Gene PTPRD-16 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP069_AA protein Get Run
AqueP069_AA_117-397 phosphatase_domain Get Run
AqueP069_AA_404-678 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 406-686 1.8e-155 511.1 In-house 7-287 (287) alignment 
Range on Protein: 406-686
Range on HMM: 7-287/287.0
FNRMNEPNTKTGQTGYEEQFTVLQQVTQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMI
|... . ....|..|...|||||.|||||.||||||||||||||||..|.|.||||||.|||||||||||.||.||||||||||||||||||||||||.|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkli

DDRNVTAIVMLCHENENNQEVCYQYWPSTPSgMILGEYNIKLLSEETHNGYIERKFEVKQTN-TGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRT
||||||||||||.|.||..||||||||.. | ..||||||.||.||...||||||.|||..| .|..|.|.||||||||||||.|.||||||||||||.|
ddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

QRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFETYSNF
||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||.||. |..|||.|||||||||.|
qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 114-398 1.6e-144 475.1 In-house 1-285 (290) alignment 
Range on Protein: 114-398
Range on HMM: 1-285/290.0
MIPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDCTNEYINACYINDYSNQYQYIATQGPV
.|||||||||||.||||||.||||||.||||||||||||||||||||||||||||||||||||||||.||||||||||||||||..|....|||||||||
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

SNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNdQPPLMITQYHFTSWPDHG-VPEYAT
||||||||.||||||..||.|.||.||||||||||||||||||.||.||..|..|..|..|. ||..||  .|. ... ..|||..|.|...| |....|
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqt

SILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTX
..|......|...|.......||||..|||...|.|..........||.||........|.|....|||..|| .... ||.... 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 411-684 4.7e-133 437.5 In-house 12-290 (290) alignment 
Range on Protein: 411-684
Range on HMM: 12-290/290.0
EPNTKTGQTGYEEQFTVLQQvTQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLK--GEHPD----YINAAFINGYKEKKAFIIAESPMFNTARNFWKM
. ....|..|...||..|.. .... .||....|.|| .||.......|..|..|.  ..|.|    ||||..|.||||||..|....|..||...|||.
anghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

IDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMiLGEYNIKLLSEETHNGYIERKFEVKQTNT-GATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYR
|....||.||||....|.....|.||||.... . .||..||||.|||.|.|||||.|||..|. ||.||||||||||||||||.||||||||||||||.
iwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

TQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFETYS
||||||||||||||||||.|||.|||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 114-398 5.6e-126 414.3 In-house 1-280 (287) alignment 
Range on Protein: 114-398
Range on HMM: 1-280/287.0
MIPVDKFGEFVAKGHAKGNKGFRNQFGMLDS-GESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYINDYSNQYQYIATQGP
.|||.||||||||||||||.||.||| .|.. ...|. ||....|.|| .||...|.|.|..|. |.      .. ..||||..|. |......|....|
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

VSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHG-VPEYA
..||...||.||.... ..|.|...  |. . .| ||||....  .|.....| .|.| ..|..||..||  ...........||..|.|...| |.|..
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevkn.knkagdkqqvkqyqitnWdstgkvtepq

TSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTX
|..|......|...|.......||||..|||...|.|..........||.||........|.|....|||..||.|.||.|||... 
tillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPRD_pd Subfamily PTPRD 115-465 3.8e-116 384.0 In-house 5-357 (564) alignment 
Range on Protein: 115-465
Range on HMM: 5-357/564.0
IPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGeSEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDCtnEYINACYINDYSNQYQYIATQGPVS
|||... |.||| .|...  | ...  ...| ...|...   . ||  ||.|||| || .|. |... |....  .|||| .|. | .. .|||||||..
ipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPla

NTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSI
.|. ||||..|...| .|.|.|.. |.|||||..|||...|..|| . |||..|. |.||..|.. .|  .|...   ...|.||||||||||||.|||.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkksses..reVrqFhFtsWPdhgvpesatsl

LQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTXXXX------ARIVFNR
|.. |....  .|..||..|||||||||||||..||. |.....|. .|| ......|.||  |||| .||||. .|.|| ..           .  ...
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

MNEPNTKTGQTGYEEQFTVLQ-QVTQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPL
..| ...|..||.|  |  |.  . . ..| .    ..||.|||  . |. .. || |
LaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 115-400 9.7e-100 328.6 In-house 4-287 (305) alignment 
Range on Protein: 115-400
Range on HMM: 4-287/305.0
IPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGesEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYINDYSNQYQYIATQGPVS
| .|.. ... . ... .||. .|. .| .   |... || .. ||  ||...|...||.|| |.. . ..   ..||||.|.. |... .||..|||. 
ialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

NTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTK--NYGPFSVTLNDEQVLTDYTVRKMHVKLVDSnDQPPLMITQYHFTSWPDHGVPEYAT
||..||||||..||   |.|.|...|.|| ||.||||.| |.  ..|.|||.|..|.  .||. ||...   |. |.    ..||..|.|||||||..||
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfat

SILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTXXX
|.|.. .|.....|  || |.||||||||||||.|.|.|. |....||. .|.  .....|..||||||| ||| |. ||. | .|   
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
0051299 (Phosphotyrosine protein) phosphatases II 114-394 1.3e-95 315.4 In-house 4-284 (288) alignment 
Range on Protein: 114-394
Range on HMM: 4-284/288.0
MIPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGhkDCTNEYINACYINDYSNQYQYIATQGPV
 |.|... ..| | .|.|..|....| .| |    .|....|   |.  ||. .|. ||..|. |....|  . .. |||| ||. | .. ..|||||| 
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPl

SNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLV--DSNDQPPLMITQYHFTSWPDHGVPEYA
.||. ||||..|......|.|.|...| |..|| ||||......||...||| .|.|| |||||...|. .   . |. ....|..|.|.|||||||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
...|.| |.... .....||..||||||||||||| |.|. |.| |||||.|. ....|.|.||. |||| .||.|| .|.||
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0050432 (Phosphotyrosine protein) phosphatases II 103-396 6.6e-94 310.0 In-house 14-299 (308) alignment 
Range on Protein: 103-396
Range on HMM: 14-299/308.0
LHGDSSSAKVGMIPVDKFGEFVAKghAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLrpmsghkDCTNEYINACYINDY--
....| ....  ..|... ... |  |....... .|  | |    .. .|.|   || .||. .|. || .|. |       | .. |||| |.. |  
frdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyss

SNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDS---DTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNdqPPLMITQY
 .. ..|||||| .||. ||||..|......|.|.|. .| |..|| ||||..   ....||.|.||| .|.|| |||||..... ....  . ...|..
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthf

HFTSWPDHGVPEYATSILQFHRRIKNEYkpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
|.|.|||||||......|.| ..... .   .||..||||||||||||| |.|. |.| |||||.|. ......|.||. |||| .||.|. .|.|| .
hytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
subfamily_PTPRB_pd Subfamily PTPRB 114-397 6.7e-94 309.2 In-house 6-286 (293) alignment 
Range on Protein: 114-397
Range on HMM: 6-286/293.0
MIPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYINDYSNQYQYIATQGPV
 | ..|| |.|.| .|. . .| ... .| . .....|..  .. |.  ||. ||. || .|. | ......  ...|||| ||..|. . ..||||||.
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdes..gsDYinanyipgynsprefiatqGPl

SNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDS-DTKNYGPFSVTLNDEQVLTDYTVRKMHVKLvdsnDQPPLMITQYHFTSWPDHGVPEYAT
 .|. ||||..|..|| ||.|.|...|.|||||..|||.  .. .||  .|||. |..|.|...|.....     ..    ..|||||||||||||| ..
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektk

SILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
..|.| |.....   . .|.|..|||||||||||||.|.|. ||. |.|  .||..|. ..|..|. .||| .||||....||. ..
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 115-417 1.8e-93 308.1 In-house 2-307 (318) alignment 
Range on Protein: 115-417
Range on HMM: 2-307/318.0
IPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYINDYSNQYQYIATQGPVS
|.|... . |.. ...|.  . ... .|.  |.. | .  |.. ||  ||.|||. ||. |. |....|..  . .|||| ||. | .. .|||.|.|..
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegee..gsDyinanyidGyrrkkayiaaqaPlp

NTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDqpPLMITQYHFTSWPDHGVPEYATSI
.|. ||||..|. .| .|.|.|.. |.||.|...|||......||   |.|..|  |.||..|...|.  ....    .. |||.|||||.|||| ..|.
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeee..srqvrqyhytsWpdegvpesgasl

LQFHRRIKNEY-KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTXXXXA------RIVFN
|.. |....   |...||..|||||||||||.|.|.|. |.....|. .|.  .....|.||  |||| |||.|. |..|| ..           |   .
ldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrir

RMNEPNTKTG
...|.....|
elreqdpesg
0040438 (Phosphotyrosine protein) phosphatases II 119-396 4.1e-91 300.8 In-house 4-276 (317) alignment 
Range on Protein: 119-396
Range on HMM: 4-276/317.0
KFGEFVAKGHAKGNKGFRNQFGMLDSGESEhTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYINDYSNQYQYIATQGPVSNTLV
.. ... . ...........| .|.|   . | .|..   || .||. .|. ||..|. | |..|. |  . |||| |.. .. . ..|||||| .||. 
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdld..sdYInAsyvdgpnlkrkfIatqgPlpntve

DFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFH
||||..|.... .|.|.|.  | |..||.||||. .|..||.|.||| .|..| ..|.|...|.    .|......|..|.|.|||||||.. ...|.| 
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfl

RRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
..... ... .||.|||||||||||||| |... |.| |||||.|. ......|.||...||| .||.|. ||.|| .
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 115-399 1.3e-90 298.7 In-house 5-286 (319) alignment 
Range on Protein: 115-399
Range on HMM: 5-286/319.0
IPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGESEhTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDCtnEYINACYINDYSNQYQYIATQGPVS
|.|... | . . ...|.......| .|. .... |..   .  ||  ||. ||. ||  |..| .. | ..   .|||| .|. | .. ..||||.|..
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegs..dyinasfidgyqerekfiatqaPle

NTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHGVPEYATSI
||. ||||..|.|.| |..|.|.. |..|||...|||. . ..|| . |||..|. | || .||....   |..    .......|.||||.|||.|||.
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnk.kssevetRevkhfqyteWpdhdvPekatsl

LQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTXX
|.. .||..  . ...||. |||||||||||||...|. |.. ..|| .|. |...|.| ||  |||. .||.|. .|.|| |.  
ldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
0036941 (Phosphotyrosine protein) phosphatases II 128-396 1.6e-88 292.2 In-house 8-277 (297) alignment 
Range on Protein: 128-396
Range on HMM: 8-277/297.0
HAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLrpmsghKDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQE
..... ... .|  |..     . .|.|   |. .||. .|. ||..|. |      .|  . ||||.|.. |. ....|||||| .||. ||||..|..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

KSPIIIMITNVIEEGKVKCQQYWPDS--DTKNYGPFSVTLNDEQV--LTDYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKN
....|.|.|...| |..||.||||.   ....||.|.||| ...|  |.|||.|...|. .  ........|..|.|.||||||||...|.|.| .....
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrk

EYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE---KEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
 .|  | .||.||||||||||.||| |.|. ||| |   ||||.|| .... .|.||. .||| .||.|. .|.|| .
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 122-394 2.7e-88 290.8 In-house 10-277 (288) alignment 
Range on Protein: 122-394
Range on HMM: 10-277/288.0
EFVAKGHAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPmsGHKDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFW
. ||| .|....|| ...  | . |....||.|  . |.  ||. ||. || .|. |.   ...  ...|||| ||... .. .|||||||. .|. |||
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkk..leeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDT-KNYGPFSVTLNDEQVLTDYTVRKMHVKlvdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRR
.|....|.  |.|.|...|.|| ||..||||.|. |||| . ||| ... |.|...||. ..     ..  | ||||....|||||||| .. .|.. | 
elvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellrq

IKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
.|.  .   ||..|||||||||||||.|.|. ... |.|  ||........|.||. .|||  ||.|. ...|.
vkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0046845 (Phosphotyrosine protein) phosphatases II 135-396 9.9e-88 289.5 In-house 2-274 (284) alignment 
Range on Protein: 135-396
Range on HMM: 2-274/284.0
FRNQFGMLDSGESEH--TVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHkDCTNEYINACYINDY-----SNQYQYIATQGPVSNTLVDFWRLIWQE
.. .| .| |    .  ...|.|   |. .||. .|..||..|. |....|. . ...|||| |.. |      .. ..||||||..||. ||||..|..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KSPIIIMITNVIEEGKVKCQQYWPDSD-TKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSnDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK
....|.|.|. .| |..|| ||||... ...||.|.||| .|.|  |||||.. .. ..  .......|..|.|||||||||......|.| | ... ..
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy.tgesrtvthfhytswpdhgvppspedlleflrlvrelle

--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---GIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
  |..||..||||||||||||| |.|. |.| ||||   |.|. ....|.|.||. |||| .||.|| .|.|| .
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 128-394 4.1e-87 287.4 In-house 7-270 (273) alignment 
Range on Protein: 128-394
Range on HMM: 7-270/273.0
HAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLrpmsghKDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQE
...|..... .| .| |   ..| .|.|   || .||. .|. ||..|. |      .| .. |||| |.. |  . ..|||||| .||. ||||..|..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

KSPIIIMITNVIEEGKVKCQQYWPDSD---TKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
....|.|.|...| |..|| ||||..    ...||.|.||| .|..  |||||.. .. .....  ....|..|.|.|||||||.. .|.|.| . ... 
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllefielvrka

YKP--TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
..    .||..||||||||||||| |.|. |.| |||||.|. ......|.||. |||| .||.|. .|.||
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_PTPRG_pd Subfamily PTPRG 115-398 6e-87 287.1 In-house 1-289 (563) alignment 
Range on Protein: 115-398
Range on HMM: 1-289/563.0
IPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGESE--HTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDCTnEYINACYINDYSNQYQYIATQGP
.||..| . ||. ||.|..|| ..|  | |   .   ...     .||  ||  ||| ||  |..|.|..|.|.   .|||| ||. |  . ..||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

VSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKL--VDSND--QPPLMITQYHFTSWPDHGVP
. .|. ||||.||.... ||.||||. |.|. ||..|||  ....|| ..||| .|.||. ||||.. .|   .. ..  .  ....|||.|.|||||||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

EYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTX
|...  |.| .. .   | . ||..||||||||||||....|  |.| ..|  ...  .. ..| ||  .||| .||||. ||.|| .. 
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPRA_pd Subfamily PTPRA 108-396 3.5e-86 284.1 In-house 7-295 (330) alignment 
Range on Protein: 108-396
Range on HMM: 7-295/330.0
SSAKVGMIPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYINDYSNQYQYI
.. |   .||.|. | . .  |  || ||..|  | .|. . |. .     ||  ||. ||. || .|. | ...|...   .|||| .|. | .. ..|
gnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvee..sdyinasfidGykekdkfi

ATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVK-LVDSN-DQPPLMITQYHFTSWPDH
|.||| ..|. ||||.||. ||  |.|.|.. |  . ||.|||||  .  ||   |...||.|| ||||||. |. | |.  .... ...|.||||||| 
aaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv

GVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
|||  .  .|.. ...|.  . . ||. |||||||||||||...|  |.. . |. .|.  ...|.|.|| .||||  || |.  ..||  
GvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
0043336 (Phosphotyrosine protein) phosphatases II 115-394 9e-86 283.0 In-house 2-275 (278) alignment 
Range on Protein: 115-394
Range on HMM: 2-275/278.0
IPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGESeHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYINDYSNQYQYIATQGPVS
|.| .. ..... ...........|  |.|     | ...|   || .||. .|. || .|. | ...|. |  . |||| |.. |. . ..|||||| .
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlp

NTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPdSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLvdSNDQPPLMITQYHFTSWPDHGVPEYATSI
.|. ||||..|......|.|.|.  | |.|||.|||| .....||.|.||| .|..| |||||...|.     | .....|.||...||||||||  ...
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslsll

LQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
|.| ..... ... .||.||||||||||||||.|... |.|.|||||.|. ......|.||...||| .||.|. .|.||
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 111-395 3.7e-85 281.2 In-house 10-288 (297) alignment 
Range on Protein: 111-395
Range on HMM: 10-288/297.0
KVGMIPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGESEhtVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHkDCTNEYINACYINDYSN-QYQYIAT
.. .||.. .  .. . .|... .....| .| |   .   ...|   || .||. .|. ||..|. | |. |. |  . |||| |.. |.  . ..|||
esipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIat

QGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKvKCQQYWPDSDTkNYGPFSVTLNDEQVLTDYTVRKMHVKLvdsnDQPPLMITQYHFTSWPDHGVPE
||| ..|. ||||..|......|.|.|. .| |. ||.||||.. . .||.|.||| ....| .||||...|.     .......|....|.|||||||.
qgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpdhgvpp

YATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
.....|.| . ... ..  | .||.|||||||||||||| |... |.| |||||.|. ......|.||...||| .||.|. ||.|| 
slellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 120-397 9.9e-85 279.4 In-house 14-291 (298) alignment 
Range on Protein: 120-397
Range on HMM: 14-291/298.0
FGEFVAKGHAKGNKGFRNQFGMLDSGES---EHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDCtnEYINACYINDYSNQYQYIATQGPVSNT
. ...|. ..|.  |. ..|  |.|..|   |.. .|. ...||  ||.|.|. .|  |. |. ... ...  .|||| ... |...  .||||.|. .|
lqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadees..dYiNAsflhaykgrnafiatqaPltet

LVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNdqPPLMITQYHFTSWPDHGVPEYATSILQ
..||||....|..  |.|.||. | .|.|...||||. ...|| ..|.|  ... .|..|||..|.  ...     .. | |||||||.||||.|||.|.
vedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvld

FHRRIKNeYKPTKG--PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
. |...  ..   |  |..|.|||||||.|||.|||  |....||  .|.  .....|..|...||| .||.|. .|||| ..
llrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
DSPc_SM00195 135-395 9e-84 276.2 In-house 2-261 (263) alignment 
Range on Protein: 135-395
Range on HMM: 2-261/263.0
FRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHkdCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIM
....|  |.. .|....| .  ..||  ||. ||..||..|. | .  ..   ...|||| ||. .... .||||||| ..|. ||||..|.||..||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

ITNVIEEGKVKCQQYWPDS--DTKNYGPFSVTLNDEQVLT-DYTVRKMHVKLVDSndQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGP
.|.  |.|| ||..|||..  .....| .||.| ...    ....|.....  .   . .  .|||....|||||||. ..|.|.. | .|.... ..||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
..|||||||||||||..||. |.. |.|  .|| .|....|.||..|||| .||.|. .|.|| 
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 135-395 9e-84 276.2 In-house 2-261 (263) alignment 
Range on Protein: 135-395
Range on HMM: 2-261/263.0
FRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHkdCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIM
....|  |.. .|....| .  ..||  ||. ||..||..|. | .  ..   ...|||| ||. .... .||||||| ..|. ||||..|.||..||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

ITNVIEEGKVKCQQYWPDS--DTKNYGPFSVTLNDEQVLT-DYTVRKMHVKLVDSndQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGP
.|.  |.|| ||..|||..  .....| .||.| ...    ....|.....  .   . .  .|||....|||||||. ..|.|.. | .|.... ..||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
..|||||||||||||..||. |.. |.|  .|| .|....|.||..|||| .||.|. .|.|| 
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0045450 (Phosphotyrosine protein) phosphatases II 114-394 1.7e-83 276.2 In-house 8-302 (307) alignment 
Range on Protein: 114-394
Range on HMM: 8-302/307.0
MIPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGES--EHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHkDCTNEYINACYI--------NDYSNQ
.|.. |.  .|.. ..... |.. .| .| | .    .. ...|   || .||. .|. ||..|. | ...|. . .. |||| |.        . | ..
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlk

YQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSD-TKNYGPFSVTLNDEQVLTDYTVRKMHVKLVdSNDQPPLMITQYHFTSW
 ..|||||| ..|. ||||..|.... .|.|.|. .| |..|| |||||.. ...||.| ||| .|..| .||||...|.   . .......|..|.|.|
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgw

PDHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
||||||..  ..|.| ..... .   | .||.||||||||||||||.|... |.| ||||    .|. ......|.||...||. .||.|. .|.||
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 159-394 2e-82 271.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 159-394
Range on HMM: 1-235/235.0
NKLLNRFANIVVYDDNRITLrpmsgH-----KDctneYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWP--
||  ||. .|..||..|. |     .     .|    |||| |.. |... ..||||||...|. ||||..||||. .|.|.|.. |.|..||.||||  
nkkknRykdilpydktrvkl.....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

DSDTKNYGPFSVTLN-DEQ-VLTDYTVRKMHVKLVDSNDQPPLMiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAI
......|| ..|.|  .|.   ..||.||...|  ......  . .|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.
eeesltygdikvelkekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

DMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
|. |.|.|.|. .|. .|....|.||..|||...||||. .|.||
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 159-394 2e-82 271.5 In-house 1-235 (235) alignment 
Range on Protein: 159-394
Range on HMM: 1-235/235.0
NKLLNRFANIVVYDDNRITLrpmsgH-----KDctneYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWP--
||  ||. .|..||..|. |     .     .|    |||| |.. |... ..||||||...|. ||||..||||. .|.|.|.. |.|..||.||||  
nkkknRykdilpydktrvkl.....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

DSDTKNYGPFSVTLN-DEQ-VLTDYTVRKMHVKLVDSNDQPPLMiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAI
......|| ..|.|  .|.   ..||.||...|  ......  . .|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.
eeesltygdikvelkekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

DMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
|. |.|.|.|. .|. .|....|.||..|||...||||. .|.||
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 131-394 2.7e-82 270.9 In-house 13-291 (301) alignment 
Range on Protein: 131-394
Range on HMM: 13-291/301.0
GNKGFRNQFGMLDSGESEhTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSP
 ...| .|.  |..||.. . ||||...|| |||| ||.|||||||.|.|..  . |..||||| ||..||.. ..||.|||. .|||||||||||||  
hsnkfeeqykelkegedk.sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

IIIMITNVIEEGKVKCQQYWPDSD--TKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSND-------------QPPLMITQYHFTSWPDHGV-PEYATSI
 |.|.||  |. | ||.||||.|.  ....|||.|||..|||. |...|.. ||. |. .             . .  ..|.. |.||..|| .|..| .
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

LQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
   .  |. . |. .||..||||..|.|.|.......|| |.  || .|.. .....|......|.| .||... |.. .
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 115-425 6.2e-81 266.7 In-house 6-314 (315) alignment 
Range on Protein: 115-425
Range on HMM: 6-314/315.0
IPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGEsEHTVTVGLTSSNKLLNRFANIVVYDDNRITLrPMSgHKDCTNEYINACYINDYSNQYQYIATQGPVS
||.|..  .||. .|  ..||....  .  |.  | . |   . ||  ||. ||. ||  |. | |.   .|   .|.|| .|. |. . .|||.|||  
ipldqlityvaqkkastkngfkqdyesipggq.lhpldvakkienkqknryiniiaydksrvql.pll.endphsdyvnanfidGynkkrryiaaqgpnv

NTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSdTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDsNDQpplMITQYHFTSWPDHGVPEYATSI
... |||||...|.   |.|.||..|. | |...||||     ||...||. .|.| |.|||| . |   | | .    . |.|.||||| |||.|....
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgd.nir...evvqlhytswpdmgvpkytipl

LQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTXX---XXARIVFNRMN-
....|..|   . . |...|||||||||||||...|  |.||| |  ||.  .|...||.|.||||.|.|| |. ||.||..         .. ..| . 
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryds

--EPNTKTGQTGYEEQF
   |.  || |  .|||
llapspdtgstllqeqf
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 127-397 1.7e-80 265.2 In-house 9-277 (281) alignment 
Range on Protein: 127-397
Range on HMM: 9-277/281.0
GHAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQ
 ... |.|| ...  | . . ..| |   .  |.| ||. ||| ||  |... | .  .. ...|||| ... |... .|||||||| ..||.||...|.
lsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpne..enkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvwe

EKSPIIIMITNVIEEGKVKCQQYWPDSD-TKNYGPFSVTLNDEQVLTDYTVRKMHVklvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK-NE
.|  .|.|.|. ||.||.|| .|||| . . .|| . |. . |.  . |  ||...   . .. ..  ..| ..|.|||||||. .. .|.|.. ..  .
qkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl...eresgetreveqlaytaWPdhGvPattkellefrkevlklt

YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
 | || |...|||||||||||..|.|  ....|.|   .|.  ... .|..|. ||||  || ||  |||. . 
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Ptp69D_pd Subfamily Ptp69D 114-397 3e-80 264.6 In-house 3-287 (307) alignment 
Range on Protein: 114-397
Range on HMM: 3-287/307.0
MIPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDCtnEYINACYINDYSNQYQYIATQGPV
 |..|.  | . . . . . |. . . .| . |.... .|.    |.| ||. .|. .|..|. |... |..|   .|||| .|. | .. ..|| |.||
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkeds..dYinasfikgykekkkfiaaqdPv

SNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSND---QPPLMITQYHFTSWPDHGVPEY
 .|. ||||.|.. .. .|.|..|. |  . ||..|||. |...||   |.| .|.  .||. |...|  .. .    .    ..|||.|.|.|  ||| 
eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

ATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
|...|.. ..... ||  ..|..|||||||||.|.|.|.|. ||| ..|  .||. ..  .|.||  .||  .||.|.  |.|.  .
argllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPRK_pd Subfamily PTPRK 134-396 2.5e-79 261.4 In-house 23-277 (314) alignment 
Range on Protein: 134-396
Range on HMM: 23-277/314.0
GFRNQFGMLDSGesehtVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGhkDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIII
||....  |  |       .     |.  ||. .|. ||  |..| .. |  |  ..|||| .|. | .  ..|.||||. .|. |||||...|..  |.
gfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasiv

MITNVIEEGKVKCQQYWPDsDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPML
|.|...|.|.||| .|||. ||. ||.. |.| . ..|... || . |. .  . .   .. |..|..||||.|| .||..|.. ||.|.  ....|...
mltelvevgrvkClkyWPe.dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGriv

VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
|||||| ||||||.|||. |. .|.|| .|.  ..  .|.... ||.| .||.|. |..||..
vhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileac
subfamily_PTPN6_pd Subfamily PTPN6 125-394 8.3e-79 259.7 In-house 18-295 (306) alignment 
Range on Protein: 125-394
Range on HMM: 18-295/306.0
AKGHAKGNKGFRNQFGMLDSGESEHTV--TVGLTSSNKLLNRFANIVVYDDNRITLRpmsGHKDCTNEYINACYIND--YSNQYQYIATQGPVSNTLVDF
 ... ....|| ..|  |.  |.....  . |   .||  ||. ||. .|..|..|.    ..   ..|||| ||..   ... .|||||| ...|. ||
keeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdF

WRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDT-KNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNdQPPLMITQYHFTSWPDHGVPEYATSILQFHR
||..|||.| .|.|.|. .| || || .||||. . ..||  |||  .|. |.||..|...|. .... .    . ||||.||||||||.    .|.| .
WrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkk.keerevfqyhfksWPdhgvpkdpgavLdfle

RIKNEYKPTK----GPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---GIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
 ...... ..    ||..||||||.||||||. ||. |.. ||.|    ||| .... .|.||  .|||..|| ||  |. .
dvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 153-397 3.1e-78 257.4 In-house 3-243 (250) alignment 
Range on Protein: 153-397
Range on HMM: 3-243/250.0
VGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDCtnEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVkCQQYWPD
|.   .||  ||.|.|. .|  |. | . .| |..  .|||| ... |...  .||||||...|..||||....|||  |.|.||. |..|. ..|||| 
vakkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

SDTKNYGPFSVTLNDEQVLTDYTVRKMHVKlvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDM
  ...||   |.| .... .|||.||. .     . .   .. |.||..||| ||||.||..|.. .... . .   ..|..|.|||||||.|.|.||| 
ekaekyGdvtvsllskeefadytkrklkls..kakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

GLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
 |....||  .|.  .|...|..|...|.. .||.||  ..|. ..
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
0045098 (Phosphotyrosine protein) phosphatases II 147-394 7e-78 257.1 In-house 21-270 (278) alignment 
Range on Protein: 147-394
Range on HMM: 21-270/278.0
SEHTVTVGLTSSNKLLNRFANIVVYDDNRITlrpmsghkdctnEYINACYINDYsnQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKC
.  ..|..|  .|. .||. .|. || .|.             .|||| ||. |  . ..||||||  .|. ||||..|......|.|.|...| |..||
ipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

QQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVD--SNDQPPLMITQYHFTSWPDHGVPEYA--TSILQFHRRIKNEYK-------------PTK
 ||||......||.|.||| .|.|| |||.|...|  .    .| ... .|..|...|||||||..   .|.|.. ..|.. .|             . .
aqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

GPMLVHCSAGVGRTGTFMAIDMGLQQAekEGGIDIISIINRMRQQRMK-MVQTADQYIFVNDAVLE
||.|||||||||||||. |... |..   |||.|. .... .|.||.  .||. .||.|. ...||
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
0040439 (Phosphotyrosine protein) phosphatases II 150-394 1.5e-77 255.9 In-house 2-244 (249) alignment 
Range on Protein: 150-394
Range on HMM: 2-244/249.0
TVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGhkDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQY
...|.|   || .||. .|. || .|. | ...|     . |||| ||. |  . ..|||||| ..|. ||||..|.... .|.|.|.  | |..||.||
eysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFM
||......|| |.||| ...|. |||||..... .   |...........|.|||||||..  ..|.| ..... ..  |..||.|||||||||||||| 
wplggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

AIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
|... |.| |||.|.|. .... .|.||...||. .||.|. .|.||
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 155-394 5e-77 253.9 In-house 5-241 (245) alignment 
Range on Protein: 155-394
Range on HMM: 5-241/245.0
LTSSNKLLNRFANIVVYDDNRITLRPMSGHKDCTneYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSD
|   || .||. .|. ||..|. | |..|. |..  ||||.|.. |    ..|||||| ..|. ||||..|.... .|.|.|.  | |.|||.||||...
llpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

TKNYGPFSVTLNDEQVLTDYTVRKMHVKLVdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGL
...|| |.||| .|..| |||||...|. .   | .......||...|||||||..  ..|.|...... .. . .||.||||||||||||||.|... |
sltygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

QQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
.|.|||.|... ... ..|.||...||| .||.|. .|.||
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0050432 (Phosphotyrosine protein) phosphatases II 405-684 4.7e-76 251.4 In-house 28-306 (308) alignment 
Range on Protein: 405-684
Range on HMM: 28-306/308.0
VFNRMNEPNTKTGQTGYEEQFTVLQQVTQrPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLkGEHPDYINAAFINGY--KEKKAFIIAESPMFNTARNFW
| . ..  . ... ...||.|  |..|.  . | ..    .||||||.| .|| |. || | .|. ||||| ...||  | ...||.. .|. ||  .||
vldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFw

KMIDDRNVTAIVMLCHENENNQEVCYQYWPST--PSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEE
.|. . ||. ||||. . ||..| |.||||..   . .. | . ..|||||....|. |..|.. ...| .  ||... |||   |  ..|. .|  .|.
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

MYRTQrkrGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFETYS
. ...   ..  ||||||. |.|.. |.|. . ..  ..|| .|||...|  | |.||.|||..||. .....| || ...|. 
vrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 414-682 7.2e-75 247.0 In-house 17-288 (305) alignment 
Range on Protein: 414-682
Range on HMM: 17-288/305.0
TKTGQTGYEEQFTVLQQVtQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEHP--DYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
... ..|.|.|.  |..  . . .|... |...|....... |..| ...  | ...  |||||....|||.||..|.| .|. || ..||..| .  |.
rvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvs

AIVMLCHENENNQEVCYQYWPSTPSG-MILGEYNIKLLSEETHNGYIERKFEVKQ-TNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRG
 ||||..  |.... |.|||| . .  . .||....| ||.| ..|||||... .  .   ...|.|||.|.|   |  . . ..| .|... ..|.|  
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

NTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFET
.....||||..|.|. .|.|    ....|.|.|.|||.|||  | .... ||| .||. .....  .. ...|
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
subfamily_PTPN12_pd Subfamily PTPN12 148-397 2e-74 245.1 In-house 29-278 (290) alignment 
Range on Protein: 148-397
Range on HMM: 29-278/290.0
EHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQ
... ..| ...|.  ||. .|. || .|..|. .....   ..|||| .|.  ... .|||.|||...|| ||||.||. .  |..|. ...| || ||.
vysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe

QYWPDSD--TKNYGPFSVTLNDEQVLT-DYTVRKMHVKLVdsndQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTG
.|||..   . ..|.|.|||..|. .. |...| ..|.      .   ...|.|.|.|||||||. |.|.|.. . ...  .  . |..|||||||||||
rYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtG

TFMAIDMGL---QQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
| .|||.     ..   .  .|. ... ..|.||  .||| .|| .|  ||.| |.
tiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
0047943 (Phosphotyrosine protein) phosphatases II 413-677 5.2e-73 241.2 In-house 6-272 (273) alignment 
Range on Protein: 413-677
Range on HMM: 6-272/273.0
NTKTGQTGYEEQFTVLQQVTQrPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
....| |...|.|  |....  . . .. .  .||||||.| .|| |. || |.... ||||| ...||. |..||... |. ||  .||.|. . ||. 
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLCHENENNQEVCYQYWPSTPS--GMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-G
||||. . |...| |.||||..     .. |.. ..||||||...|. |..|.. ..|| .  ||... |.|   |  .... .|  ||.. .....  .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

NTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
|. .|||||. |.|...|.|. . ..  ..|| .||....|  | |.||.|||..||. . ...| ||
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 115-397 5.4e-73 240.6 In-house 3-278 (315) alignment 
Range on Protein: 115-397
Range on HMM: 3-278/315.0
IPVDKFGEFVAKGHAkgNKGFRNQFGMLDSGESeHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYINDYSNQYQYIATQGPVS
||| .|  || | .      | ..|  |   .  .  .|. .. |   ||. ||. .| .|. |  .   ..  ..|||| ||. . ..  |||.|||  
ipvaqfpafvnknrh..talfseefhdlpdPdi.yrqrvaretinfkknryknilPldsarvklevid..dsPdsdyinasyiksvdddkayiasqgPlk

NTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPD--SDTKNYGPFSVTLNDEQVLTDYTVRKMHVKlvDSNDQppLMITQYHFTSWPDHGVPEYAT
 .. ||||...|||   |.|.|.  |. |.||.|||||  .|. ..| ..|.| . .  || ..||. ..  .|...    .||..|| |||.||.. ..
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtr..ksees..rtvtqfqftewPdkGvdkqts

SILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
|.|.. . .| . .. . ..|||||||||||| ...||  ..|....  .|.  ... .|..|...||| ..| |. ||||| . 
sllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
0051299 (Phosphotyrosine protein) phosphatases II 415-677 1.6e-72 239.7 In-house 19-286 (288) alignment 
Range on Protein: 415-677
Range on HMM: 19-286/288.0
KTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKG----EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
..|.||..|.|  |....    .... .  .|..|||.. .|| |. || |.     |. ||||| .|.||. |..||... |. ||  .||.|. . ||
angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnv

TAIVMLCHENENNQEVCYQYWPStPSGMILGEYNIKLLSEETHNGYIERKFEVKQT----NTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQR
. ||||. . |...| |.||||.  . ...|.. ..|||||....|. |..||. .     .| .. ||... |||   |  ..|. .|  ...... ..
rvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

kRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
  |.  .|||||. |.|...|.|. . ..  ..||..||....|  | |.||.|||..||. .....| ||
.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 422-685 1.7e-72 239.5 In-house 3-282 (284) alignment 
Range on Protein: 422-685
Range on HMM: 3-282/284.0
EEQFTVLQQVTQRPD-EVTHNIASQNKDKNRSKQFLPPDNYRVPLKG-----EHPDYINAAFINGY-----KEKKAFIIAESPMFNTARNFWKMIDDRNV
||.|  |...|  .  .... .. .|..|||.|..|| |. || ||      |. ||||| ...||     . ||.||..  |. ||  .||.|. . ||
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

TAIVMLCHENENNQEVCYQYWPSTPSGMILGEYNIKLLSEETHNGYIERKFEVKQTN-TGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRK-R
. ||||. . ||..| |.||||.. . ...|.. ..|||||....|. |..|.. .. || .  ||....|.|   |  ..|. .|  .... . ...  
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFETYSN
|.  ||||||. |.|...|.|. . ..  ..||   ..||....|  | |.||.|||..||. .....| || .. |. .
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
0036941 (Phosphotyrosine protein) phosphatases II 411-683 2.4e-72 239.1 In-house 5-283 (297) alignment 
Range on Protein: 411-683
Range on HMM: 5-283/297.0
EPNTKTGQTGYEEQFTVLQQVTQrPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
  . ... ......|  |...   . . .. .  .|..|||.| .|| |. || |..|. ||||| ...||. |..||... |. ||  .||.|. . ||
llekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

TAIVMLCHENENNQEVCYQYWPST-PSGMILGEYNIKLLSEET--HNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRK
| ||||. . |.. | |.||||.. .. .  |.. ..|||.|.  ...|. |..||. |..| .  ||....|.|.  |  ..|...|  ||.. . ...
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

R-GNTSIVVHCSDTVSRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFETY
  ... ..||||. |.||..|.|| . ..  .   .|| .|.....|. | |.||.|||..||. . ...| .| ...|.
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
subfamily_PTPN3_pd Subfamily PTPN3 138-395 1.8e-71 235.3 In-house 20-274 (280) alignment 
Range on Protein: 138-395
Range on HMM: 20-274/280.0
QFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYINDYSNQ----YQYIATQGPVSNTLVDFWRLIWQEKSPIII
|| .|   . . ....   . |   ||. .|. ||. |..|.      . ...|||| |.|  ..      .|||||||...|  |||...|..|| .|.
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MITNVIEEGKVKCQQYWPDS-DTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
|.|...|.|.||| ||||.. |. .|| |||... |.  . | .|.. .|  .....   .|.|  ...|||||||. ....|.| .|...  . .. |.
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeer..kilqlqylaWpdhgvPddsadflefvervrklrsgkeePv

LVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
.||||||.|||| ...... |.  |..  . .. |. .||.||. .||||.|| || .|.|. 
vvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 158-394 2.8e-71 234.4 In-house 6-238 (239) alignment 
Range on Protein: 158-394
Range on HMM: 6-238/239.0
SNKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYINDYSNQ-YQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSdTK
 ||  ||.|||| || .|. |  .|  .|  ..|||| |. ||      |||||| |. .  ||||..|||.  .|.|.| .||  | ||.|||||| | 
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.ts

NYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQA
.|  . |||   .|..|| .| . .  |   ..    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||
kycnlrvtlrktevfadyiirtfvmsqvgqtee..ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

EKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
.|.  .||.  .. .|..| .||||..||.|.  ||||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN9_pd Subfamily PTPN9 122-395 3.9e-71 234.5 In-house 5-289 (297) alignment 
Range on Protein: 122-395
Range on HMM: 5-289/297.0
EFVAKGHAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYINDYSNQYQYIATQGPVSNTLVDFW
|.||  ..||..| ....  . . . | |...  . .|   ||..... ||. |..|  .....  . .|||| ... | ..  .||||||. .|  |||
elvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfW

RLIWQEKSPIIIMITNVIEEGKVKCQQYWP--DSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHR
|..|...  .|.|.| |.|.|..||.||||  . .....| .||.  . ..  ||.||....| |. ...    .| . |.||||.|||. |.|.|.. .
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktees..rkvthfqflsWPdyGvPssaaslldvle

RIKN-------------EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
 ...             ...|.. |..||||||.||||||...|. |.. |..| .|..  ....|.||  ..|| .|| |   |||| 
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 158-394 5.1e-71 233.6 In-house 7-239 (239) alignment 
Range on Protein: 158-394
Range on HMM: 7-239/239.0
SNKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYINDYSNQ-YQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSdTK
 ||  ||.|||| || .|. |  .|  .|  ..|||| |. ||      |||||| |. .  ||||..|||.  .|.|.| .||  | ||.|||||| | 
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.ts

NYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQA
.|  . |||   .|..|| .| . .  |   ..    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||
kycnlrvtlrktevfadyiirtfvmsqvgqtee..ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

EKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
.|.  .||.  .. .|..| .||||..||.|.  ||||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 403-683 1.6e-70 232.7 In-house 11-296 (298) alignment 
Range on Protein: 403-683
Range on HMM: 11-296/298.0
RIVFNRMNEPNTKTGQTGYEEQFTVLQQVTQRPDEVTHNIA--SQNKDKNRSKQFLPPDNYRVPLKG----EHPDYINAAFINGYKEKKAFIIAESPMFN
.. ...... . |.. |||...|  |..|... .| ....|  ..||.|||  . .. |  || |.     |. |||||.|...||...|||... |. .
kaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlte

TARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSgMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILL
|  .||.|. ......||||   .| ..  . .|||.. .    || ...|||.|..  .| ||..|.....  ...| | . |.| . |  .| ...| 
tvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvld

VIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFETY
..... ..|.. ||....|.||. | ||  |.|  . ... |.| |.|||||.|  |...||.||| .||  |...|| .||||...
llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
0037934 (Phosphotyrosine protein) phosphatases II 153-394 2.6e-70 232.0 In-house 4-240 (243) alignment 
Range on Protein: 153-394
Range on HMM: 4-240/243.0
VGLTSSNKLLNRFANIVVYDDNRITLrpmsghKDctNEYINACYINDYSNqyqYIATQGPVSNTLVD----FWRLIWQEKSPIIIMITNVIEEGKVKCQQ
..|   |.  ||. .|. ||..|. |      ..  . |||| .|. . .   .|||||| ..|. |    |||..|.... .|.|.|. .| |..|| |
iallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPdsDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--------YKPTKGPMLVHCSAGV
|||  ....||.|.||| .|..| |||||..... .| .|.. .....||...|||||||.  ...|.|.. ...         . ...||.||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddlt.rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTFMAIDMGLQQAekegGIDIISIINRMRQQRMK-MVQTADQYIFVNDAVLE
|||||. |... |..     |.|. ......|.||.  .||| .||.|. .|.||
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 418-683 4.4e-70 231.8 In-house 17-282 (317) alignment 
Range on Protein: 418-683
Range on HMM: 17-282/317.0
QTGYEEQFTVLQQVtqRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEH----PDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
 |. .|.|  |...   .|. .. .  .||||||.. .|| |. || |. .      ||||| ...|...|..||.. .|. ||  .||.|. . .|| |
ftalleefedllsl..kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

VMLCHENENNQEVCYQYWPStPSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSI
|||... |...| |.||||.  . .  |.. ..|||||...|.. |..||. .... .  ||... |.|.  |   .|...|  .|.. . .. .... .
vmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpv

VVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFETY
.||||. |.|...|.|| . .. ...|| .||....|  | |.||.||| .||. . ...| ||  ..|.
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
0045450 (Phosphotyrosine protein) phosphatases II 413-677 2.8e-69 229.5 In-house 21-304 (307) alignment 
Range on Protein: 413-677
Range on HMM: 21-304/307.0
NTKTGQTGYEEQFTVLQQVTQR-PDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKG-----EHPDYINAAFI--------NGYKEKKAFIIAESPMFNTA
..... ||....|  |..|| . ..| ..    .||||||.| .|| |. || |.      |. ||||| ..        .||. |..||.. .|. .| 
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

RNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMILGEYNIKLLSEETHNGYIERKFEVKQT-NTGATQSVTQYQITNWDSTGKLTNPQTILLV
 .||.|. . .||.||||... |...| |.||||.. . .  |.. ..|||||...||. |..||. .  || .  ||... |.|  .|  ......|  
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldf

IEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
|||. . ...  ... ..||||. |.|...|.|| . .   ..||.   .|.....|  | |.||.||. .||. . ...| .|
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 130-396 6.9e-69 226.9 In-house 6-266 (283) alignment 
Range on Protein: 130-396
Range on HMM: 6-266/283.0
KGNKGFRNQFGMLDSGESEHTvtVGLTSSNKLLNRFANIVVYDDNRITLRPMSGhkdctnEYINACYIN---DYSNQYQYIATQGPVSNTLVDFWRLIWQ
..|| ||...  |   . . .  .  .. ||  ||. .||..| .|. |.. |       .||||..|    .| .. .||..|.|. .| ||||.....
nnnklfrevlkrlsvpdldad..iasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfd

EKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVdSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK
||   |.|.|.. |. ..|| ||||   ...||.| |||..|     ...... ..   |  .  |... | .  | . |      |...| . | .  .
ekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn.ssakstlllahyqvidWleygeqaiinslvkfnkvislqte

PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
  |||..||||.|.|||..|.|.   ...|  |  .|. .... ||.||| .||| ||| .| ..|||  
skkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 113-396 8.4e-69 227.2 In-house 3-288 (325) alignment 
Range on Protein: 113-396
Range on HMM: 3-288/325.0
GMIPVDKFGEFVAKGHAKGNKGFRNQFGMLDSGESeHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMsgHKDCTNEYINACYINDYSNQYQYIATQGP
| | | .. |.| | .|. . || ..||.| | ..  . .|     ||  ||| |.| .| .|. |  .  ..|   .|||| |..|. ..  ..|.| |
gsiavvnlvehvekkkaqdqdgfahefgllpsddg.iakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaP

VSNTLVDFWRLI--WQekSPIIiMITNVIEEGKVKCQQYWPDS--DTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDqpPLMITQYHFTSWPDHGVP
 ..|. |.|||.  |.  .... ...|....|| .| .|||.   ..|..|.. | |   . ..||  |...|| |.  .   . . |... ||.| ||.
ltatindlWrlvldWr..csvv.vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGe..trsvkqfqlqswddmGvq

EYATSILQFHRRIKNEY---KP---TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
.. .... . . .|.     .    . .|.||||||||||||.|...   |..  .|  .||   ....|..| .||.|.||||.. .|. | .
krpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPRD_pd Subfamily PTPRD 415-683 1.2e-68 227.2 In-house 19-287 (564) alignment 
Range on Protein: 415-683
Range on HMM: 19-287/564.0
KTGQTGYEEQFTVLQQVTQRPdeVTHNIASQNKDKNRSKQFLPPDNYRVPLK----GEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
.....  ||..  ... .| .  ...  ...|| ||| .. .. |. || |.     |  ||||| ||.||...||.| .  |. .| ..||.|. ..|.
ansdlkfeeeykkieegqqft..weaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqns

TAIVMLCHENENNQEVCYQYWPSTpSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQrKRGN
. |||| . .|.... | .|||.. .    ||. ..| .||. . |. |.|..|....  .. |.|.. |.| ..|  ......| .|... ... ....
stiVmltkleEkgkvkchkYWPek.gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epda

TSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFETY
  ||||||  | |. .|..    ... |.|...|..|..|  | |..  ||| .||. |....| .|....| 
gPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 158-394 5.1e-68 223.8 In-house 2-237 (237) alignment 
Range on Protein: 158-394
Range on HMM: 2-237/237.0
SNKLLNRFANIVVYDDNRITLRPMSGHkdctNEYINACYINDYSN-QYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDT-
 ||. ||..|||.|| .|. |.   .      .||||.|....     .|||.|||. ..  |||...||||  .|.|.| .||  ..|| .|||..|  
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

KNYGPFSVTLNDEQVLTDYTVRKMHVKlVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGL
. || ..|.|  .. ..||||| . .  .  . .   .| ||.||||||.|||......|.| ..| |. .  .  || ..|||||||||| |. ||  |
aaygvltvslkkkeefsdytvrsllls.krltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

QQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
.||...  .||   .  . ..|  ..|| |||.|.....||
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 116-397 6e-68 224.2 In-house 3-277 (515) alignment 
Range on Protein: 116-397
Range on HMM: 3-277/515.0
PVDKFGEFVAKGHAkgNKGFRNQFGMLdSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYINDYSNQYQYIATQGPVSN
|. .|  ||.|        | ..|  |  |   .  ||     |   ||. ||. || .|. |  .    .  ..|.|| ||. . |.  |||.|||   
plaqfPafvnknrh..ttlfseefhdl.pgpniypqtvaqeeinfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnka

TLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPD--SDTKNYGPFSVTLNDEQVLTDYTVRKMHVklVDSNDqpPLMITQYHFTSWPDHGVPEYATS
.. |||||..||.   |.|.|.  |. |.|| .||||  .|. ..| ..| |   .  |. . ||..|  . ..|     .||.||| |||.|||. ..|
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgdd..srtvtqfhfteWPdkGvpkhtss

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
.|.. . .| .    . |...|||||||||| ...||  . .|..   .|.  ... .||.|...||| .|| |. .|||| . 
llklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 160-393 7.2e-68 223.6 In-house 29-265 (274) alignment 
Range on Protein: 160-393
Range on HMM: 29-265/274.0
KLLNRFANIVVYDDNRITLRPMSGHKDcTNEYINACYINDYSNQY-QYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDT---
.  ||. .|.  .  |..|.. |....   .|||| ||  |...   |.|||||..||. ||||.|.||....|.|.|.. |. . ||..|.||.     
qtknryktilPnensrvllesessede.dssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

-KNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQpplmITQYHFTSWPDHGVPEYATSILQFHRRIKNE---YKPTKGPMLVHCSAGVGRTGTFMAIDM
 ..|| .... ..     ||.|||. .| . .. .    .. | .|.|||| .|. |...|.. . ....    .   .|..||||||.|||| |.||..
serygdveikvekiverndysvrklvlkylerers....vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

GLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVL
...| ..|. .|...|.  .|..|  ||||..|| ..  |. 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_PTPN13_pd Subfamily PTPN13 146-396 1.6e-67 222.6 In-house 24-269 (273) alignment 
Range on Protein: 146-396
Range on HMM: 24-269/273.0
ESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGhkdctneYINACYIND--YSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGK
 .  |..|| . .||  ||. |.. ||. |..|   .|       |||| .|.     ..|.|||.|||. .|  |||...|. |. .|.|.|.  |.||
kpldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk

VKCQQYWPDSDTK---NYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGV
|||..|||.|  |    .. . |.| . | | ...||...|| ..|..     ... .|..|||||||  |...||| .....  .  .||..||||||.
vkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesges..revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGi

GRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
||.||...||. |.  |..  .|.  |....|.||  .||| ||||||  |.|| .
GrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 415-685 1.6e-67 222.3 In-house 11-301 (301) alignment 
Range on Protein: 415-685
Range on HMM: 11-301/301.0
KTGQTGYEEQFTVLQQVTQRPDEVTHNiaSQNKDKNRSKQFLPPDNYRVPLKGE------HPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDR
.. ....|||.. |....... .|...  ..||  || |.  . |. |. || .      . .|||| .|.||.|||.||.|..|| .| ..||..| . 
akhsnkfeeqykelkegedksctvgls..eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

NVTAIVMLCHENENNQEVCYQYWPSTP-SGMILGEYNIKLLSEE-----------------THNGYIERKFEVKQTNtgATQSVTQYQITNWDSTGKLTN
 ...|||.. ..|. .. |.||||..  .    |. ...| .|                  . ||||||||.||...  ....|.|.|.|.|   | . .
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvre

PQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFETYSN
|.|.| ||...  .|.| |   .||||||||||| ..|.   ..  || |||.||||| |. | .||| |.| .||  |.... .||   .||.|
prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
DSPc_SM00195 422-677 4.9e-67 221.4 In-house 3-262 (263) alignment 
Range on Protein: 422-677
Range on HMM: 3-262/263.0
EEQFTVLQQVTQRPdEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEH----PDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
.|.|. |.. |.   |.|... ..||.|||.|..|| |. || || |.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

HENENNQEVCYQYWPSTP-SGMILGEYNIKLLSEETHN-GYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRgNTSIVV
 |.||..| |..|||..  . .  |....|| ..|...  .| |..|......  |..|||||..||   |   ... .| ...... ....  .. |||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivV

HCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
|||. |.|...|... . ..|...|  .|.|...|. | |.||.||| .||..| ...| |.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 422-677 4.9e-67 221.4 In-house 3-262 (263) alignment 
Range on Protein: 422-677
Range on HMM: 3-262/263.0
EEQFTVLQQVTQRPdEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEH----PDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
.|.|. |.. |.   |.|... ..||.|||.|..|| |. || || |.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

HENENNQEVCYQYWPSTP-SGMILGEYNIKLLSEETHN-GYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRgNTSIVV
 |.||..| |..|||..  . .  |....|| ..|...  .| |..|......  |..|||||..||   |   ... .| ...... ....  .. |||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivV

HCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
|||. |.|...|... . ..|...|  .|.|...|. | |.||.||| .||..| ...| |.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 156-395 7.1e-67 221.0 In-house 58-290 (319) alignment 
Range on Protein: 156-395
Range on HMM: 58-290/319.0
TSSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITnvieegKVKCQQYWPDSDT
   ||  ||. ||. .| |.. |... |      .|||| ... | .. .|||.|||  ||| ||||.||. ..  |...|      | || ||||    
ldqnkdknriinilafdknvvklerliGee..fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

KNYGPFSVTLNDEQVLTDYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGL
.... | | ..  .   .|.||....   |.. .    |||.||  |||.|||.|.. .... ....     .  . ...|||||||||||.....|. |
ikeerfkvkvdsveetaeyvvrdielse.dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvll

QQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
.. ..|  .|.  ... .|||| ..||   || |.  |.|| 
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
0039614 (Phosphotyrosine protein) phosphatases II 412-681 7.1e-67 221.3 In-house 25-293 (297) alignment 
Range on Protein: 412-681
Range on HMM: 25-293/297.0
PNTKTGQTGYEEQFTVLQQVTQrpDeVTHNIASQNKDKNRSKQFLPPDNYRVPLKG-----EHPDYINAAFINGYKE-KKAFIIAESPMFNTARNFWKMI
 ..... |.....|  |....   |  ..    .||||||.| .|| |. || ||.     .. ||||| ...||.  ...||..  |. .|  .||.|.
lekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

DDRNVTAIVMLCHENENNQeVCYQYWPSTPSgmILGEYNIKLLSEETHNGYIERKFEVKQtnTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQ
 . .||.||||. ..|...  |.||||.. .    |.. ..||..|...||. |..||.   .| .  ||..| |.|   |   .....| ..|.. . .
weqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

RKR-GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFE
..  ... ..||||. |.|...|.|| . .. ...|| .||....|  | |.||.||| .||. .....| .|  . 
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 156-395 2.8e-66 218.9 In-house 22-254 (284) alignment 
Range on Protein: 156-395
Range on HMM: 22-254/284.0
TSSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITnvieegKVKCQQYWPDSDT
   ||  ||. .|. .| |.. |... |      .|||| .|. | .. .|||||||  ||| ||||.||. ..  |...|      | || ||||    
ldqnkdknrighilafdknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

KNYGPFSVTLNDEQVLTDYTVRKMHVKLvDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGTFMAIDMGL
.... | | ..  .   .|.||....   |.. .    |.|.||  |||.|||.|.. .... ....     .  . ...|||||||||||.....|. |
ikeerfkvkvdsveeseeyvvrdielse.dgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvll

QQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
.. ..|  .|.  ... .|||| ..||   || |.  |.|| 
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
0043336 (Phosphotyrosine protein) phosphatases II 415-677 1.4e-65 216.8 In-house 16-277 (278) alignment 
Range on Protein: 415-677
Range on HMM: 16-277/278.0
KTGQTGYEEQFTVLQQVTQrpDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEH----PDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
....|.....|  |....   |. .. .  .||||||.| .|| |. || |. .      ||||| ...||. ...||..  |. .|  .||.|. . .|
lnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

TAIVMLCHENENNQEVCYQYWPstPSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGN
| ||||. . |.... |.||||   . .  |.. ..||.||....|. |..||. . .| .. ||.|. ..|   |  ......|  .... . ..   |
ttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsn

TSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
. ..||||. |.|...|.|. . ..  ..|| .|.....|  | |.||.||| .||. .....| ||
gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 408-685 1.8e-65 216.1 In-house 13-288 (318) alignment 
Range on Protein: 408-685
Range on HMM: 13-288/318.0
RMNEpntkTGQTGYEEQFTVLQQVTQRPDEvTHNIASQNKDKNRSKQFLPPDNYRVPLKG----EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWK
|..|    .|.. ..|..  |..... . . .. . . || |||    |. |. || |.     |  ||||| .|.||..|||.| | .|. .| ..||.
rlre....sGelllseeyerlsrseetvts.lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWr

MIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSgMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYR
|. ..| . |||| .|.|. .. . .||||  | . .|.  ..| .| . . |. |.|.|..|.. ... | ||..|.|  .| .... ..| .. .  .
mvWeqnsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvsk

TQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFETYSN
.|.| |.. ||||||  | |  .|.|  . ... | |...||||. |  | |..  ||| .||..|....| .| |..|. .
aqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 115-398 8.1e-65 213.9 In-house 10-286 (297) alignment 
Range on Protein: 115-398
Range on HMM: 10-286/297.0
IPVDKFGEFVAKGHAkgNKGFRNQFGMLdsGES-EHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSghKDCTNEYINACYINdySNQYQYIATQGPV
||. .|  .| |..    . |...|  |   |.  .. ||     |   .|..||. || .|..|. .   .|   .|.|| ...  .|....|.|| | 
iplsdfatlvqknrh..tdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvk..gnkhrlittqmPm

SNTLVDFWRLIWQEKSPIIIMITNVIEEGKvKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPE--YA
 .|. |||.....|.  .|.|...  |. | ||..||.|. ....|  ||.|.  .  . .  |...|.  ..  .   .. ||.|..|||. |..   |
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakar..rvvkqyqfveWPdkaverkdsa

TSILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTX
.|.|..   ...... ..  |.||||.||||||| ...||  . .|..|  .||  .....||.|...||| .|| ||  |||| .  
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
Y_phosphatase Protein-tyrosine phosphatase 446-674 2.1e-64 212.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 446-674
Range on HMM: 1-234/235.0
NKDKNRSKQFLPPDNYRVPL--KGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWP-STPSGMILGE
||.|||.|..|| |. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....|...| | |||| ..   .  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YNIKLL-SEE-THNGYIERKFEVKQTNTG-ATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKT
....|  .|.  ...|. ||.|.|....  ....|.|...|||   |  ..|. .| .|... ... .  ....|||||. |.|...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVL
|. .||.|..|. | |.||.||...||... ...|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 446-674 2.1e-64 212.5 In-house 1-234 (235) alignment 
Range on Protein: 446-674
Range on HMM: 1-234/235.0
NKDKNRSKQFLPPDNYRVPL--KGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWP-STPSGMILGE
||.|||.|..|| |. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....|...| | |||| ..   .  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YNIKLL-SEE-THNGYIERKFEVKQTNTG-ATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKT
....|  .|.  ...|. ||.|.|....  ....|.|...|||   |  ..|. .| .|... ... .  ....|||||. |.|...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVL
|. .||.|..|. | |.||.||...||... ...|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 418-675 2.4e-64 212.0 In-house 5-264 (283) alignment 
Range on Protein: 418-675
Range on HMM: 5-264/283.0
QTGYEEQFTVLQQVTQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFIN---GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIV
..... .. ||....  . ... . |..|| ||| .. .| |..|| || | .|||||.||     ||..| .||| ||. .| ..||||. |...||||
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLCHENENNQEVCYQYWPSTPSgMILGEYNIKLLSEETHNGYIERKFEVKQT-NTGATQSVTQYQITNWDSTGKLTNPQTiLLVIEEMYRTQRKRGNTSI
|| .  |.... | ||||.  | .  ||. . |  | |.| .| ... ...   . .|  .. ||. .| . |. .   . |. .. .   |..  .. |
mltklqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiins.lvkfnkvislqteskkgPi

VVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLT
||||| .. |.|.|.||...... .|| |.|||.|.|  | |... ||| .||... ..|| 
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
0045098 (Phosphotyrosine protein) phosphatases II 429-678 7.5e-63 207.8 In-house 16-273 (278) alignment 
Range on Protein: 429-678
Range on HMM: 16-273/278.0
QQVTQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPlkgehpDYINAAFINGYkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCY
. ..  |.|.|...   |.|||| |..|| |. ||       ||||| .|.||  .|.||..  |. .|. .||.|. . ..|.||||... |...| |.
llllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

QYWPStPSGMILGEYNIKLLSEETHNGYIERKFEVKQT----NTGATQSVTQYQITNWDSTGKLTNP--QTILLVIEEMYRTQR------------KRGN
||||.  . .. |.. ..|||||... |. |...|  .    ... .  ||......|.  |  ..|  . .| ..|.. . ..              ..
qywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

TSIVVHCSDTVSRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVQQYQVIFQIVLTYLD
. ..||||  |.|.....|| . .  .  ||..|.....|  | |.|| .||. .||. ... .| .| 
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN23_pd Subfamily PTPN23 128-397 9.6e-63 206.7 In-house 10-281 (288) alignment 
Range on Protein: 128-397
Range on HMM: 10-281/288.0
HAKGNKGFRNQFGMLDSGESEHTV--TVGLTSSNKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYINDYSNQ-YQYIATQGPVSNTLVDFWRLI
  .|. .. ..|  |.. . ...   .. .   .   ||. .|. || ||..||      . ...||||....| | .  ..||||.|  .|| |||...
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WQEKSPIIIMITNVIEEGKVKCQQYWPDS--DTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIK
...||..|.|...  | || |...||| .  .|...|..||||.... .  .  |.....  |..     ...  ..||||..|||.   ..|||   ..
yeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadav..ksvshlqltsWpelGvPasPetllqfldeve

NE----YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
.      ...| |..|||||||||||.|  .   ... ||. |. ||| ...|.|.||  |||. .|. |. .|||| . 
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 149-396 1.2e-62 206.4 In-house 10-264 (270) alignment 
Range on Protein: 149-396
Range on HMM: 10-264/270.0
HTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGhkDCTNEYINACYINDY-SNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQ
.. ..  .  .| |||.|.|.     |..| ...   | . .|||| |.. . ... .|||..||. .|| .|||.||.||.. |.|.|.. |.|. ||.
sesdlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCe

QYWPDSDTK----NYGPFSVTLNDEQVLTDYTVRKMHVKlvDSNDQPPLMitQYHFTSWPDHGVPEYAT------SILQFHRRIKNEYKPT-KG-PMLVH
.||| .  .    ..|  .|.   |.  . | .......  .. ..  |.   .....|||||||. .       ..|.  | ...  | . |. |.|||
rYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvH

CSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
||||||||||..|.|....  |... .|...||...|..||..||. .|| |.  ||.| .
csaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_PTPRN_pd Subfamily PTPRN 145-397 4.3e-62 204.5 In-house 41-293 (297) alignment 
Range on Protein: 145-397
Range on HMM: 41-293/297.0
GESE-HTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKdcTNEYINACYINDYS-NQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEG
 |.| .| .|. .  |   || .... ||..|..|.  . ..  ...||||  | |    .  |||||||...|. |||...|.. . .|...|.. |||
yeaepstkevakaeknvkknrskavlpydhsrvklkeeasae..ksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeeg

KVKCQQYWPDSDTKNYGPFSVTLNDEQVLT-DYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVG
  .|..||||  .. |. . | |  | . . || || ...| .....     .||.|| |||..|||  | |.|.| |..   |.    |..||||.|.|
vkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset..rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG

RTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
|||....||. |..  |    |||.. .. .|.|| ..|.| ||. |.  || | | 
rtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevn
0042113 (Phosphotyrosine protein) phosphatases II 443-677 6.7e-62 204.4 In-house 6-243 (245) alignment 
Range on Protein: 443-677
Range on HMM: 6-243/245.0
ASQNKDKNRSKQFLPPDNYRVPLKGEH----PDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPStPSGM
   ||||||....|| |. || |. .      ||||| ...||. .. ||..  |. .|  .||.|. . ..|.||||. | |.... |.||||.  . .
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

ILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCK
  |.. ..|||||....|. |..||. . .. .. |..|. ..|.  |  ......| ..|.. . ... .|. ..||||. |.|...|.|| . ..  .
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqle

TEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
.|. .......|  | |.||.||| .||. . ...| .|
kelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 438-677 4e-61 202.1 In-house 3-246 (249) alignment 
Range on Protein: 438-677
Range on HMM: 3-246/249.0
VTHNIASQNKDKNRSKQFLPPDNYRVPLKG----EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPS
... .   ||||||.. .||.|. || |.     .. ||||| .|.||. |..||..  |. .|  .||.|. . ..|.||||... |...| |.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

tPSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVSRSAMFCAAAT
  . .  |.. ..|||.|....|. |..|.. . .| .  |...|.|.|  .|   .....|  ||..   ...   .. ..||||. |.|...|.|| .
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
 ..  ..|. .|.....|  | |.||.||. .||. . ...| .|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 414-682 1.1e-60 200.4 In-house 18-288 (319) alignment 
Range on Protein: 414-682
Range on HMM: 18-288/319.0
TKTGQTGYEEQFTVLQQVTQRpdEVTHNIASQNKDKNRSKQFLPPDNYRVPLKG----EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 .||.|. |..|  |.. ..   ....    .||.||| .. |. |. || |.     |  |||||.||.||.|...|| . .|. ||  .||.|. ...
astgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeee

VTAIVMLCHENENNQEVCYQYWPSTPSgMILGEYNIKLLSEETHNGYIERKFEVKQTNTGA-TQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR
.  .|||.. .|. .  . .|||..   .  |.. ..|..||  ..|| ||..... ..   | .|...| |.|   .  .. ...| ..... ....| 
ssivvmltklveklkvklkkywpeenf.eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt

GNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFET
 .  ||||||. | |   |..   .... | |||.|||.. .  |.|..  ||. .||..|....| ......|
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 444-685 2e-60 199.1 In-house 7-250 (250) alignment 
Range on Protein: 444-685
Range on HMM: 7-250/250.0
SQNKDKNRSKQFLPPDNYRVPLKGEH----PDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEvCYQYWPSTPSgMI
 |||.|||  .... |. || |. |.     |||||.|..||.|.||||.. .|. .|  .||.|. ......||||   .|.... . ||||   .  .
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka.ek

LGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKT
 |.  ..|||.|..  |. ||. . ...    . | |.. ..|   |   . ...| ..... ..|.. ||. ..|.||  |.||  |.|  . ... |.
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFETYSN
| |.|||.|.|  |...|..|.. .||  ...|.| .|||.| |..
ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_PTPN1_pd Subfamily PTPN1 143-398 4.2e-60 197.9 In-house 16-273 (290) alignment 
Range on Protein: 143-398
Range on HMM: 16-273/290.0
DSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEG
.   |......  . .|. |||. ..  ||  ||.|.      .  |.||||  ..    . .|| ||||..||   ||...|..||  ..|. .|.|..
rkeasdfptreaklpenrnlnryrdvspydhsrikle......radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke

KVKCQQYWPDSDT---KNY--GPFSVTLNDEQVLTDYTVRKMhvKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVH
..||.||||  .      .    ..|.|  |..   ||||..  .| . . |    |...|.|.||| ||||  .. |.|  ....    .. .|| ..|
qikcaqywPqgeeekellledtklkvkliseerksyytvrll..elenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavih

CSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTX
||||.||.|||. .|  | . ||..    .||   .  .|..|. ..|||||  |   |.|| .  
csaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 118-399 7.5e-60 197.6 In-house 5-282 (439) alignment 
Range on Protein: 118-399
Range on HMM: 5-282/439.0
DKFGEFVAKGHAKGNKGFRNQFGMLDSGESEHTVTVGLT--SSNKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYINDYSNQYQYIATQGPVSN
|.| | | | . . .. |.. | ...| . ....   |.  . ..  ||. ... .|  |.||. . |       |||| ||. | ..  |||||||  .
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvph..shyinanyikGyyddklyiatqgpkke

TLVDFWRLIWQEKSPIIIMITNVIEEGKvkcqqYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSIL
|  |||||....|.  |.|.||..|  |     ||| ..   ||  .|  . .  | .|..| ..|     . .    . |.|...|||. ||  |. .|
ttddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl

QFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTXX
.| | |.  . |   ||..|||||||||||| .|.|. |.|   |  .||  |.. .|.|| .|||.  ||.|. .|||| .   
dflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyG
subfamily_PTPN14_pd Subfamily PTPN14 150-396 4.6e-59 194.9 In-house 40-296 (300) alignment 
Range on Protein: 150-396
Range on HMM: 40-296/300.0
TVTVGLTSSNKLLNRFANIVVYDDNRITLRPMsghKDCTNEYINACYIND--YSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQ
.....    |.  ||| ... |.|||. | |    |. ...||||  |.    .....||..|||. .|. |||...|...  .|.|.|. .|.|| |. 
llstaklpenaeknrfkdvlPyednrvelspt...kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

QYWPDS----DTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMITQYhfTSWPDHGVPEYATSILQFHRRIK------NEY---KPTKGPMLV
.|.|..    .| ..| | || .  .  . .. .....| . |...  ... ||  | ||||||||  .. |.. ....      |.    | .| |.||
kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlv

HCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
||||||||||  .  |. ..  |..  ||| ....|.|.||| .|||  || || .......
hCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Ptp69D_pd Subfamily Ptp69D 414-680 4.7e-57 188.4 In-house 15-289 (307) alignment 
Range on Protein: 414-680
Range on HMM: 15-289/307.0
TKTG--QTGYEEQFTVLQQVtQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLK----GEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDD
.. .  . |... .  |..  . . . .      |. |||...  . |..|| ||     |. ||||| ||.|||||| ||.|  |. .|. .||.|| .
srkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiae

RNVTAIVMLCHENENNQEVCYQYWPSTpSGMILGEYNIKLLSEETHNGYIERKFEVKQTN-----TGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMY
 .|| ||||  ..| |.. | .|||     .  |. ..|| |||.|. ||.|...| ...       ... |.||. |.|. .     ....| .||...
qevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvr

RTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSF
  ...  .. ||||||  |.||..| | .  ....|.|  .|.|.. |  | |..  ||  .||. ... .| | .  
elykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_PTPRA_pd Subfamily PTPRA 440-676 6.7e-56 184.5 In-house 50-294 (330) alignment 
Range on Protein: 440-676
Range on HMM: 50-294/330.0
HNI--ASQNKDKNRSKQFLPPDNYRVPLK---G-EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPS
 ..    .||.|||  . || |  || |    | |. |||||.||.|||||. || |  |  .|  .||.|| ... ..|||| . .| ..| |.||||.
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

TPSgMILGEYNIKLLSEETHNGYIERKFEVKQ----TNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNtSIVVHCSDTVSRSAMFCA
  . .  |. ....  |.  . |  ||| |.|    |.  ... |.|.  | |   |  ..|. .| ..... ..... .. .||||||  | |.  |..
eGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfiv

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTY
  . ... |.|...|||...|. | |.|  ||| .||. |....| |
ldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRG_pd Subfamily PTPRG 416-682 3.2e-55 182.4 In-house 16-292 (563) alignment 
Range on Protein: 416-682
Range on HMM: 16-292/563.0
TGQTGYEEQFT-VLQQVTQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLK---GEH--PDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 |..|..|.|  . ......  ...|  . .|| |||  . .. |. || |.   |..   ||||| .|.||. .||||..  |. .|.  ||.|| ..|
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

VTAIVMLCHENENNQEVCYQYWPStPSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQS------VTQYQITNWDSTGKLTNPQTILLVIEEMYR
|. |||.   .|.... | .|||.    . .|. ...| .||..  | .|.. .|...  ....      |.||. |.|  .|  . .   |  ..   .
vaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssa

TQRKrGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFET
....     ||||||  |.|. ....  | ... ..| ...||..||  | |..  |||  ||. .....|  . | ||
anka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
0037934 (Phosphotyrosine protein) phosphatases II 442-676 5.1e-55 182.0 In-house 6-241 (243) alignment 
Range on Protein: 442-676
Range on HMM: 6-241/243.0
IASQNKDKNRSKQFLPPDNYRVPLKGehPDYINAAFINGYKeKkaFIIAESPMFNTARN----FWKMIDDRNVTAIVMLCHENENNQEVCYQYWPstpSG
.  .|..||| . .|| |. || |.|   ||||| .|.... .  .|.   |. .|  .    ||.|. . ..|.||||... |...| |.||||   ..
llpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...ge

MILGEYNIKLLSEETHNGYIERKFEVKQTN-TGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRK-------RGNTSIVVHCSDTVSRSAMFCA
.  |.. ..|||||....|. |..... .. .. |. |..|. ..|   |  ..|. .|  ..|..  ...        ..  ..||||  |.|.....|
vtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

AATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTVQQYQVIFQIVLTY
| . . ..   | .|.....|  | |.|| .||| .||. . ...| .
aylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_CG7180_pd Subfamily CG7180 153-396 1.5e-54 179.7 In-house 36-290 (296) alignment 
Range on Protein: 153-396
Range on HMM: 36-290/296.0
VGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDCTneYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKvKCQQYWPD
 || . |.  ||  ..| || ||. |. . |...    |||| |.. .  . .|| |..|. .|. .||||...|..  ....|.. .  | ....||| 
gglrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpn

SDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLV--------DSNDQPPLMITQYHFTSWPD-HGVPEYATSILQFHRRIKN-----EYKPTKGPMLVHCSA
   ..||.. | .  |. ... . |.....             . .  .......| |.  . ||  ....... ||..      . .|..||..|..| 
kskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssd

GVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
|..|.| ..|||. |...|||. .|.   . ..|..| ..|.. ..| .. | .|| |
GasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 415-681 2.5e-54 179.3 In-house 17-285 (288) alignment 
Range on Protein: 415-681
Range on HMM: 17-285/288.0
KTGQTGYEEQFTVLQQVTqRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKG----EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
....||..|.. .| ..  . ..||    ..|..||| .. || |  || ||.    .  |||||..|.|.|.||..| . .|. .|  .||... ....
arnrtgfseeynsLaale.ktksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkt

TAIVMLCHENENNQEVCYQYWPSTPSGMILGEYNIKLLSEETHNGYIERKFEVKqtNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRgN
. |||| .  |.... | .|||..      |. ...|..... . ...||....   ..    .|||| . |  .|   . . .| ... .  .. .   
stivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.t

TSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL--DSFE
  |.||||. | |.  | |. . |.. ..| .|||. ...  | |..  |||..||. |....|.    |. .
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgva
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 413-679 9.4e-54 177.4 In-house 9-278 (281) alignment 
Range on Protein: 413-679
Range on HMM: 9-278/281.0
NTKTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNKDKNRSKQFLPPDNYRVPL----KGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDR
...  ..|. |... |... .. .  |   | .|. ||| .     |. || .    . .. ||||| |..|||..|..|....|. ..  .||.|. ..
lsqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

NVTAIVMLCHENENNQEVCYQYWPSTPSGMILGEYNIKLLSEETHNGYIERKFEVkQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKR
.|.||||. .| |...  |..|||   | ...|.. .| ..||... ||||||.. ....| |..|.| . |.|  .|  .... .|   .|......|.
kvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekk

GNTSIVVHCSDTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDS
 ....|.|||  | |.  . |  . ......|   .|| .|... | ..   |||| ||. ....|| .|| 
tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 159-393 8.4e-53 174.0 In-house 38-274 (287) alignment 
Range on Protein: 159-393
Range on HMM: 38-274/287.0
NKLLNRFANIVVYDDNRITLrpmSGHKDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDT-KN
.   ||.|... .||.|. |   | . .   .|||| |.  | .. ..||.|||.. |. ||||......|  .|..|  .||.. || .|||. .    
avkknryadvlPiddtrvll...saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmr

YGPFSVTLNDEQVL-TDYTVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-----KPTKGPMLVHCSAGVGRTGTFMAIDM
 | .||.| | ...  .|.|| . .  .....    .. |... ||||....  | ....|   .|.           ||..||...|.||.|...|. .
vGGysvvlldydikePeygvralrlidletrea..rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlv

GLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVL
 ... |. | .|.  .. |.|..|  .||.. |. .. .|. 
lvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0051429 (Phosphotyrosine protein) phosphatases II 189-397 1.3e-52 174.4 In-house 4-226 (272) alignment 
Range on Protein: 189-397
Range on HMM: 4-226/272.0
NEYINACYINDYsnqYQ------YIATQGPVSNTLVDFWRLiWQEKSPIIIMITNVIEEGKVKCQQYWP------------DSDTKNYGPFSVTLNDEQV
. |||| ... |   ..      .....||  .|  ||||| ....   |...... | |..|| .|||            .  | .|| ..|||  |..
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LTDYTVRKMHVKLVDSNDQPpLMITQYHFTSWPDHGVPEYAtsILQFHRRIKNeykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID-------
|.||..|.. ..|. |.... ......|.|.|||||||. |  .|.. . . .     .||.|||||||..||||. |... |.. ..|  .|       
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
 .  .....|.||...||| .||.|. .|.|| . 
yleeaveelraqrpgavqteeqylflyeallellr
subfamily_PTPRB_pd Subfamily PTPRB 412-679 4.4e-52 171.9 In-house 18-287 (293) alignment 
Range on Protein: 412-679
Range on HMM: 18-287/293.0
PNTKTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNKDKNRSKQFLPPDNYRVPL----KGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDD
 ...  .... |..  |..| .   .|. . ...|..||| .. || |. || |    . .. ||||| .|.||. .. || .  |. .|  .||.|. .
kmkadsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwe

RNVTAIVMLCHENENNQEVCYQYWPSTPSGMILGEYNIKLLSEETHNGYIERKFEVKQtnTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQ-R
.....|||| .  |. .. | .|||.. . .. |. ...|..||. . .. |......  . ....|.||. | |   |   ...|.|  .... ... .
kkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek

KRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDS
.  .. ||||||  | |.  | |  . ... ..| ..|.| .. . | ..   |||..|| .| | ||..| .
taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPN23_pd Subfamily PTPN23 415-677 5.2e-52 171.4 In-house 11-280 (288) alignment 
Range on Protein: 415-677
Range on HMM: 11-280/288.0
KTGQTGYEEQFTVLQQVTQRP-DEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTA
  |.|. ...|  |.|  ..   . .  ||  . .||||.  || |. || |.|.. |||||.|...       ||.. .|. .|.  ||.|. .. .  
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLCHENENNQEVCYQYWPSTP-SGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVI---EEMYRTQRKR
|||| ...| ... . .|||.     .  |.... | |... . ..||.....  .. |..||.  |.|.| . |    |.|.| ..   |..|......
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrk

GNTSIVVHCSDTVSRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
 .| .|||||  | |. .|.   . ... .  .|..|. ||..  | |.  .||...|..  ...||.. 
sktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPRK_pd Subfamily PTPRK 443-675 6e-52 171.4 In-house 40-275 (314) alignment 
Range on Protein: 443-675
Range on HMM: 40-275/314.0
ASQNKDKNRSKQFLPPDNYRVPL---KGE-HPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTpsGM
  .|..||||.. |..|. || |   .|. . ||||||.|..||  .|||..  |. .| ..||... | | ..|||| .  |. .  |..|||    ..
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed..te

ILGEYNIKLLSEETHNGYIERKFEVKQ--TNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKrGNTSIVVHCSDTVSRSAMFCAAATTINK
. |. ...|.. |... .. | | |..   .  ... | |.| ..| . .  .. ...| .. ..  .| . ..  ||||||    |. .|.| .. .. 
vygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldm

CKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLT
 ..|||.|||.. |. | .|.  |.| .||. |....| 
ieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 416-679 2.7e-51 169.6 In-house 20-290 (325) alignment 
Range on Protein: 416-679
Range on HMM: 20-290/325.0
TGQTGYEEQFTVLQQVTQRPdeVTHNIASQNKDKNRSKQFLPPDNYRVPLKG----EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNvT
  | |.  .| .|  .       .     .||.||| |  .. |. || |.      . |||||.... .|.|. |. | .|. .|  ..|... | . .
qdqdgfahefgllpsddgia..kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.c

AIVMLCHENENNQEVCYQYWPST-PSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVI---EEMYRTQR-
..|..  | ..... | .|||        .|  ..|| . |.   |. |...|||.. | |.|| |.|.  ||  |    | |.. ..   ...  . . 
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

-KRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDS
  .. | |.||||. | |. .| .  . ..|  .|  .|.|...|  | ..|  |.|| || .|.. .  .. |
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 115-396 2.8e-51 169.1 In-house 4-236 (392) alignment 
Range on Protein: 115-396
Range on HMM: 4-236/392.0
IPVDKFGEFVAKGHAkgNKGFRNQFGMLDSGESeHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYINDYSNQYQYIATQGPVS
||| .|  || | .   .  | ..|  | . .  .  ||. .  |.  ||. ||. || .|. |  .    |  ..|.|| ||. . |.  |||.||| .
ipvaqfpafveknrh..salffeefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddipd..sdylnasyipsfdnekayiasqgpna

NTLVDFWRLIWQEKSPIIIMITNViEEGKvkcqqywpdsdtknygpfsvtlndeqvltdytvrkmhvklvdsNDQPPLMITQYHFTSWPDHGVPEYATSI
 .| ||||...||.   |.|.|.. .||                                            . .    ..|.||| |||..||....|.
aslddfwrmvfqenvttiamvtkl.kegd...........................................kgddartvaqfhftewPdkdvpkhtssl

LQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
|.| . .| ..     |...||||||||||  ..||  . .|.|   .|.. ..  .|..|  |||| .|| |.  |||| .
lkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_PTPN12_pd Subfamily PTPN12 415-677 3.3e-51 168.9 In-house 4-277 (290) alignment 
Range on Protein: 415-677
Range on HMM: 4-277/290.0
KTGQTGYEEQFTVLQQVTQRP--DE---VTHNIASQNKDKNRSKQFLPPDNYRVPLKG----EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMI
|.|.  ....|. |......   ..    ..  ...|. ||| |  || |. || |.     |. ||||| ||.| ..|...| | .|. .|  .||.||
kegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmi

DDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMI-LGEYNIKLLSEETHN-GYIERKFEVKQTntGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYR
.. ||. .||.|.| |...  | .|||..    .  ||....| .|.. . ... | ..|..   .....|.|.. |.|   |  ......| .||.. .
weknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvre

TQRkRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
.|. . .. .|||||  | |    .|   . .  |.| .   .|||... . | |..  ||| .||..... |. ..
lqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN6_pd Subfamily PTPN6 409-679 5.8e-50 165.0 In-house 16-299 (306) alignment 
Range on Protein: 409-679
Range on HMM: 16-299/306.0
MNEPNTKTGQTGYEEQFTVLQQVT-QRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLK---GEHPDYINAAFINGY--KEKKAFIIAESPMFNTARNFW
... .......|.||.|  |||   ..  . ..    .|| ||| |  || |. || ||       ||||| .|..   ...|..| ..  . .|  .||
lekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

KMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMILGEYNIKLLSEETHNGYIERKFEVK-QTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEM
.|. . | . |||. .|.| ..| |..|||.. .    |..... .||.... || |.. |. ... . ...| ||. ..|   |  ..|...|  .|..
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledv

YRTQRKRG---NTSIVVHCSDTVSRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDS
 | |..     . .||||||. . |   |    . ... ...|.   ||. .. || | |. | ||| |||. ..... .|...
nrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 438-682 8.7e-50 164.5 In-house 40-289 (297) alignment 
Range on Protein: 438-682
Range on HMM: 40-289/297.0
VTHNIASQ---NKDKNRSKQFLPPDNYRVPLKG--EH--PDYINAAFINGYKEkkAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQeVCYQY
.. .  ..   | .|.| |  || |  || |.   ..   ||.||.|..|.|.   .|  . || .|  .||.|. | .|..|||| ..||...  | .|
iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPSTPSGMiLGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLT--NPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFC
|. . .   .|.  ..||| .  .|.|.|..||.. .. |.. | ||| ..| .       . ...| .|.|.  .  .. .. ..|||.  | | ....
Wsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

AAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSFET
.    . . | |  .|.|...|  | ..|  ||| .||. ....|| .| | .|
tidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 441-678 2.7e-49 162.7 In-house 39-278 (315) alignment 
Range on Protein: 441-678
Range on HMM: 39-278/315.0
NIASQNKDKNRSKQFLPPDNYRVPL----KGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPS-TP
   ..|  ||| |  || |. || |    .  . |||||..|..... ||.| .  |   .  .||.|. . .||.|||. . .|...  | ||||    
aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

SGMILGEYNIKLLSEETHNGYIERKFEVKQTNtgATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVSRSAMFCAAATTIN
  . .|.....||| |.  . . ||. .....  ... |||.| |.|   |   .  ..| .| |.    ... . |..||||  | |. .....   ..
dsvefGsikvellsleadtdgvarklvtrkse..esrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevva

KCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLD
. | . ..|||...|  | ..|  ||| ..|  |...|| .| 
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 414-678 3.3e-49 162.3 In-house 12-277 (515) alignment 
Range on Protein: 414-678
Range on HMM: 12-277/515.0
TKTGQT-GYEEQFTVLQQVTQRPDEVTHNiaSQNKDKNRSKQFLPPDNYRVPL----KGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDR
.| ..|  . |.|  |      |. |. .    |  ||| |  || |. || |       | ||.||..|....  ||.| .  |   .  .||... . 
nknrhttlfseefhdlpgpniypqtvaqe..einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqe

NVTAIVMLCHENENNQEVCYQYWPSTPSGM-ILGEYNIKLLSEETHNGYIERKFEVKQTNTgaTQSVTQYQITNWDSTGKLTNPQTILLVIEEMyRTQRK
|||.|.|. . .|...  | .|||  |.    .|.....|.| |.  | | ||..| . .   .. |||.. |.|   |   . ...| .| |. .... 
nvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikev.kadhg

RGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLD
. . ....|||  | |  .....   . . ||  ..|||....  | ..|  ||| .||  |...|| .| 
qythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 418-675 1.1e-48 161.1 In-house 33-289 (319) alignment 
Range on Protein: 418-675
Range on HMM: 33-289/319.0
QTGYEEQFTVLQQVTQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLK---G-EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
.| .| .|  . ...    . |.    |||||||  . |. |. .| |.   | |  |||||.|..||. |. .| |  |. ||  .||.|| . |...|
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLChenennQEVCYQYWPSTpSGMILGEYNIKLLSEETHNGYIERKFEVKQ-TNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEE-MYRTQRKRGNT
|.|       .. | ||||     .  .....|. | |  . |. |..|. . ..    ...||. .  |   |.   |  .. ...   . |.......
vllt......kdkcsqywplk.ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra

SIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLT
.||||||  | |. .. .  . ... | |  .||.....  | |..  || . ||. |.  .| 
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 436-675 1.8e-48 160.5 In-house 15-253 (284) alignment 
Range on Protein: 436-675
Range on HMM: 15-253/284.0
DEVTHNIASQNKDKNRSKQFLPPDNYRVPLK---G-EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenennQEVCYQYW
 . |.    |||||||  . |. |. .| |.   | |  |||||.||.||. |. .| .  |. ||  .||.|| . |...||.|       .. | |||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PSTpSGMILGEYNIKLLSEETHNGYIERKFEVKQ-TNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEE-MYRTQRKRGNTSIVVHCSDTVSRSAMFCA
|     .  .....|. | |  . |. |..|. . ..    ....|. .  |   |.   |  .. ...   . |........||||||  | |. .. .
plk.ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLT
  . ... | |  .||.....  | |..  || . ||. |.  .| 
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 419-675 2.1e-47 156.6 In-house 24-277 (315) alignment 
Range on Protein: 419-675
Range on HMM: 24-277/315.0
TGYEEQFTVLQQVTQRPDEVTHNIasQNKDKNRSKQFLPPDNYRVPL----KGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIV
 |.....  .     .| .|...|  .||.|||  . .. |. || |    . .| ||.||.||.||. |. .| |..|  .. ..||... . ... ||
ngfkqdyesipggqlhpldvakki..enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkiv

MLCHENENNQEVCYQYWPSTpsGMILGEYNIKLLSEETHNGYIERKFEVkqTNTGATQSVTQYQITNWDsTGKLTNPQTILLVIEEMYRTQRKRGNTSIV
||    |.... . .|||     .| |.. . . ||| .. |  | . |  .     . | |...| |  . ....  . |. .    .  ..   ..||
mltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsv..vfgdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaiv

VHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLT
||||. | |.  |..  . ... ..| .|||.....  | .. . ||...||| |....| 
vhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
0041856 (Phosphotyrosine protein) phosphatases II 159-395 2.7e-47 156.0 In-house 1-170 (182) alignment 
Range on Protein: 159-395
Range on HMM: 1-170/182.0
NKLLNRFANIVVYDDNRitlrpmsghkdcTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITnvieegkvkCQQYWPdsdtkny
|. .||. .|. || .|             . |||| ..  .  . ..||||||  .|. ||.|......  .|...|         . .|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

gpfsvtlndeqvltdytvrkmhvklvdsnDQPPLMITQYHFTSWPDHGVPEyATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQaek
                             .  . ...||....|||||||.   ..|.| .....     .|| |||||||||||||. |... ...   
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl...

egGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLES
  |... .... .|..|..||.| .||.|. .|.|| 
..gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 444-678 1.2e-46 154.1 In-house 26-269 (274) alignment 
Range on Protein: 444-678
Range on HMM: 26-269/274.0
SQNKDKNRSKQFLPPDNYRVPLKGE-----HPDYINAAFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSG
. .. ||| |. || .| || |. |       .|||| .| ||.| .||.. .  |. ||  .||.||  ..|. |||| . .|.|.. | .|.| . . 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

MILGEY---NIKLLSEETHNGYIERKFEVKQTNTgaTQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNT--SIVVHCSDTVSRSAMFCAAAT
 | ..|   .||  .  ..|.|  ||. .|...   ..||. |  |.|  .    ...|.| ...|. ...... .   ..|||||  . |  .| |.  
eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLD
.... . |.|.||...    |... | ||| .||..|....  || 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN3_pd Subfamily PTPN3 438-675 1.1e-45 150.7 In-house 33-273 (280) alignment 
Range on Protein: 438-675
Range on HMM: 33-273/280.0
VTHNIASQNKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFIN----GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPS
...   ..| .||| .  || |. || || .. ||||| ..|    . .  . .|..  |. .|| .||.|. ..... ||||    |. .  |.||||.
isaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

TPSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMyRTQRKRGNTSIVVHCSDTVSRSAMFCAAATT
|   . .||...|. .|.... |. |.. .|...|   ....| | ..|   |  .... .| ..|.. |..|.  .. .|||||  . |. .. .  |.
tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilleta

INKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLT
. .  ..  . . ....  | |.   |||..||. . . .| 
lalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
0036282 (Phosphotyrosine protein) phosphatases II 189-390 3.5e-45 149.1 In-house 2-164 (174) alignment 
Range on Protein: 189-390
Range on HMM: 2-164/174.0
NEYINACYINDYSNQYQYIATQGPVSntlvdFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDsdtknygpfsvtlndeqvltdytvrkmhvklvdSND
. |||| ... .     .||.||| .     ||........ ...| .. .| |..|| .|||.                                   .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

QPPLMITQYHFTSWPDHGVPEYATsILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEkEGGIDIISIINRMRQQRMKMVQTADQYIF
 .  .. ||... |||||||. .. .|.| ..... ..   .||.|||||||||||||..|... |.. . |. .|..... ..|.||..|||| .||.|
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

VND
. .
lyy
subfamily_CG7180_pd Subfamily CG7180 434-677 5.6e-45 148.2 In-house 30-290 (296) alignment 
Range on Protein: 434-677
Range on HMM: 30-290/296.0
RPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLK---GE-HPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQeVCYQ
. ..  ... ..|..|||  . .|.|. || |.   || . |||||......  ||..|. | |. .|  .||... |... |.|.|... . ..  . .
eigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myps

YWPSTPsGMILGEYNIKLLSEETHNGYIERKFEVKQT----------NTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRG-----NTSIV
||| .      ||  .....|..      |.| ....           .  |  |...|.| |..  |.    . |. . .. |. |..      .  .|
ywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
|..|| .||| ...|.  .... . |. .|||. .|  |...|. |..|..|. |....| ..
vvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 162-394 7.8e-45 147.7 In-house 59-281 (290) alignment 
Range on Protein: 162-394
Range on HMM: 59-281/290.0
LNRFANIVVYDDNRITLRpmSGHkdcTNEYINACYINDYSNqyQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTK--NYG
 ||. ..|  |  |. |.   |.     .|. | |..       .| |||.. .| .|.||.. |||   |.|. ..||.|| ||.||.|. . .   .|
knrykdvvcndktrvilk..dGy...dGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

PFSVTLNDEQVLTDYTVRKMhVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE
 ..|.   |.   . ...|. . . | ..    ..  ..  ||||. |.  . ..|.  | ...    . ||. ||||||.||||||.||..|||   . 
eitvlcseeddkdaniikkt.lsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldG

GGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
  .|.. ..  .|. |.. ||   ||. . ...|.
keldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_PTPN13_pd Subfamily PTPN13 421-679 6.5e-44 145.2 In-house 13-271 (273) alignment 
Range on Protein: 421-679
Range on HMM: 13-271/273.0
YEEQFTVLQQVTQRpDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEHPdYINAAFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
 .|.|. |...    |...     .|||||| .. || |. ||.|..| . ||||..|.    |..  .|..  |. .|...||.|. ..... |.|. .
Paeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

ENENNQEVCYQYWPSTPS--GMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkrGNTSIVVH
| |...  | .|||.. .   .. . ....||  . ..|.  |...||....|... |.. . ..|   |  .... .| .. |. | |.   .. ||||
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvh

CSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDS
||  . || .. .  . ..  . .  .|| ..... | |. | ||| .||  .....|. | |
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_PTPN9_pd Subfamily PTPN9 415-677 8.2e-44 144.8 In-house 12-290 (297) alignment 
Range on Protein: 415-677
Range on HMM: 12-290/297.0
KTGQTGYEEQFTVLQQVTQRpDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKG----EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
..|. |  .... ... .    ....     |  ||| .  |  |. || |.     |. ||||| |..|||.||||| .  |. .| ..||.|. ...|
ekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqev

TAIVMLCHENENNQEVCYQYWP-STPSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQR---
  |||  .  |. .  | |||| .. | .  |..... .. |... | .|..|.|...|. ...|| .|.. |   |   . ...| |.|.. ..|    
lvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalav

------KRG---NTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
      ..|   .  ||||||  . |.  |..   .... ...|..||....|  | |.  |.|| .||.  .. || | 
kelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 147-394 1e-43 144.3 In-house 21-257 (267) alignment 
Range on Protein: 147-394
Range on HMM: 21-257/267.0
SEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEgkvKC
 . |..  ... |.  ||. . . |||.|. ||      . ..||||| |.. |  . ..|.||.|..||  ||. .| ..| |.|...|.| ..   . 
tsstisqsiaeknqernrlddnlpyddtrvilr......tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...ni

QQYWPDS--DTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQpplMITQYHFTSWPDHGVPE-YATSIlqFHRRIKNEYKPTKGPMLVHCSAGVGRT
...||    ..|.|  ..|  . |.   || .  . .|. . . .    .| |..  |      . |   .  |    ||. .    |..|.||.||||.
rlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesah...nvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrs

GTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
|||. ||  |..| .||  ||   . ..|.||. .|.| ..||.. . . |
Gtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 442-678 6.4e-43 141.7 In-house 16-265 (270) alignment 
Range on Protein: 442-678
Range on HMM: 16-265/270.0
IASQNKDKNRSKQFLPPDNYRVPLKGEHPD----YINAAFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPS
 | ..|  ||... ||  . || |. .. |    |||| ...|... ||..| | .|. .| ..||.|| ...||||||. . .|.... | .|||. | 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

G---MILGEYNIKLLSEETHNGYIERKFEVKqtNTGATQSVTQYQITNWDSTGKLT------NPQTILLVIEEMYRTQRKRGN-TSIVVHCSDTVSRSAM
    .  |. ..  |||| ..||| .. ...  ..| .. .. .. ..|   |  .      ... .| ..... |....  . . ..||||. | |. .
ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLD
. |  ....  .... .|| ....  | ...  ||...||. ... |..| .
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0043147 (Phosphotyrosine protein) phosphatases II 189-388 1.1e-42 141.1 In-house 5-153 (172) alignment 
Range on Protein: 189-388
Range on HMM: 5-153/172.0
NEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVieegkvkcqqywpdsdtknygpfsvtlndeqvltdytvrkmhvklVDSND
. |||| |.. |    ..|||||| .||| ||||......  .|...|.                                              .   .
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydpe

QPPLMITQYHFTSWPDHGVPeYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRMKMVQTADQYIF
.   .. ||....|||||||  .  .|.| . |..   .  .||.|||||||||||||. |... |       |...  ... .|..|...||. .||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

V
.
l
0046846 (Phosphotyrosine protein) phosphatases II 189-393 1.2e-42 141.0 In-house 12-170 (176) alignment 
Range on Protein: 189-393
Range on HMM: 12-170/176.0
NEYINACYINDYsnqyQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDsdTKNYGPfsvtlndeqvltdytvrkmhvklvdsnd
  |||| .|  .     .||||||. .|| ||........  .....|. .| |..|| .|||.   ...|                             
ldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi............................

qpplmitQYHFTSWPDHGVPEYaTSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDmglqQAEKEGGIDIISIINRMRQQRM-KMVQTADQYIF
       ||... |||||||.. . .|.. . |.. .|   || |||||||.|||||. |..      |.| |...  .. ..|.||. ..||| .|| |
.......qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrf

VNDAVL
. ...|
lyefel
0049260 (Phosphotyrosine protein) phosphatases II 196-389 1.2e-42 140.5 In-house 1-143 (152) alignment 
Range on Protein: 196-389
Range on HMM: 1-143/152.0
YINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWpdsdtknygpfsvtlndeqvltdytvrkmhvklvdsndqpplmit
.|. | .....|||||| .||| ||||.... .  .|.|.|.  | ||.|| ||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRMKMVQTADQYIFVN
||... |||||||. .  .|.... |.  ..  .|| |||||||||||||..|... |       |...  .....|..|...|.. .|..|. 
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 420-676 2.3e-42 139.9 In-house 7-258 (267) alignment 
Range on Protein: 420-676
Range on HMM: 7-258/267.0
GYEEQFTVLQQVTQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHE
 .|..|  ......    ..  ||..|...||  . || |. ||.|. .  .||||....||| |.|||. . |. ||  .|...| |..|. ||.| . 
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv

NENNqeVCyQYWPST-PSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGAtQSVTQYQITNWDSTGKltNPQTILLVIEEMYRTQRKRGNTSIVVHCS
 ..|  .  ..||          .  ..   |.  | |    .|.|  |  | . || |   .|.   .  |   .  ..  . . | . ||  .||.||
ftdn..ir.lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnintn..nkpylkplfgilaknqlengnrPlvvacs

DTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTY
| | ||  |  . . ... ||||| |.|. |.  | |..| |.| ..|  | ...  |
dGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_PTPN1_pd Subfamily PTPN1 430-674 7.4e-42 138.0 In-house 14-268 (290) alignment 
Range on Protein: 430-674
Range on HMM: 14-268/290.0
QVTQRPDEVTH--NIASQNKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVC
....  .....      .|...|| .   | |  |. |. .. |||||....  . |. .|..  |. ||.  ||.|. ...  |.||| .  |..|  |
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

YQYWPSTPS--GMILG--EYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQR-KRGNTSIVVHCSDTVS
.||||.  .   ..|   ....||.|||... |. |..|... .|  |......  | |   |    |.. |  . .. ..   ..     |.|||  . 
aqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVL
||  || . | .    | .    .|. .||   | .. | .|| .| .  .. .|
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylail
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 122-395 2e-41 136.7 In-house 11-286 (305) alignment 
Range on Protein: 122-395
Range on HMM: 11-286/305.0
EFVAKGHAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHkdctnEYINACYINDYSNQYQYIATQGPVSNTLVDFW
.|| .   || .|.|..|  .   .  . .     . ..  ||. ..   |.||. |..   |     ||| | |.   .|  ..| || |. .|  |||
kfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwph.....eyihanyvstptnpkrfictqaplektcadfw

RLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKN--Y--GPFSVTLNDEQVLT-------DYTVRKmHVKLVDSNDQPPLMITQYHFTSWPDHGVPEY
 . .|.|   |.|. |..| |  ||..|..  | .   .  .   ...  |   |       . .|..  | ...   .  . .|.||.  ||| |||  
ymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvte.tvlviegpgekarkvthyhwidwpdrgvpaa

ATSILQFHRriknEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID-IISIINRMRQQRMKMVQTADQYIFVNDAVLES
 ..||..      . .|.|||. ||||||.||||. . ..  |.|      |.    |....|.|| . .|| .||.|| . .|. 
dlailelle....karpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
0049772 (Phosphotyrosine protein) phosphatases II 147-395 4.5e-41 136.9 In-house 34-279 (314) alignment 
Range on Protein: 147-395
Range on HMM: 34-279/314.0
SEHTVTVGLTSSNKLLNRFANIVVYDdNRITLrPMSGHKDCTneYINACYINDYsnqYQYIATQGPVSNTLVDF----------WRLI--WQEKSPIIIM
.|.|..|.    |.  ||. .|. .| ||  | |  .....   |||| |.. .    ..|||||| ..|.|||          ||..  .. .. .| |
peltilvadlflnrdknryldilpad.nrvil.pglpvsgsd..yinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------ITNVIEEGkvkcqQYWPDSDTKNYGpfsvtlndeqvltdytvrkmhvKLVDSNDQPPLMITQYHFTSWPDHGVPeYATS
                     .... . |      ... .| ...                       . ..... .. .. .|. . .||...|     
srdevladelsrLdaAlgKtpllildgng.....neptaadlellk......................eelydpelferlgikylripvpDgsap.lled

ILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAekegGIDIISIINRMRQQRM-----KMVQTADQYIFVNDAVLES
...| . |..   ...|| ||||.||.||||||..... . .     |...  .....|..|.      .... .||.|. .|.|| 
fdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 124-394 7e-41 135.2 In-house 7-275 (307) alignment 
Range on Protein: 124-394
Range on HMM: 7-275/307.0
VAKGHAKGNKGFRNQFGMLDSGESEhTVTVGLTSSNKLLNRFANIVVYDDNRITLRpmsgHKDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRL
| .   || . ....| .|   . | .|||   |.|   ||. .. . | .|| ..     .  . .|| | |.    .  ..|..|||  ||  .|| .
vqrtldkgvqalvdefrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvk....fdglasdyihanylgiaikpkkficaqgplentqysfwam

IWQEKSPIIIMITNVIEEGKVKCQQYWPDSDT--KNYG--PFSVTLNDEQ---VLTDYT-VRKMHVKLVDsnDQPPLMITQYHFTSWPDHGVPEYATSIL
. |||   .||. .||| .|.||.||||  .   . .|  | ......     .  |   .    .|..    |    |... .. |||.|||.   . .
aiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw..aqksrtiqhlqwenwpdrgvpqinltai

QFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQ-AEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
 .   .. .    . |..|||||||||.|| .|| .  ..  . .   |.  ... .|.||   .||  ||...   .||
nlleavryd....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 445-678 4.8e-40 132.1 In-house 37-278 (287) alignment 
Range on Protein: 445-678
Range on HMM: 37-278/287.0
QNKDKNRSKQFLPPDNYRVPL--KGEH-PDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMILG
 .  |||  . || |. || |  .||.  ||||| .. .|....||| | .|.  | |.||... .......... .| |. .  ||.|||     | .|
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYNIKLLSEETHN-GYIERKFEVKQTNTGATQSVTQYQITNWdsTGKLTNPQ---TILLVIE--EMYRTQRK-RGNTSIVVHCSDTVSRSAMFCAAATTI
 | . ||. .  .  |  | . . . .|  .. | |... .|    |   |     | .|..  .    .|.  .   .|||..  . || .. |  . .
GysvvlldydikePeygvralrlidletrearvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

NKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLD
.. .  | .|| .|.   | .. . ||.| |...... . ||  
srledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 135-394 1.7e-39 130.2 In-house 13-267 (281) alignment 
Range on Protein: 135-394
Range on HMM: 13-267/281.0
FRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHKDCTnEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIM
|...|  |        .||     |.  ||..|| . |  |. |.     |. | .|| | ||     .  || ||||  .|  ||||.||||..  |.|
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknst.dyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

ITNVIEEGKVKCQQYWPDSD--TKNYGPFSVTLNDEQVLTDYTVRkmhvKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPM
. ...|  . || .|.|       ..  .||. .|  |           .|  | .    .||.. .  |||  ||| .  .|.  |.|.        | 
lcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvtt....rlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarst....pp

LVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINRMRQ-QRMKMVQTADQYIFVNDAVLE
..||||||||.||.||... ||       . ||  |. ..|   |   ||| .||...   .|.
vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_PTPRN_pd Subfamily PTPRN 422-674 5.9e-39 128.5 In-house 32-289 (297) alignment 
Range on Protein: 422-674
Range on HMM: 32-289/297.0
EEQFTVLQQVTQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGE----HPDYINAAFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVML
|...  | .  . |   .   | .| .|||||..|| |. || || |    . |||||..|     .  |.| ...|. .|  .||.|. .. |. ||.|
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

CHENENNQEVCYQYWPSTPSGmILGEYNIKLLSEETH-NGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGnTSIVV
.. .|.. . |..||| . |  . . |...|.||    . |. | | .|. .|  |..|||.    | ..|  ......|     . .. | |  ..|||
trleeegvkqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivv

HCSDTVSRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVL
|||| . |. ....    .|.  |    ||.   |.  | |.|| |.| .|...... | 
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 156-394 1.5e-37 124.1 In-house 32-268 (285) alignment 
Range on Protein: 156-394
Range on HMM: 32-268/285.0
TSSNKLLNRFANIVVYDDNRITLrpmsghKDCTNEYINACYIND-YSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDS-
  .|  |||.|.. . .. |. |      |.   .|| | ..     .|  ||.||||. .|| |||..|.|||   ..|.  ..| |  ||  |.|.  
yeanpdlnryadvrcieetrvvl......knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

-DTKNYGPFSVTLND--EQVLTDYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKGPMLVHCSAGVGRTGTFMAID
 .  ..| . .|| .  |. ..   .  . |   .     || . . .   |||.  || |  ...... .|.  .| . |. |||||||||| ||. ||
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgid

MGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
    .  ..  |... |.  ||  |.. ||.  |..|.   ..|
yatirimenpniemldivremramrfqavqshmqflflyvvlme
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 121-391 1.6e-37 123.7 In-house 15-285 (310) alignment 
Range on Protein: 121-391
Range on HMM: 15-285/310.0
GEFVAKGHAKGNKGFRNQFGMLDSgESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRpmsGHKDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDF
 .|.      | .|. .|.  ||. . . ..|      .   ||....|. |. |. |.     |   ..|| | |..    .  .| .|||.  |..||
enfiiateklgieglvkqyrklda.kqdssltyeaykkymhknrysdvvcldtsrvklk...idksryedyihanyvktnylrstficsqgplqhtiidf

WRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDS-DTKNYGPFSVTLNDEQvLTDYTVRKMHVKLVDSN----DQPP----LMITQYHFTSWPDHGVPEYA
||.|.||..  |... .| |||. ||  |||    |. ||   ||   |    .. . .. | .|  |    .||     | ..  ..  ||| |||.  
wrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek

TSILqfHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDA
   .   .|.  . .  .|| .||||||..|... .|... ......   .|.  ..  ....|.. .||  ||....  
chtv..pqrllaqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
PTPc_DSPc_SM00012 294-394 7e-37 121.2 In-house 2-105 (105) alignment 
Range on Protein: 294-394
Range on HMM: 2-105/105.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK--GPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMVQTADQYIFVND
...||.|.||||||||...|||.. | .|....  .  .|..|||||||||||||.|.|. ||| ||| . .||  |....|.||..|||| .||.|. .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
0051082 (Phosphotyrosine protein) phosphatases II 189-392 1.6e-36 120.5 In-house 3-149 (151) alignment 
Range on Protein: 189-392
Range on HMM: 3-149/151.0
NEYINACYINDYsnqyqYIATQGPVSntlvDFWRLIWQEKSPIIIMITNVIEEGkvKCQQYWPDSDtknygpfsvtlndeqvltdytvrkmhvklvdsnd
. |||. |. ..     .....|| .    ||..|.....   |.....  | |  .| .|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

qppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekeggIDIISIINRMRQQRMKMVQTADQYIFV
   . ........|||.|.|..  ..|.|.. . .   . .||.|||||||.|||||..|... |..      ... .... .|..|. .||. .|..|.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

NDAV
  |.
lfal
subfamily_PTPN14_pd Subfamily PTPN14 430-678 3.4e-36 119.8 In-house 31-297 (300) alignment 
Range on Protein: 430-678
Range on HMM: 31-297/300.0
QVTQRPDEVTHN--IASQNKDKNRSKQFLPPDNYRVPL---KGEHPDYINAAFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENEN
.....  . . .     .|..||| |..|| .. || |   | .. .||||. |.     ... .|.| .|. .| ..||.|. . .|. |||| .|.|.
ripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeed

NQEVCYQYWPST---PSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNT--------
 .| ...|.|..    . .  |....     |. . .| .....|   ..  ..|   | |.|   |   .... |  .||.   .||  ..        
gkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskP

SIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLD
 ..||||. | |. .   .   |.  ... .||. .||.  | |.   |||. ||. .......||.
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0044763 (Phosphotyrosine protein) phosphatases II 171-390 4.2e-36 119.6 In-house 2-165 (178) alignment 
Range on Protein: 171-390
Range on HMM: 2-165/178.0
YDDNRITLRPMSGHKDctNEYINACYINDYsnqyQYIATQGPvsntlVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTknygpfsvtlndeqv
.|..|  | ...|.     .||||..| ..     |.....|     .|...|.....   |...|. .| |..|| .|||..                 
ldrtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

ltdytvrkmhvklvdsndqpplmiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekegGIDIISIINR
                         ||... .||||||.    .|.|.. |.. ... .|| ||||||||||.||..|... ...     |... ..|..
........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

MRQQRMkMVQTADQYIFVND
.|..|. .|.. .|. .. .
vrerRp.ivpnpgqlrqLye
0051429 (Phosphotyrosine protein) phosphatases II 469-680 4.9e-36 120.1 In-house 3-228 (272) alignment 
Range on Protein: 469-680
Range on HMM: 3-228/272.0
HPDYINAAFINGYKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVMLCHENENNQEVCYQYWP-----------STPSGMILGEYNIKLLSEETHN
 ..|||| ...||     ..... .  |. .||..||..  . ....||.|..|.| ... |..|||           ...  . .| . ..|||||...
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERKFEVKQT-NTGATQSVTQYQITNWDSTGKLTNPqtILLVIEEMYRtqrkrgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVID--------V
 || |..... . ..|..  |.... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSF
.....  | | ||.||| .||. .....| .|.|.
eeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 159-397 1.2e-35 117.9 In-house 43-272 (288) alignment 
Range on Protein: 159-397
Range on HMM: 43-272/288.0
NKLLNRFANIVVYDDNRITLRpmsghkDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDS--DTK
|   .|. |.   |  |. |       | .. ||.|  .    .. . | .| |.  |.  .|... ..    |.|.....| || | ..|.|    .. 
nptrdryenlprcditrvkls......ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

NYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPlMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMAIDMGLQQA
 .| .     ....  | .|.   ..     ...  .. . |.  |.|.||||   | |..  ..|.  |    |..||.|||||||||.. | . |...
rigrlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtlililialesl

EKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVT
  .  . | |.....|..|.| .||  ||..|   ||| . 
rlddflgirsllaklreerfkaiqtemqylyvhrcvleell
0041856 (Phosphotyrosine protein) phosphatases II 446-676 6.6e-35 115.7 In-house 1-170 (182) alignment 
Range on Protein: 446-676
Range on HMM: 1-170/182.0
NKDKNRSKQFLPPDNYRvplkgeHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenennqevCYQYWPstpsgmilgeyni
|.|||| . .||.|. |      ..||||| .. |.   . ||..  |. .|  .|..|. ....|.||.|.         ...|||             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

kllseethngyierkfevkqtnTGATQSVTQYQITNWDSTGKLTnPQTILLVIEEMYRtqrkrGNTSIVVHCSDTVSRSAMFCAAATTINKckteGvIDV
                      .  .. ..||. ..|.  |  . ....|  |||...      .  ..||||  |.|.....||   . .    | ...
......................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsl

FQVLKSQRIQKPGSVQTVQQYQVIFQIVLTY
....|  | ..||.|.| .||... ...| .
eeavklvrsrRpgmvitpnqyfflqlallel
subfamily_ptpA1_pd Subfamily ptpA1 125-349 1e-34 115.0 In-house 13-249 (418) alignment 
Range on Protein: 125-349
Range on HMM: 13-249/418.0
AKGHAKGNKGFRNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGhKDcTNEYINACYINDySNQYQYIATQGPVSNTLVDFWRLI
 | | |  .  ...| .|.        . |    |   ||..||.  .  |. |. .   |.  ..|||| ||.  .   |.|.||||. ||. ||||..
lknhikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqd.ke.gsdyinanyidg.aypkqfictqgplpntiadfwrmv

WQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNygPFSVTLNDEQVLTDYTVRKMHVK------LVDSN-----DQPPLMITQYHFTSWPDHGVPEYATS
|...  ||.|..   |. ..||..|||.    .   ||.  | ..|.  |.|  . |       ..  |     .     ||||..  |||| .|...  
wenrcriivmlsresencrikcdrywpeqigge..qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqp

ILQFHRRIKNEY---KPT---KGPMLVHCSAGVGRTGTFMAI
. |. . | |      |.   . |..||||||||||||| . 
frqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfcta
0036282 (Phosphotyrosine protein) phosphatases II 471-671 1.2e-34 114.9 In-house 3-164 (174) alignment 
Range on Protein: 471-671
Range on HMM: 3-164/174.0
DYINAAFINGYKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPStpsgmilgeynikllseethngyierkfevkqTNTGA
||||| .....   . .|.   |.      ||.|. . ..|..|||..|.|.. . |..|||.                                . .  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lredl

TQSVTQYQITNWDSTGKLTNPQtILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIF
.... ||. ..|.  |  . .. .| ....... . . ..  ..||||  |.|.....||   .   . |...|........| |.||.||| .||. . 
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Q
.
y
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 445-674 3.7e-34 113.0 In-house 2-236 (237) alignment 
Range on Protein: 445-674
Range on HMM: 2-236/237.0
QNKDKNRSKQFLPPDNYRVPLKGE--HPDYINAAFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMILG
.|| |||  .    |  || |||     |||||....|.    | .| |. |. ..  .||.|. . . . ||||    |.|.. |..|||||      |
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

EYNIKLLSEETHNGYIERKFEVKQ-TNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRK-RGNTSIVVHCSDTVSRSAMFCAAATTINKCKT
 . . |  .|    |  | . . . ..    . . |||.| |   |   .  ..|    ..    ..    .  ..|||  | |...|    . . ..| 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

EGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVL
. |.|... ..|   ..|  .|| .|| .|.| .|
kkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 191-388 3.4e-33 109.7 In-house 77-273 (301) alignment 
Range on Protein: 191-388
Range on HMM: 77-273/301.0
YINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTK--NYGPFSVTLNDEQVLTDYTVRKMHVKLVDSND
 | | .|.   .  ..||||||..||  ||| .. | .   |.|... .|. . ||..| | . ..  . | |.......... .  . | .....|| .
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

Q-PPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIF
. ..  .| | ...|.|.|||.  . . ..   .|.    .. |..||||||.||. .|.. ..  .. | .  |..   ....|..| . |||  |  .
kfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw

V
.
m
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 161-394 2.4e-32 106.8 In-house 57-287 (305) alignment 
Range on Protein: 161-394
Range on HMM: 57-287/305.0
LLNRFANIVVYDDNRITLRPMSghkdcTNEYINACYIN-DYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYG
  ||.... . | . . |   |       .|| | |.      . ..|..|||. .|. .|| .. |.|   |.|. . .| ||.|| |||| .  ..  
tknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

PFSVTLND-----EQVLTDYTVRKMHVKLVDSNDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQ
  |  . .       .  |  ..   ..|  | ||  . . . ..| ||| |||    . |..   |.     .| |..||||||.||||| .||.  |.
lksgivvenvsgskpmerdaeiqitllnltysgdq.kmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyile

Q-AEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
. ||.     .  ... .|.||   .|.  ||.|.   .|.
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 406-680 2.7e-32 106.6 In-house 14-286 (290) alignment 
Range on Protein: 406-680
Range on HMM: 14-286/290.0
FNRMNEPNTKTGQTGYEEQFTVLQQVTQRPDEVTHNIASQNK--DKNRSKQFLPPDNYRVPLK-GEHPDYINAAFINGYKekKAFIIAESPMFNTARNFW
|...    .| .  ..  ..    .     . .  .|  .|    ||| |.    |  || || | . ||. | ...| |    ||... .. .|. ..|
fekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiw

KMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPS-GMILGEYNIKLLSEETH-NGYIERKFEVKQTNTGATQSVTQYQITNWDSTGkLTNPQtiLLVIeE
.|. . .|.||||||   |. .  | ||.| .    . .||. .    |... .  | . . |.. ..|    .  ..|  |     ... .  | ..  
rmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks.valst..lall.r

MYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLDSF
. |. ||  .  .|||||  . |.  | |  ... .. ..|  .|. .. .. |  . .|||   || .. .|.| .  .|
tlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
0046846 (Phosphotyrosine protein) phosphatases II 462-678 2.7e-29 97.5 In-house 4-174 (176) alignment 
Range on Protein: 462-678
Range on HMM: 4-174/176.0
RVPLKGEHPDYINAAFINGYKekkaFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMIlgeynikllseethngyierkf
|..  ....||||| .| |..    .|.   |. .|  .|..|. . ..||.|.|. | | ..  |..|||   .  |                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

evkqtntgatqsvtQYQITNWDSTGKLTNpQTILLVIEEMYRTQRKrGnTSIVVHCSDTVSRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSV
              ||. ..|.  |  .  . .| ..|.... ... |   ..||||  ..|.....||      ...|  ..|...|.  | |.| |.|
..............qylhlpwpDhgvpdl.elllellefirealke.g.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTVQQYQVIFQIVLTYLD
|| .||. . . .| .|.
qtpeQyrflyefellllk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 161-318 2.9e-29 96.8 In-house 35-190 (297) alignment 
Range on Protein: 161-318
Range on HMM: 35-190/297.0
LLNRFANIVVYDDNRITLRPMSGHKDctneYINACYI--NDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNY
  ||. .|. .||.|. |.     .|    |||| |.   |  ....|| .|||.|.|. |||.|....   .|.|.... |.|. ||  |||... .. 
rknryrdilatddtrvkllrviterd....yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

GPFSVTLNDE-QVLTDY-TVRKMHVKLVDSNDQppLMITQYHFTSWPDHGVPEYATSILQFH
   .| ..   ..  .. .|    ..|.  ...   ...   | ||||||||     . .|.
kagdvvveflsstsdefdrviltelqliyrses..rvvrhvqflswpdhGvpsdledlvrfq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 160-398 3e-29 96.7 In-house 44-278 (312) alignment 
Range on Protein: 160-398
Range on HMM: 44-278/312.0
KLLNRFANIVVYDDNRITLrpmSGHkdcTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSdtKNYg
| |||. || ..|  |.||   .|     | || | ...  ..  ....||||. || . ||.|     |  ||... ..|.|  || .|  |     . 
kdlnrypniqcwdrgrftl...agd...enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi..vgf.

pfsVTLNDEQVLTDYTVR------------KMHVKL-VDSNDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTF
   | |.| .| |.|               .  .|. | .  |    . .| ..||||||.|.   . |..   .|..    | |.. |||||||||||.
...vdledhrvyteycteieiggkskdkithrvlkvvvkatgq.esklnhyqwaswpdhgmpdscdtalrllsavkkd....kkpviahcsagvgrtgtl

MAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTX
. |.  .    .    ..  .   .|..| . |..  ||...  .||| .  
aliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 446-674 5.2e-29 96.1 In-house 8-238 (239) alignment 
Range on Protein: 446-674
Range on HMM: 8-238/239.0
NKDKNRSKQFLPPDNYRVPLK----GEHPDYINAAFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMil
|| |||  . .  |  || |.      | |||||...  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| . |    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky..

GEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNpQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTE
 .  . |   |    || | | . |      . | ||..| |   |      | .| .      .   |    |.|||  | |.  |    . . ..| .
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVL
  .|.|. .|. | ..|  ||| .|| .|.  ||
ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 446-674 5.2e-29 96.1 In-house 7-237 (239) alignment 
Range on Protein: 446-674
Range on HMM: 7-237/239.0
NKDKNRSKQFLPPDNYRVPLK----GEHPDYINAAFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMil
|| |||  . .  |  || |.      | |||||...  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| . |    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky..

GEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNpQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTE
 .  . |   |    || | | . |      . | ||..| |   |      | .| .      .   |    |.|||  | |.  |    . . ..| .
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy.atavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVL
  .|.|. .|. | ..|  ||| .|| .|.  ||
ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 202-388 9.4e-29 95.0 In-house 3-196 (199) alignment 
Range on Protein: 202-388
Range on HMM: 3-196/199.0
NQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPD--SDTKNYGPFSVTLNDEQVLTDYTVRKMHvkLVDSNDQPP--LMITQY
 | .||||| |. .|. |||...|.  |  |.|. .   . ..    |||   | | .|| .||| .   .  |||.  .   |...   ||    |..|
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitali..ltnnttappstreishy

HFTSWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMKMVQTADQYIFV
 |||| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  .. . ..| |.
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 203-388 1.2e-28 94.7 In-house 3-195 (198) alignment 
Range on Protein: 203-388
Range on HMM: 3-195/198.0
QYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPD--SDTKNYGPFSVTLNDEQVLTDYTVRKMHvkLVDSNDQPP--LMITQYH
| .||||| |. .|| |||...|.  |  |.|. .   . ..    |||   | | .|| .||| .   .  |||.  .   |...   ||    |..| 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitali..ltnnttappstreishyq

FTSWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMKMVQTADQYIFV
|||| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  .. . ..| |.
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 431-666 1.2e-28 94.8 In-house 35-270 (301) alignment 
Range on Protein: 431-666
Range on HMM: 35-270/301.0
VTQRPDEVTHNIASQNKDKNRSKQF--LPPDNYRVPLKGEHpDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCY
 |   |..|.  |  .|||.| ..    |    .|  .|.    | | .|.   . . ||.. .|. ||. .|| |.   .|  ||||... |...|.| 
ttidkdhitesyaylpkdkhryptvPckPstavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekce

QYWPSTPS-GMILGEYNIKLLSEET--HNGYIERKFEVKQTN-TGATQSVTQYQITNWDSTGkltNPQTILLVIEEMYRTqrKRGNTSIVVHCSDTVSRS
.| |...|  . .| ..||. ..|.  ..  ..|..||. .    ||..|| || ..|   |    |..   . . |     |. .  ||||||. . ||
eylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrg...vPkshaelfdlmelv..kksekPivvhcsaGiGrs

AMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
  | ..    .. ...  |.. . ||  | ..  .|||..| 
vafigteylareveadptieltealkhlrehrwngvqtnsql
0043147 (Phosphotyrosine protein) phosphatases II 468-671 1.4e-28 95.2 In-house 3-155 (172) alignment 
Range on Protein: 468-671
Range on HMM: 3-155/172.0
EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEnennqevcyqywpstpsgmilgeynikllseethngyierkfevKQTN
|. ||||| ....|   . ||.   |. ||   ||.|. ....|.||.|. .                                              . 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

TGATQSVTQYQITNWDSTGKLtNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVQQY
.. .... ||. ..|.  |   ... .| ..| ... . .. .  ..||||  |.|.....||   .        . .......  | ..||.||. .||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqy

QVIFQ
. . .
rflyy
0048076 (Phosphotyrosine protein) phosphatases II 258-392 1.9e-28 94.3 In-house 13-139 (145) alignment 
Range on Protein: 258-392
Range on HMM: 13-139/145.0
YGPFSvTLNDEQVLTDYTVRKMhVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDMGLQqae
.|..  | .| . | |. ..   . | .  . .  ...||....|||||||. .  .|.| . |.. .|   ||.|||||||||||||..|... |.   
lgslp.taldlellkdlgittv.lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll...

keGGIDIISIINRMRQQRMKMVQTADQYIFVNDAV
   |... ......|.||...|.. .|..|. ...
..lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 425-674 2.4e-28 93.6 In-house 26-233 (392) alignment 
Range on Protein: 425-674
Range on HMM: 26-233/392.0
FTVLQQVTQRPDEVTHniASQNKDKNRSKQFLPPDNYRVPL----KGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEN
|  | .    |. |..     |. ||| |. || |. || |       . ||.||..|.... .||.| ...|   .  .||.|. . |||.|.|. . .
fhdlpgpdiypqtvaq..keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklk

ENNqevcyqywpstpsgmilgeynikllseethngyierkfevkqtNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMyrtQRKRGNTS--IVVHCS
| .                                           .   ...|.|...|.|   .      ..| .|.|.   . . |. .  ...|||
egd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcs

DTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVL
  | |...  .  . . ..|.  ..|||...   | ..|  ||| .|| .|.  ||
agvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 294-397 5.5e-28 92.5 In-house 91-195 (440) alignment 
Range on Protein: 294-397
Range on HMM: 91-195/440.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAV
. |||. .|||.|||..|  .|.. . ... . |  .||.|||||||.||||  .|.|  |..|..   |||.|.|| ||..| .|||| .|| ||..||
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

LESVT
||.. 
legll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 422-684 6.8e-28 92.5 In-house 19-286 (307) alignment 
Range on Protein: 422-684
Range on HMM: 19-286/307.0
EEQFTVLQQvtQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLK--GEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHE
 ..|.|| .  . |. || .  | | |||| ..    |. |. .|  |   ||| | ..    . | || |. |. ||  .|| |. . .| ...|||. 
vdefrvlak..ktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckv

NENNQEVCYQYWPSTPSG-MILGEYNI----KLLSEE---THNGYIErKFEVKQTNTGATQSVTQYQITNWDSTGkltNPQTILLVIEEMYRTQRKrgNT
 |  .  | ||||      .. || .     . |  .     . .|.   ..|   .. .......| .||   |    ||. |  |. .  .. .  . 
ielakikceqywpleegqklvfgeapntisvanlgakklapdedlin.vttlkvdwaqksrtiqhlqwenwpdrg...vpqinltainlleavryd..tn

SIVVHCSDTVSRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL-DSF-ETYS
 .|||||  | ||    | .   .|  . .   |. ....  | |.. ..||  ||  . ...| |. . . ||| 
pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketye
0049260 (Phosphotyrosine protein) phosphatases II 477-671 8.2e-28 92.4 In-house 1-144 (152) alignment 
Range on Protein: 477-671
Range on HMM: 1-144/152.0
FINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWpstpsgmilgeynikllseethngyierkfevkqtntgatqsvtQ
||.||. ...||... |. ||. .||.|. . ..|.||||. . |.. . |.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YQITNWDSTGKLTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVSRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQ
|. ..|.  |  ...| .| ... . .  ... .  ..||||  |.|.....||   .        ........  | ..||.|.. .|.. ...
ylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 209-388 1.2e-27 91.2 In-house 96-280 (302) alignment 
Range on Protein: 209-388
Range on HMM: 96-280/302.0
TQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDS--DTKNYGPFSVTLND-EQVLTDYTVRKM------HVKLVDSNDQPPLMITQYHF
   |  .||  .| || | .  |.. .....|... || .|. |   .. ..| ..|.  . .. | ..| .|        .|    ... .  .   .|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TSWPDHGVPEYATSILQFHRRIkNEYKptkGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFV
..||||| |. | . |.  .   . ||     .|||||||||||||..||  |.|   |.   |..||.  .|| |   ||...| |..
sawpdhGapkeaytaldilkfc.esyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
0049772 (Phosphotyrosine protein) phosphatases II 444-683 1.2e-27 92.9 In-house 44-286 (314) alignment 
Range on Protein: 444-683
Range on HMM: 44-286/314.0
SQNKDKNRSKQFLPPDnYRVPLKG---EHPDYINAAFINGYkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVM-------------
  |.||||....|| |  || |.|   .  ||||| ...|.   ..||... |. .|  .|          |.|.  .|.||  |||             
flnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------LCHENENNqevcyqywpstpsgmilgeY----------NikllseethngyierkfEVKQTNTGATQSVTQYQITNWDStGKLTNPQTILLV
        |.   .|.                              .                 |.   .   .. . .|  ....  |    .. .. .
daAlgKtpllildgng...................neptaadlellk.................eelydpelferlgikylripvpD.gsaplledfdef

IEEMYRTqrkRGNTSIVVHCSDTVSRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTVQQYQVIFQIVLTYLDSFETY
.| . .    . .. ..|||.. ..|.. |..||  . ..   || .. ..|.  | . |     |.... .||. |....| ||. ....
lefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
subfamily_CG42327_pd Subfamily CG42327 156-324 2e-27 90.7 In-house 27-193 (319) alignment 
Range on Protein: 156-324
Range on HMM: 27-193/319.0
TSSNKllNRFANIVVYDDNRITLRpMSGHKDcTNEYINACYINDYSN-QYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSD
|| .|  .|..|.|   . |..|.   | .|  .||..| |.  | . . .|||.| .  ..  ||||..|. .| .|. .|.. | |  .| .|.| ..
tskdk..srvinvvPlPetrvvlq.rigddd.kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke

T----KNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPlmITQYHFtSWPDHGVPEYATSILQFHRRIKNE
|    . || . ||| . .|   | .  . .| || .   .  .| | .  |.. .||   ....    .... 
tldntslyGdilvtlkgrevkdryaistlllkrvdkeesre..lthywy.kwleaevPaeeaaliamllevrss
0048179 (Phosphotyrosine protein) phosphatases II 279-389 2.1e-27 91.0 In-house 32-138 (144) alignment 
Range on Protein: 279-389
Range on HMM: 32-138/144.0
MHVKLVDSNDQPPLM--ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekEGGIDIISIINRMRQQRM
. . |... ... |   ..||....|||||||.... .|.| . |.. ..  .||.|||||||||||||..|... .     . |... ......|..|.
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrp

KMVQTADQYIFVN
 .|.. .|..|. 
gavpnpgqlrfLl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 407-676 3.8e-27 89.8 In-house 8-278 (439) alignment 
Range on Protein: 407-676
Range on HMM: 8-278/439.0
NRMNEPNTKTGQTGYEEQFTVLQQVtqRPD-EVTHNIASQ--NKDKNRSKQFLPPDNYRVPL----KGEHPDYINAAFINGYKEKKAFIIAESPMFNTAR
.   |   |  |  ..| |  .. .  .|| ..  ..|.|  .. ||| |.  . |  || |       |  |||| .|.|| ..| .| .. |  .|. 
qehvekldknkqeifkeifekinst..spdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

NFWKMIDDRNVTAIVMLCHENEnnqevCYQYWPSTpSGMILGEYNIKLLSEETHNGYIERKFEVK--QTNTGATQSVTQYQITNWDSTGKLTNPQTILLV
.||... ..... ||||.   |      |.||||  . .. |.  ..   .     |. | | |   . .|   ..| |.. . |      ..   .|  
dfwrlviekktvtivmltnlve.....sykywpsd.aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

IEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTY
.  .  .. |.    .|||||  | |.    |   .... |.|  .|.  ..|  | |.   ||.. || .|.. ||  
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 169-427 1.1e-25 85.3 In-house 28-285 (290) alignment 
Range on Protein: 169-427
Range on HMM: 28-285/290.0
VVYDDNRITLRPMsgHKDCTNEYINACYINdYSNQYQYIATQGPVSN-------TLVDFWRLIWQEKSPIIIMITNVIEEGKV----KCQQYWPDSDT--
 .  ..|. |.     |  ...|| | ..  ..|  . |.|| |  .       |. .|| .. |||.  ..|. .. |. .      |..| |.|    
pLveatrvvLkgy..gkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee

KNYGPFSVTLNDEQVLTDYTVRKMHVKLvdsNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQ
 ... ..|   .     |  .|.. ||    .|. .. .| . . .| .  |.|   ..|.  . .|..    | |..|||  |. |  .. ||..| | 
lkfkgltvkCkskekeddvetRelvvkf...ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQk

AE-KEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLesvtxxXXARIVFNRMNEPNTK-TGQTGYEEQFTV
   ..| . . .... .|.|| .....| .. ||  ...        |  | ... |..|.   .....| .. 
iaetsgsvkledvlkalrkqralaitsalelafvdagiv......llaievldqfaeeetekkakaeeketykk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 444-676 4.4e-25 82.9 In-house 35-268 (281) alignment 
Range on Protein: 444-676
Range on HMM: 35-268/281.0
SQNKDKNRSKQFLPPDNYRVPLKG-----EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGM
  |. |||  .    |  || ||      .  ||| | .|     |. .|... |  .|  .||.|| . | |||||||.  | |.| | .|.|      
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

I-LGEYNIKLLSEETHNGYIERKfeVKQTNTGATQSVTQYQITNWDSTgKLTNPQTILLVIeemYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKC
. . .. ..       .  .  .  .. .  | |. .|..   .|    .. .   ..| |    |  | |  |  |.|||  | ||  . |   ...  
lqfdklsvsyedstvnkslvttr..lnlsyegetrlithwlwkewpdw.qvpessevmlki...lrkirar.stppvihcsagvgrsgtlmaveialqsi

KTEG-VIDVFQVLKSQRIQ-KPGSVQTVQQYQVIFQIVLTY
..   . |. |..   |.  .  ||||.||| .|....| .
hshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 421-678 6.9e-25 82.4 In-house 24-288 (305) alignment 
Range on Protein: 421-678
Range on HMM: 24-288/305.0
YEEQFTVLQQVTQRpDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEHP-DYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHE
  ..|. .... .  . .     .|...||| |.    || || |.|  | .|| | ..    . | || ...|. .|  .|| |  . .| || |||  
lraefvamkrfndf.ekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnl

NENNQEVCYQYWPSTPSG-MILGEYN----IKLLSEETHNGYIERKFEVKQTN------TGATQSVTQYQITNWDSTGKLTNPQTillVIEEMYRTQRKR
 |   . |..|..|     . . | .    .|. | .| .   . | .|..|        . .. ||.|   .|   |  .  ..   ..| . ...  .
lekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadla...ilellekarpsk

GntSIVVHCSDTVSRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYLD
|   ||||||  . |.         ...  .  .|.   ..|.  | |.  |.|| .||  . |..| |. 
g..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_egg_pd Subfamily egg 136-393 9.4e-25 81.9 In-house 17-267 (307) alignment 
Range on Protein: 136-393
Range on HMM: 17-267/307.0
RNQFGMLDSGESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLRPMSGHkdCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMI
  .. .|.    | ..|  ... |.   |   .   |  |..|.   |    ....| | ...      ..| .| |. ||  ||||...||. . |.|.
errlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGq..ylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivml

TNVIEEgkVKCQQYWPDSDT--KNY--GPFSVTLNDEQVLTDYTVRKMHVKLVDSNdqpplmITQYHFTSWP-DHGVPEYATSILQFHRRIKNEYKptkg
|   |    .|. ||| ...    .  | . ..  . .  .|   |  ..||| ..        . .   |  |        | |.  |...|  |    
tsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd......deerflehwqgdvnnssdvysplrvlrklrnlsk....

PMLVHCSAGVGRTGTFMAIDMGLQQAEKEgGI---DIISIINRMRQQRMKMVQTADQYIFVNDAVL
|..|..  || ...|..||.. | .  .   |    .   .  .|..|   |... .|.||   ||
pvvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvl
0051082 (Phosphotyrosine protein) phosphatases II 469-672 2.7e-23 77.7 In-house 2-148 (151) alignment 
Range on Protein: 469-672
Range on HMM: 2-148/151.0
HPDYINAAFINGYkekkaFIIAESPmfntARNFWKMIDDRNVTAIVMLCHENENNqeVCYQYWPSTPsgmilgeynikllseethngyierkfevkqtnt
..||||. .. |.     ...   |       |.... . ....||.|. | |..   |..|.|..                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

gatQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRtqrkRGNTSIVVHCSDTVSRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVQQYQV
     |....|..|. .|  ......| ..|.. .     .|  ..||||  ..|.....|.   . .      ......|.  |.. ||.||. ||...
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

IFQI
... 
qlfa
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 146-257 3.5e-23 76.9 In-house 36-157 (350) alignment 
Range on Protein: 146-257
Range on HMM: 36-157/350.0
ESEHTVTVGLTSSNKllNRFANIVVYDDNRITLR----P--MSGHKDCTNEYINACYIN------DYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIII
  .  .. |. .  |  ||. ||. |. .|. |.    .     |   ||.|||| |..      .   ...|||||.|. .|. ||...| . | ..|.
snDvilseGvelfak..nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvil

MITNVIEEGKVKCQQYWPDSDTKN
..|. .| .  ||..||.. . ..
sltsdvelnlekcyrYWqegsydd
subfamily_egg_pd Subfamily egg 420-677 4.1e-23 76.5 In-house 15-270 (307) alignment 
Range on Protein: 420-677
Range on HMM: 15-270/307.0
GYEEQFTVLQQVTQRpDEVTHNIASQNKDKNRSKQFLPPDNYRVPLK---GEH-PDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVM
..| .. ||......   .|. ... |..| |||.    |  || |.   | .  |.| |  ..|      ||.|..|. ||  .||.|.   .|  |||
elerrlevleesvde.islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

LCHENENnqEVCYQYWPSTPSGM---ILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILlvieemyRTQRKRgNTS
|    |.  | |  ||| ..|     . | ..|. |  . .   . |  ..|   .   .   ..   ... ....  |  .|       |  |.   . 
ltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvl.......rklrnl.skp

IVVHCSDTVSRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVQQYQVIFQIVLTYL
.||.. . ||..| . |. ... .    | |  . ||..    | ... ||..| .|  ....|| ..
vvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_ptpA1_pd Subfamily ptpA1 422-636 7.8e-23 75.9 In-house 24-255 (418) alignment 
Range on Protein: 422-636
Range on HMM: 24-255/418.0
EEQFTVLQQVtQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKG----EHPDYINAAFINGYKEkKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
.|.| .|..    | | .     .|  |||  . || .  || ||     |  ||||| .|.|    | || .. |. ||  .||.|. .  .  |||| 
keefrllees.vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmls

HENENNQEVCYQYWPSTPSG----------MILGEYNIKLLS--EETHNGYIERkfEVKQTNTGATQSVTQYQITNWDSTG--KLTNPQTILLviEEMYR
.|.|| .  | .|||    |           ..| |...|.   ..     | |  ... |  | |. .||||   |        |.|   ||    .  
resencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitr..nirltfegetrditqyqyegwpdhnipdhtqpfrqll..hsitn

TQ-----RKRGNTSIVVHCSDTVSRSAMFCAAATTINK
 |         |  |.||||  | |.  ||.|   ..|
rqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk
0044763 (Phosphotyrosine protein) phosphatases II 468-674 2.1e-22 75.1 In-house 16-168 (178) alignment 
Range on Protein: 468-674
Range on HMM: 16-168/178.0
EHPDYINAAFINGYkekkaFIIAESPMfntaRNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSgmilgeynikllseethngyierkfevkqtn
|  ||||| .| ..     ....  |.     ...... . ..|.||.|..| |.... |..|||.  .                               
ersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...............................

tgatqsvTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVSRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVQQYQ
        ||. ....  |  . .. .| ..| . . .  . .  ..||||  |.||....||   .      |. .......  | ..|  |..  |..
.......iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlr

VIFQIVL
 . .. |
qLyefel
PTPc_DSPc_SM00012 574-674 2.4e-22 74.5 In-house 2-104 (105) alignment 
Range on Protein: 574-674
Range on HMM: 2-104/105.0
VTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRG-NTSIVVHCSDTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQ
|..|..|.|  .|. .... || ..... . ..|.. ....|||||. |.|...|.|... ......| . .|.||..|. | |.||.||| .||... .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IVL
..|
all
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 445-677 9.1e-22 72.4 In-house 42-271 (288) alignment 
Range on Protein: 445-677
Range on HMM: 42-271/288.0
QNKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMI-LGEY
.|  ..| ..    |  || |. .   ||.|  .   | |. .| |..|.  |  ..|||. . .|  |||||.  |  .|   .|.||     . .| .
anptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

nIKLLSEEThnGYIERKFE---VKQTNTGATQS-VTQYQITNWDSTGKLTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKT
  .   ..     |..  .   .. ...| ..  | .  . .||  |   | .. | ..| .     |  .  ||||.|  | |.. .      ..  . 
.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrl

EGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
.  . . ..|.. | ..  ..|| .||  ....|| .|
ddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 159-389 1.1e-21 71.6 In-house 51-278 (302) alignment 
Range on Protein: 159-389
Range on HMM: 51-278/302.0
NKLLNRFANIVVYDDNRITLrpmsghKDCTNEYINACYINDYSNQYQYIATQGPVSNTL---VDFWRLIWQEKSPIIIMITNVIEEGKvKCQQYWP--DS
|   |.  .. ..|.|.. |      . . ..|.||  ..  . ... | .| |....     .|||...|||   . ..    |  |   ....|    
nlkknqsedvpildsnlvkl......eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

DTKNYGPFSVtlNDEQVL--TDYTvRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDM
| |.|| . |  |  .|    . .  .  . ..  .    .... |..| |... ||.  ... .    . ..  ... ....    |.|| |.|..  .
dykeygkmfv..NnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlav

GLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVN
 ... .|.    |  |.. .|.|| ..|....||... 
aveklqkgkepnikeivksiRsqRpravdslkQyvsly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 462-677 2.1e-21 71.3 In-house 34-259 (290) alignment 
Range on Protein: 462-677
Range on HMM: 34-259/290.0
RVPLKGE----HPDYINAAFINgYKEKKAFIIAESPMFNT-------ARNFWKMIDDRNVTAIVMLCHENENNQE----VCYQYWPSTPS-GMILGEYNI
||.|||       ||| | ..  . .  ..|. .||  ..         .|| |. . .|. .||||  .|....     | .| | .    . ..  ..
rvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltv

KLLSEETHNGYIERKFEVKQTNtGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVSRSAMFCAAATTINKCK-TEGVID
|  | |.... ..|. .||  . .    || ... .|...    ...|.| .|. .     |  .| ..||| | .||||.. |      |   |.| . 
kCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvk

VFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
. .|||. | |.   ... ...  .   .. ..
ledvlkalrkqralaitsalelafvdagivlla
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 208-394 5.9e-21 69.7 In-house 39-219 (255) alignment 
Range on Protein: 208-394
Range on HMM: 39-219/255.0
AtqgpvsnTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGV
        |.  |.. | | |.  ..|...  |||..||..|.|    .      |..   .  .|  .| ... .  .. .    .. |... |...  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PEYATSILQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
|| |  ||.  . ...  |    ...||||.|.||. .|. ...  |      .  . ...| .|... .|..| . ..|  |  |    ||.
Pelareilnilkvvrds.k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 435-677 1.1e-20 68.8 In-house 24-270 (285) alignment 
Range on Protein: 435-677
Range on HMM: 24-270/285.0
PDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFIN-GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPS
| ..|.     | | ||  .    .. || ||    ||| |...    |.. ..| .. |. .|  .||.|| . ... ..|||   |   | |  |.| 
ppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

TPSGM-ILGEYNIKLL--SEETHNGYIERKFEVKQTNTGATQSV--TQYQITNWDStgKLTnPQTILLVIeEMYRTQRK--RGNTSIVVHCSDTVSRSAM
    .  .|.|.| |    ||.  | |   . | .|.  ... .   . |.  |    .|. |.    .| |.|.  .|    .. |.||||  | |.| 
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpd..qla.pedarpmi.elykwvkkvnpkekpicvhcsagvgrtat

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
|     .  .   .  |.......  |  .  .||.  |. ... ... |.
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 443-677 3.5e-20 66.8 In-house 52-289 (305) alignment 
Range on Protein: 443-677
Range on HMM: 52-289/305.0
ASQNKDKNRSKQFLPPDNYRVPLKGEHP-DYINAAFING-YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGmIL
|  .. ||| ..    |.  | |.   | ||| | ..      .| || |. |. .|  .|| |. ...|  |||||.  |  .  | |||| .     |
adiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge.kl

GEYNIKLLSEETHNGYIERKFEVKQTN------TGATQSVTQYQITNWDSTGKltnPQTILLVIEEMyRTQRkRGNTSIVVHCSDTVSRSAMFCAAATTI
   .  .. . . .  .||  |.. |        . . || . | |.|   |    |   |  .| .  . |   .  ||||||  . |.    |    .
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv...ppckltslell.sair.gskvpivvhcsagigrtgtivaieyil

NKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
.|   .  .  . ...|. | |.  |.|.  ||  | ...| |.
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_CG42327_pd Subfamily CG42327 423-600 4.9e-20 66.4 In-house 9-189 (319) alignment 
Range on Protein: 423-600
Range on HMM: 9-189/319.0
EQFTVLQQVTQRPDEVThniaSQNKDKNRSKQF--LPPDNYRVPLKGEHP--DYINAAFINGYKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIVMLC
|.|  | |.  | |||        |||.|  .   ||. .  .. .|...   |..|... ||.. .. .| |. .. ... .||... ...   || |.
eefrdlPqliaradevP....vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

HENENNQEVCYQYWPST---PSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQItNWDSTGKLTNPQTILLVIEE
   |.  .|| .|.|.    ..    |.. . |   |... |.   . .|. .   .. .| |   .|  ..  ....... .. |
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamlle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 415-676 1.6e-19 64.6 In-house 23-289 (310) alignment 
Range on Protein: 415-676
Range on HMM: 23-289/310.0
KTGQTGYEEQFTVLQqvTQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLK---GEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
| |  |   |.  |.  ...   .|..   ..  |||  . .  |. || ||     . ||| | ...    ...|| .. |.  |  .||.|| .    
klgieglvkqyrkld..akqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqerae

AIVMLCHENENNQEVCYQYWPSTPSGMILGEYNIKLLSEETHNGYI---ERKF---EVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQ
.|..||.  |. .  |  ||||       |   .  ||| ...  |      |   .|   .  |     . .. .|        |.     . .   .|
silllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaq

RKRGNtsIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTY
 . |    |||||  . |  . .|   .|.| .    .|. .|    . ..   .||  || .| .. . .
vrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 279-393 1.6e-18 61.6 In-house 205-341 (350) alignment 
Range on Protein: 279-393
Range on HMM: 205-341/350.0
MHVKLVDSNdqpPLMITQYHFTSWPDHGVPEYATSILQFHR--------RI-KNEYKPT-KGPMLVHCSAGVGRTGTFMAIDMGLQQ------A-EK---
. ..|  |.   |... | ..  |.| ..     ||||            . .. ..     |.|||||||||||||....|. |..        ..   
taitlaasd...PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrk

----EGGIDII-SIINRMRQQRMKMVQTADQYIFVNDAVL
        |.|  |.|..|.||..|||. ||.||. .|.|
ldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 441-677 7.1e-18 59.0 In-house 46-285 (302) alignment 
Range on Protein: 441-677
Range on HMM: 46-285/302.0
NIASQNKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFINGYKEKKAFIIAESPMFNTA---RNFWKMIDDRNVTAIVMLCHENENNQeVCYQYWPST-PS
..  .| .||.|...  .|. .| |..|  .|.||. ..  . ..  |.|  |  ...    .||.|. ..... .|.|  |.| ..    ...| .  .
kafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

GMILGEY--NIKLlSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVSRSAMFCAAATTI
    |.   |..   |....   .   ||   .   .  .. | .||| ..  ...  ..   .....  .   .. ..|.     . | ..| ..|...
ykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakk.ikadentvivSknGaGRagafltlavav

NKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
.| ...    . ...|| | |.| .|....||  .. ..|.|.
eklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_hpo-7_pd Subfamily hpo-7 213-394 7.9e-18 59.3 In-house 43-225 (263) alignment 
Range on Protein: 213-394
Range on HMM: 43-225/263.0
VSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPDSDTKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMITQYHFTSWPDHGVPEYAT
. .|.  |.. | | |.  ..|...  |||..||..|.|    .      |..   .|  |  ..  ..  . .. .    ...| .. |...  || | 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

SILQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLE
.||.  .  .|  |    .. ||||.|.||.  |  ...  |      .  . ...| .|... .|..| . ..|  |  |    ||.
eilnilkvarns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 482-672 4.7e-17 56.8 In-house 2-199 (199) alignment 
Range on Protein: 482-672
Range on HMM: 2-199/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMI-LGEYNIKLLSEETHNGYIERKF--EVKQTNTGATQSVTQYQ
| .. .| .. |. .|  .||.|. .     |||.  .. |..     |||.| ||    |  ..   .  |.  |    .    . |   .|. ...||
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

ITNWDST--GKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQI
.| |      ...    ...   |. .   .  .. ..|||||    . .| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.|.
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 483-672 6e-17 56.5 In-house 2-198 (198) alignment 
Range on Protein: 483-672
Range on HMM: 2-198/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMI-LGEYNIKLLSEETHNGYIERKF--EVKQTNTGATQSVTQYQI
 .. .| .. |. .|  .||.|. .     |||.  .. |..     |||.| ||    |  ..   .  |.  |    .    . |   .|. ...||.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWDST--GKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQI
| |      ...    ...   |. .   .  .. ..|||||    . .| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.|.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 446-683 8.8e-17 55.7 In-house 43-282 (312) alignment 
Range on Protein: 446-683
Range on HMM: 43-282/312.0
NKDKNRSKQFLPPDNYRVPLKGEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGMILGEYNI
 || ||  .    |  |  | |.   || | |..     . |.....|. ||. .||..      |.|..||   |.  | | .|     . . | .. .
fkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

------KL-LSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVSRSAMFCAAA---TTIN
      .. .   ...    | . |    ||    . .|| . |   |     .| | ..  .     |. .  .. |||  | |.  ..      ... 
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalr

KCKTEGVIDVFQVLKSQRIQkpgSVQTVQQYQVIFQIVLTYLDSFETY
. . . | |.| .|. .| .   ||... ||   ...|| .| |   |
hprkqnvkdsfvllrkdrar...svrvfpqyvyalrcvleflyskgly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 443-554 1.1e-16 55.6 In-house 30-146 (297) alignment 
Range on Protein: 443-554
Range on HMM: 30-146/297.0
ASQNKDKNRSKQFLPPDNYRVPLKGEHP--DYINAAFINGYKEKK--AFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSG-
 .    ||| .. |  |. || |..  .  ||||| ..   .|..   .|.|. |. .|  .||... ...| .|||... .|. .. |. ||||.  . 
rnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

MILGEYNIKLLSEETHN
.  |.. .. ||. . .
lkagdvvveflsstsde
subfamily_CG42327_pd Subfamily CG42327 326-390 1.9e-16 54.6 In-house 244-309 (319) alignment 
Range on Protein: 326-390
Range on HMM: 244-309/319.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMKMVQTADQYIFVND
.  .||. |||| ||||||. .| |. ... |.    .||  ..  .|..| . |.| .|| |.  
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 430-594 2.9e-16 53.8 In-house 78-242 (244) alignment 
Range on Protein: 430-594
Range on HMM: 78-242/244.0
QVTQRPDE--VTHNIASQNKDKNRSKQFLPPDNYRVPLK-GEH-PDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQe
|   |||   .   .  .|  |||    || |  ||||  |     ||||.|.        .|... |. .|. .||||. .| |  .|.|   .|... 
qniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.

vcyqYWP-STPSGMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTI
    ||| | |      .  . |   .        ..|..     . |..| .||.|| | |   |   |
....ywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpndhfi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 158-405 4.3e-16 53.4 In-house 46-288 (303) alignment 
Range on Protein: 158-405
Range on HMM: 46-288/303.0
SNKLLNRFANIVVYDDNRITLrpmsghkdCTNEYINACYInDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWPD-SDTK
.|   |||..... |  .. |        .   || | |. .   . . | || |.| |  |||..| ..|   ....    |  |.  .  .|   |  
knmdknrfvdvicldhskvkl........sdssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

NYGPFSVTLNDEQVLTDYTVRKMHVKLVdSNDQPPLMITQYHFTSWPDHGVPEY-----ATSILQFHRRIKnEYKPTKGPMLVHCsAGVGRTGTFMAIDM
..   |. . . . .      ...|  | || .   ..  .|. .||   .|          | |    ..  | ... .. .   .|.||.|||  .. 
kfeersirvgefkrvelgdgwvlkvlsv.sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlr.kysdstptvymsl.sgcgragtfalfet

G-LQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESVTXXXXARIV
  |   ...  .|..  .. .|. |.. ||   |. .|   . | |     ....
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickla
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 456-677 1.5e-15 51.9 In-house 39-221 (255) alignment 
Range on Protein: 456-677
Range on HMM: 39-221/255.0
LppdnyrvplkgehpdyinaafingykekkafiiaespmfnTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGM-ILGeyNIKLLSEETHN
|                                        |  .|...|   . . .||||  .|...| | .|.|    .  .|   .... . .. .
l........................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla..dvnvtttkssa

GYIERKFEVKQTNT--GATQSVTQYQITNWDSTGKLTNPQTILLVieemYRTQRKRgnTSIVVHCSDTVSRSAMFCAAATTIN-------KCKTeGVIDV
  . |  |.  | .    |. |. |. . |       ... || .    ..  |.    |.|||||  . ||| |  |            . .| . .| 
dvvlrtleitstlgekkkthtvkhysykGWieknaPelareilni....lkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldy

FQVLKSQRIQKPGSVQTVQQYQVIFQIVLTYL
 ..|.  | .......|  |    . .||...
lslleelrskrkraihtPlqlafsilmvldlv
I-set Immunoglobulin I-set domain 6-92 6.3e-15 46.7 Pfam-A 1-90 (90) alignment 
Range on Protein: 6-92
Range on HMM: 1-90/90.0
PVIEEFPSNMTTEEGREILLKVKVKETPKLSFNWYHNGEPVTDDYAHELRGDG---SLLLVSVEEKHKGTYCFVANNDAGTVSQQVVLTV
|.... .......|| .. |...|...|..|..|...|.... .  .... ..   .| . .||.. .|.|  .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
0048076 (Phosphotyrosine protein) phosphatases II 537-675 1.5e-14 49.4 In-house 10-141 (145) alignment 
Range on Protein: 537-675
Range on HMM: 10-141/145.0
GMILGEYNIKLLSEETHNGYIERKFEVKQTNTGATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKrgNTSIVVHCSDTVSRSAMFCAAATTINk
|. || .   |  |. ..  | . . .  . .. .. ..||. ..|.  |  . ....| ..| . . ...  .  ..||||  |.|.....||   .  
glylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll.

cktEGvIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLT
   .| ......|.  | | ||.|....|.. ... .| 
...lg.vsleealelvrsqrpgavpnpgqlrflyefele
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 332-396 1.9e-14 47.8 In-house 1-65 (69) alignment 
Range on Protein: 332-396
Range on HMM: 1-65/69.0
MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
|.||||.| ||||||.|| . . .   |  .||   .. ||. |  ||    .|||. ||. |..
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_hpo-7_pd Subfamily hpo-7 489-676 2.4e-14 47.9 In-house 42-226 (263) alignment 
Range on Protein: 489-676
Range on HMM: 42-226/263.0
IaespMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGM-ILGeyNIKLLSEETHNGYIERKFEVKQ--TNTGATQSVTQYQITNWDST
.    . .|  .|...|   . . .||||  ||...| | .|.|    .  .|   |... . .. .  . .  |. .   .   |. |..|. . |  .
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla..nvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiek

GKLTNPQTILLVIeemyRTQRKRgnTSIVVHCSDTVSRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTY
   .... || ..    .  |.    |.|||||  . ||| |  | .          . .| . .|  ..|.  | .......|  |    . .||..
ndpelareilnil....kvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 489-671 3.1e-14 47.1 In-house 95-282 (302) alignment 
Range on Protein: 489-671
Range on HMM: 95-282/302.0
IAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSG-MILGEYNIKLLSEETH-NGYIERK----FEV----KQTNTGATQSVTQYQ
    |  .|   .| .|.. ||. .| ||.  |.... | .|.     | . .|.| .| .| .|. . . ..|    . |    .....   ..|   .
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

ITNWDSTGKLTNPQTILLVIEemYRTQRKrgnTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQ
 . |   |   ...| | ..   .    |   ....||||  | |.  . |    |. |... | |. ....  |  . |.||. ||   .. 
fsawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll
0048179 (Phosphotyrosine protein) phosphatases II 503-671 3.6e-14 48.2 In-house 23-139 (144) alignment 
Range on Protein: 503-671
Range on HMM: 23-139/144.0
KMIDDRNVTAIVMLCHENENNQEVCYqywpstpsgmilgeynikllseethngyierkfevkqtntgatqsVTQYQITNWDSTGKLTNPQTILLVIEEMY
... . ..|... |..| |.. . ..                                             ..||. ..|.  |  . .. .| ..| . 
ellkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefie

RTQRkrGNTSIVVHCSDTVSRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVQQYQVIFQ
. ..   .  ..||||  |.|.....||   .    ..| ......|.  | . ||.|.. .|.. . .
eale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 326-396 5e-14 46.8 In-house 225-295 (297) alignment 
Range on Protein: 326-396
Range on HMM: 225-295/297.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
.| . ..||||||||||.|  .  |. |..  |.   |. .|.. .|.|| ..||| .|. .. ||||. .
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 147-265 6e-14 46.1 In-house 38-165 (349) alignment 
Range on Protein: 147-265
Range on HMM: 38-165/349.0
SEHTVTVGLTSSNKllNRFANIVVYDDNRITLR----PMSGHKD-------C-TNEYINACYI--NDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPII
 .  .. |. .  |  ||. .|. |.  |. |.    .  . |        .  ..|||| |.    .| . .||||| |.  |. ||...|  .. ...
ddvilseGvelfak..nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklv

IMITNVIEEGKVKCQQYWPDSdtkNYGPFSVTL
. ...  |..  ||..|| .    .|  . | |
lsLnddkelslekcdiywqel...sysnitvkl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 334-396 8.5e-14 45.7 In-house 2-64 (69) alignment 
Range on Protein: 334-396
Range on HMM: 2-64/69.0
VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFVNDAVLESV
||||.| ||||||.|| . . .   |  .||   .. ||. |  ||   ..|.|. ||. |..
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 570-677 1.6e-13 44.8 In-house 87-194 (440) alignment 
Range on Protein: 570-677
Range on HMM: 87-194/440.0
ATQSVTQYQITNWDSTGKLTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVI
 .... ||.   |   |       .| .|...  .| | ||  ..||||  ..|...  |  . . ..|    ||.| ...| | ..|  ||| .|| ..
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

FQIVLTYL
.. ||  |
heavlegl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 437-535 2.7e-13 44.4 In-house 40-154 (350) alignment 
Range on Protein: 437-535
Range on HMM: 40-154/350.0
EVTHNIasQNKDKNRSKQFLPPDNYRVPLK------------GEHPDYINAAFINGY----KEKKAF--IIAESPMFNTARNFWKMIDDRNVTAIVMLCH
.... .  .   ||| |. || .  || ||             .  ||||| ...      . .  |  | . .|. .|  .|.|.|   .|. |..|  
ilseGv..elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

ENENNQEVCYQYWPSTP
. |.| | ||.||.   
dvelnlekcyrYWqegs
subfamily_eak_pd Subfamily eak 152-320 5.2e-13 43.1 In-house 45-206 (332) alignment 
Range on Protein: 152-320
Range on HMM: 45-206/332.0
TVGLTSSNKLLNrFANIVVYDDNRITLRPMSGHKDctnEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEGKVKCQQYWP
...    .   |   .|| || . . | .    ..    ||||  ..      .|| |  .  . .  ||... ..||| |... . .|..  | ..|.|
setarleavnrn.vvkivpydrylvrltssqlnrl...GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp

DSD--TKNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQpplmITQYHFTSWPDHGVPEYAtSILQFHRR
|      ..| . |.  .      . .|.. ..  .   .    .  |..  | .  .| |    | ... 
dktreelkfGildverkefvkrniletrllelskGnethr....vlhykvfGwtettlpkye.dflalrkv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 289-394 8.4e-13 42.3 In-house 215-342 (349) alignment 
Range on Protein: 289-394
Range on HMM: 215-342/349.0
QPPLMITQYHFTSWPDHGVPEYATSILQFHRrIKNE----------YK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQ---QAEKE--------GGIDIIS
. | .. |  .  |.| ..     ||||    .||.          ..     ..||||||| ||||... .|. |.     ..|           |.||
ekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

-IINRMRQQRMKMVQTADQYIFVNDAVLE
 |.| .|.||. |||   |.|.. .|.|.
iivnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 157-306 8.5e-13 42.5 In-house 94-234 (244) alignment 
Range on Protein: 157-306
Range on HMM: 94-234/244.0
SSNKLLNRFANIVVYDDNRITLRpmsgHKDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEgkvkcQQYWPDSDTK
 .|   || .  . .| ||. |     .    | |||| ..       .|| || |...| .|||... . .  .....  | ||     ..|||||.  
pnnswknregaglpfdfnrvpls....kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdsepl

NYG--PFSVTLNDEQVLTDYTVRKMHVKlVDSNDQpPLMITQYHFTSWPDHG
..     .||| | . . .    .. ..  | |.     .| .  . ||  |
ewyeeditvtltdrdefknikasnleie.sdmnes.hqaltmfqisnwpsdg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 469-589 3.8e-12 40.6 In-house 12-128 (130) alignment 
Range on Protein: 469-589
Range on HMM: 12-128/130.0
HPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQevcyqYWPSTPSgMILGEYNIKL-LSEETHNGYIER-KFEVKQT
  .|||| |.      . .. .. |. .|. .||||. .| |  .|.|   .|...     ||| .   .   | .| . |..     .|.  ..|... 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdseP.lewyeediivtltdrdefknikasnleiesd

NTGATQSVTQYQITNWDSTGKLT
   . |..| .||.|| | |   
lneshqaltmfqisnwpsdgttp
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 115-211 1.4e-11 38.5 In-house 5-95 (95) alignment 
Range on Protein: 115-211
Range on HMM: 5-95/95.0
IPVDKFGEFVAKGHAKGNKGFRNQFGMLDSgESEHTVTVGLTSSNKLLNRFANIVVYDDNRITLrpmSGHKDctNEYINACYINDYSNQYQYIATQG
| |  |   | . |.. .. | |.|  .    |  . ||| . .|   ||| ||. ||  |..|   . ..|   .|||||... |. .  |||.||
ihvsvfhshvlemhsnsdqefdnefksism.tsgapytvgsseanipknrflnifpydatrvvl...ttkrd..sdyinacfvdgyarkncyiaaqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 199-283 1.2e-10 35.4 In-house 231-313 (440) alignment 
Range on Protein: 199-283
Range on HMM: 231-313/440.0
DYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEgkvKCQQYWPD-SDTKNYGPFSVTLNDEQVLTDYTVRKMHVKL
 ||..  .|||| |.  |..|||||. . .   |||. .. .     |  |||  . .  .|||.|  .  . .    || . .| 
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelky
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 431-673 3.4e-10 34.0 In-house 32-275 (303) alignment 
Range on Protein: 431-673
Range on HMM: 32-275/303.0
VTQRPDEVTHNIASQNKDKNRSKQFLPPDNYRVPLKgeHPDYINAAFINGYKEKKAfIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQY
|.  | .|..|   .| ||||  . .  |  .| |      || |....   .||| |... |.  || .||.|| ...|  ...|  ..| ..      
vsylppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv

WPSTPSGMILGEYNIKLL---SEETHNGYIERKFEVKQTNTGATQSVTQYQitNWDSTGKLTN--PQtILLVIEEMYRTQRKRGNTSIVVHCS-DTVSRS
.|     . . |  |..      |  .|.  .   | . .  .   | .|.  .|  .   ..  |. ..  | ..    ||  ...  |. |   . |.
fprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgspk.fvkqiwqlqsvlrkysdstptvymslsgcgra

AMFCAAATTINK-CKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIV
  |.   |.     . .  .|. ..|.  |  .  .|| . |. |.. ..
gtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 600-676 4e-10 34.0 In-house 219-294 (297) alignment 
Range on Protein: 600-676
Range on HMM: 219-294/297.0
EMYRTQRKRgNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTY
| .|..  | |. ..||||  | || .   . . ..| . . . ||  .|.  | |..  |||..|.......||  
eslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 479-564 8.5e-10 32.5 In-house 230-312 (440) alignment 
Range on Protein: 479-564
Range on HMM: 230-312/440.0
NGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLcheNENNQEVCYQYWPSTPSGMILGEYNIKLLSEETHNGYIERKFEVK
.||  |.||| .. |.  |  .||... | ....|.||   |. |.  |  |||     . .| . .     |  |    | .|.|
egyskknafiatqmpldstvldfwrlvhdyristiiml...nqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 162-241 1.8e-09 31.6 In-house 40-122 (347) alignment 
Range on Protein: 162-241
Range on HMM: 40-122/347.0
LNRFANIVVYDDNRITLRPMS---GHKDCTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEE
 ||  .  . |. |. | |     .. | .. |||| .|.    . .|| || |. .|. |||...   |   .. | . |..
knrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 172-305 3e-09 31.3 In-house 6-124 (130) alignment 
Range on Protein: 172-305
Range on HMM: 6-124/130.0
DDNRITlrpmsghkdcTNEYINACYINDYSNQYQYIATQGPVSNTLVDFWRLIWQEKSPIIIMITNVIEEgkvkcQQYWPDSDTKNYGP--FSVTLNDEQ
. .|.            |.|||| ..    .  .|. || |...| .|||... .    .....  | ||     ..|||||.  ..      ||| | .
evsrlq..........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrd

VLTDytVRKMHVKLVDSNDQPPLMITQYHFTSWPDH
      ..  ...  .   .    .| .. . ||  
efkn..ikasnleiesdlneshqaltmfqisnwpsd
subfamily_eak_pd Subfamily eak 453-586 3.5e-09 30.5 In-house 58-193 (332) alignment 
Range on Protein: 453-586
Range on HMM: 58-193/332.0
KQFLPPDNYRVPLKG---EHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTP-SGMILGEYNIKLL
 . .| | | | |     ..  ||||. ..  .  . .|..  .  .    ||.|. ...  |||.| .. |.. |   .|.|      .  | ....  
vkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverk

SEETHNGYIERKFEVKQTNTgaTQSVTQYQITNWDSTG
.   .| .  |..|... |   |  |  |..  |  | 
efvkrniletrllelskGne..thrvlhykvfGwtett
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 444-565 4.3e-09 30.3 In-house 32-157 (332) alignment 
Range on Protein: 444-565
Range on HMM: 32-157/332.0
SQNKDKNRSKQFLPPDNYRVPLKGE--HPDYINAAFINGYKEKKAFIIAESPMFN-TARNFWKMIDDRNVTAIVMLCHENENN-QEVCYQYWPSTPSGMI
 .| | ||  ..   |  || |  .  . |. ||....|| .| |.|.|..|. . |   ||.|. .|. . |...   .|.. ..  |.         .
lnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksf

LGEYNIKLLSEETHNGYIERKFEVKQ
| |.  | | |   .  | |||  ..
lhefgaksleecelkakicrkfwpek
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 435-518 4.5e-09 30.3 In-house 26-118 (347) alignment 
Range on Protein: 435-518
Range on HMM: 26-118/347.0
PDEVTHNIASQNKDKNRSKQFLPPDNYRVPLK---------GEHPDYINAAFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
| ..| .   .. .|||||.    |. || |           .   ||||. |.  . .| .|... |. .| |.||||.   .|| .| .  
pskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 426-534 7e-09 29.5 In-house 65-156 (349) alignment 
Range on Protein: 426-534
Range on HMM: 65-156/349.0
TVLQQVTQRPDEVTHNIASQNkdknrskqflppdnyrvplKGEHPDYINAAFIN--GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENN
 .|..  . .  . .  .  .                    |   ||||| ...   .. .| .|    |.  |  .|.|.|   .|  .. | ...|..
vklkkslksskvikastsesd...................sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels

QEVCYQYWPST
 | |..||   
lekcdiywqel
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 159-244 1.3e-08 28.7 In-house 34-116 (332) alignment 
Range on Protein: 159-244
Range on HMM: 34-116/332.0
NKLLNRFANIVVYDDNRITLRPMSGHKDctneYINACYINDYSNQYQYIATQGPVSN-TLVDFWRLIWQEKSPIIIMITNVIEEGKV
|  .||   . ..| .|. | |  |. |    . || ... ||..  || .| |. . |   |||.. . |  .|... .. |. | 
nmdmnriphlycfdhsrvelapqdgkdd....fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
0038934 (Phosphotyrosine protein) phosphatases II 296-384 1.6e-08 30.0 In-house 81-165 (194) alignment 
Range on Protein: 296-384
Range on HMM: 81-165/194.0
QYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMglqqaEKEGGIDIISIINRMRQQRMKMVQTADQ
.|.   .||.|..     .|.| . ..  ..  ..|  .||| ||.|||||. |  .      .  |..    |...|. | ..... |.
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdy
subfamily_CG42327_pd Subfamily CG42327 605-676 4.7e-08 27.1 In-house 242-314 (319) alignment 
Range on Protein: 605-676
Range on HMM: 242-314/319.0
QRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQVIFQIVLTY
 ..  .  .|||||| | |. .  |.  .|.. ..    .|. |.. | | ..  .|.|..||. |....  |
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 117-199 1.1e-07 25.6 In-house 8-85 (440) alignment 
Range on Protein: 117-199
Range on HMM: 8-85/440.0
VDKFGEFVAKghAKGNKGFRNQFGMLDSGESEHTVTVGLTsSNKLLNRFANIVVYDDNRITLRPMSGHKDctNEYINACYIND
|  | ..| .   .  . | ... .| || |. .   .|  .||. ||. ||..|| .|. |  . |  |  ..|||| ||| 
vadfadyvqn..nrrsrafedewsllpsglsqpsdiaslp.nnkvknryrnilaydhsrvmleevkgvpd..sdyinasying
subfamily_PTPDC1_pd Subfamily PTPDC1 297-390 1.5e-07 26.0 In-house 85-170 (182) alignment 
Range on Protein: 297-390
Range on HMM: 85-170/182.0
YHFTSWPDHGVPEYaTSILQFHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAekeggIDIISIINRMRQQRMKMVQTADQYIFVND
..  .|.|.||.   ..||.  . ..   .  .| . ||| || ||||  .|  .  ..      ..    |. .|..| | .|| .|  .|..
vynfgwkDygvasl.eriLdivkvvafalq..egkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 560-677 6e-07 22.4 In-house 191-309 (346) alignment 
Range on Protein: 560-677
Range on HMM: 191-309/346.0
KFEVKQTNTGATQSVTqYQITNWDSTGKLTNPQTILLVIEEM--YRTQRKRGNTSIVVHCSDTVSRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKP
.. ..    | ..||   |.       .| .|   | .|  .  . ....  |. . |       |.  |  |  .||.       ......|. . |.|
eytievlpegnsdsvi.cqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrp

GSVQTVQQYQVIFQIVLTYL
|.|..  ||  |. ||. |.
ggvesfaqyasiyaivfdyi
PTEN_1 296-346 1.3e-06 23.4 In-house 96-147 (196) alignment 
Range on Protein: 296-346
Range on HMM: 96-147/196.0
QYHFTSWPDHGVPEYAtSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTF
.|.  ...|||.|  . ... . ..... ..  | ..  |||| ||.||.|| 
eylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtv
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 441-491 2.5e-06 21.6 In-house 43-94 (95) alignment 
Range on Protein: 441-491
Range on HMM: 43-94/95.0
NIASQNKDKNRSKQFLPPDNYRVPLKGE-HPDYINAAFINGYKEKKAFIIAE
  .  |  |||  . .| |  || |      |||||.|..||  |...| |.
gsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq
PTPlike_phytase Inositol hexakisphosphate 295-349 5.6e-06 21.0 Pfam-A 93-144 (149) alignment 
Range on Protein: 295-349
Range on HMM: 93-144/149.0
TQYHFTSWPDHGVPEYAtSILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAI
 .|.    .|.  || .  . .| | ||.   |..  ....|.|| ||| |.|.|
vkYvRipitdeqapeee.dvDafvrliksl..prdtalvfnCqaGrgRTTtamvi
PTPlike_phytase Inositol hexakisphosphate 295-349 5.6e-06 21.0 In-house 93-144 (149) alignment 
Range on Protein: 295-349
Range on HMM: 93-144/149.0
TQYHFTSWPDHGVPEYAtSILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAI
 .|.    .|.  || .  . .| | ||.   |..  ....|.|| ||| |.|.|
vkYvRipitdeqapeee.dvDafvrliksl..prdtalvfnCqaGrgRTTtamvi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 245-388 7e-06 19.7 In-house 149-294 (332) alignment 
Range on Protein: 245-388
Range on HMM: 149-294/332.0
KCQQYWPDSDT-KNYGPFSVTLNDEQVLTDYTVRKMHVKLVDSNDQPPLMitqyHFTSWPDH-GVPEYAT----S-ILQFHRRIKNEyKPTKGPMLVHCS
 |...||.  . |..  .|.  .|..  |     .. |     . |  ||    ||  | |   .|||      |  ||. |  |.      ||... |.
icrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlm....hfyewadasklpeymldmrasiklqyirsskkt.gvcigpimlvca

AGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMKMVQTADQYIFV
.|| .   . .||. . .  .|  . .   .. .. ||.  ..|   |   
tgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpysta
Ig_2 Immunoglobulin domain 5-92 9.1e-06 17.6 Pfam-A 1-80 (80) alignment 
Range on Protein: 5-92
Range on HMM: 1-80/80.0
KPVIEEFPSNmtTEEGREILLKVKVKETPKLSFNWYHNGEPVTDDYAHelrgdgsLLLVSVEEKHKGTYCFVANN-DAGTVSQQVVLTV
|||... |..   .||  . |  ...  |. .. ||..||...   .        |.. .|.....|||  .| |   ...|. | .||
kpvlsapptv..vtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsvevtv