|. ... |.|  ||........|.||. ..||  ||.|. ..
leitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyev

VLE
.|.
lls
subfamily_PTPRA_pd Subfamily PTPRA 648-787 4e-36 119.5 In-house 191-330 (330) alignment 
Range on Protein: 648-787
Range on HMM: 191-330/330.0
LMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDA
 ...|.||||||| |||  .  .|.. ...|.  . . ||. |||||||||||||...|  |.. . |. .|.  ...|.|.|| .|.||  || |.  .
rlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykv

VLESVTCGNTQVDSRNARIVFNRMSKPDTKTGQTGYEEQF
.||    |.|..|       .... .  |.| ..| ||.|
lleyylygdteldvsslekhlqklynkitgtdkigleeef
0045098 (Phosphotyrosine protein) phosphatases II 622-754 4.8e-36 120.0 In-house 23-274 (278) alignment 
Range on Protein: 622-754
Range on HMM: 23-274/278.0
HIVTVGLSPSNKLLNRFANIV-------------------------------------------------------------------------------
  .|..| ..|. .||. .|.                                                                               
seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdft

--------------------------VYQPPLMITQYHFTSWPDHGVPEYA--TSILQFHRRIKNEYK-------------PTKGPMLVHCSAGVGRTGT
                           . ... .|..|...|||||||..   .|.|.. ..|.. .|             . .||.|||||||||||||
vtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGt

FMAIDMGLQQAekEGGIDIISIINRMRQQRMK-MIQTADQYIFVNDAVLESVTC
. |... |..   |||.|. .... .|.||.  ..|. .||.|. ...|| . .
lvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 649-755 1.3e-35 117.8 In-house 138-245 (250) alignment 
Range on Protein: 649-755
Range on HMM: 138-245/250.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDA
.. |.||..||| ||||.||..|.. .... . .   ..|..|.|||||||.|.|.|||  |....||  .|.  .|...|..|...... .||.||  .
ivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyei

VLESVTCG
.|. ... 
ilkaldsv
subfamily_Ptp69D_pd Subfamily Ptp69D 649-768 3.7e-35 116.5 In-house 183-302 (307) alignment 
Range on Protein: 649-768
Range on HMM: 183-302/307.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAV
 ..|||.|.|.|  ||| |...|.. ..... ||  ..|..|||||||||.|.|.|.|. ||| ..|  .||. ..  .|.||  ..|  .||.|.  |.
kvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral

LESVTCGNTQVDSRNARIVF
|.  . |.|..| ..    .
ldyssygdtdedvddledai
subfamily_PTPRG_pd Subfamily PTPRG 649-765 1e-34 114.7 In-house 184-300 (563) alignment 
Range on Protein: 649-765
Range on HMM: 184-300/563.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAV
...|||.|.||||||||...  |.| .. .   | . ||..||||||||||||....|  |.| ..|  ...  .. ..| ||  ..|| .||||. ||.
lvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal

LESVTCGNTQVDSRNAR
|| .. ..|.. . . .
leaiasketellaeqve
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 650-759 1.5e-34 114.3 In-house 175-284 (315) alignment 
Range on Protein: 650-759
Range on HMM: 175-284/315.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVL
.||..|| |||.||.. ..|.|.. . .| . .. . ..|||||||||||| ...||  ..|....  .|.  ... .|..|....|| ..| |. ||||
vtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl

ESVTCGNTQV
| .   || .
edllwrntli
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 649-752 3.9e-34 113.1 In-house 171-276 (281) alignment 
Range on Protein: 649-752
Range on HMM: 171-276/281.0
MITQYHFTSWPDHGVPEYATSILQFHRRIK-NEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMIQTADQYIFVND
 ..| ..|.|||||||. .. .|.|.. ..  . | || |...|||||||||||..|.|  ....|.|   .|.  ... .|..|. |.||  || ||  
eveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvyk

AVLESV
|||. .
avldal
0051429 (Phosphotyrosine protein) phosphatases II 831-1042 6.2e-34 113.3 In-house 3-228 (272) alignment 
Range on Protein: 831-1042
Range on HMM: 3-228/272.0
HPDYINAVFINGYKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVMLCHENENDEEVCYQYWP-----------STQSALVIGEYNITLLNEDKSN
 ..|||| ...||     ..... .  |. .||..||..  . ....||.|..|.| . . |..|||           ..     .| . .||| |   .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

KYIERKFEVKNN-NTGAKQSVTQFQITNWDSTGEVKNPqtILLIIEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------V
 || |......  ..|.   |.... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESF
.....  | | ||.|||  ||.  ....|..|.|.
eeaveelraqrpgavqteeqylflyeallellrsl
0037934 (Phosphotyrosine protein) phosphatases II 641-750 1.6e-33 111.7 In-house 123-240 (243) alignment 
Range on Protein: 641-750
Range on HMM: 123-240/243.0
IV---VYQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--------YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAekegGIDIISIINRMRQ
..    .........||...|||||||.  ...|.|.. ...         . ...||.|||||||||||||. |... |..     |.|. ......|.
lenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllre

QRMK-MIQTADQYIFVNDAVLE
||.  ..|| .||.|. .|.||
qRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 648-759 1.7e-33 110.5 In-house 172-283 (515) alignment 
Range on Protein: 648-759
Range on HMM: 172-283/515.0
LMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDA
  .||.||| |||.|||. ..|.|.. . .| .    . |...|||||||||| ...||  . .|..   .|.  ... .||.|....|| .|| |. .|
rtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiyga

VLESVTCGNTQV
||| .   || .
vledllwrntli
subfamily_PTPN12_pd Subfamily PTPN12 649-753 6.9e-33 108.8 In-house 171-278 (290) alignment 
Range on Protein: 649-753
Range on HMM: 171-278/290.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGL---QQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVN
...|.|.|.|||||||. |.|.|.. . ...  .  . |..|||||||||||| .|||.     ..   .  .|. ... ..|.||  ..|| .|| .| 
kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvy

DAVLESVT
 ||.| |.
kavaelvq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 650-750 1.5e-32 107.7 In-house 138-238 (239) alignment 
Range on Protein: 650-750
Range on HMM: 138-238/239.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVL
. ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.|.  .||.  .. .|..| .|.||..||.|.  |||
vyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

E
|
e
0036282 (Phosphotyrosine protein) phosphatases II 833-1029 1.6e-32 108.0 In-house 3-160 (174) alignment 
Range on Protein: 833-1029
Range on HMM: 3-160/174.0
DYINAVFINGYKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPStqsalvigeynitllnedksnkyierkfevknNNTGA
||||| .....   . .|.   |.      ||.|. . ..|..|||..|.|.. . |..|||.                                . .  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lredl

KQSVTQFQITNWDSTGEVKNPQtILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTILQYQ
.... |.. ..|.  |.   .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||  ||.
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 768-1042 1.9e-32 107.1 In-house 14-286 (290) alignment 
Range on Protein: 768-1042
Range on HMM: 14-286/290.0
FNRMSKPDTKTGQTGYEEQFTVLQQVTQRPDEVTHNIASQNN--DKNRSTQFLPPNNHRVPLKNEHP-DYINAVFINGYKekKAFIIAESPMFNTARNFW
|....   .| .  ..  ..    .     . .  .|  .|    |||  .    .  || ||. .. ||. | ...| |    ||... .. .|. ..|
fekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiw

KMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQ-SALVIGEYNITLL-NEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGeVKNPQtiLLIIeE
.|. . .|.||||||   |.    | ||.| ..  .| .||. ..   ..|| .. | . . |.. ..| .  .  ..|  |     | . .  | ..  
rmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks.valst..lall.r

MYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLESF
. |. ||  .  .|||||  .||.  | |  ... .. ..|  .|. .. .. |  . .|||  .||  . .|.| .  .|
tlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 650-750 3.1e-32 106.7 In-house 139-239 (239) alignment 
Range on Protein: 650-750
Range on HMM: 139-239/239.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVL
. ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.|.  .||.  .. .|..| .|.||..||.|.  |||
vyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

E
|
e
subfamily_PTPN13_pd Subfamily PTPN13 650-752 4.1e-32 106.5 In-house 168-269 (273) alignment 
Range on Protein: 650-752
Range on HMM: 168-269/273.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVL
... .|..|||||||  |...||| .....  .  .||..||||||.||.||...||. |.  |..  .|.  |....|.||  ..|| ||||||  |.|
vahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail

ESV
| .
evl
0041856 (Phosphotyrosine protein) phosphatases II 808-1039 1.1e-31 105.3 In-house 1-171 (182) alignment 
Range on Protein: 808-1039
Range on HMM: 1-171/182.0
NNDKNRSTQFLPPNNHRvplkneHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenendeevCYQYWPstqsalvigeyni
| |||| . .||... |      ..||||| .. |.   . ||..  |. .|  .|..|. ....|.||.|.         ...|||             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

tllnedksnkyierkfevknnnTGAKQSVTQFQITNWDSTGEVKnPQTILLIIEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDV
                      .  .. ..|.. ..|.  |    ....| .|||...      .  ..||||  |||.....||   . .    | ...
......................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsl

FQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
....|  | ..||.|.|  ||.   ...| .|
eeavklvrsrRpgmvitpnqyfflqlallell
subfamily_PTPN6_pd Subfamily PTPN6 650-753 1.5e-31 104.6 In-house 188-298 (306) alignment 
Range on Protein: 650-753
Range on HMM: 188-298/306.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK----GPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---GIDIISIINRMRQQRMKMIQTADQYI
. ||||.||||||||.    .|.| . ...... ..    ||..||||||.||||||. ||. |.. ||.|    ||| .... .|.||  ..||..|| 
vfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqyk

FVNDAVLESVT
||  |. . . 
fvykaikkyie
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 649-760 4.1e-31 103.2 In-house 178-292 (297) alignment 
Range on Protein: 649-760
Range on HMM: 178-292/297.0
MITQYHFTSWPDHGVPE--YATSILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVN
.. ||.|..|||. |..   |.|.|..   ...... ..  |.||||.||||||| ...||  . .|..|  .||  .....||.|....|| .|| || 
vvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvy

DAVLESVTCGNTQVD
 |||| . . .|...
vavleallsedtriq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 650-787 7.6e-31 101.9 In-house 91-229 (440) alignment 
Range on Protein: 650-787
Range on HMM: 91-229/440.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAV
. |||. .|||.|||..|  .|.. . ... . |  .||.|||||||.||||  .|.|  |..|..   |||.|.|| ||..| .|.|| .|| ||..||
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

LESVTCGNTQVDSRNARIVFNRMSKPDTKTGQTGYEEQF
||.. ||.| .   .     ...  |. .| ..  ...|
legllcgdtliledditerveqiqwpnphtdksplqqef
subfamily_PTPN3_pd Subfamily PTPN3 649-750 1.1e-30 101.5 In-house 172-273 (280) alignment 
Range on Protein: 649-750
Range on HMM: 172-273/280.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAV
.|.|  ...|||||||. ....|.| .|...  . .. |..||||||.|||| ...... |.  |..  . .. |. .||.||. ..|||.|| || .|.
kilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai

LE
|.
lk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 650-757 1.2e-30 101.3 In-house 190-298 (301) alignment 
Range on Protein: 650-757
Range on HMM: 190-298/301.0
ITQYHFTSWPDHGV-PEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAV
..|.. |.||..|| .|..| .   .  |. . |. .||..||||..|.|.|.......|| |.  || .|.. .....|........| .||... |..
vlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi

LESVTCGNT
 . ... .|
dmylqlnst
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 647-750 1.8e-30 101.0 In-house 160-266 (274) alignment 
Range on Protein: 647-750
Range on HMM: 160-266/274.0
PLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE---YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIF
.  .. | .|.|||| .|. |...|.. . ....    .   .|..||||||.|||| |.||.....| ..|. .|...|.  .|..|  |.||..|| .
ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyel

VNDAVLE
.  |. .
ihralcl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 650-768 1.9e-30 100.7 In-house 176-295 (439) alignment 
Range on Protein: 650-768
Range on HMM: 176-295/439.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAV
. |.|...|||. ||  |. .|.| | |.  . |   ||..|||||||||||| .|.|. |.|   |  .||  |.. .|.|| .|.|.  ||.|. .||
vlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav

LESVTCGNTQVDSRNARIVF
|| .  |.. |   . .  |
ledivyGdiavtidefkkef
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 807-1036 2.1e-30 100.7 In-house 2-236 (237) alignment 
Range on Protein: 807-1036
Range on HMM: 2-236/237.0
QNNDKNRSTQFLPPNNHRVPLKNE--HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSALVIG
.|. |||  .    .  || ||      ||||| ...|.    | .| |. |. ..  .||.|. . . . ||||    |..|. |..|||||.     |
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

EYNITLLNEDKSNKYIERKFEVKNNNTGA-KQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 . ..|  ...   |  | . . .. |    . . |.|.| |   |  ..  ..| .  ..    ..    .  ..|||  |||...|    . . ..| 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

EGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVL
. |.|... ..|   ..|  .||  ||  ..| .|
kkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0036282 (Phosphotyrosine protein) phosphatases II 621-746 3.1e-30 100.5 In-house 38-164 (174) alignment 
Range on Protein: 621-746
Range on HMM: 38-164/174.0
EHIVTVGLSPSNK--LLNRFANIVVYQPPLMITQYHFTSWPDHGVPEYATsILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEkEGG
...|..  .  ..  .  .. .   . .  .. ||... |||||||. .. .|.| ..... ..   .||.|||||||||||||..|... |.. . |. 
ttvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.esl

IDIISIINRMRQQRMKMIQTADQYIFVND
.|..... ..|.||..|.|| .||.|. .
vdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 650-768 3.1e-30 100.6 In-house 187-307 (319) alignment 
Range on Protein: 650-768
Range on HMM: 187-307/319.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDA
|||.||  |||.|||.|.. .... ....     .  . ...|||||||||||.....|. |.. ..|  .|.  ... .|||| ...|   || |.  |
itqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa

VLESVTCGNTQVDSRNARIVF
.||    |...|   .    .
lleehlfghsdvampdfpayl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 797-1038 4.3e-30 99.4 In-house 36-235 (392) alignment 
Range on Protein: 797-1038
Range on HMM: 36-235/392.0
PDEVTHniASQNNDKNRSTQFLPPNNHRVPL----KNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDeevcyqy
|. |..     |  |||  . || .. || |       . ||.|| .|.... .||.| ...|   .  .||.|. . |||.|.|. . .| |       
pqtvaq..keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......

wpstqsalvigeynitllnedksnkyierkfevknnNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMyrtQRKRGNTS--IVVHCSDTVGRSAMFC
                                    .   ...|.||..|.|   .  |   ..| .|.|.   . . |. .  ...|||  |||...  
....................................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvi

AAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAY
.  . . ..|.  ..|||...   | ..|  |||  ||  ..  ||  
sidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 649-771 7.8e-30 99.3 In-house 150-274 (284) alignment 
Range on Protein: 649-771
Range on HMM: 150-274/284.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVND
 |.|.||  |||.|||.|.. .... ....     .  . ...|||||||||||.....|. |.. ..|  .|.  ... .|||| ...|   || |.  
kirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

AVLESVTCGNTQVDSRNARIVFNRM
|.||    |...|   .    ....
alleehlfghsdvalpdfpayleel
0051429 (Phosphotyrosine protein) phosphatases II 640-751 9.6e-30 99.5 In-house 112-224 (272) alignment 
Range on Protein: 640-751
Range on HMM: 112-224/272.0
NIVVYQPPLMITQYHFTSWPDHGVPEYAtsILQFHRRIKNeykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID--------IISIINRMRQQR
... .. .......|.|.|||||||. |  .|.. . . .     .||.|||||||..||||. |... |.. ..|  .|        .  .....|.||
lllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqr

MKMIQTADQYIFVNDAVLES
....|| .||.|. .|.|| 
pgavqteeqylflyeallel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 649-767 1.4e-29 98.3 In-house 179-303 (325) alignment 
Range on Protein: 649-767
Range on HMM: 179-303/325.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEY---KP---TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYI
 . |... ||.| ||... .... . . .|.     .    . .|.||||||||||||.|...   |..  .|  .||   ....|..| .|..|.||||
svkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyi

FVNDAVLESVTCGNTQVDSRNARIV
.. .|. | . .|||.|   .    
liyealveaymsgntdvpvssfeak
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 649-750 1.9e-29 97.6 In-house 134-237 (237) alignment 
Range on Protein: 649-750
Range on HMM: 134-237/237.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVND
.| ||.||||||.|||......|.| ..| |. .  .  || ..|||||||||| |. ||  |.||...  .||   .  . ..|  .||| |||.|...
lihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihq

AVLE
..||
tile
0041856 (Phosphotyrosine protein) phosphatases II 612-758 2.1e-29 97.8 In-house 51-177 (182) alignment 
Range on Protein: 612-758
Range on HMM: 51-177/182.0
FMMLDRGESEHIVTVGlspsnkllnrfanIVVY---QPPLMITQYHFTSWPDHGVPEyATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMG
. || .    .||..               . |     . ...||....|||||||.   ..|.| .....     .|| |||||||||||||. |... 
lrmlkelgittivnlt.............eelywpellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylm

LQQaekegGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLESVTCGNTQ
...     |... .... .|..|..|..| .||.|. .|.|| . ...|.
kkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_PTPN9_pd Subfamily PTPN9 650-751 4.4e-29 96.4 In-house 175-289 (297) alignment 
Range on Protein: 650-751
Range on HMM: 175-289/297.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-------------EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQ
.| . |.||||.|||. |.|.|.. . ...             ...|.. |..||||||.||||||...|. |.. |..| .|..  ....|.||  .||
vthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiq

TADQYIFVNDAVLES
| .|| |   |||| 
tpeqyefcylavley
0043147 (Phosphotyrosine protein) phosphatases II 609-744 9e-29 95.8 In-house 34-153 (172) alignment 
Range on Protein: 609-744
Range on HMM: 34-153/172.0
RNQFMMLDRGESEHIVTVGlSPsnkllnrfaNIVVYQPPLMITQYHFTSWPDHGVPeYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDM
   . || .    |||..  .              ..   .. ||....|||||||  .  .|.| . |..   .  .||.|||||||||||||. |...
adfwrmlkelgithivnlt.el.........lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaayl

GLqqaekeGGIDIISIINRMRQQRMKMIQTADQYIFV
 |       |...  ... .|..|....|. .||.|.
ml......lglsleeavalvrekRpgavqnpsqyrfl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 645-760 1.3e-28 94.7 In-house 159-274 (283) alignment 
Range on Protein: 645-760
Range on HMM: 159-274/283.0
QPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFV
.  |... | .  | . |      |...| . | .  .  |||..||||.|.|||..|.|.   ...|  |  .|. .... ||.||| ..|| ||| .|
kstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklv

NDAVLESVTCGNTQVD
 ..|||   ||.||. 
helvleqalcgdtqia
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 650-751 1.5e-28 94.5 In-house 154-263 (270) alignment 
Range on Protein: 650-751
Range on HMM: 154-263/270.0
ITQYHFTSWPDHGVPEYAT------SILQFHRRIKNEYKPT-KG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQY
.. .....|||||||. .       ..|.  | ...  | . |. |.|||||||||||||..|.|....  |... .|...||...|..||...|. .||
lvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqy

IFVNDAVLES
 |.  ||.| 
eflykavvey
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 783-1047 1.6e-28 94.6 In-house 18-287 (307) alignment 
Range on Protein: 783-1047
Range on HMM: 18-287/307.0
YEEQFTVLQQvtQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNE--HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
  ..|.|| .  . |. || .  | |.|||| ..    .. |. .| .    ||| | ..    . | || |. |. ||  .|| |. . .| ...|||.
lvdefrvlak..ktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

ENENDEEVCYQYWPSTQS-ALVIGEYNITLLNEDKSNKYIE---RKF---EVKNNNTGAKQSVTQFQITNWDSTGevkNPQTILLIIEEMYRTQRKrgNT
  |  .  | ||||  .   || || . |.  ..   | .          ..| . ..  ......| .||   |    ||. |  |. .  .. .  . 
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrg...vpqinltainlleavryd..tn

SIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAY-LESF-ETYSN
 .|||||  ||||    | .   .|  . .   |. ....  | |.. ..|| .||  . ...| | || . ||| .
pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyee
subfamily_PTPN1_pd Subfamily PTPN1 649-761 6.8e-28 92.2 In-house 163-282 (290) alignment 
Range on Protein: 649-761
Range on HMM: 163-282/290.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQRMKMIQTADQYIF
 |...|.|.||| ||||  .. |.|  ....    .. .|| ..|||||.||.|||. .|  | . ||..    .||   .  .|..|. .||||||  |
eilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrf

VNDAVLESVT--CGNTQVDS
   |.|| .    |.. |..
sylaileGakvikgdssvqk
subfamily_PTPRN_pd Subfamily PTPRN 649-752 8.3e-28 91.9 In-house 188-292 (297) alignment 
Range on Protein: 649-752
Range on HMM: 188-292/297.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMIQTADQYIFVNDA
 .||.|| |||..|||  | |.|.| |..   |.    |..||||.|.||||....||. |..  |    |||.. .. .|.|| ....| ||. |.  |
tvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta

VLESV
| | |
vaeev
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 650-759 9.9e-28 91.6 In-house 134-243 (392) alignment 
Range on Protein: 650-759
Range on HMM: 134-243/392.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVL
..|.||| |||..||....|.|.| . .| ..     |...||||||||||  ..||  . .|.|   .|.. ..  .|..|  |.|| .|| |.  |||
vaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl

ESVTCGNTQV
| .   || .
edllwrntli
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 791-1028 1.1e-27 91.6 In-house 33-270 (301) alignment 
Range on Protein: 791-1028
Range on HMM: 33-270/301.0
QQVTQRPDEVTHNIASQNNDKNRSTQFlPP--NNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEV
.  |   |..|.  |  ..||.|  .  |   .     ... .   | | .|.   . . ||.. .|. ||. .|| |.   .|  ||||... |. ||.
nvttidkdhitesyaylpkdkhryptv.PckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleek

CYQYWPST-QSALVIGEYNITLLNEDK--SNKYIERKFEVKNNNT-GAKQSVTQFQITNWDSTGEvknPQTILLIIEEMYRTqrKRGNTSIVVHCSDTVG
| .| |.. .. | || ..|.. |...  ..| ..|..||..     | ..|| .| ..|   |    |..   . . |     |. .  ||||||. .|
ceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgv...Pkshaelfdlmelv..kksekPivvhcsaGiG

RSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQY
||  | ..    .. ...  |.. . ||  | ..  .|||  | 
rsvafigteylareveadptieltealkhlrehrwngvqtnsql
0046846 (Phosphotyrosine protein) phosphatases II 824-1040 2.9e-27 90.9 In-house 4-174 (176) alignment 
Range on Protein: 824-1040
Range on HMM: 4-174/176.0
RVPLKNEHPDYINAVFINGYKekkaFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSALVigeynitllnedksnkyierkf
|..  ....||||| .| |..    .|.   |. .|  .|..|. . ..||.|.|. | | .   |..|||  ... .                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

evknnntgakqsvtQFQITNWDSTGEVKNpQTILLIIEEMYRTQRKRgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSV
              |.. ..|.  |     . .| ..|.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.|
..............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTILQYQGMFQIVLAYLE
||  ||.   . .| .|.
qtpeQyrflyefellllk
0048076 (Phosphotyrosine protein) phosphatases II 643-748 3.5e-27 90.2 In-house 40-139 (145) alignment 
Range on Protein: 643-748
Range on HMM: 40-139/145.0
VYQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDMGLQqaekeGGIDIISIINRMRQQRMKMIQTADQYI
 . .  ...||....|||||||. .  .|.| . |.. .|   ||.|||||||||||||..|... |.      |... ......|.||...... .|..
lellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlr

FVNDAV
|. ...
flyefe
0049260 (Phosphotyrosine protein) phosphatases II 612-745 3.7e-27 90.3 In-house 26-143 (152) alignment 
Range on Protein: 612-745
Range on HMM: 26-143/152.0
FMMLDRGESEHIVTVGLSPSNKLLNRFANIvvyqpplmitQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqq
. || .    .||..     .. |     |          ||... |||||||. .  .|.... |.  ..  .|| |||||||||||||..|... |  
wrmlkelgittivmltellelgklkceqyi..........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..

aekeGGIDIISIINRMRQQRMKMIQTADQYIFVN
     |...  .....|..|...... .|..|. 
....lgvsleeavalvrekRpgavpnpgqlrfly
0043147 (Phosphotyrosine protein) phosphatases II 830-1030 4.1e-27 90.4 In-house 3-152 (172) alignment 
Range on Protein: 830-1030
Range on HMM: 3-152/172.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEnendeevcyqywpstqsalvigeynitllnedksnkyierkfevKNNN
|. ||||| ....|   . ||.   |. ||   ||.|. ....|.||.|. .                                             .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

TGAKQSVTQFQITNWDSTGEVkNPQTILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTILQY
.. .... |.. ..|.  |   ... .| ..| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||.  ||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqy

QG
. 
rf
0048179 (Phosphotyrosine protein) phosphatases II 634-745 4.3e-27 90.0 In-house 44-138 (144) alignment 
Range on Protein: 634-745
Range on HMM: 44-138/144.0
LLNRFanivvyqpplmITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekEGGIDIISIINRMRQQRMK
 | |.           ..||....|||||||.... .|.| . |.. ..  .||.|||||||||||||..|... .     . |... ......|..|. 
flere...........giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpg

MIQTADQYIFVN
.... .|..|. 
avpnpgqlrfLl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 777-1037 8.8e-27 88.6 In-house 16-277 (439) alignment 
Range on Protein: 777-1037
Range on HMM: 16-277/439.0
KTGQTGYEEQFTVLQQVtqRPD-EVTHNIASQ--NNDKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDD
|  |  ..| |  .. .  .|| ..  ..|.|  .. |||  .  . .  || |.      |  |||| .|.|| ..| .| .. |  .|. .||... .
knkqeifkeifekinst..spdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie

RNVTAIVMLCHENEndeevCYQYWPSTQSAlVIGEYNITLLNEDKSNKYIERKFEVKNNNTG--AKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQ
.... ||||.   |      |.|||| . . . |.  .    . .  .|. | | | |.      ...| ||. . |       .   .|  .  .  ..
kktvtivmltnlve.....sykywpsdaev.cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan

RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLA
 |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||.. ||  ... || 
dkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 809-1035 1.2e-26 88.3 In-house 8-236 (239) alignment 
Range on Protein: 809-1035
Range on HMM: 8-236/239.0
NDKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSALVig
. ||| .. .  .  || |.    . | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| . |  .  
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc..

EYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNpQTILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG
.  .|| . .    || | | . .     .. | |...| |   |  .   | .| .      .   |    |.|||  |||.  |    . . ..| . 
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

VIDVFQVLKSQRIQKPGSVQTILQYQGMFQIV
 .|.|. .|. | ..|  |||  ||  ..  |
tvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 808-1035 1.6e-26 88.0 In-house 8-237 (239) alignment 
Range on Protein: 808-1035
Range on HMM: 8-237/239.0
NNDKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSALVi
|. ||| .. .  .  || |.    . | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| . |  . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc.

gEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNpQTILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE
 .  .|| . .    || | | . .     .. | |...| |   |  .   | .| .      .   |    |.|||  |||.  |    . . ..| .
.nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIV
  .|.|. .|. | ..|  |||  ||  ..  |
ktvdifnyvkairedrphmvqtseqyvfihlav
0049772 (Phosphotyrosine protein) phosphatases II 807-1045 3.3e-26 88.2 In-house 45-286 (314) alignment 
Range on Protein: 807-1045
Range on HMM: 45-286/314.0
QNNDKNRSTQFLPPNnHRVPLKN---EHPDYINAVFINGYkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVM--------------
 | ||||....|| . .|| |..   .  ||||| ...|.   ..||... |. .|  .|          |.|.  .|.||  |||              
lnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCHENENDeevcyQ-YWPSTQSALVigeynitllnedksnkyierkfEVKNNNTGAKQSVTQFQITNWDStGEVKNPQTILLIIEEMYRTqrk
       |.   .|        ......  |                       |. ...   .. . ..  ....  |..  .. .. ..| . .    
aAlgKtpllildgng.....neptaadlellk......................eelydpelferlgikylripvpD.gsaplledfdeflefieea...

RGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTILQYQGMFQIVLAYLESFETY
. .. ..|||.. .||.. |..||  . ..   || .. ..|.  | . |     |.... .||. .....| ||. ....
dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
0046846 (Phosphotyrosine protein) phosphatases II 641-749 3.4e-26 87.5 In-house 77-170 (176) alignment 
Range on Protein: 641-749
Range on HMM: 77-170/176.0
IvvyqpplmitQYHFTSWPDHGVPEYaTSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDmglqQAEKEGGIDIISIINRMRQQRM-KMIQTAD
|          ||... |||||||.. . .|.. . |.. .|   || |||||||.|||||. |..      |.| |...  .. ..|.||. ...|| .
i..........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYIFVNDAVL
|| |. ...|
Qyrflyefel
0049260 (Phosphotyrosine protein) phosphatases II 839-1029 6.1e-26 86.3 In-house 1-140 (152) alignment 
Range on Protein: 839-1029
Range on HMM: 1-140/152.0
FINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWpstqsalvigeynitllnedksnkyierkfevknnntgakqsvtQ
||.||. ...||... |. ||. .||.|. . ..|.||||. . |.... |.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

FQITNWDSTGEVKNPQTILLIIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTILQYQ
.. ..|.  |  ...| .| ... . .  ... .  ..||||  |||.....||   .        ........  | ..||.|..  |..
ylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlr
subfamily_CG7180_pd Subfamily CG7180 649-757 1.2e-24 81.4 In-house 181-295 (296) alignment 
Range on Protein: 649-757
Range on HMM: 181-295/296.0
MITQYHFTSWPD-HGVPEYATSILQFHRRIKN-----EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYI
.......| |.  . ||  ....... ||..      . .|..||..|..| |..|.| ..|||. |...|||. .|.   . ..|..| ..... ..| 
ivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYk

FVNDAVLESVTCGNT
.. | .|| | |. .
yiYdvlleavlcnkd
subfamily_PTPN23_pd Subfamily PTPN23 648-753 2.4e-24 80.6 In-house 171-281 (288) alignment 
Range on Protein: 648-753
Range on HMM: 171-281/288.0
LMITQYHFTSWPDHGVPEYATSILQFHRRIKNE----YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINRMRQQRMKMIQTADQYI
 ...  ..||||..|||.   ..|||   ...      ...| |..|||||||||||.|  .   ... ||. |. ||| ...|.|.||  |.|. .|. 
ksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk

FVNDAVLESVT
|. .|||| . 
fsyeavleaar
0044763 (Phosphotyrosine protein) phosphatases II 614-746 3.6e-24 80.8 In-house 43-165 (178) alignment 
Range on Protein: 614-746
Range on HMM: 43-165/178.0
MLDRGESEHIVTVGlspsNKLLNRFANIVVYQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQae
.| .    |||..     . | . | .   | |  .  ||... .||||||.    .|.|.. |.. ... .|| ||||||||||.||..|... ...  
llkelgithivnlt....eelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl..

kegGIDIISIINRMRQQRMkMIQTADQYIFVND
   |... ..|...|..|. .... .|. .. .
...glsleeaielvrerRp.ivpnpgqlrqLye
0051082 (Phosphotyrosine protein) phosphatases II 648-748 4.6e-24 80.1 In-house 58-149 (151) alignment 
Range on Protein: 648-748
Range on HMM: 58-149/151.0
LMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekeggIDIISIINRMRQQRMKMIQTADQYIFVNDA
. ........|||.|.|..  ..|.|.. . .   . .||.|||||||.|||||..|... |..      ... .... .|..|. ..|. .|..|.  |
ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa

V
.
l
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 807-1040 3.8e-23 76.9 In-house 42-272 (288) alignment 
Range on Protein: 807-1040
Range on HMM: 42-272/288.0
QNNDKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSAL-VIGEY
.|  ..| ..    .  || |...   ||.|  .   | |. .| |..|.  |  ..|||. . .|  |||||.  |   |   .|.|| .     || .
anptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

-NITLLNEDKSNKYIERKFeVKNNNTGAKQS-VTQFQITNWDSTGEVKNPQTILLIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG
 ...  . .  .| ..    ......| ..  | .  . .||  |  .| .. | ..| .     |  .  ||||.|  |||.. .      ..  . . 
ctvvkkkradidklvkvsl.lriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrldd

VIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLE
 . . ..|.. | ..  ..||  ||  ....|| .| 
flgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 805-1038 4.4e-23 76.3 In-house 34-268 (281) alignment 
Range on Protein: 805-1038
Range on HMM: 34-268/281.0
ASQNNDKNRSTQFLPPNNHRVPLKN-----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQS-
   || ||| ..    .  || ||      .  ||| | .|     |. .|... |  .|  .||.|| . | |||||||.  | . | | .|.|     
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

ALVIGEYNITLlnED-KSNKYIErKFEVKNNNTGAKQSVTQFQITNWDSTgEVKNPQTILLIIeemYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTIN
.| . .. ..   ||   || .     ..    |  . .|..   .|    .| .   ..| |    |  | |  |  |.|||  ||||  . |   ...
clqfdklsvsy..edstvnkslv.ttrlnlsyegetrlithwlwkewpdw.qvpessevmlki...lrkirar.stppvihcsagvgrsgtlmaveialq

KCKTEG-VIDVFQVLKSQRIQ-KPGSVQTILQYQGMFQIVLAY
  ..   . |. |..   |.  .  ||||. ||  .....| .
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_PTPN14_pd Subfamily PTPN14 652-752 4.8e-23 76.6 In-house 187-296 (300) alignment 
Range on Protein: 652-752
Range on HMM: 187-296/300.0
QYHFTSWPDHGVPEYATSILQFHRRIK------NEY---KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYI
   .| ||||||||  .. |.. ....      |.    | .| |.||||||||||||  .  |. ..  |..  ||| ....|.|.||| ..||  || 
hlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYk

FVNDAVLESV
|| .......
fvYkvlikyl
0049772 (Phosphotyrosine protein) phosphatases II 648-753 1.1e-22 76.6 In-house 178-281 (314) alignment 
Range on Protein: 648-753
Range on HMM: 178-281/314.0
LMITQYHFTSWPDHGVPeYATSILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAekegGIDIISIINRMRQQRM-----KMIQTADQYI
 .. .|. . .||...|     ...| . |..   ...|| ||||.||.||||||..... . .     |...  .....|..|.      .|.. .||.
rlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqye

FVNDAVLESVT
|. .|.|| . 
filealleylk
subfamily_ptpA1_pd Subfamily ptpA1 785-998 1.1e-22 75.3 In-house 25-255 (418) alignment 
Range on Protein: 785-998
Range on HMM: 25-255/418.0
EQFTVLQQVtQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKN----EHPDYINAVFINGYKEkKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
|.| .|..    | | .     .|  ||| |. || |  || ||.    |  ||||| .|.|    | || .. |. ||  .||.|. .  .  |||| .
eefrllees.vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsr

ENENDEEVCYQYWPST----------QSALVIGEYNITLLN--EDKSNKYIERKfeVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQR
|.||    | .|||            .   |.| |.. |..  .|   . | |.  ..    |  . .||.|   |         | .  ..  .   | 
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrn..irltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

-----KRGNTSIVVHCSDTVGRSAMFCAAATTINK
        |  |.||||  |||.  ||.|   ..|
qiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 587-644 1.9e-22 74.5 In-house 1-58 (290) alignment 
Range on Protein: 587-644
Range on HMM: 1-58/290.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDRGESEHIVTVGLSPSNKLLNRFANIVVY
||||..||||||||||||||||||||.||| ||||| |||||..||||||||||||||
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvy
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 797-1039 7.5e-22 72.6 In-house 24-270 (285) alignment 
Range on Protein: 797-1039
Range on HMM: 24-270/285.0
PDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEHPDYINAVFIN-GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPS
| ..|.     | | || ..    .. || |||   ||| | ..    |.. ..| .. |. .|  .||.|| . ... ..|||   |   | |  |.| 
ppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

TQSALV-IGEYNITLLN--EDKSNKYIERKFEVKNNNTGAKQS--VTQFQITNWDSTGevkNPQTILLIIeEMYRTQRK--RGNTSIVVHCSDTVGRSAM
    .| .|.|.||| .  |.     |   . | | .  . .   . . |.  |        |.    .| |.|.  .|    .. |.||||  |||.| 
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdql...apedarpmi.elykwvkkvnpkekpicvhcsagvgrtat

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
|     .  .   .  |.......  |  .  .||. .|.  .. ... |.
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_egg_pd Subfamily egg 782-1039 8.2e-22 72.2 In-house 15-270 (307) alignment 
Range on Protein: 782-1039
Range on HMM: 15-270/307.0
GYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVM
..| .. ||......   .|. ... | .| || .    .  || |. ..     |.| |  ..|      ||.|..|. ||  .||.|.   .|  |||
elerrlevleesvde.islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

LCHENENdeEVCYQYWPSTQS-ALVI--GEYNITLLNEDKSNKYIERKFEVKNNNTGA-KQSVTQFQiTNWDSTGEVKNPQTILliieemyRTQRKRgNT
|    |.  | |  ||| ..| .||.  | ..|. |. |.    . |  ..|   .   .. .  .|  ... ...|  |  .|       |  |.   .
ltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysplrvl.......rklrnl.sk

SIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTILQYQGMFQIVLAYL
 .||.. . | ..| . |. ... .    | |  . ||..    | ... ||...|.|  ....|| ..
pvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 650-750 1.9e-21 71.1 In-house 188-285 (305) alignment 
Range on Protein: 650-750
Range on HMM: 188-285/305.0
ITQYHFTSWPDHGVPEYATSILQFHRriknEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID-IISIINRMRQQRMKMIQTADQYIFVNDAV
.|.||.  ||| |||   ..||..      . .|.|||. ||||||.||||. . ..  |.|      |.    |....|.|| . ||| .||.|| . .
vthyhwidwpdrgvpaadlailelle....karpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi

LE
|.
ln
0051082 (Phosphotyrosine protein) phosphatases II 831-1031 1.9e-21 71.7 In-house 2-145 (151) alignment 
Range on Protein: 831-1031
Range on HMM: 2-145/151.0
HPDYINAVFINGYkekkaFIIAESPmfntARNFWKMIDDRNVTAIVMLCHENENDeeVCYQYWPSTQsalvigeynitllnedksnkyierkfevknnnt
..||||. .. |.     ...   |       |.... . ....||.|. | |..   |..|.|...                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

gakQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTILQYQG
     |....|..|. .|   .....| ..|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||.  |.. 
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

M
 
q
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 806-1039 3.6e-21 70.1 In-house 53-289 (305) alignment 
Range on Protein: 806-1039
Range on HMM: 53-289/305.0
SQNNDKNRSTQFLPPNNHRVPLKNEHP-DYINAVFING-YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSALVIG
  .  ||| ..    ..  | |..  | ||| | ..      .| || |. |. .|  .|| |. ...|  |||||.  |     | |||| .|   .  
diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

EYNITLLNEdKSNKYIERKFEVKNN------NTGAKQSVTQFQITNWDSTGEvknPQTILLIIEeMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTIN
   | . |    .| .||  |..        . . | || ..| |.|   |    |   |  .| .  . |   .  ||||||  .||.    |    ..
ksgivvenv.sgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv...ppckltsle.llsair.gskvpivvhcsagigrtgtivaieyile

KCKTE-GVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
|   .  .  . ...|. | |.  |.|. .||  . ...| |.
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 587-645 4.4e-21 70.1 In-house 1-60 (287) alignment 
Range on Protein: 587-645
Range on HMM: 1-60/287.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDR-GESEHIVTVGLSPSNKLLNRFANIVVYQ
|||||.||||||.|||||||||.|||..|.. ...|. ||......|| .||...|.|..
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpd
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 782-1040 6e-21 69.5 In-house 23-288 (305) alignment 
Range on Protein: 782-1040
Range on HMM: 23-288/305.0
GYEEQFTVLQQVTQRpDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEHP-DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
|  ..|. .... .  . .     .|...|||  .    .| || |..  | .|| | ..    . | || ...|. .|  .|| |  . .| || ||| 
glraefvamkrfndf.ekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcn

ENENDEEVCYQYWPSTQSA-LVIGE--YNITLLNEDKSNKYIERK--FEV------KNNNTGAKQSVTQFQITNWDSTGevkNPQTILLIIEEMYRTQRK
  |   . |..|..| .   | . |    |..  |  ..  ....   .|       .   . .. ||..   .|   |    | . | |.| . ...  
llekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg...vpaadlailellekarps

RGntSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYLE
.|   ||||||  .||.         ...  .  .|.   ..|.  | |.  |.||  ||  . |..| |..
kg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
PTPc_DSPc_SM00012 936-1035 8.1e-21 69.6 In-house 2-103 (105) alignment 
Range on Protein: 936-1035
Range on HMM: 2-103/105.0
VTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTILQYQGMFQ
|.....|.|  .|  .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.|||  ||. . .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IV
..
al
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 646-754 1.3e-20 68.6 In-house 169-273 (288) alignment 
Range on Protein: 646-754
Range on HMM: 169-273/288.0
PPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVN
 . .. . |.  |.|.||||   | |..  ..|.  |    |..||.|||||||||.. | . |...  .  . | |.....|..|.| |||  ||..| 
ekvivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvh

DAVLESVTC
  ||| .  
rcvleelll
0044763 (Phosphotyrosine protein) phosphatases II 827-1033 1.4e-20 69.1 In-house 13-165 (178) alignment 
Range on Protein: 827-1033
Range on HMM: 13-165/178.0
LKNEHPDYINAVFINGYkekkaFIIAESPMfntaRNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSalvigeynitllnedksnkyierkfevk
   |  |||||..| ..     ....  |.     ...... . ..|.||.|..| |.  . |..|||.  .                            
eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag............................

nnntgakqsvTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTIL
           |.. ....  |.   .. .| ..| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..  
..........iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpg

QYQGMFQ
|.. . .
qlrqLye
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 650-744 4.2e-20 66.4 In-house 190-280 (302) alignment 
Range on Protein: 650-744
Range on HMM: 190-280/302.0
ITQYHFTSWPDHGVPEYATSILQFHRRIkNEYKptkGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFV
.   .|..||||| |. | . |.  .   . ||     .|||||||||||||..||  |.|   |.   |..||.  .|| |   .|...| |..
vdilafsawpdhGapkeaytaldilkfc.esyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 777-1038 5.5e-20 66.1 In-house 23-289 (310) alignment 
Range on Protein: 777-1038
Range on HMM: 23-289/310.0
KTGQTGYEEQFTVLQqvTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLK---NEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
| |  |   |.  |.  ...   .|..   ..  ||| .. .  .. || ||     . ||| | ...    ...|| .. |.  |  .||.|| .    
klgieglvkqyrkld..akqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqerae

AIVMLCHENENDEEVCYQYWPSTQSALVIGEYNITLLNEDKSNKYIER---KF---EVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQ
.|..||.  |.    |  ||||   .   |   .| |.|   .  |      |   .|  ..  |.    . .. .|    .   |.     . .   .|
silllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaq

RKRGNtsIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAY
 . |    |||||  ..|  . .|   .|.| .    .|. .|    . ..   .|| |||  . .. ...
vrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 650-750 1.1e-19 65.2 In-house 185-281 (290) alignment 
Range on Protein: 650-750
Range on HMM: 185-281/290.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVL
.  ..  ||||. |.  . ..|.  | ...    . ||. ||||||.||||||.||..|||   .   .|.. ..  .|. |.. .|   ||. . ...|
lkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveill

E
.
d
subfamily_CG42327_pd Subfamily CG42327 785-963 3.2e-19 63.8 In-house 9-190 (319) alignment 
Range on Protein: 785-963
Range on HMM: 9-190/319.0
EQFTVLQQVTQRPDevthNIASQNNDKNRSTQFLPPNNHRVPLK----NEHPDYINAVFINGYKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIVMLC
|.|  | |.  | |    ..    .||.|  . .|  . || |.    ...  |..| .. ||.. .. .| |. .. ... .||... ...   || |.
eefrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

HENENDEEVCYQYWPSTQS---ALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQItNWDSTGEVKNPQTILLIIEEM
   |.  .|| .|.|. ..     . |.. .|| . .  ..|.   . .|. .    . .| .   .|  ..   ...... .. |.
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 788-956 3.3e-19 63.5 In-house 74-242 (244) alignment 
Range on Protein: 788-956
Range on HMM: 74-242/244.0
TVLQQVTQRPDEV--THNIASQNNDKNRSTQFLPPNNHRVPLKNEH--PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENE
    |   |||       .  .|. |||    || .  |||| .      |||| |.        .|... |. .|. .||||. .| |  .|.|   .|
iqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee

NDEevcyqYWPSTQSaLVIGEYNI--TLLNEDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTI
.||     ||| ..  |   | .|  || . |.  .    ..|.. .   ..|..| |||.|| | |   |   |
ede.....ywpdsep.lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpndhfi
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 675-750 1.5e-18 61.7 In-house 182-257 (267) alignment 
Range on Protein: 675-750
Range on HMM: 182-257/267.0
RRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLE
   ||. .    |..|.||.||||.|||. ||  |..| .||  ||   . ..|.||. ...| ..||.. . . |
ilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 804-1039 1.7e-18 61.1 In-house 47-285 (302) alignment 
Range on Protein: 804-1039
Range on HMM: 47-285/302.0
IASQNNDKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTA---RNFWKMIDDRNVTAIVMLCHENENDEeVCYQYWPSTQSAL
.  .| .||.|...  .....| |..|  .|.||  ..  . ..  |.|  |  ...    .||.|. ..... .|.|  |.| ..    ...| .. . 
afkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

VigEYNITLLNEDKSNKYIERK----FEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTI
.  ||.   .|  | .|  | |     ||  ..      ..   .||| ..   ..  ..   .....  .   .. ..|.     .|| ..| ..|...
k..eygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfa.kkikadentvivSknGaGRagafltlavav

NKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
.| ...    . ...|| | |.| .|... ||  .. ..| |.
eklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 624-749 4e-18 60.3 In-house 205-341 (350) alignment 
Range on Protein: 624-749
Range on HMM: 205-341/350.0
VTVGLSPSNkllnrfanivvyqpPLMITQYHFTSWPDHGVPEYATSILQFHR--------RI-KNEYKPT-KGPMLVHCSAGVGRTGTFMAIDMGLQQ--
. . |..|.              |... | ..  |.| ..     ||||            . .. ..     |.|||||||||||||....|. |..  
taitlaasd..............PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfe

----A-EK-------EGGIDII-SIINRMRQQRMKMIQTADQYIFVNDAVL
      ..           |.|  |.|..|.||..|.|. ||.||. .|.|
ilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 832-1031 5.2e-18 60.2 In-house 46-251 (290) alignment 
Range on Protein: 832-1031
Range on HMM: 46-251/290.0
PDYINAVFINgYKEKKAFIIAESPMFNT-------ARNFWKMIDDRNVTAIVMLCHENENDEE----VCYQYWPSTQS-ALVIGEYNITLLNEDKSNKYI
 ||| | ..  . .  ..|. .||  ..         .|| |. . .|. .||||  .|....     | .| | .    | ..  ..   .  | .  .
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

ERKFEVKNNNtGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQK
.|. .|| .. . .  ||  .. .|...   ....|.| .|. .     |  .| ..||| | . |||.. |      |   |.| . . .|||. | |.
tRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

PGSVQTILQYQGM
   ... |..  .
alaitsalelafv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 649-749 9.9e-18 58.9 In-house 169-274 (287) alignment 
Range on Protein: 649-749
Range on HMM: 169-274/287.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-----KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIF
.. |... ||||....  | ....|   .|.           ||..||...|.||.|...|. . ... |. | .|.  .. |.|..|  ..|.. |. .
vvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrl

VNDAVL
. .|. 
lyealv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 628-750 2.3e-17 58.0 In-house 155-275 (307) alignment 
Range on Protein: 628-750
Range on HMM: 155-275/307.0
LSPSNKLLNRFAN-IVVYQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQ-AEKEGGIDIISIIN
|.| ..|.|  .  ..  |    |... .. |||.|||.   . . .   .. .    . |..|||||||||.|| .|| .  ..  . .   |.  ...
lapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklve

RMRQQRMKMIQTADQYIFVNDAVLE
 .|.||   |||  ||...   .||
elrsqrhyaiqteaqylylhrvlle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 647-752 1.1e-16 55.7 In-house 166-270 (285) alignment 
Range on Protein: 647-752
Range on HMM: 166-270/285.0
PLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVND
|| . . .   |||.  || |  ...... .|.  .| . |. |||||||||| ||. ||    .  ..  |... |.  ||  |.. .|.  |..|.  
plymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyv

AVLESV
 ..| .
vlmeyf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 800-1039 2.4e-16 54.6 In-house 21-221 (255) alignment 
Range on Protein: 800-1039
Range on HMM: 21-221/255.0
VTHNIASQNNDKNRSTQFLppnnhrvplknehpdyinavfingykekkafiiaespmfnTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQS-
 |.... ... |..... |                                        |  .|...|   . . .||||  .|.. | | .|.|  .  
ctehvkPekdkkrknlysl........................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekde

ALVIGEYNITLLNedKSNKYIERKFEVKNNNTG--AKQSVTQFQITNWDSTGEVKNPQTILLIieemYRTQRKRgnTSIVVHCSDTVGRSAMFCAAATTI
 |.. . |.|  .   |.. . |  |.  . .     . |. .. . |      .... || |    ..  |.    |.|||||  .|||| |  |    
klkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilni....lkvvrds..ksvvvhCstGiGrsaafvlaelvy

N-------KCKTeGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
        . .| . .|  ..|.  | .......| ||    . .|| ..
qkmirsldttet.veldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_CG42327_pd Subfamily CG42327 682-746 3.3e-16 53.9 In-house 244-309 (319) alignment 
Range on Protein: 682-746
Range on HMM: 244-309/319.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMIQTADQYIFVND
.  .||. |||| ||||||. .| |. ... |.    .||  ..  .|..| . ..| .|| |.  
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 852-1031 3.8e-16 53.4 In-house 96-280 (302) alignment 
Range on Protein: 852-1031
Range on HMM: 96-280/302.0
AESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPS-TQSALVIGEYNITLLN-EDKSNKYIERK------FEVKNNNT--GAKQSVTQFQI
   |  .|   .| .|.. ||. .| ||.  |..|. | .|.    .  |  |.| .. .. ... ... ..|       |.||...    |..|  .. 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWDSTGEVKNPQTILLIIEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGM
. |   |  |...| | |.   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||.  |   .
sawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 807-908 6.6e-16 53.0 In-house 30-138 (297) alignment 
Range on Protein: 807-908
Range on HMM: 30-138/297.0
QN--NDKNRSTQFLPPNNHRVPLKNEHP--DYINAVFINGYKEKK--AFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQ-SA
.|    ||| .. |  .. || |..  .  ||||| ..   .|..   .|.|. |. .|  .||... ...| .|||... .|.  . |. ||||..   
rnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

LVIGEYNIT
|  |.. . 
lkagdvvve
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 811-1045 8.1e-16 52.6 In-house 46-282 (312) alignment 
Range on Protein: 811-1045
Range on HMM: 46-282/312.0
KNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQ------SALVIGE
 ||  .    .  |  |  .   || | |..     . |.....|. ||. .||..      |.|..||   |.  | | .|              |  |
lnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyte

YNITLLNEDKSN-KYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAA---TTINKCK
|   .    ||. |   | . |  . || .  . ..| . |   |     .| | ..  .     |. .  .. |||  |||.  ..      ... . .
ycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhpr

TEGVIDVFQVLKSQRIQkpgSVQTILQYQGMFQIVLAYLESFETY
 . | |.| .|. .| .   ||... ||   ...|| .| |   |
kqnvkdsfvllrkdrar...svrvfpqyvyalrcvleflyskgly
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 844-1033 1.3e-15 52.1 In-house 2-198 (199) alignment 
Range on Protein: 844-1033
Range on HMM: 2-198/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSAL-VIGEYNITLLNEDKSNKYIERKFEVKNNNTGA--KQSVTQFQ
| .. .| .. |. .|  .||.|. .     |||.  .. | |     |||.|.|.    |  ..|         |    . . || |     . ....|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

ITNWD--STGEVKNPQTILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQ
.| |   .| .|     ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . .. .|. ..|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_hpo-7_pd Subfamily hpo-7 851-1038 1.4e-15 51.9 In-house 42-226 (263) alignment 
Range on Protein: 851-1038
Range on HMM: 42-226/263.0
IaespMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQS-ALVIGEYNITLLNEDKsnKYIERKFEVKN--NNTGAKQSVTQFQITNWDST
.    . .|  .|...|   . . .||||  ||.. | | .|.|  .   ... . |..  .  .  . . .  |. .  ..    . |.... . |  .
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiek

GEVKNPQTILLIIeemyRTQRKRgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAY
 ...... || |.    .  |.    |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......| .|    . .|| .
ndpelareilnil....kvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 845-1033 1.7e-15 51.7 In-house 2-197 (198) alignment 
Range on Protein: 845-1033
Range on HMM: 2-197/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSAL-VIGEYNITLLNEDKSNKYIERKFEVKNNNTGA--KQSVTQFQI
 .. .| .. |. .|  .||.|. .     |||.  .. | |     |||.|.|.    |  ..|         |    . . || |     . ....|.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWD--STGEVKNPQTILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQ
| |   .| .|     ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . .. .|. ..|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 648-750 2.4e-15 50.9 In-house 167-267 (281) alignment 
Range on Protein: 648-750
Range on HMM: 167-267/281.0
LMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINRMRQ-QRMKMIQTADQYIFVN
 .||.. .  |||  ||| .  .|.  |.|.        | ..||||||||.||.||... ||       . ||  |. ..|   |   .|| .||... 
rlithwlwkewpdwqvpessevmlkilrkirarst....ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliw

DAVLE
  .|.
kvlld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 650-749 2.4e-15 51.0 In-house 190-286 (305) alignment 
Range on Protein: 650-749
Range on HMM: 190-286/305.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQ-AEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAV
. . ..| ||| |||    . |..   |.     .| |..||||||.||||| .||.  |.. ||.     .  ... .|.||   ||.  ||.|.   .
vrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvm

L
|
l
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 649-753 2.6e-15 50.9 In-house 177-277 (312) alignment 
Range on Protein: 649-753
Range on HMM: 177-277/312.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAV
 . .| ..||||||.|.   . |..   .|..    | |.. |||||||||||.. |.  .    .    ..  .   .|..| . ...  ||...  .|
klnhyqwaswpdhgmpdscdtalrllsavkkd....kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcv

LESVT
|| . 
lefly
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 831-952 3.8e-15 50.4 In-house 12-129 (130) alignment 
Range on Protein: 831-952
Range on HMM: 12-129/130.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEevcyqYWPSTQsALVIGEYNITLLNEDKS-NKYIE-RKFEVKNN
  .|||| |.      . .. .. |. .|. .||||. .| |  .|.|   .|.||     ||| ..  |   | .|..   |.   |.|.  ..|....
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdse.Plewyeediivtltdrdefknikasnleiesd

NTGAKQSVTQFQITNWDSTGEVKN
   ..|..| |||.|| | |   |
lneshqaltmfqisnwpsdgttpn
I-set Immunoglobulin I-set domain 480-566 5.1e-15 47.0 Pfam-A 1-90 (90) alignment 
Range on Protein: 480-566
Range on HMM: 1-90/90.0
PMIEEFPNDVTSEEGCEVLLKVKFKGTPTPSFNWYHNGEPVTDDYAHELRGDG---SLLLVSVEEKHKGTYRFVANNDAGTVSQQFVLTV
| ... ..||. .|| .| |... .|.|.||..|...|.... .  .... ..   .| . .||.. .|.|. .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 688-755 3.6e-14 46.9 In-house 1-68 (69) alignment 
Range on Protein: 688-755
Range on HMM: 1-68/69.0
MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLESVTCG
|.||||.| ||||||.|| . . .   |  .||   .. ||. |  |.    .|||. ||. |..  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 649-744 4.3e-14 47.0 In-house 182-273 (301) alignment 
Range on Protein: 649-744
Range on HMM: 182-273/301.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFV
 .| | ...|.|.|||.  . . ..   .|.    .. |..||||||.||. .|.. ..  .. | .  |..   ....|..| . .||  |  ..
tvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
fn3 Fibronectin type III domain 199-272 1e-13 44.4 Pfam-A 9-84 (85) alignment 
Range on Protein: 199-272
Range on HMM: 9-84/85.0
HSKNPDAIPIVWSPPTIPNGIITVYEIRYRESTSTG-LYTITNTTNT-YYSIVGLIPNTSYTIGVRAYTSIGPGEW
.. ... . . ||||. ..| || ||..|||.....   ..|.. .|  . . || |.|.|.. |.|..  | |..
sevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 682-752 1e-13 45.9 In-house 225-295 (297) alignment 
Range on Protein: 682-752
Range on HMM: 225-295/297.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLESV
.| . ..||||||||||.|  .  |. |..  |.   |. .|.. .|.|| ...|| .|. .. ||||. .
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 690-755 1.4e-13 44.9 In-house 2-67 (69) alignment 
Range on Protein: 690-755
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLESVTCG
||||.| ||||||.|| . . .   |  .||   .. ||. |  |.   ..|.|. ||. |..  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 649-744 1.5e-13 45.3 In-house 96-196 (199) alignment 
Range on Protein: 649-744
Range on HMM: 96-196/199.0
MITQYHFTSWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMKMIQTADQYIF
 |..| |||| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  .| . ..| |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

V
.
i
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 649-744 1.5e-13 45.4 In-house 95-195 (198) alignment 
Range on Protein: 649-744
Range on HMM: 95-195/198.0
MITQYHFTSWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMKMIQTADQYIF
 |..| |||| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  .| . ..| |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

V
.
i
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 933-1039 8.5e-13 42.4 In-house 88-194 (440) alignment 
Range on Protein: 933-1039
Range on HMM: 88-194/440.0
KQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMF
 ... |..   |   |  |    .| .|...  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  |||  ||  ..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QIVLAYL
. ||  |
eavlegl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 646-777 9.2e-13 43.0 In-house 156-272 (290) alignment 
Range on Protein: 646-777
Range on HMM: 156-272/290.0
PPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAE-KEGGIDIISIINRMRQQRMKMIQTADQYIFV
 .. .| . . .| .  |.|   ..|.  . .|..    | |..|||  |. |  .. ||..| |    ..| . . .... .|.|| ..|..| .. ||
eeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafv

NDAVLesvtcgntqvdsRNARIVFNRMSKPDTK
  ...              |  | .......|.
dagiv............llaievldqfaeeete
0048179 (Phosphotyrosine protein) phosphatases II 865-1029 1e-12 43.5 In-house 23-135 (144) alignment 
Range on Protein: 865-1029
Range on HMM: 23-135/144.0
KMIDDRNVTAIVMLCHENENDEEVCYqywpstqsalvigeynitllnedksnkyierkfevknnntgakqsVTQFQITNWDSTGEVKNPQTILLIIEEMY
... . ..|... |..| |.... ..                                             ..|.. ..|.  |    .. .| ..| . 
ellkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefie

RTQRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTILQYQ
. ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|..  |..
eale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlr
0048076 (Phosphotyrosine protein) phosphatases II 912-1034 1.1e-12 43.3 In-house 23-138 (145) alignment 
Range on Protein: 912-1034
Range on HMM: 23-138/145.0
EDKSNKYIERKFEVKNNNTGAKQSVTQFQITNWDSTGEVKNPQTILLIIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVL
|   .  | . . . .. .. .. ..|.. ..|.  |.   ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......|
ellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleeal

KSQRIQKPGSVQTILQYQGMFQI
.  | | ||.|..  |.. ... 
elvrsqrpgavpnpgqlrflyef
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 652-749 1.4e-12 41.8 In-house 194-287 (310) alignment 
Range on Protein: 652-749
Range on HMM: 194-287/310.0
QYHFTSWPDHGVPEYATSILqfHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVL
  ..  ||| |||.     .   .|.  . .  .|| .||||||..|... .|... ......   .|.  ..  ....|.. |||  ||....   .
likwpnwpdrgvpdekchtv..pqrllaqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
fn3 Fibronectin type III domain 95-178 2.2e-12 40.1 Pfam-A 2-83 (85) alignment 
Range on Protein: 95-178
Range on HMM: 2-83/85.0
PVDDIIFSSVESVSMTVSWDEVPcnGRNGPITGYYFTYTSITSNT-SYTVNITGGDNrMYNLTGLIPYTNYTVSIIPYNYNMNGP
.. .. .|.| | |.|.||.. .   ..||||||  .| . ...  . ......  .  ..|||| |.|.|....  .| . .||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 648-745 3.2e-12 40.5 In-house 181-278 (302) alignment 
Range on Protein: 648-745
Range on HMM: 181-278/302.0
LMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVN
.... |..| |... ||.  ... .    . ..  ... ....    |.|| |.|..  . ... .|.    |  |.. .|.|| .......||... 
vlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvsly
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 647-750 6.1e-12 39.5 In-house 217-342 (349) alignment 
Range on Protein: 647-750
Range on HMM: 217-342/349.0
PLMITQYHFTSWPDHGVPEYATSILQFHRrIKNE----------YK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQ---QAEKE--------GGIDIIS-I
| .. |  .  |.| ..     ||||    .||.          ..     ..||||||| ||||... .|. |.     ..|           |.|| |
PyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisii

INRMRQQRMKMIQTADQYIFVNDAVLE
.| .|.||. |.|   |.|.. .|.|.
vnelrkqrismvqnlaqfiaiyealLk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 649-752 1.5e-11 38.9 In-house 117-221 (255) alignment 
Range on Protein: 649-752
Range on HMM: 117-221/255.0
MITQYHFTSWPDHGVPEYATSILQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMKMIQTADQYI
 .. |... |...  || |  ||.  . ...  |    ...||||.|.||. .|. ...  |      .  . ...| .|... .|..| . |.|  |  
tvkhysykGWieknaPelareilnilkvvrds.k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqla

FVNDAVLESV
|    ||. |
fsilmvldlv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 839-944 1.8e-11 38.1 In-house 228-328 (440) alignment 
Range on Protein: 839-944
Range on HMM: 228-328/440.0
FINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENendEEVCYQYWPSTQSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTgaKQSVTQ
 ..||  |.||| .. |.  |  .||... | ....|.||   |   .  |  |||    .. .| . .     .. |.   | .|.| ..    . . |
efegyskknafiatqmpldstvldfwrlvhdyristiimlnqln...dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykee..vheirq

FQITNW
|..  |
fevqtw
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 799-897 1.9e-11 38.3 In-house 40-154 (350) alignment 
Range on Protein: 799-897
Range on HMM: 40-154/350.0
EVTHNIasQNNDKNRSTQFLPPNNHRVPLK------------NEHPDYINAVFINGY----KEKKAF--IIAESPMFNTARNFWKMIDDRNVTAIVMLCH
.... .  .   ||| .. || .  || ||             .  ||||| ...      . .  |  | . .|. .|  .|.|.|   .|. |..|  
ilseGv..elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

ENENDEEVCYQYWPSTQ
. |.. | ||.||.  .
dvelnlekcyrYWqegs
subfamily_ptpA1_pd Subfamily ptpA1 623-705 5.6e-11 36.8 In-house 161-249 (418) alignment 
Range on Protein: 623-705
Range on HMM: 161-249/418.0
IVTVGLSPSNKLLNRFANIVVYQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY---KPT---KGPMLVHCSAGVGRTGTFMAI
.| |   |  ... |   . .      ||||..  |||| .|...  . |. . | |      |.   . |..||||||||||||| . 
lveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfcta
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 793-1034 4.2e-10 33.7 In-house 32-274 (303) alignment 
Range on Protein: 793-1034
Range on HMM: 32-274/303.0
VTQRPDEVTHNIASQNNDKNRSTQFLPPNNHRVPLKNEhpDYINAVFINGYKEKKAfIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQY
|.  | .|..|   .| |||| .. .  .  .| | .    || | ...   .||| |... |.  || .||.|| ...|  ...|  ..| |.      
vsylppsvsknqfvknmdknrfvdvicldhskvklsds..syihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv

WPSTQSALVIGEYNITLLNEDKSNKYIERKFEVKNNNTG-AKQSVTQFQITNWDSTGEVKN--PQtILLIIEEMYRTQRKRGNTSIVVHCS-DTVGRSAM
.|  |  | . |  | . .  . .     .. |     |  |  .   .  .|  .    .  |. ..  | ..    ||  ...  |. |   .||.  
fprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspk.fvkqiwqlqsvlrkysdstptvymslsgcgragt

FCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQI
|.   |.     . .  .|. ..|.  |  .  .|| . |.  .. .
falfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 961-1039 1.4e-09 32.2 In-house 218-295 (297) alignment 
Range on Protein: 961-1039
Range on HMM: 218-295/297.0
EEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
 | .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||. |.. ....||. |
leslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_hpo-7_pd Subfamily hpo-7 650-756 2.3e-09 31.5 In-house 124-231 (263) alignment 
Range on Protein: 650-756
Range on HMM: 124-231/263.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMKMIQTADQYIF
...| .. |...  || | .||.  .  .|  |    .. ||||.|.||.  |  ...  |      .  . ...| .|... .|..| . |.|  |  |
vkhysykgWiekndpelareilnilkvarns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf

VNDAVLESVTCGN
    ||. |   .
silmvLdfvlnnf
0038934 (Phosphotyrosine protein) phosphatases II 645-741 6.7e-09 31.1 In-house 71-166 (194) alignment 
Range on Protein: 645-741
Range on HMM: 71-166/194.0
QPPLMIT---QYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMglqqaEKEGGIDIISIINRMRQQRMKMIQTADQ
 | ..     .|.   .||.|..     .|.| . ..  ..  ..|  .||| ||.|||||. |  .      .  |..    |...|. | ..|.. |.
dpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdy

Y
.
l
subfamily_eak_pd Subfamily eak 792-949 8.3e-09 29.3 In-house 45-194 (332) alignment 
Range on Protein: 792-949
Range on HMM: 45-194/332.0
QVTQRPDEVTHNIASQNNDKNRSTQFLPpNnhrvplKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQ
..|.| ..|  |.      .    .. .        . ..  ||||  ..  .  . .|..  .  .    ||.|. ...  |||.| .. |.. |   .
setarleavnrnvvkivpydrylvrlts.s......qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdk

YWPSTQ-SALVIGEYNITLLNEDKSNKYIERKFEVKNNNTGakQSVTQFQITNWDSTGE
|.|      |  | ....  .  | |..  |..|..  |      |  ...  |  |  
yfpdktreelkfGildverkefvkrniletrllelskGnet..hrvlhykvfGwtettl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 810-888 1.7e-08 28.3 In-house 48-125 (347) alignment 
Range on Protein: 810-888
Range on HMM: 48-125/347.0
DKNRSTQFLPPNNHRVPLKNEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLcHENENDEEV
 .. .   | |.. .    ..   ||||  |.  . .| .|... |. .| |.||||.   .|| .| .  |  .|| .
lidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti.fepikdeai
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 847-1039 4.7e-08 26.0 In-house 115-309 (346) alignment 
Range on Protein: 847-1039
Range on HMM: 115-309/346.0
KAFIIAESPMFNT---ARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQSALVIGEYNITLLNEDKSNKYIERKFEVKNNntGAKQSVTqFQITN
. .|.|. | ..      .|| || . ..  . ..  ..   .     .          |   |     | |    |   ||  .  |  .||   |.  
hklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpe..gnsdsvi.cqvhh

WDSTGEVKNPQTILLIIEEM--YRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAYL
      ...|   | ||  .  . ....  |. . |      ||.  |  |  .||.       ......|. . |.||.|... || ... ||. |.
hapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
Ig_2 Immunoglobulin domain 486-566 9.7e-08 24.0 Pfam-A 8-80 (80) alignment 
Range on Protein: 486-566
Range on HMM: 8-80/80.0
PndVTSEEGCEVLLKVKFKGTPTPSFNWYHNGEPVTDDYAHelrgdgsLLLVSVEEKHKGTYRFVANND-AGTVSQQFVLTV
|  .. .||. | |  ...| |||.. ||..||...   .        |.. .|.....|||. .| |.  ...|. . .||
p..tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsvevtv
subfamily_PTPDC1_pd Subfamily PTPDC1 653-746 2.5e-07 25.3 In-house 85-170 (182) alignment 
Range on Protein: 653-746
Range on HMM: 85-170/182.0
YHFTSWPDHGVPEYaTSILQFHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAekeggIDIISIINRMRQQRMKMIQTADQYIFVND
..  .|.|.||.   ..||.  . ..   .  .| . ||| || ||||  .|  .  ..      ..    |. .|..| | ||| .|  .|..
vynfgwkDygvasl.eriLdivkvvafalq..egkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_CG42327_pd Subfamily CG42327 968-1038 2.5e-07 24.7 In-house 243-314 (319) alignment 
Range on Protein: 968-1038
Range on HMM: 243-314/319.0
RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTILQYQGMFQIVLAY
..  .  .|||||| |||. .  |.  .|.. ..    .|. |.. | | ..  .|.|. ||. .....  |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 807-951 4.2e-07 23.7 In-house 33-178 (332) alignment 
Range on Protein: 807-951
Range on HMM: 33-178/332.0
QNNDKNRSTQFLPPNNHRVPLK--NEHPDYINAVFINGYKEKKAFIIAESPMFN-TARNFWKMIDDRNVTAIVMLCHENEND-EEVCYQYWPSTQSALVI
.| | ||  ..   .  || |   . . |. || ...|| .| |.|.|..|. . |   ||.|. .|. . |...   .|..  .  |.         ..
nnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksfl

GEYNITLLNEDKSNKYIERKFEVKnnnTGAKQSVTQFQITNWDSTGEVK
 |.    |.| . .  | |||  .    ..|. .  . |   |   | .
hefgaksleecelkakicrkfwpe...krskkdfpalsiqasddhseth
Filo_glycop Filovirus glycoprotein 910-976 7.8e-07 16.0 Pfam-A 191-259 (364) alignment 
Range on Protein: 910-976
Range on HMM: 191-259/364.0
LNEDKSNKYIERKFEVKNNNTGAKQSVTQFQI--TNWDSTGEVKNPQTILLIIEEMYRTQRKRGNTSIV
 .|| ..||.  . | . ...|...| . |..  |..    . . ||... . |....|...   |  .
mtedstskYatstleyevedfGteeseiLfevdnttyvqlersltPqfLvqlnetikltnkrsnttgkl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 828-897 8.2e-07 22.7 In-house 86-157 (349) alignment 
Range on Protein: 828-897
Range on HMM: 86-157/349.0
KNEHPDYINAVFIN--GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENDEEVCYQYWPSTQ
     ||||| ...   .. .| .|    |.  |  .|.|.|   .|  .. | ...|.. | |..||   .
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels
PTEN_1 652-702 1.7e-06 22.9 In-house 96-147 (196) alignment 
Range on Protein: 652-702
Range on HMM: 96-147/196.0
QYHFTSWPDHGVPEYAtSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTF
.|.  ...|||.|  . ... . ..... ..  | ..  |||| ||.||.|| 
eylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtv
Ig_3 Immunoglobulin domain 486-553 2.9e-06 19.4 Pfam-A 9-75 (75) alignment 
Range on Protein: 486-553
Range on HMM: 9-75/75.0
PNDVTSEEGceVLLKVKFKGTP-TPSFNWYhNGEPVTDDYAHELRGDGSLLLVS-VEEKHKGTYRFVANN
...|||...  | |    .|.| .|.. || ...|  ..  . ... .| | .| | ... |||. ||.|
sptvtsggn..vtLtCsaeggpppptisWy.ietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 934-996 2.9e-06 21.3 In-house 215-286 (350) alignment 
Range on Protein: 934-996
Range on HMM: 215-286/350.0
QSVTQFQITNWDSTGEVKNPQTILLIIE--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAATTI
  | |.|. ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....    .
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDsll
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 653-752 4.2e-06 20.6 In-house 176-279 (303) alignment 
Range on Protein: 653-752
Range on HMM: 176-279/303.0
YHFTSWPDH-----GVPEYATSILQFHRRIKnEYKPTKGPMLVHCSaGVGRTGTFMAIDMG-LQQAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVND
.|. .||       | |..   | |    ..  | ... .. .  | |.||.|||  ..   |   ...  .|..  .. .|. |.. .|   |. .|  
hhykawphnsipsdgspkfvkqiwqlqsvlr.kysdstptvymsls.gcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvyt

AVLESV
 . | |
llaehv
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 804-853 9e-06 19.8 In-house 44-94 (95) alignment 
Range on Protein: 804-853
Range on HMM: 44-94/95.0
IASQNNDKNRSTQFLPPNNHRVPLKNE-HPDYINAVFINGYKEKKAFIIAE
 .  |  |||  . .| .  || |      |||||.|..||  |...| |.
sseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq
subfamily_PTPRD_pd Subfamily PTPRD 587-645 9.3e-06 19.5 In-house 4-61 (564) alignment 
Range on Protein: 587-645
Range on HMM: 4-61/564.0
LIPVEQFGEFVANGHAKGNEGFRNQFMMLDRGeSEHIVTVGLSPSNKLLNRFANIVVYQ
 |||... |.||. .|...  | ...  ...| ... ...   | ||  ||.|||| | 
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYd
subfamily_eak_pd Subfamily eak 681-759 9.7e-06 19.2 In-house 233-312 (332) alignment 
Range on Protein: 681-759
Range on HMM: 233-312/332.0
YKPTKGPMlVHCSAGVGRTGTFMAIDMGLQ--QAEKEGGIDIISIINRMRQQRMKMIQTADQYIFVNDAVLESVTCGNTQV
  |.  |. . .. |  |.|.|. ||. ..  .. |.    .  .| .....|.. . .| |. |. ..||. .   | ..
tppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrl