Gene PTPRD-17 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP070_AA protein Get Run
AqueP070_AA_644-922 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 700-930 9.7e-131 430.0 In-house 57-287 (287) alignment 
Range on Protein: 700-930
Range on HMM: 57-287/287.0
PGADNYRVPLKGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSgIILGEYNIKLLSEETYNG
   |||||.||||||||||||||.|.||||||||||||||||||||||.|||||||||||||.|.||..||||||||.. | ..||||||.||.||...|
lvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnag

YIERKLEVNNNT-GATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRI
||||||||.|..  .. |.|.||||||||||||||.||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||
yierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqri

QKPGSVQTVQQYQGIFQIVLTYLDSFEAYSNF
|||||||||.||..|..|||.||||||.||.|
qkpgsvqtveqykfindivleyldsfetysdf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 655-928 3.9e-125 411.5 In-house 16-290 (290) alignment 
Range on Protein: 655-928
Range on HMM: 16-290/290.0
TKLNSTAVKAEWSFVSGASHYTVYYESTSSSSRKKRQVETGMRvfpgaDNYRVPLK--GEHPD----YINAVFINGFKEKKAFIIAESPMFNTARNFWKM
.| |..  .  ... ||.|..||... |||.....|. .. ..     |..|..|.  ..|.|    ||||..|.|.||||..|....|..||...|||.
akgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvy.....ddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

IDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIiLGEYNIKLLSEETYNGYIERKLEVNNNTG-ATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYR
|....||.||||....|.....|.||||....   .||..||||.|||.|.||||||||.|..  ...|||||||||||||||||||||||||||||||.
iwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

TQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFEAYS
||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 658-925 1.1e-69 229.9 In-house 20-287 (305) alignment 
Range on Protein: 658-925
Range on HMM: 20-287/305.0
NSTAVKAEWSFVSGAsHYTVYYESTSSSSRKKRQVETgmrVFPGADNYRVPLKGEHP--DYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVT
......|..  .    . ..  .... . .|.|..|.   .    | ...  | ...  ||||| ...|.|.||..|.| .|. || ..||..| .  |.
sdkgleaqykslyee.eesidvgkkeankaknrlkei...tlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvs

AIVMLCHENENNQEVCYQYWPSTPSG-IILGEYNIKLLSEETYNGYIERKLEVNN-NTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRG
 ||||..  |.... |.|||| . .    .||....| ||.|...||||||.. . ..    ..|.|||.|.|   | .. . ..| .|... ..|.|  
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFE
.....||||..|||. .|.|    ....|.|.|.|||.|||  | .... ||| .||. .....  .. ...
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
0050432 (Phosphotyrosine protein) phosphatases II 699-927 1.1e-64 214.1 In-house 77-305 (308) alignment 
Range on Protein: 699-927
Range on HMM: 77-305/308.0
FPGADNYRVPLkGEHPDYINAVFINGF--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPST--PSGIILGEYNIKLLSE
..  |. || | .|. ||||| ...|.  | ...||.. .|. ||  .||.|. . ||. ||||. . ||..| |.||||..   . .. | . ..||||
ilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllse

ETYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLK
|....|. |.||. |. .     ||... |||   |  ..|. .|  .|.. ...   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|
evlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavk

SQRIQKPGSVQTVQQYQGIFQIVLTYLDSFEAY
  | |.||.|||..||. .....| || ... .
klReqRpgmvqtpeqylflyralleylklkltk
0036941 (Phosphotyrosine protein) phosphatases II 699-923 2.8e-63 209.3 In-house 48-279 (297) alignment 
Range on Protein: 699-923
Range on HMM: 48-279/297.0
FPGADNYRVPLKGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPST-PSGIILGEYNIKLLSEET-
..  |. || |..|. ||||| ...|.. |..||... |. ||  .||.|. . ||| ||||. . |.. | |.||||.. .. .  |.. ..|||.|. 
ilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv

-YNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQ
 ...|. |.||| .. .     ||....|.|.  |  ..|...|  ||.. . ...  ... ..||||. ||||..|.|| . ..  .   .|| .|...
llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdile

VLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
..|. | |.||.|||..||. . ...| .| .
avkklReqRpgavqtleqyrflyeallellkk
0046845 (Phosphotyrosine protein) phosphatases II 702-927 8e-63 207.8 In-house 40-280 (284) alignment 
Range on Protein: 702-927
Range on HMM: 40-280/284.0
ADNYRVPLKG-----EHPDYINAVFINGF-----KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKL
 |. || ||      |. ||||| ...|.     . ||.||..  |. ||  .||.|. . ||. ||||. . ||..| |.||||.. . ...|.. ..|
ydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtl

LSEETYNGYIERKLEVNNNT-GATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---V
||||....|. |.||. |.  .     ||....|.|   |  ..|. .|  .... . ...  |.  ||||||. |||...|.|. . ..  ..||   .
lseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllg

IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFEAY
.||....|  | |.||.|||..||. .....| || ..  .
vdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_PTPRD_pd Subfamily PTPRD 712-926 1.3e-62 207.3 In-house 74-286 (564) alignment 
Range on Protein: 712-926
Range on HMM: 74-286/564.0
EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTpSGIILGEYNIKLLSEETYNGYIERKLEVNNNT
|  ||||| ||.|....||.| .  |. .| ..||.|. ..|.. |||| . .|.... | .|||.. .    ||. ..| .||... |. |........
egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.gtetygeltVtleeeeeladyeirtfklkkkk

GATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
   .. |.|.. |.| ..|  ......| .|... ... ....  ||||||  |||. .|..    ... |.|...|..|..|  | |..  ||| .||.
ssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYi

GIFQIVLTYLDSFEA
 |....| .|.... 
Fiheailealacgnt
0051299 (Phosphotyrosine protein) phosphatases II 702-921 1.9e-62 206.7 In-house 61-286 (288) alignment 
Range on Protein: 702-921
Range on HMM: 61-286/288.0
ADNYRVPLKG----EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPStPSGIILGEYNIKLLSEETY
 |. || |.     |. ||||| .|.|.. |..||... |. ||  .||.|. . ||. ||||. . |...| |.||||.  . ...|.. ..|||||..
ydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevl

NGYIERKLEVNNN----TGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVL
..|. |.||| |.     . . . ||... |||   |  ..|. .|  ...... ..  |.  .|||||. |||...|.|. . ..  ..||..||....
ddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

KSQRIQKPGSVQTVQQYQGIFQIVLTYL
|  | |.||.|||..||. .....| ||
krlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 656-921 2.2e-62 206.4 In-house 8-272 (273) alignment 
Range on Protein: 656-921
Range on HMM: 8-272/273.0
KLNSTAVKAEWSFVSGASHYTVYYESTSSSSRKKRQVETgmrvFPGADNYRVPLKGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVT
.|..| ...|.  .    ..  |. .     ..| .       ..  |. || |.... ||||| ...|.. |..||... |. ||  .||.|. . ||.
llgltllleefelllslkplltysvallpenkdknrykd....ilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

AIVMLCHENENNQEVCYQYWPSTPS--GIILGEYNIKLLSEETYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKR-
 ||||. . |...| |.||||..     .. |.. ..||||||...|. |.||. |.       ||... |.|   |  .... .|  ||.. .....  
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||..||. . ...| ||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 713-929 1.1e-61 203.2 In-house 69-301 (301) alignment 
Range on Protein: 713-929
Range on HMM: 69-301/301.0
HPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPS-GIILGEYNIKLLSEET---------------
. .|||| .|.|..|||.||.|..|| .| ..||..| .  ...|||.. ..|. .. |.||||..       |. ...| .| .               
qreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqd

--YNGYIERKLEVNNNTgaTAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLK
   |||||||..|...   ....|.|.|.|.|   | | .|.|.| ||...  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |
gsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtk

SQRIQKPGSVQTVQQYQGIFQIVLTYLDSFEAYSN
. | .||| |.| .||  |.... .||   ..|.|
avrrskpgaVtTLeqytsiydvidmylqlnstyan
0040438 (Phosphotyrosine protein) phosphatases II 653-921 4.7e-61 202.2 In-house 11-276 (317) alignment 
Range on Protein: 653-921
Range on HMM: 11-276/317.0
FITKLNSTAVKAEWSFVSGASHYtVYYESTSSSSRKKRQVETgmrvFPGADNYRVPLKGEH----PDYINAVFINGFKEKKAFIIAESPMFNTARNFWKM
.. |.. ||.. |.  .   ...  | ..    ...|..       ..  |. || |. .      ||||| ...|...|..||.. .|. ||  .||.|
dllksdftalleefedllslkld.tysvaelpenkdknrypd....ilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrm

IDDRNVTAIVMLCHENENNQEVCYQYWPStPSGIILGEYNIKLLSEETYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRT
. . .|| ||||... |...| |.||||.  . .  |.. ..|||||...|.. |.||| .. . .   ||... |.|.  |   .|...|  .|.. . 
vweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

QRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.. .... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| .||. . ...| ||
le.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 703-927 1.8e-60 199.7 In-house 69-296 (298) alignment 
Range on Protein: 703-927
Range on HMM: 69-296/298.0
DNYRVPLKG----EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGiILGEYNIKLLSEETYN
|  || |.     |. |||||.|....|...|||... |. .|  .||.|. ......||||   .| ..  . .|||.. .    || ...|||.|.. 
dssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefa

GYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRI
 .| |||.|.... .. ..| | . |.| . |  .| ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |.
dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRk

QKPGSVQTVQQYQGIFQIVLTYLDSFEAY
..||.||| .||  |...|| .||||. .
krpgavqteeqYvfiyeavlealdsfnde
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 683-918 2e-59 195.8 In-house 27-263 (283) alignment 
Range on Protein: 683-918
Range on HMM: 27-263/283.0
SSSSRKKRQVETGMRVFPgADNYRVPLKGEHPDYINAVFIN---GFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTP
 .|........    . | ||..|| || | .||||||||      |..| .||| ||. .| ..||||. |...|||||| .  |.... | ||||.  
iasadenkrknrnqeivp.adqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

SgIILGEYNIKLLSEETYNGYIERKLEVNNNTGATA-QSVTQYQITNWDSTGKVTNPQTiLLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTI
| .  ||. . |  | | | .| ..| ...|. | .   .. ||. .| . |. .   . |. .. .   |..  .. |||||| ..||.|.|.||....
s.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiins.lvkfnkvislqteskkgPivvhCstgiGrtavfiaasasv

NKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
.. .|| |.|||.|.|  | |... ||| .||. . ..||
kdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
0045450 (Phosphotyrosine protein) phosphatases II 699-921 8e-59 195.2 In-house 64-304 (307) alignment 
Range on Protein: 699-921
Range on HMM: 64-304/307.0
FPGADNYRVPLKG-----EHPDYINAVFI--------NGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILG
..  |. || |.      |. ||||| ..        .|.. |..||.. .|. .|  .||.|. . .||.||||... |...| |.||||.. . .  |
ilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltyg

EYNIKLLSEETYNGYIERKLEVNNN-TGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKT
.. ..|||||...||. |.||| ..        ||... |.|  .|  ......|  |||. . ...  ... ..||||. |||...|.|| . .   ..
nftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlek

EGV---IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
||.   .|.....|  | |.||.||. .||. . ...| .|
egtlldvdlleavkllreqRpgavqnpeqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 702-918 3.3e-58 192.3 Pfam-A 13-234 (235) alignment 
Range on Protein: 702-918
Range on HMM: 13-234/235.0
ADNYRVPL--KGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWP-STPSGIILGEYNIKLL-SEE-T
.|. || |  .... ||||| ...|.||||.||... |. .|   ||.|. ...|..||||....|...| | |||| ..      |.....|  .|.  
ydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekeked

YNGYIERKLEVNNNTGAT-AQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKS
 ..|. ||||...... .  ..|.|...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......|. .||.|..|.
ekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivke

QRIQKPGSVQTVQQYQGIFQIVL
 | |.||.||...||. . ...|
lRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 702-918 3.3e-58 192.3 In-house 13-234 (235) alignment 
Range on Protein: 702-918
Range on HMM: 13-234/235.0
ADNYRVPL--KGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWP-STPSGIILGEYNIKLL-SEE-T
.|. || |  .... ||||| ...|.||||.||... |. .|   ||.|. ...|..||||....|...| | |||| ..      |.....|  .|.  
ydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekeked

YNGYIERKLEVNNNTGAT-AQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKS
 ..|. ||||...... .  ..|.|...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......|. .||.|..|.
ekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivke

QRIQKPGSVQTVQQYQGIFQIVL
 | |.||.||...||. . ...|
lRkqRpgmvqsleqYiflykail
0039614 (Phosphotyrosine protein) phosphatases II 640-923 6.6e-58 191.9 In-house 12-291 (297) alignment 
Range on Protein: 640-923
Range on HMM: 12-291/297.0
EYTTIEIPVIETFFITKLNSTAVKAEWSFVSGASHYtvYYESTSSSSRKKRQVETgmrvFPGADNYRVPLKG-----EHPDYINAVFINGFKE-KKAFII
.......  .  ........| ...|.  .    .   |... .  ...|..       ..  |. || ||.     .. ||||| ...|..  ...||.
ipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykd....ilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIa

AESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQeVCYQYWPSTPSgiILGEYNIKLLSEETYNGYIERKLEVNNnTGATaQSVTQYQITNWDSTGKVT
.  |. .|  .||.|. . .||.||||. ..|...  |.||||.. .    |.. ..||..|...||. |.||| | .| .   ||..| |.|   |   
tqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn.nges.rtvthfqytgwpdhgvpp

NPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
.....| ..|.. . ...  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| .||. .....| .|  
slellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 711-929 9.4e-58 190.3 In-house 30-250 (250) alignment 
Range on Protein: 711-929
Range on HMM: 30-250/250.0
G----EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEvCYQYWPSTPSgIILGEYNIKLLSEETYNGYIERKLE
     .. |||||.|..|..|.||||.. .|. .|  .||.|. ......||||   .|.... . ||||   .  . |.  ..|||.|..  |. ||| 
kekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka.ekyGdvtvsllskeefadytkrklk

VNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
. ... |  . | |.. ..|   |   . ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |.| |.|||.|.|  |...|..|..
lskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphaves

VQQYQGIFQIVLTYLDSFEAYSN
 .||  ...|.| .|||.| |..
leqyvfvyeiilkaldsvedyar
DSPc_SM00195 699-921 1.8e-57 190.0 In-house 35-262 (263) alignment 
Range on Protein: 699-921
Range on HMM: 35-262/263.0
FPGADNYRVPLKGEH----PDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTP-SGIILGEYNIKLLS
..  |. || || |.     ||||| .|.| ..||..|..  |. .| . ||.|. ...|. ||||. |.||..| |..|||..  .    |....|| .
ilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklve

EETYN-GYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQV
.|...  .| |.||.....  ....|||||..||   |   ... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|..
vekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifei

LKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.|. | |.||.||| .||. | ...| |.
vkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 699-921 1.8e-57 190.0 In-house 35-262 (263) alignment 
Range on Protein: 699-921
Range on HMM: 35-262/263.0
FPGADNYRVPLKGEH----PDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTP-SGIILGEYNIKLLS
..  |. || || |.     ||||| .|.| ..||..|..  |. .| . ||.|. ...|. ||||. |.||..| |..|||..  .    |....|| .
ilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklve

EETYN-GYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQV
.|...  .| |.||.....  ....|||||..||   |   ... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|..
vekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifei

LKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.|. | |.||.||| .||. | ...| |.
vkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 712-929 3.7e-57 188.8 In-house 72-288 (318) alignment 
Range on Protein: 712-929
Range on HMM: 72-288/318.0
EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSgIILGEYNIKLLSEETYNGYIERKLEVNNNT
|  ||||| .|.|...|||.| | .|. .| ..||.|. ..| . |||| .|.|. .. . .||||  | . .|.  ..| .| ... |. |...|... 
egsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrte

GATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
    . | ||..|.|  .|  ... ..| .. .  ..|.| |.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  ||| .||.
eeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqye

GIFQIVLTYLDSFEAYSN
 |....| .| |.... .
fiydvllealasgdtevd
0043336 (Phosphotyrosine protein) phosphatases II 699-921 1.3e-56 187.5 In-house 54-277 (278) alignment 
Range on Protein: 699-921
Range on HMM: 54-277/278.0
FPGADNYRVPLKGEH----PDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPstPSGIILGEYNIKLLSE
..  |. || |. .      ||||| ...|.. ...||..  |. .|  .||.|. . .|| ||||. . |.... |.||||   . .  |.. ..||.|
ilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllke

ETYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLK
|....|. |.||| |.     . ||.|. ..|   |  ......|  .... . ..   |. ..||||. |||...|.|. . ..  ..|| .|.....|
ehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavk

SQRIQKPGSVQTVQQYQGIFQIVLTYL
  | |.||.||| .||. .....| ||
elreqRpgavqtpsqyrflyealleyl
0042113 (Phosphotyrosine protein) phosphatases II 702-921 4.9e-54 178.7 In-house 21-243 (245) alignment 
Range on Protein: 702-921
Range on HMM: 21-243/245.0
ADNYRVPLKGEH----PDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPStPSGIILGEYNIKLLSEETY
 |. || |. .      ||||| ...|.. .. ||..  |. .|  .||.|. . ..|.||||. | |.... |.||||.  . .  |.. ..|||||..
ydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehl

NGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQR
..|. |.||| |.     . |..|. ..|.  |  ......| ..|.. . ... .|. ..||||. |||...|.|| . ..  ..|. .......|  |
ddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelr

IQKPGSVQTVQQYQGIFQIVLTYL
 |.||.||| .||. . ...| .|
sqRpgavqtpsqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 702-921 1.6e-53 177.2 In-house 23-246 (249) alignment 
Range on Protein: 702-921
Range on HMM: 23-246/249.0
ADNYRVPLKG----EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPStPSGIILGEYNIKLLSEETY
 |. || |.     .. ||||| .|.|.. |..||..  |. .|  .||.|. . ..|.||||... |...| |.||||.  . .  |.. ..|||.|..
ydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevk

NGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQ
..|. |.||. |.   .   |...|.|.|  .|   .....|  ||..   ...   .. ..||||. |||...|.|| . ..  ..|. .|.....|  
ddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkll

RIQKPGSVQTVQQYQGIFQIVLTYL
| |.||.||. .||. . ...| .|
rsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 702-921 1.7e-53 177.2 In-house 45-272 (278) alignment 
Range on Protein: 702-921
Range on HMM: 45-272/278.0
ADNYRVPlkgehpDYINAVFINGFkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPStPSGIILGEYNIKLLSEETYNGYI
 |. ||       ||||| .|.|.  .|.||..  |. .|. .||.|. . ..|.||||... |...| |.||||.  . .. |.. ..|||||... |.
ydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddyt

ERKLEVNNN----TGATAQSVTQYQITNWDSTGKVTNP--QTILLVIEEMYRTQR------------KRGNTSIVVHCSDTVGRSAMFCAAATTINKCkt
 |.|.| |     .. .   ||......|.  |  ..|  . .| ..|.. . ..              ... ..||||  |||.....|| . .  .  
lrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..

EGVIDVFQVLKSQRIQKPG-SVQTVQQYQGIFQIVLTYL
||..|.....|  | |.|| .||. .||. ... .| .|
eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 660-925 2e-53 176.5 In-house 23-287 (319) alignment 
Range on Protein: 660-925
Range on HMM: 23-287/319.0
TAVKAEWSFVSGASHYTVYYESTSSSSRKKRQVEtgmrVFPgADNYRVPLK----GEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVT
| .. |.  ...|.  |..  |.   ..| |  .    . .  |. || |.     |  ||||| ||.|..|...|| . .|. ||  .||.|. .... 
tllekefkllkeavndtfdsaskeenkkknryqn....ila.ydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

AIVMLCHENENNQEVCYQYWPSTPSgIILGEYNIKLLSEETYNGYIERKLEVNNNTGAT-AQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGN
 .|||.. .|. .  . .|||..      |.. ..|..||  ..|| |||..|....   . .|...| |.|   .  .. ...| ..... ....|  .
ivvmltklveklkvklkkywpeenf.eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqs

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFE
  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||. .||. |....| ......
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_PTPRA_pd Subfamily PTPRA 712-920 1.3e-50 167.2 In-house 84-294 (330) alignment 
Range on Protein: 712-920
Range on HMM: 84-294/330.0
EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSgIILGEYNIKLLSEETYNGYIERKLEVNNNT
|. ||||| ||.|.|||. || |  |  .|  .||.|| ... ..|||| . .| ..| |.||||.  . .  |. ....  |.  . |  ||. |.. .
eesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlp

GAT----AQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 ||    .. |.|.  | |   |  ..|. .| ..... ..... .. .||||||  |||.  |..  . ... |.|...|||...|. | |.|  ||| 
datrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtd

QQYQGIFQIVLTY
.||. |....| |
eqyefiykvlley
subfamily_Ptp69D_pd Subfamily Ptp69D 697-922 3.5e-50 165.8 In-house 55-287 (307) alignment 
Range on Protein: 697-922
Range on HMM: 55-287/307.0
RVFPGADNYRVPLK----GEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTpSGIILGEYNIKLL
      |..|| ||     |. ||||| ||.|.|||| ||.|  |. .|. .||.|| . .|| ||||  ..| |.. | .|||     .  |. ..|| 
edikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklv

SEETYNGYIERKLEVNNNTG-----ATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVI
|||. . ||.|.|.| ..          . |.||. |.|. .     ....| .||...  ...  .. ||||||  ||||..| | .  ....|.|  .
seekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkv

DVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
|.|.. |  | |..  ||  .||. ... .| | .
difetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 711-923 1.4e-48 160.5 In-house 66-278 (281) alignment 
Range on Protein: 711-923
Range on HMM: 66-278/281.0
GEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKLLSEETYNGYIERKLEVnNN
 .. ||||| |..|.|..|..|....|. ..  .||.|. ...|.||||. .| |...  |..|||   | ...|.. .| ..||. . |||||... ..
nkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.er

TGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQ
... ...|.| . |.|  .|  .... .|   .|......|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||| |
esgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvq

YQGIFQIVLTYLDS
|. ....|| .|| 
yefvykavldaldk
0037934 (Phosphotyrosine protein) phosphatases II 702-920 9e-47 155.0 In-house 22-241 (243) alignment 
Range on Protein: 702-920
Range on HMM: 22-241/243.0
ADNYRVPLKGehPDYINAVFINGFKeKkaFIIAESPMFNTARN----FWKMIDDRNVTAIVMLCHENENNQEVCYQYWPstpS-GiILGEYNIKLLSEET
 |. || |.|   ||||| .|.... .  .|.   |. .|  .    ||.|. . ..|.||||... |...| |.||||   .     |.. ..|||||.
ydhsrvkleg..sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.tygdftvtllseeh

YNGYIERKLEVNNNT-GATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGvID
...|. |.|.. |   .   . |..|. ..|   |  ..|. .|  ..|..  ...        ..  ..||||  |||.....|| . . ..   | .|
lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vd

VFQVLKSQRIQKPG-SVQTVQQYQGIFQIVLTY
.....|  | |.|| .||| .||. . ...| .
leeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRB_pd Subfamily PTPRB 703-923 1.4e-46 153.9 In-house 64-287 (293) alignment 
Range on Protein: 703-923
Range on HMM: 64-287/293.0
DNYRVPL----KGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKLLSEETYN
|. || |    . .. ||||| .|.|.. .. || .  |. .|  .||.|. ......|||| .  |. .. | .|||.. . .. |. ...|..||...
dhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeele

GYIERKLEVNNntGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQ-RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQR
 .. |.|....  . . ..|.||. | |   |   ...|.|  .... ... ..  .. ||||||  |||.  | |  . ... ..| ..|.| .. . |
dwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelR

IQKPGSVQTVQQYQGIFQIVLTYLDS
 ..   |||..||  | | ||..| .
eeRnllvqtekqYifihqcvldllrk
subfamily_PTPRG_pd Subfamily PTPRG 703-924 2.9e-46 152.8 In-house 60-290 (563) alignment 
Range on Protein: 703-924
Range on HMM: 60-290/563.0
DNYRVPLK---G--EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPStPSGIILGEYNIKLLSEETY
|. || |.   |  .. ||||| .|.|.. .||||..  |. .|.  ||.|| ..||. |||.   .|.... | .|||.    . .|. ...| .||. 
drsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevl

NGYIERKLEVNNN----T--GATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQ
  | .|.| ..|     .    | . |.||. |.|  .|  . .   |  ..   .....     ||||||  |||. ....  | ... ..| ...||.
alytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfg

VLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
.||  | |..  |||  ||. .....|  . | 
flkhiraqRnflvqteEqYiflhdalleaiask
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 707-921 3.6e-46 152.3 In-house 60-276 (515) alignment 
Range on Protein: 707-921
Range on HMM: 60-276/515.0
VPL----KGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPS-GIILGEYNIKLLSEETYNGYI
| |       | ||.|| .|..|.  ||.| .  |   .  .||... . |||.|.|. . .|...  | .|||  |.  . .|.....|.| |.  | |
vklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggi

ERKLEVNNNTGatAQSVTQYQITNWDSTGKVTNPQTILLVIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKP
 |||.|  .    .. |||.. |.|   |   . ...| .| |. .... . . ....|||  |||  .....   . . ||  ..|||....  | ..|
krkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrp

GSVQTVQQYQGIFQIVLTYL
  ||| .||  |...|| .|
ylvqtqeqyafiygavledl
subfamily_PTPN12_pd Subfamily PTPN12 712-921 4.3e-46 152.1 In-house 66-277 (290) alignment 
Range on Protein: 712-921
Range on HMM: 66-277/290.0
EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGII-LGEYNIKLLSEETYN-GYIERKLEVNN
|. ||||| ||.| ..|...| | .|. .|  .||.||.. ||. .||.|.| |...  | .|||..    .  ||....| .|.. . ... | |.|..
egsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkvea

NtgATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQT
.   . ..|.|.. |.|   |  ......| .||.. |. ... .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  |||
q..kesrkvyqfhYtaWPDhgvPssaksllelielv.relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqt

VQQYQGIFQIVLTYL
 .||. ... |. ..
keqyelvykavaelv
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 704-922 7.2e-46 151.5 In-house 61-282 (288) alignment 
Range on Protein: 704-922
Range on HMM: 61-282/288.0
NYRVPLKG----EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKLLSEETYNG
  || ||.    .  ||||| .|.| |.||..| . .|. .|  .||... ..... |||| .  |.... | .|||..      |. ...|..... . 
ekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeled

YIERKLEVNnnTGATAQSVTQYQITNWDSTGkVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQ
...|||...     |   .|||| . |  .| | . .. || . ..  .. .     |.||||. |||.  | |. . |.. ..| .|||. ...  | |
fvlrkllle..kkkteleitqyqylaWpdhg.vPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkq

KPGSVQTVQQYQGIFQIVLTYL--D
..  |||..||. |....|.    |
RallvqtlkqYefiyevllslieed
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 706-922 7.3e-46 151.5 In-house 60-278 (315) alignment 
Range on Protein: 706-922
Range on HMM: 60-278/315.0
RVPL----KGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPS-TPSGIILGEYNIKLLSEETYNGY
|| |    .  . ||||| .|..... ||.| .  |   .  .||.|. . .||.|||. . .|...  | ||||      . .|.....||| |.  . 
rvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdg

IERKLeVNNNtGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQK
. ||| |  . . . . |||.| |.|   |   .  ..| .| |.    ... . |..||||  |||. .....   ... | . ..|||...|  | ..
varkl.vtrk.seesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakr

PGSVQTVQQYQGIFQIVLTYLD
|  ||| ..|  |...|| .| 
pylvqteeeyafiydavledll
subfamily_PTPRK_pd Subfamily PTPRK 675-919 9.5e-46 151.0 In-house 28-275 (314) alignment 
Range on Protein: 675-919
Range on HMM: 28-275/314.0
YTVYYESTSSSSRKKRQVETGMRVFPGADNYRV---PLKGE-HPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEV
|  ..|   .. ..... .  .      |. ||   ...|. . ||||| .|...|  .|||..  |. .| ..||... | | ..|||| .  |. .  
yeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvk

CYQYWPSTPSGiiLGEYNIKLLSEETYNGYIERKLEVNN--NTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKrGNTSIVVHCSDTVGRS
|..|||   .    |. ...|.. |. . .. | . |..   .    . | |.| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||.
ClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrt

AMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
 .|.| .. ..  ..|||.|||.. |. | .|.  |.| .||. |....| 
Gtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 713-924 2.1e-45 150.1 In-house 78-287 (297) alignment 
Range on Protein: 713-924
Range on HMM: 78-287/297.0
HPDYINAVFINGFKEkkAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQeVCYQYWPSTPSGIiLGEYNIKLLSEETYNGYIERKLEVNNNTG
  ||.|| |..|.|.   .|  . || .|  .||.|. | .|..|||| ..||...  | .||. . .   .|.  ..||| .  .|.|.|.|||...  
dsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgka

ATAQSVTQYQITNWDSTGKVT--NPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
 . . | ||| ..| .       . ...| .|.|.  .  .. .. ..|||.  ||| .....    . . | |  .|.|...|  | ..|  ||| .||
karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqy

QGIFQIVLTYLDSF
. ....|| .| | 
kfvyvavleallse
subfamily_PTPN23_pd Subfamily PTPN23 698-921 9e-44 144.4 In-house 52-280 (288) alignment 
Range on Protein: 698-921
Range on HMM: 52-280/288.0
VFPgADNYRVPLKGEHPDYINAVFINGFKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTP-SGIILGEYNIKLLSEE
..|  |. || |.|.. ||||| |...       ||.. .|. .|.  ||.|. .. .  |||| ...| ... . .|||.        |.... | |..
ilP.yDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr

TYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVI---EEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQ
. . ..||.|... .   . .||.  |.|.| . |    |.|.| ..   |..|...... .| .|||||  |||. .|.   . ... .  .|..|. |
etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiq

VLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
|..  | |.  .||...|..  ...||.. 
vvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 712-921 1.4e-43 144.3 In-house 74-288 (325) alignment 
Range on Protein: 712-921
Range on HMM: 74-288/325.0
EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNvTAIVMLCHENENNQEVCYQYWPST-PSGIILGEYNIKLLSEETYNGYIERKLEVNNN
 . ||||| ... .|.|. |. | .|. .|  ..|... | . ...|..  | ..... | .|||        .|  ..|| . |..  |. |.|.| . 
pssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqv

TGATAQSVTQYQITNWDSTGKVTNPQTILLVI---EEMYRTQR--KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQ
 .  ..|| |.|.  ||  |    | |.. ..   ...  . .   .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.
kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmve

TVQQYQGIFQIVLTYL
|| ||  |.. .  ..
tvdqyiliyealveay
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 710-919 1.1e-42 141.0 In-house 73-277 (315) alignment 
Range on Protein: 710-919
Range on HMM: 73-277/315.0
KGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTpsGIILGEYNIKLLSEETYNGYIERKLEVnn
. .| ||.|| ||.|.. |. .| |..|  .. ..||... . ... ||||    |.... . .|||     .| |.. . . ||| .. |  | | |  
ndphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsv..

NTGATAQSVTQYQITNWDsTGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
  |   . | |...| |  . .|..  . |. .    .  ..   ..||||||. |||.  |..  . ... ..| .|||.....  | .. . ||...|
vfgdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeq

YQGIFQIVLT
|| |....| 
yqfiydalle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 712-919 5.1e-42 139.3 In-house 87-289 (319) alignment 
Range on Protein: 712-919
Range on HMM: 87-289/319.0
EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenennQEVCYQYWPSTpSGIILGEYNIKLLSEETYNGYIERKLEVNNNT
|  ||||| |..|.. |. .| |  |. ||  .||.|| . |...||.|       .. | ||||     |  .....|. | |  . |. |..|. ...
efsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplk.ivikeerfkvkvdsveetaeyvvrdielsedg

GAT-AQSVTQYQITNWDSTGKVTNPQTILLVIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
  .  ...||. .  |   |.   |  .. ...   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || . |
kekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvq

YQGIFQIVLT
|. |.  .| 
ykfiysalle
subfamily_PTPN6_pd Subfamily PTPN6 698-923 7.2e-42 138.4 In-house 63-299 (306) alignment 
Range on Protein: 698-923
Range on HMM: 63-299/306.0
VFPGaDNYRVPLK---GEHPDYINAVFINGF--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKLL
..|  |. || ||       ||||| .|..   ...|..| ..  . .|  .||.|. . | . |||. .|.| ..| |..|||.. .    |..... .
ilPf.DhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnv

SEETYNGYIERKLEVN-NNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV--
||.. . || |.| |. .... ....| ||. ..|   |  ..|...|  .|.. | |..     . .||||||. .||   |    . ... ...|.  
seksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkglda

-IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
 ||. .. || | |. | ||| |||. ..... .|...
didiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 712-919 8.5e-42 138.6 In-house 51-253 (284) alignment 
Range on Protein: 712-919
Range on HMM: 51-253/284.0
EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenennQEVCYQYWPSTpSGIILGEYNIKLLSEETYNGYIERKLEVNNNT
|  ||||| ||.|.. |. .| .  |. ||  .||.|| . |...||.|       .. | ||||     |  .....|. | |  . |. |..|. ...
efsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk.ivikeerfkvkvdsveeseeyvvrdielsedg

GAT-AQSVTQYQITNWDSTGKVTNPQTILLVIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
  .  ....|. .  |   |.   |  .. ...   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || . |
kekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvq

YQGIFQIVLT
|. |.  .| 
ykfiysalle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 711-922 1.5e-41 137.3 In-house 54-269 (274) alignment 
Range on Protein: 711-922
Range on HMM: 54-269/274.0
GEHPDYINAVFINGFKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEY---NIKLLSEETYNGYIERKLE
 |  .|||| .| |..| .||.. .  |. ||  .||.||  ..|. |||| . .|.|.. | .|.| . .  | ..|   .||  .  . |.|  ||| 
dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklv

VNNNTGatAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSV
... .    .||. |  |.|  .    ...|.| ...|. ...... .   ..|||||  .||  .| |.  .... . |.|.||...    |... | |
lkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmv

QTVQQYQGIFQIVLTYLD
|| .||. |....  || 
qtseqyelihralclylk
subfamily_PTPN3_pd Subfamily PTPN3 702-918 2e-40 133.5 In-house 53-272 (280) alignment 
Range on Protein: 702-918
Range on HMM: 53-272/280.0
ADNYRVPLKGEHPDYINAVFIN----GFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKLLSEETY
 |. || || .. ||||| ..|    . .  . .|..  |. .|| .||.|. ..... ||||    |. .  |.||||.|   . .||...|. .|.. 
ydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedet

NGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQR
. |. |.| .....    ....| | ..|   |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  |.. .  ..  . . ....  |
ksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmr

IQKPGSVQTVQQYQGIFQIVL
 |.   |||..||. . . .|
dqramlvqtasqykfvCeail
subfamily_CG7180_pd Subfamily CG7180 710-920 9.6e-40 131.0 In-house 65-289 (296) alignment 
Range on Protein: 710-920
Range on HMM: 65-289/296.0
KGE-HPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQeVCYQYWPSTPsGIILGEYNIKLLSEETYNGYIERKLEVN
.|| . ||||||....|  ||..|. | |. .|  .||... |... |.|.|... . ..  . .||| .      ||  .....|..|     |.. ..
dGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfklt

NN----------TGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRG-----NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVL
 .            |    |...|.| |..  ||    . |. . .. |. |..      .  .||..|| ..|| ...|.  .... . |. .|||. .
kkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeav

KSQRIQKPGSVQTVQQYQGIFQIVLTY
|  |...|. |..|..|. |....| .
ktlrrsRpqLvenveeYkyiYdvllea
subfamily_PTPN9_pd Subfamily PTPN9 712-921 1.3e-39 131.0 In-house 68-290 (297) alignment 
Range on Protein: 712-921
Range on HMM: 68-290/297.0
EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWP-STPSGIILGEYNIKLLSEETYNGYIERKLEVNNN
|. ||||| |..|.|.||||| .  |. .| ..||.|. ...|  |||  .  |. .  | |||| .. | .  |..... .. |... | .|.||..| 
easdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknv

TGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQR---------KRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRI
.    ..|| .|.. |   |   . ...| |.|.. ..|          ..|   .  ||||||  .||.  |..   .... ...|..||....|  | 
kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrt

QKPGSVQTVQQYQGIFQIVLTYL
|.  |.|| .||.  .. || | 
qrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 713-922 1.4e-39 130.7 In-house 47-265 (270) alignment 
Range on Protein: 713-922
Range on HMM: 47-265/270.0
HPDYINAVFINGFKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSG---IILGEYNIKLLSEETYNGYIERKLEVN
.  |||| ...||.. ||..| | .|. .| ..||.|| ...||||||. . .|.... | .|||. |     .  |. ..  ||||  .||| ..|...
ataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle

nNTGATAQSVtQYQITNWDSTGKVTN------PQTILLVIEEMYRTQRKRGN-TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKP
 ..| . . |  .. ..|   | ...      .. .| ..... |....  . . ..||||. |||. .. |  ....  .... .|| ....  | ...
.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRm

GSVQTVQQYQGIFQIVLTYLD
  ||...||. ... |..| .
alvqhpeqyeflykavveyae
subfamily_PTPN1_pd Subfamily PTPN1 682-916 9.2e-38 124.6 In-house 25-266 (290) alignment 
Range on Protein: 682-916
Range on HMM: 25-266/290.0
TSSSSRKKRQVETGMRVFPgADNYRVPLKGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPS-
...   . |. .    | |  |  |. |. .. ||||| ...  . |. .|..  |. ||.  ||.|. ...  |.||| .  |..|  |.||||.  . 
reaklpenrnlnryrdvsp.ydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeee

-GIILG--EYNIKLLSEETYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQR-KRGNTSIVVHCSDTVGRSAMFCAAAT
  ..|   ....||.|||... |. |.||..| .   .......  | |   |    |.. |  . .. ..   ..     |.|||  .|||  || . |
kellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt

TIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQI
 .    | .    .|. .||   | .. | .|| .| .  .. 
clvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyla
subfamily_PTPN13_pd Subfamily PTPN13 697-923 4.5e-37 122.8 In-house 45-271 (273) alignment 
Range on Protein: 697-923
Range on HMM: 45-271/273.0
RVFPgADNYRVPLKGEHPdYINAVFINGF--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPS-GIILGE-YNIKLL
 |.|  |. ||.|..| . |||| .|.    |..  .|..  |. .|...||.|. ..... |.|. .| |...  | .|||.. .  . . . ....||
nvlP.ydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevell

SEETYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQV
  . ..|.  |.|.|...  . .. |.. . ..|   |  .... .| .. |. | |.   .. ||||||  .||| .. .  . ..  . .  .|| ..
kvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkei

LKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
... | |. | ||| .||  .....|. | |
vrklreqrqgvvqtkdqyifvykailevlks
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 708-922 5e-36 118.9 In-house 58-278 (287) alignment 
Range on Protein: 708-922
Range on HMM: 58-278/287.0
PLKGEH-PDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKLLSEETYN-GYIERKL
  .||.  ||||| .. ......||| | .|.  | |.||... .......... .| |. .  ||.|||     . .| | . ||. .  .  |  | |
saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvral

EVNNNTGATAQSVTQYQITNWdsTGKVTNPQ---TILLVIE--EMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQ
 . .  .  |. | |... .|    ||  |     | .|..  .    .|.  .   .|||..  .||| .. |  . ... .  | .|| .|.   | .
rlidletrearvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlrey

KPGSVQTVQQYQGIFQIVLTYLD
. . ||.| |.. ... . ||  
raalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 703-920 6.5e-36 118.7 In-house 46-258 (267) alignment 
Range on Protein: 703-920
Range on HMM: 46-258/267.0
DNYRVPLKGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNqeVCyQYWPST-PSGIILGEYNIKLLSEETYNGYI
|. ||.|. .  .|||| ...|.| |.|||. . |. ||  .|...| |..|. ||.| .  ..|  .  ..||          .  ..   |.  | | 
ddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn..ir.lfwPPkmgqakkyqdltvehslekeendyq

ERKLEVNNNTgATAQSVTQYQITNWDSTGKvtNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKP
   ||.. .   .|. || |   .|.   .  |   .  ..  . . | . ||  .||.||| ||||  |  . . ... ||||| |.|. |.  | |..
iitlelkfkn.esahnvtlyyykkwnintn..nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqri

GSVQTVQQYQGIFQIVLTY
| |.| ..|  | ...  |
glvdtkeryiyihellaey
0051429 (Phosphotyrosine protein) phosphatases II 713-924 5.4e-34 113.5 In-house 3-228 (272) alignment 
Range on Protein: 713-924
Range on HMM: 3-228/272.0
HPDYINAVFINGFKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVMLCHENENNQEVCYQYWP-----------STPSGIILGEYNIKLLSEETYN
 ..|||| ...|.     ..... .  |. .||..||..  . ....||.|..|.| ... |..|||           ...  | .| . ..|||||...
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERKLEVNNN-TGATAQSVTQYQITNWDSTGKVTNPqtILLVIEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------V
 || |.|.. .  .  .|  |.... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
.....  | | ||.||| .||. .....| .|.|.
eeaveelraqrpgavqteeqylflyeallellrsl
0036282 (Phosphotyrosine protein) phosphatases II 715-915 1.4e-33 111.4 In-house 3-164 (174) alignment 
Range on Protein: 715-915
Range on HMM: 3-164/174.0
DYINAVFINGFKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPStpsgiilgeynikllseetyngyierklevnnNTGAT
||||| .....   . .|.   |.      ||.|. . ..|..|||..|.|.. . |..|||.                                .    
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lredl

AQSVTQYQITNWDSTGKVTNPQtILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
 ... ||. ..|.  |  . .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.||| .||. . 
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Q
.
y
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 703-918 4.8e-33 109.3 In-house 16-236 (237) alignment 
Range on Protein: 703-918
Range on HMM: 16-236/237.0
DNYRVPLKG--EHPDYINAVFINGFKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKLLSEETYNG
|  || |||     ||||| ...||    | .| |. |. ..  .||.|. . . . ||||    |.|.. |..|||||      | . . |  .| .  
dhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsd

YIERKLEVNNN-TGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQR
|  | | . .. |    . . |||.| |   |   .  ..|    ..    ..    .  ..|||  |||...|    . . ..| . |.|... ..|  
ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysie

IQKPGSVQTVQQYQGIFQIVL
 ..|  .|| .||  |.| .|
edrpyiiqtkdqyvfihqtil
subfamily_PTPRN_pd Subfamily PTPRN 702-917 3e-32 106.5 In-house 68-288 (297) alignment 
Range on Protein: 702-917
Range on HMM: 68-288/297.0
ADNYRVPLKG----EHPDYINAVFINGFKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIiLGEYNIKLLSEET
 |. || ||     |. ||||| .|     .  |.| ...|. .|  .||.|. .. |. ||.|.. .|.. . |..||| . | .  . |...|.||  
ydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsev.yhiyevhlvsehi

Y-NGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGnTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLK
. . |. | . . |     ...|||.    | ..|  ......|     . .. | |  ..||||||| .||. ....    .|.  |    ||.   |.
wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatle

SQRIQKPGSVQTVQQYQGIFQIV
  | |.|| |.| .|.. ... |
hlrdqrpglvktkdqfefaltav
subfamily_PTPN14_pd Subfamily PTPN14 658-922 7.8e-31 102.2 In-house 21-297 (300) alignment 
Range on Protein: 658-922
Range on HMM: 21-297/300.0
NSTAVKAEWSFVSGASHYTVYYESTSSSSRKKRQVEtgmRVFPGADNyRV---PLKGEHPDYINAVFING--FKEKKAFIIAESPMFNTARNFWKMIDDR
... | .|.  ..  .. .... ..     .| ...    | |  || ||   | | .. .||||  |.     ... .|.| .|. .| ..||.|. . 
eegkvfteyeripkkredallstaklpenaeknrfk...dvlPyedn.rvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeq

NVTAIVMLCHENENNQEVCYQYWPST---PSGIILGEYNIKLLSEETYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQ
.|. |||| .|.|. .| ...|.|..    . .  |....     |. . .| ..|...       ..|   | |.|   |   .... |  .||.   .
gvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvr

RKRGNT--------SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
||  ..         ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. ||. .......||.
rktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0041856 (Phosphotyrosine protein) phosphatases II 706-919 3.2e-29 97.2 In-house 17-169 (182) alignment 
Range on Protein: 706-919
Range on HMM: 17-169/182.0
RvplkgeHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChenennqevCYQYWPSTPsgiilgeynikllseetyngyierkl
|      ..||||| .. |    . ||..  |. .|  .|..|. ....|.||.|.         ...|||.                            
r......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell..........................

evnnntgatAQSVTQYQITNWDSTGKVTnPQTILLVIEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDVFQVLKSQRIQKPGSVQ
          . ..||. ..|.  |  . ....|  |||...      .  ..||||  |||.....||   . .    | .......|  | ..||.|.
.........erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvi

TVQQYQGIFQIVLT
| .||. . ...| 
tpnqyfflqlalle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 717-910 5.7e-29 95.8 In-house 78-270 (301) alignment 
Range on Protein: 717-910
Range on HMM: 78-270/301.0
INAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPS-GIILGEYNIKLLSEETY--NGYIERKLEVNNNTGA
| | .|.   . . ||.. .|. ||. .|| |.   .|  ||||... |...|.| .| |...|  . .| ..||. ..|.   .  ..|.|||.. || 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

-TAQSVTQYQITNWDSTGkvtNPQTILLVIEEMYRTqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
 ....|| || ..|   |    |..   . . |     |. .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||..| 
fatrtvthyqysewtdrg...vPkshaelfdlmelv..kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 701-924 1.4e-28 94.4 In-house 67-286 (290) alignment 
Range on Protein: 701-924
Range on HMM: 67-286/290.0
GADNYRVPLK-GEHPDYINAVFINGFKekKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSG-IILGEYNIKLLSEETY-
  |  || || | . ||. | ...| |    ||... .. .|. ..|.|. . .|.||||||   |. .  | ||.| .    . .||. .    |..  
cndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkd

NGYIERKLEVNNNTGATAQSVTQYQITNWDSTGkVTNPQTILLvieEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTInKCKTEG-VIDVFQVLKSQ
.  | . | | .        .  ..|  |     |.. .  ||    . |. ||  .  .|||||  .||.  | |  ... .. ..|  .|. .. .. 
aniikktlsvrdkdsGkehklkhlkikswpdks.valstlall...rtlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvral

RIQKPGSVQTVQQYQGIFQIVLTYLDSF
|  . .|||   ||  . .|.| .  .|
rnsrlnsvqvdiqylalveilldlGkdf
0046846 (Phosphotyrosine protein) phosphatases II 706-922 8.1e-28 92.8 In-house 4-174 (176) alignment 
Range on Protein: 706-922
Range on HMM: 4-174/176.0
RVPLKGEHPDYINAVFINGFKekkaFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIIlgeynikllseetyngyierkl
|..  ....||||| .| | .    .|.   |. .|  .|..|. . ..||.|.|. | | ..  |..|||   .  |                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

evnnntgataqsvtQYQITNWDSTGKVTNpQTILLVIEEMYRTQRKrGnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSV
              ||. ..|.  |  .  . .| ..|.... ... |   ..||||  .||.....||      ...|  ..|...|.  | |.| |.|
..............qylhlpwpDhgvpdl.elllellefirealke.g.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTVQQYQGIFQIVLTYLD
|| .||. . . .| .|.
qtpeQyrflyefellllk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 705-920 1.4e-27 91.1 In-house 60-235 (392) alignment 
Range on Protein: 705-920
Range on HMM: 60-235/392.0
YRVPL----KGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNqevcyqywpstpsgiilgeynikllseetyngy
 || |       . ||.|| .|..|. .||.| ...|   .  .||.|. . |||.|.|. . .| .                                 
arvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.................................

ierklevnnnTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMyrtQRKRGNTS--IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRI
           |  |..|.|...|.|   .      ..| .|.|.   . . |. .  ...|||  |||...  .  . . ..|.  ..|||...   | 
..........kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirr

QKPGSVQTVQQYQGIFQIVLTY
..|  ||| .||  |.  ||  
krpymvqtkeqyafiygavled
0049260 (Phosphotyrosine protein) phosphatases II 721-914 2.3e-27 90.9 In-house 1-143 (152) alignment 
Range on Protein: 721-914
Range on HMM: 1-143/152.0
FINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWpstpsgiilgeynikllseetyngyierklevnnntgataqsvtQ
||.|.. ...||... |. ||. .||.|. . ..|.||||. . |.. . |.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YQITNWDSTGKVTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
|. ..|.  |  ...| .| ... . .  ... .  ..||||  |||.....||   .        ........  | ..||.|.. .|.. ..
ylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0043147 (Phosphotyrosine protein) phosphatases II 712-914 4e-27 90.4 In-house 3-154 (172) alignment 
Range on Protein: 712-914
Range on HMM: 3-154/172.0
EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEnennqevcyqywpstpsgiilgeynikllseetyngyierklevNNNT
|. ||||| ....    . ||.   |. ||   ||.|. ....|.||.|. .                                             ...
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

GATAQSVTQYQITNWDSTGKVtNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVQQY
    ... ||. ..|.  |   ... .| ..| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||. .||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqy

QGIF
. . 
rfly
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 712-918 2.1e-26 87.5 In-house 33-237 (239) alignment 
Range on Protein: 712-918
Range on HMM: 33-237/239.0
EHPDYINAVFINGFKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIilGEYNIKLLSEETYNGYIERKLEVNNN
 | ||||| ..  .    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| . |     .  . |   | .  || | . ... 
phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky..cnlrvtlrktevfadyiirtfvmsqv

TGATAQSVTQYQITNWDSTGkVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
  .  . | ||..| |   | | .  | .| .      .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| .||
gqteeryvyqyhftvwpdkg.vpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy

QGIFQIVL
  |.  ||
vfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 712-918 2.2e-26 87.5 In-house 34-238 (239) alignment 
Range on Protein: 712-918
Range on HMM: 34-238/239.0
EHPDYINAVFINGFKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIilGEYNIKLLSEETYNGYIERKLEVNNN
 | ||||| ..  .    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| . |     .  . |   | .  || | . ... 
phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky..cnlrvtlrktevfadyiirtfvmsqv

TGATAQSVTQYQITNWDSTGkVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
  .  . | ||..| |   | | .  | .| .      .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| .||
gqteeryvyqyhftvwpdkg.vpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy

QGIFQIVL
  |.  ||
vfihlavl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 712-919 8.6e-25 82.1 In-house 74-277 (439) alignment 
Range on Protein: 712-919
Range on HMM: 74-277/439.0
EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENEnnqevCYQYWPSTpSGIILGEYNIKLLSEETYNGYIERKLEVNNNT
 |  |||| .|.|. ..| .| .. |  .|. .||... ..... ||||.   |      |.||||  . .. |.  ..   .     |. | . | |. 
phshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve.....sykywpsd.aevcygdiavrvdrnielpnyvirgfkvfner

G--ATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQ
      ..| |.. . |      ..   .|  .  .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||.. |
dttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcq

YQGIFQIVLT
|  |.. || 
yvfiynavle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 707-920 4.4e-24 79.6 In-house 54-268 (281) alignment 
Range on Protein: 707-920
Range on HMM: 54-268/281.0
VPLKG-----EHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGII-LGEYNIKLLSEETYNGY
| ||      .  ||| | .|     |. .|... |  .|  .||.|| . | |||||||.  | |.| | .|.|      . . .. ..       .  
vqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnksl

IERKLEVNNNtgATAQSVTQYQITNWDSTgKVTNPQTILLVIeemYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG-VIDVFQVLKSQRIQ
.  .|..  .    .. .|..   .|    .| .   ..| |    |  | |  |  |.|||  ||||  . |   ...  ..   . |. |..   |. 
vttrlnlsye..getrlithwlwkewpdw.qvpessevmlki...lrkirar.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvt

-KPGSVQTVQQYQGIFQIVLTY
 .  ||||.|||  |....| .
graasvqtlqqymliwkvlldf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 704-921 9.7e-24 78.9 In-house 55-277 (307) alignment 
Range on Protein: 704-921
Range on HMM: 55-277/307.0
NYRV--PLKGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPST----------PSGIILGEYNIKL
. |.   ..|   ||| | ..    . | || |. |. ||  .|| |. . .| ...|||.  |  .  | ||||            |  | . .  .| 
kgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakk

LSEETynGYIE-RKLEVnnNTGATAQSVTQYQITNWDSTGkvtNPQTILLVIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDV
|. .    .|.  .|.|  . .  .......| .||   |    ||. |  |. .  .. .  .  .|||||  ||||    | .   .|  . .   |.
lapde..dlinvttlkv..dwaqksrtiqhlqwenwpdrg...vpqinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdm

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 ....  | |.. ..||  ||  . ...| |.
kklveelrsqrhyaiqteaqylylhrvlleyf
0049772 (Phosphotyrosine protein) phosphatases II 701-926 2.1e-23 79.0 In-house 57-285 (314) alignment 
Range on Protein: 701-926
Range on HMM: 57-285/314.0
GADNYRVP--LKGEHPDYINAVFINGFkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVM---------------------LCHENE
.|||....  | ..  ||||| ...||   ..||... |. .|  .|          |.|.  .|.||  |||                     |.   .
padnrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildg

NNqevcyqywpstpsGI---------IlgeynikllseetyngyierklEVNNNTGATAQSVTQYQITNWDStGKVTNPQTILLVIEEMYRTqrkRGNTS
|.             ..                                |. ..     . . .|  ....  | .  .. .. ..| . .    . .. 
ng.............neptaadlellk......................eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggp

IVVHCSDTVGRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTVQQYQGIFQIVLTYLDSFEA
..|||.. .||.. |..||  . ..   || .. ..|.  | . |     |.... .||. |....| ||. .. 
vlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkk
PTPc_DSPc_SM00012 818-917 2.7e-22 74.3 In-house 2-103 (105) alignment 
Range on Protein: 818-917
Range on HMM: 2-103/105.0
VTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
|..|..|.|  .|. .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| .||. . .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IV
..
al
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 702-922 7.6e-22 72.4 In-house 60-288 (305) alignment 
Range on Protein: 702-922
Range on HMM: 60-288/305.0
ADNYRVPLKGEHP-DYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIIL-GEY----NIKLLSEE
 || || |.|  | .|| | ..    . | || ...|. .|  .|| |  . .| || |||   |   . |..|..|    ..   |      .|. | .
ldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessv

TYNGYIERKLEVN------NNTGATAQSVTQYQITNWDSTGKVTNPQTIllvIEEMYRTQRKRGntSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-
|..   . | .|.      . .|..|. ||.|   .|   |  .  ..|   .| . ...  .|   ||||||  .||.         ...  .  .|. 
tlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlai...lellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiied

VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
  ..|.  | |.  |.|| .||  . |..| |. 
tdkilqkireqrnnsiqtdaqylfvhqvilnyfr
0051082 (Phosphotyrosine protein) phosphatases II 713-915 7.7e-22 72.9 In-house 2-147 (151) alignment 
Range on Protein: 713-915
Range on HMM: 2-147/151.0
HPDYINAVFINGFkekkaFIIAESPmfntARNFWKMIDDRNVTAIVMLCHENENNqeVCYQYWPSTPsgiilgeynikllseetyngyierklevnnntg
..||||. .. |.     ...   |       |.... . ....||.|. | |..   |..|.|..                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

ataQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVQQYQG
     |....|..|. .|  ......| ..|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||. ||.. 
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

IFQ
...
qlf
0044763 (Phosphotyrosine protein) phosphatases II 712-917 1.6e-21 72.2 In-house 16-167 (178) alignment 
Range on Protein: 712-917
Range on HMM: 16-167/178.0
EHPDYINAVFINGFkekkaFIIAESPMfntaRNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSgiilgeynikllseetyngyierklevnnnt
|  |||||..| ..     ....  |.     ...... . ..|.||.|..| |.... |..|||.  .                               
ersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...............................

gataqsvTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVQQYQ
        ||. ....  |  . .. .| ..| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..  |..
.......iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlr

GIFQIV
 . .. 
qLyefe
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 699-921 2.9e-21 70.8 In-house 52-271 (288) alignment 
Range on Protein: 699-921
Range on HMM: 52-271/288.0
FPGADNYRVPLKGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKLLSEETyn
 |  |  || |. .   ||.|  .   | |. .| |..|.  |  ..|||. . .|  |||||.  |  .|   .|.||     .    . .   ..   
lprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr..

GYIERKLE----VNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLK
  |.. ..     ....| ... | .  . .||  |   | .. | ..| .     |  .  ||||.|  |||.. .      ..  . .  . . ..|.
adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirslla

SQRIQKPGSVQTVQQYQGIFQIVLTYL
. | ..  ..|| .||  ....|| .|
klreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 703-921 2.7e-20 67.5 In-house 48-270 (285) alignment 
Range on Protein: 703-921
Range on HMM: 48-270/285.0
DNYRVPLKGEHPDYINAVFIN-GFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGII-LGEYNIKLL--SEETYN
.. || ||    ||| | ..    |.. ..| .. |. .|  .||.|| . ... ..|||   |   | |  |.|     .. .|.|.| |    ||.  
eetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaia

GYIERKLEVNNNTGATAQSV--TQYQITNWDSTgkvTNPQTILLVIeEMYRTQRK--RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLK
| |   | | |   |... .   . |.  |        |.    .| |.|.  .|    .. |.||||  |||.| |     .  .   .  |.......
gtilnaltvintedasseplymnhvqvpwwpdq...lapedarpmi.elykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivr

SQRIQKPGSVQTVQQYQGIFQIVLTYL
  |  .  .||.  |.  .. ... |.
emramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 714-918 6.4e-20 66.5 In-house 46-256 (290) alignment 
Range on Protein: 714-918
Range on HMM: 46-256/290.0
PDYINAVFINgFKEKKAFIIAESPMFNT-------ARNFWKMIDDRNVTAIVMLCHENENNQE----VCYQYWPSTPS-GIILGEYNIKLLSEETYNGYI
 ||| | ..  . .  ..|. .||  ..         .|| |. . .|. .||||  .|....     | .| | .    . ..  ..|  | |. .. .
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

ERKLEVNNNTGaTAQSVTQYQITNWDSTGKVTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQK
.|.|.|. . .     || ... .|...    ...|.| .|. .     |  .| ..||| | . |||.. |      |   |.| . . .|||. | |.
tRelvvkfdde.eeftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

PGSVQTVQQYQGIFQIVL
   ... ...  .   ..
alaitsalelafvdagiv
subfamily_egg_pd Subfamily egg 686-921 6.1e-19 62.8 In-house 55-270 (307) alignment 
Range on Protein: 686-921
Range on HMM: 55-270/307.0
SRKKRQVETGMRVFpgadnyrvplkgehpDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENnqEVCYQYWPSTPSG---I
|| | ... |. .                |.| |  ..|      ||.|..|. ||  .||.|.   .|  ||||    |.  | |  ||| ..|    .
srvklelrrGqyld...............dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvt

ILGEYNIKLLSEETYNGYIE--RKLEVnnNTG-ATAQSVTQYQiTNWDSTGKVTNPQTILlvieemyRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTIN
. | ..|. |  .     .    || .    |    . .  .|  ... ...|  |  .|       |  |.   . .||.. . | ..| . |. ... 
vpGslrienlkvdskadplfrvtklkl..vGgddeerflehwq.gdvnnssdvysplrvl.......rklrnl.skpvvvqdilGvskaatlvaieiall

KCKtEGVIDVFQVLKS---QRIQKPGSVQTVQQYQGIFQIVLTYL
.    | |  . ||..    | ... ||..| .|  ....|| ..
sll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 713-921 6.5e-19 62.7 In-house 79-289 (305) alignment 
Range on Protein: 713-921
Range on HMM: 79-289/305.0
HPDYINAVFING-FKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIiLGEYNIKLLSEETYNGYIERKLEVNN--
  ||| | ..   .  .| || |. |. .|  .|| |. ...|  |||||.  |  .  | |||| .     |   .  .. . . .  .||  |..   
psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek.lelksgivvenvsgskpmerdaeiqitl

----NTGATAQSVTQYQITNWDSTGKvtnPQTILLVIEEMyRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSV
     .|    || . | |.|   |    |   |  .| .  . |   .  ||||||  .||.    |    ..|   .  .  . ...|. | |.  |.
lnltysgdqkmsvrhlqwtewpdrgv...ppckltslell.sair.gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsi

QTVQQYQGIFQIVLTYL
|.  ||  | ...| |.
qndvqylfihrvmlnyf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 726-916 1.7e-18 61.5 In-house 2-199 (199) alignment 
Range on Protein: 726-916
Range on HMM: 2-199/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGII-LGEYNIKLLSEETYNGYIERKLEVNNNTGAT--AQSVTQYQ
| .. .| .. |. .|  .||.|. .     |||.  .. |..     |||.| ||    |  ..   .  |   |    | . ||| |   .. ...||
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

ITNWDS--TGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQI
.| |    | .|.    ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.|.
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 727-916 2.2e-18 61.1 In-house 2-198 (198) alignment 
Range on Protein: 727-916
Range on HMM: 2-198/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGII-LGEYNIKLLSEETYNGYIERKLEVNNNTGAT--AQSVTQYQI
 .. .| .. |. .|  .||.|. .     |||.  .. |..     |||.| ||    |  ..   .  |   |    | . ||| |   .. ...||.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWDS--TGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQI
| |    | .|.    ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.|.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_ptpA1_pd Subfamily ptpA1 712-880 6.1e-18 59.8 In-house 73-255 (418) alignment 
Range on Protein: 712-880
Range on HMM: 73-255/418.0
EHPDYINAVFINGFKEkKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGI----------ILGEYNIKLLS--EETYNG
|  ||||| .|.|    | || .. |. ||  .||.|. .  .  |||| .|.|| .  | .|||    |           ..| |...|.   ..    
egsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpere

YIERKLEVNNNtGaTAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQ-----RKRGNTSIVVHCSDTVGRSAMFCAAATTINK
 | |.. .  . |  .. .||||   |         | .  ..  .   |         |  |.||||  |||.  ||.|   ..|
iitrnirltfe.g.etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 689-921 7.1e-17 55.8 In-house 50-285 (302) alignment 
Range on Protein: 689-921
Range on HMM: 50-285/302.0
KRQVETGMRVFPGADNYRVPLKGEHPDYINAVFINGFKEKKAFIIAESPMFNTA---RNFWKMIDDRNVTAIVMLCHENENNQeVCYQYWPST-PSGIIL
|    .    .| .|. .| |..|  .|.||  ..  . ..  |.|  |  ...    .||.|. ..... .|.|  |.| ..    ...| .  .    
knlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykey

GEY--NIKLlSEETYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
|.   |..   |.. .   .  .||  .  . .  .. | .||| ..   ..  ..   .....      .. ..|.     .|| ..| ..|....| .
gkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfak.kikadentvivSknGaGRagafltlavaveklq

TEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
..    . ...|| | |.| .|....||  .. ..|.|.
kgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_CG42327_pd Subfamily CG42327 713-844 2.6e-16 54.2 In-house 55-189 (319) alignment 
Range on Protein: 713-844
Range on HMM: 55-189/319.0
HPDYINAVFINGFKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPST---PSGIILGEYNIKLLSEETYNGYIERKLEVN
.  |..| .. |... .. .| |. .. ... .||... ...   || |.   |.  .|| .|.|.    ..    |.. . |   |. . |.   | ..
kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllk

NNTGATAQSVTQYQItNWDSTGKVTNPQTILLVIEE
.  .  .. .| |   .|  ..  ....... .. |
rvdkeesrelthywy.kwleaevPaeeaaliamlle
subfamily_hpo-7_pd Subfamily hpo-7 733-920 6e-16 53.1 In-house 42-226 (263) alignment 
Range on Protein: 733-920
Range on HMM: 42-226/263.0
IaespMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIIlGEYNIKLLSEETYNGYIERKLEVNNNTG--ATAQSVTQYQITNWDSTG
.    . .|  .|...|   . . .||||  ||...| | .|.|    .      |... . .. .  . . ||. .. |   . . |..|. . |  . 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekq.klanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekn

KVTNPQTILLVIeemyRTQRKRgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
 ..... || ..    .  |.    |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......|  |    . .||..
dpelareilnil....kvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 734-921 9.2e-16 52.7 In-house 39-221 (255) alignment 
Range on Protein: 734-921
Range on HMM: 39-221/255.0
AespmfnTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGI-ILgeYNIKLLSEETYNGYIERKLEVNNNTG--ATAQSVTQYQITNWDSTG
       |  .|...|   . . .||||  .|...| | .|.|    .  .|   .... . .. .  . | ||.  . |    .. |. |. . |    
l......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkl..advnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekn

KVTNPQTILLVieemYRTQRKRgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
   ... || .    ..  |.    |.|||||  .|||| |  |            . .| . .|  ..|.  | .......|  |    . .||...
aPelareilni....lkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtPlqlafsilmvldlv
fn3 Fibronectin type III domain 567-636 1.6e-15 50.2 Pfam-A 13-84 (85) alignment 
Range on Protein: 567-636
Range on HMM: 13-84/85.0
PTEITIAWNPPAIPNGIITVYEIRYRESTSTG-PYNITNTTNT-YYSIVGLIPNTSYTIEVRAYTSTGPGEW
.|..|. |.||. ..| || ||..|||..... . ..|.. .|  . . || |.|.|...|.|..  | |..
stsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 704-920 2.2e-15 51.0 In-house 66-289 (310) alignment 
Range on Protein: 704-920
Range on HMM: 66-289/310.0
NYRVPL---KGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKLLSEETYNGY
. || |   |  . ||| | ...    ...|| .. |.  |  .||.|| .    .|..||.  |. .  |  ||||       |   .  ||| . .  
tsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefe

IER--KLEVNNNTGATAQSVT----QYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNtsIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLK
|       | .|     |       . .. .|        |.     . .   .| . |    |||||  ..|  . .|   .|.| .    .|. .|  
icnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevkt

SQRIQKPGSVQTVQQYQGIFQIVLTY
  . ..   .||  ||  | .. . .
ellksraiciqtelqyliidrvriif
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 735-914 2.8e-15 50.5 In-house 97-281 (302) alignment 
Range on Protein: 735-914
Range on HMM: 97-281/302.0
ESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGI-ILGEYNIKLLSEE-TYNGYIERK------LEVNNNTGAT--AQSVTQYQIT
  |  .|   .| .|.. ||. .| ||.  |.... | .|.     |   .|.| .| .| .   . . ..|      .|..|.   .   ..|   . .
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

NWDSTGKVTNPQTILLVIEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
 |   |   ...| | ..   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||. ||   ..
awpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 703-927 6.7e-15 49.6 In-house 56-282 (312) alignment 
Range on Protein: 703-927
Range on HMM: 56-282/312.0
DNYRVPLKGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKL--L-----SEE
|  |  | |.   || | |..     . |.....|. ||. .||..      |.|..||   |.  | | .|     . . | .. .             
drgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggk

TYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAA---TTINKCKTEGVIDVFQV
. .    | | |  ..      . .|| . |   |     .| | ..  .     |. .  .. |||  |||.  ..      ... . . . | |.| .
skdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl

LKSQRIQkpgSVQTVQQYQGIFQIVLTYLDSFEAY
|. .| .   ||... ||   ...|| .| |   |
lrkdrar...svrvfpqyvyalrcvleflyskgly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 684-794 3.3e-14 47.4 In-house 27-142 (297) alignment 
Range on Protein: 684-794
Range on HMM: 27-142/297.0
SSSRKKRQVETGMRVFPGADNYRVPLKGEHP--DYINAVFINGFKEKK--AFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTP
|. |.    .   |     |. || |..  .  ||||| ..   .|..   .|.|. |. .|  .||... ...| .|||... .|. .. |. ||||. 
sakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

SG-IILGEYNIKLLSE
 .    |.. .. ||.
qerlkagdvvveflss
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 703-838 3.8e-14 46.9 In-house 109-242 (244) alignment 
Range on Protein: 703-838
Range on HMM: 109-242/244.0
DNYRVPL-KGE-HPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQevcyqYWP-STPSGIILGEYNIKLLSEETYNG
|  |||| ||     |||| |.  .     .|... |. .|. .||||. .| |  .|.|   .|...     ||| | |      .  . |   . .  
dfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplewyeeditvtltdrdefkn

YIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTI
    .||.. .   . |..| .||.|| | |   |   |
ikasnleiesdmneshqaltmfqisnwpsdgttpndhfi
fn3 Fibronectin type III domain 461-542 5.2e-14 45.3 Pfam-A 4-83 (85) alignment 
Range on Protein: 461-542
Range on HMM: 4-83/85.0
SDIIFSSVESVSMTVSWDEVPcnRRNGPITGYYLTYTNITSNT-SYTVNITGGDNrMYNLTGLIPYTNYTVSIIPYNYNMNGP
... .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|||| |.|.|....  .| . .||
enlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
0048076 (Phosphotyrosine protein) phosphatases II 781-918 8.3e-14 47.0 In-house 10-140 (145) alignment 
Range on Protein: 781-918
Range on HMM: 10-140/145.0
GIILGEYNIKLLSEETYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINk
|. || .   |  |.  .  | . | . ...    . ..||. ..|.  |  . ....| ..| . . ...  .  ..||||  |||.....||   .  
glylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll.

cktEGvIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
   .| ......|.  | | ||.|....|.. ... .|
...lg.vsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 747-914 9.9e-14 46.8 In-house 23-138 (144) alignment 
Range on Protein: 747-914
Range on HMM: 23-138/144.0
KMIDDRNVTAIVMLCHENENNQEVCYqywpstpsgiilgeynikllseetyngyierklevnnntgataqsVTQYQITNWDSTGKVTNPQTILLVIEEMY
... . ..|... |..| |.. . ..                                             ..||. ..|.  |  . .. .| ..| . 
ellkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefie

RTQRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVQQYQGIF
. ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|.. .|.. . 
eale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 812-920 1.5e-13 44.8 In-house 85-193 (440) alignment 
Range on Protein: 812-920
Range on HMM: 85-193/440.0
GATAQSVTQYQITNWDSTGKVTNPQTILLVIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQ
|  .... ||.   |   |       .| .|...  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| .|| 
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

GIFQIVLTY
 ... ||  
fvheavleg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 713-834 2.6e-12 41.2 In-house 12-129 (130) alignment 
Range on Protein: 713-834
Range on HMM: 12-129/130.0
HPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQevcyqYWPST-PSGIILGEYNIKLLSEETYNGYIERKLEVNNNT
  .|||| |.      . .. .. |. .|. .||||. .| |  .|.|   .|...     ||| . |      .  . |   . ..     .||.... 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikasnleiesdl

GATAQSVTQYQITNWDSTGKVTN
  . |..| .||.|| | |   |
neshqaltmfqisnwpsdgttpn
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 714-778 3.3e-11 37.5 In-house 83-153 (350) alignment 
Range on Protein: 714-778
Range on HMM: 83-153/350.0
PDYINAVFIN----GFKEKKAF--IIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPST
 ||||| ...    . . .  |  | . .|. .|  .|.|.|   .|. |..|  . |.| | ||.||.  
nDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 844-920 2.8e-10 34.6 In-house 219-294 (297) alignment 
Range on Protein: 844-920
Range on HMM: 219-294/297.0
EMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
| .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||..|.. ....||  
eslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 722-807 1.5e-09 31.7 In-house 229-311 (440) alignment 
Range on Protein: 722-807
Range on HMM: 229-311/440.0
INGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLcheNENNQEVCYQYWPSTPSGIILGEYNIKLLSEETYNGYIERKLEV
..|.  |.||| .. |.  |  .||... | ....|.||   |. |.  |  |||     . .| . .     |  |    | ||.
fegyskknafiatqmpldstvldfwrlvhdyristiiml...nqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 695-778 1e-08 28.9 In-house 85-156 (349) alignment 
Range on Protein: 695-778
Range on HMM: 85-156/349.0
GmrvfpgadnyrvplKGEHPDYINAVFI--NGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPST
                |   ||||| ..    .. .| .|    |.  |  .|.|.|   .|  .. | ...|.. | |..||   
d..............sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_CG42327_pd Subfamily CG42327 849-920 1.9e-08 28.4 In-house 242-314 (319) alignment 
Range on Protein: 849-920
Range on HMM: 242-314/319.0
QRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
 ..  .  .|||||| |||. .  |.  .|.. ..    .|. |.. | | ..  .|.|..||. |....  |
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 743-921 7.2e-08 25.4 In-house 132-309 (346) alignment 
Range on Protein: 743-921
Range on HMM: 132-309/346.0
RNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKLLSEETYNGYIERKLEVNNNTGATAQSVTQYQITNWDSTGKVTNPQTILLVI
 .|| || . ..  . ..  ..  ..     .          |   |.    .      |  .||  .  . .  .  .. . |    .  .   |. .|
edfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiikmi

EEMYrTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 ... ....  |. . |      ||.  |  |  .||.       ......|. . |.||.|..  || .|. ||. |.
hqfl.sekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 714-917 1.1e-07 25.8 In-house 69-275 (303) alignment 
Range on Protein: 714-917
Range on HMM: 69-275/303.0
PDYINAVFINGFKEKKAfIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTPSGIILGEYNIKL---LSEETYNGYIERKLEVNNN
  || | ...   .||| |... |.  || .||.|| ...|  ...|  ..| ..      .|     . . |  |..      |  .|.  . | | | 
ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsng

TGATAQSVTQYQITNWDSTGKVTNPQTIlLVIEEMYRTQRKRGNTSIVVHCS-DTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVQ
.  .   | .|.    .|    ..|. .   | ..    ||  ...  |. |   .||.  |.   |.    .  .  .|. ..|.  |  .  .|| . 
dyksflhvhhykawphnsipsdgspkfv.kqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnls

QYQGIFQIV
|.  .. ..
qfsvvytll
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 680-762 2.1e-07 24.8 In-house 35-118 (347) alignment 
Range on Protein: 680-762
Range on HMM: 35-118/347.0
EST-SSSSRKKRQVETGMRVFPGADNYRVPLKGEHPDYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
| . |    |. ..    ||    .. .     .   ||||  |.  . .| .|... |. .| |.||||.   .|| .| .  
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_eak_pd Subfamily eak 715-830 7.2e-07 22.9 In-house 79-193 (332) alignment 
Range on Protein: 715-830
Range on HMM: 79-193/332.0
DYINAVFINGFKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHENENNQEVCYQYWPSTP-SGIILGEYNIKLLSEETYNGYIERKLEVNnnTGA
 ||||  ..  .  . .|..  .  .    ||.|. ...  |||.| .. |.. |   .|.|      .  | ....  .    | .  |.||..   | 
GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllels..kGn

TAQSVTQYQITNWDSTG
 .  |  |..  |  | 
ethrvlhykvfGwtett
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 713-805 3.5e-06 20.7 In-house 59-153 (332) alignment 
Range on Protein: 713-805
Range on HMM: 59-153/332.0
HPDYINAVFINGFKEKKAFIIAESPMFN-TARNFWKMIDDRNVTAIVMLCHENENN-QEVCYQYWPSTPSGIILGEYNIKLLSEETYNGYIERKL
. |. || ...|. .| |.|.|..|. . |   ||.|. .|. . |...   .|.. ..  |.         .| |.  | | |   .  | ||.
kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksflhefgaksleecelkakicrkf