Gene PTPRD-14 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP067_AA protein Get Run
AqueP067_AA_4-216 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-146 2.1e-79 261.4 In-house 28-173 (290) alignment 
Range on Protein: 1-146
Range on HMM: 28-173/290.0
MLDSGESEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKE
||||||||||||||||.|||||||||||||||||||||||.|||.||..|||||||||.|....|||||||||||||||||.|||||...||||.||..|
mldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniie

EGKVKCQQYWPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDC
|||||||||||.||||.||.||..|..|. |..|. ||..|| |. 
egkvkCqqYWpdsdtkaygefsikllneetlneyierklevknkns
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-216 1.1e-77 255.9 In-house 28-259 (287) alignment 
Range on Protein: 1-216
Range on HMM: 28-259/287.0
MLDS-GESEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmsghnDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVK
.|.. ...|. ||......|| .||...|.|.|..|. |.      .. ..||||..|. |......|....|..||...||.||.... ..|||... |
vleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqek

EEGKVKCQQYWPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKD---------CYEI---------NLSQ---IILFNQIKNEYKPTKGPMLVHCSAG
|. . .| ||||....  .|.....| .|.  ..|..||..|| |.          |.|         .  |   ... ...|...|.......||||..
endeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdt

VGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMK
|||...|.|..........||.||........|.|...
vGrsamfcaaattinkckteGviDvfqvlksqriqkpg
0051299 (Phosphotyrosine protein) phosphatases II 7-215 2.8e-69 229.1 In-house 37-266 (288) alignment 
Range on Protein: 7-215
Range on HMM: 37-266/288.0
SEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGhnDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKC
  .|....| | |.  ||. .|. ||..|. |....|  . .. |||| ||. | .. ..|||||| .||. |||...|......|||.|.. | |..||
pdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekc

QQYWPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVK----DCYEINLSQIILFN-------------------QIKNEYKPTKGPMLVHCSAGVGRTG
 ||||..... ||...||| .|. | |||||...|. .     . |    ... .                    .... .....||..|||||||||||
aqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtg

TFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
|| |.|. |.| |||||.|. ....|.|.||.
tfialdllleqlekeggvdvleavkrlreqRp
0050432 (Phosphotyrosine protein) phosphatases II 7-215 8.4e-69 227.6 In-house 56-279 (308) alignment 
Range on Protein: 7-215
Range on HMM: 56-279/308.0
SEHTVTVGLTPSNKLLNRFANIVVYDDNRITLrpmsghnDCPHEYINACYIKDY--SNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKV
  .. .|.| | || .||. .|. || .|. |       | .. |||| |.. |   .. ..|||||| .||. |||...|......|||.|.  | |..
plleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengre

KCQQYWPNS---DTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCYEINLSQIILFNQIKNEYKPT-----------------KGPMLVHCSAGVGRTGT
|| ||||..   ... ||.|.||| .|. | |||||..... ... |    ... .   ..   |.                 .||..||||||||||||
kcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGt

FMAIDMGLQQAEKEGGIDIISIINRMRQQRM
| |.|. |.| |||||.|. ......|.||.
fialdllleqlekeggvdvfeavkklReqRp
0040438 (Phosphotyrosine protein) phosphatases II 8-215 2e-67 223.0 In-house 32-256 (317) alignment 
Range on Protein: 8-215
Range on HMM: 32-256/317.0
EHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGhnDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQ
 .| .|.. | || .||. .|. ||..|. | |..|  | .. |||| |.. .. . ..|||||| .||. |||...|.... .|||.|. .| |..||.
ldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekca

QYWPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHV-------------------KVKDCYEINLSQIILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAI
||||. .|. ||.|.||| .|. | ..|.|...|                      .. .   . . ....... ... .||.|||||||||||||| |.
qYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaa

DMGLQQAEKEGGIDIISIINRMRQQRM
.. |.| |||||.|. ......|.||.
ylmleqlekeggvdveeavkelreqRp
0046845 (Phosphotyrosine protein) phosphatases II 9-215 1.3e-66 220.2 In-house 18-254 (284) alignment 
Range on Protein: 9-215
Range on HMM: 18-254/284.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHnDCPHEYINACYIKDY-----SNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGK
....|.| | |. .||. .|..||..|. |....|. .  ..|||| |.. |      .. ..||||||..||. |||...|......|||.|.  | |.
lslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengr

VKCQQYWPNSD-TKDYGPFSVTLSDEQLLTDYTVRKMHVKVKD-CYEINLSQIILFNQIKNEYKP---------------------TKGPMLVHCSAGVG
.|| ||||... .. ||.|.||| .|.   |||||.. .. .. . |    ... . .. .   |                     ..||..||||||||
ekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg

RTGTFMAIDMGLQQAEKEG---GIDIISIINRMRQQRM
||||| |.|. |.| ||||   |.|. ....|.|.||.
RtGtfialdllleqlekeglllgvdvleavkrlreqRp
0036941 (Phosphotyrosine protein) phosphatases II 8-215 4.2e-66 218.6 In-house 28-257 (297) alignment 
Range on Protein: 8-215
Range on HMM: 28-257/297.0
EHTVTVGLTPSNKLLNRFANIVVYDDNRITLrpmsghNDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQ
  . .|.| | |. .||. .|. ||..|. |      .| .. ||||.|.. |. ....|||||| .||. |||...|......|||.|.. | |..||.
lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

QYWPNS--DTKDYGPFSVTLSDEQL--LTDYTVRKMHVKVKDCYEINLSQIILFNQIKNEYKP---------------------TKGPMLVHCSAGVGRT
||||.   ... ||.|.||| ...   |.|||.|...|. ... |    ... .  .     |                      .||.||||||||||.
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

GTFMAIDMGLQQAE---KEGGIDIISIINRMRQQRM
||| |.|. ||| |   ||||.|| .... .|.||.
gtfiaadlmlqqledklkeggvdileavkklReqRp
0047943 (Phosphotyrosine protein) phosphatases II 7-215 1.3e-65 216.9 In-house 26-252 (273) alignment 
Range on Protein: 7-215
Range on HMM: 26-252/273.0
SEHTVTVGLTPSNKLLNRFANIVVYDDNRITLrpmsghNDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKC
 ..| .|.| | || .||. .|. ||..|. |      .| .. |||| |.. |  . ..|||||| .||. |||...|......|||.|.. | |..||
plltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekc

QQYWPNSD---TKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCYEINLSQIILFNQIKNEYKP---------------------TKGPMLVHCSAGVGRT
 ||||..    .. ||.|.||| .|.   |||||.. .. ... |    .....  . .   |                      .||..||||||||||
aqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRt

GTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
||| |.|. |.| |||||.|. ......|.||.
gtfialdllldqlekeggvdvleavkllrsqRp
0043336 (Phosphotyrosine protein) phosphatases II 9-215 7.8e-64 211.1 In-house 35-257 (278) alignment 
Range on Protein: 9-215
Range on HMM: 35-257/278.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDcpHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQ
 | ...| | || .||. .|. || .|. | ...|..|  . |||| |.. |. . ..|||||| ..|. |||...|......|||.|. .| |.|||.|
dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaq

YWPnSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCYEINLSQIILF-------------------NQIKNEYKPTKGPMLVHCSAGVGRTGTFMAID
||| .... ||.|.||| .|. | |||||...|. . . |    ... .                   ..... ... .||.||||||||||||||.|..
Ywp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialy

MGLQQAEKEGGIDIISIINRMRQQRM
. |.|.|||||.|. ......|.||.
llleqlekeggvdleeavkelreqRp
0039614 (Phosphotyrosine protein) phosphatases II 11-215 2.5e-62 206.3 In-house 48-269 (297) alignment 
Range on Protein: 11-215
Range on HMM: 48-269/297.0
VTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHnDCPHEYINACYIKDYSN-QYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKvKCQQY
 ...| | || .||. .|. ||..|. | |. |. | .. |||| |.. |.  . ..|||||| ..|. |||...|......|||.|. .| |. ||.||
ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqy

WPNSDTkDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCY---------------EI-NLSQIILFNQIKNEYK---PTKGPMLVHCSAGVGRTGTFMAIDM
||.. .  ||.|.||| ... | .||||...|. ...                   .|.... | .. .|.    | .||.|||||||||||||| |...
wpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaayl

GLQQAEKEGGIDIISIINRMRQQRM
 |.| |||||.|. ......|.||.
mleqlekeggvdvleavkelreqRp
0045450 (Phosphotyrosine protein) phosphatases II 9-215 6.9e-61 202.0 In-house 45-284 (307) alignment 
Range on Protein: 9-215
Range on HMM: 45-284/307.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHnDCPHEYINACYI--------KDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKE
.. ...| | || .||. .|. ||..|. | ...|. . .. |||| |.        . | .. ..|||||| ..|. |||...|.... .|||.|. .|
geysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve

EGKVKCQQYWPNSD-TKDYGPFSVTLSDEQLLTDYTVRKMHVKVK------------------DCYE-INLSQIILFNQIKNEYK---PTKGPMLVHCSA
 |..|| ||||... .. ||.| ||| .|. | .||||...|. .                  |     ...... | .. ...    | .||.||||||
lgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsa

GVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQRM
||||||||.|... |.| ||||    .|. ......|.||.
GvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRp
0040439 (Phosphotyrosine protein) phosphatases II 10-215 5.6e-60 198.3 In-house 2-226 (249) alignment 
Range on Protein: 10-215
Range on HMM: 2-226/249.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGhnDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQY
...|.| | || .||. .|. || .|. | ...|    .. |||| ||. |  . ..|||||| ..|. |||...|.... .|||.|. .| |..||.||
eysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCYEINLSQIILFNQIKNEYKP---------------------TKGPMLVHCSAGVGRTGTFMAI
||..... || |.||| ... . |||||..... . . |    . | .  .     |                     ..||.|||||||||||||| |.
wplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DMGLQQAEKEGGIDIISIINRMRQQRM
.. |.| |||.|.|. .... .|.||.
ylmleqlekelgvdleeavkllrsqRp
0045098 (Phosphotyrosine protein) phosphatases II 9-216 9.1e-60 197.7 In-house 23-252 (278) alignment 
Range on Protein: 9-216
Range on HMM: 23-252/278.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITlrpmsghndcphEYINACYIKDYsnQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQ
 ..|..| ..|. .||. .|. || .|.             .|||| ||. |  . ..||||||  .|. |||...|......|||.|...| |..|| |
seitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVK-----DCYEINLSQ--------------------IILFNQIKNEYK-------------PTKGP
|||..... ||.|.||| .|. | |||.|...|        |... .. .                    . |...|.. .|             . .||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

MLVHCSAGVGRTGTFMAIDMGLQQAekEGGIDIISIINRMRQQRMK
.|||||||||||||. |... |..   |||.|. .... .|.||. 
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpg
0042113 (Phosphotyrosine protein) phosphatases II 13-215 6.3e-59 194.7 In-house 3-223 (245) alignment 
Range on Protein: 13-215
Range on HMM: 3-223/245.0
VGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCPheYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPN
|.| | || .||. .|. ||..|. | |..|..|..  ||||.|.. |    ..|||||| ..|. |||...|.... .|||.|.  | |.|||.||||.
vallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

SDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVK-DCYEIN-----------------LSQIILFNQIKNEYKP--TKGPMLVHCSAGVGRTGTFMAIDMGL
.... || |.||| .|. | |||||...|. . | .. .                 |.... | .. ...     .||.||||||||||||||.|... |
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

QQAEKEGGIDIISIINRMRQQRM
.|.|||.|... ... ..|.||.
eqlekelgvsleeavkelrsqRp
DSPc_SM00195 5-215 6.7e-58 191.4 In-house 12-242 (263) alignment 
Range on Protein: 5-215
Range on HMM: 12-242/263.0
GESEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHndCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKV
 .|....| .  ..||  ||. ||..||..|. | .  ..   ...|||| ||| .... .||||||| ..|. |||...|.|...||||.|. .|.|| 
stspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengke

KCQQYWPNS--DTKDYGPFSVTLSDEQLLT-DYTVRKMHVKVKDC------YEIN-------------LSQIILFNQIKNEYKPTKGPMLVHCSAGVGRT
||..|||..  .....| .||.| ...    ....|..... ...      . ..              | . |....|.... ..||..||||||||||
kcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRt

GTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
|||..||. |.. |.|  .|| .|....|.||.
gtfvtidiilskleeekkvdifeivkelRkqRp
PTPc_SM00194 5-215 6.7e-58 191.4 In-house 12-242 (263) alignment 
Range on Protein: 5-215
Range on HMM: 12-242/263.0
GESEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHndCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKV
 .|....| .  ..||  ||. ||..||..|. | .  ..   ...|||| ||| .... .||||||| ..|. |||...|.|...||||.|. .|.|| 
stspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengke

KCQQYWPNS--DTKDYGPFSVTLSDEQLLT-DYTVRKMHVKVKDC------YEIN-------------LSQIILFNQIKNEYKPTKGPMLVHCSAGVGRT
||..|||..  .....| .||.| ...    ....|..... ...      . ..              | . |....|.... ..||..||||||||||
kcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRt

GTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
|||..||. |.. |.|  .|| .|....|.||.
gtfvtidiilskleeekkvdifeivkelRkqRp
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 6-215 9.4e-58 190.5 In-house 34-259 (288) alignment 
Range on Protein: 6-215
Range on HMM: 34-259/288.0
ESEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDcpHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVK
|....||.|  . |.  ||. ||. || .|. |. .   ..   .|||| ||... .. .|||||||. .|. |||.|......  |||.|.. |.|| |
ektksvtagrlavnakknRyrnilpyDekrvklkkleeeag..aDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktk

CQQYWPNSDT-KDYGPFSVTLSDEQLLTDYTVRKMHVKvKDCYEINLSQ------------------IILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFM
|..|||..|. | || . ||| ... |.|...||. .. |.  |... |                  . | .|.|.  .   ||..|||||||||||||.
CeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFi

AIDMGLQQAEKEGGIDIISIINRMRQQRM
|.|. ... |.|  ||........|.||.
aldalidaveeedyiDvagtvaklRkqRa
0037934 (Phosphotyrosine protein) phosphatases II 12-216 3.8e-53 175.9 In-house 3-222 (243) alignment 
Range on Protein: 12-216
Range on HMM: 3-222/243.0
TVGLTPSNKLLNRFANIVVYDDNRITLrpmsghNDcpHEYINACYIKDYSNqyqYIATQGPVSNTLVD----FWQLIWQERSPIIVMITNVKEEGKVKCQ
...| | |.  ||. .|. ||..|. |      ..  . |||| .|. . .   .|||||| ..|. |    ||...|.... .|||.|. .| |..|| 
siallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPnsDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCYE-------------------INLSQIILFNQIKNE---------YKPTKGPMLVHCSAGV
||||  ... ||.|.||| .|. | |||||..... .|...                    . .... | .. .|         . ...||.||||||||
qywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTFMAIDMGLQQAekegGIDIISIINRMRQQRMK
|||||. |... |..     |.|. ......|.||. 
gRtGtliaaylmllll....gvdleeavkllreqRpg
subfamily_PTPRD_pd Subfamily PTPRD 7-145 2.6e-51 169.9 In-house 36-172 (564) alignment 
Range on Protein: 7-145
Range on HMM: 36-172/564.0
SEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKC
...|...   | ||  ||.|||| || .|. |... |....  .|||| .|. | .. .|||||||...|. |||...|...| .|||.|...|.|||||
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkc

QQYWPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKD
..|||...|. || . |||..|. |.||..|.. .| |.
hkYWPekgtetygeltVtleeeeeladyeirtfklkkkk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 13-215 1.6e-50 166.6 In-house 27-246 (283) alignment 
Range on Protein: 13-215
Range on HMM: 27-246/283.0
VGLTPSNKLLNRFANIVVYDDNRITLRPMSGhndcphEYINACYIK---DYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQY
.  .  ||  ||. .||..| .|. |.. |       .||||..|    .| .. .||..|.|. .| ||||.....|.   |||.|...|. ..|| ||
iasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPNSDTKDYGPFSVTLSDEQLLTDYTVRKM---------------HVKVKDCYEINLSQII--L--FNQIK-NEYKPTKGPMLVHCSAGVGRTGTFMAID
||.  ..|||.| ||| .|     ......               | .| |  |..   ||  |  ||... .  .  |||..||||.|.|||..|.|. 
WPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaas

MGLQQAEKEGGIDIISIINRMRQQRM
  ...|  |  .|. .... ||.|||
asvkdaltesvvdvfavvkimreqrm
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 7-147 3.7e-48 158.7 In-house 28-170 (301) alignment 
Range on Protein: 7-147
Range on HMM: 28-170/301.0
SEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKC
.... ||||. .|| |||| ||.|||||||.|.|..  . | .||||| ||..||.. ..||.|||. .||||||.|||||.   |||.|| ||. | ||
edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskc

QQYWPNSD--TKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCY
.||||||.  ....|||.|||..|| . |...|.. ||..|  
eqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgs
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 8-145 2.3e-45 150.1 In-house 35-172 (305) alignment 
Range on Protein: 8-145
Range on HMM: 35-172/305.0
EHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNdcPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQ
|... || .  ||  ||...|...||.|| |.. . ..   ..||||.|.. |... .||..|||. ||..|||.||..|.   |||.|...|.|| ||.
eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCr

QYWPNSDTK--DYGPFSVTLSDEQLLTDYTVRKMHVKVKD
||||.| |.  ..|.|||.|..|.  .||. ||... ..|
qYWpesktekkefgefsvelksektasdyieRklkisied
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 7-147 3.5e-45 149.4 In-house 34-172 (318) alignment 
Range on Protein: 7-147
Range on HMM: 34-172/318.0
SEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKC
.. | .  |.| ||  ||.|||. ||. |. |....|...   .|||| ||  | .. .|||.|.|...|. |||...|.  | .|||.|...|.||.|.
etvtslkslepvnkaknryanilaydhtrvkLqmlegeegs..DyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakv

QQYWPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCY
..|||..... ||   |.|..|  |.||..|...|. ... 
hryWPskgsrsygklvvelkeevelsdyvlrefkvtrteee
subfamily_PTPRG_pd Subfamily PTPRG 10-143 2e-43 143.4 In-house 38-170 (563) alignment 
Range on Protein: 10-143
Range on HMM: 38-170/563.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCpHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQY
...    |.||  ||  ||| ||  |..|.|..|...  ..|||| ||. |  . ..||||||. .|. |||..||.... |||||||..|.|. ||..|
daehsqkpenkrKnRylnivaydrsRvklsplpgkkkk.lDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvY

WPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKV
||. ....|| ..||| .|. |. ||||.. .| 
WPkdesetygalqvtlieeevlalytvrtlvikn
subfamily_PTPRB_pd Subfamily PTPRB 7-145 1.9e-42 140.3 In-house 39-176 (293) alignment 
Range on Protein: 7-145
Range on HMM: 39-176/293.0
SEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDcpHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKC
....|..  .. |.  ||. ||. || .|. | .......   .|||| ||..|. . ..||||||. .|. |||...|...| ||||.|.. |.|||||
kdqavkaaelavnraknrytnilpydhsrvkLaalkdesg..sDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkC

QQYWPNS-DTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKD
..|||.  ..  ||  .|||  |. |.|...|..... ..
eeYWPadeepvlyGdikvtlvaeeeledwvirelkiekek
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 8-145 6.8e-42 138.7 In-house 45-180 (298) alignment 
Range on Protein: 8-145
Range on HMM: 45-180/298.0
EHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQ
|.. .|. .|.||  ||.|.|. .|  |. |. ... ...  .|||| ... |...  .||||.|. .|..|||.....| .  |||.||..| .|.|..
eeekevarkpenkkkNRyadiialdssRvvLekedadees..dYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyh

QYWPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKD
.|||.. .. || ..|.|  ..  .|..|||..|. |.
kywPdegketygeitvsllskeefadlivrklkvskkk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 16-215 2.3e-41 136.5 In-house 40-256 (515) alignment 
Range on Protein: 16-215
Range on HMM: 40-256/515.0
TPSNKLLNRFANIVVYDDNRITLRPMsghNDCP-HEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPN--
   |   ||. ||. || .|. |  .   || | ..|.|| ||. . |.  |||.|||   .. |||.|..||.   |.|.|. ||. |.|| .|||.  
eeinfkknryknilPydsvrvklevi...ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

SDTKDYGPFSVTLSDEQLLTDYTVRKMHV-KVKDCYEIN----------------LSQIILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQA
.|.  .| ..| |   .  |. . ||..| | .|.  .                  | . |  ..| .    . |...|||||||||| ...||  . .|
gdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

EKEGGIDIISIINRMRQQRM
..   .|.  ... .||.|.
kttrmvdvfnfvtnirqkrp
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 7-145 6.2e-41 135.5 In-house 37-172 (319) alignment 
Range on Protein: 7-145
Range on HMM: 37-172/319.0
SEhTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKC
.. |..   .. ||  ||. ||. ||  |..| .. | ..   .|||| .|  | .. ..||||.|..||. |||...|.|.| |.||.|...|..|||.
nd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegs..dyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvkl

QQYWPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKD
..|||. . ..|| . ||| .|. | || .||.... | 
kkywpeenfeeyGrlivtleeeeeledyiirklklnkks
subfamily_PTPN6_pd Subfamily PTPN6 12-144 3.2e-40 133.0 In-house 47-179 (306) alignment 
Range on Protein: 12-144
Range on HMM: 47-179/306.0
TVGLTPSNKLLNRFANIVVYDDNRITLRpmsGHNDCPHEYINACYIKD--YSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQY
. |  |.||  ||. ||. .|..|..|.    ..   ..|||| |||.   ... .|||||| ...|. |||...||| | .|||.|.  | || || .|
kegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarY

WPNSD-TKDYGPFSVTLSDEQLLTDYTVRKMHVKVK
||..  ...||  |||  .|. |.||..|...|. |
WPdeeekeeyGkisvtnvseksladYilRelsvskk
subfamily_PTPRA_pd Subfamily PTPRA 5-146 4.3e-40 132.6 In-house 44-184 (330) alignment 
Range on Protein: 5-146
Range on HMM: 44-184/330.0
GESEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKV
|. . |. .     ||  ||. ||. || .|. | ...|...   .|||| .|. | .. ..||.||| ..|. |||..||. .|  |||.|..||  . 
gpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvees..dyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkee

KCQQYWPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVK-VKDC
||.||||.  .  ||   |.. ||..| ||||||. |. . | 
kcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpda
Y_phosphatase Protein-tyrosine phosphatase 19-145 2.9e-39 130.2 Pfam-A 1-127 (235) alignment 
Range on Protein: 19-145
Range on HMM: 1-127/235.0
NKLLNRFANIVVYDDNRITLRPMSGHNDcpheYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWP--NSDTK
||  ||. .|..||..|. |.  .|..|    |||| |.| |... ..||||||...|. |||...|||.. .|||.|...|.|..||.||||  .....
nkkknRykdilpydktrvklkgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

DYGPFSVTLS-DEQ-LLTDYTVRKMHVKVKD
 || ..|.|  .|.   ..||.||...| |.
tygdikvelkekekedekeytlrklelkkkk
Y_phosphatase Protein-tyrosine phosphatase 19-145 2.9e-39 130.2 In-house 1-127 (235) alignment 
Range on Protein: 19-145
Range on HMM: 1-127/235.0
NKLLNRFANIVVYDDNRITLRPMSGHNDcpheYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWP--NSDTK
||  ||. .|..||..|. |.  .|..|    |||| |.| |... ..||||||...|. |||...|||.. .|||.|...|.|..||.||||  .....
nkkknRykdilpydktrvklkgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

DYGPFSVTLS-DEQ-LLTDYTVRKMHVKVKD
 || ..|.|  .|.   ..||.||...| |.
tygdikvelkekekedekeytlrklelkkkk
subfamily_Ptp69D_pd Subfamily Ptp69D 5-145 3.8e-39 129.6 In-house 34-172 (307) alignment 
Range on Protein: 5-145
Range on HMM: 34-172/307.0
GESEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKV
 |.... .|.    |.| ||. .|. .|..|. |... |..|   .|||| .|| | .. ..|| |.|| .|. |||..|..  . .|||..|..|  . 
reidkstkvsekkenalknRyedikafDktRvkLkkingkeds..dYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrk

KCQQYWPNSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKD
||..|||. |.. ||   |.| .|.  .||. |...|  |.
kcakYWpiedevqygdilvklvseekhsdyiiReldvskkk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 13-142 1.1e-38 127.8 In-house 3-129 (250) alignment 
Range on Protein: 13-142
Range on HMM: 3-129/250.0
VGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVkCQQYWPN
|.  |.||  ||.|.|. .|  |. | . .| ...  .|||| ... |...  .||||||...|..|||.....| |  |||.||.||..|. ..|||| 
vakkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

SDTKDYGPFSVTLSDEQLLTDYTVRKMHVK
  .. ||   |.| ...  .|||.||. . 
ekaekyGdvtvsllskeefadytkrklkls
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 8-154 3.1e-38 126.5 In-house 30-175 (281) alignment 
Range on Protein: 8-154
Range on HMM: 30-175/281.0
EHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQ
..| |   .. |.| ||. ||| ||  |... | . ....  .|||| ... |... .|||||||| ..||.|||..|...  .|||.|.  |.||.|| 
dntataskadenvlknrYsnivaYDatrvkvtpneenknt..DYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkCh

QYWPNSD-TKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCYEINLSQI
.|||. . .  || . |.   |.  . |  ||.... ... . ...|.
rYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveql
subfamily_PTPN12_pd Subfamily PTPN12 9-145 2e-37 123.7 In-house 30-167 (290) alignment 
Range on Protein: 9-145
Range on HMM: 30-167/290.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNdcPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQ
.. ..| ...|.  ||. .|. || .|..|. .....    .|||| .||  ... .|||.|||...|| |||..||. .  |.||. .. | || ||..
ysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPNSDTK--DYGPFSVTLSDEQLLT-DYTVRKMHVKVKD
|||..  .   .|.|.|||..|. .. |...| ..|....
YWpeegeeelefgefevtleeekavdddflirtLkveaqk
subfamily_PTPRK_pd Subfamily PTPRK 18-143 2.7e-36 120.0 In-house 42-164 (314) alignment 
Range on Protein: 18-143
Range on HMM: 42-164/314.0
SNKLLNRFANIVVYDDNRITLRPMSGhnDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNsDTKD
 |.  ||. .|. ||  |..| .. |  |   .|||| .|  | .  ..|.||||. .|. |||.|...|..  |||.|...|.|.||| .|||. ||. 
enreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe.dtev

YGPFSVTLSDEQLLTDYTVRKMHVKV
||.. |.| . .||... || . |. 
ygdikvelvetellaelvvrifrvek
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 18-145 6e-36 118.9 In-house 2-127 (237) alignment 
Range on Protein: 18-145
Range on HMM: 2-127/237.0
SNKLLNRFANIVVYDDNRITLRPMSGHndcpHEYINACYIKDYSN-QYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSDT-
 ||. ||..|||.|| .|. |.   .      .||||.|.|..     .|||.|||. ..  ||||..|||.  .|||.| . |  ..|| .|||..|  
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

KDYGPFSVTLSDEQLLTDYTVRKMHVKVKD
. || ..|.|  .. ..||||| . . .. 
aaygvltvslkkkeefsdytvrslllskrl
subfamily_PTPN9_pd Subfamily PTPN9 10-143 2.8e-35 116.8 In-house 33-166 (297) alignment 
Range on Protein: 10-143
Range on HMM: 33-166/297.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNdcPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQY
|...  ...|   ||..... ||. |..|  .....    .|||| ..  | ..  .||||||. .|  |||...|...  .|||.| | |.|..||.||
tflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqy

WP--NSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKV
||  . .....| .||.  . .   ||.||....| 
Wpleeessaefgdlsvsnveveeeedykvrvleikn
subfamily_PTPN3_pd Subfamily PTPN3 9-145 5.6e-35 115.6 In-house 31-166 (280) alignment 
Range on Protein: 9-145
Range on HMM: 31-166/280.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmsghnDCPHEYINACYIKDYSNQ----YQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKV
 ....   | |   ||. .|. ||. |..|.      . . .|||| |..  ..      .|||||||...|  ||||..|...| .|||.|.. |.|.|
laisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

KCQQYWPN-SDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKD
|| ||||. .|. .|| |||... |.  . | .|.. .| |.
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdke
0049772 (Phosphotyrosine protein) phosphatases II 7-215 5.9e-35 116.9 In-house 34-255 (314) alignment 
Range on Protein: 7-215
Range on HMM: 34-255/314.0
SEHTVTVGLTPSNKLLNRFANIVVYDdNRITLrPMSGHNDcpHEYINACYIKDYsnqYQYIATQGPVSNTLVDF----------WQLI--WQERSPIIVM
.|.|..|.  . |.  ||. .|. .| ||  | |  ....  . |||| |.. .    ..|||||| ..|.|||          |...  .. .. .|||
peltilvadlflnrdknryldilpad.nrvil.pglpvsg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------ITNVKEEGkvkcqQYWPNSDTKDYGpfsvtlSDE---QLLTDYTVRKMHVKVKDCYEINLSQIILFNQIKNEYkPTKGP
                     .... . |      ... .| ...       .     .|.... .. ... | |  .  |...  | .. .|. ...||
srdevladelsrLdaAlgKtpllildgng.....neptaadlellk......eelydpelferlgikylripvpDgsaplledfdeflefieea.dkggp

MLVHCSAGVGRTGTFMAIDMGLQQAekegGIDIISIINRMRQQRM
 ||||.||.||||||..... . .     |...  .....|..|.
vlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRp
0041856 (Phosphotyrosine protein) phosphatases II 19-215 6.3e-35 115.8 In-house 1-151 (182) alignment 
Range on Protein: 19-215
Range on HMM: 1-151/182.0
NKLLNRFANIVVYDDNRitlrpmsghndcPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITnvkeegkvkCQQYWPnsdtkdy
|. .||. .|. || .|            .  |||| ..  .  . ..||||||  .|. ||........  .||..|         . .|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

gpfsvtlsdeQLLTDYTVRKMHVKVKDCYEINLSQIILFNQIKNEykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekegGIDIISIINRMRQQRM
          .||... .. ... . |    .|.... | .. .|    .|| |||||||||||||. |... ...     |... .... .|..|.
..........ellerlgiqylylpwpDhgvpdldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRp
0051429 (Phosphotyrosine protein) phosphatases II 50-215 1.1e-34 115.7 In-house 5-205 (272) alignment 
Range on Protein: 50-215
Range on HMM: 5-205/272.0
EYINACYIKDYsnqYQ------YIATQGPVSNTLVDFWQLiWQERSPIIVMITNVKEEGKVKCQQYWP------------NSDTKDYGPFSVTLSDEQLL
 |||| ... |   ..      .....||  .|  |||.| ....   ||..... | |..|| .|||               |  || ..|||  |.||
gyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

TDYTVRKMHVKVK-DCYEINLS-----------------QIILFNQIKNeykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID--------IIS
.||..|.. .. . .  |.                     . |.... .     .||.|||||||..||||. |... |.. ..|  .|        .  
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

IINRMRQQRM
.....|.||.
aveelraqrp
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 9-215 1.4e-34 114.3 In-house 23-239 (267) alignment 
Range on Protein: 9-215
Range on HMM: 23-239/267.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHndcpheYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEgkvKCQQ
 |..  ..  |.  ||. . . |||.|. ||           |||| |.. |  . ..|.||.|..||  ||...| ... |.||..|.| ..   . ..
stisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirl

YWPNS--DTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCYE------------INLSQI----ILFN-QIKNEYKPTKGPMLVHCSAGVGRTGTFMAID
.||    ..| |  ..|  | |.   || .  . .|.|.               ||  .      ||    ||. .    |..|.||.||||.|||. ||
fwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvid

MGLQQAEKEGGIDIISIINRMRQQRM
  |..| .||  ||   . ..|.||.
sqleraktegvsdifdflrkirsqri
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 10-144 1.4e-34 114.4 In-house 35-169 (315) alignment 
Range on Protein: 10-144
Range on HMM: 35-169/315.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMsgHNDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQY
  .|. .. |   ||. ||. .| .|. |  .   ..  ..|||| ||| . ..  |||.|||   .. |||....||.   |||.|. .|. |.||.||
rqrvaretinfkknryknilPldsarvklevi..ddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

WPN--SDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVK
||.  .|. ..| ..|.| . .  || ..||. ..  
wPdrkadsvefGsikvellsleadtdgvarklvtrks
subfamily_PTPN23_pd Subfamily PTPN23 17-147 2.6e-34 113.3 In-house 41-168 (288) alignment 
Range on Protein: 17-147
Range on HMM: 41-168/288.0
PSNKLLNRFANIVVYDDNRITLRpmsghnDCPHEYINACYIKDYSNQ-YQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNS--
  .   ||. .|. || ||..||      .   .||||...|| | .  ..||||.|  .|| |||.......|..|||... .| || |...|||..  
klyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkg

DTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCY
.|. .|..||||.... .  .  |.......|  
etvkfgdlsvtlksvretethvervlkletldad
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 8-145 3.6e-34 113.1 In-house 38-172 (315) alignment 
Range on Protein: 8-145
Range on HMM: 38-172/315.0
EHTVTVGLTPSNKLLNRFANIVVYDDNRITLrPMSgHNDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQ
 | . |     ||  ||. ||. ||  |. | |.   ||   .|.|| .|. |. . .|||.|||  ... |||.|...|    |||.||. |. | |..
lhpldvakkienkqknryiniiaydksrvql.pll.endphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkae

QYWPNSdTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKD
.|||.     ||...||. .|.  |.|||| . | ..|
kywpdk.kviyGkitvtrkseevnteytvrtlsvvfgd
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 20-144 7.2e-34 112.1 In-house 29-157 (274) alignment 
Range on Protein: 20-144
Range on HMM: 29-157/274.0
KLLNRFANIVVYDDNRITLRPMSGHNDcPHEYINACYIKDYSNQY-QYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSDT---
.  ||. .|.  .  |..|.. |....   .|||| ||| |...   |.|||||..||. |||..|.||....|||.|..||. . ||..|.|..     
qtknryktilPnensrvllesessede.dssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

-KDYGPFSVTLSDEQLLTDYTVRKMHVKVK
 . || .... ..     ||.|||. .|  
serygdveikvekiverndysvrklvlkyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 12-142 3e-33 110.5 In-house 54-176 (319) alignment 
Range on Protein: 12-142
Range on HMM: 54-176/319.0
TVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITnvkeegKVKCQQYWP
|    . ||  ||. ||. .| |.. |... | .    .|||| ... | .. .|||.|||  ||| |||..||. ..  ||..|      | || ||||
tfanldqnkdknriinilafdknvvklerliGeefs..dyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

NSDTKDYGPFSVTLSDEQLLTDYTVRKMHVK
.   . .. | | ..  .   .|.||.... 
lkivikeerfkvkvdsveetaeyvvrdiels
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 9-145 3.2e-33 110.2 In-house 38-173 (325) alignment 
Range on Protein: 9-145
Range on HMM: 38-173/325.0
HTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMsgHNDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLI--WQerSPIIVMiTNVKEEGKVKC
 . .|   | ||  ||| |.| .| .|. |  .  ..|   .|||| |..|. ..  ..|.| | ..|. |.|.|.  |.  ....|. .|. ..|| .|
iakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..csvvvv.lneldlgkdrc

QQYWPNS--DTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKD
 .|||.   ..| .|.. | |   . ..||  |...||  .
avywpkemgksktfGglevklrtieeisdyvhrvldvkqvk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 12-143 4.4e-33 110.0 In-house 18-141 (284) alignment 
Range on Protein: 12-143
Range on HMM: 18-141/284.0
TVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITnvkeegKVKCQQYWP
|    . ||  ||. .|. .| |.. |... | .    .|||| .|. | .. .|||||||  ||| |||..||. ..  ||..|      | || ||||
tfanldqnkdknrighilafdknvvklerliGeefs..dyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

NSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKV
.   . .. | | ..  .   .|.||....  
lkivikeerfkvkvdsveeseeyvvrdielse
0036282 (Phosphotyrosine protein) phosphatases II 49-215 4.6e-33 109.7 In-house 2-150 (174) alignment 
Range on Protein: 49-215
Range on HMM: 2-150/174.0
HEYINACYIKDYSNQYQYIATQGPVSntlvdFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNsdtkdygpfsvtlsDEQLLTDYTVRKMHVKVKDCYE
. |||| ... .     .||.||| .     ||........ ..|| .. || |..|| .|||               . . |... .. ... . |  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............lredlerlgiqylylpwpDhgv

INLSQIILFNQIKNEYKPT--KGPMLVHCSAGVGRTGTFMAIDMGLQQAEkEGGIDIISIINRMRQQRM
 .||... | .. .|.     .||.|||||||||||||..|... |.. . |. .|..... ..|.||.
pdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrp
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 19-140 6.7e-33 108.8 In-house 8-127 (239) alignment 
Range on Protein: 19-140
Range on HMM: 8-127/239.0
NKLLNRFANIVVYDDNRITLRPMSghNDCPHEYINACYIKDYSNQ-YQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSDTKd
||  ||.|||| || .|. |  .|  ||   .|||| |..||      |||||| |. .  |||...||||  .|||.| . |  | ||.||||.| .| 
nkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGPFSVTLSDEQLLTDYTVRKMH
|  . |||   ....|| .| . 
ycnlrvtlrktevfadyiirtfv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 19-140 7e-33 108.8 In-house 7-126 (239) alignment 
Range on Protein: 19-140
Range on HMM: 7-126/239.0
NKLLNRFANIVVYDDNRITLRPMSghNDCPHEYINACYIKDYSNQ-YQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSDTKd
||  ||.|||| || .|. |  .|  ||   .|||| |..||      |||||| |. .  |||...||||  .|||.| . |  | ||.||||.| .| 
nkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGPFSVTLSDEQLLTDYTVRKMH
|  . |||   ....|| .| . 
ycnlrvtlrktevfadyiirtfv
subfamily_PTPN13_pd Subfamily PTPN13 10-148 1.2e-32 108.3 In-house 28-164 (273) alignment 
Range on Protein: 10-148
Range on HMM: 28-164/273.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGhndcpheYINACYIKDY--SNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQ
|..|| . .||  ||. |.. ||. |..|   .|       |||| .||     ..|.|||.|||. .|  ||||..|. .. .|.|.|. ||.|||||.
tcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

QYWPNSDTKD---YGPFSVTLSDEQLLTDYTVRKMHVKVKDCYE
.|||.|  |    .. . |.| . | | ...||...|| ..  |
rywPesknkklkvsnrlevellkvqkldgfvvralavkdsesge
0049260 (Phosphotyrosine protein) phosphatases II 57-215 1.6e-31 104.4 In-house 2-130 (152) alignment 
Range on Protein: 57-215
Range on HMM: 2-130/152.0
IKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWpnsdtkdygpfsvtlsdeqlltdytvRKMHVKVKDCYEINLSQIIL
|. | .....|||||| .||| |||.....    .|||.|.  | ||.|| ||.                          . .|. . | .  .|||..|
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................qylhlpwpDhgvpdlsqlll

FNQIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRM
|  .  |   .  .|| |||||||||||||..|... |       |...  .....|..|.
flllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRp
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 10-214 1.8e-31 103.9 In-house 36-215 (392) alignment 
Range on Protein: 10-214
Range on HMM: 36-215/392.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMsghNDCP-HEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGkvkcqq
  ||. .. |.  ||. ||. || .|. |  .   .| | ..|.|| ||. . |.  |||.||| . .| |||....||.   |.|.|..||        
pqtvaqkeinlkknryknilpydsarvklevi...ddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywpnsdtkdygpfsvTLSDEQLLTDYTVRKMHvkVKDCYEINLSQIILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
                  | .  . . . .     ||  .   | . . ...| ..     |...||||||||||  ..||  . .|.|   .|.. .. 
...............kgddartvaqfhftewP..dkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvt

RMRQQR
 .|..|
nirrkr
subfamily_PTPN14_pd Subfamily PTPN14 10-142 2.7e-31 103.7 In-house 40-175 (300) alignment 
Range on Protein: 10-142
Range on HMM: 40-175/300.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSgHNdcPHEYINACYIKDY--SNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQ
.....  | |.  ||| ... |.|||. | |   .|   ..||||  ||    .....||..|||. .|. ||||..|..   .|||.|. .|.|| |. 
llstaklpenaeknrfkdvlPyednrvelsptk.en..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

QYWPNS----DTKDYGPFSVTLSDEQLLTDYTVRKMHVK
.|.|..    .| ..| | ||    .  . .. .....|
kyfPkleskkktvefgkfkvttkfsedsdsvittglklk
0046846 (Phosphotyrosine protein) phosphatases II 47-215 1.4e-30 101.7 In-house 10-152 (176) alignment 
Range on Protein: 47-215
Range on HMM: 10-152/176.0
CPHEYINACYIKDYsnqyQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNsdTKDYGPfsvtlsdeqlltdytvRKMHVKVKDC
 .  |||| .|  .     .||||||. .|| ||........  ..|..|. .| |..|| .|||    ...|                 . .|. . | 
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi................qylhlpwpDh

YEINLSQIILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDmglqQAEKEGGIDIISIINRMRQQRM
   .|.... . .. .|.   .|| |||||||.|||||. |..      |.| |...  .. ..|.||.
gvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp
0043147 (Phosphotyrosine protein) phosphatases II 49-215 1.6e-30 101.5 In-house 5-141 (172) alignment 
Range on Protein: 49-215
Range on HMM: 5-141/172.0
HEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVkeegkvkcqqywpnsdtkdygpfsvtLSDEQLLTDYTVRKMHVKVKDCYE
. |||| |.. |    ..|||||| .||| |||......   .||..|.                           | | .||... .. ... . |   
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................lydpellerlgiqylylpwpDhgv

INLSQIILFNQIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRM
 .|.... | .. .|   .  .||.|||||||||||||. |... |       |...  ... .|..|.
pllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRp
subfamily_PTPRN_pd Subfamily PTPRN 8-143 3.1e-30 99.9 In-house 45-180 (297) alignment 
Range on Protein: 8-143
Range on HMM: 45-180/297.0
EHTVTVGLTPSNKLLNRFANIVVYDDNRITLRPMSGHNDcpHEYINACYIKDYS-NQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKC
..| .|. .. |   || .... ||..|..|.  . ...  ..||||  | |    .  |||||||...|. ||||..|.. . .||..|...|||  .|
pstkevakaeknvkknrskavlpydhsrvklkeeasaek..sdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc

QQYWPNSDTKDYGPFSVTLSDEQLL-TDYTVRKMHVKV
..|||.  .. |. . | |  | .   || || ...| 
krywpdeGsevyhiyevhlvsehiwcddylvrsfylkn
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 22-167 1.6e-29 97.6 In-house 41-186 (287) alignment 
Range on Protein: 22-167
Range on HMM: 41-186/287.0
LNRFANIVVYDDNRITLrpmSGHNDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSDT-KDYGP
 ||.|... .||.|. |   | . .   .|||| |.  | .. ..||.|||.. |. |||......||  ....|   ||.. || .|||. .     | 
knryadvlPiddtrvll...saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGG

FSVTLSD-EQLLTDYTVRKMHVKVKDCYE-INLSQIILFNQIKNEYKPT
.||.| | ...  .|.|| . .   .  |   . |. |..  ..   ||
ysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 22-142 3.7e-29 96.8 In-house 54-169 (297) alignment 
Range on Protein: 22-142
Range on HMM: 54-169/297.0
LNRFANIVVYDDNRITLRPMSghNDCPHEYINACYIKdySNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKvKCQQYWPNSDTKDYGPF
 .|..||. || .|..|. .   .|   .|.|| ..|  .|....|.|| |  .|. |||.....|.  .|||... .|. | ||..||... .. .|  
ksRYkniLPydssRvkLaivn..ddpdsDyvnasfvk..gnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdv

SVTLSDEQLLTDYTVRKMHVK
||.|.  .  . .  |...|.
svvllsvsereGfikrelevt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 13-142 4.4e-29 96.3 In-house 14-146 (270) alignment 
Range on Protein: 13-142
Range on HMM: 14-146/270.0
VGLTPSNKLLNRFANIVVYDDNRITLRPMSGhnDCPHEYINACYIKDY-SNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWP
.  .  .| |||.|.|.     |..| ...   |   .|||| |.. . ... .|||..||. .|| .||..||.|... |||.|...|.|. ||..|||
lpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

NSDTK----DYGPFSVTLSDEQLLTDYTVRKMHVK
..  .     .|  .|. . |.  . | .......
aepkekvkledgkikvlalseekeegyiltrlrle
subfamily_PTPN1_pd Subfamily PTPN1 7-143 3.6e-28 93.1 In-house 20-155 (290) alignment 
Range on Protein: 7-143
Range on HMM: 20-155/290.0
SEHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmSGHNdcphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKC
|......  .|.|. |||. ..  ||  ||.|.  ...|    .||||  ..    . .|| ||||..||   |||..|...|  .||. .| |....||
sdfptreaklpenrnlnryrdvspydhsrikle..radn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

QQYWPNSDTK-----DYGPFSVTLSDEQLLTDYTVRKMHVKV
.||||. . .     .   ..|.|  |.    ||||..... 
aqywPqgeeekellledtklkvkliseerksyytvrllelen
subfamily_CG7180_pd Subfamily CG7180 18-143 8.3e-28 91.9 In-house 41-163 (296) alignment 
Range on Protein: 18-143
Range on HMM: 41-163/296.0
SNKLLNRFANIVVYDDNRITLRPMSGHNDCPheYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKvKCQQYWPNSDTKD
 |.  ||  ..| || ||. |. . |...    |||| |.  .  . .|| |..|. .|. .||.|...| .  .|..|.. .  | ....||||   ..
enreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

YGPFSVTLSDEQLLTDYTVRKMHVKV
||.. | .  |. ... . |..... 
ygeifveiveekqyanlkirtfkltk
0044763 (Phosphotyrosine protein) phosphatases II 31-214 5.3e-27 90.0 In-house 2-151 (178) alignment 
Range on Protein: 31-214
Range on HMM: 2-151/178.0
YDDNRITLRPMSGHNDcpHEYINACYIKDYsnqyQYIATQGPvsntlVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSDTkdygpfsvtlsdeql
.|..|  | ...|..    .||||..| ..     |.....|     .|...|....    ||..|. .| |..|| .||| .                 
ldrtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

ltdytVRKMHVKVKDCYEIN-LSQIILFNQIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekegGIDIISIINRMRQQR
     .. .|. . |  . . |...  | .. .|.  . .|| ||||||||||.||..|... ...     |... ..|...|..|
.....iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerR
0051082 (Phosphotyrosine protein) phosphatases II 50-215 1.5e-26 88.2 In-house 4-133 (151) alignment 
Range on Protein: 50-215
Range on HMM: 4-133/151.0
EYINACYIKDYsnqyqYIATQGPVSntlvDFWQLIWQERSPIIVMITNVKEEGkvKCQQYWPNSDtkdygpfsvtlsdeqlltdytVRKMHVKVKDCYEI
 |||. |. ..     .....|| .    ||..|....    ||.... .| |  .| .|.|. .                     .. .|. . |  . 
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.....................ievlhipildwpdp

NL----SQIILFNQIKNEykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekeggIDIISIINRMRQQRM
.|     ... | .. ..  . .||.|||||||.|||||..|... |..      ... .... .|..|.
glplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrp
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 147-216 1.2e-25 85.0 In-house 195-264 (290) alignment 
Range on Protein: 147-216
Range on HMM: 195-264/290.0
YEINLSQIILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMK
 . . . ... ...|...|.......||||..|||...|.|..........||.||........|.|...
tnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 18-117 1.5e-25 84.7 In-house 32-129 (297) alignment 
Range on Protein: 18-117
Range on HMM: 32-129/297.0
SNKLLNRFANIVVYDDNRITLRPMSGHNDcpheYINACYIK--DYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSDT
|    ||. .|. .||.|. |.     .|    |||| |.   |  ....|| .|||.|.|. |||.|....   .|||.....|.|. ||  |||... 
sslrknryrdilatddtrvkllrviterd....yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

KD
. 
er
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 10-117 8.5e-24 78.9 In-house 40-157 (350) alignment 
Range on Protein: 10-117
Range on HMM: 40-157/350.0
TVTVGLTPSNKllNRFANIVVYDDNRITLR----P--MSGHNDCPHEYINACYIKDY------SNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITN
 .. |.    |  ||. ||. |. .|. |.    .     |   . .|||| |.|          ...|||||.|. .|. ||...| .   ..|...|.
ilseGvelfak..nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

VKEEGKVKCQQYWPNSDTKD
  | .  ||..||.. . .|
dvelnlekcyrYWqegsydd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 22-143 3.2e-23 76.9 In-house 51-165 (439) alignment 
Range on Protein: 22-143
Range on HMM: 51-165/439.0
LNRFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKvkcqqYWPNSDTKDYGPF
 ||. ... .|  |.||. . |       |||| ||| | ..  |||||||  .|  |||.|......  |||.||. |  |     ||| ..   ||  
knrykdvgafdhtrvtlqeipgvphs..hyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdi

SVTLSDEQLLTDYTVRKMHVKV
.|    .  | .|..| ..|  
avrvdrnielpnyvirgfkvfn
subfamily_ptpA1_pd Subfamily ptpA1 18-149 5.4e-23 76.4 In-house 46-172 (418) alignment 
Range on Protein: 18-149
Range on HMM: 46-172/418.0
SNKLLNRFANIVVYDDNRITLRPMSGHNDcpHEYINACYIkDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSDTKD
 |   ||..||.  .  |. |. .  ..    .|||| || | .   |.|.||||. ||. |||...|..|  ||||..   |. ..||..|||.    .
hntsknrytnilpvnhtrvqlkkiqdkeg..sdyinanyi.dgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

ygPFSVTLSDEQLLTDYTVRKMHVKVKDCYEI
   ||.    ....  |.|  . |      ||
..qfsiygngnevfgtysvelveviqdperei
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 21-126 1.2e-21 71.7 In-house 54-157 (310) alignment 
Range on Protein: 21-126
Range on HMM: 54-157/310.0
LLNRFANIVVYDDNRITLRPMSGHNdcpHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNS-DTKDYG
  ||....|. |. |. |.         ..|| | |.|    .  .| .|||.  |..|||..|.|||.  |... .| |||. ||  |||    |. ||
hknrysdvvcldtsrvklkidksry...edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

PFSVTLS
   ||  
cirvtnl
subfamily_PTPRD_pd Subfamily PTPRD 155-214 2.9e-21 70.8 In-house 201-260 (564) alignment 
Range on Protein: 155-214
Range on HMM: 201-260/564.0
ILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
 | .....  .|..||..|||||||||||||..||. |.....|. .|| ......|.||
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqR
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 153-216 3e-21 70.9 In-house 200-264 (305) alignment 
Range on Protein: 153-216
Range on HMM: 200-264/305.0
QIILFNQIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMK
 . |........|  || |.||||||||||||.|.|.|. |....||. .|.  .....|..|||
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmk
subfamily_CG42327_pd Subfamily CG42327 19-142 9.3e-21 68.8 In-house 28-154 (319) alignment 
Range on Protein: 19-142
Range on HMM: 28-154/319.0
NKLLNRFANIVVYDDNRITLRPMSghNDCPHEYINACYIKDYSN-QYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSDTKD
 |  .|..|.|   . |..|. ..  .|   ||..| |.. | . . .|||.| .  ..  |||...|. .| .|| .|.. | |  .| .|.| ..| |
skdksrvinvvPlPetrvvlqrig..dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

----YGPFSVTLSDEQLLTDYTVRKMHVK
    || . ||| . .    | .  . .|
ntslyGdilvtlkgrevkdryaistlllk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 22-117 1.4e-20 68.3 In-house 51-140 (305) alignment 
Range on Protein: 22-117
Range on HMM: 51-140/305.0
LNRFANIVVYDDNRITLrpmsgHNDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSDtKD
 ||. ..   |.||. |     ..  ||||| | |.   .|  ..| || |. .|  ||| . .|..   | |. |..| |  ||..|..  | ||
knrykdvgcldnnrvkl.....egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd.kd
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 11-125 4.5e-20 66.5 In-house 29-144 (281) alignment 
Range on Protein: 11-125
Range on HMM: 29-144/281.0
VTVGLTPSNKLLNRFANIVVYDDNRITLRP-MSGHNdcPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQY
.||   | |.  ||..|| . |  |. |.  |  .|    .|| | ||.    .  || ||||  .|  |||..|||| .  |||. .. |  . || .|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnkn..stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPNSDT--KDYGPFSVTL
.|       ..  .||. 
fprnahcclqfdklsvsy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 10-116 6.3e-20 66.4 In-house 32-134 (307) alignment 
Range on Protein: 10-116
Range on HMM: 32-134/307.0
TVTVGLTPSNKLLNRFANIVVYDDNRITLRpMSGhndCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQY
.|||    .|   ||. .. . | .|| .. ..|      .|| | |.    .  ..|..|||  ||  .|| .. ||.   ..|. .| | .|.||.||
gvtveafsantdknryqdvkcqdkgrivvk.fdg...lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqy

WPNSDTK
||  . .
wpleegq
Y_phosphatase Protein-tyrosine phosphatase 155-215 1.1e-19 66.1 Pfam-A 157-217 (235) alignment 
Range on Protein: 155-215
Range on HMM: 157-217/235.0
ILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
 | ...... ....||..|||||||||||||.|.|. |.|.|.|. .|. .|....|.||.
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
Y_phosphatase Protein-tyrosine phosphatase 155-215 1.1e-19 66.1 In-house 157-217 (235) alignment 
Range on Protein: 155-215
Range on HMM: 157-217/235.0
ILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
 | ...... ....||..|||||||||||||.|.|. |.|.|.|. .|. .|....|.||.
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 23-139 1.3e-19 65.0 In-house 60-171 (290) alignment 
Range on Protein: 23-139
Range on HMM: 60-171/290.0
NRFANIVVYDDNRITLRpmsghNDCPHEYINACYIKDYSNqyQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSDTK--DYGP
||. ..|  |  |. |.     .  . .|. | |.|       .| |||.. .| .|.|... ||.   |||. .. |.|| ||.||.|. . .   .| 
nrykdvvcndktrvilk.....dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

FSVTLSDEQLLTDYTVRKM
..|. | |.   . ...|.
itvlcseeddkdaniikkt
PTPc_DSPc_SM00012 151-215 2.5e-19 64.8 In-house 20-87 (105) alignment 
Range on Protein: 151-215
Range on HMM: 20-87/105.0
LSQIILFNQIKNEYKPT--KGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRM
 | . |....|....    ..|..|||||||||||||.|.|. ||| ||| . .||  |....|.||.
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRp
subfamily_PTPRB_pd Subfamily PTPRB 158-215 3.7e-19 63.9 In-house 206-265 (293) alignment 
Range on Protein: 158-215
Range on HMM: 206-265/293.0
NQIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
......   . .|.|..|||||||||||||.|.|. ||. |.|  .||..|. ..|..|.
rtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRn
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 156-214 6e-18 60.0 In-house 203-262 (319) alignment 
Range on Protein: 156-214
Range on HMM: 203-262/319.0
LFNQIKNEY-KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
|...|..   |...||. |||||||||||||...|. |.. ..|| .|. |...|.| ||
llkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqR
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 161-214 7.1e-18 59.7 In-house 206-259 (318) alignment 
Range on Protein: 161-214
Range on HMM: 206-259/318.0
KNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
| . |...||..|||||||||||.|.|.|. |.....|. .|.  .....|.||
kaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqr
subfamily_egg_pd Subfamily egg 24-192 1e-17 58.8 In-house 45-225 (307) alignment 
Range on Protein: 24-192
Range on HMM: 45-225/307.0
RFANIVVYDDNRITLRPMSGHNDCphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEgkVKCQQYWPNSDTKD--Y--G
|   .   |  |..|.   |      ..| | ..|      ..| .| |. ||  |||....||. . |||.|  ||    .|. |||.....   .  |
rskrvhckdssrvklelrrGqyld..dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpG

PFSVTLSDEQLLTD--YTVRKMHVKVKDCYEINL----------SQIILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGL
 . ..  . .  .|  ..| |...   |  |  |          |..    ..    .    |..|..  || ...|..||.. |
slrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieial
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 163-215 1.3e-17 58.6 In-house 191-244 (270) alignment 
Range on Protein: 163-215
Range on HMM: 191-244/270.0
EYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
| .  | .|.|||||||||||||..|.|....  |... .|...||...|..||
ekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRm
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 158-216 2.1e-17 57.8 In-house 216-274 (301) alignment 
Range on Protein: 158-216
Range on HMM: 216-274/301.0
NQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMK
..|. . |. .||..||||..|.|.|.......|| |.  || .|.. .....|.....
dvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 158-214 1.1e-16 55.8 In-house 191-247 (274) alignment 
Range on Protein: 158-214
Range on HMM: 191-247/274.0
NQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
.. ..| .   .|..||||||.|||| |.||.....| ..|. .|...|.  .|..|
eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldr
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 154-215 1.4e-16 55.6 In-house 208-270 (298) alignment 
Range on Protein: 154-215
Range on HMM: 208-270/298.0
IILFNQIKNeYKPTKG--PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
. | ....  ..   |  |..|.|||||||.|||.|||  |....||  .|.  .....|..|.
ldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrp
0048076 (Phosphotyrosine protein) phosphatases II 126-215 1.7e-16 55.7 In-house 38-123 (145) alignment 
Range on Protein: 126-215
Range on HMM: 38-123/145.0
SDEQLLTDYTVRKMHVKVKDCYEINL-SQIILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQqaekeGGIDIISIINRMRQQRM
|...||... .. ... . |. . .| .... | .. .|. . .||.|||||||||||||..|... |.      |... ......|.||.
selellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrp
subfamily_PTPN9_pd Subfamily PTPN9 162-214 2.9e-16 54.4 In-house 217-269 (297) alignment 
Range on Protein: 162-214
Range on HMM: 217-269/297.0
NEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
....|.. |..||||||.||||||...|. |.. |..| .|..  ....|.||
wkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 18-126 3.4e-16 54.1 In-house 34-139 (285) alignment 
Range on Protein: 18-126
Range on HMM: 34-139/285.0
SNKLLNRFANIVVYDDNRITLRpmsGHNdcpHEYINACYIKDY-SNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNS--D
.|  |||.|.. . .. |. |.    |.   ..|| | ...    .|  ||.||||. .|| |||..|.||.   ..|.  . | |  ||  |.|.   .
anpdlnryadvrcieetrvvlk...nhd...rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

TKDYGPFSVTLS
   .| . .||.
vvkfgkyeitlt
0048179 (Phosphotyrosine protein) phosphatases II 130-215 6e-16 53.9 In-house 44-125 (144) alignment 
Range on Protein: 130-215
Range on HMM: 44-125/144.0
LLTDYTVRKMHVKVKDCYEINL-SQIILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekEGGIDIISIINRMRQQRM
 |... .. .|. . |    .| .... | .. .|. . .||.|||||||||||||..|... .     . |... ......|..|.
fleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrp
subfamily_Ptp69D_pd Subfamily Ptp69D 154-214 9.6e-16 52.8 In-house 205-265 (307) alignment 
Range on Protein: 154-214
Range on HMM: 205-265/307.0
IILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
. | .|... ||  ..|..|||||||||.|.|.|.|. ||| ..|  .||. ..  .|.||
lklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqR
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 161-215 1.2e-15 52.4 In-house 201-256 (281) alignment 
Range on Protein: 161-215
Range on HMM: 201-256/281.0
KNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRM
| . | || |...|||||||||||..|.|  ....|.|   .|.  ... .|..|.
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkern
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 161-215 1.5e-15 52.0 In-house 167-222 (250) alignment 
Range on Protein: 161-215
Range on HMM: 167-222/250.0
KNEY-KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
. .  .  ..|..|.|||||||.|.|.|||  |....||  .|.  .|...|..|.
qasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrp
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 52-148 2.3e-15 51.1 In-house 78-176 (301) alignment 
Range on Protein: 52-148
Range on HMM: 78-176/301.0
INACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSD--TKDYGPFSVTLSDEQLLTDYTVRKMHVKVKDCYE
| | .|.   .  ..||||||..||  ||| .. |     |||...  |. . ||..| | .   . | | |.... ...|. .  . | ...|.|  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 22-114 4.1e-15 50.2 In-house 58-146 (305) alignment 
Range on Protein: 22-114
Range on HMM: 58-146/305.0
LNRFANIVVYDDNRITLRPMSghndcPHEYINACYIK-DYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSD
 ||.... . | . . |   |     | .|| | |.      . ..|..|||. .|. .|| .. |..   |||. .  | ||.|| |||| . 
knryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 156-216 4.7e-15 50.3 In-house 200-260 (315) alignment 
Range on Protein: 156-216
Range on HMM: 200-260/315.0
LFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMK
|. ..|   . . |...|||||||||||||...|  |.||| |  ||.  .|...||.|.|
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrik
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 156-215 4.8e-15 50.5 In-house 204-264 (297) alignment 
Range on Protein: 156-215
Range on HMM: 204-264/297.0
LFNQIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
| ........ ..  |.||||.||||||| ...||  . .|..|  .||  .....||.|.
lisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerp
subfamily_PTPRA_pd Subfamily PTPRA 155-215 5.9e-15 50.0 In-house 215-275 (330) alignment 
Range on Protein: 155-215
Range on HMM: 215-275/330.0
ILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
 |....|.  . . ||. |||||||||||||...|  |.. . |. .|.  ...|.|.|| 
kllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrp
subfamily_PTPN6_pd Subfamily PTPN6 161-214 1.4e-14 48.8 In-house 219-276 (306) alignment 
Range on Protein: 161-214
Range on HMM: 219-276/306.0
KNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---GIDIISIINRMRQQR
..| .  ..||..||||||.||||||. ||. |.. ||.|    ||| .... .|.||
qeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 23-114 2.7e-14 47.2 In-house 52-157 (349) alignment 
Range on Protein: 23-114
Range on HMM: 52-157/349.0
NRFANIVVYDDNRITLRP----MSG--------HNDCPHEYINACYIK--DYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQ
||. .|. |.  |. |.       .        .   ...|||| |.|   .| . .||||| |.  |. ||...|  .. .... ... ||..  ||..
nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdi

YWPNSD
|| . .
ywqels
subfamily_PTPRK_pd Subfamily PTPRK 155-215 3.2e-14 47.5 In-house 197-257 (314) alignment 
Range on Protein: 155-215
Range on HMM: 197-257/314.0
ILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
 |  ..|.  ....|...|||||| ||||||.|||. |. .|.|| .|.  ..  .|....
klvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkv
subfamily_PTPN13_pd Subfamily PTPN13 162-214 3.7e-14 47.6 In-house 196-248 (273) alignment 
Range on Protein: 162-214
Range on HMM: 196-248/273.0
NEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
.. .  .||..||||||.||.||...||. |.  |..  .|.  |....|.||
rrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqr
subfamily_PTPN3_pd Subfamily PTPN3 156-215 5e-14 46.9 In-house 196-255 (280) alignment 
Range on Protein: 156-215
Range on HMM: 196-255/280.0
LFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
. .....  . .. |..||||||.|||| ...... |.  |..  . .. |. .||.||.
fvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqra
subfamily_PTPN12_pd Subfamily PTPN12 156-215 7.1e-14 46.4 In-house 195-257 (290) alignment 
Range on Protein: 156-215
Range on HMM: 195-257/290.0
LFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGL---QQAEKEGGIDIISIINRMRQQRM
| .....  .  . |..|||||||||||| .|||.     ..   .  .|. ... ..|.|| 
lielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqra
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 48-214 1e-13 46.1 In-house 45-238 (290) alignment 
Range on Protein: 48-214
Range on HMM: 45-238/290.0
PHEYINACYIKdYSNQYQYIATQGPVSN-------TLVDFWQLIWQERSPIIVMITNVKEEGKV----KCQQYWPNSDT--KDYGPFSVTLSDEQLLTDY
  .|| | ... ..|  . |.|| |  .       |. .|| .. ||..  .||. ...|. .      |..| |.|      .. ..|   .     | 
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

TVRKMHVKVKDCYEINLS--------------QIILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE-KEGGIDIISIINRMRQQR
 .|.. ||  |  |  .               . ... .. .  |  | |..|||  |. |  .. ||..| |    ..| . . .... .|.||
etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 152-215 1.4e-13 45.4 In-house 194-257 (315) alignment 
Range on Protein: 152-215
Range on HMM: 194-257/315.0
SQIILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
| . |  ..| . .. . ..|||||||||||| ...||  ..|....  .|.  ... .|..|.
sllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrp
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 166-215 1.4e-13 45.9 In-house 222-271 (319) alignment 
Range on Protein: 166-215
Range on HMM: 222-271/319.0
PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
  . ...|||||||||||.....|. |.. ..|  .|.  ... .|||| 
nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrn
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 165-215 1.5e-13 45.0 In-house 209-259 (439) alignment 
Range on Protein: 165-215
Range on HMM: 209-259/439.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
|   ||..|||||||||||| .|.|. |.|   |  .||  |.. .|.|| 
keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrk
subfamily_CG7180_pd Subfamily CG7180 161-215 1.6e-13 45.0 In-house 216-270 (296) alignment 
Range on Protein: 161-215
Range on HMM: 216-270/296.0
KNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
|.. .|..||..|..| |..|.| ..|||. |...|||. .|.   . ..|..| 
kvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRp
subfamily_PTPN14_pd Subfamily PTPN14 159-215 1.7e-13 45.2 In-house 221-276 (300) alignment 
Range on Protein: 159-215
Range on HMM: 221-276/300.0
QIKNEyKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
. ..  | .| |.||||||||||||  .  |. ..  |..  ||| ....|.|.|||
seves.keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrm
subfamily_PTPRG_pd Subfamily PTPRG 161-214 1.9e-13 44.5 In-house 213-266 (563) alignment 
Range on Protein: 161-214
Range on HMM: 213-266/563.0
KNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
.   | . ||..||||||||||||....|  |.| ..|  ...  .. ..| ||
saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqR
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 166-215 2.7e-13 45.1 In-house 186-235 (284) alignment 
Range on Protein: 166-215
Range on HMM: 186-235/284.0
PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
  . ...|||||||||||.....|. |.. ..|  .|.  ... .|||| 
nhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrn
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 62-139 2.9e-13 44.5 In-house 3-82 (199) alignment 
Range on Protein: 62-139
Range on HMM: 3-82/199.0
NQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPN--SDTKDYGPFSVTLSDEQLLTDYTVRKM
 | .||||| |. .|. ||||..|.  |  |||. . . . ..    |||   | |  || .|||        |||.  .
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 167-214 3.4e-13 44.4 In-house 220-267 (325) alignment 
Range on Protein: 167-214
Range on HMM: 220-267/325.0
TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
. .|.||||||||||||.|...   |..  .|  .||   ....|..|
astpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdr
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 63-139 3.8e-13 44.0 In-house 3-81 (198) alignment 
Range on Protein: 63-139
Range on HMM: 3-81/198.0
QYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPN--SDTKDYGPFSVTLSDEQLLTDYTVRKM
| .||||| |. .|| ||||..|.  |  |||. . . . ..    |||   | |  || .|||        |||.  .
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 20-135 5.4e-13 43.3 In-house 44-147 (312) alignment 
Range on Protein: 20-135
Range on HMM: 44-147/312.0
KLLNRFANIVVYDDNRITLrpmSGHNDCpheYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWpnSDTKDYg
| |||. || ..|  |.||   .| ..    || | ..|  ..  ....||||. || . ||||     |  |.... . |.|  || .|   ||   . 
kdlnrypniqcwdrgrftl...agdenf...yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi..sdivgf.

pfsVTLSDEQLLTDYT
   | | | .. |.| 
...vdledhrvyteyc
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 15-128 8.9e-13 42.4 In-house 92-198 (244) alignment 
Range on Protein: 15-128
Range on HMM: 92-198/244.0
LTPSNKLLNRFANIVVYDDNRITLRPMSGHNdcphEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEgkvkcQQYWPNSD
. |.|   || .  . .| ||. |   |  |     |||| ..       .|| || |...| .|||... .    ..|..  |.||     ..|||.|.
fnpnnswknregaglpfdfnrvplskgsmgn....tyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse

TKDYG--PFSVTLSDE
  ..     .|||.| 
plewyeeditvtltdr
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 139-215 1.3e-12 41.9 In-house 188-263 (290) alignment 
Range on Protein: 139-215
Range on HMM: 188-263/290.0
MHVKVKDCYEINLSQIILFNQIKNeYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
...|      . ||.. |.  ..   . . ||. ||||||.||||||.||..|||   .   .|.. ..  .|. |.
lkikswpdksvalstlallrtlri.lrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrl
subfamily_eak_pd Subfamily eak 25-128 1.8e-12 41.3 In-house 57-159 (332) alignment 
Range on Protein: 25-128
Range on HMM: 57-159/332.0
FANIVVYDDNRITLRPMSgHNdcPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSD--TKDYGPFS
  .|| || . . | .    |  .  ||||  ..      .|| |  .  . .  |||.. ...|| ||.. .  |..  | ..|.|.      ..| . 
vvkivpydrylvrltssq.ln..rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VTLSDE
|.  . 
verkef
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 156-214 3.9e-12 40.8 In-house 162-220 (239) alignment 
Range on Protein: 156-214
Range on HMM: 162-220/239.0
LFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
|  .| ..  |   | ..||||||||||.|. ||  |.||.|.  .||.  .. .|..|
lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedr
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 156-214 4e-12 40.8 In-house 161-219 (239) alignment 
Range on Protein: 156-214
Range on HMM: 161-219/239.0
LFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
|  .| ..  |   | ..||||||||||.|. ||  |.||.|.  .||.  .. .|..|
lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 162-214 4.2e-12 40.1 In-house 121-173 (440) alignment 
Range on Protein: 162-214
Range on HMM: 121-173/440.0
NEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
.. |  .||.|||||||.||||  .|.|  |..|..   |||.|.|| ||..|
sqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnr
subfamily_CG42327_pd Subfamily CG42327 165-215 4.7e-12 40.2 In-house 244-295 (319) alignment 
Range on Protein: 165-215
Range on HMM: 244-295/319.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRM
.  .||. |||| ||||||. .| |. ... |.    .||  ..  .|..| 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdra
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 59-145 7.3e-12 39.3 In-house 231-315 (440) alignment 
Range on Protein: 59-145
Range on HMM: 231-315/440.0
DYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEgkvKCQQYWP-NSDTKDYGPFSVTLSDEQLLTDYTVRKMHVKVKD
 ||..  .|||| |.  |..|||.|. . |   |.|. ....     |  ||| |. .  .|||.|     . .    || . .| |.
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyke
subfamily_PTPN1_pd Subfamily PTPN1 165-215 8.5e-12 39.4 In-house 198-251 (290) alignment 
Range on Protein: 165-215
Range on HMM: 198-251/290.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQRM
.. .|| ..|||||.||.|||. .|  | . ||..    .||   .  .|..|.
ssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 168-214 8.9e-12 39.1 In-house 221-267 (302) alignment 
Range on Protein: 168-214
Range on HMM: 221-267/302.0
KGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
|  .|||||||||||||..||  |.|   |.   |..||.  .|| |
kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcr
subfamily_PTPN23_pd Subfamily PTPN23 161-214 1.1e-11 39.0 In-house 205-259 (288) alignment 
Range on Protein: 161-214
Range on HMM: 205-259/288.0
KNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINRMRQQR
... ...| |..|||||||||||.|  .   ... ||. |. ||| ...|.|.||
eavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqR
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 19-113 1.2e-11 39.2 In-house 43-131 (288) alignment 
Range on Protein: 19-113
Range on HMM: 43-131/288.0
NKLLNRFANIVVYDDNRITLRpmsghnDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNS
|   .|. |.   |  |. |       | |. ||.|  .    .. . | .| |.  |.  .|... ..    |||.... | || | ..|.|  
nptrdryenlprcditrvkls......ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 164-214 3.2e-10 34.6 In-house 168-218 (237) alignment 
Range on Protein: 164-214
Range on HMM: 168-218/237.0
YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
. .  || ..|||||||||| |. ||  |.||...  .||   .  . ..|
hvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedr
subfamily_PTPRN_pd Subfamily PTPRN 160-215 3.6e-10 34.0 In-house 216-272 (297) alignment 
Range on Protein: 160-215
Range on HMM: 216-272/297.0
IKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRM
.   |.    |..||||.|.||||....||. |..  |    |||.. .. .|.|| 
vnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrp
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 23-99 4.3e-10 33.6 In-house 41-120 (347) alignment 
Range on Protein: 23-99
Range on HMM: 41-120/347.0
NRFANIVVYDDNRITLRPMS---GHNDCPHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVK
||  .  . |. |. | |     .. | .. |||| .||    . .|| || |. .|. |||...   .   .| | . .
nrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 168-215 4.5e-10 33.8 In-house 210-257 (287) alignment 
Range on Protein: 168-215
Range on HMM: 210-257/287.0
KGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
 ||..||...|.||.|...|. . ... |. | .|.  .. |.|..| 
vGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyra
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 154-215 7.5e-10 33.2 In-house 190-250 (285) alignment 
Range on Protein: 154-215
Range on HMM: 190-250/285.0
IILFNQIKnEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
| |.. .| . .| . |. |||||||||| ||. ||    .  ..  |... |.  ||  |.
ielykwvk.kvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 162-195 1.7e-09 31.9 In-house 255-289 (350) alignment 
Range on Protein: 162-195
Range on HMM: 255-289/350.0
NEYKPT-KGPMLVHCSAGVGRTGTFMAIDMGLQQA
. ..     |.|||||||||||||....|. |.. 
shldnarsspilvhCsaGvGrtGtlvtlDsllsdf
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 48-127 2.1e-09 31.8 In-house 12-88 (130) alignment 
Range on Protein: 48-127
Range on HMM: 12-88/130.0
PHEYINACYIKDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEgkvkcQQYWPNSDTKDYGPFSVTLS--D
 ..|||| ..    .  .|. || |...| .|||... .    ..|..  |.||     ..|||.|.  ..    ....  |
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltd
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 8-71 3.4e-09 30.8 In-house 37-95 (95) alignment 
Range on Protein: 8-71
Range on HMM: 37-95/95.0
EHTVTVGLTPSNKLLNRFANIVVYDDNRITLRpmsGHNDcpHEYINACYIKDYSNQYQYIATQG
  . ||| . .|   ||| ||. ||  |..|     . |   .|||||..  |. .  |||.||
gapytvgsseanipknrflnifpydatrvvlt...tkrd..sdyinacfvdgyarkncyiaaqg
subfamily_hpo-7_pd Subfamily hpo-7 75-215 5.9e-09 30.2 In-house 45-207 (263) alignment 
Range on Protein: 75-215
Range on HMM: 45-207/263.0
NTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSD-TKD-YGPFSV---------TLSDEQLLTDYTVRKMHVKVK-DCYE--INLSQIILFNQI
.|.  |.| | | ..  .||... .|||..||..|.|     |  .   .|          |  ..||     .|   .||   |   |.  .  |...|
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

KNEYKPTKG--PMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRM
 |  | ...  .. ||||.|.||.  |  ...  |      .  . ...| .|... .|..| 
lnilkvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 171-214 6.3e-09 30.1 In-house 1-44 (69) alignment 
Range on Protein: 171-214
Range on HMM: 1-44/69.0
MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
|.||||.| ||||||.|| . . .   |  .||   .. ||. |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 152-216 8.9e-09 29.8 In-house 192-252 (288) alignment 
Range on Protein: 152-216
Range on HMM: 192-252/288.0
SQIILFNQIkneyKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMK
| . | . .    | .. |..||.|||||||||.. | . |...  .  . | |.....|..|.|
splrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 147-214 1e-08 29.6 In-house 192-256 (307) alignment 
Range on Protein: 147-214
Range on HMM: 192-256/307.0
YEINLSQIILFNQIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQA-EKEGGIDIISIINRMRQQR
 .|||. | |.. .. .    . |..|||||||||.|| .|| .  ..  . .   |.  ... .|.||
pqinltainlleavryd....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqr
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 162-214 1.6e-08 28.6 In-house 213-266 (305) alignment 
Range on Protein: 162-214
Range on HMM: 213-266/305.0
NEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDI-ISIINRMRQQR
.. .|.|||. ||||||.||||. . ..  |.|      |.    |....|.||
ekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqr
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 164-214 1.8e-08 28.8 In-house 129-182 (198) alignment 
Range on Protein: 164-214
Range on HMM: 129-182/198.0
YKPT-KGPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQR
|.     |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |
yeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqar
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 167-214 2e-08 28.6 In-house 134-183 (199) alignment 
Range on Protein: 167-214
Range on HMM: 134-183/199.0
TKGPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQR
   |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |
kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqar
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 19-105 2.3e-08 27.9 In-house 34-117 (332) alignment 
Range on Protein: 19-105
Range on HMM: 34-117/332.0
NKLLNRFANIVVYDDNRITLRPMSGHNDcpheYINACYIKDYSNQYQYIATQGPVSN-TLVDFWQLIWQERSPIIVMITNVKEEGKVK
|  .||   . ..| .|. | |  |..|    . || ..  ||..  || .| |. . |   ||... . .  .|... .. |. | |
nmdmnriphlycfdhsrvelapqdgkdd....fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 19-111 2.3e-08 28.0 In-house 47-130 (303) alignment 
Range on Protein: 19-111
Range on HMM: 47-130/303.0
NKLLNRFANIVVYDDNRITLRPMSghndcpheYINACYIkDYSNQYQYIATQGPVSNTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWP
|   |||..... |  .. |   |        || | |. .   . . | || |.| |  ||||.| ...   ....    |  |.  .  .|
nmdknrfvdvicldhskvklsdss........yihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 163-215 2.3e-08 28.3 In-house 223-275 (297) alignment 
Range on Protein: 163-215
Range on HMM: 223-275/297.0
EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
  .| . ..||||||||||.|  .  |. |..  |.   |. .|.. .|.|| 
aemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqra
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 173-214 2.3e-08 28.3 In-house 2-43 (69) alignment 
Range on Protein: 173-214
Range on HMM: 2-43/69.0
VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
||||.| ||||||.|| . . .   |  .||   .. ||. |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 161-193 4.8e-08 26.7 In-house 257-290 (349) alignment 
Range on Protein: 161-193
Range on HMM: 257-290/349.0
KNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQ
.. ..     ..||||||| ||||... .|. |.
rlyldtdqlstllvhcsaGcGrtGvlvtldllls
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 165-214 6.5e-08 26.6 In-house 218-268 (305) alignment 
Range on Protein: 165-214
Range on HMM: 218-268/305.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQ-AEKEGGIDIISIINRMRQQR
. .| |..||||||.||||| .||.  |.. ||.     .  ... .|.||
rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqr
0038934 (Phosphotyrosine protein) phosphatases II 48-188 7.3e-08 27.8 In-house 3-135 (194) alignment 
Range on Protein: 48-188
Range on HMM: 3-135/194.0
PHEYINACYIKDYSNQyQYIATQGPVSNTLVDFWQLIWQERspiIVMITNVKEEGKVKCQQYWPNS-DTKDYgpfsvtlsDEQLLTDYTVRKMHVKVKDC
|... .   . |. .  . ||. .|.|..| .... ...     . .. .. .. .||.   .  . ... |        | .....  .. ..  ..| 
Pdrwlkyervgdiitg.rfiafkvPlsgsldkyieelyrfs...pedlvrylkllnvklglvidltnteryY........dpeefekagieylklpfpdd

YE-INLSQIILFNQIKNEYKP--TKGPMLVHCSAGVGRTGTFMAI
..  .|...  | .. .|.    ..|  .||| ||.|||||. | 
gtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 160-209 1.1e-07 25.9 In-house 192-242 (281) alignment 
Range on Protein: 160-209
Range on HMM: 192-242/281.0
IKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINR
|  . .    | ..||||||||.||.||... ||       . ||  |. .
ilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivsh
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 68-114 1.5e-07 25.8 In-house 39-78 (255) alignment 
Range on Protein: 68-114
Range on HMM: 39-78/255.0
AtqgpvsnTLVDFWQLIWQERSPIIVMITNVKEEGKVKCQQYWPNSD
        |.  |.| | | ..  .||... .|||..||..|.|   
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplek
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 163-215 1.8e-07 25.2 In-house 209-261 (301) alignment 
Range on Protein: 163-215
Range on HMM: 209-261/301.0
EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
  | .. |..||||||.||. .|.. ..  .. | .  |..   ....|..| 
lvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrw
PTPlike_phytase Inositol hexakisphosphate 97-188 2.8e-07 25.3 Pfam-A 80-144 (149) alignment 
Range on Protein: 97-188
Range on HMM: 80-144/149.0
NvkeegkvkcqqywpnsdtkdygpfsvTLSDEQLLTDYTVRKMHVKVKDCYEINLSQIILFNQIKNEYkPTKGPMLVHCSAGVGRTGTFMAI
.                          ....|.| . . |. . . ..| .  . ...  | .. ... |..  ....|.|| ||| |.|.|
e..........................evyeeelaegfgvkYvRipitdeqapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamvi
PTPlike_phytase Inositol hexakisphosphate 97-188 2.8e-07 25.3 In-house 80-144 (149) alignment 
Range on Protein: 97-188
Range on HMM: 80-144/149.0
NvkeegkvkcqqywpnsdtkdygpfsvTLSDEQLLTDYTVRKMHVKVKDCYEINLSQIILFNQIKNEYkPTKGPMLVHCSAGVGRTGTFMAI
.                          ....|.| . . |. . . ..| .  . ...  | .. ... |..  ....|.|| ||| |.|.|
e..........................evyeeelaegfgvkYvRipitdeqapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamvi
subfamily_DSP23_pd Subfamily DSP23 138-191 6.5e-07 24.1 In-house 54-107 (148) alignment 
Range on Protein: 138-191
Range on HMM: 54-107/148.0
KMHVKVKDCYEINLSQIILFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMG
 ......| .   | |.  | .. .| .  .  . |||  | |||||..|  . 
lvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylv
PTEN_1 135-185 8.4e-07 24.0 In-house 94-147 (196) alignment 
Range on Protein: 135-185
Range on HMM: 94-147/196.0
TVRKMHVKVKDCYEINLSQII-LFNQIKNEYK--PTKGPMLVHCSAGVGRTGTF
 |.  |. ..|.   .||...   ..... ..  | ..  |||| ||.||.|| 
gveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 19-119 9.2e-07 22.6 In-house 51-149 (302) alignment 
Range on Protein: 19-119
Range on HMM: 51-149/302.0
NKLLNRFANIVVYDDNRITLrpmsghNDCPHEYINACYIKDYSNQYQYIATQGPVSNTL---VDFWQLIWQERSPIIVMITNVKEEGKvKCQQYWPN--S
|   |.  .. ..|.|.. |      . .| .|.||  ..  . ... | .| |....     .||....||.   .|..   .|  |   ....|.   
nlkknqsedvpildsnlvkl......eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

DTKDYG
| |.||
dykeyg
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 168-215 1.4e-06 22.1 In-house 223-270 (310) alignment 
Range on Protein: 168-215
Range on HMM: 223-270/310.0
KGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRM
.|| .||||||..|... .|... ......   .|.  ..  ....|.
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksra
PTPc_motif_SM00404 134-187 1.8e-06 22.9 In-house 45-99 (140) alignment 
Range on Protein: 134-187
Range on HMM: 45-99/140.0
YTVRKMHVKVKDCYEINLSQII-LFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMA
  .. ......|  . .||. .   ... .. . ..|  |||| ||| |..|...
sgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatlii
DSPc Dual specificity phosphatase, catalytic domain 133-187 6e-06 21.2 Pfam-A 37-92 (133) alignment 
Range on Protein: 133-187
Range on HMM: 37-92/133.0
DYTVRKMHVKVKDCYEINLSQII--LFNQIKnEYKPTKGPMLVHCSAGVGRTGTFMA
.   ......|.|  | ..|. .  . . |. . .  ..  |||| ||. |..|...
kseieylripvedetetkiskeleeavefie.kaeqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 133-187 6e-06 21.2 In-house 37-92 (133) alignment 
Range on Protein: 133-187
Range on HMM: 37-92/133.0
DYTVRKMHVKVKDCYEINLSQII--LFNQIKnEYKPTKGPMLVHCSAGVGRTGTFMA
.   ......|.|  | ..|. .  . . |. . .  ..  |||| ||. |..|...
kseieylripvedetetkiskeleeavefie.kaeqkgkkvlVHCqaGisRSatlii
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 165-190 7.5e-06 19.9 In-house 206-231 (312) alignment 
Range on Protein: 165-190
Range on HMM: 206-231/312.0
KPTKGPMLVHCSAGVGRTGTFMAIDM
|  | |.. |||||||||||.. |. 
kkdkkpviahcsagvgrtgtlalies
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 5-58 7.9e-06 19.4 In-house 34-84 (440) alignment 
Range on Protein: 5-58
Range on HMM: 34-84/440.0
GESEHTVTVGLtPSNKLLNRFANIVVYDDNRITLRPMSGHNDcpHEYINACYIK
| |. .   .| |.||. ||. ||..|| .|. |  . |  |   .|||| ||.
glsqpsdiasl.pnnkvknryrnilaydhsrvmleevkgvpd..sdyinasyin
Y_phosphatase3 Tyrosine phosphatase family 156-192 9.8e-06 20.7 Pfam-A 112-148 (164) alignment 
Range on Protein: 156-192
Range on HMM: 112-148/164.0
LFNQIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGL
 .... .    ..||.|.||.||  ||| ..|. . |
ayrkvlealaeeegpvlfHCtaGKDRTGvvaalllsl