Gene PTPRD-15 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP068_AA protein Get Run
AqueP068_AA_0-226 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-230 7.3e-113 371.2 In-house 59-288 (290) alignment 
Range on Protein: 1-230
Range on HMM: 59-288/290.0
DDNRITLRPMSGHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|||||||||.||||||||||||||.||.|....||||||||||.||||||.|||||. .||||.||.||||||||||||||||||.||.||..|..|..|
ddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetl

TDYTVRKMHVKLVDSNdQPPLMITQYHFTSWPDHG-VPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
..|. ||..||  .|. ... ..|||..|.|...| |....|..|......|...|.......||||..|||...|.|..........||.||.......
neyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlks

MRQQRMKMVQTADQYIFVNDAVLESVTCGNT
.|.|....|||..|| .... ||..... .|
qRiqkpgsvqtvqqyqgifqivltyldsfet
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-234 1.4e-101 334.2 In-house 60-287 (287) alignment 
Range on Protein: 1-234
Range on HMM: 60-287/287.0
DDNRITLRpmsghkDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|..|. |.      .. ..||||.||. |......|....|...|...||.||.......|||...  |. . .| ||||....  .|.....| .|.| 
dnyrvllk......gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevn

TDYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHG-VPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
..|..||..||  ...........||..|.|...| |.|..|..|......|...|.......||||..|||...|.|..........||.||.......
agyierklevkn.knkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlks

MRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDS
.|.|....|||..||.|.||.|||......|..|.
qriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_PTPRD_pd Subfamily PTPRD 1-243 8.1e-100 330.1 In-house 61-299 (564) alignment 
Range on Protein: 1-243
Range on HMM: 61-299/564.0
DDNRITLRPMSGHKDCtnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
| .|. |... |....  .|||| ||. |  . .|||||||...|. ||||..|...  .|||.|.. |.|||||..|||...|. || . |||..|. |
dhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeel

TDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
.||..|.. .|  .|...   ...|.||||||||||||.|||.|.. |....  .|..||..|||||||||||||..||. |.....|. .|| ......
adyeirtfklkkkksses..reVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkal

RQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNR
|.||  |||| .||||. .|.|| ..||||.|.|.| .  ...
rkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-245 3.6e-96 316.9 In-house 59-303 (305) alignment 
Range on Protein: 1-245
Range on HMM: 59-303/305.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTK--DYGPFSVTLNDEQ
||.|| |.. . ..   ..||||.... |. . .||..|||. .|..||||||..|..  |||.|...|.|| ||.||||.| |.  ..|.|||.|..|.
dddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksek

VLTDYTVRKMHVKLVDSnDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
  .||. ||...   |. |.    ..||..|.|||||||..|||.|.. .|.....|  || |.||||||||||||.|.|.|. |....||. .|.  ..
tasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevl

NRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMS
...|..||||||| ||| |. ||. | .|||.|..   | |.  |.. 
kqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk
0051299 (Phosphotyrosine protein) phosphatases II 1-224 3.9e-83 274.5 In-house 62-285 (288) alignment 
Range on Protein: 1-224
Range on HMM: 62-285/288.0
DDNRITLRPMSGhkDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|..|. |....|  . .. |||| .|. |  . ..|||||| ..|. ||||..|... ..|||.|...| |..|| ||||..... ||...||| .|.||
dhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevl

TDYTVRKMHVKLV--DSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
 |||||...|. .   . |. ....|..|.|.|||||||......|.| |.... .....||..||||||||||||| |.|. |.| |||||.|. ....
ddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavk

RMRQQRMKMVQTADQYIFVNDAVLES
|.|.||. |||| .||.|| .|.|| 
rlreqRpgmvqtpeqyrfvyealley
0050432 (Phosphotyrosine protein) phosphatases II 1-229 4.4e-83 274.5 In-house 81-303 (308) alignment 
Range on Protein: 1-229
Range on HMM: 81-303/308.0
DDNRITLrpmsghkDCTNEYINACFIKDY--SDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS---DTKDYGPFSVTLN
| .|. |       | .. |||| ... |    . ..|||||| ..|. ||||..|... ..|||.|. .| |..|| ||||..   ... ||.|.||| 
dhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtll

DEQVLTDYTVRKMHVKLVDSNdqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYkpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIS
.|.|| |||||..... ....  . ...|..|.|.|||||||......|.| ..... .   .||..||||||||||||| |.|. |.| |||||.|. .
seevlddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfe

IINRMRQQRMKMVQTADQYIFVNDAVLESVTCGN
.....|.||. |||| .||.|. .|.|| . .  
avkklReqRpgmvqtpeqylflyralleylklkl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-242 1.2e-82 272.5 In-house 59-297 (318) alignment 
Range on Protein: 1-242
Range on HMM: 59-297/318.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|. |. |....|..  . .|||| .|  |  . .|||.|.|.. |. ||||..|.    .|||.|.. |.||.|...|||..... ||   |.|..|  |
dhtrvkLqmlegee..gsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevel

TDYTVRKMHVKLVDSNDqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
.||..|...|.  ....    .. |||.|||||.|||| ..|.|.. |....   |...||..|||||||||||.|.|.|. |.....|. .|.  ....
sdyvlrefkvtrteeee..srqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkq

MRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFN
.|.||  |||| |||.|. |..|| ...|.|.||... |   .
lreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrir
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2-241 2e-82 271.8 In-house 62-299 (319) alignment 
Range on Protein: 2-241
Range on HMM: 62-299/319.0
DNRITLRPMSGHKDCtnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLT
  |..| .. | ..   .|||| ||  | .. ..||||.|.. |. ||||..|.|.  |.||.|.. |..|||...|||. . ..|| . |||..|. | 
rtrvvlseldgvegs..dyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeele

DYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
|| .||....   |..    .......|.||||.|||.|||.|.. .||..  . ...||. |||||||||||||...|. |.. ..|| .|. |...|.
dyiirklklnk.kssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrl

RQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVF
| ||  |||. .||.|. .|.|| |..|.|... .. |  .
RtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl
0040438 (Phosphotyrosine protein) phosphatases II 1-236 2.3e-82 272.1 In-house 56-287 (317) alignment 
Range on Protein: 1-236
Range on HMM: 56-287/317.0
DDNRITLRPMSGHKDctNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|..|. | |..|. |  . |||| ... ..   ..|||||| ..|. ||||..|...  .|||.|.  | |..||.||||. .|. ||.|.||| .|..|
dhsRVkLsplggdld..sdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeel

TDYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
 ..|.|...|.    .|......|..|.|.|||||||.. ...|.| ..... ... .||.|||||||||||||| |... |.| |||||.|. ......
agitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkel

RQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRN
|.||...||| .||.|. ||.|| .....| ..  .
reqRpgavqtpeqyrflydalleylkrkltlepase
subfamily_PTPRB_pd Subfamily PTPRB 1-226 2.6e-81 267.9 In-house 64-286 (293) alignment 
Range on Protein: 1-226
Range on HMM: 64-286/293.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS-DTKDYGPFSVTLNDEQV
| .|. | ......  ...|||| .|..|. . ..||||||. .|. ||||..|...  ||||.|...|.|||||..|||.  ..  ||  .|||. |..
dhsrvkLaalkdes..gsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeee

LTDYTVRKMHVKLvdsnDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
|.|...|.....     ..    ..|||||||||||||| ....|.| |.....   . .|.|..|||||||||||||.|.|. ||. |.|  .||..|.
ledwvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgiv

NRMRQQRMKMVQTADQYIFVNDAVLESVT
 ..|..|. .||| .||||....||. ..
aelReeRnllvqtekqYifihqcvldllr
0046845 (Phosphotyrosine protein) phosphatases II 1-231 2e-80 265.5 In-house 41-280 (284) alignment 
Range on Protein: 1-231
Range on HMM: 41-280/284.0
DDNRITLRPMSGHkDCTNEYINACFIKDY-----SDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD-TKDYGPFSVTL
|..|. |....|. . ...|||| ... |       . ..||||||...|. ||||..|... ..|||.|. .| |..|| ||||... .. ||.|.|||
dhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtl

NDEQVLTDYTVRKMHVKLVDSnDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---
 .|.|  |||||.. .. ..  .......|..|.|||||||||......|.| | ... ..  |..||..||||||||||||| |.|. |.| ||||   
lseevkddytvrtleltnlgy.tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglll

GIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQ
|.|. ....|.|.||. |||| .||.|| .|.|| . ...| 
gvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0036941 (Phosphotyrosine protein) phosphatases II 1-231 7.3e-80 263.7 In-house 52-283 (297) alignment 
Range on Protein: 1-231
Range on HMM: 52-283/297.0
DDNRITLrpmsghKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDEQ
|..|. |      .|  . ||||.... |. ....|||||| ..|. ||||..|... ..|||.|...| |..||.||||.   ... ||.|.||| ...
dhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsve

V--LTDYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE---KEGGI
|  |.|||.|...|. .  ........|..|.|.||||||||...|.|.| ..... .|  | .||.||||||||||.||| |.|. ||| |   ||||.
vvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggv

DIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQ
|| .... .|.||. .||| .||.|. .|.|| . ...| 
dileavkklReqRpgavqtleqyrflyeallellkkkltk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-232 4e-78 257.7 In-house 70-297 (298) alignment 
Range on Protein: 2-232
Range on HMM: 70-297/298.0
DNRITLRPMSGHKDCtnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLT
  |. |. ... ...  .|||| |.. |...  .||||.|. .|..||||....|    |||.||. | .|.|...||||. .. || ..|.|  ... .
ssRvvLekedadees..dYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefa

DYTVRKMHVKLVDSNdqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKG--PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
|..|||..|.  ...     .. | |||||||.||||.|||.|.. |...  ..   |  |..|.|||||||.|||.|||  |....||  .|.  ....
dlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkv

MRQQRMKMVQTADQYIFVNDAVLESVTCGNTQV
.|..|...||| .||.|. .|||| ....|...
lRkkrpgavqteeqYvfiyeavlealdsfndei
Y_phosphatase Protein-tyrosine phosphatase 1-223 6.3e-78 256.8 Pfam-A 14-235 (235) alignment 
Range on Protein: 1-223
Range on HMM: 14-235/235.0
DDNRITLrpmsgH-----KDctneYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWP--DSDTKDYGPFSVT
|..|. |     .     .|    |||| ..| |... ..||||||..||. ||||..|||.  .|||.|.. |.|..||.||||  ..... || ..|.
dktrvkl.....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikve

LN-DEQ-VLTDYTVRKMHVKLVDSNDQPPLMiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI
|  .|.   ..||.||...|  ......  . .|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.|.|.|. .
lkekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeev

DIISIINRMRQQRMKMVQTADQYIFVNDAVLE
|. .|....|.||..|||...||||. .|.||
dvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1-223 6.3e-78 256.8 In-house 14-235 (235) alignment 
Range on Protein: 1-223
Range on HMM: 14-235/235.0
DDNRITLrpmsgH-----KDctneYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWP--DSDTKDYGPFSVT
|..|. |     .     .|    |||| ..| |... ..||||||..||. ||||..|||.  .|||.|.. |.|..||.||||  ..... || ..|.
dktrvkl.....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikve

LN-DEQ-VLTDYTVRKMHVKLVDSNDQPPLMiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI
|  .|.   ..||.||...|  ......  . .|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.|.|.|. .
lkekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeev

DIISIINRMRQQRMKMVQTADQYIFVNDAVLE
|. .|....|.||..|||...||||. .|.||
dvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPRK_pd Subfamily PTPRK 2-246 6.4e-78 256.7 In-house 57-298 (314) alignment 
Range on Protein: 2-246
Range on HMM: 57-298/314.0
DNRITLRPMSGhkDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKdYGPFSVTLNDEQVLT
  |..| .. |  |  ..|||| .|  |    ..|.||||. .|. |||||...|.   |||.|...|.|.||| .|||.  .. ||.. |.| . ..|.
rsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetella

DYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMR
.. || . |. .  . .   .. |..|..||||.|| .||..|.. ||.|.  ....|...|||||| ||||||.|||. |. .|.|| .|.  ..  .|
elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlr

QQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSN
.... ||.| .||.|. |..||.. ||.| .   . . ..  ...
srkvnmveteeqykfiydvileaclcgetaipvsefkalylesir
0047943 (Phosphotyrosine protein) phosphatases II 1-223 1.2e-77 256.4 In-house 51-270 (273) alignment 
Range on Protein: 1-223
Range on HMM: 51-270/273.0
DDNRITLrpmsghKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD---TKDYGPFSVTLNDE
|..|. |      .| .. |||| ... |  . ..|||||| ..|. ||||..|... ..|||.|...| |..|| ||||..    .. ||.|.||| .|
dhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllse

QVLTDYTVRKMHVKLVDSNDqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP--TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIS
..  |||||.. .. .....  ....|..|.|.|||||||.. .|.|.| . ... ..    .||..||||||||||||| |.|. |.| |||||.|. .
etkddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvle

IINRMRQQRMKMVQTADQYIFVNDAVLE
.....|.||. |||| .||.|. .|.||
avkllrsqRpgmvqtpeqyrflyealle
subfamily_PTPRG_pd Subfamily PTPRG 1-238 5.2e-77 254.3 In-house 60-300 (563) alignment 
Range on Protein: 1-238
Range on HMM: 60-300/563.0
DDNRITLRPMSGHKDCTnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|  |..|.|..|.|.   .|||| .|. |  . ..||||||. .|. ||||.||...  |||||||. |.|. ||..|||  ....|| ..||| .|.||
drsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevl

TDYTVRKMHVKL--VDSND--QPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISI
. ||||.. .|   .. ..  .  ....|||.|.||||||||...  |.| .. .   | . ||..||||||||||||....|  |.| ..|  ...  .
alytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgf

INRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNAR
. ..| ||  .||| .||||. ||.|| .. ..|.. . . .
lkhiraqRnflvqteEqYiflhdalleaiasketellaeqve
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 12-223 2.5e-76 251.5 In-house 69-277 (288) alignment 
Range on Protein: 12-223
Range on HMM: 69-277/288.0
GHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDT-KDYGPFSVTLNDEQVLTDYTVRKMHV
...  ...|||| .|...  . .|||||||. .|. |||.|.....   |||.|...|.|| ||..||||.|. | || . ||| ... |.|...||. .
leeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklll

KlvdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQT
.     ..  | ||||....|||||||| .. .|.. | .|.  .   ||..|||||||||||||.|.|. ... |.|  ||........|.||. .|||
e....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqt

ADQYIFVNDAVLE
  ||.|. ...|.
lkqYefiyevlls
DSPc_SM00195 1-224 4.9e-76 250.9 In-house 39-261 (263) alignment 
Range on Protein: 1-224
Range on HMM: 39-261/263.0
DDNRITLRPMSGHkdCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDEQ
|..|. | .  ..   ...|||| .|| .. . .||||||| .||. ||||..|.|. .||||.|.  |.|| ||..|||..  .....| .||.| ...
dhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklveve

VLT-DYTVRKMHVKLVDSndQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
    ....|.....  .   . .  .|||....|||||||. ..|.|.. | .|.... ..||..|||||||||||||..||. |.. |.|  .|| .|.
kkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeiv

NRMRQQRMKMVQTADQYIFVNDAVLES
...|.||..|||| .||.|. .|.|| 
kelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1-224 4.9e-76 250.9 In-house 39-261 (263) alignment 
Range on Protein: 1-224
Range on HMM: 39-261/263.0
DDNRITLRPMSGHkdCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDEQ
|..|. | .  ..   ...|||| .|| .. . .||||||| .||. ||||..|.|. .||||.|.  |.|| ||..|||..  .....| .||.| ...
dhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklveve

VLT-DYTVRKMHVKLVDSndQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
    ....|.....  .   . .  .|||....|||||||. ..|.|.. | .|.... ..||..|||||||||||||..||. |.. |.|  .|| .|.
kkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeiv

NRMRQQRMKMVQTADQYIFVNDAVLES
...|.||..|||| .||.|. .|.|| 
kelRkqRpgmvqtleqYlfiyeailey
0043336 (Phosphotyrosine protein) phosphatases II 1-223 6.9e-76 250.6 In-house 58-275 (278) alignment 
Range on Protein: 1-223
Range on HMM: 58-275/278.0
DDNRITLRPMSGHKDctNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPdSDTKDYGPFSVTLNDEQVL
| .|. | ...|. |  . |||| ... |.   ..|||||| ..|. ||||..|... ..|||.|.  | |.|||.|||| .... ||.|.||| .|..|
dhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehl

TDYTVRKMHVKLvdSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
 |||||...|.     | .....|.||...||||||||  ...|.| ..... ... .||.||||||||||||||.|... |.|.|||||.|. ......
ddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

RQQRMKMVQTADQYIFVNDAVLE
|.||...||| .||.|. .|.||
reqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 1-228 7.5e-76 250.7 In-house 69-292 (297) alignment 
Range on Protein: 1-228
Range on HMM: 69-292/297.0
DDNRITLRPMSGHkDCTNEYINACFIKDYSD-EYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKvKCQQYWPDSDTkDYGPFSVTLNDEQV
|..|. | |. |. |  . |||| ... |.    ..|||||| ..|. ||||..|... ..|||.|. .| |. ||.||||.. .  ||.|.||| ....
dhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkveh

LTDYTVRKMHVKLvdsnDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
| .||||...|.     .......|....|.|||||||......|.| . ... ..  | .||.|||||||||||||| |... |.| |||||.|. ...
ldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleav

NRMRQQRMKMVQTADQYIFVNDAVLESVTCG
...|.||...||| .||.|. ||.|| . ..
kelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPRA_pd Subfamily PTPRA 1-240 2.2e-75 248.6 In-house 71-310 (330) alignment 
Range on Protein: 1-240
Range on HMM: 71-310/330.0
DDNRITLRPMSGHKDctNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
| .|. | ...|...   .|||| ||. | .  ..||.||| . |. ||||.||. .   |||.|.. |  . ||.|||||  .  ||   |...||.||
dfsrvilsvkeGvee..sdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvl

TDYTVRKMHVK-LVDSN-DQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
 ||||||. |. | |.  .... ...|.||||||| |||  .  .|.. ...|.  . . ||. |||||||||||||...|  |.. . |. .|.  ...
vdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvk

RMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIV
|.|.|| .||||  || |.  ..||    |.|..|       
rlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 14-234 2.2e-73 241.9 In-house 73-288 (315) alignment 
Range on Protein: 14-234
Range on HMM: 73-288/315.0
KDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSdTKDYGPFSVTLNDEQVLTDYTVRKMHVKLV
.|   .|.|| ||. |. . .|||.|||  ... |||||...|    |||.||..|. | |...||||     ||...||. .|.| |.|||| . |   
ndphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfg

DsNDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQ
| | .    . |.|.||||| |||.|........|..|   . . |...|||||||||||||...|  |.||| |  ||.  .|...||.|.||||.|.|
d.nir...evvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeq

YIFVNDAVLESVTCGNTQVDS
| |. ||.||.. ||.| .  
yqfiydalletfvcgdtsiaq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2-228 2.5e-73 241.4 In-house 23-245 (250) alignment 
Range on Protein: 2-228
Range on HMM: 23-245/250.0
DNRITLRPMSGHKDCtnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVkCQQYWPDSDTKDYGPFSVTLNDEQVLT
  |. | . .| |..  .|||| |.. |...  .||||||...|..||||....|    |||.||. |..|. ..||||   .. ||   |.| .... .
ssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllskeefa

DYTVRKMHVKlvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
|||.||. .     . .   .. |.||..||| ||||.||..|.. .... . .   ..|..|.|||||||.|.|.|||  |....||  .|.  .|...
dytkrklkls..kakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvl

RQQRMKMVQTADQYIFVNDAVLESVTCG
|..|...|.. .||.||  ..|. ... 
rkdrphavesleqyvfvyeiilkaldsv
subfamily_Ptp69D_pd Subfamily Ptp69D 1-239 2.8e-73 241.7 In-house 61-300 (307) alignment 
Range on Protein: 1-239
Range on HMM: 61-300/307.0
DDNRITLRPMSGHKDCtnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|..|. |... |..|   .|||| ||| | .. ..|| |.|| .|. ||||.|..    .|||..|. |  . ||..|||. |.. ||   |.| .|.  
DktRvkLkkingkeds..dYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekh

TDYTVRKMHVKLVDSND---QPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
.||. |...|  .. .    .    ..|||.|.|.|  ||| |...|.. ..... ||  ..|..|||||||||.|.|.|.|. ||| ..|  .||. ..
sdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetv

NRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARI
  .|.||  .||  .||.|.  |.|.  . |.|..| ..   
kdLrsqRnllvqsleqYvflyralldyssygdtdedvddled
0045450 (Phosphotyrosine protein) phosphatases II 1-223 5.4e-73 241.7 In-house 68-302 (307) alignment 
Range on Protein: 1-223
Range on HMM: 68-302/307.0
DDNRITLRPMSGHkDCTNEYINACFI--------KDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD-TKDYGPFS
|..|. | ...|. . .. |||| ..        . |    ..|||||| ..|. ||||..|...  .|||.|. .| |..|| |||||.. .. ||.| 
dhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnft

VTLNDEQVLTDYTVRKMHVKLVdSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG
||| .|..| .||||...|.   . .......|..|.|.|||||||..  ..|.| ..... .   | .||.||||||||||||||.|... |.| ||||
vtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekeg

G---IDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
    .|. ......|.||...||. .||.|. .|.||
tlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1-230 3.6e-72 237.6 In-house 53-298 (301) alignment 
Range on Protein: 1-230
Range on HMM: 53-298/301.0
DDNRITLRPMSGHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD--TKDYGPFSVTLNDEQ
|||||.|.|..  . |..||||| .|..||.. ..||.|||. .||||||||||||.|  |||.||  |. | ||.||||.|.  ....|||.|||..||
ddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneq

VLTDYTVRKMHVKLVDSND-------------QPPLMITQYHFTSWPDHGV-PEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
|. |...|.. ||. |. .             . .  ..|.. |.||..|| .|..| .   .  |. . |. .||..||||..|.|.|.......|| |
vyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQ

AEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNT
.  || .|.. .....|......|.| .||... |.. . ... .|
ckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
0040439 (Phosphotyrosine protein) phosphatases II 2-223 1.5e-71 236.3 In-house 25-244 (249) alignment 
Range on Protein: 2-223
Range on HMM: 25-244/249.0
DNRITLRPMSGhkDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLT
 .|. | ...|     . |||| .|. |    ..|||||| ..|. ||||..|...  .|||.|.  | |..||.||||..... || |.||| ...|. 
hsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkd

DYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
|||||..... .   |...........|.|||||||..  ..|.| ..... ..  |..||.|||||||||||||| |... |.| |||.|.|. .... 
dytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkl

MRQQRMKMVQTADQYIFVNDAVLE
.|.||...||. .||.|. .|.||
lrsqRpgavqnpeqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 3-227 3.7e-71 235.1 In-house 48-274 (278) alignment 
Range on Protein: 3-227
Range on HMM: 48-274/278.0
NRITlrpmsghkdctnEYINACFIKDYsdEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLTD
.|.             .|||| .|. |    ..||||||  ||. ||||..|... ..|||.|...| |..|| ||||..... ||.|.||| .|.|| |
srVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevldd

YTVRKMHVKLVD--SNDQPPLMITQYHFTSWPDHGVPEYA--TSILQFHRRIKNEYK-------------PTKGPMLVHCSAGVGRTGTFMAIDMGLQQA
||.|...|  .    .| ... .|..|...|||||||..   .|.|.. ..|.. .|             . .||.|||||||||||||. |... |.. 
ytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell

ekEGGIDIISIINRMRQQRMK-MVQTADQYIFVNDAVLESVTC
  |||.|. .... .|.||.  .||. .||.|. ...|| . .
..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0042113 (Phosphotyrosine protein) phosphatases II 1-223 5e-71 234.3 In-house 22-241 (245) alignment 
Range on Protein: 1-223
Range on HMM: 22-241/245.0
DDNRITLRPMSGHKDCTneYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|..|. | |..|. |..  ||||.... |    ..|||||| ..|. ||||..|...  .|||.|.  | |.|||.||||..... || |.||| .|..|
dhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehl

TDYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
 |||||...|. .   | .......||...|||||||..  ..|.|...... .. . .||.||||||||||||||.|... |.|.|||.|... ... .
ddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavke

MRQQRMKMVQTADQYIFVNDAVLE
.|.||...||| .||.|. .|.||
lrsqRpgavqtpsqyrflyealle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-225 1.3e-70 232.7 In-house 54-276 (281) alignment 
Range on Protein: 1-225
Range on HMM: 54-276/281.0
DDNRITLRPMSghKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD-TKDYGPFSVTLNDEQV
|  |... | .  .. ...|||| |.. |..| .|||||||| ..||.||...|...  .|||.|. ||.||.|| .|||| . .  || . |. . |. 
Datrvkvtpne..enkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeee

LTDYTVRKMHVklvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK-NEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISII
 . |  ||...   . .. ..  ..| ..|.|||||||. .. .|.|.. ..  . | || |...|||||||||||..|.|  ....|.|   .|.  ..
katyierkfkl...eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavv

NRMRQQRMKMVQTADQYIFVNDAVLESV
. .|..|. ||||  || ||  |||. .
aelrkernlmvqtvvqyefvykavldal
subfamily_PTPN6_pd Subfamily PTPN6 1-225 6.9e-70 230.5 In-house 67-297 (306) alignment 
Range on Protein: 1-225
Range on HMM: 67-297/306.0
DDNRITLRpmsGHKDCTNEYINACFIKD--YSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD-TKDYGPFSVTLNDE
|..|..|.    ..   ..|||| .||.   . . .|||||| ...|. ||||..|||   .|||.|. .| || || .||||.  ...||  |||  .|
Dhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse

QVLTDYTVRKMHVKLVDSNdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK----GPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---G
. |.||..|...|. .... .    . ||||.||||||||.    .|.| . ...... ..    ||..||||||.||||||. ||. |.. ||.|    
ksladYilRelsvskkkkk.keerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldad

IDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
||| .... .|.||  .|||..|| ||  |. . .
idiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPN12_pd Subfamily PTPN12 1-226 1e-69 229.7 In-house 53-278 (290) alignment 
Range on Protein: 1-226
Range on HMM: 53-278/290.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTK--DYGPFSVTLNDEQ
| .|..|. .....   ..|||| |||  ... .|||.|||.. || ||||.||. .  |.||. ...| || ||..|||..  .   .|.|.|||..|.
dksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeek

VLT-DYTVRKMHVKLVdsndQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGL---QQAEKEGGIDII
 .. |...| ..|.      .   ...|.|.|.|||||||. |.|.|.. . ...  .  . |..|||||||||||| .|||.     ..   .  .|. 
avdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvf

SIINRMRQQRMKMVQTADQYIFVNDAVLESVT
... ..|.||  .||| .|| .|  ||.| |.
dlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 3-232 9.1e-68 223.4 In-house 59-284 (315) alignment 
Range on Protein: 3-232
Range on HMM: 59-284/315.0
NRITLRPMSghKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPD--SDTKDYGPFSVTLNDEQVL
.|. |  .   ..  ..|||| .|| . |.  |||.|||  ... ||||...||..  |||.|.  |. |.||.|||||  .|. ..| ..|.| . .  
arvklevid..dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslead

TDYTVRKMHVKlvDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
|| ..||. ..  .|...    .||..|| |||.||.. ..|.|.. . .| . .. . ..|||||||||||| ...||  ..|....  .|.  ... .
tdgvarklvtr..ksees..rtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknl

RQQRMKMVQTADQYIFVNDAVLESVTCGNTQV
|..|...||| ..| |. ||||| .   || .
rakrpylvqteeeyafiydavledllwrntli
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1-233 1.3e-66 219.4 In-house 46-274 (283) alignment 
Range on Protein: 1-233
Range on HMM: 46-274/283.0
DDNRITLRPMSGhkdctnEYINACFIK---DYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDE
| .|. |.. |       .||||.||    .| .. .||..|.|.  | ||||.....|.   |||.|.. |. ..|| ||||   ..|||.| |||..|
dqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrke

QVLTDYTVRKMHVKLVdSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
     ...... ..   |  .  |... | .  | . |      |...| . | .  .  |||..||||.|.|||..|.|.   ...|  |  .|. ...
ttsnsfiikelllrvn.ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavv

NRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVD
. ||.||| .||| ||| .| ..|||   ||.||. 
kimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 3-223 2.3e-66 218.7 In-house 43-266 (274) alignment 
Range on Protein: 3-223
Range on HMM: 43-266/274.0
NRITLRPMSGHKDcTNEYINACFIKDYSDEY-QYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTK----DYGPFSVTLNDE
 |..|.. |....   .|||| .|| |. |   |.|||||...|. ||||.|.||. ..|||.|.. |. . ||..|.||.        || .... .. 
srvllesessede.dssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikveki

QVLTDYTVRKMHVKLVDSNDQpplmITQYHFTSWPDHGVPEYATSILQFHRRIKNE---YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
    ||.|||. .| . .. .    .. | .|.|||| .|. |...|.. . ....    .   .|..||||||.|||| |.||.....| ..|. .|..
verndysvrklvlkylerers....vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvl

SIINRMRQQRMKMVQTADQYIFVNDAVLE
.|.  .|..|  ||||..|| ..  |. .
kivcnlrldrGGmvqtseqyelihralcl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3-223 5.1e-66 217.2 In-house 22-238 (239) alignment 
Range on Protein: 3-223
Range on HMM: 22-238/239.0
NRITLRPMSghKDCTNEYINACFIKDYSDE-YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKdYGPFSVTLNDEQVLT
.|. |  .|  .|  ..|||| ...||      |||||| |. .  ||||..||||  .|||.| .||  | ||.|||||| .| |  . |||   .|..
srvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.ycnlrvtlrktevfa

DYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMR
|| .| . .  |   ..    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.|.  .||.  .. .|
dyiirtfvmsqvgqtee..ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkair

QQRMKMVQTADQYIFVNDAVLE
..| .||||..||.|.  ||||
edrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3-223 9.9e-66 216.3 In-house 23-239 (239) alignment 
Range on Protein: 3-223
Range on HMM: 23-239/239.0
NRITLRPMSghKDCTNEYINACFIKDYSDE-YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKdYGPFSVTLNDEQVLT
.|. |  .|  .|  ..|||| ...||      |||||| |. .  ||||..||||  .|||.| .||  | ||.|||||| .| |  . |||   .|..
srvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.ycnlrvtlrktevfa

DYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMR
|| .| . .  |   ..    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.|.  .||.  .. .|
dyiirtfvmsqvgqtee..ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkair

QQRMKMVQTADQYIFVNDAVLE
..| .||||..||.|.  ||||
edrphmvqtseqyvfihlavle
0037934 (Phosphotyrosine protein) phosphatases II 1-223 1.5e-65 216.4 In-house 23-240 (243) alignment 
Range on Protein: 1-223
Range on HMM: 23-240/243.0
DDNRITLrpmsghKDctNEYINACFIKDYSdeyQYIATQGPVSSTLVD----FWRLIWQERPPIIVMITNVIEEGKVKCQQYWPdsDTKDYGPFSVTLND
|..|. |      ..  . |||| .|. .    ..|||||| ..|. |    |||..|...  .|||.|. .| |..|| ||||  ... ||.|.||| .
dhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygdftvtlls

EQVLTDYTVRKMHVKLVDSNDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--------YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAeke
|..| |||||..... .| .|.. .....||...|||||||.  ...|.|.. ...         . ...||.|||||||||||||. |... |..    
eehlddytvrtlllenldlddlt.rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...

gGIDIISIINRMRQQRMK-MVQTADQYIFVNDAVLE
 |.|. ......|.||.  .||| .||.|. .|.||
.gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN3_pd Subfamily PTPN3 15-223 3.6e-65 214.6 In-house 62-273 (280) alignment 
Range on Protein: 15-223
Range on HMM: 62-273/280.0
DCTNEYINACFIKDYSDE----YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS-DTKDYGPFSVTLNDEQVLTDYTVRKMH
. ...|||| ...  ..      .|||||||...|  |||...|...  .|||.|...|.|.||| ||||.. |. .|| |||... |.  . | .|.. 
esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelv

VKLVDSNDQPplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQ
.|  .....   .|.|  ...|||||||. ....|.| .|...  . .. |..||||||.|||| ...... |.  |..  . .. |. .||.||. .||
lkdketkeer..kilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvq

TADQYIFVNDAVLE
||.|| || .|.|.
tasqykfvCeailk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 15-232 2.6e-64 212.2 In-house 68-283 (515) alignment 
Range on Protein: 15-232
Range on HMM: 68-283/515.0
DCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPD--SDTKDYGPFSVTLNDEQVLTDYTVRKMHVkl
.  ..|.|| .|. .  .  |||.|||  ... |||||..||..  |.|.|.  |. |.|| .||||  .|.  .| ..| |   .  |. . ||..|  
nPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..

VDSNDqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTAD
. ..|     .||.||| |||.|||. ..|.|.. . .| .    . |...|||||||||| ...||  . .|..   .|.  ... .||.|...||| .
lkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqe

QYIFVNDAVLESVTCGNTQV
|| |. .|||| .   || .
qyafiygavledllwrntli
subfamily_PTPN9_pd Subfamily PTPN9 1-224 3.5e-64 211.7 In-house 55-289 (297) alignment 
Range on Protein: 1-224
Range on HMM: 55-289/297.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWP--DSDTKDYGPFSVTLNDEQ
|. |..|  .....  . .|||| |.  |  .  .||||||.  |  ||||..|...  .|||.| |.|.|..||.||||  . .....| .||.  . .
detrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveve

VLTDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKN-------------EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQA
.  ||.||....| |. ...    .| . |.||||.|||. |.|.|.. . ...             ...|.. |..||||||.||||||...|. |.. 
eeedykvrvleiknvktees..rkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrl

EKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
|..| .|..  ....|.||  ..|| .|| |   |||| 
eevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 3-223 6.8e-64 210.3 In-house 18-237 (237) alignment 
Range on Protein: 3-223
Range on HMM: 18-237/237.0
NRITLRPMSGHkdctNEYINACFIKDYSD-EYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDT-KDYGPFSVTLNDEQVL
.|. |.   .      .||||...|..     .|||.|||. |.  |||...|||.  .|||.| .||  ..|| .|||..|  . || ..|.|  .. .
srvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeef

TDYTVRKMHVKlVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
.||||| . .  .  . .   .| ||.||||||.|||......|.| ..| |. .  .  || ..|||||||||| |. ||  |.||...  .||   . 
sdytvrsllls.krltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvy

RMRQQRMKMVQTADQYIFVNDAVLE
 . ..|  ..|| |||.|.....||
sieedrpyiiqtkdqyvfihqtile
subfamily_PTPN13_pd Subfamily PTPN13 18-225 7.8e-63 207.3 In-house 60-269 (273) alignment 
Range on Protein: 18-225
Range on HMM: 60-269/273.0
NEYINACFIKDY--SDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKD---YGPFSVTLNDEQVLTDYTVRKMHVKL
  |||| .||     |||.|||.|||.  |  |||...|. .  .|.|.|.  |.|||||..|||.|  |    .. . |.| . | | ...||...|| 
ggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkd

VDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTAD
..|..     ... .|..|||||||  |...||| .....  .  .||..||||||.||.||...||. |.  |..  .|.  |....|.||  .||| |
sesges..revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkd

QYIFVNDAVLESV
|||||  |.|| .
qyifvykailevl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-246 1.2e-61 203.7 In-house 74-312 (319) alignment 
Range on Protein: 1-246
Range on HMM: 74-312/319.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITnvieegKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
| |.. |... |      .|||| |.. |  . .|||.|||   || ||||.||. .   ||..|      | || ||||    . .. | | ..  .  
dknvvklerliGee..fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveet

TDYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
 .|.||....   |.. .    |||.||  |||.|||.|.. .... ....     .  . ...|||||||||||.....|. |.. ..|  .|.  ...
aeyvvrdielse.dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvr

RMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSN
 .|||| ..||   || |.  |.||    |...|   .    ....||
dlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2-233 4.6e-61 201.5 In-house 65-292 (297) alignment 
Range on Protein: 2-233
Range on HMM: 65-292/297.0
DNRITLRPMSghKDCTNEYINACFIKDYSDeyQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKvKCQQYWPDSDTKDYGPFSVTLNDEQVLT
 .|..|. .   .|   .|.|| |.| .    ..|.|| |  .|. |||.....|.. .|||...  |. | ||..||.|. .. .|  ||.|.  .  .
ssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsere

DYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPE--YATSILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
 .  |...|.  ..  .   .. ||.|..|||. |..   |.|.|..   ...... ..  |.||||.||||||| ...||  . .|..|  .||  ...
Gfikrelevtkgkakar..rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvk

RMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVD
..||.|...||| .|| ||  |||| . . .|...
klrqerpylvqtkeqykfvyvavleallsedtriq
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-246 4.7e-61 201.8 In-house 38-276 (284) alignment 
Range on Protein: 1-246
Range on HMM: 38-276/284.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITnvieegKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
| |.. |... |      .|||| ||. |  . .|||||||   || ||||.||. .   ||..|      | || ||||    . .. | | ..  .  
dknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsvees

TDYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
 .|.||....   |.. .    |.|.||  |||.|||.|.. .... ....     .  . ...|||||||||||.....|. |.. ..|  .|.  ...
eeyvvrdielse.dgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvr

RMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSN
 .|||| ..||   || |.  |.||    |...|   .    ....||
dlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsn
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-234 1.8e-60 199.8 In-house 63-297 (325) alignment 
Range on Protein: 3-234
Range on HMM: 63-297/325.0
NRITLRPMsgHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLI--WQerPPiIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDEQ
.|. |  .  ..|   .|||| ...|. .   ..|.| | ..|. |.|||.  |.   . .|...|....|| .| .|||.   ..| .|.. | |   .
srvvletk..kddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..cs.vvvvlneldlgkdrcavywpkemgksktfGglevklrtie

VLTDYTVRKMHVKLVDSNDqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY---KP---TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID
 ..||  |...|| |.  .   . . |... ||.| ||... .... . . .|.     .    . .|.||||||||||||.|...   |..  .|  .|
eisdyvhrvldvkqvkkGe..trsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvd

IISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDS
|   ....|..| .||.|.||||.. .|. | . .|||.|  
ifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpv
subfamily_PTPN23_pd Subfamily PTPN23 1-226 2.5e-58 192.2 In-house 56-281 (288) alignment 
Range on Protein: 1-226
Range on HMM: 56-281/288.0
DDNRITLRpmsghkDCTNEYINACFIKDYSDE-YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDE
| ||..||      . ...||||.|.|| |    ..||||.|  ||| |||....... ..|||...  | || |...||| .  .|. .|..||||...
DhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksv

QVLTDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE----YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-D
. .  .  |.....  |..     ...  ..||||..|||.   ..|||   ...      ...| |..|||||||||||.|  .   ... ||. |. |
retethvervlkletldadav..ksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglld

IISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
|| ...|.|.||  |||. .|. |. .|||| . 
iiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4-224 2.6e-58 192.1 In-house 36-263 (270) alignment 
Range on Protein: 4-224
Range on HMM: 36-263/270.0
RITLRPMsgHKDCTNEYINACFIKDYS-DEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTK----DYGPFSVTLNDEQ
|..| ..  ..| . .|||| ... .. .. .|||..||. .|| .|||.||.|. . |||.|.. |.|. ||..||| .  .     .|  .|.   |.
Rvrleel..eedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalsee

VLTDYTVRKMHVKlvDSNDQPPLMitQYHFTSWPDHGVPEYAT------SILQFHRRIKNEYKPT-KG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG
  . | .......  .. ..  |.   .....|||||||. .       ..|.  | ...  | . |. |.|||||||||||||..|.|....  |... 
keegyiltrlrle..ekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkk

IDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
.|...||...|..||..||. .|| |.  ||.| 
vdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_PTPRN_pd Subfamily PTPRN 1-225 4.1e-58 191.4 In-house 69-292 (297) alignment 
Range on Protein: 1-225
Range on HMM: 69-292/297.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSD-EYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQV
|..|..|.  . ..  ...|||| .| |    .  |||||||..||. |||...|..   .||..|.. |||  .|..||||  .. |. . | |  | .
dhsrvklkeeasae..ksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehi

LT-DYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISII
 . || || ...| .....     .||.|| |||..|||  | |.|.| |..   |.    |..||||.|.||||....||. |..  |    |||.. .
wcddylvrsfylknlqtset..rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatl

NRMRQQRMKMVQTADQYIFVNDAVLESV
. .|.|| ..|.| ||. |.  || | |
ehlrdqrpglvktkdqfefaltavaeev
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 3-241 1.2e-56 187.0 In-house 63-295 (439) alignment 
Range on Protein: 3-241
Range on HMM: 63-295/439.0
NRITLRPMSGHKDctNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKvkcqqYWPDSDTKDYGPFSVTLNDEQVLTD
 |.||. . |       |||| .|| | |.  |||||||   |  |||||.....   |||.||..|  |     ||| ..   ||  .|  . .  | .
trvtlqeipgvph..shyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpn

YTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMR
|..| ..|     . .    . |.|...|||. ||  |. .|.| | |.  . |   ||..|||||||||||| .|.|. |.|   |  .||  |.. .|
yvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlr

QQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVF
.|| .|||.  ||.|. .|||| .  |.. |   . .  |
kqrkqmvqalcqyvfiynavledivyGdiavtidefkkef
subfamily_PTPN1_pd Subfamily PTPN1 15-235 1.2e-54 180.0 In-house 53-283 (290) alignment 
Range on Protein: 15-235
Range on HMM: 53-283/290.0
DCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDT-----KDYGPFSVTLNDEQVLTDYTVRKMh
.  |.|||| ...    . .|| ||||...|   ||...|...   .||. .|.|....||.||||  .       .   ..|.|  |..   ||||.. 
radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrll.

vKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQR
 .| . . |    |...|.|.||| ||||  .. |.|  ....    .. .|| ..|||||.||.|||. .|  | . ||..    .||   .  .|..|
.elenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyr

MKMVQTADQYIFVNDAVLESVT--CGNTQVDSR
. ..|||||  |   |.|| .    |.. |..|
lGliqtadqlrfsylaileGakvikgdssvqkr
subfamily_PTPN14_pd Subfamily PTPN14 1-225 2.1e-54 179.6 In-house 62-296 (300) alignment 
Range on Protein: 1-225
Range on HMM: 62-296/300.0
DDNRITLRPMsghKDCTNEYINACFIKDY--SDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS----DTKDYGPFSVTL
.|||. | |    |. ...||||  ||    . |..||..|||.  |. |||...|..   .|||.|. .|.|| |. .|.|..    .| ..| | || 
ednrvelspt...kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvtt

NDEQVLTDYTVRKMHVKLVDSNDQPPLMITQYhfTSWPDHGVPEYATSILQFHRRIK------NEY---KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQA
.  .  . .. .....| . |...  ... ||  | ||||||||  .. |.. ....      |.    | .| |.||||||||||||  .  |. ..  
kfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatl

EKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
|..  ||| ....|.|.||| .|||  || || .......
ehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
0051429 (Phosphotyrosine protein) phosphatases II 18-224 7e-53 175.3 In-house 4-224 (272) alignment 
Range on Protein: 18-224
Range on HMM: 4-224/272.0
NEYINACFIKDYsdeYQ------YIATQGPVSSTLVDFWRLiWQERPPIIVMITNVIEEGKVKCQQYWP------------DSDTKDYGPFSVTLNDEQV
. |||| ... |   ..      .....||   |  ||||| ....   ||..... | |..|| .|||            .  |  || ..|||  |..
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LTDYTVRKMHVKLVDSNDQPpLMITQYHFTSWPDHGVPEYAtsILQFHRRIKNeykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID-------
|.||..|.. ..|. |.... ......|.|.|||||||. |  .|.. . . .     .||.|||||||..||||. |... |.. ..|  .|       
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IISIINRMRQQRMKMVQTADQYIFVNDAVLES
 .  .....|.||...||| .||.|. .|.|| 
yleeaveelraqrpgavqteeqylflyeallel
subfamily_CG7180_pd Subfamily CG7180 1-230 7.2e-52 170.9 In-house 55-295 (296) alignment 
Range on Protein: 1-230
Range on HMM: 55-295/296.0
DDNRITLRPMSGHKDCTneYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKvKCQQYWPDSDTKDYGPFSVTLNDEQVL
| ||. |. . |...    |||| ..  .  . .|| |..|. .|. .||||...|    .|..|.. .  | ....|||    ..||.. | .  |. .
DynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqy

TDYTVRKMHVKLV--------DSNDQPPLMITQYHFTSWPD-HGVPEYATSILQFHRRIKN-----EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE
.. . |.....             . .  .......| |.  . ||  ....... ||..      . .|..||..|..| |..|.| ..|||. |...|
anlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelve

KEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNT
||. .|.   . ..|..| ..|.. ..| .. | .|| | |. .
keeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 11-222 1.4e-49 163.4 In-house 58-274 (287) alignment 
Range on Protein: 11-222
Range on HMM: 58-274/287.0
SGHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDT-KDYGPFSVTLNDEQVL-TDYTVRKM
| . .   .|||| ..  | |. ..||.|||...|. ||||.....|   ....|  .||.. || .|||. .     | .||.| | ...  .|.|| .
saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvral

HVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-----KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQ
 .  .....    .. |... ||||....  | ....|   .|.           ||..||...|.||.|...|. . ... |. | .|.  .. |.|..
rlidletrea..rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlrey

RMKMVQTADQYIFVNDAVL
|  .||.. |. .. .|. 
raalvqavvqlrllyealv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 16-232 1.5e-45 150.3 In-house 71-243 (392) alignment 
Range on Protein: 16-232
Range on HMM: 71-243/392.0
CTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNViEEGKvkcqqywpdsdtkdygpfsvtlndeqvltdytvrkmhvklvds
  ..|.|| .|. .  |  |||.||| ...| ||||...||..  |.|.|.. .||                                            
pdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtkl.kegd...........................................

NDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYI
. .    ..|.||| |||..||....|.|.| . .| ..     |...||||||||||  ..||  . .|.|   .|.. ..  .|..|  |||| .|| 
kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqya

FVNDAVLESVTCGNTQV
|.  |||| .   || .
fiygavledllwrntli
0036282 (Phosphotyrosine protein) phosphatases II 18-219 1.9e-45 150.0 In-house 2-164 (174) alignment 
Range on Protein: 18-219
Range on HMM: 2-164/174.0
NEYINACFIKDYSDEYQYIATQGPVSstlvdFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDsdtkdygpfsvtlndeqvltdytvrkmhvklvdSND
. |||| ... .     .||.||| .     ||.......  ..|| .. .| |..|| .|||.                                   .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

QPPLMITQYHFTSWPDHGVPEYATsILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEkEGGIDIISIINRMRQQRMKMVQTADQYIF
 .  .. ||... |||||||. .. .|.| ..... ..   .||.|||||||||||||..|... |.. . |. .|..... ..|.||..|||| .||.|
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

VND
. .
lyy
0041856 (Phosphotyrosine protein) phosphatases II 17-231 9.7e-45 147.7 In-house 18-177 (182) alignment 
Range on Protein: 17-231
Range on HMM: 18-177/182.0
TNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITnvieegkvkCQQYWPdsdtkdygpfsvtlndeqvltdytvrkmhvklvdsn
 . |||| ..  .    ..||||||  ||. ||.|......  .||..|         . .|||                                    
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp....................................

DQPPLMITQYHFTSWPDHGVPEyATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekegGIDIISIINRMRQQRMKMVQTADQYIF
.  . ...||....|||||||.   ..|.| .....     .|| |||||||||||||. |... ...     |... .... .|..|..||.| .||.|
ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyff

VNDAVLESVTCGNTQ
. .|.|| . ...|.
lqlallellllkktr
0046846 (Phosphotyrosine protein) phosphatases II 19-222 3e-43 142.9 In-house 13-170 (176) alignment 
Range on Protein: 19-222
Range on HMM: 13-170/176.0
EYINACFIKDYsdeyQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDsdTKDYGPfsvtlndeqvltdytvrkmhvklvdsndq
 |||| .|  .     .||||||. .|| ||........  ..|..|. .| |..|| .|||.   ...|                              
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.............................

pplmitQYHFTSWPDHGVPEYaTSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDmglqQAEKEGGIDIISIINRMRQQRM-KMVQTADQYIFV
      ||... |||||||.. . .|.. . |.. .|   || |||||||.|||||. |..      |.| |...  .. ..|.||. ..||| .|| |.
......qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrfl

NDAVL
 ...|
yefel
0049260 (Phosphotyrosine protein) phosphatases II 26-218 1e-42 140.7 In-house 2-143 (152) alignment 
Range on Protein: 26-218
Range on HMM: 2-143/152.0
IKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWpdsdtkdygpfsvtlndeqvltdytvrkmhvklvdsndqpplmitQ
|. |   ...|||||| . || ||||....    .|||.|.  | ||.|| ||.                                             |
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................q

YHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRMKMVQTADQYIFVN
|... |||||||. .  .|.... |.  ..  .|| |||||||||||||..|... |       |...  .....|..|...|.. .|..|. 
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 18-223 1.1e-42 140.7 In-house 81-281 (290) alignment 
Range on Protein: 18-223
Range on HMM: 81-281/290.0
NEYINACFIKDYSdeYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTK--DYGPFSVTLNDEQVLTDYTVRKMhVKLVDS
 .|. | ..|       .| |||.. .| .|.||.. ||.   |||. ..||.|| ||.||.|. . .   .| ..|.   |.   . ...|. . . | 
GdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikkt.lsvrdk

NDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYI
..    ..  ..  ||||. |.  . ..|.  | ...    . ||. ||||||.||||||.||..|||   .   .|.. ..  .|. |.. ||   ||.
dsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyl

FVNDAVLE
 . ...|.
alveilld
0043147 (Phosphotyrosine protein) phosphatases II 18-217 3.9e-42 139.2 In-house 5-153 (172) alignment 
Range on Protein: 18-217
Range on HMM: 5-153/172.0
NEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVieegkvkcqqywpdsdtkdygpfsvtlndeqvltdytvrkmhvklVDSND
. |||| ... |    ..|||||| ..|| ||||.....   .||..|.                                              .   .
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydpe

QPPLMITQYHFTSWPDHGVPeYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRMKMVQTADQYIF
.   .. ||....|||||||  .  .|.| . |..   .  .||.|||||||||||||. |... |       |...  ... .|..|...||. .||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

V
.
l
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 14-223 2.7e-39 129.8 In-house 53-257 (267) alignment 
Range on Protein: 14-223
Range on HMM: 53-257/267.0
KDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEgkvKCQQYWPDS--DTKDYGPFSVTLNDEQVLTDYTVRKMHVK
.. ..||||| ... |  . ..|.||.|.. |  ||. .| ... |.||..|.| ..   . ...||    ..| |  ..|  . |.   || .  . .|
rtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelk

LVDSNDQpplMITQYHFTSWPDHGVPE-YATSIlqFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQT
. . . .    .| |..  |      . |   .  |    ||. .    |..|.||.||||.|||. ||  |..| .||  ||   . ..|.||. .|.|
fknesah...nvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdt

ADQYIFVNDAVLE
 ..||.. . . |
keryiyihellae
PTPc_DSPc_SM00012 123-223 1.1e-37 123.7 In-house 2-105 (105) alignment 
Range on Protein: 123-223
Range on HMM: 2-105/105.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK--GPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMVQTADQYIFVND
...||.|.||||||||...|||.. | .|....  .  .|..|||||||||||||.|.|. ||| ||| . .||  |....|.||..|||| .||.|. .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
0049772 (Phosphotyrosine protein) phosphatases II 3-227 1.9e-37 125.1 In-house 60-282 (314) alignment 
Range on Protein: 3-227
Range on HMM: 60-282/314.0
NRITLrPMSGHKDctNEYINACFIKDYsdeYQYIATQGPVSSTLVDF----------WRLI--WQERPPIIVM---------------------ITNVIE
||  | |  ....    |||| ... .    ..|||||| . |.|||          ||..  .. .. .|||                     .... .
nrvil.pglpvsg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildg

EGkvkcqQYWPDSDTKDYGpfsvtlndeqvltdytvrkmhvKLVDSNDQPPLMITQYHFTSWPDHGVPeYATSILQFHRRIKNEykPTKGPMLVHCSAGV
 |      ... .| ...                       . ..... .. .. .|. . .||...|     ...| . |..   ...|| ||||.||.
ng.....neptaadlellk......................eelydpelferlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGk

GRTGTFMAIDMGLQQAekegGIDIISIINRMRQQRM-----KMVQTADQYIFVNDAVLESVTC
||||||..... . .     |...  .....|..|.      .... .||.|. .|.|| .  
gRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1-223 6.1e-37 122.0 In-house 61-285 (305) alignment 
Range on Protein: 1-223
Range on HMM: 61-285/305.0
DDNRITLRPMSGHkdctnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDtKDYGPF-----SVTLN
|.||. |..   |     ||| | ..   ..  ..| || |.  |  ||| . .|..   | |. |..| |  ||..|..  | ||   |      ... 
dnnrvklegpwph.....eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd.kdvlefeekgqkisvk

DEQVLT-------DYTVRKmHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRriknEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE
 |   |       . .|..  | ...   .  . .|.||.  ||| |||   ..||..      . .|.|||. ||||||.||||. . ..  |.|    
fessvtlkfrkdakakvte.tvlviegpgekarkvthyhwidwpdrgvpaadlailelle....karpskgpivvhcsagigrtgsvvmleyildqllag

GGID-IISIINRMRQQRMKMVQTADQYIFVNDAVLE
  |.    |....|.|| . .|| .||.|| . .|.
qiiedtdkilqkireqrnnsiqtdaqylfvhqviln
0051082 (Phosphotyrosine protein) phosphatases II 18-221 1e-36 121.1 In-house 3-149 (151) alignment 
Range on Protein: 18-221
Range on HMM: 3-149/151.0
NEYINACFIKDYsdeyqYIATQGPVSstlvDFWRLIWQERPPIIVMITNVIEEGkvKCQQYWPDSDtkdygpfsvtlndeqvltdytvrkmhvklvdsnd
. |||. .. ..     .....|| .    ||..|....    ||....  | |  .| .|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

qppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekeggIDIISIINRMRQQRMKMVQTADQYIFV
   . ........|||.|.|..  ..|.|.. . .   . .||.|||||||.|||||..|... |..      ... .... .|..|. .||. .|..|.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

NDAV
  |.
lfal
0044763 (Phosphotyrosine protein) phosphatases II 17-220 5.7e-36 119.2 In-house 17-166 (178) alignment 
Range on Protein: 17-220
Range on HMM: 17-166/178.0
TNEYINACFIKDYsdeyQYIATQGPvsstlVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTkdygpfsvtlndeqvltdytvrkmhvklvdsn
. .||||..| ..     |.....|     .|...|....    ||..|. .| |..|| .|||..                                  
rsdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................................

dqpplmiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekegGIDIISIINRMRQQRMkMVQTADQYIF
        ||... .||||||.    .|.|.. |.. ... .|| ||||||||||.||..|... ...     |... ..|...|..|. .|.. .|. .
.......iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrq

VNDA
. . 
Lyef
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 14-225 1.7e-35 117.4 In-house 55-270 (285) alignment 
Range on Protein: 14-225
Range on HMM: 55-270/285.0
KDCTNEYINACFIKD-YSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLND--EQVLTDYTVRKM
|.   .|| | ...    |.  ||.||||.  || |||..|.||.   ..|.  ..| |  ||  |.|.   .   .| . .|| .  |. ..   .  .
knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnal

HVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMV
 |   .     || . . .   |||.  || |  ...... .|.  .| . |. |||||||||| ||. ||    .  ..  |... |.  ||  |.. |
tvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqav

QTADQYIFVNDAVLESV
|.  |..|.   ..| .
qshmqflflyvvlmeyf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4-223 1.9e-35 116.9 In-house 53-267 (281) alignment 
Range on Protein: 4-223
Range on HMM: 53-267/281.0
RITLRPMSGHKDCTnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD--TKDYGPFSVTLNDEQVLT
|. |.     |. | .|| | .|.    .  || ||||   |  ||||.||||    |||. ...|  . || .|.|       ..  .||. .|  |  
rvqlkvkmpnknst.dyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnk

DYTVRkmhvKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINRM
         .|  | .    .||.. .  |||  ||| .  .|.  |.|.        | ..||||||||.||.||... ||       . ||  |. ..
slvtt....rlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarst....ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshl

RQ-QRMKMVQTADQYIFVNDAVLE
|   |   ||| .||...   .|.
rvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 16-223 4e-35 116.3 In-house 65-275 (307) alignment 
Range on Protein: 16-223
Range on HMM: 65-275/307.0
CTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDT--KDYG--PFSVTLNDEQ---VLTDYT-VRK
 . .|| | ..    .  ..|..|||  .|  .|| .. ||.   ..|. .||| .|.||.||||  .   . .|  | ......     .  |   .  
lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinv

MHVKLVDsnDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQ-AEKEGGIDIISIINRMRQQRMK
  .|..    |    |... .. |||.|||.   . . .   .. .    . |..|||||||||.|| .|| .  ..  . .   |.  ... .|.||  
ttlkvdw..aqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhy

MVQTADQYIFVNDAVLE
 .||  ||...   .||
aiqteaqylylhrvlle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 15-227 6.7e-34 112.2 In-house 64-273 (288) alignment 
Range on Protein: 15-227
Range on HMM: 64-273/288.0
DCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDEQVLTDYTVRKMHVKL
| .. ||.|  .     . . | .| |. .|.  .|... ..    |||.....| || | ..|.|    ..  .| .     ....  | .|.   .. 
ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllri

VDSNDQPPlMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTAD
    ...  .. . |.  |.|.||||   | |..  ..|.  |    |..||.|||||||||.. | . |...  .  . | |.....|..|.| .||  
skegeekv.ivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtem

QYIFVNDAVLESVTC
||..|   ||| .  
qylyvhrcvleelll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 14-222 7.1e-34 111.8 In-house 75-287 (310) alignment 
Range on Protein: 14-222
Range on HMM: 75-287/310.0
KDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS-DTKDYGPFSVTLNDEQvLTDYTVRKMHVKL
|   ..|| | ..|       .| .|||.  |..||||.|.|||   |... .| |||. ||  |||    |. ||   ||   |    .. . .. | .
ksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlses.seefeicnlavtf

VDSN----DQPP----LMITQYHFTSWPDHGVPEYATSILqfHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
|  |    .||     | ..  ..  ||| |||.     .   .|.  . .  .|| .||||||..|... .|... ......   .|.  ..  ....|
vpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv..pqrllaqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksr

MKMVQTADQYIFVNDAVL
.. .||  ||....   .
aiciqtelqyliidrvri
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 20-217 8.6e-33 108.4 In-house 77-273 (301) alignment 
Range on Protein: 20-217
Range on HMM: 77-273/301.0
YINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD--TKDYGPFSVTLNDEQVLTDYTVRKMHVKLVDSND
 | | .|.   .  ..||||||...|  ||| .. |     |||... .|. . ||..| | .   . | | |.......... .  . | .....|| .
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

Q-PPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIF
. ..  .| | ...|.|.|||.  . . ..   .|.    .. |..||||||.||. .|.. ..  .. | .  |..   ....|..| . |||  |  .
kfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw

V
.
m
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 17-222 1.7e-31 104.0 In-house 79-286 (305) alignment 
Range on Protein: 17-222
Range on HMM: 79-286/305.0
TNEYINACFIK-DYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLND-----EQVLTDYTVRKMHV
  .|| | ..      | ..|..|||.  |. .|| .. |..   |||. . .| ||.|| |||| .  .     |  . .       .  |  ..   .
psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitll

KLVDSNDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQ-AEKEGGIDIISIINRMRQQRMKMVQ
.|  | ||  . . . ..| ||| |||    . |..   |.     .| |..||||||.||||| .||.  |.. ||.     .  ... .|.||   .|
nltysgdq.kmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiq

TADQYIFVNDAVL
.  ||.|.   .|
ndvqylfihrvml
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 123-232 2.3e-31 103.6 In-house 91-201 (440) alignment 
Range on Protein: 123-232
Range on HMM: 91-201/440.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAV
. |||. .|||.|||..|  .|.. . ... . |  .||.|||||||.||||  .|.|  |..|..   |||.|.|| ||..| .|||| .|| ||..||
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

LESVTCGNTQV
||.. ||.| .
legllcgdtli
subfamily_ptpA1_pd Subfamily ptpA1 17-178 2.1e-30 100.8 In-house 74-249 (418) alignment 
Range on Protein: 17-178
Range on HMM: 74-249/418.0
TNEYINACFIkDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDygPFSVTLNDEQVLTDYTVRKMHVK-----
 ..|||| .| | .   |.|.||||.  |. ||||..|..|  ||||..   |. ..||..|||.    .   ||.  | ..|.  |.|  . |      
gsdyinanyi.dgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge..qfsiygngnevfgtysvelveviqdper

-LVDSN-----DQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY---KPT---KGPMLVHCSAGVGRTGTFMAI
 ..  |     .     ||||..  |||| .|...  . |. . | |      |.   . |..||||||||||||| . 
eiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfcta
0048076 (Phosphotyrosine protein) phosphatases II 87-221 2.9e-29 97.0 In-house 13-139 (145) alignment 
Range on Protein: 87-221
Range on HMM: 13-139/145.0
YGPFSvTLNDEQVLTDYTVRKMhVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDMGLQqae
.|..  | .| . | |. ..   . | .  . .  ...||....|||||||. .  .|.| . |.. .|   ||.|||||||||||||..|... |.   
lgslp.taldlellkdlgittv.lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll...

keGGIDIISIINRMRQQRMKMVQTADQYIFVNDAV
   |... ......|.||...|.. .|..|. ...
..lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 39-217 7.8e-29 95.1 In-house 97-280 (302) alignment 
Range on Protein: 39-217
Range on HMM: 97-280/302.0
QGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLND-EQVLTDYTVRKM------HVKLVDSNDQPPLMITQYHFT
  |  |||  .| || | .  |.| .....|... || .|. |   ..  .| ..|.  . .. | ..| .|        .|    ... .  .   .|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

SWPDHGVPEYATSILQFHRRIkNEYKptkGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFV
.||||| |. | . |.  .   . ||     .|||||||||||||..||  |.|   |.   |..||.  .|| |   ||...| |..
awpdhGapkeaytaldilkfc.esyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 33-217 1.6e-28 94.2 In-house 5-196 (199) alignment 
Range on Protein: 33-217
Range on HMM: 5-196/199.0
YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPD--SDTKDYGPFSVTLNDEQVLTDYTVRKMHvkLVDSNDQPP--LMITQYHF
 .||||| |.  |. |||...|.     |||. .   . ..    |||   | |  || .||| .   .  |||.  .   |...   ||    |..| |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitali..ltnnttappstreishyqf

TSWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMKMVQTADQYIFV
||| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  .. . ..| |.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 33-217 1.9e-28 94.0 In-house 4-195 (198) alignment 
Range on Protein: 33-217
Range on HMM: 4-195/198.0
YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPD--SDTKDYGPFSVTLNDEQVLTDYTVRKMHvkLVDSNDQPP--LMITQYHF
 .||||| |.  || |||...|.     |||. .   . ..    |||   | |  || .||| .   .  |||.  .   |...   ||    |..| |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitali..ltnnttappstreishyqf

TSWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMKMVQTADQYIFV
||| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  .. . ..| |.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
0048179 (Phosphotyrosine protein) phosphatases II 108-218 2.9e-28 93.8 In-house 32-138 (144) alignment 
Range on Protein: 108-218
Range on HMM: 32-138/144.0
MHVKLVDSNDQPPLM--ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekEGGIDIISIINRMRQQRM
. . |... ... |   ..||....|||||||.... .|.| . |.. ..  .||.|||||||||||||..|... .     . |... ......|..|.
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrp

KMVQTADQYIFVN
 .|.. .|..|. 
gavpnpgqlrfLl
subfamily_CG42327_pd Subfamily CG42327 14-153 1.6e-26 87.7 In-house 52-193 (319) alignment 
Range on Protein: 14-153
Range on HMM: 52-193/319.0
KDCTNEYINACFIKDYSDE-YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKD----YGPFSVTLNDEQVLTDYTVRKM
.|  .||..| ... | |   .|||.| .  ..  ||||..|. .  .|| .|.. | |  .| .|.| ..| |    || . ||| . .|   | .  .
dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistl

HVKLVDSNDQPPlmITQYHFtSWPDHGVPEYATSILQFHRRIKNE
 .| || .   .  .| | .  |.. .||   ....    .... 
llkrvdkeesre..lthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 17-226 6.8e-26 85.7 In-house 66-277 (312) alignment 
Range on Protein: 17-226
Range on HMM: 66-277/312.0
TNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSdtKDYgpfsVTLNDEQVLTDYTVR----------
 | || | |.|  .   ....||||. .| . ||.|        |.... ..|.|  || .|  |     .    | |.| .| |.|             
enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi..vgf....vdledhrvyteycteieiggkskdk

--KMHVKLV-DSNDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQ
  .  .|.|  .  |    . .| ..||||||.|.   . |..   .|..    | |.. |||||||||||.. |.  .    .    ..  .   .|..
ithrvlkvvvkatgq.esklnhyqwaswpdhgmpdscdtalrllsavkkd....kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkd

RMKMVQTADQYIFVNDAVLESVT
| . |..  ||...  .||| . 
rarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 14-222 3.2e-25 83.8 In-house 42-256 (290) alignment 
Range on Protein: 14-222
Range on HMM: 42-256/290.0
KDCTNEYINACFIKdYSDEYQYIATQGPV-------SSTLVDFWRLIWQERPPIIVMITNVIEEGKV----KCQQYWPDSDT--KDYGPFSVTLNDEQVL
|  ...|| | ... ...  . |.|| |         ||. .|| .. ||.   .||. .. |. .      |..| |.|      .. ..|   .    
krfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskeke

TDYTVRKMHVKLvdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAE-KEGGIDIISIINR
 |  .|.. ||    .|. .. .| . . .| .  |.|   ..|.  . .|..    | |..|||  |. |  .. ||..| |    ..| . . .... 
ddvetRelvvkf...ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlka

MRQQRMKMVQTADQYIFVNDAVL
.|.|| .....| .. ||  ...
lrkqralaitsalelafvdagiv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1-147 4.7e-25 83.1 In-house 46-190 (297) alignment 
Range on Protein: 1-147
Range on HMM: 46-190/297.0
DDNRITLRPMSGHKDctneYINACFIK--DYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDE-
||.|. |.     .|    |||| ..   |   ...|| .|||.|.|. |||.|....   .|||.... |.|. ||  |||... .     .| ..   
ddtrvkllrviterd....yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvvefls

QVLTDY-TVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFH
..  .. .|    ..|.  ...   ...   | ||||||||     . .|.
stsdefdrviltelqliyrses..rvvrhvqflswpdhGvpsdledlvrfq
subfamily_egg_pd Subfamily egg 16-245 3.8e-23 76.6 In-house 66-293 (307) alignment 
Range on Protein: 16-245
Range on HMM: 66-293/307.0
CTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEgkVKCQQYWPDSDT--KDY--GPFSVTLNDEQVLTDYTVRKMHVK
 ....| |  .|      ..| .| |.  |  ||||...||. . |||.|   |    .|. ||| ...    .  | . ..  . .  .|   |  ..|
ylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklk

LVDSNdqpplmITQYHFTSWP-DHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMAIDMGLQQAEKEgGI---DIISIINRMRQQRMKM
|| ..        . .   |  |        | |.  |...|  |    |..|..  || ...|..||.. | .  .   |    .   .  .|..|   
lvGgd......deerflehwqgdvnnssdvysplrvlrklrnlsk....pvvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrls

VQTADQYIFVNDAVL---ESVTCGNTQVDSRNARIVFNRMS
|... .|.||   ||     |     ..|    | . .|  
vesvllylfvyrlvlfffrdvigsakeldvdyerwleerse
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 44-225 2.7e-22 74.1 In-house 39-221 (255) alignment 
Range on Protein: 44-225
Range on HMM: 39-221/255.0
STLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSI
 |.  |.. | | ..  .||...  |||..||..|.|    .      |..   .  .|  .| ... .  .. .    .. |... |...  || |  |
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
|.  . ...  |    ...||||.|.||. .|. ...  |      .  . ...| .|... .|..| . ..|  |  |    ||. |
lnilkvvrds.k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 15-218 2.2e-20 67.3 In-house 72-278 (302) alignment 
Range on Protein: 15-218
Range on HMM: 72-278/302.0
DCTNEYINACFIKDYSDEYQYIATQGPVSSTL---VDFWRLIWQERPPIIVMITNVIEEGKvKCQQYWP--DSDTKDYGPFSVtlNDEQVLTDYTV-RKM
 . ..|.||  ..  . ... | .| |....     .|||...||.   .|..    |  |   ....|    | |.|| . |  |  .|        . 
aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfv..NnrkVekaeeektry

HVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMV
 . ..  .    .... |..| |... ||.  ... .    . ..  ... ....    |.|| |.|..  . ... .|.    |  |.. .|.|| ..|
viEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRprav

QTADQYIFVN
....||... 
dslkQyvsly
subfamily_hpo-7_pd Subfamily hpo-7 44-229 4.3e-19 63.4 In-house 45-231 (263) alignment 
Range on Protein: 44-229
Range on HMM: 45-231/263.0
STLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSI
 |.  |.. | | ..  .||...  |||..||..|.|    .      |..   .|  |  ..  ..  . .. .    ...| .. |...  || | .|
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGN
|.  .  .|  |    .. ||||.|.||.  |  ...  |      .  . ...| .|... .|..| . ..|  |  |    ||. |   .
lnilkvarns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 107-222 5.3e-19 63.1 In-house 204-341 (350) alignment 
Range on Protein: 107-222
Range on HMM: 204-341/350.0
KMHVKLVDSNdqpPLMITQYHFTSWPDHGVPEYATSILQFHR--------RI-KNEYKPT-KGPMLVHCSAGVGRTGTFMAIDMGLQQ------A-EK--
 . ..|  |.   |... | ..  |.| ..     ||||            . .. ..     |.|||||||||||||....|. |..        ..  
ltaitlaasd...PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesr

-----EGGIDII-SIINRMRQQRMKMVQTADQYIFVNDAVL
         |.|  |.|..|.||..|||. ||.||. .|.|
kldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 13-86 7.1e-19 62.7 In-house 78-157 (350) alignment 
Range on Protein: 13-86
Range on HMM: 78-157/350.0
HKDCTNEYINACFIKDY------SDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKD
|   ||.|||| ..|          ...|||||.|. ||. ||...| .   ..|...|. .| .  ||..||.. . .|
hslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydd
subfamily_CG42327_pd Subfamily CG42327 155-219 4.2e-17 56.8 In-house 244-309 (319) alignment 
Range on Protein: 155-219
Range on HMM: 244-309/319.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMVQTADQYIFVND
.  .||. |||| ||||||. .| |. ... |.    .||  ..  .|..| . |.| .|| |.  
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 161-228 1.6e-15 51.3 In-house 1-68 (69) alignment 
Range on Protein: 161-228
Range on HMM: 1-68/69.0
MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCG
|.||||.| ||||||.|| . . .   |  .||   .. ||. |  ||    .|||. ||. |..  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 163-228 6.5e-15 49.2 In-house 2-67 (69) alignment 
Range on Protein: 163-228
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCG
||||.| ||||||.|| . . .   |  .||   .. ||. |  ||   ..|.|. ||. |..  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 155-225 1.4e-14 48.7 In-house 225-295 (297) alignment 
Range on Protein: 155-225
Range on HMM: 225-295/297.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
.| . ..||||||||||.|  .  |. |..  |.   |. .|.. .|.|| ..||| .|. .. ||||. .
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 118-223 1.5e-13 44.8 In-house 215-342 (349) alignment 
Range on Protein: 118-223
Range on HMM: 215-342/349.0
QPPLMITQYHFTSWPDHGVPEYATSILQFHRrIKNE----------YK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQ---QAEKE--------GGIDIIS
. | .. |  .  |.| ..     ||||    .||.          ..     ..||||||| ||||... .|. |.     ..|           |.||
ekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

-IINRMRQQRMKMVQTADQYIFVNDAVLE
 |.| .|.||. |||   |.|.. .|.|.
iivnelrkqrismvqnlaqfiaiyealLk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 17-83 2.5e-13 44.1 In-house 89-157 (349) alignment 
Range on Protein: 17-83
Range on HMM: 89-157/349.0
TNEYINACFIK--DYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD
 ..|||| ..|   .| | .||||| |. ||. ||...|  .. .... ...  |..  ||..|| . .
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 18-225 3.6e-13 43.8 In-house 69-279 (303) alignment 
Range on Protein: 18-225
Range on HMM: 69-279/303.0
NEYINACFIkDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPD-SDTKDYGPFSVTLNDEQVLTDYTVRKMHVKLVdSN
  || | .. .   . . | || |.| |  |||..| ...   ....    |  |.  .  .|   |  ..   |. . . . .      ...|  | ||
ssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsv.sn

DQPPLMITQYHFTSWPDHGVPEY-----ATSILQFHRRIKnEYKPTKGPMLVHCsAGVGRTGTFMAIDMG-LQQAEKEGGIDIISIINRMRQQRMKMVQT
 .   ..  .|. .||   .|          | |    ..  | ... .. .   .|.||.|||  ..   |   ...  .|..  .. .|. |.. || 
gdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlr.kysdstptvymsl.sgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqn

ADQYIFVNDAVLESV
  |. .|   . | |
lsqfsvvytllaehv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 14-136 1.7e-12 41.5 In-house 118-235 (244) alignment 
Range on Protein: 14-136
Range on HMM: 118-235/244.0
KDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEgkvkcQQYWPDSDTKDYG--PFSVTLNDEQVLTDYTVRKMHVK
    | |||| |.       .|| || |.. | .|||... .    ..|..  | ||     ..|||||.  ..     .||| | . . .    .. ..
gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleie

lVDSNDQpPLMITQYHFTSWPDHGV
  | |.     .| .  . ||  | 
.sdmnes.hqaltmfqisnwpsdgt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 26-112 9.2e-12 39.0 In-house 229-313 (440) alignment 
Range on Protein: 26-112
Range on HMM: 229-313/440.0
IKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEgkvKCQQYWPD-SDTKDYGPFSVTLNDEQVLTDYTVRKMHVKL
.. ||    .|||| |. ||..|||||. . |   |.|. .. .     |  |||  . .  .|||.|  .  . .    || . .| 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelky
subfamily_eak_pd Subfamily eak 17-150 4.2e-11 36.8 In-house 77-207 (332) alignment 
Range on Protein: 17-150
Range on HMM: 77-207/332.0
TNEYINACFIkDYSD-EYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD--TKDYGPFSVTLNDEQVLTDYTVRKMHVKLV
 . ||||  . ..|.   .|| |  .  . .  ||... ... | ||.. . .|..  | ..|.||      ..| . |.  .      . .|.. ..  
rlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskG

DSNDQpplmITQYHFTSWPDHGVPEYAtSILQFHRRI
.   .    .  |..  | .  .| |    | ... .
nethr....vlhykvfGwtettlpkye.dflalrkvm
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 17-135 3.4e-10 34.3 In-house 12-125 (130) alignment 
Range on Protein: 17-135
Range on HMM: 12-125/130.0
TNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEgkvkcQQYWPDSDTKDYGPF--SVTLNDEQVLTDytVRKMHVKLVD
 |.|||| |.       .|. || |.. | .|||... .    ..|..  | ||     ..|||||.  ..      ||| | .      ..  ...  .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkn..ikasnleies

SNDQPPLMITQYHFTSWPDHG
   .    .| .. . ||  |
dlneshqaltmfqisnwpsdg
0038934 (Phosphotyrosine protein) phosphatases II 125-213 1.9e-09 32.9 In-house 81-165 (194) alignment 
Range on Protein: 125-213
Range on HMM: 81-165/194.0
QYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMglqqaEKEGGIDIISIINRMRQQRMKMVQTADQ
.|.   .||.|..     .|.| . ..  ..  ..|  .||| ||.|||||. |  .      .  |..    |...|. | ..... |.
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdy
subfamily_PTPDC1_pd Subfamily PTPDC1 126-219 2.4e-08 28.6 In-house 85-170 (182) alignment 
Range on Protein: 126-219
Range on HMM: 85-170/182.0
YHFTSWPDHGVPEYaTSILQFHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAekeggIDIISIINRMRQQRMKMVQTADQYIFVND
..  .|.|.||.   ..||.  . ..   .  .| . ||| || ||||  .|  .  ..      ..    |. .|..| | .|| .|  .|..
vynfgwkDygvasl.eriLdivkvvafalq..egkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 11-69 4.7e-08 26.9 In-house 63-121 (347) alignment 
Range on Protein: 11-69
Range on HMM: 63-121/347.0
SGHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIE
 .. | .. ||||  ||    . .|| || |. .|. |||...   .   .| | . |.
nsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepik
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 74-222 1.7e-07 25.0 In-house 149-299 (332) alignment 
Range on Protein: 74-222
Range on HMM: 149-299/332.0
KCQQYWPDSD-TKDYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMitqyHFTSWPDH-GVPEYAT----S-ILQFHRRIKNEyKPTKGPMLVHCS
 |...||.    ||.  .|.  .|..  |     .. |     . |  ||    ||  | |   .|||      |  ||. |  |.      ||... |.
icrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlm....hfyewadasklpeymldmrasiklqyirsskkt.gvcigpimlvca

AGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVL
.|| .   . .||. . .  .|  . .   .. .. ||.  ..|   |    . ..
tgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlm
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 5-224 2.5e-07 23.6 In-house 85-308 (346) alignment 
Range on Protein: 5-224
Range on HMM: 85-308/346.0
ITLRPMSGHKDCTNEYINAC--FIKDYSDEYQYIATQGPV---SSTLVDFWRLIWQERPPIIVMItnvIEEGKVK--CQQYWPDSDT-KDYGpFSVTLND
|||. .| .  |   |..    ..  .  |.. | .| |     | . ||| .|.||.  .. ..   . . |.|      . | .   .|    . .|.
itlkdvsrrmacvpayvhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylm...vpddklkntttslfndenggyqyt.gkmfinn

EQVLTDYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISI
 .       ..  ....   .   ..   .| . |     |  .  |...  ... | .  .  . |    | ||. .|.     ..| .     .|. |
rradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepnicei

INRMRQQRMKMVQTADQYIFVNDAVLES
.  ..|||   |..  ||  .   |.. 
mknikqqrpggvesfaqyasiyaivfdy
PTEN_1 125-175 2.8e-07 25.6 In-house 96-147 (196) alignment 
Range on Protein: 125-175
Range on HMM: 96-147/196.0
QYHFTSWPDHGVPEYAtSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTF
.|.  ...|||.|  . ... . ..... ..  | ..  |||| ||.||.|| 
eylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtv
subfamily_eak_pd Subfamily eak 155-232 7.2e-07 22.9 In-house 234-312 (332) alignment 
Range on Protein: 155-232
Range on HMM: 234-312/332.0
KPTKGPMlVHCSAGVGRTGTFMAIDMGLQ--QAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQV
 |.  |. . .. |  |.|.|. ||. ..  .. |.    .  .| .....|.. | .| |. |. ..||. .   | ..
ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrl
PTPlike_phytase Inositol hexakisphosphate 124-178 1.2e-06 23.2 Pfam-A 93-144 (149) alignment 
Range on Protein: 124-178
Range on HMM: 93-144/149.0
TQYHFTSWPDHGVPEYAtSILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAI
 .|.    .|.  || .  . .| | ||.   |..  ....|.|| ||| |.|.|
vkYvRipitdeqapeee.dvDafvrliksl..prdtalvfnCqaGrgRTTtamvi
PTPlike_phytase Inositol hexakisphosphate 124-178 1.2e-06 23.2 In-house 93-144 (149) alignment 
Range on Protein: 124-178
Range on HMM: 93-144/149.0
TQYHFTSWPDHGVPEYAtSILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAI
 .|.    .|.  || .  . .| | ||.   |..  ....|.|| ||| |.|.|
vkYvRipitdeqapeee.dvDafvrliksl..prdtalvfnCqaGrgRTTtamvi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2-74 2.6e-06 21.1 In-house 48-117 (332) alignment 
Range on Protein: 2-74
Range on HMM: 48-117/332.0
DNRITLRPMSGhkdcTNEYINACFIKDYSDEYQYIATQGPVSS-TLVDFWRLIWQERPPIIVMITNVIEEGKVK
 .|. | |  |     ... || ..  || .  || .| |.   |   |||.. . .| .|... .. |. | |
hsrvelapqdg....kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_CDKN3_pd Subfamily CDKN3 111-219 2.7e-06 21.1 In-house 90-190 (202) alignment 
Range on Protein: 111-219
Range on HMM: 90-190/202.0
KLVDSNDQPPLMItqyHFTSWPDHGVPEYATsILQFHRRIKNEYKPTKGpMLVHCSAGVGRTGTFMAIDMgLQQAEKeggIDIISIINRMRQQR-MKMVQ
.|.|   |  |..   |    .| .||. |.  |..   ..   |  ..  ||||  |.||.   .|  . |   .    |.    |...|. .  . .|
rlldlyqqagliv...hhypiadglvpdias.clkileelrinlkayrk.tlvhcygglgrsslviacll.lylddt...iepkdaidklrdlkgsraiq

TADQYIFVND
|  || ....
tvkqynylse
subfamily_DSP23_pd Subfamily DSP23 131-219 2.8e-06 22.1 In-house 59-140 (148) alignment 
Range on Protein: 131-219
Range on HMM: 59-140/148.0
WPDHGVPeYATSILQFHrRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMglqqaEKEGGIDIISIINRMRQQRMKMVQTADQYIFVND
 .|.  |     . .|  |. .| .  .  . |||  | |||||..|  .      || ..     |  .|..|   |.| .|   | |
iddyhpp.aleqvvefv.rvveeaeekneavsvhcllgrgrtgtmlacyl.....vkerklaaaeaiaevrrlrpgsvetveqeklvrd
PTPc_motif_SM00404 149-177 5.8e-06 21.3 In-house 72-99 (140) alignment 
Range on Protein: 149-177
Range on HMM: 72-99/140.0
RIKNEyKPTKGPMLVHCSAGVGRTGTFMA
 |.|  . ..|  |||| ||| |..|...
fiena.ekkggkvlVHCqaGvSRSatlii
Y_phosphatase3 Tyrosine phosphatase family 147-182 9.5e-06 20.7 Pfam-A 113-148 (164) alignment 
Range on Protein: 147-182
Range on HMM: 113-148/164.0
HRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGL
 |.. .    ..||.|.||.||  ||| ..|. . |
yrkvlealaeeegpvlfHCtaGKDRTGvvaalllsl
0048567 (Phosphotyrosine protein) phosphatases II 126-178 9.7e-06 20.0 In-house 40-97 (157) alignment 
Range on Protein: 126-178
Range on HMM: 40-97/157.0
YHFTSWPDHGvPEYATSILQFHRRIKNEY---KPTKGPMLVHCSAGV---GRTGTFMAI
.... . |.| |   . . .| ..... .   . ....  |||.||    |||.|... 
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc