Gene PTPRD-15 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP068_AA protein Get Run
AqueP068_AA_0-226 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-230 7.3e-113 371.2 In-house 59-288 (290) alignment
Range on Protein: 1-230
Range on HMM: 59-288/290.0
DDNRITLRPMSGHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|||||||||.||||||||||||||.||.|....||||||||||.||||||.|||||. .||||.||.||||||||||||||||||.||.||..|..|..|
ddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetl

TDYTVRKMHVKLVDSNdQPPLMITQYHFTSWPDHG-VPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
..|. ||..||  .|. ... ..|||..|.|...| |....|..|......|...|.......||||..|||...|.|..........||.||.......
neyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlks

MRQQRMKMVQTADQYIFVNDAVLESVTCGNT
.|.|....|||..|| .... ||..... .|
qRiqkpgsvqtvqqyqgifqivltyldsfet

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-234 1.4e-101 334.2 In-house 60-287 (287) alignment
Range on Protein: 1-234
Range on HMM: 60-287/287.0
DDNRITLRpmsghkDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|..|. |.      .. ..||||.||. |......|....|...|...||.||.......|||...  |. . .| ||||....  .|.....| .|.| 
dnyrvllk......gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevn

TDYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHG-VPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
..|..||..||  ...........||..|.|...| |.|..|..|......|...|.......||||..|||...|.|..........||.||.......
agyierklevkn.knkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlks

MRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDS
.|.|....|||..||.|.||.|||......|..|.
qriqkpgsvqtveqykfindivleyldsfetysdf

subfamily_PTPRD_pd Subfamily PTPRD 1-243 8.1e-100 330.1 In-house 61-299 (564) alignment
Range on Protein: 1-243
Range on HMM: 61-299/564.0
DDNRITLRPMSGHKDCtnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
| .|. |... |....  .|||| ||. |  . .|||||||...|. ||||..|...  .|||.|.. |.|||||..|||...|. || . |||..|. |
dhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeel

TDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
.||..|.. .|  .|...   ...|.||||||||||||.|||.|.. |....  .|..||..|||||||||||||..||. |.....|. .|| ......
adyeirtfklkkkksses..reVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkal

RQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNR
|.||  |||| .||||. .|.|| ..||||.|.|.| .  ...
rkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-245 3.6e-96 316.9 In-house 59-303 (305) alignment
Range on Protein: 1-245
Range on HMM: 59-303/305.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTK--DYGPFSVTLNDEQ
||.|| |.. . ..   ..||||.... |. . .||..|||. .|..||||||..|..  |||.|...|.|| ||.||||.| |.  ..|.|||.|..|.
dddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksek

VLTDYTVRKMHVKLVDSnDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
  .||. ||...   |. |.    ..||..|.|||||||..|||.|.. .|.....|  || |.||||||||||||.|.|.|. |....||. .|.  ..
tasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevl

NRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMS
...|..||||||| ||| |. ||. | .|||.|..   | |.  |.. 
kqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk

0051299 (Phosphotyrosine protein) phosphatases II 1-224 3.9e-83 274.5 In-house 62-285 (288) alignment
Range on Protein: 1-224
Range on HMM: 62-285/288.0
DDNRITLRPMSGhkDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|..|. |....|  . .. |||| .|. |  . ..|||||| ..|. ||||..|... ..|||.|...| |..|| ||||..... ||...||| .|.||
dhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevl

TDYTVRKMHVKLV--DSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
 |||||...|. .   . |. ....|..|.|.|||||||......|.| |.... .....||..||||||||||||| |.|. |.| |||||.|. ....
ddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavk

RMRQQRMKMVQTADQYIFVNDAVLES
|.|.||. |||| .||.|| .|.|| 
rlreqRpgmvqtpeqyrfvyealley

0050432 (Phosphotyrosine protein) phosphatases II 1-229 4.4e-83 274.5 In-house 81-303 (308) alignment
Range on Protein: 1-229
Range on HMM: 81-303/308.0
DDNRITLrpmsghkDCTNEYINACFIKDY--SDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS---DTKDYGPFSVTLN
| .|. |       | .. |||| ... |    . ..|||||| ..|. ||||..|... ..|||.|. .| |..|| ||||..   ... ||.|.||| 
dhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtll

DEQVLTDYTVRKMHVKLVDSNdqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYkpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIS
.|.|| |||||..... ....  . ...|..|.|.|||||||......|.| ..... .   .||..||||||||||||| |.|. |.| |||||.|. .
seevlddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfe

IINRMRQQRMKMVQTADQYIFVNDAVLESVTCGN
.....|.||. |||| .||.|. .|.|| . .  
avkklReqRpgmvqtpeqylflyralleylklkl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-242 1.2e-82 272.5 In-house 59-297 (318) alignment
Range on Protein: 1-242
Range on HMM: 59-297/318.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|. |. |....|..  . .|||| .|  |  . .|||.|.|.. |. ||||..|.    .|||.|.. |.||.|...|||..... ||   |.|..|  |
dhtrvkLqmlegee..gsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevel

TDYTVRKMHVKLVDSNDqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
.||..|...|.  ....    .. |||.|||||.|||| ..|.|.. |....   |...||..|||||||||||.|.|.|. |.....|. .|.  ....
sdyvlrefkvtrteeee..srqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkq

MRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFN
.|.||  |||| |||.|. |..|| ...|.|.||... |   .
lreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrir

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2-241 2e-82 271.8 In-house 62-299 (319) alignment
Range on Protein: 2-241
Range on HMM: 62-299/319.0
DNRITLRPMSGHKDCtnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLT
  |..| .. | ..   .|||| ||  | .. ..||||.|.. |. ||||..|.|.  |.||.|.. |..|||...|||. . ..|| . |||..|. | 
rtrvvlseldgvegs..dyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeele

DYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
|| .||....   |..    .......|.||||.|||.|||.|.. .||..  . ...||. |||||||||||||...|. |.. ..|| .|. |...|.
dyiirklklnk.kssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrl

RQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVF
| ||  |||. .||.|. .|.|| |..|.|... .. |  .
RtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl

0040438 (Phosphotyrosine protein) phosphatases II 1-236 2.3e-82 272.1 In-house 56-287 (317) alignment
Range on Protein: 1-236
Range on HMM: 56-287/317.0
DDNRITLRPMSGHKDctNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|..|. | |..|. |  . |||| ... ..   ..|||||| ..|. ||||..|...  .|||.|.  | |..||.||||. .|. ||.|.||| .|..|
dhsRVkLsplggdld..sdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeel

TDYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
 ..|.|...|.    .|......|..|.|.|||||||.. ...|.| ..... ... .||.|||||||||||||| |... |.| |||||.|. ......
agitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkel

RQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRN
|.||...||| .||.|. ||.|| .....| ..  .
reqRpgavqtpeqyrflydalleylkrkltlepase

subfamily_PTPRB_pd Subfamily PTPRB 1-226 2.6e-81 267.9 In-house 64-286 (293) alignment
Range on Protein: 1-226
Range on HMM: 64-286/293.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS-DTKDYGPFSVTLNDEQV
| .|. | ......  ...|||| .|..|. . ..||||||. .|. ||||..|...  ||||.|...|.|||||..|||.  ..  ||  .|||. |..
dhsrvkLaalkdes..gsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeee

LTDYTVRKMHVKLvdsnDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
|.|...|.....     ..    ..|||||||||||||| ....|.| |.....   . .|.|..|||||||||||||.|.|. ||. |.|  .||..|.
ledwvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgiv

NRMRQQRMKMVQTADQYIFVNDAVLESVT
 ..|..|. .||| .||||....||. ..
aelReeRnllvqtekqYifihqcvldllr

0046845 (Phosphotyrosine protein) phosphatases II 1-231 2e-80 265.5 In-house 41-280 (284) alignment
Range on Protein: 1-231
Range on HMM: 41-280/284.0
DDNRITLRPMSGHkDCTNEYINACFIKDY-----SDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD-TKDYGPFSVTL
|..|. |....|. . ...|||| ... |       . ..||||||...|. ||||..|... ..|||.|. .| |..|| ||||... .. ||.|.|||
dhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtl

NDEQVLTDYTVRKMHVKLVDSnDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---
 .|.|  |||||.. .. ..  .......|..|.|||||||||......|.| | ... ..  |..||..||||||||||||| |.|. |.| ||||   
lseevkddytvrtleltnlgy.tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglll

GIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQ
|.|. ....|.|.||. |||| .||.|| .|.|| . ...| 
gvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl

0036941 (Phosphotyrosine protein) phosphatases II 1-231 7.3e-80 263.7 In-house 52-283 (297) alignment
Range on Protein: 1-231
Range on HMM: 52-283/297.0
DDNRITLrpmsghKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDEQ
|..|. |      .|  . ||||.... |. ....|||||| ..|. ||||..|... ..|||.|...| |..||.||||.   ... ||.|.||| ...
dhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsve

V--LTDYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE---KEGGI
|  |.|||.|...|. .  ........|..|.|.||||||||...|.|.| ..... .|  | .||.||||||||||.||| |.|. ||| |   ||||.
vvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggv

DIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQ
|| .... .|.||. .||| .||.|. .|.|| . ...| 
dileavkklReqRpgavqtleqyrflyeallellkkkltk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-232 4e-78 257.7 In-house 70-297 (298) alignment
Range on Protein: 2-232
Range on HMM: 70-297/298.0
DNRITLRPMSGHKDCtnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLT
  |. |. ... ...  .|||| |.. |...  .||||.|. .|..||||....|    |||.||. | .|.|...||||. .. || ..|.|  ... .
ssRvvLekedadees..dYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefa

DYTVRKMHVKLVDSNdqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKG--PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
|..|||..|.  ...     .. | |||||||.||||.|||.|.. |...  ..   |  |..|.|||||||.|||.|||  |....||  .|.  ....
dlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkv

MRQQRMKMVQTADQYIFVNDAVLESVTCGNTQV
.|..|...||| .||.|. .|||| ....|...
lRkkrpgavqteeqYvfiyeavlealdsfndei

Y_phosphatase Protein-tyrosine phosphatase 1-223 6.3e-78 256.8 Pfam-A 14-235 (235) alignment
Range on Protein: 1-223
Range on HMM: 14-235/235.0
DDNRITLrpmsgH-----KDctneYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWP--DSDTKDYGPFSVT
|..|. |     .     .|    |||| ..| |... ..||||||..||. ||||..|||.  .|||.|.. |.|..||.||||  ..... || ..|.
dktrvkl.....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikve

LN-DEQ-VLTDYTVRKMHVKLVDSNDQPPLMiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI
|  .|.   ..||.||...|  ......  . .|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.|.|.|. .
lkekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeev

DIISIINRMRQQRMKMVQTADQYIFVNDAVLE
|. .|....|.||..|||...||||. .|.||
dvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 1-223 6.3e-78 256.8 In-house 14-235 (235) alignment
Range on Protein: 1-223
Range on HMM: 14-235/235.0
DDNRITLrpmsgH-----KDctneYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWP--DSDTKDYGPFSVT
|..|. |     .     .|    |||| ..| |... ..||||||..||. ||||..|||.  .|||.|.. |.|..||.||||  ..... || ..|.
dktrvkl.....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikve

LN-DEQ-VLTDYTVRKMHVKLVDSNDQPPLMiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI
|  .|.   ..||.||...|  ......  . .|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.|.|.|. .
lkekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeev

DIISIINRMRQQRMKMVQTADQYIFVNDAVLE
|. .|....|.||..|||...||||. .|.||
dvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_PTPRK_pd Subfamily PTPRK 2-246 6.4e-78 256.7 In-house 57-298 (314) alignment
Range on Protein: 2-246
Range on HMM: 57-298/314.0
DNRITLRPMSGhkDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKdYGPFSVTLNDEQVLT
  |..| .. |  |  ..|||| .|  |    ..|.||||. .|. |||||...|.   |||.|...|.|.||| .|||.  .. ||.. |.| . ..|.
rsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetella

DYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMR
.. || . |. .  . .   .. |..|..||||.|| .||..|.. ||.|.  ....|...|||||| ||||||.|||. |. .|.|| .|.  ..  .|
elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlr

QQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSN
.... ||.| .||.|. |..||.. ||.| .   . . ..  ...
srkvnmveteeqykfiydvileaclcgetaipvsefkalylesir

0047943 (Phosphotyrosine protein) phosphatases II 1-223 1.2e-77 256.4 In-house 51-270 (273) alignment
Range on Protein: 1-223
Range on HMM: 51-270/273.0
DDNRITLrpmsghKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD---TKDYGPFSVTLNDE
|..|. |      .| .. |||| ... |  . ..|||||| ..|. ||||..|... ..|||.|...| |..|| ||||..    .. ||.|.||| .|
dhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllse

QVLTDYTVRKMHVKLVDSNDqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP--TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIIS
..  |||||.. .. .....  ....|..|.|.|||||||.. .|.|.| . ... ..    .||..||||||||||||| |.|. |.| |||||.|. .
etkddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvle

IINRMRQQRMKMVQTADQYIFVNDAVLE
.....|.||. |||| .||.|. .|.||
avkllrsqRpgmvqtpeqyrflyealle

subfamily_PTPRG_pd Subfamily PTPRG 1-238 5.2e-77 254.3 In-house 60-300 (563) alignment
Range on Protein: 1-238
Range on HMM: 60-300/563.0
DDNRITLRPMSGHKDCTnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|  |..|.|..|.|.   .|||| .|. |  . ..||||||. .|. ||||.||...  |||||||. |.|. ||..|||  ....|| ..||| .|.||
drsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevl

TDYTVRKMHVKL--VDSND--QPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISI
. ||||.. .|   .. ..  .  ....|||.|.||||||||...  |.| .. .   | . ||..||||||||||||....|  |.| ..|  ...  .
alytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgf

INRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNAR
. ..| ||  .||| .||||. ||.|| .. ..|.. . . .
lkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 12-223 2.5e-76 251.5 In-house 69-277 (288) alignment
Range on Protein: 12-223
Range on HMM: 69-277/288.0
GHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDT-KDYGPFSVTLNDEQVLTDYTVRKMHV
...  ...|||| .|...  . .|||||||. .|. |||.|.....   |||.|...|.|| ||..||||.|. | || . ||| ... |.|...||. .
leeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklll

KlvdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQT
.     ..  | ||||....|||||||| .. .|.. | .|.  .   ||..|||||||||||||.|.|. ... |.|  ||........|.||. .|||
e....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqt

ADQYIFVNDAVLE
  ||.|. ...|.
lkqYefiyevlls

DSPc_SM00195 1-224 4.9e-76 250.9 In-house 39-261 (263) alignment
Range on Protein: 1-224
Range on HMM: 39-261/263.0
DDNRITLRPMSGHkdCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDEQ
|..|. | .  ..   ...|||| .|| .. . .||||||| .||. ||||..|.|. .||||.|.  |.|| ||..|||..  .....| .||.| ...
dhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklveve

VLT-DYTVRKMHVKLVDSndQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
    ....|.....  .   . .  .|||....|||||||. ..|.|.. | .|.... ..||..|||||||||||||..||. |.. |.|  .|| .|.
kkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeiv

NRMRQQRMKMVQTADQYIFVNDAVLES
...|.||..|||| .||.|. .|.|| 
kelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 1-224 4.9e-76 250.9 In-house 39-261 (263) alignment
Range on Protein: 1-224
Range on HMM: 39-261/263.0
DDNRITLRPMSGHkdCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDEQ
|..|. | .  ..   ...|||| .|| .. . .||||||| .||. ||||..|.|. .||||.|.  |.|| ||..|||..  .....| .||.| ...
dhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklveve

VLT-DYTVRKMHVKLVDSndQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
    ....|.....  .   . .  .|||....|||||||. ..|.|.. | .|.... ..||..|||||||||||||..||. |.. |.|  .|| .|.
kkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeiv

NRMRQQRMKMVQTADQYIFVNDAVLES
...|.||..|||| .||.|. .|.|| 
kelRkqRpgmvqtleqYlfiyeailey

0043336 (Phosphotyrosine protein) phosphatases II 1-223 6.9e-76 250.6 In-house 58-275 (278) alignment
Range on Protein: 1-223
Range on HMM: 58-275/278.0
DDNRITLRPMSGHKDctNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPdSDTKDYGPFSVTLNDEQVL
| .|. | ...|. |  . |||| ... |.   ..|||||| ..|. ||||..|... ..|||.|.  | |.|||.|||| .... ||.|.||| .|..|
dhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehl

TDYTVRKMHVKLvdSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
 |||||...|.     | .....|.||...||||||||  ...|.| ..... ... .||.||||||||||||||.|... |.|.|||||.|. ......
ddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

RQQRMKMVQTADQYIFVNDAVLE
|.||...||| .||.|. .|.||
reqRpgavqtpsqyrflyealle

0039614 (Phosphotyrosine protein) phosphatases II 1-228 7.5e-76 250.7 In-house 69-292 (297) alignment
Range on Protein: 1-228
Range on HMM: 69-292/297.0
DDNRITLRPMSGHkDCTNEYINACFIKDYSD-EYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKvKCQQYWPDSDTkDYGPFSVTLNDEQV
|..|. | |. |. |  . |||| ... |.    ..|||||| ..|. ||||..|... ..|||.|. .| |. ||.||||.. .  ||.|.||| ....
dhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkveh

LTDYTVRKMHVKLvdsnDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
| .||||...|.     .......|....|.|||||||......|.| . ... ..  | .||.|||||||||||||| |... |.| |||||.|. ...
ldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleav

NRMRQQRMKMVQTADQYIFVNDAVLESVTCG
...|.||...||| .||.|. ||.|| . ..
kelreqRpgavqtpsqyrflydallellkrk

subfamily_PTPRA_pd Subfamily PTPRA 1-240 2.2e-75 248.6 In-house 71-310 (330) alignment
Range on Protein: 1-240
Range on HMM: 71-310/330.0
DDNRITLRPMSGHKDctNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
| .|. | ...|...   .|||| ||. | .  ..||.||| . |. ||||.||. .   |||.|.. |  . ||.|||||  .  ||   |...||.||
dfsrvilsvkeGvee..sdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvl

TDYTVRKMHVK-LVDSN-DQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
 ||||||. |. | |.  .... ...|.||||||| |||  .  .|.. ...|.  . . ||. |||||||||||||...|  |.. . |. .|.  ...
vdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvk

RMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIV
|.|.|| .||||  || |.  ..||    |.|..|       
rlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 14-234 2.2e-73 241.9 In-house 73-288 (315) alignment
Range on Protein: 14-234
Range on HMM: 73-288/315.0
KDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSdTKDYGPFSVTLNDEQVLTDYTVRKMHVKLV
.|   .|.|| ||. |. . .|||.|||  ... |||||...|    |||.||..|. | |...||||     ||...||. .|.| |.|||| . |   
ndphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfg

DsNDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQ
| | .    . |.|.||||| |||.|........|..|   . . |...|||||||||||||...|  |.||| |  ||.  .|...||.|.||||.|.|
d.nir...evvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeq

YIFVNDAVLESVTCGNTQVDS
| |. ||.||.. ||.| .  
yqfiydalletfvcgdtsiaq

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2-228 2.5e-73 241.4 In-house 23-245 (250) alignment
Range on Protein: 2-228
Range on HMM: 23-245/250.0
DNRITLRPMSGHKDCtnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVkCQQYWPDSDTKDYGPFSVTLNDEQVLT
  |. | . .| |..  .|||| |.. |...  .||||||...|..||||....|    |||.||. |..|. ..||||   .. ||   |.| .... .
ssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllskeefa

DYTVRKMHVKlvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
|||.||. .     . .   .. |.||..||| ||||.||..|.. .... . .   ..|..|.|||||||.|.|.|||  |....||  .|.  .|...
dytkrklkls..kakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvl

RQQRMKMVQTADQYIFVNDAVLESVTCG
|..|...|.. .||.||  ..|. ... 
rkdrphavesleqyvfvyeiilkaldsv

subfamily_Ptp69D_pd Subfamily Ptp69D 1-239 2.8e-73 241.7 In-house 61-300 (307) alignment
Range on Protein: 1-239
Range on HMM: 61-300/307.0
DDNRITLRPMSGHKDCtnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|..|. |... |..|   .|||| ||| | .. ..|| |.|| .|. ||||.|..    .|||..|. |  . ||..|||. |.. ||   |.| .|.  
DktRvkLkkingkeds..dYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekh

TDYTVRKMHVKLVDSND---QPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
.||. |...|  .. .    .    ..|||.|.|.|  ||| |...|.. ..... ||  ..|..|||||||||.|.|.|.|. ||| ..|  .||. ..
sdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetv

NRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARI
  .|.||  .||  .||.|.  |.|.  . |.|..| ..   
kdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

0045450 (Phosphotyrosine protein) phosphatases II 1-223 5.4e-73 241.7 In-house 68-302 (307) alignment
Range on Protein: 1-223
Range on HMM: 68-302/307.0
DDNRITLRPMSGHkDCTNEYINACFI--------KDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD-TKDYGPFS
|..|. | ...|. . .. |||| ..        . |    ..|||||| ..|. ||||..|...  .|||.|. .| |..|| |||||.. .. ||.| 
dhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnft

VTLNDEQVLTDYTVRKMHVKLVdSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG
||| .|..| .||||...|.   . .......|..|.|.|||||||..  ..|.| ..... .   | .||.||||||||||||||.|... |.| ||||
vtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekeg

G---IDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
    .|. ......|.||...||. .||.|. .|.||
tlldvdlleavkllreqRpgavqnpeqyrflyealle

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1-230 3.6e-72 237.6 In-house 53-298 (301) alignment
Range on Protein: 1-230
Range on HMM: 53-298/301.0
DDNRITLRPMSGHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD--TKDYGPFSVTLNDEQ
|||||.|.|..  . |..||||| .|..||.. ..||.|||. .||||||||||||.|  |||.||  |. | ||.||||.|.  ....|||.|||..||
ddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneq

VLTDYTVRKMHVKLVDSND-------------QPPLMITQYHFTSWPDHGV-PEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
|. |...|.. ||. |. .             . .  ..|.. |.||..|| .|..| .   .  |. . |. .||..||||..|.|.|.......|| |
vyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQ

AEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNT
.  || .|.. .....|......|.| .||... |.. . ... .|
ckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst

0040439 (Phosphotyrosine protein) phosphatases II 2-223 1.5e-71 236.3 In-house 25-244 (249) alignment
Range on Protein: 2-223
Range on HMM: 25-244/249.0
DNRITLRPMSGhkDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLT
 .|. | ...|     . |||| .|. |    ..|||||| ..|. ||||..|...  .|||.|.  | |..||.||||..... || |.||| ...|. 
hsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkd

DYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
|||||..... .   |...........|.|||||||..  ..|.| ..... ..  |..||.|||||||||||||| |... |.| |||.|.|. .... 
dytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkl

MRQQRMKMVQTADQYIFVNDAVLE
.|.||...||. .||.|. .|.||
lrsqRpgavqnpeqyrflyealle

0045098 (Phosphotyrosine protein) phosphatases II 3-227 3.7e-71 235.1 In-house 48-274 (278) alignment
Range on Protein: 3-227
Range on HMM: 48-274/278.0
NRITlrpmsghkdctnEYINACFIKDYsdEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLTD
.|.             .|||| .|. |    ..||||||  ||. ||||..|... ..|||.|...| |..|| ||||..... ||.|.||| .|.|| |
srVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevldd

YTVRKMHVKLVD--SNDQPPLMITQYHFTSWPDHGVPEYA--TSILQFHRRIKNEYK-------------PTKGPMLVHCSAGVGRTGTFMAIDMGLQQA
||.|...|  .    .| ... .|..|...|||||||..   .|.|.. ..|.. .|             . .||.|||||||||||||. |... |.. 
ytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell

ekEGGIDIISIINRMRQQRMK-MVQTADQYIFVNDAVLESVTC
  |||.|. .... .|.||.  .||. .||.|. ...|| . .
..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

0042113 (Phosphotyrosine protein) phosphatases II 1-223 5e-71 234.3 In-house 22-241 (245) alignment
Range on Protein: 1-223
Range on HMM: 22-241/245.0
DDNRITLRPMSGHKDCTneYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
|..|. | |..|. |..  ||||.... |    ..|||||| ..|. ||||..|...  .|||.|.  | |.|||.||||..... || |.||| .|..|
dhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehl

TDYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINR
 |||||...|. .   | .......||...|||||||..  ..|.|...... .. . .||.||||||||||||||.|... |.|.|||.|... ... .
ddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavke

MRQQRMKMVQTADQYIFVNDAVLE
.|.||...||| .||.|. .|.||
lrsqRpgavqtpsqyrflyealle

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-225 1.3e-70 232.7 In-house 54-276 (281) alignment
Range on Protein: 1-225
Range on HMM: 54-276/281.0
DDNRITLRPMSghKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD-TKDYGPFSVTLNDEQV
|  |... | .  .. ...|||| |.. |..| .|||||||| ..||.||...|...  .|||.|. ||.||.|| .|||| . .  || . |. . |. 
Datrvkvtpne..enkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeee

LTDYTVRKMHVklvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK-NEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISII
 . |  ||...   . .. ..  ..| ..|.|||||||. .. .|.|.. ..  . | || |...|||||||||||..|.|  ....|.|   .|.  ..
katyierkfkl...eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavv

NRMRQQRMKMVQTADQYIFVNDAVLESV
. .|..|. ||||  || ||  |||. .
aelrkernlmvqtvvqyefvykavldal

subfamily_PTPN6_pd Subfamily PTPN6 1-225 6.9e-70 230.5 In-house 67-297 (306) alignment
Range on Protein: 1-225
Range on HMM: 67-297/306.0
DDNRITLRpmsGHKDCTNEYINACFIKD--YSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD-TKDYGPFSVTLNDE
|..|..|.    ..   ..|||| .||.   . . .|||||| ...|. ||||..|||   .|||.|. .| || || .||||.  ...||  |||  .|
Dhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse

QVLTDYTVRKMHVKLVDSNdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK----GPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---G
. |.||..|...|. .... .    . ||||.||||||||.    .|.| . ...... ..    ||..||||||.||||||. ||. |.. ||.|    
ksladYilRelsvskkkkk.keerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldad

IDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
||| .... .|.||  .|||..|| ||  |. . .
idiqklvksvreqrsglvqteqqykfvykaikkyi

subfamily_PTPN12_pd Subfamily PTPN12 1-226 1e-69 229.7 In-house 53-278 (290) alignment
Range on Protein: 1-226
Range on HMM: 53-278/290.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTK--DYGPFSVTLNDEQ
| .|..|. .....   ..|||| |||  ... .|||.|||.. || ||||.||. .  |.||. ...| || ||..|||..  .   .|.|.|||..|.
dksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeek

VLT-DYTVRKMHVKLVdsndQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGL---QQAEKEGGIDII
 .. |...| ..|.      .   ...|.|.|.|||||||. |.|.|.. . ...  .  . |..|||||||||||| .|||.     ..   .  .|. 
avdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvf

SIINRMRQQRMKMVQTADQYIFVNDAVLESVT
... ..|.||  .||| .|| .|  ||.| |.
dlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 3-232 9.1e-68 223.4 In-house 59-284 (315) alignment
Range on Protein: 3-232
Range on HMM: 59-284/315.0
NRITLRPMSghKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPD--SDTKDYGPFSVTLNDEQVL
.|. |  .   ..  ..|||| .|| . |.  |||.|||  ... ||||...||..  |||.|.  |. |.||.|||||  .|. ..| ..|.| . .  
arvklevid..dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslead

TDYTVRKMHVKlvDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRM
|| ..||. ..  .|...    .||..|| |||.||.. ..|.|.. . .| . .. . ..|||||||||||| ...||  ..|....  .|.  ... .
tdgvarklvtr..ksees..rtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknl

RQQRMKMVQTADQYIFVNDAVLESVTCGNTQV
|..|...||| ..| |. ||||| .   || .
rakrpylvqteeeyafiydavledllwrntli

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1-233 1.3e-66 219.4 In-house 46-274 (283) alignment
Range on Protein: 1-233
Range on HMM: 46-274/283.0
DDNRITLRPMSGhkdctnEYINACFIK---DYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDE
| .|. |.. |       .||||.||    .| .. .||..|.|.  | ||||.....|.   |||.|.. |. ..|| ||||   ..|||.| |||..|
dqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrke

QVLTDYTVRKMHVKLVdSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISII
     ...... ..   |  .  |... | .  | . |      |...| . | .  .  |||..||||.|.|||..|.|.   ...|  |  .|. ...
ttsnsfiikelllrvn.ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavv

NRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVD
. ||.||| .||| ||| .| ..|||   ||.||. 
kimreqrmmavqtldqyklvhelvleqalcgdtqia

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 3-223 2.3e-66 218.7 In-house 43-266 (274) alignment
Range on Protein: 3-223
Range on HMM: 43-266/274.0
NRITLRPMSGHKDcTNEYINACFIKDYSDEY-QYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTK----DYGPFSVTLNDE
 |..|.. |....   .|||| .|| |. |   |.|||||...|. ||||.|.||. ..|||.|.. |. . ||..|.||.        || .... .. 
srvllesessede.dssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikveki

QVLTDYTVRKMHVKLVDSNDQpplmITQYHFTSWPDHGVPEYATSILQFHRRIKNE---YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDII
    ||.|||. .| . .. .    .. | .|.|||| .|. |...|.. . ....    .   .|..||||||.|||| |.||.....| ..|. .|..
verndysvrklvlkylerers....vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvl

SIINRMRQQRMKMVQTADQYIFVNDAVLE
.|.  .|..|  ||||..|| ..  |. .
kivcnlrldrGGmvqtseqyelihralcl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3-223 5.1e-66 217.2 In-house 22-238 (239) alignment
Range on Protein: 3-223
Range on HMM: 22-238/239.0
NRITLRPMSghKDCTNEYINACFIKDYSDE-YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKdYGPFSVTLNDEQVLT
.|. |  .|  .|  ..|||| ...||      |||||| |. .  ||||..||||  .|||.| .||  | ||.|||||| .| |  . |||   .|..
srvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.ycnlrvtlrktevfa

DYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMR
|| .| . .  |   ..    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.|.  .||.  .. .|
dyiirtfvmsqvgqtee..ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkair

QQRMKMVQTADQYIFVNDAVLE
..| .||||..||.|.  ||||
edrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3-223 9.9e-66 216.3 In-house 23-239 (239) alignment
Range on Protein: 3-223
Range on HMM: 23-239/239.0
NRITLRPMSghKDCTNEYINACFIKDYSDE-YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKdYGPFSVTLNDEQVLT
.|. |  .|  .|  ..|||| ...||      |||||| |. .  ||||..||||  .|||.| .||  | ||.|||||| .| |  . |||   .|..
srvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.ycnlrvtlrktevfa

DYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMR
|| .| . .  |   ..    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.|.  .||.  .. .|
dyiirtfvmsqvgqtee..ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkair

QQRMKMVQTADQYIFVNDAVLE
..| .||||..||.|.  ||||
edrphmvqtseqyvfihlavle

0037934 (Phosphotyrosine protein) phosphatases II 1-223 1.5e-65 216.4 In-house 23-240 (243) alignment
Range on Protein: 1-223
Range on HMM: 23-240/243.0
DDNRITLrpmsghKDctNEYINACFIKDYSdeyQYIATQGPVSSTLVD----FWRLIWQERPPIIVMITNVIEEGKVKCQQYWPdsDTKDYGPFSVTLND
|..|. |      ..  . |||| .|. .    ..|||||| ..|. |    |||..|...  .|||.|. .| |..|| ||||  ... ||.|.||| .
dhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygdftvtlls

EQVLTDYTVRKMHVKLVDSNDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--------YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAeke
|..| |||||..... .| .|.. .....||...|||||||.  ...|.|.. ...         . ...||.|||||||||||||. |... |..    
eehlddytvrtlllenldlddlt.rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...

gGIDIISIINRMRQQRMK-MVQTADQYIFVNDAVLE
 |.|. ......|.||.  .||| .||.|. .|.||
.gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_PTPN3_pd Subfamily PTPN3 15-223 3.6e-65 214.6 In-house 62-273 (280) alignment
Range on Protein: 15-223
Range on HMM: 62-273/280.0
DCTNEYINACFIKDYSDE----YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS-DTKDYGPFSVTLNDEQVLTDYTVRKMH
. ...|||| ...  ..      .|||||||...|  |||...|...  .|||.|...|.|.||| ||||.. |. .|| |||... |.  . | .|.. 
esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelv

VKLVDSNDQPplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQ
.|  .....   .|.|  ...|||||||. ....|.| .|...  . .. |..||||||.|||| ...... |.  |..  . .. |. .||.||. .||
lkdketkeer..kilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvq

TADQYIFVNDAVLE
||.|| || .|.|.
tasqykfvCeailk

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 15-232 2.6e-64 212.2 In-house 68-283 (515) alignment
Range on Protein: 15-232
Range on HMM: 68-283/515.0
DCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPD--SDTKDYGPFSVTLNDEQVLTDYTVRKMHVkl
.  ..|.|| .|. .  .  |||.|||  ... |||||..||..  |.|.|.  |. |.|| .||||  .|.  .| ..| |   .  |. . ||..|  
nPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..

VDSNDqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTAD
. ..|     .||.||| |||.|||. ..|.|.. . .| .    . |...|||||||||| ...||  . .|..   .|.  ... .||.|...||| .
lkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqe

QYIFVNDAVLESVTCGNTQV
|| |. .|||| .   || .
qyafiygavledllwrntli

subfamily_PTPN9_pd Subfamily PTPN9 1-224 3.5e-64 211.7 In-house 55-289 (297) alignment
Range on Protein: 1-224
Range on HMM: 55-289/297.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWP--DSDTKDYGPFSVTLNDEQ
|. |..|  .....  . .|||| |.  |  .  .||||||.  |  ||||..|...  .|||.| |.|.|..||.||||  . .....| .||.  . .
detrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveve

VLTDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKN-------------EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQA
.  ||.||....| |. ...    .| . |.||||.|||. |.|.|.. . ...             ...|.. |..||||||.||||||...|. |.. 
eeedykvrvleiknvktees..rkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrl

EKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
|..| .|..  ....|.||  ..|| .|| |   |||| 
eevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 3-223 6.8e-64 210.3 In-house 18-237 (237) alignment
Range on Protein: 3-223
Range on HMM: 18-237/237.0
NRITLRPMSGHkdctNEYINACFIKDYSD-EYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDT-KDYGPFSVTLNDEQVL
.|. |.   .      .||||...|..     .|||.|||. |.  |||...|||.  .|||.| .||  ..|| .|||..|  . || ..|.|  .. .
srvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeef

TDYTVRKMHVKlVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
.||||| . .  .  . .   .| ||.||||||.|||......|.| ..| |. .  .  || ..|||||||||| |. ||  |.||...  .||   . 
sdytvrsllls.krltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvy

RMRQQRMKMVQTADQYIFVNDAVLE
 . ..|  ..|| |||.|.....||
sieedrpyiiqtkdqyvfihqtile

subfamily_PTPN13_pd Subfamily PTPN13 18-225 7.8e-63 207.3 In-house 60-269 (273) alignment
Range on Protein: 18-225
Range on HMM: 60-269/273.0
NEYINACFIKDY--SDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKD---YGPFSVTLNDEQVLTDYTVRKMHVKL
  |||| .||     |||.|||.|||.  |  |||...|. .  .|.|.|.  |.|||||..|||.|  |    .. . |.| . | | ...||...|| 
ggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkd

VDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTAD
..|..     ... .|..|||||||  |...||| .....  .  .||..||||||.||.||...||. |.  |..  .|.  |....|.||  .||| |
sesges..revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkd

QYIFVNDAVLESV
|||||  |.|| .
qyifvykailevl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-246 1.2e-61 203.7 In-house 74-312 (319) alignment
Range on Protein: 1-246
Range on HMM: 74-312/319.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITnvieegKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
| |.. |... |      .|||| |.. |  . .|||.|||   || ||||.||. .   ||..|      | || ||||    . .. | | ..  .  
dknvvklerliGee..fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveet

TDYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
 .|.||....   |.. .    |||.||  |||.|||.|.. .... ....     .  . ...|||||||||||.....|. |.. ..|  .|.  ...
aeyvvrdielse.dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvr

RMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSN
 .|||| ..||   || |.  |.||    |...|   .    ....||
dlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsn

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2-233 4.6e-61 201.5 In-house 65-292 (297) alignment
Range on Protein: 2-233
Range on HMM: 65-292/297.0
DNRITLRPMSghKDCTNEYINACFIKDYSDeyQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKvKCQQYWPDSDTKDYGPFSVTLNDEQVLT
 .|..|. .   .|   .|.|| |.| .    ..|.|| |  .|. |||.....|.. .|||...  |. | ||..||.|. .. .|  ||.|.  .  .
ssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsere

DYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPE--YATSILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
 .  |...|.  ..  .   .. ||.|..|||. |..   |.|.|..   ...... ..  |.||||.||||||| ...||  . .|..|  .||  ...
Gfikrelevtkgkakar..rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvk

RMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVD
..||.|...||| .|| ||  |||| . . .|...
klrqerpylvqtkeqykfvyvavleallsedtriq

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-246 4.7e-61 201.8 In-house 38-276 (284) alignment
Range on Protein: 1-246
Range on HMM: 38-276/284.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITnvieegKVKCQQYWPDSDTKDYGPFSVTLNDEQVL
| |.. |... |      .|||| ||. |  . .|||||||   || ||||.||. .   ||..|      | || ||||    . .. | | ..  .  
dknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsvees

TDYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIIN
 .|.||....   |.. .    |.|.||  |||.|||.|.. .... ....     .  . ...|||||||||||.....|. |.. ..|  .|.  ...
eeyvvrdielse.dgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvr

RMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSN
 .|||| ..||   || |.  |.||    |...|   .    ....||
dlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsn

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-234 1.8e-60 199.8 In-house 63-297 (325) alignment
Range on Protein: 3-234
Range on HMM: 63-297/325.0
NRITLRPMsgHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLI--WQerPPiIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDEQ
.|. |  .  ..|   .|||| ...|. .   ..|.| | ..|. |.|||.  |.   . .|...|....|| .| .|||.   ..| .|.. | |   .
srvvletk..kddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..cs.vvvvlneldlgkdrcavywpkemgksktfGglevklrtie

VLTDYTVRKMHVKLVDSNDqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY---KP---TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID
 ..||  |...|| |.  .   . . |... ||.| ||... .... . . .|.     .    . .|.||||||||||||.|...   |..  .|  .|
eisdyvhrvldvkqvkkGe..trsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvd

IISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDS
|   ....|..| .||.|.||||.. .|. | . .|||.|  
ifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpv

subfamily_PTPN23_pd Subfamily PTPN23 1-226 2.5e-58 192.2 In-house 56-281 (288) alignment
Range on Protein: 1-226
Range on HMM: 56-281/288.0
DDNRITLRpmsghkDCTNEYINACFIKDYSDE-YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDE
| ||..||      . ...||||.|.|| |    ..||||.|  ||| |||....... ..|||...  | || |...||| .  .|. .|..||||...
DhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksv

QVLTDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE----YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-D
. .  .  |.....  |..     ...  ..||||..|||.   ..|||   ...      ...| |..|||||||||||.|  .   ... ||. |. |
retethvervlkletldadav..ksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglld

IISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
|| ...|.|.||  |||. .|. |. .|||| . 
iiqvvsrlreqRrfmvqekeqlkfsyeavleaar

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4-224 2.6e-58 192.1 In-house 36-263 (270) alignment
Range on Protein: 4-224
Range on HMM: 36-263/270.0
RITLRPMsgHKDCTNEYINACFIKDYS-DEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTK----DYGPFSVTLNDEQ
|..| ..  ..| . .|||| ... .. .. .|||..||. .|| .|||.||.|. . |||.|.. |.|. ||..||| .  .     .|  .|.   |.
Rvrleel..eedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalsee

VLTDYTVRKMHVKlvDSNDQPPLMitQYHFTSWPDHGVPEYAT------SILQFHRRIKNEYKPT-KG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG
  . | .......  .. ..  |.   .....|||||||. .       ..|.  | ...  | . |. |.|||||||||||||..|.|....  |... 
keegyiltrlrle..ekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkk

IDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
.|...||...|..||..||. .|| |.  ||.| 
vdvlaiieelRkdRmalvqhpeqyeflykavvey

subfamily_PTPRN_pd Subfamily PTPRN 1-225 4.1e-58 191.4 In-house 69-292 (297) alignment
Range on Protein: 1-225
Range on HMM: 69-292/297.0
DDNRITLRPMSGHKdcTNEYINACFIKDYSD-EYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQV
|..|..|.  . ..  ...|||| .| |    .  |||||||..||. |||...|..   .||..|.. |||  .|..||||  .. |. . | |  | .
dhsrvklkeeasae..ksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehi

LT-DYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISII
 . || || ...| .....     .||.|| |||..|||  | |.|.| |..   |.    |..||||.|.||||....||. |..  |    |||.. .
wcddylvrsfylknlqtset..rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatl

NRMRQQRMKMVQTADQYIFVNDAVLESV
. .|.|| ..|.| ||. |.  || | |
ehlrdqrpglvktkdqfefaltavaeev

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 3-241 1.2e-56 187.0 In-house 63-295 (439) alignment
Range on Protein: 3-241
Range on HMM: 63-295/439.0
NRITLRPMSGHKDctNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKvkcqqYWPDSDTKDYGPFSVTLNDEQVLTD
 |.||. . |       |||| .|| | |.  |||||||   |  |||||.....   |||.||..|  |     ||| ..   ||  .|  . .  | .
trvtlqeipgvph..shyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpn

YTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMR
|..| ..|     . .    . |.|...|||. ||  |. .|.| | |.  . |   ||..|||||||||||| .|.|. |.|   |  .||  |.. .|
yvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlr

QQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVF
.|| .|||.  ||.|. .|||| .  |.. |   . .  |
kqrkqmvqalcqyvfiynavledivyGdiavtidefkkef

subfamily_PTPN1_pd Subfamily PTPN1 15-235 1.2e-54 180.0 In-house 53-283 (290) alignment
Range on Protein: 15-235
Range on HMM: 53-283/290.0
DCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDT-----KDYGPFSVTLNDEQVLTDYTVRKMh
.  |.|||| ...    . .|| ||||...|   ||...|...   .||. .|.|....||.||||  .       .   ..|.|  |..   ||||.. 
radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrll.

vKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQR
 .| . . |    |...|.|.||| ||||  .. |.|  ....    .. .|| ..|||||.||.|||. .|  | . ||..    .||   .  .|..|
.elenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyr

MKMVQTADQYIFVNDAVLESVT--CGNTQVDSR
. ..|||||  |   |.|| .    |.. |..|
lGliqtadqlrfsylaileGakvikgdssvqkr

subfamily_PTPN14_pd Subfamily PTPN14 1-225 2.1e-54 179.6 In-house 62-296 (300) alignment
Range on Protein: 1-225
Range on HMM: 62-296/300.0
DDNRITLRPMsghKDCTNEYINACFIKDY--SDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS----DTKDYGPFSVTL
.|||. | |    |. ...||||  ||    . |..||..|||.  |. |||...|..   .|||.|. .|.|| |. .|.|..    .| ..| | || 
ednrvelspt...kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvtt

NDEQVLTDYTVRKMHVKLVDSNDQPPLMITQYhfTSWPDHGVPEYATSILQFHRRIK------NEY---KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQA
.  .  . .. .....| . |...  ... ||  | ||||||||  .. |.. ....      |.    | .| |.||||||||||||  .  |. ..  
kfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatl

EKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
|..  ||| ....|.|.||| .|||  || || .......
ehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

0051429 (Phosphotyrosine protein) phosphatases II 18-224 7e-53 175.3 In-house 4-224 (272) alignment
Range on Protein: 18-224
Range on HMM: 4-224/272.0
NEYINACFIKDYsdeYQ------YIATQGPVSSTLVDFWRLiWQERPPIIVMITNVIEEGKVKCQQYWP------------DSDTKDYGPFSVTLNDEQV
. |||| ... |   ..      .....||   |  ||||| ....   ||..... | |..|| .|||            .  |  || ..|||  |..
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LTDYTVRKMHVKLVDSNDQPpLMITQYHFTSWPDHGVPEYAtsILQFHRRIKNeykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID-------
|.||..|.. ..|. |.... ......|.|.|||||||. |  .|.. . . .     .||.|||||||..||||. |... |.. ..|  .|       
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IISIINRMRQQRMKMVQTADQYIFVNDAVLES
 .  .....|.||...||| .||.|. .|.|| 
yleeaveelraqrpgavqteeqylflyeallel

subfamily_CG7180_pd Subfamily CG7180 1-230 7.2e-52 170.9 In-house 55-295 (296) alignment
Range on Protein: 1-230
Range on HMM: 55-295/296.0
DDNRITLRPMSGHKDCTneYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKvKCQQYWPDSDTKDYGPFSVTLNDEQVL
| ||. |. . |...    |||| ..  .  . .|| |..|. .|. .||||...|    .|..|.. .  | ....|||    ..||.. | .  |. .
DynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqy

TDYTVRKMHVKLV--------DSNDQPPLMITQYHFTSWPD-HGVPEYATSILQFHRRIKN-----EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE
.. . |.....             . .  .......| |.  . ||  ....... ||..      . .|..||..|..| |..|.| ..|||. |...|
anlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelve

KEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNT
||. .|.   . ..|..| ..|.. ..| .. | .|| | |. .
keeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 11-222 1.4e-49 163.4 In-house 58-274 (287) alignment
Range on Protein: 11-222
Range on HMM: 58-274/287.0
SGHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDT-KDYGPFSVTLNDEQVL-TDYTVRKM
| . .   .|||| ..  | |. ..||.|||...|. ||||.....|   ....|  .||.. || .|||. .     | .||.| | ...  .|.|| .
saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvral

HVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-----KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQ
 .  .....    .. |... ||||....  | ....|   .|.           ||..||...|.||.|...|. . ... |. | .|.  .. |.|..
rlidletrea..rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlrey

RMKMVQTADQYIFVNDAVL
|  .||.. |. .. .|. 
raalvqavvqlrllyealv

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 16-232 1.5e-45 150.3 In-house 71-243 (392) alignment
Range on Protein: 16-232
Range on HMM: 71-243/392.0
CTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNViEEGKvkcqqywpdsdtkdygpfsvtlndeqvltdytvrkmhvklvds
  ..|.|| .|. .  |  |||.||| ...| ||||...||..  |.|.|.. .||                                            
pdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtkl.kegd...........................................

NDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYI
. .    ..|.||| |||..||....|.|.| . .| ..     |...||||||||||  ..||  . .|.|   .|.. ..  .|..|  |||| .|| 
kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqya

FVNDAVLESVTCGNTQV
|.  |||| .   || .
fiygavledllwrntli

0036282 (Phosphotyrosine protein) phosphatases II 18-219 1.9e-45 150.0 In-house 2-164 (174) alignment
Range on Protein: 18-219
Range on HMM: 2-164/174.0
NEYINACFIKDYSDEYQYIATQGPVSstlvdFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDsdtkdygpfsvtlndeqvltdytvrkmhvklvdSND
. |||| ... .     .||.||| .     ||.......  ..|| .. .| |..|| .|||.                                   .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

QPPLMITQYHFTSWPDHGVPEYATsILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEkEGGIDIISIINRMRQQRMKMVQTADQYIF
 .  .. ||... |||||||. .. .|.| ..... ..   .||.|||||||||||||..|... |.. . |. .|..... ..|.||..|||| .||.|
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

VND
. .
lyy

0041856 (Phosphotyrosine protein) phosphatases II 17-231 9.7e-45 147.7 In-house 18-177 (182) alignment
Range on Protein: 17-231
Range on HMM: 18-177/182.0
TNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITnvieegkvkCQQYWPdsdtkdygpfsvtlndeqvltdytvrkmhvklvdsn
 . |||| ..  .    ..||||||  ||. ||.|......  .||..|         . .|||                                    
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp....................................

DQPPLMITQYHFTSWPDHGVPEyATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekegGIDIISIINRMRQQRMKMVQTADQYIF
.  . ...||....|||||||.   ..|.| .....     .|| |||||||||||||. |... ...     |... .... .|..|..||.| .||.|
ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyff

VNDAVLESVTCGNTQ
. .|.|| . ...|.
lqlallellllkktr

0046846 (Phosphotyrosine protein) phosphatases II 19-222 3e-43 142.9 In-house 13-170 (176) alignment
Range on Protein: 19-222
Range on HMM: 13-170/176.0
EYINACFIKDYsdeyQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDsdTKDYGPfsvtlndeqvltdytvrkmhvklvdsndq
 |||| .|  .     .||||||. .|| ||........  ..|..|. .| |..|| .|||.   ...|                              
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.............................

pplmitQYHFTSWPDHGVPEYaTSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDmglqQAEKEGGIDIISIINRMRQQRM-KMVQTADQYIFV
      ||... |||||||.. . .|.. . |.. .|   || |||||||.|||||. |..      |.| |...  .. ..|.||. ..||| .|| |.
......qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrfl

NDAVL
 ...|
yefel

0049260 (Phosphotyrosine protein) phosphatases II 26-218 1e-42 140.7 In-house 2-143 (152) alignment
Range on Protein: 26-218
Range on HMM: 2-143/152.0
IKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWpdsdtkdygpfsvtlndeqvltdytvrkmhvklvdsndqpplmitQ
|. |   ...|||||| . || ||||....    .|||.|.  | ||.|| ||.                                             |
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................q

YHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRMKMVQTADQYIFVN
|... |||||||. .  .|.... |.  ..  .|| |||||||||||||..|... |       |...  .....|..|...|.. .|..|. 
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 18-223 1.1e-42 140.7 In-house 81-281 (290) alignment
Range on Protein: 18-223
Range on HMM: 81-281/290.0
NEYINACFIKDYSdeYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTK--DYGPFSVTLNDEQVLTDYTVRKMhVKLVDS
 .|. | ..|       .| |||.. .| .|.||.. ||.   |||. ..||.|| ||.||.|. . .   .| ..|.   |.   . ...|. . . | 
GdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikkt.lsvrdk

NDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYI
..    ..  ..  ||||. |.  . ..|.  | ...    . ||. ||||||.||||||.||..|||   .   .|.. ..  .|. |.. ||   ||.
dsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyl

FVNDAVLE
 . ...|.
alveilld

0043147 (Phosphotyrosine protein) phosphatases II 18-217 3.9e-42 139.2 In-house 5-153 (172) alignment
Range on Protein: 18-217
Range on HMM: 5-153/172.0
NEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVieegkvkcqqywpdsdtkdygpfsvtlndeqvltdytvrkmhvklVDSND
. |||| ... |    ..|||||| ..|| ||||.....   .||..|.                                              .   .
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydpe

QPPLMITQYHFTSWPDHGVPeYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRMKMVQTADQYIF
.   .. ||....|||||||  .  .|.| . |..   .  .||.|||||||||||||. |... |       |...  ... .|..|...||. .||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

V
.
l

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 14-223 2.7e-39 129.8 In-house 53-257 (267) alignment
Range on Protein: 14-223
Range on HMM: 53-257/267.0
KDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEgkvKCQQYWPDS--DTKDYGPFSVTLNDEQVLTDYTVRKMHVK
.. ..||||| ... |  . ..|.||.|.. |  ||. .| ... |.||..|.| ..   . ...||    ..| |  ..|  . |.   || .  . .|
rtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelk

LVDSNDQpplMITQYHFTSWPDHGVPE-YATSIlqFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQT
. . . .    .| |..  |      . |   .  |    ||. .    |..|.||.||||.|||. ||  |..| .||  ||   . ..|.||. .|.|
fknesah...nvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdt

ADQYIFVNDAVLE
 ..||.. . . |
keryiyihellae

PTPc_DSPc_SM00012 123-223 1.1e-37 123.7 In-house 2-105 (105) alignment
Range on Protein: 123-223
Range on HMM: 2-105/105.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK--GPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMVQTADQYIFVND
...||.|.||||||||...|||.. | .|....  .  .|..|||||||||||||.|.|. ||| ||| . .||  |....|.||..|||| .||.|. .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle

0049772 (Phosphotyrosine protein) phosphatases II 3-227 1.9e-37 125.1 In-house 60-282 (314) alignment
Range on Protein: 3-227
Range on HMM: 60-282/314.0
NRITLrPMSGHKDctNEYINACFIKDYsdeYQYIATQGPVSSTLVDF----------WRLI--WQERPPIIVM---------------------ITNVIE
||  | |  ....    |||| ... .    ..|||||| . |.|||          ||..  .. .. .|||                     .... .
nrvil.pglpvsg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildg

EGkvkcqQYWPDSDTKDYGpfsvtlndeqvltdytvrkmhvKLVDSNDQPPLMITQYHFTSWPDHGVPeYATSILQFHRRIKNEykPTKGPMLVHCSAGV
 |      ... .| ...                       . ..... .. .. .|. . .||...|     ...| . |..   ...|| ||||.||.
ng.....neptaadlellk......................eelydpelferlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGk

GRTGTFMAIDMGLQQAekegGIDIISIINRMRQQRM-----KMVQTADQYIFVNDAVLESVTC
||||||..... . .     |...  .....|..|.      .... .||.|. .|.|| .  
gRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkf

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1-223 6.1e-37 122.0 In-house 61-285 (305) alignment
Range on Protein: 1-223
Range on HMM: 61-285/305.0
DDNRITLRPMSGHkdctnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDtKDYGPF-----SVTLN
|.||. |..   |     ||| | ..   ..  ..| || |.  |  ||| . .|..   | |. |..| |  ||..|..  | ||   |      ... 
dnnrvklegpwph.....eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd.kdvlefeekgqkisvk

DEQVLT-------DYTVRKmHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRriknEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE
 |   |       . .|..  | ...   .  . .|.||.  ||| |||   ..||..      . .|.|||. ||||||.||||. . ..  |.|    
fessvtlkfrkdakakvte.tvlviegpgekarkvthyhwidwpdrgvpaadlailelle....karpskgpivvhcsagigrtgsvvmleyildqllag

GGID-IISIINRMRQQRMKMVQTADQYIFVNDAVLE
  |.    |....|.|| . .|| .||.|| . .|.
qiiedtdkilqkireqrnnsiqtdaqylfvhqviln

0051082 (Phosphotyrosine protein) phosphatases II 18-221 1e-36 121.1 In-house 3-149 (151) alignment
Range on Protein: 18-221
Range on HMM: 3-149/151.0
NEYINACFIKDYsdeyqYIATQGPVSstlvDFWRLIWQERPPIIVMITNVIEEGkvKCQQYWPDSDtkdygpfsvtlndeqvltdytvrkmhvklvdsnd
. |||. .. ..     .....|| .    ||..|....    ||....  | |  .| .|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

qppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekeggIDIISIINRMRQQRMKMVQTADQYIFV
   . ........|||.|.|..  ..|.|.. . .   . .||.|||||||.|||||..|... |..      ... .... .|..|. .||. .|..|.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

NDAV
  |.
lfal

0044763 (Phosphotyrosine protein) phosphatases II 17-220 5.7e-36 119.2 In-house 17-166 (178) alignment
Range on Protein: 17-220
Range on HMM: 17-166/178.0
TNEYINACFIKDYsdeyQYIATQGPvsstlVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTkdygpfsvtlndeqvltdytvrkmhvklvdsn
. .||||..| ..     |.....|     .|...|....    ||..|. .| |..|| .|||..                                  
rsdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................................

dqpplmiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekegGIDIISIINRMRQQRMkMVQTADQYIF
        ||... .||||||.    .|.|.. |.. ... .|| ||||||||||.||..|... ...     |... ..|...|..|. .|.. .|. .
.......iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrq

VNDA
. . 
Lyef

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 14-225 1.7e-35 117.4 In-house 55-270 (285) alignment
Range on Protein: 14-225
Range on HMM: 55-270/285.0
KDCTNEYINACFIKD-YSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLND--EQVLTDYTVRKM
|.   .|| | ...    |.  ||.||||.  || |||..|.||.   ..|.  ..| |  ||  |.|.   .   .| . .|| .  |. ..   .  .
knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnal

HVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMV
 |   .     || . . .   |||.  || |  ...... .|.  .| . |. |||||||||| ||. ||    .  ..  |... |.  ||  |.. |
tvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqav

QTADQYIFVNDAVLESV
|.  |..|.   ..| .
qshmqflflyvvlmeyf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4-223 1.9e-35 116.9 In-house 53-267 (281) alignment
Range on Protein: 4-223
Range on HMM: 53-267/281.0
RITLRPMSGHKDCTnEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD--TKDYGPFSVTLNDEQVLT
|. |.     |. | .|| | .|.    .  || ||||   |  ||||.||||    |||. ...|  . || .|.|       ..  .||. .|  |  
rvqlkvkmpnknst.dyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnk

DYTVRkmhvKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINRM
         .|  | .    .||.. .  |||  ||| .  .|.  |.|.        | ..||||||||.||.||... ||       . ||  |. ..
slvtt....rlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarst....ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshl

RQ-QRMKMVQTADQYIFVNDAVLE
|   |   ||| .||...   .|.
rvtgraasvqtlqqymliwkvlld

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 16-223 4e-35 116.3 In-house 65-275 (307) alignment
Range on Protein: 16-223
Range on HMM: 65-275/307.0
CTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDT--KDYG--PFSVTLNDEQ---VLTDYT-VRK
 . .|| | ..    .  ..|..|||  .|  .|| .. ||.   ..|. .||| .|.||.||||  .   . .|  | ......     .  |   .  
lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinv

MHVKLVDsnDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQ-AEKEGGIDIISIINRMRQQRMK
  .|..    |    |... .. |||.|||.   . . .   .. .    . |..|||||||||.|| .|| .  ..  . .   |.  ... .|.||  
ttlkvdw..aqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhy

MVQTADQYIFVNDAVLE
 .||  ||...   .||
aiqteaqylylhrvlle

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 15-227 6.7e-34 112.2 In-house 64-273 (288) alignment
Range on Protein: 15-227
Range on HMM: 64-273/288.0
DCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLNDEQVLTDYTVRKMHVKL
| .. ||.|  .     . . | .| |. .|.  .|... ..    |||.....| || | ..|.|    ..  .| .     ....  | .|.   .. 
ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllri

VDSNDQPPlMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTAD
    ...  .. . |.  |.|.||||   | |..  ..|.  |    |..||.|||||||||.. | . |...  .  . | |.....|..|.| .||  
skegeekv.ivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtem

QYIFVNDAVLESVTC
||..|   ||| .  
qylyvhrcvleelll

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 14-222 7.1e-34 111.8 In-house 75-287 (310) alignment
Range on Protein: 14-222
Range on HMM: 75-287/310.0
KDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS-DTKDYGPFSVTLNDEQvLTDYTVRKMHVKL
|   ..|| | ..|       .| .|||.  |..||||.|.|||   |... .| |||. ||  |||    |. ||   ||   |    .. . .. | .
ksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlses.seefeicnlavtf

VDSN----DQPP----LMITQYHFTSWPDHGVPEYATSILqfHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQR
|  |    .||     | ..  ..  ||| |||.     .   .|.  . .  .|| .||||||..|... .|... ......   .|.  ..  ....|
vpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv..pqrllaqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksr

MKMVQTADQYIFVNDAVL
.. .||  ||....   .
aiciqtelqyliidrvri

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 20-217 8.6e-33 108.4 In-house 77-273 (301) alignment
Range on Protein: 20-217
Range on HMM: 77-273/301.0
YINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD--TKDYGPFSVTLNDEQVLTDYTVRKMHVKLVDSND
 | | .|.   .  ..||||||...|  ||| .. |     |||... .|. . ||..| | .   . | | |.......... .  . | .....|| .
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

Q-PPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIF
. ..  .| | ...|.|.|||.  . . ..   .|.    .. |..||||||.||. .|.. ..  .. | .  |..   ....|..| . |||  |  .
kfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw

V
.
m

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 17-222 1.7e-31 104.0 In-house 79-286 (305) alignment
Range on Protein: 17-222
Range on HMM: 79-286/305.0
TNEYINACFIK-DYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLND-----EQVLTDYTVRKMHV
  .|| | ..      | ..|..|||.  |. .|| .. |..   |||. . .| ||.|| |||| .  .     |  . .       .  |  ..   .
psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitll

KLVDSNDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQ-AEKEGGIDIISIINRMRQQRMKMVQ
.|  | ||  . . . ..| ||| |||    . |..   |.     .| |..||||||.||||| .||.  |.. ||.     .  ... .|.||   .|
nltysgdq.kmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiq

TADQYIFVNDAVL
.  ||.|.   .|
ndvqylfihrvml

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 123-232 2.3e-31 103.6 In-house 91-201 (440) alignment
Range on Protein: 123-232
Range on HMM: 91-201/440.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAV
. |||. .|||.|||..|  .|.. . ... . |  .||.|||||||.||||  .|.|  |..|..   |||.|.|| ||..| .|||| .|| ||..||
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

LESVTCGNTQV
||.. ||.| .
legllcgdtli

subfamily_ptpA1_pd Subfamily ptpA1 17-178 2.1e-30 100.8 In-house 74-249 (418) alignment
Range on Protein: 17-178
Range on HMM: 74-249/418.0
TNEYINACFIkDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDygPFSVTLNDEQVLTDYTVRKMHVK-----
 ..|||| .| | .   |.|.||||.  |. ||||..|..|  ||||..   |. ..||..|||.    .   ||.  | ..|.  |.|  . |      
gsdyinanyi.dgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge..qfsiygngnevfgtysvelveviqdper

-LVDSN-----DQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY---KPT---KGPMLVHCSAGVGRTGTFMAI
 ..  |     .     ||||..  |||| .|...  . |. . | |      |.   . |..||||||||||||| . 
eiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfcta

0048076 (Phosphotyrosine protein) phosphatases II 87-221 2.9e-29 97.0 In-house 13-139 (145) alignment
Range on Protein: 87-221
Range on HMM: 13-139/145.0
YGPFSvTLNDEQVLTDYTVRKMhVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDMGLQqae
.|..  | .| . | |. ..   . | .  . .  ...||....|||||||. .  .|.| . |.. .|   ||.|||||||||||||..|... |.   
lgslp.taldlellkdlgittv.lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll...

keGGIDIISIINRMRQQRMKMVQTADQYIFVNDAV
   |... ......|.||...|.. .|..|. ...
..lgvsleealelvrsqrpgavpnpgqlrflyefe

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 39-217 7.8e-29 95.1 In-house 97-280 (302) alignment
Range on Protein: 39-217
Range on HMM: 97-280/302.0
QGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDS--DTKDYGPFSVTLND-EQVLTDYTVRKM------HVKLVDSNDQPPLMITQYHFT
  |  |||  .| || | .  |.| .....|... || .|. |   ..  .| ..|.  . .. | ..| .|        .|    ... .  .   .|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

SWPDHGVPEYATSILQFHRRIkNEYKptkGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFV
.||||| |. | . |.  .   . ||     .|||||||||||||..||  |.|   |.   |..||.  .|| |   ||...| |..
awpdhGapkeaytaldilkfc.esyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 33-217 1.6e-28 94.2 In-house 5-196 (199) alignment
Range on Protein: 33-217
Range on HMM: 5-196/199.0
YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPD--SDTKDYGPFSVTLNDEQVLTDYTVRKMHvkLVDSNDQPP--LMITQYHF
 .||||| |.  |. |||...|.     |||. .   . ..    |||   | |  || .||| .   .  |||.  .   |...   ||    |..| |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitali..ltnnttappstreishyqf

TSWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMKMVQTADQYIFV
||| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  .. . ..| |.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 33-217 1.9e-28 94.0 In-house 4-195 (198) alignment
Range on Protein: 33-217
Range on HMM: 4-195/198.0
YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPD--SDTKDYGPFSVTLNDEQVLTDYTVRKMHvkLVDSNDQPP--LMITQYHF
 .||||| |.  || |||...|.     |||. .   . ..    |||   | |  || .||| .   .  |||.  .   |...   ||    |..| |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitali..ltnnttappstreishyqf

TSWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMKMVQTADQYIFV
||| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  .. . ..| |.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

0048179 (Phosphotyrosine protein) phosphatases II 108-218 2.9e-28 93.8 In-house 32-138 (144) alignment
Range on Protein: 108-218
Range on HMM: 32-138/144.0
MHVKLVDSNDQPPLM--ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekEGGIDIISIINRMRQQRM
. . |... ... |   ..||....|||||||.... .|.| . |.. ..  .||.|||||||||||||..|... .     . |... ......|..|.
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrp

KMVQTADQYIFVN
 .|.. .|..|. 
gavpnpgqlrfLl

subfamily_CG42327_pd Subfamily CG42327 14-153 1.6e-26 87.7 In-house 52-193 (319) alignment
Range on Protein: 14-153
Range on HMM: 52-193/319.0
KDCTNEYINACFIKDYSDE-YQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKD----YGPFSVTLNDEQVLTDYTVRKM
.|  .||..| ... | |   .|||.| .  ..  ||||..|. .  .|| .|.. | |  .| .|.| ..| |    || . ||| . .|   | .  .
dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistl

HVKLVDSNDQPPlmITQYHFtSWPDHGVPEYATSILQFHRRIKNE
 .| || .   .  .| | .  |.. .||   ....    .... 
llkrvdkeesre..lthywy.kwleaevPaeeaaliamllevrss

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 17-226 6.8e-26 85.7 In-house 66-277 (312) alignment
Range on Protein: 17-226
Range on HMM: 66-277/312.0
TNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSdtKDYgpfsVTLNDEQVLTDYTVR----------
 | || | |.|  .   ....||||. .| . ||.|        |.... ..|.|  || .|  |     .    | |.| .| |.|             
enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi..vgf....vdledhrvyteycteieiggkskdk

--KMHVKLV-DSNDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQ
  .  .|.|  .  |    . .| ..||||||.|.   . |..   .|..    | |.. |||||||||||.. |.  .    .    ..  .   .|..
ithrvlkvvvkatgq.esklnhyqwaswpdhgmpdscdtalrllsavkkd....kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkd

RMKMVQTADQYIFVNDAVLESVT
| . |..  ||...  .||| . 
rarsvrvfpqyvyalrcvlefly

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 14-222 3.2e-25 83.8 In-house 42-256 (290) alignment
Range on Protein: 14-222
Range on HMM: 42-256/290.0
KDCTNEYINACFIKdYSDEYQYIATQGPV-------SSTLVDFWRLIWQERPPIIVMITNVIEEGKV----KCQQYWPDSDT--KDYGPFSVTLNDEQVL
|  ...|| | ... ...  . |.|| |         ||. .|| .. ||.   .||. .. |. .      |..| |.|      .. ..|   .    
krfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskeke

TDYTVRKMHVKLvdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAE-KEGGIDIISIINR
 |  .|.. ||    .|. .. .| . . .| .  |.|   ..|.  . .|..    | |..|||  |. |  .. ||..| |    ..| . . .... 
ddvetRelvvkf...ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlka

MRQQRMKMVQTADQYIFVNDAVL
.|.|| .....| .. ||  ...
lrkqralaitsalelafvdagiv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1-147 4.7e-25 83.1 In-house 46-190 (297) alignment
Range on Protein: 1-147
Range on HMM: 46-190/297.0
DDNRITLRPMSGHKDctneYINACFIK--DYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDE-
||.|. |.     .|    |||| ..   |   ...|| .|||.|.|. |||.|....   .|||.... |.|. ||  |||... .     .| ..   
ddtrvkllrviterd....yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvvefls

QVLTDY-TVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFH
..  .. .|    ..|.  ...   ...   | ||||||||     . .|.
stsdefdrviltelqliyrses..rvvrhvqflswpdhGvpsdledlvrfq

subfamily_egg_pd Subfamily egg 16-245 3.8e-23 76.6 In-house 66-293 (307) alignment
Range on Protein: 16-245
Range on HMM: 66-293/307.0
CTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEgkVKCQQYWPDSDT--KDY--GPFSVTLNDEQVLTDYTVRKMHVK
 ....| |  .|      ..| .| |.  |  ||||...||. . |||.|   |    .|. ||| ...    .  | . ..  . .  .|   |  ..|
ylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklk

LVDSNdqpplmITQYHFTSWP-DHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMAIDMGLQQAEKEgGI---DIISIINRMRQQRMKM
|| ..        . .   |  |        | |.  |...|  |    |..|..  || ...|..||.. | .  .   |    .   .  .|..|   
lvGgd......deerflehwqgdvnnssdvysplrvlrklrnlsk....pvvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrls

VQTADQYIFVNDAVL---ESVTCGNTQVDSRNARIVFNRMS
|... .|.||   ||     |     ..|    | . .|  
vesvllylfvyrlvlfffrdvigsakeldvdyerwleerse

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 44-225 2.7e-22 74.1 In-house 39-221 (255) alignment
Range on Protein: 44-225
Range on HMM: 39-221/255.0
STLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSI
 |.  |.. | | ..  .||...  |||..||..|.|    .      |..   .  .|  .| ... .  .. .    .. |... |...  || |  |
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
|.  . ...  |    ...||||.|.||. .|. ...  |      .  . ...| .|... .|..| . ..|  |  |    ||. |
lnilkvvrds.k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 15-218 2.2e-20 67.3 In-house 72-278 (302) alignment
Range on Protein: 15-218
Range on HMM: 72-278/302.0
DCTNEYINACFIKDYSDEYQYIATQGPVSSTL---VDFWRLIWQERPPIIVMITNVIEEGKvKCQQYWP--DSDTKDYGPFSVtlNDEQVLTDYTV-RKM
 . ..|.||  ..  . ... | .| |....     .|||...||.   .|..    |  |   ....|    | |.|| . |  |  .|        . 
aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfv..NnrkVekaeeektry

HVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMV
 . ..  .    .... |..| |... ||.  ... .    . ..  ... ....    |.|| |.|..  . ... .|.    |  |.. .|.|| ..|
viEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRprav

QTADQYIFVN
....||... 
dslkQyvsly

subfamily_hpo-7_pd Subfamily hpo-7 44-229 4.3e-19 63.4 In-house 45-231 (263) alignment
Range on Protein: 44-229
Range on HMM: 45-231/263.0
STLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKDYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSI
 |.  |.. | | ..  .||...  |||..||..|.|    .      |..   .|  |  ..  ..  . .. .    ...| .. |...  || | .|
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGN
|.  .  .|  |    .. ||||.|.||.  |  ...  |      .  . ...| .|... .|..| . ..|  |  |    ||. |   .
lnilkvarns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnf

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 107-222 5.3e-19 63.1 In-house 204-341 (350) alignment
Range on Protein: 107-222
Range on HMM: 204-341/350.0
KMHVKLVDSNdqpPLMITQYHFTSWPDHGVPEYATSILQFHR--------RI-KNEYKPT-KGPMLVHCSAGVGRTGTFMAIDMGLQQ------A-EK--
 . ..|  |.   |... | ..  |.| ..     ||||            . .. ..     |.|||||||||||||....|. |..        ..  
ltaitlaasd...PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesr

-----EGGIDII-SIINRMRQQRMKMVQTADQYIFVNDAVL
         |.|  |.|..|.||..|||. ||.||. .|.|
kldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 13-86 7.1e-19 62.7 In-house 78-157 (350) alignment
Range on Protein: 13-86
Range on HMM: 78-157/350.0
HKDCTNEYINACFIKDY------SDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSDTKD
|   ||.|||| ..|          ...|||||.|. ||. ||...| .   ..|...|. .| .  ||..||.. . .|
hslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydd

subfamily_CG42327_pd Subfamily CG42327 155-219 4.2e-17 56.8 In-house 244-309 (319) alignment
Range on Protein: 155-219
Range on HMM: 244-309/319.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMVQTADQYIFVND
.  .||. |||| ||||||. .| |. ... |.    .||  ..  .|..| . |.| .|| |.  
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 161-228 1.6e-15 51.3 In-house 1-68 (69) alignment
Range on Protein: 161-228
Range on HMM: 1-68/69.0
MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCG
|.||||.| ||||||.|| . . .   |  .||   .. ||. |  ||    .|||. ||. |..  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 163-228 6.5e-15 49.2 In-house 2-67 (69) alignment
Range on Protein: 163-228
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCG
||||.| ||||||.|| . . .   |  .||   .. ||. |  ||   ..|.|. ||. |..  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 155-225 1.4e-14 48.7 In-house 225-295 (297) alignment
Range on Protein: 155-225
Range on HMM: 225-295/297.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
.| . ..||||||||||.|  .  |. |..  |.   |. .|.. .|.|| ..||| .|. .. ||||. .
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 118-223 1.5e-13 44.8 In-house 215-342 (349) alignment
Range on Protein: 118-223
Range on HMM: 215-342/349.0
QPPLMITQYHFTSWPDHGVPEYATSILQFHRrIKNE----------YK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQ---QAEKE--------GGIDIIS
. | .. |  .  |.| ..     ||||    .||.          ..     ..||||||| ||||... .|. |.     ..|           |.||
ekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

-IINRMRQQRMKMVQTADQYIFVNDAVLE
 |.| .|.||. |||   |.|.. .|.|.
iivnelrkqrismvqnlaqfiaiyealLk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 17-83 2.5e-13 44.1 In-house 89-157 (349) alignment
Range on Protein: 17-83
Range on HMM: 89-157/349.0
TNEYINACFIK--DYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD
 ..|||| ..|   .| | .||||| |. ||. ||...|  .. .... ...  |..  ||..|| . .
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 18-225 3.6e-13 43.8 In-house 69-279 (303) alignment
Range on Protein: 18-225
Range on HMM: 69-279/303.0
NEYINACFIkDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPD-SDTKDYGPFSVTLNDEQVLTDYTVRKMHVKLVdSN
  || | .. .   . . | || |.| |  |||..| ...   ....    |  |.  .  .|   |  ..   |. . . . .      ...|  | ||
ssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsv.sn

DQPPLMITQYHFTSWPDHGVPEY-----ATSILQFHRRIKnEYKPTKGPMLVHCsAGVGRTGTFMAIDMG-LQQAEKEGGIDIISIINRMRQQRMKMVQT
 .   ..  .|. .||   .|          | |    ..  | ... .. .   .|.||.|||  ..   |   ...  .|..  .. .|. |.. || 
gdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlr.kysdstptvymsl.sgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqn

ADQYIFVNDAVLESV
  |. .|   . | |
lsqfsvvytllaehv

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 14-136 1.7e-12 41.5 In-house 118-235 (244) alignment
Range on Protein: 14-136
Range on HMM: 118-235/244.0
KDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEgkvkcQQYWPDSDTKDYG--PFSVTLNDEQVLTDYTVRKMHVK
    | |||| |.       .|| || |.. | .|||... .    ..|..  | ||     ..|||||.  ..     .||| | . . .    .. ..
gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleie

lVDSNDQpPLMITQYHFTSWPDHGV
  | |.     .| .  . ||  | 
.sdmnes.hqaltmfqisnwpsdgt

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 26-112 9.2e-12 39.0 In-house 229-313 (440) alignment
Range on Protein: 26-112
Range on HMM: 229-313/440.0
IKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEgkvKCQQYWPD-SDTKDYGPFSVTLNDEQVLTDYTVRKMHVKL
.. ||    .|||| |. ||..|||||. . |   |.|. .. .     |  |||  . .  .|||.|  .  . .    || . .| 
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelky

subfamily_eak_pd Subfamily eak 17-150 4.2e-11 36.8 In-house 77-207 (332) alignment
Range on Protein: 17-150
Range on HMM: 77-207/332.0
TNEYINACFIkDYSD-EYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEGKVKCQQYWPDSD--TKDYGPFSVTLNDEQVLTDYTVRKMHVKLV
 . ||||  . ..|.   .|| |  .  . .  ||... ... | ||.. . .|..  | ..|.||      ..| . |.  .      . .|.. ..  
rlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskG

DSNDQpplmITQYHFTSWPDHGVPEYAtSILQFHRRI
.   .    .  |..  | .  .| |    | ... .
nethr....vlhykvfGwtettlpkye.dflalrkvm

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 17-135 3.4e-10 34.3 In-house 12-125 (130) alignment
Range on Protein: 17-135
Range on HMM: 12-125/130.0
TNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIEEgkvkcQQYWPDSDTKDYGPF--SVTLNDEQVLTDytVRKMHVKLVD
 |.|||| |.       .|. || |.. | .|||... .    ..|..  | ||     ..|||||.  ..      ||| | .      ..  ...  .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkn..ikasnleies

SNDQPPLMITQYHFTSWPDHG
   .    .| .. . ||  |
dlneshqaltmfqisnwpsdg

0038934 (Phosphotyrosine protein) phosphatases II 125-213 1.9e-09 32.9 In-house 81-165 (194) alignment
Range on Protein: 125-213
Range on HMM: 81-165/194.0
QYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMglqqaEKEGGIDIISIINRMRQQRMKMVQTADQ
.|.   .||.|..     .|.| . ..  ..  ..|  .||| ||.|||||. |  .      .  |..    |...|. | ..... |.
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdy

subfamily_PTPDC1_pd Subfamily PTPDC1 126-219 2.4e-08 28.6 In-house 85-170 (182) alignment
Range on Protein: 126-219
Range on HMM: 85-170/182.0
YHFTSWPDHGVPEYaTSILQFHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAekeggIDIISIINRMRQQRMKMVQTADQYIFVND
..  .|.|.||.   ..||.  . ..   .  .| . ||| || ||||  .|  .  ..      ..    |. .|..| | .|| .|  .|..
vynfgwkDygvasl.eriLdivkvvafalq..egkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 11-69 4.7e-08 26.9 In-house 63-121 (347) alignment
Range on Protein: 11-69
Range on HMM: 63-121/347.0
SGHKDCTNEYINACFIKDYSDEYQYIATQGPVSSTLVDFWRLIWQERPPIIVMITNVIE
 .. | .. ||||  ||    . .|| || |. .|. |||...   .   .| | . |.
nsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepik

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 74-222 1.7e-07 25.0 In-house 149-299 (332) alignment
Range on Protein: 74-222
Range on HMM: 149-299/332.0
KCQQYWPDSD-TKDYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMitqyHFTSWPDH-GVPEYAT----S-ILQFHRRIKNEyKPTKGPMLVHCS
 |...||.    ||.  .|.  .|..  |     .. |     . |  ||    ||  | |   .|||      |  ||. |  |.      ||... |.
icrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlm....hfyewadasklpeymldmrasiklqyirsskkt.gvcigpimlvca

AGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVL
.|| .   . .||. . .  .|  . .   .. .. ||.  ..|   |    . ..
tgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlm

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 5-224 2.5e-07 23.6 In-house 85-308 (346) alignment
Range on Protein: 5-224
Range on HMM: 85-308/346.0
ITLRPMSGHKDCTNEYINAC--FIKDYSDEYQYIATQGPV---SSTLVDFWRLIWQERPPIIVMItnvIEEGKVK--CQQYWPDSDT-KDYGpFSVTLND
|||. .| .  |   |..    ..  .  |.. | .| |     | . ||| .|.||.  .. ..   . . |.|      . | .   .|    . .|.
itlkdvsrrmacvpayvhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylm...vpddklkntttslfndenggyqyt.gkmfinn

EQVLTDYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISI
 .       ..  ....   .   ..   .| . |     |  .  |...  ... | .  .  . |    | ||. .|.     ..| .     .|. |
rradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepnicei

INRMRQQRMKMVQTADQYIFVNDAVLES
.  ..|||   |..  ||  .   |.. 
mknikqqrpggvesfaqyasiyaivfdy

PTEN_1 125-175 2.8e-07 25.6 In-house 96-147 (196) alignment
Range on Protein: 125-175
Range on HMM: 96-147/196.0
QYHFTSWPDHGVPEYAtSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTF
.|.  ...|||.|  . ... . ..... ..  | ..  |||| ||.||.|| 
eylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtv

subfamily_eak_pd Subfamily eak 155-232 7.2e-07 22.9 In-house 234-312 (332) alignment
Range on Protein: 155-232
Range on HMM: 234-312/332.0
KPTKGPMlVHCSAGVGRTGTFMAIDMGLQ--QAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQV
 |.  |. . .. |  |.|.|. ||. ..  .. |.    .  .| .....|.. | .| |. |. ..||. .   | ..
ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrl

PTPlike_phytase Inositol hexakisphosphate 124-178 1.2e-06 23.2 Pfam-A 93-144 (149) alignment
Range on Protein: 124-178
Range on HMM: 93-144/149.0
TQYHFTSWPDHGVPEYAtSILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAI
 .|.    .|.  || .  . .| | ||.   |..  ....|.|| ||| |.|.|
vkYvRipitdeqapeee.dvDafvrliksl..prdtalvfnCqaGrgRTTtamvi

PTPlike_phytase Inositol hexakisphosphate 124-178 1.2e-06 23.2 In-house 93-144 (149) alignment
Range on Protein: 124-178
Range on HMM: 93-144/149.0
TQYHFTSWPDHGVPEYAtSILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAI
 .|.    .|.  || .  . .| | ||.   |..  ....|.|| ||| |.|.|
vkYvRipitdeqapeee.dvDafvrliksl..prdtalvfnCqaGrgRTTtamvi

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2-74 2.6e-06 21.1 In-house 48-117 (332) alignment
Range on Protein: 2-74
Range on HMM: 48-117/332.0
DNRITLRPMSGhkdcTNEYINACFIKDYSDEYQYIATQGPVSS-TLVDFWRLIWQERPPIIVMITNVIEEGKVK
 .|. | |  |     ... || ..  || .  || .| |.   |   |||.. . .| .|... .. |. | |
hsrvelapqdg....kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_CDKN3_pd Subfamily CDKN3 111-219 2.7e-06 21.1 In-house 90-190 (202) alignment
Range on Protein: 111-219
Range on HMM: 90-190/202.0
KLVDSNDQPPLMItqyHFTSWPDHGVPEYATsILQFHRRIKNEYKPTKGpMLVHCSAGVGRTGTFMAIDMgLQQAEKeggIDIISIINRMRQQR-MKMVQ
.|.|   |  |..   |    .| .||. |.  |..   ..   |  ..  ||||  |.||.   .|  . |   .    |.    |...|. .  . .|
rlldlyqqagliv...hhypiadglvpdias.clkileelrinlkayrk.tlvhcygglgrsslviacll.lylddt...iepkdaidklrdlkgsraiq

TADQYIFVND
|  || ....
tvkqynylse

subfamily_DSP23_pd Subfamily DSP23 131-219 2.8e-06 22.1 In-house 59-140 (148) alignment
Range on Protein: 131-219
Range on HMM: 59-140/148.0
WPDHGVPeYATSILQFHrRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMglqqaEKEGGIDIISIINRMRQQRMKMVQTADQYIFVND
 .|.  |     . .|  |. .| .  .  . |||  | |||||..|  .      || ..     |  .|..|   |.| .|   | |
iddyhpp.aleqvvefv.rvveeaeekneavsvhcllgrgrtgtmlacyl.....vkerklaaaeaiaevrrlrpgsvetveqeklvrd

PTPc_motif_SM00404 149-177 5.8e-06 21.3 In-house 72-99 (140) alignment
Range on Protein: 149-177
Range on HMM: 72-99/140.0
RIKNEyKPTKGPMLVHCSAGVGRTGTFMA
 |.|  . ..|  |||| ||| |..|...
fiena.ekkggkvlVHCqaGvSRSatlii

Y_phosphatase3 Tyrosine phosphatase family 147-182 9.5e-06 20.7 Pfam-A 113-148 (164) alignment
Range on Protein: 147-182
Range on HMM: 113-148/164.0
HRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGL
 |.. .    ..||.|.||.||  ||| ..|. . |
yrkvlealaeeegpvlfHCtaGKDRTGvvaalllsl

0048567 (Phosphotyrosine protein) phosphatases II 126-178 9.7e-06 20.0 In-house 40-97 (157) alignment
Range on Protein: 126-178
Range on HMM: 40-97/157.0
YHFTSWPDHGvPEYATSILQFHRRIKNEY---KPTKGPMLVHCSAGV---GRTGTFMAI
.... . |.| |   . . .| ..... .   . ....  |||.||    |||.|... 
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc