Gene PTPRD-18 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP071_AA protein Get Run
AqueP071_AA_656-940 phosphatase_domain Get Run
AqueP071_AA_954-1232 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 653-944 7.8e-104 341.6 In-house 2-288 (290) alignment 
Range on Protein: 653-944
Range on HMM: 2-288/290.0
VKLSEFADHIElLNKSNGGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRGDCSHSYINASYIDGYKKKHQFIATQGPL
.....|.....  ....| .||...|..|... . ....|...|.||..|||..|..||.| .||||||.. ||...||||.||.|||.|.|.||||||.
ipvdkfgefva.nghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

PQTLVDFWRLIWQEDICCILMMLSITSDGGiVRCQQYWPDAiGVAAfYGPFKIIVegINDNKVSEERIIKLSMTSSSSSdNSHKTIHHYLFKCWPDHG-V
..||||||.|||||....|.|...|...|  |.|||||||. ...| ||.|.| .  .|.....|....||......|. ........| ...|...| |
sntlvdFWkliwqekvtiivmltniieegk.vkCqqYWpds.dtka.ygefsikl..lneetlneyierklevknknsa.gakqsvtqyqitnwdstgkv

PATPTSTHSFYEQIK-MWLDLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYTIGK
... |......|..| .. .   ....|||...|...........|..  ..|..||.......|.|.....||..|||......|...... .
tnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 962-1237 2.7e-94 310.3 In-house 13-289 (290) alignment 
Range on Protein: 962-1237
Range on HMM: 13-289/290.0
HDEILNMNRYEAHYKALQVlTVKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKTED------FIHASYINGYQEARSFIVAESPTKLTAANFWSMI
.... .........|.|.. . ....| .... || .| |.. ....|..|..|......      .|.|.||.||.|....|....|.. |...||..|
nghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

VKNKCSVIVMLCDIVEMEVDTCYQYWPATyDSERhFDFYRIK-HHEMNIDnYYTQTILRVLDTQAGeEQTIILIQLPLSNIVSDElSHTERVGILSAIQE
...|...||||..|.|.. ..|.||||.. |... .. ..|| ..|.... .|... |.| ..... ... ...|. ..|. |.. ..|.. .||..|.|
wqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetln.eyierklevknknsa.gakqsvtqyqitnwdstg.kvtnpqtillviee

IEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEFEAY
..|.|||.||..|.|||||||.||.|||...|.|...|.|........|...|..|||...| .||.... ....|...||.|
myktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_PTPRD_pd Subfamily PTPRD 653-979 7.5e-83 274.0 In-house 5-320 (564) alignment 
Range on Protein: 653-979
Range on HMM: 5-320/564.0
VKLSEFADHIELLNkSNGGKGFKSEFQRLQNFgHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPIssRGDCSHSYINASYIDGYKKKHQFIATQGPL
.. .|...|.. |. .|..  |..|......  . |..|.|| ..||..||.. |..||..   |...  .|| .  |||||.||||.|....|||||||
ipvaelkehvaklk.ansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskv..egdegsDYINAsfidgyrkrkayIAtqgPl

PQTLVDFWRLIWQEDICCILMMLSItSDGGIVRCQQYWPDAiGvAAFYGPFKiiVEGINDNKVSEERIIKLSMtSSSSSDNShKTIHHYLFKCWPDHGVP
..|. ||||..|......| |. .. .. | |.|..|||.  |  . || ..  |.  . .....  | .... . ..|..| ...... |  |||||||
aetiedFWRmvweqnsstiVmltkl.eEkgkvkchkYWPek.g.tetygelt..Vtleeeeeladyeirtfkl.kkkksses.reVrqFhFtsWPdhgvp

ATPTSTHSFYEQIKMWLD-LPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYTiGKESITPSN
 ..||  .. .... .      |...||| |.| ||. | | . .|.  . . ||.. .|...|.||  |.||||||.|.|...|||    |..... .|
esatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac.gntevesen

LQLIVKRLGKHDEILNMNRYEAHYKALQ
|.  ...| . .|  .|  .|. .. |.
lkqhlqkLaeveedtemtgleleFqrLa
0051299 (Phosphotyrosine protein) phosphatases II 652-939 6.2e-80 264.0 In-house 4-286 (288) alignment 
Range on Protein: 652-939
Range on HMM: 4-286/288.0
YVKLSEFADHIELLNkSNGGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKKKHQFIATQGP
 ....|...... |   || .|.. ||..|... . ... .|.  ||...||.. |||||..   |.....  . ...||||||||||..|..|||||||
eisveellklvlkll.angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgP

LPQTLVDFWRLIWQEDICCILMMLSITSdGGIVRCQQYWPDaiGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGV
||.|. ||||..|.... .| |. ...   | . | ||||.  |    ||....    .  ..    | .... ..  . |. ..|..|. .. ||||||
lpntvedFWrmvweqnvrvIvmltklve.lgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

PATPTSTHSFYEQIKMW-LDLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
| .|..  .|..... .  . ..||..||| |.| ||..| . . .|| . .|||||. .|...|.||..|.||.|||.||...|||..
pdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 658-941 7e-79 260.7 In-house 28-301 (308) alignment 
Range on Protein: 658-941
Range on HMM: 28-301/308.0
FADHIELLNKSNGGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLrpissrgDCSHSYINASYIDGY--KKKHQFIATQGPLPQT
  | ..||.| .. .... ||..|...  |....||.  |||..||.| |||||..   |       | ...||||||.|||  |....|||||||||.|
vldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpnt

LVDFWRLIWQEDICCILMMLSITSdGGIVRCQQYWPDAIG-VAAFYGPFKIIVEGINDNKVSEERIIKLSMTSSSSSdnshKTIHHYLFKCWPDHGVPAT
. ||||..|.... .| |. ...   |.. | ||||. .|     ||.|.. .  .  ..    | ..|...... |    .|..|. .. |||||||  
vedFwrmvweqnvrvIvmLtklve.ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges....rtvthfhytnWpdhgvPps

PTSTHSFYEQIKMWLdLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYT
|..  .|.|... .|  ..|...||| |.| || .| . . .||   .|||||  .|.|.|.||..|.||.|||.|....||| ...
peilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0047943 (Phosphotyrosine protein) phosphatases II 663-938 1.9e-77 255.7 In-house 3-271 (273) alignment 
Range on Protein: 663-938
Range on HMM: 3-271/273.0
ELLNKSNGGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLrpissrGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRL
 ||.|..| .... ||..|... .|....||.  |||..||.| |||||..   |      || ...||||||.|||..|..|||||||||.|. ||||.
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

IWQEDICCILMMLSITSDgGIVRCQQYWPDAIGV-AAFYGPFKIIVEGINDNKVSEERIIKLSMTSssssDNSHKTIHHYLFKCWPDHGVPATPTSTHSF
.|.... .| |. ..... | . | ||||.  |     ||.|.. . ... ..    | ..|....    ..  .|..|.... |||||||....|  .|
vweqnvrviVmLtelvel.grekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg....tgesrtvthfhytgwpdhgvppslesllef

YEQIKMWLD---LPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEA
.|... .|     ..||..|||.|.| ||..| . . ..|   .|||||  .|...||||..|.||.|||.|....||| 
ielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0036941 (Phosphotyrosine protein) phosphatases II 662-941 2e-77 255.7 In-house 3-279 (297) alignment 
Range on Protein: 662-941
Range on HMM: 3-279/297.0
IELLNKSNGGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLrpissrGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWR
. ||.|...  ....||..|... .|.|..||.  ||...||.| |||||..   |      .| ...||||||.|||. |..|||||||||.|. ||||
lkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWr

LIWQEDICCILMMLSITSDgGIVRCQQYWPDAIGVAAFYGPFKIIVEGIND--NKVSEERIIKLSMTssssSDNSHKTIHHYLFKCWPDHGVPATPTSTH
..|.... .|.|. . ... | . |.||||. .|    ||.|.. . ...   ..    | .....|     .. ..|..|. .. ||||||| .|.|  
mvweqnvtvIvmltelvel.grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt....gngesrtvthfhytgwpdhgvpespasll

SFYEQIKMWLD---LPPPVLIHCSGGIGVTGMLISIMIGIEQGL---STGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYT
.|.|... .|.    ..|||.|||.|.| .|..| . . ..|      .||||.  .|.|.|.||....||.|||.|....||| ...
dfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0040438 (Phosphotyrosine protein) phosphatases II 657-943 7e-76 250.8 In-house 4-280 (317) alignment 
Range on Protein: 657-943
Range on HMM: 4-280/317.0
EFADHIELLNKSNGgKGFKSEFQRLQNFGHLfSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKKKHQFIATQGPLPQTL
.. .....|.||.  .....||..|... .  ...||.  |||..||.. |||||..   | |...  | ...||||||.||...|..|||||||||.|.
dlllalldllksdf.talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntv

VDFWRLIWQEDICCILMMLSITSdGGIVRCQQYWPDaiGVAAFYGPFKIIVEGINDnkvsEERIIKLSMTS--SssSDNSHKTIHHYLFKCWPDHGVPAT
 ||||..|......|.|. . .   | . |.||||.  |    ||.|.. . ..      .. |. . ..   .   |. . |..|. .. ||||||| .
edFwrmvweqgvtvivmLtelee.lgrekcaqYwpl..getltygdftvtllseee....lagitlrtlevedl..gdsesrtvthfhytgWpdhgvpps

PTSTHSFYEQIKMWLDL-PPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYTIG
|..  .| |... .|.  . |||.|||.|.| ||..| . . .||   .|||||  .|...|.||....||.|||.|....||| ... .
pdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
0046845 (Phosphotyrosine protein) phosphatases II 673-941 2.4e-75 248.8 In-house 1-276 (284) alignment 
Range on Protein: 673-941
Range on HMM: 1-276/284.0
GFKSEFQRLQNFGHLF--STEVANCSENKKRNRFKTILPYDNNLLTLRPISSRgDCSHSYINASYIDGY-----KKKHQFIATQGPLPQTLVDFWRLIWQ
|.. ||..|... . .  |..||.  ||...||.| |||||..   |...... . ...||||||.|||     ..|..|||||||||.|. ||||..|.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe

EDICCILMMLSITSdGGIVRCQQYWPDAiGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTsssSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQI
... .| |. ....  | . | ||||.  |    ||.|.. .  .. ..    | ..|...   . .. ..|..|. .. |||||||..|..  .|....
qnvrvIVmltelve.ngrekcaqYwple.gevltygdftvtllseevkddytvrtleltnl...gytgesrtvthfhytswpdhgvppspedlleflrlv

KMWLDL---PPPVLIHCSGGIGVTGMLISIMIGIEQGLSTG---GVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYT
. .|.    ..|...|||.|.| ||..| ... .||   .|   ||||  .|...|.||..|.||.|||.||...|||....
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0039614 (Phosphotyrosine protein) phosphatases II 656-939 1.1e-73 243.6 In-house 16-289 (297) alignment 
Range on Protein: 656-939
Range on HMM: 16-289/297.0
SEFADHIELLNKSNGGKGFKSEFQRLQNFGHlfSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRgDCSHSYINASYIDGYKK-KHQFIATQGPLPQ
 .. | . ||.| |.  ... ||..|... .  ....|.  |||..||.| |||||..   | |. .. | ...||||||.|||.. ...|||||||||.
lsvldlllllekansktllllefeellslkp..dysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpe

TLVDFWRLIWQEDICCILMMLSITSDGGivRCQQYWPDAIGvaaFYGPFKIIVEGINDNKVSEERIIKLSMtsssssDNSHKTIHHYLFKCWPDHGVPAT
|. ||||..|.... .|.|. . . .|    |.||||.  |    ||.|.. . ..  ..    | .....      ..  .|..|... .||||||| .
tvedFwrmvweqgvtvivmLtklvelgr..kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn......ngesrtvthfqytgwpdhgvpps

PTSTHSFYEQIKMWLD---LPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
...  .|.|... .|     . |||.|||.|.| ||..| . . .||  ..|||||  .|...|.||....||..||.|....||| .
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0045450 (Phosphotyrosine protein) phosphatases II 664-939 4.4e-73 242.0 In-house 19-304 (307) alignment 
Range on Protein: 664-939
Range on HMM: 19-304/307.0
LLNKSNGGKGFKSEFQRLQNFGH--LFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRgDCSHSYINASYI--------DGYKKKHQFIATQGPLP
||.. ..  |.. ||..|... .  |.....|.  |||..||.| |||||..   | ..... . ...||||||.        |||..|..|||||||||
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlp

QTLVDFWRLIWQEDICCILMMLSITSDgGIVRCQQYWPDAiGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTsssSSDNSHKTIHHYLFKCWPDHGVPA
.|. ||||..|.... .|.|. . . . | . | |||||  |    ||.|.. . ...  .    | ......   . .. . |..|. ...||||||| 
etvedFwrmlweqgvtvivmltelvel.grekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl...dgtgesrtvthfhytgwpdhgvpp

TPTSTHSFYEQIKMWLD---LPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGG---VDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
.. .. .|.|... .|.    . |||.|||.|.| ||..| . . ..|. ..|    ||.  .|...|.||....|..|||.|....||| .
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 653-961 7.9e-72 237.0 In-house 4-304 (305) alignment 
Range on Protein: 653-961
Range on HMM: 4-304/305.0
VKLSEFADHIELlNKSNGGKGFKSEFQRLQNFGHlfSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRGdcSHSYINASYIDGYKKKHQFIATQGPL
. |...| .|.  ....  ||.. ... |.. ..  |..| . ..||..||.| | ..|.. . |.. .| .   . ||||||.||||.|...|..||||
ialddlaayike.arvysdkgleaqykslyeeee..sidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPl

PQTLVDFWRLIWQEDICCILMMlSITSDGGIVRCQQYWPDAIGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTSSsssDNSHKTIHHYLFKCWPDHGVP
..|..||||||..| .  |.|. . . .||  .|.||||....    .|.|.....  .  .   || .|.|. ..   |.  .|. .| .  |||||||
kntvadfWrliveekvstivml.tklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede...dkesrtvlqyqltdWPdhGvp

ATPTSTHSFYEQIKMWLDL--PPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFyTIGKESITPS
 ..||  |......         |.|.||| |.| ||. |.. | .|.    . |||. .....||.||.|.|| .||.|.| .| |   | |. ||  |
qfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli.tcgdtsiigs

NLQLIVKRLGK
||.. |..| |
nlrarvnklkk
subfamily_PTPRB_pd Subfamily PTPRB 652-939 1.6e-71 235.7 In-house 6-285 (293) alignment 
Range on Protein: 652-939
Range on HMM: 6-285/293.0
YVKLSEFADHIELLNKSNgGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKKKHQFIATQGP
 .||..|..|.. ... .   .|. |...|...|.  ....|. ..|...||.. |||||.. . | ....  . .  ||||.||.||. ...|||||||
piklekfeehvkkmkads.dlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkd..esgsDYinanyipgynsprefiatqGP

LPQTLVDFWRLIWQEDICCILMMlSITSDGGIVRCQQYWPDAIgVAAFYGpfKIIVEGINDNKVSEERIIKLSMTSssssDNSHKTIHHYLFKCWPDHGV
||.|. ||||..|..    |.|.   . ..| |.|..|||.    . .||  .| |. ........  | .|...     .........| |. ||||||
lpetvddfWrmvwekkssiivml.tqlvekgkvkCeeYWPade.epvlyG..dikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgv

PATPTSTHSFYEQIKMWL---DLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
| ....  .| .... ..       |...||| |.| || .|..   ...  ..  ||...|| ..|..|....|||.|| |.| ..|. .
PektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0043336 (Phosphotyrosine protein) phosphatases II 656-937 6.5e-71 234.3 In-house 5-275 (278) alignment 
Range on Protein: 656-937
Range on HMM: 5-275/278.0
SEFADHIELLnKSNGGKGFKSEFQRLQNFGHlFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKKKHQFIATQGPLPQT
........ | . |. .... ||..|..| . .....|.  |||..||.| |||||...  | ....  | ...||||||.|||.....|||||||||.|
kdllkallel.llnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpet

LVDFWRLIWQEDICCILMMLSITSdGGIVRCQQYWPdaiGVAAFYGPFKIIVEGINDNKVSEERIIKLSMtsssSSDNSHKTIHHYLFKCWPDHGVPATP
. ||||..|.... .|.|. . .   | | |.||||   |    ||.|.. . ... ..    | .....      |.  .|..|| ...||||||| ..
vedFwrmvwelgvttivmLtelve.lgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn....lgdgesrtvthyhylgwpdhgvpesl

TSTHSFYEQIKMWLD-LPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
..  .|..... .|.  . |||.|||.|.| ||..| . . .||  ..||||.  .|...|.||....||..||.|....|||
sllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 654-964 1.3e-69 229.8 In-house 6-307 (319) alignment 
Range on Protein: 654-964
Range on HMM: 6-307/319.0
KLSEFADHIELLNKsNGGKGFKSEFQRLQNFGHLfSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKKKHQFIATQGPLP
.. |...... |.. .| .... ||. |.. .   ... |.  ||||.||.. ||.||.  ..| ..      .  |||||.||||.....|||||.|| 
evqeLkerlkalas.tgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqaPle

QTLVDFWRLIWQEDICCILMMLSItSDGGIVRCQQYWPDAIgvAAFYGpfKIIVEGINDNKVSEERIIKLSMtSSSSSDNSHKTIHHYLFKCWPDHGVPA
.|. ||||..|.|.. ...|.  . .. . |....|||..      ||  ..||.  .... ..  | ||..    ||.   ... |. .. ||||.|| 
ntiedfWrmvWeeessivvmltkl.veklkvklkkywpeen..feeyG..rlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPe

TPTSTHSFYEQIKMWLD--LPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFyTIGKESITPSN
. ||   ....|.   .     |. .||| |.| ||  | . . .|.    | .||  .|...| ||  |.|..|||.|....||||  ..|.  |   .
katslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav.eagdteievqd

LQLIVKRLGKHDE
|.  .|.| ... 
lrdrlkqlaekva
DSPc_SM00195 674-939 1.4e-69 229.7 In-house 2-262 (263) alignment 
Range on Protein: 674-939
Range on HMM: 2-262/263.0
FKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRgdCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILM
.| ||..|..  .  .|. |. ..||..||.| |||||..   | .. ..   ...||||.||.|..||...||||||||.|. ||||..|.|.. .|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

MLSITSDgGIVRCQQYWPDAIGVAAFYGpfKIIVEGINDNKVSeERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLD-LP
. .   . |  .|..|||. .|    .|  || |. .. .|.. . ||.  .. .   .. ......| .| ||||||| ...|. ......| . .   
lteeeen.gkekcdrywpeesggketfg..kisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

PPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
.|...||| |.| ||....| | ...  ..  ||. .||...|.||..|.||.|||.|.. ..||..
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 674-939 1.4e-69 229.7 In-house 2-262 (263) alignment 
Range on Protein: 674-939
Range on HMM: 2-262/263.0
FKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRgdCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILM
.| ||..|..  .  .|. |. ..||..||.| |||||..   | .. ..   ...||||.||.|..||...||||||||.|. ||||..|.|.. .|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

MLSITSDgGIVRCQQYWPDAIGVAAFYGpfKIIVEGINDNKVSeERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLD-LP
. .   . |  .|..|||. .|    .|  || |. .. .|.. . ||.  .. .   .. ......| .| ||||||| ...|. ......| . .   
lteeeen.gkekcdrywpeesggketfg..kisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

PPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
.|...||| |.| ||....| | ...  ..  ||. .||...|.||..|.||.|||.|.. ..||..
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 653-966 4.3e-69 228.0 In-house 2-306 (318) alignment 
Range on Protein: 653-966
Range on HMM: 2-306/318.0
VKLSEFADHIELLNKsNGGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISsrGDCSHSYINASYIDGYKKKHQFIATQGPL
........|.. |.. .|   ...|..||.   . ...  .. . ||..||.  ||.||.    |....  |. .  ||||.|||||..|...||.|.||
isvedleshvrrlre.sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmle..geegsDyinanyidGyrrkkayiaaqaPl

PQTLVDFWRLIWQEDiCCILMMLSITSDGGIVRCQQYWPDAIgvAAFYGpfKIIVEGINDNKVSEERIIKLSMTSssSSDNSHKTIHHYLFKCWPDHGVP
|.|. ||||..|. . .....||. ... | .....|||.    .  ||  |. ||  .. ..|.  . ....|   .  ....... | .  |||.|||
petieDfWrmvWeqn.savivmltqeeergkakvhryWPskg..srsyg..klvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvp

ATPTSTHSFYEQIKMWL--DLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYTiGKESITPS
. ..|  ..  |.. .       |...|||.|.| ||. | . | .|.    . |||. .|...|.||  |.|||.||.|.. |||||  . |.  .  |
esgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas.gdtevdas

NLQLIVKRLGKHDEIL
.|.  ...| ..|   
dlrsrirelreqdpes
subfamily_PTPRK_pd Subfamily PTPRK 654-961 4.6e-68 224.4 In-house 5-298 (314) alignment 
Range on Protein: 654-961
Range on HMM: 5-298/314.0
KLSEFADHIELLNKSNgGKGFKSEFQRLQNFghlfsTEVANCSENKKRNRFKTILPYDNNLLTLRPISsrGDCSHSYINASYIDGYKKKHQFIATQGPLP
.  .  ..| ||.... | ||| |.. | .       ..|.  ||...||.. ||.||. . .| .|   || |  ||||..||.||. ..||.|||||.
rvadllqsiallkrae.gygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitid..gdpssdyinaalidsykrpaafivtqgPlq

QTLVDFWRLIWQEDICCILMMLSItSDGGIVRCQQYWPDAIGVaafYGPFKIIVEGINDNKVSEERIIKLsmTSSSSSDNSHKTIHHYLFKCWPDHGVPA
.|. |||||...|. ..|.|.  .  . | |.| .|||.   |   ||..|. .   . ..    || ..  . .. . . ....... |  ||||.|| 
etvkdfWrlvydencasivmltel.vevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrv..eklargqeeirevrqfqflgWpdhdvPv

TPTSTHSFYEQIKMWLDL-PPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYtIGKESITPSNL
  |.  ..  ..|.. .    ....||| | | ||. | | | ..     | |||  .| ..||...||..|||||.|.. |.|||    |. .|  |..
satgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl.cgetaipvsef

QLIVKRLGK
. . .   .
kalylesir
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 667-941 6.4e-66 217.3 In-house 16-281 (288) alignment 
Range on Protein: 667-941
Range on HMM: 16-281/288.0
KSNGGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRGDcsHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQE
. .. .||..|.. | ....  |..... ..|.|.||.. ||||| . . |.      .    |||||||||.|||...|||||||..|. |||.|....
sarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeag..aDYinasyidgekkkkkyiatqgPladtvndfWelvyen

DICCILMMLSITsDGGIVRCQQYWPDAiGVAAFYGPFKIIVEGINDNKVSEERIIKLSmtssssSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIK
..  |.|. ..  .||  .|..||||| .    || ..... . .. .   .| . |        .... .|..| .. |||||||.  .    . .|.|
ktstivmltelv.eggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle......kkkteleitqyqylaWpdhgvPeskapllellrqvk

MWLDLP-PPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYT
.  .    |...||| |.| ||  |..   |..  ..  .||...|.|.| ||....||..||.|.. |||.  . 
vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
0045098 (Phosphotyrosine protein) phosphatases II 674-939 2.2e-65 216.1 In-house 9-272 (278) alignment 
Range on Protein: 674-939
Range on HMM: 9-272/278.0
FKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTlrpissrgdcshSYINASYIDGYkkKHQFIATQGPLPQTLVDFWRLIWQEDICCILM
...||..|   |.  . ..|.  .|...||.| |||||..                ||||||||||  ...|||||||||.|. ||||..|...| .|.|
lllefefllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

MLSITSDGgIVRCQQYWPDaiGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATP--TSTHSFYEQIKMWLD-
. . . .|  . | ||||.  |    ||.|.. .. .  ..    | ...  ...  .|.   ...|. ...||||||| .|  .|  ...|.|. .|. 
ltelvelg.rekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

-------------LPPPVLIHCSGGIGVTGMLISIMIGIEQGlsTGGVDVMAIVNKMRSQRMN-MIQTEEQYQFVHYVLLEAF
              . |||.||| |.| ||.|. ... .|.    ||||.  .|...||||.. ..|..|||.|....||| .
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
Y_phosphatase Protein-tyrosine phosphatase 698-937 2.6e-65 215.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 698-937
Range on HMM: 1-235/235.0
NKKRNRFKTILPYDNNLLTLrpiSSRGDCSHsYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITSDgGIVRCQQYWPDAIGVA
|||.||.|.|||||..   |   ..... |  ||||.|..|||.|..||||||||..|. ||||..|||.. .| |. | .   | . |.||||.. .  
nkkknRykdilpydktrvkl...kgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek.grekcaqYwpeeeees

AFYGPFKIIVEgiN-DNKVSEERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWL-DLPPPVLIHCSGGIGVTGMLISIMIG
  || .|. ..  .  .. ..| ...    ... ... ....... .. |||||||..|.|  .. .... .  .   ||..||| |.| ||......| 
ltygdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

IEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
.||  ... |||. ||...|.||..|.|..|||.|.. ..||
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 698-937 2.6e-65 215.5 In-house 1-235 (235) alignment 
Range on Protein: 698-937
Range on HMM: 1-235/235.0
NKKRNRFKTILPYDNNLLTLrpiSSRGDCSHsYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITSDgGIVRCQQYWPDAIGVA
|||.||.|.|||||..   |   ..... |  ||||.|..|||.|..||||||||..|. ||||..|||.. .| |. | .   | . |.||||.. .  
nkkknRykdilpydktrvkl...kgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek.grekcaqYwpeeeees

AFYGPFKIIVEgiN-DNKVSEERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWL-DLPPPVLIHCSGGIGVTGMLISIMIG
  || .|. ..  .  .. ..| ...    ... ... ....... .. |||||||..|.|  .. .... .  .   ||..||| |.| ||......| 
ltygdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

IEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
.||  ... |||. ||...|.||..|.|..|||.|.. ..||
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 662-941 4.2e-65 214.9 In-house 17-292 (298) alignment 
Range on Protein: 662-941
Range on HMM: 17-292/298.0
IELLNKSNGGKGFKSEFQRLQNFGH---LFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISsrGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVD
..  .|...  |...|||||..  .    ...|||. .||||.||.  |...|     |. ..  .|    |||||....||... |||||.||..|..|
laavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetved

FWRLIWQEDICCILMMLSItSDGGIVRCQQYWPDAigVAAFYGPFKIivEGINDNKVSEERIIKLSMTSSSSSdnSHKTIHHYLFKCWPDHGVPATPTST
|||....||| .| |. ..  . . .....||||    .. || ...  .  .... ..  . || .......  .......  |  |||.|||.. || 
FWrmvteedigtiVmltnl.eeldktkyhkywPde..gketygeitv..sllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsv

HSFYEQIKMWLDLPP--PVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYT
  . ......       ||...|| |.| .|  | |   .|.      |||. .|. .| .|....|||||| |.... |||. .
ldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
0040439 (Phosphotyrosine protein) phosphatases II 690-939 4.7e-64 211.7 In-house 3-246 (249) alignment 
Range on Protein: 690-939
Range on HMM: 3-246/249.0
TEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITSDgGIVRCQQY
..||.  |||..||.. |||||..   | ....     ..||||||||||. |..|||||||||.|. ||||..|...| .|.|. | .   | . |.||
ysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel.grekcaqy

WPDaiGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTssssSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLD---LPPPVLIHCSGGIGVT
||.  |    || |.. .  .. ..    | ..|...     |... |..|. .  ||||||| .. .. .|.|... .|.    . |||.|||.|.| |
wpl..ggsleygdftvtllsvevkddytvrtleltnl....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRt

GMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
|..| . . .||   ..|||.  .|...||||....|..|||.|....||| .
GtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 667-939 1.4e-63 209.7 In-house 10-276 (281) alignment 
Range on Protein: 667-939
Range on HMM: 10-276/281.0
KSNGGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRGdcSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQE
..|  .||..|.. |.. |   ... ..  ||...||.. |  ||.   .. | ..    .  ||||....|||.....||||||.|..||.||...|..
sqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

DICCILMMlSITSDGGIVRCQQYWPDAIGvAAFYGPFKIIVEGINDNKVSEERIIKLSMTSssssdNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIK
... | |.     ..| ..| .||||    .  || ...  .  .... . || .||...|     . ......  .. |||||||||..   .| ....
kvsaivmv.treieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkleres.....getreveqlaytaWPdhGvPattkellefrkevl

MWL--DLPPPVLIHCSGGIGVTGMLISIMIGIEQGLST-GGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
     .   |..|||| |.| ||  |..   ...  ..   .|| |.|...| .|. |.||  ||.||. ..|.|.
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 961-1240 2.1e-63 209.0 In-house 12-287 (287) alignment 
Range on Protein: 961-1240
Range on HMM: 12-287/287.0
KHDEILNMNRYEAHYKALQVLTVKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKC
....  . . ..  .. |. .| ....|  |   .| .. |.   |.||.|||.|... .|.| |..|.||.|.. ||.||||   || ||| .| ... 
akghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnv

SVIVMLCDIVEMEVDTCYQYWPATYDseRHFDFYRIKHHEMNIDNYYTQTILRVLDTQA-GEEQTIilIQLPLSNIVSDElSHTERVGILSAIQEIEKIQ
..|||||.  | . . |||||| .      .  |.|.  . .. . |..  |.|  ..  |..|..   |  . |  |     ||   ||  |.|  | |
taivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqv..kqyqitnWdstg.kvtepqtillvieemyktq

RKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEFEAYGNF
|| || .|.||||||| ||..||   |.|.. | |  ......| ..|  ||| . |  |||... ... |.. ||.| .|
rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_PTPRA_pd Subfamily PTPRA 667-953 7.5e-63 207.4 In-house 27-308 (330) alignment 
Range on Protein: 667-953
Range on HMM: 27-308/330.0
KSNGGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPIssRGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQE
...  | |. ||. |       . |.|.  |||..||.  ||||| . . | ..  .|  .  |||||.|||||.|..|||.|||. .|. ||||.||. 
saddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvk..eGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweq

DICCILMMLSITsDGGIVRCQQYWPDAiGVAAfYGPFKIIVEgiNDNKVSEERIIKLSMT--SSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQ
. . |.|.  .  .    .|.|||||  |. . ||  .. ||  ... . .  . |. ..  . .. ..... .. . |. ||| |||..|    .. ..
ksativmltelk.erkeekcaqywPde.Glvt.yGnirveve..detvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkk

IKMWLD-LPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEaFYTIGKESITPSNLQ
.|   .    |. .||| |.| || .| .   .|.  . . |||  .|...| || .|.||.|||.|.. |||| .|  |   .  | |.
vkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle.yylygdteldvssle
subfamily_PTPN12_pd Subfamily PTPN12 669-939 7.6e-63 207.1 In-house 5-277 (290) alignment 
Range on Protein: 669-939
Range on HMM: 5-277/290.0
NGGKGFKSEFQRLQNFG------HLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRGdcSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRL
.| . |..|||.|..        . .|||... .||.|.||.| |||||.. ..|. |..      .||||..| | ..|...||.|||||.|| ||||.
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrm

IWQEDICCILMMLSITsDGGIVRCQQYWPDAIGVAAFYGPFKIIVEgiNDNKVSEERIIKL-SMTSSsssdNSHKTIHHYLFKCWPDHGVPATPTSTHSF
||. ..  ..|.  .  . |  .|..|||.  . .  .|.|.. .|  ....|... .|.   .. .    . ..... . .. |||||||....|  ..
iweknveivvmaCrev.elgkkkCerYWpeegeeelefgefevtle..eekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllel

YEQIKMWL-DLPPPVLIHCSGGIGVTGMLISIMIG---IEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
 |...    .   |...||| |.| || .|.| .    ....  .  .||  .| ..| ||  ..||.|||..|.  ..| .
ielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0042113 (Phosphotyrosine protein) phosphatases II 692-937 8.6e-63 207.3 In-house 3-241 (245) alignment 
Range on Protein: 692-937
Range on HMM: 3-241/245.0
VANCSENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITSdGGIVRCQQYWP
||.  |||..||.. |||||...  | |...  |  ..||||||.|||. ...|||||||||.|. ||||..|...| .|.|. . .   | | |.||||
vallpenkdknrysdilpydhtrvklspdgg..dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeee.lgrvkcaqywp

DaiGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTssssSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLD--LPPPVLIHCSGGIGVTGML
.  |    || |.. . ... ..    |.......     |. .....||..  ||||||| .. .  .|.| .. .|    . |||.|||.|.| ||..
l..gesltygdftvtllseehlddytvrtlevtnl....gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtf

ISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
| . . .||  ...||..  .| ..||||....||..||.|....|||
iaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0050432 (Phosphotyrosine protein) phosphatases II 955-1235 1.4e-61 203.9 In-house 28-303 (308) alignment 
Range on Protein: 955-1235
Range on HMM: 28-303/308.0
IVKRLGKHDEILNMNRYEAHYKALQVLTVkPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLnKKTEDFIHASYINGY--QEARSFIVAESPTKLTAANFW
. . | .... |.. ..|. ...|. ... ...        | .. |.  .|| |  ||.| ... |.|.|||..||     | ||.. .|.. | ..||
vldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFw

SMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYD-SERHFDFYRIKHHEMNIDNYYTQTILRVLDTQAGEEQTIILIQLPLSNivsDELSHTERVGILSA
 |. .....|||||...||... .|.|||| ... . .... ..... .. ....||.. |.. ... ||. |.  .. .      |    ..   .|. 
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp...dhgvPpspeilldf

IQEIEKIQrktGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEFE
.....| .   ...||.||||. |.|.|.|..|.. ..|.. |. |...|... .|...|| ..|| ||. .| .|. |.. ..
lelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_PTPN6_pd Subfamily PTPN6 665-936 1.6e-61 203.0 In-house 19-294 (306) alignment 
Range on Protein: 665-936
Range on HMM: 19-294/306.0
LNKSNGGKGFKSEFQRLQN--FGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRpisSRGDCSHSYINASYIDGY--KKKHQFIATQGPLPQTLVDFW
 ..| . .||. ||..||.    .|.| . ..  |||..||.|.|||.|.. ..|.   . .   . ||||.||..   ......||||| |..|. |||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

RLIWQEDICCIlMMLSITSDGGIVRCQQYWPDAIGVAAfYGpfKIIVEGINDNKVSEERIIKLSMTSSsSSDNSHKTIHHYLFKCWPDHGVPATPTSTHS
|..|||.   | .|.    . |  .| .||||.    . ||  || |. ..... ..  . .||..   ...........| || |||||||. |    .
rmvwqensrvi.vmttkevErgkekCarYWPdeeekee.yG..kisvtnvseksladYilRelsvskk.kkkkeerevfqyhfksWPdhgvpkdpgavLd

FYEQIKMWLDLPP-----PVLIHCSGGIGVTGMLISIMIGIEQGLST---GGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLL
| |....  .        |...||| ||| || .| | | ...  ..     .|.  .|...|.||  ..|||.||.||.... 
fledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_PTPRG_pd Subfamily PTPRG 653-941 4.8e-61 201.6 In-house 1-289 (563) alignment 
Range on Protein: 653-941
Range on HMM: 1-289/563.0
VKLSEFADHIELLnKSNGGKGFKSEFQRLQN--FGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRgDCSHSYINASYIDGYKKKHQFIATQG
|...||| |.  | ...| .||. ||. ||.    . . .| ..  |||..||   |..||.   .|.|..   . .. ||||.|||||.|...||||||
vpvkefakhvasl.hadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgk.kkklDYinAnyidGyqkskafiatqg

PLPQTLVDFWRLIWQEDICCILMMLSITSDgGIVRCQQYWPDaiGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTSSS-SSD-NSHKTIHHYLFKCWPD
||..|. ||||.||..    | |.  .. . |   |..|||     .  || ...  .  .   .. .| ...  .     .. ...|.. .| .  |||
plkdtfddFWrmiWeqnvaiivmitnlver.grrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

HGVPATPTSTHSFYEQIKMWLD-LPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYT
||||  ..   .| .. .        |...||| |.| ||..| .   ..|  .   |.|  .. ..|.|| ...||||||.|.| .||||  .
hgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 666-938 5.2e-61 201.1 In-house 14-277 (287) alignment 
Range on Protein: 666-938
Range on HMM: 14-277/287.0
NKSNGGKGFKSEFQRLQNFGHLF-STEVANCSENKKRNRFKTILPYDNNLLTLRpissrgDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIW
.. .| .|||  |. |.. ..   .  ..  |.||..||.. ||..||. . |.      .. . ||||..|||||.|..||....|. .|...||.||.
ghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPmfntarnfWklid

QEDICCILMMLSITsDGGIVRCQQYWPDAIGvaAFYGPFKIIVEGINDNKVSEERIIKLsmTSsSSSDNSHKTIHHYLFKCWPDHG-VPATPTSTHSFYE
.. .  |.|.   . .     | ||||.       .|...| .   . |.   || ...  .  ........... | .  |...| |.   |.   . |
drnvtaivmlcqek.endeevcyqyWpeeks..vvlGeyniellneevnagyierklev..kn.knkagdkqqvkqyqitnWdstgkvtepqtillviee

QIKMWL-DLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEA
..|        ....||| ..| ..|.... ..|..    |..||. .....| |.....|| |||.|.  ..|| 
myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
0036941 (Phosphotyrosine protein) phosphatases II 968-1234 5.6e-61 201.8 In-house 12-280 (297) alignment 
Range on Protein: 968-1234
Range on HMM: 12-280/297.0
MNRYEAHYKALQVLTVkPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLC
..... ... |. | . . |      . ||.. |.  .|| |  ||.|..   |.|.|||..||.  | ||... |.. | ..|| |. .....|||||.
lalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

DIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMNI--DNYYTQTILRVLDTQAGEEQTIILIQLPLSNivsDELSHTERVGILSAIQEIEKIQRKT-GN
. ||..  .|.|||| . ...  .. ....  ....  ...||.. |.|.||. ||. |.  .. .      |    .    .|. |....|..... ..
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp...dhgvpespaslldfielvrkvlkllpsg

NPILVHCSDTVSRSGVFCVLYTSIQQMK---IEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEF
.|.|||||. |.|||.|..... .||..   .|..|.|.|..  .|...|| ..|. ||. .| .|. ..  .
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0047943 (Phosphotyrosine protein) phosphatases II 964-1231 9.4e-60 197.7 In-house 7-272 (273) alignment 
Range on Protein: 964-1231
Range on HMM: 7-272/273.0
EILNMNRYEAHYKALQVLTVkPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVI
. |....... ...|. |.. . .        |. . |.  .|| |  ||.|. .. |.|.|||..||.  | ||... |.. | ..|| |. .....||
kllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMLCDIVEMEVDTCYQYWPATYDS-ERHFDFYRIKHHEMNIDNYYTQTILRVLDTQAGEEQTIILIQLPLSNivsDELSHTERVGILSAIQEIEKIQRKT
|||...||..  .|.|||| . .. .  .. ..... .......||.. |.. ... ||. |.. .. .      |    .    .|. |....|.....
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp...dhgvppslesllefielvrkaleal

-GNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
 .|.|..||||. |.|.|.|..|.. ..|.. |..|...|... .|...|| ..|| ||...| .|. |.
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 966-1231 2e-59 196.7 In-house 20-286 (288) alignment 
Range on Protein: 966-1231
Range on HMM: 20-286/288.0
LNMNRYEAHYKALQVLTVKpNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNK----KTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCS
 ....... ...|. |... ...       ||.  |.  .|| |  ||.|.      . |.|.||||.||.  | ||... |.. | ..|| |. .....
ngltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

VIVMLCDIVEMEVDTCYQYWPAtyDSERHFDFYRIKHHEMNIDNYYTQTILRVLDT--QAGEEQTIILIQLPLSNIVsDELSHTERVGILSAIQEIEKIQ
|||||...||... .|.||||   ..   .. ....  .. ....||.. |.| ..    |...... ...   |.  |    .    .|. .... | .
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspellldflrlvrkal

RkTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
.  |..|..||||. |.|.|.|..|.. ..|.. |. |...|..  .|...||...|| ||..|| .|. |.
a.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 689-937 8.2e-59 193.9 In-house 19-266 (274) alignment 
Range on Protein: 689-937
Range on HMM: 19-266/274.0
STEVANCSENKKRNRFKTILPYDNNLLTLRPISSRGDcSHSYINASYIDGYKKKH-QFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITSdGGIVRCQ
..|  . . ....||.||||| .|  ..|.. ||. .   ||||| || ||....  ..|||||||.|. ||||.|.||..  |.|.  ..      .|.
dqeeldvfgsqtknryktilPnensrvllesessede.dssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklke.aneqkCa

QYWPDAIGV--AAFYGPFKIIVEGINDNKvsEERIIKLSMTSSSS--SdnshktIHHYLFKCWPDHGVPATPTSTHSFYEQIKMW---LDLP-PPVLIHC
.|.|||...  .  || ..| ||.|....  . .. ||.. ....  |      ..||..  |||| .|  ...  .. ....      . .  ||..||
vyfPdaedyeiserygdveikvekivern..dysvrklvlkylerers......vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhC

SGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
| ||| ||. |.| |.. |   .. |||. || ..| .|  |.||.|||...| .| .
saGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Ptp69D_pd Subfamily Ptp69D 668-939 1.6e-58 193.3 In-house 18-286 (307) alignment 
Range on Protein: 668-939
Range on HMM: 18-286/307.0
SNGGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRGDcsHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQED
 .   |.. |...|..     ||.|..  ||. .||.. | ..|..   |..|  . |   .|||||.| |||.|..||| |.|. .|. ||||.|.. .
rdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingked..sdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

ICCILmMLSITSDGGIVRCQQYWPDAigVAAFYGpfKIIVEGINDNKVSE--ERIIKLSMTSSSS-SDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQ
.  |  |||  ..    .|..|||.       ||  .|.|. .. .| |.  .| ...|..  .|   . .. .  | .. |.|  || ....   . ||
vtliv.mlsnlteknrkkcakYWpie..devqyg..dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieq

IK-MWLDLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
.. .      |...||| | | .|..... . ..|      ||....| ..||||  ..|  |||.|..  ||.  
vrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPN9_pd Subfamily PTPN9 667-937 2.9e-58 192.3 In-house 11-288 (297) alignment 
Range on Protein: 667-937
Range on HMM: 11-288/297.0
KSNGGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISsrGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQE
|..| .| . |.. ..|       ....   | ..||.. .| ||.  ..|  ..  .|    ||||...||||.|. ||||||||..|  ||||..|..
kekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvd..edeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeq

DICCILMMlSITSDGGIVRCQQYWPDAIGVAAFYGpfKIIVEGINDNKVSEERIIKLSMtsSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIK
..  |.|.   . . | ..|.||||.  . .| .|  .. |. ..... .. .. .| .  . . .. .... |. |  |||.||| . .|   . |...
evlvivmt.trvvergrlkcgqyWpleeessaefg..dlsvsnveveeeedykvrvlei..knvkteesrkvthfqflsWPdyGvPssaaslldvlekvr

MW------------L--DLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
                    ||...||| ||| || .|.. | ...  ..| |||.  |...|.||  .|||.|||.| .  .||
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0046845 (Phosphotyrosine protein) phosphatases II 974-1234 1.3e-57 190.7 In-house 5-277 (284) alignment 
Range on Protein: 974-1234
Range on HMM: 5-277/284.0
HYKALQVLTVKPN-SVLRNFGLSNLPLVRSDLYLPPDEYRVVLNK-----KTEDFIHASYINGY-----QEARSFIVAESPTKLTAANFWSMIVKNKCSV
 ...|. ||||.  |.     . || . |.  .|| |  ||.|.      .. |.|.|||..||        . ||..  |.. | ..|| |. .....|
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

IVMLCDIVEMEVDTCYQYWPATyDSERHFDFYRIKHHEMNIDNYYTQTILRVLDTQAgEEQTIILIQLPLSNIVsDELSHTERVGILSAIQEIEKIQRK-
||||...||...  |.|||| . ..  ... ....  .......||.. |.. ...  ..........   ..  |    ..   .|. .......... 
IVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgy.tgesrtvthfhytswp.dhgvppspedlleflrlvrellenl

TGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQ---QVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEF
 |..||.||||. |.|.|.|..|.. ..|.. |.    |...|... .|...|| ..|. ||..|| .|. |.  .
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 667-948 3.3e-57 188.8 In-house 19-287 (315) alignment 
Range on Protein: 667-948
Range on HMM: 19-287/315.0
KSNGGKGFKSEFQRLQNfGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLrPISSRgDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQE
|..  .||| ... .   |.|.  .||. .|||..||.  |..||.    | |.    |    |.||..||||.||...||.|||..... |||||...|
kastkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvql.pllen.dphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfee

DICCILmMLSITSDGGIVRCQQYWPDAigvAAFYGPFKIIVEginDNKVSEERIIK-LsmtsSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQI
||  |. ||. . .|   ....||||       ||.. .      ...| .|  .. |    |  ...  ...  . . .||| |||.  ..   .. ..
digkiv.mltnlvegekrkaekywpdk...kviyGkitvtrk...seevnteytvrtl....svvfgdnirevvqlhytswpdmgvpkytiplmnlirtv

KMWLDL-PPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYtIGKESIT
|.. .    ....||| |.| || .|..   ..|      .||  .....|..|..|.|. |||||.. .|||.|   |  ||.
kqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfv.cgdtsia
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 663-940 5.2e-57 188.1 In-house 10-278 (315) alignment 
Range on Protein: 663-940
Range on HMM: 10-278/315.0
ELLNKSNGGKGFKSEFQRLQNfGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRL
 ..||      |  ||. | .    . . ||  ..| |.||.| |||.|.. . |  |    .  . ||||||| .... . .||.||||. .. ||||.
afvnknrhtalfseefhdlpd.PdiyrqrvaretinfkknryknilPldsarvklevidd..sPdsdyinasyiksvdddkayiasqgPlkasvddfwrm

IWQEDICCILMmLSITSDGGIVRCQQYWPDAIGVAAFYGPFKiiVEGINDNKVSEERIIKLSMTSSsssDNShKTIHHYLFKCWPDHGVPATPTSTHSFY
..||..  | | ..  ..|  ..|.|||||  . .. .| .|  || .. .  ..  . || .  |   ..| .|.  . |. |||.||.   .|   . 
vlqekvttivm.vtkkqegdkikcrqywPdrkadsvefGsik..vellsleadtdgvarklvtrks...ees.rtvtqfqftewPdkGvdkqtssllkli

EQIKMWLD-LPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFY
 ..|   .    ..|.||| |.| ||..|||.  ..|   |  |||. .|...|..|. ..||||.| |.. ..|| ..
kevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
0040438 (Phosphotyrosine protein) phosphatases II 971-1235 8e-57 188.3 In-house 20-280 (317) alignment 
Range on Protein: 971-1235
Range on HMM: 20-280/317.0
YEAHYKALQVLtvKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKT----EDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVML
 . ... |. |  |...      . | .. |.  .|| |  ||.|.  .     |.|.|||..|... | ||.. .|.. | ..|| |. .....|||||
lleefedllsl..kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmL

CDIVEMEVDTCYQYWPAtyDSERHFDFYRIKHHEMNIDNYYTQTILRVLDTQAGEEQTIILIQLPLSNivsDELSHTERVGILSAIQEIEKIQRkTGNNP
.. .|... .|.||||   ... ... ..... ..  ....| . |.| |.. .|. |.  .. .      |         .|. ...... ..  ...|
teleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp...dhgvppspdllldfleavreale.dpggp

ILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEFE
.|||||. |.|.|.|...|. ..|.. |..|...|... .| ..|| ..|| ||. .| .|. |.  ..
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 672-940 9.6e-57 187.7 In-house 34-292 (319) alignment 
Range on Protein: 672-940
Range on HMM: 34-292/319.0
KGFKSEFQRLQNFGHLF-STEVANCSENKKRNRFKTILPYDNNLLTLRPISsrGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICC
. .. ||.|. . |      . ||  .|| .||.  ||..|.| . |...   |     |||||...||..| ..||.||||. || ||||.||. ... 
tklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerli..GeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

ILMMLsitsdggIVRCQQYWPDAIGVAafYGPFKIIVEGINDnkvSEERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQ---IKM
|...          .| ||||  | .   .. ||. |. ...   ..| ...    |  .  .  . |. . |. |||.|||  |.    . ..   .. 
ivllt.......kdkcsqywplkivik..eerfkvkvdsvee...taeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlts

WLDLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFY
  . . ....||| |.| ||. | . . ...      |||  .|. .| || ...|   ||.|..  ||| . 
kenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
0037934 (Phosphotyrosine protein) phosphatases II 692-937 2.6e-56 186.2 In-house 4-240 (243) alignment 
Range on Protein: 692-937
Range on HMM: 4-240/243.0
VANCSENKKRNRFKTILPYDNNLLTLrpissrGDcsHSYINASYIDGYKKkhqFIATQGPLPQTLVD----FWRLIWQEDICCILMMLSITsDGGIVRCQ
.|.  ||...||...|||||..   |      ..  ..||||..|.....   .||||||||.|. |    |||..|...| .|.|. . . . | . | 
iallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelv.Elgrekca

QYWPDAIgvaaFYGPFKIIVEGINDNKVSEERIIKLSMtssSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLDL---------PPPVLIH
||||. .     ||.|.. . ...  .    | ..|..    . |. .....||.. .||||||| .|..  .| .... ...            |||.|
qywpgev....tygdftvtllseehlddytvrtlllen...ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVH

CSGGIGVTGMLISIMIGIEQGlstgGVDVMAIVNKMRSQRMN-MIQTEEQYQFVHYVLLE
||.|.| ||.|| . . ...     |||.  .|...|.||.. ..||..||.|....|||
CsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 657-946 4.5e-56 185.3 In-house 9-294 (325) alignment 
Range on Protein: 657-946
Range on HMM: 9-294/325.0
EFADHIELlNKSNGGKGFKSEFQRLQNFGHLfSTEVANCSENKKRNRFKTILPYDNNLLTLRpiSSRGDCSHSYINASYIDGYKKKHQFIATQGPLPQTL
.. .|.|  .|..   ||  ||. | . .   . .||   |||..|||| ....|..   |   . . | |  ||||||.  .|||. |.|.| ||..|.
nlvehvek.kkaqdqdgfahefgllpsddgi.akkvamkpenkaknrfknvvaldksrvvle..tkkddpssdyinasylrddkkkdvflaaqaPltati

VDFWRLI--WQediCCILMMLSITsDGGIVRCQQYWPDAIGVAAFYGPFKIIVEGINDNkvSEERIIKLSMTSSSSsdNSHKTIHHYLFKCWPDHGVPAT
 |.|||.  |.   | ....| .  |.|  || .|||. .| .  .|.... .  |..   |.    .| .   .      .... . .. |.| ||.  
ndlWrlvldWr...csvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieei..sdyvhrvldvkqvkk..GetrsvkqfqlqswddmGvqkr

PTSTHSFYEQ-------IKMWLDLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYTiGKES
|..  |. .        ..       |.|.||| |.| ||..||.   ... .    ||..  |.|.| .| .|..| .|| ...  | ||. . |.  
patlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms.gntd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 666-939 5.1e-56 184.8 In-house 12-276 (515) alignment 
Range on Protein: 666-939
Range on HMM: 12-276/515.0
NKSNGGKGFKSEFQRLQNfGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRgdCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQ
||..    |  ||. |     ..   ||.   | |.||.| |||||.. . |  |       . |.||||| ...  . .||.|||.. .. |||||..|
nknrhttlfseefhdlpg.pniypqtvaqeeinfkknryknilPydsvrvklevindn..PhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlq

EDICCILMmLSITSDGGIVRCQQYWPDAIGVAAFYGPFKiiVEGINDNKVSEERIIKLSMTssSSSDnsHKTIHHYLFKCWPDHGVPATPTSTHSFYEQI
|..  | | ..  ..|  ..| .||||  | .  .| .|  || .  .  ..  . || ..   ..|   .|.  . |. |||.|||   .|   .  ..
envttiam.vtklkegdkikcgkyWPdkpgdsvkfGsik..velvsleactggikrkltvl..kgdd..srtvtqfhfteWPdkGvpkhtssllklikev

KMWL-DLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
|     .  |..|||| |.| ||..|||.  . .   |  |||. .|...| .|. ..||.||| |.. ..|| .
kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 673-952 6.4e-56 184.3 In-house 10-278 (283) alignment 
Range on Protein: 673-952
Range on HMM: 10-278/283.0
GFKSEFQRLQNfgHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgdcshSYINASYID---GYKKKHQFIATQGPLPQTLVDFWRLIWQEDIC
 |.  ..||       ....| ..|||. ||.. |.|.|.. . |.. |       .||||..|     ||.....|..|.|| .| ||||.....|.|.
lfrevlkrlsv..pdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

CILMMLSITSDgGIVRCQQYWPDAiGvAAFYGPFKIIVEginDNKVSEERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPAtPTSTHSFYEQIKMW-
.|.|.  .  |   ..| ||||   | .  ||.| . ..   ..  |.  |||. .   .|| .|   . || .  | . |  | .  .   .....   
aivmltklqed.lrikCsqyWPkr.G.sedyGeftvtlr...kettsnsfiikelllrvnssakstlllahyqvidWleygeqa.iinslvkfnkvislq

LDL-PPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYtIGKESITPSNL
 .    |...||| ||| |...|...  ... |.   |||.|.|. || ||| ..|| .||..|| . ||     |   |.  .|
teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqal.cgdtqiaavdl
subfamily_PTPN13_pd Subfamily PTPN13 675-940 1.5e-55 183.4 In-house 14-270 (273) alignment 
Range on Protein: 675-940
Range on HMM: 14-270/273.0
KSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgdcshsYINASYIDG--YKKKHQFIATQGPLPQTLVDFWRLIWQEDICCIL
. ||. |...  | ..||..  |||..||.. .||||.  ..|   ..       |||||.|     |.....||.|||||.|  |||...|. .   | 
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MMlSITSDGGIVRCQQYWPDAIGVAAFYGPfKIIVEGINDNKVSEERIIKLSMTSSSSSDNshKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLDLP
|. .   ..| |.|..|||.  .        .. || .. .| ..  . .| .. | |..   . . |  |  |||||||.....   |  ...   .  
mv.tlekekgkvkchrywPesknkklkvsn.rlevellkvqkldgfvvralavkdsesges..revahlnfvkwPdhgvPssaaellqfvaevrrlqtda

PPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFY
 |...||| ||| .|.||.| . ..       .||  ||.|.| ||  ..||..|| ||. ..||.. 
gPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 677-940 1.5e-55 183.7 In-house 3-256 (284) alignment 
Range on Protein: 677-940
Range on HMM: 3-256/284.0
EFQRLQNFGHLFS-TEVANCSENKKRNRFKTILPYDNNLLTLRPISsrGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMML
||.|. . |   .  . ||  .|| .||.  ||..|.| . |...   |     |||||.| ||..|...|||||||. || ||||.||. ... |... 
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerli..GeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt

sitsdggIVRCQQYWPDAIGVAafYGPFKIIVEGINDnkvSEERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQ---IKMWLDLP
         .| ||||  | .   .. ||. |. ...   ||| ...    |  .  .  ..|. . |. |||.|||  |.    . ..   ..   . .
.......kdkcsqywplkivik..eerfkvkvdsvee...seeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhr

PPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFY
 ....||| |.| ||. | . . ...      |||. .|...| || ...|   ||.|..  ||| . 
anivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 964-1233 2.4e-55 182.8 In-house 17-285 (305) alignment 
Range on Protein: 964-1233
Range on HMM: 17-285/305.0
EILNMNRYEAHYKALQVLtVKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKTE--DFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCS
.. . . .||.||.|. .  ... | ..    .   ...  .|..| ...  .....  |.| |||..||..  ..||| .| | | |.|| .||. | |
rvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvs

VIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMNIDNYYTQTILRVLDtQAGEEQTIILIQLPLSNIVsDELSHTERVGILSAIQEIEKIQRK
.||||...|| . | |.|||| .   ...|. . .. .. .  . |..  |..   . .....  ..|. | .   |.   ..   .|| |....| |.|
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisi.ededkesrtvlqyqltdWP.dhGvpqfatsllslikrvqkdqkk

TGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEE
  . |.|||||..|.|.|||...   ....| |..|...|.| ..|. ......|  ||  ..  |  ... 
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
0045450 (Phosphotyrosine protein) phosphatases II 971-1231 3e-55 183.5 In-house 30-304 (307) alignment 
Range on Protein: 971-1231
Range on HMM: 30-304/307.0
YEAHYKALQVLTVKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNK-----KTEDFIHASYI--------NGYQEARSFIVAESPTKLTAANFWSMIVK
.....| |.| .  ...      . | .. |.  .|| |  ||.|.      .. |.|.|||.        .||   | ||.. .|.. | ..|| |. .
lkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlwe

NKCSVIVMLCDIVEMEVDTCYQYWPATyDSERHFDFYRIKHHEMNIDNYYTQTILRVLDT-QAGEEQTIILIQL---PLSNIVSdelshtERVGILSAIQ
....|||||.. ||..   |.|||| . ..|  .. ....  .......|| . |.| |. . ||. |.. ..    |  .. .          .|. |.
qgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp......sfeelldfie

EIEKIQRKT-GNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQ---VNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
|..|..... ...|.|||||. |.|.|.|...|. ..|.. |.    |...|..  .| ..|| ...| ||. .| .|. ..
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 691-942 5e-55 181.4 In-house 2-245 (250) alignment 
Range on Protein: 691-942
Range on HMM: 2-245/250.0
EVANCSENKKRNRFKTILPYDNNLLTLRPISsrGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITSDGGIvrCQQYW
.||.  .||..||.  |...|.  . | . .  ||    |||||...||.... ||||||||..|..||||....|..  |.|. ...  .    ..|||
svakkpqnkeknryadiialdssrvvLekek..gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt..yhqyw

PdaIGVAAFYGpfKIIVEGINDNKVSEERIIKLSMTSSSssDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLDL--PPPVLIHCSGGIGVTGM
|  . .|  ||  .. |.  .... ..  . || ... .   ...... .. |  ||| |||.. |.   . ....   .     ||...|| |.| .| 
P..vekaekyG..dvtvsllskeefadytkrklklskak..kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

LISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYTI
 | |   .|.      |||. .....| .|.......||| ||. ..|.|  ..
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
0043336 (Phosphotyrosine protein) phosphatases II 979-1231 3.2e-54 179.6 In-house 28-277 (278) alignment 
Range on Protein: 979-1231
Range on HMM: 28-277/278.0
QVLTVKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKT----EDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEV
..|..|...      . | .. |.  .|| |  ||.|.  .     |.|.|||..||.  | ||..  |.. | ..|| |. ......||||.. ||...
ellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgr

DTCYQYWPatyDSERHFDFYRIKHHEMNIDNYYTQTILRVLDTQAGEEQTIILIQLplSNIVSDELSHtERVGILSAIQEIEKIQRkTGNNPILVHCSDT
 .|.||||   ..   .. ....  ... ...||.. |.| ... ||..|.  ..    ..  ... .     .|. .... .... . |.|.|||||. 
vkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhy..lgwpdhgvpe.slsllldflkavreale.dsngpvlVHCsaG

VSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
|.|.|.|..||. ..|.. |. |...|..  .|...|| ..|| ||...| .|. |.
vgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 959-1232 1e-53 178.1 In-house 22-290 (297) alignment 
Range on Protein: 959-1232
Range on HMM: 22-290/297.0
LGKHDEILNMNRYEAHYKALQVLTVkpNsVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKTE-----DFIHASYINGYQE-ARSFIVAESPTKLTAANFW
| ...  ........... |. |..  .         | .. |.  .|| |  ||.|. . .     |.|.|||..||    | ||..  |.. | ..||
llllekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

SMIVKNKCSVIVMLCDIVEMEVdTCYQYWPATYDserHFDFYRIKHHEMNIDNYYTQTILRVLDtqagEEQTIILIQLPLSNIVsDELSHTERVGILSAI
 |. .....|||||.. ||... .|.|||| . .    .. ....  .   ...||.. |.| .    .... .. ..   ..  |         .|...
rmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwp.dhgvppslelllefl

QEIEKIQRKT-GNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVE
.......... ...|.|||||. |.|.|.|...|. ..|.. |..|...|..  .| ..|| ..|| ||. .| .|. .. 
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_PTPN3_pd Subfamily PTPN3 678-939 3.4e-53 175.4 In-house 21-275 (280) alignment 
Range on Protein: 678-939
Range on HMM: 21-275/280.0
FQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRpissrgDCSHSYINASYI----DGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICcILM
|..|       ....|. .|| ..||.. |||||.  ..|.      . .  ||||.|.    .. .   ..|||||||..|  |||...|....  ...
feqlyrkkpglaisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss.liv

MLSITSDGGIVRCQQYWPDAIGVAaFYGPFKIIVEGINDNKvseeRIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWL-DLP
||  . . | |.| ||||.       || |.. .|  . .|     ..   .. . .. . ...|..  .  |||||||  ...  .| |...       
mlttlverGrvkChqyWPetedel.eygefsvkcekedetk....syvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgke

PPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
 ||..|||.||| ||.|| . . .    ..  | ...|| .|| ||....||..||.||   .|...
ePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 671-936 1.2e-52 173.5 In-house 14-290 (301) alignment 
Range on Protein: 671-936
Range on HMM: 14-290/301.0
GKGFKSEFQRLQNfGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICC
 ..|......|.. |.  |..|   .|||. |||| | .||.| ..|.| ..   |...||||||||||..|..|||.|||. .||||||||||||    
snkfeeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

ILMMLSiTSDGGIVRCQQYWPDAIGVAAFYGPFKIIVEGIN--D-----------NKVSEERIIKLSMTssSSSDNSHKTIHHYLFKCWPDHGV-PATPT
|.|.   . .|   .|.||||..      .|||.. .   .              ...|..  |. ..    .||.| ...  .    ||..|| .   |
ivmvtn.lkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfk..vksdksswdvlqlqvtdWpqdGvvreprt

STHSFYEQIKMWLD-LPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLL
  ..  ..|.        ||..||| ... .|. .|. ||.||  . | |||. ... .| ... ...| ||| ... |. 
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
DSPc_SM00195 998-1231 4.2e-52 172.5 In-house 28-262 (263) alignment 
Range on Protein: 998-1231
Range on HMM: 28-262/263.0
PLVRSDLYLPPDEYRVVLNKK----TEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDF
   |.  .|| |. || |.|.    ..|.|.|.||.|... ...|..  |.. | . || |....|...||||.. .| .  .|..||| . ...  |. 
sknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgk

YRIKHHEMNIDN-YYTQTILRVLDTQAGEEQTIILIQLPLSNIVsdELShTERVGILSAIQEIEKIQRKTgNNPILVHCSDTVSRSGVFCVLYTSIQQMK
...|  | ....  .... |..  ..  |....  .|    .    ..   .   .|. .....| .... ..||.||||. |.|.|.|... . .....
isvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvp.dstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskle

IEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
 |..|.| ||. ..|. .||...|  ||...|  ...|.
eekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 998-1231 4.2e-52 172.5 In-house 28-262 (263) alignment 
Range on Protein: 998-1231
Range on HMM: 28-262/263.0
PLVRSDLYLPPDEYRVVLNKK----TEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDF
   |.  .|| |. || |.|.    ..|.|.|.||.|... ...|..  |.. | . || |....|...||||.. .| .  .|..||| . ...  |. 
sknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgk

YRIKHHEMNIDN-YYTQTILRVLDTQAGEEQTIILIQLPLSNIVsdELShTERVGILSAIQEIEKIQRKTgNNPILVHCSDTVSRSGVFCVLYTSIQQMK
...|  | ....  .... |..  ..  |....  .|    .    ..   .   .|. .....| .... ..||.||||. |.|.|.|... . .....
isvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh..gvp.dstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskle

IEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
 |..|.| ||. ..|. .||...|  ||...|  ...|.
eekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
Y_phosphatase Protein-tyrosine phosphatase 1000-1228 4.7e-52 172.1 Pfam-A 5-234 (235) alignment 
Range on Protein: 1000-1228
Range on HMM: 5-234/235.0
VRSDLYLPPDEYRVVL--NKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIK
 |.  .|| |. || |  .....|.|.|.|..||.| ..||... |.| | . || |....|..|||||.. .|..  .| |||| . . . ... ....
nRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikve

HHeMNIDNYYTQTILRVLDTQ---AGEEQTIIlIQLPLSNIVsDELSHTERVGILSAIQEIEKIQrKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIE
   ... .  ....||.|. .   . .|. ..  || . |   |.   ..  ..|. |...|| . .. ..|..||||. |.|.|.|..| . ..|.. |
lk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWp.dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

QQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLM
..|....|. ..|...||....  ||...| ...
eevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1000-1228 4.7e-52 172.1 In-house 5-234 (235) alignment 
Range on Protein: 1000-1228
Range on HMM: 5-234/235.0
VRSDLYLPPDEYRVVL--NKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIK
 |.  .|| |. || |  .....|.|.|.|..||.| ..||... |.| | . || |....|..|||||.. .|..  .| |||| . . . ... ....
nRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikve

HHeMNIDNYYTQTILRVLDTQ---AGEEQTIIlIQLPLSNIVsDELSHTERVGILSAIQEIEKIQrKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIE
   ... .  ....||.|. .   . .|. ..  || . |   |.   ..  ..|. |...|| . .. ..|..||||. |.|.|.|..| . ..|.. |
lk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWp.dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

QQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLM
..|....|. ..|...||....  ||...| ...
eevdvlqivkelRkqRpgmvqsleqYiflykail
0045098 (Phosphotyrosine protein) phosphatases II 980-1233 6.1e-52 172.1 In-house 17-274 (278) alignment 
Range on Protein: 980-1233
Range on HMM: 17-274/278.0
VLTVKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVlnkkteDFIHASYINGYqeARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQ
.|.  |.... .  |.||.. |   .|| |  ||.      |.|.||||.||   . ||..  |.. |.|.|| |. .....|||||.. ||...  |.|
lllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPAtyDSERHFDFYRIKHHEMNIDNYYTQTILRVLDT----QAGEEQTIILIQL-PLSniVSDELSHTERVGILSAIQEIEKIQR------------KT
|||   ..   .. ....  .. . ..|| . |.| ..    . .|. ..  ... |      .  |..    .|.....|.. ..              
ywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwp..dhgvpslpilksflellefirealkllaslllsslllld

GNNPILVHCSDTVSRSGVFCVLYTSIQQMkiEQQVNIYEILYNMRTCKPG-LITTPVQYKMVYLLLMRYVEE
...|.|||||  |.|.|.....|. ....  |..|...|..  .|...||  .... ||. .| .|..... 
sggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0040439 (Phosphotyrosine protein) phosphatases II 995-1231 7.3e-52 171.8 In-house 10-246 (249) alignment 
Range on Protein: 995-1231
Range on HMM: 10-246/249.0
SNLPLVRSDLYLPPDEYRVVLNK----KTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPAtyDSERH
 |... |.  .||.|  ||.|.        |.|.||||.||.  | ||..  |.. | ..|| |. .....|||||.. ||..  .|.||||   ...  
enkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsle

FDFYRIKHHEMNIDNYYTQTILRVLDTqaGEEQTIILIQLPLSNIVsDELSHTERVGILSAIQEIEKIQRKT-GNNPILVHCSDTVSRSGVFCVLYTSIQ
.. ....  .... ..||.. |.. ..  .. ...   ...  ..  |         .|. |....|.....  ..|.|||||. |.|.|.|...|. ..
ygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

QMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
|.. |..|...|..  .|...|| ...| ||. .| .|....
qlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 653-941 8.2e-52 171.2 In-house 10-286 (297) alignment 
Range on Protein: 653-941
Range on HMM: 10-286/297.0
VKLSEFADhieLLNKSNGGKGFKSEFQRLqNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKKkhQFIATQGPL
. ||.||    |..|.   . |. ||. |     .... ||.   | ...|.| ||||| .  .|. . .  | .  |.|||.. |.|.  ..|.|| | 
iplsdfat...lvqknrhtdvfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnd..dpdsDyvnasfvkgnkh..rlittqmPm

PQTLVDFWRLIWQEDICCILMMLSiTSDGGIvRCQQYWPDAiGVAAfYGPFKIIVEGINDNKVSEERIIKLSMTSSsssdNSHKTIHHYLFKCWPDHGVP
..|. |||.....|..  |.|.    ...   .|..||.|  ||.. .|   .... ... .   .| ....  ..     ... .. | |  |||. |.
katvadfWamvldeqvstivmlnd.dnerdk.kcaryWsdk.gvtt.fGdvsvvllsvsereGfikrelevtkgka....karrvvkqyqfveWPdkave

A--TPTSTHSFYEQI-KMWLDLPP-PVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYT
   . .|   . ... | . .    |.|.||. |.| ||.|..|   . .   .  ||.. .|.|.| .|....||.|||.||. ..|||...
rkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
0042113 (Phosphotyrosine protein) phosphatases II 995-1231 1.5e-51 170.5 In-house 8-243 (245) alignment 
Range on Protein: 995-1231
Range on HMM: 8-243/245.0
SNLPLVRSDLYLPPDEYRVVLNKKT----EDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPAtyDSERH
 | .. |.  .|| |  ||.|.        |.|.|||..||.  . ||..  |.. | ..|| |. ......||||.. .|..  .|.||||   ...  
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslt

FDFYRIKHHEMNIDNYYTQTILRVLDTQAGEEQTIILIQLPLSNivsdELSHTE-RVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQ
.. ....  .......||...|.| ... .|....| ..         . . ..    .|.......|......|.|.|||||. |.|.|.|...|. ..
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp....dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

QMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
|.. |. |...|... .| ..|| ..|| ||. .| .|. ..
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 945-1237 1.9e-51 170.1 In-house 3-296 (298) alignment 
Range on Protein: 945-1237
Range on HMM: 3-296/298.0
ESITPSNLQLIVKRLGKHDEILNMNRYEAHYKALQVLTV----KPNSVLRNfgLSNLPLVRSDLYLPPDEYRVVLNK----KTEDFIHASYINGYQEARS
. |. ..|.  ...| . ..  .. .|.. .. |.  .     .  .| |.   .|    |   ... |  ||||.|    .  |.| ||....|..  .
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevark..penkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATydSERHFDFYRIKHHEMNIDNYYTQTILRVLDTQAGEEQTIILIQlpLSNiV
||... | . | ..|| |..... ..|||| ...|..  .. .||| .   .....  ... .. .    .... | | ...  .|...  ..   ..  
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlh..fts.W

SDELSHTERVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEFEA
.|.   ..   .|  ...... |...||.|..|.||. | ||| |..... ....|.|| | .....  .|. .||...|  ||. .| . ..... |. 
pdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd

Y
.
e
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 689-936 2.3e-51 169.4 In-house 11-261 (270) alignment 
Range on Protein: 689-936
Range on HMM: 11-261/270.0
STEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKKK-HQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITsDGGIVRCQ
.... .   .|| ||.. |||  .   .| ....  |    |||| |. |.... ...||..|||| || .|||.||.|   .|.|.  .. . |  .|.
esdlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgle.EkgrkkCe

QYWPDAIGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTsssSSDNSHKTIhHYLFKCWPDHGVPATPTSTHSFYEQIKMWLDL---------PPPVLIH
.|||   .    .   || |  ....| .  .. .| ..   .. .... . |. .. ||||||| .. |. |  . .||  ..           |.|.|
rYWpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvH

CSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLL
|| |.| ||.|| . |...   .|. |||.||....| .||...|. |||.|.. ...
csaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_PTPN14_pd Subfamily PTPN14 676-937 1.4e-48 160.4 In-house 27-294 (300) alignment 
Range on Protein: 676-937
Range on HMM: 27-294/300.0
SEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRgdcSHSYINASYIDGY--KKKHQFIATQGPLPQTLVDFWRLIWQEDICCILM
 |..|...  .   ...|.  ||...|||| .|||..| . | |       |. ||||| |      |....|..||||..|. |||...|....  |.|
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

MLSiTSDGGIVRCQQYWPDA--IGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTSSSssdnSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMW---
. . . ..|  .. .|.|.       . .| ||.. .  .| .    . .||    |.     ..|..|  .. |||||||  ...  |. |...     
lte.eeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk....eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

-------LDLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
        .  ||||.||| |.| ||.||   . |.       .|.  .....| ||| ..||  ||.||. ||..
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_PTPN23_pd Subfamily PTPN23 669-938 8.2e-48 157.7 In-house 12-279 (288) alignment 
Range on Protein: 669-938
Range on HMM: 12-279/288.0
NGGKGFKSEFQRLQNFGH--LFSTEVANCSENKKRNRFKTILPYDNNLLTLRpissrgDCSHSYINASYIDGYKK-KHQFIATQGPLPQTLVDFWRLIWQ
.|  ... .|. |..  .    .. .|    . ..||.. |||||.|  .||      .    |||||.. .      .|||||.||..|| |||.....
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

EDICCILMMLSiTSDGGIVRCQQYWPDAIGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTSSSssdnSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQI
.    | |.||  .. |  ....||| . | .  .|.... ..  .. .   ||..||.. ...      |.. |  .. ||..||||.| .   | ...
qkssviVmlls.keelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad....avksvshlqltsWpelGvPasPetllqfldev

KMWL-----DLPPPVLIHCSGGIGVTGMLISIMIGIEQGL-STGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEA
.  .      .  |...||| |.| ||..  ..  ...     | .|.. .|...| || .|.|..||..|.  . |||
esayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0041856 (Phosphotyrosine protein) phosphatases II 698-940 6.3e-47 154.8 In-house 1-172 (182) alignment 
Range on Protein: 698-940
Range on HMM: 1-172/182.0
NKKRNRFKTILPYDNNLltlrpissrgdcSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLsitsdggivrCQQYWPdaigva
|...||.. |||||...              .||||....|. .  .||||||||..|. ||.|......| .|...           . .|||      
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..........eelywp......

afygpfkiivegindnkvseeriiklsmtsssssDNSHKTIHHYLFKCWPDHGVPAtptsTHSFYEQIKMWLDLPPPVLIHCSGGIGVTGMLISIMIGIE
                                  .. ......||.  |||||||     ...... |...|. . |||.|||.|.| ||.|. . . ..
..................................ellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkk

QglstgGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFY
.     ||..  .|. .||.|..|..|..||.|....||| ..
l.....gvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_PTPN1_pd Subfamily PTPN1 674-947 1.2e-46 153.8 In-house 8-279 (290) alignment 
Range on Protein: 674-947
Range on HMM: 8-279/290.0
FKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSrgdcshSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILM
.|. .. ...  . |.|..|.  ||...||.. . |||   ..|.  .        ||||| ..  . |...| ||||||.|   ||...|...  ...|
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

MLSITsDGGIVRCQQYWPDAIG-VAAFYGPFKIIVEGINDNKVSEERIIKLSMTSSSSSDnsHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLDLP
.  .  . . ..|.||||      .  .   |. |. |. .. |. .. .| ..  .. .   ..| |. .  ||| ||| .|..  .|  ...    | 
lnkvv.ekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqe..treilhfhyttwpdfgvpespaaflkflfkvresGsls

---PPVLIHCSGGIGVTGMLI---SIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYTIGKESI
    |..|||| ||| .| ..   .... ||.   . .||.   . ..|..|. .||| .| .| .  .||   .| ..| 
sdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdss
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 958-1239 3.1e-46 152.5 In-house 4-301 (301) alignment 
Range on Protein: 958-1239
Range on HMM: 4-301/301.0
RLGKHDEILNMNRYEAHYKALQVLTVKPNSVLRNFGLSNLPLVRSDLYLppDEYRVVLNKK------TEDFIHASYINGYQEARSFIVAESPTKLTAANF
 ||.|  . . |..|..||.|.  . |...|  .   ..|   ..  ..  |. |..|..|      ....| ||||.||.|.. ||.|..| | | ..|
dlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvy..ddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdf

WSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMN-------------IDNYYT-QTILRVLDTQAGEeQTIILIQLPLSNIVS
| .|...| . |||...  |   . |.|||| .  .. .| .  .. .. .             | .    . | | .....   ..  ..|| . .   
WrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpq

DELSHTERVgILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEFEAY
| . .  |  .| .|... . |.| |  |..||||||||||||.| .  .. | | |  |.....   .|  ||| .||  || ..|  . .|..  ..|
dGvvreprt.vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

GN
.|
an
subfamily_PTPRD_pd Subfamily PTPRD 1007-1236 1.7e-45 150.8 In-house 59-286 (564) alignment 
Range on Protein: 1007-1236
Range on HMM: 59-286/564.0
PPDEYRVVL----NKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATyDsERHFDFYRIKHHEMN
. |. ||||    ...  |.| ||.|.||.. ...| .  |.. | ..|| |.  ...|.||||  ..|.. . | .|||.. . . ... . .. .| .
aYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeee

IDNYYTQTILRVldTQAGEEQTIILIQLPLSNIvSDELSHTERVGILSAIQEIEKIQrKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEI
  ..|. . ...  ... ....    |    .   |.   ..  ..|. |....... .... ||.||||  | |.|.|.|.   ....| |..|.||..
eladyeirtfkl..kkkkssesreVrqFhFtsW.PdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqy

LYNMRTCKPGLITTPVQYKMVYLLLMRYVEEFEA
. ..|. .. .. |. ||  ..  .. ... .. 
vkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1004-1238 3.3e-44 146.0 In-house 17-249 (250) alignment 
Range on Protein: 1004-1238
Range on HMM: 17-249/250.0
LYLPPDEYRVVLNKKT----EDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDtCYQYWPAtyDSERHFDFYRIKHH
 ... |. ||||.|.      |.| ||...||.| ..||.. .| . |  .|| |....| ..|||| ...|.|   . ||||.  .  ...   ... .
diialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv..ekaekyGdvtvsll

EMNIDNYYTQTILRVldTQAGEEQTIILIQLPLSNIvSDELSHTERVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNI
. ..   ||.. | .  ..| ...  |. ||   .   |     .   .|  ...... |...||.|..|.||  |.||| |..... ....|.|..|..
skeefadytkrklkl..skakkaderivrqlhfvvW.PdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdv

YEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEFEAYG
....  .|. .|. ...  || .|| ....... .| | 
fkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_CG7180_pd Subfamily CG7180 694-939 5.3e-44 145.0 In-house 38-290 (296) alignment 
Range on Protein: 694-939
Range on HMM: 38-290/296.0
NCSENKKRNRFKTILPYDNNLLTLRPISsrGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMmLSITSDGGIvRCQQYWPDA
  .||...||  ...|||.|   |. .   |. .  ||||.|.|.. ||...| |..|  .|. .||||...|.| .. . |. | |     ...|||  
lrkenreknrdvkvvPyDynRvvLekld..GeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvv.Ltktfdfak.mypsywpnk

IgvAAFYGPFKiiVEGINDNKVS--EERIIKLSMT------SSSSSDNSHKTIHHYLFKCWPD-HGVPATPTSTHSFYEQIKMWLDLP------PPVLIH
    . ||..   || .. .. .  . | .||  .           .   ...... ...|.  . ||   ..   . .....| .         ||...
s..keqygeif..veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
.| | . .|. ..| . .|.   .. |||   | ..| .| ..... |.|...  |||||.
ssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0037934 (Phosphotyrosine protein) phosphatases II 995-1230 1.2e-43 144.8 In-house 9-241 (243) alignment 
Range on Protein: 995-1230
Range on HMM: 9-241/243.0
SNLPLVRSDLYLPPDEYRVVLNKktEDFIHASYINGYqeaRSFIVAESPTKLTAAN----FWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPatyDSErH
 ||.  |   .|| |  ||.|.   .|.|.|..|...   . .|.   |.. | ..    || |. .....|||||.. ||...  |.||||   ... .
enlsknrysdilpydhsrvkleg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.t

FDFYRIKHHEMNIDNYYTQTILRVLDTQ-AGEEQTIILIQLPLSNivsDELSHTERVGILSAIQEIEKIQRK-------TGNNPILVHCSDTVSRSGVFC
.. ....  ...  ..||.. |..  ..  ......| ..        |    ..   .|. ..|. .....        ...|.|||||  |.|.|...
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp...dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

VLYTSIQQMkieqQVNIYEILYNMRTCKPG-LITTPVQYKMVYLLLMRY
..|. ....    .|...|..  .|...||  ..|| ||. .| .|. .
aaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 691-936 3.4e-43 142.5 In-house 31-274 (287) alignment 
Range on Protein: 691-936
Range on HMM: 31-274/287.0
EVANCSENKKRNRFKTILPYDNNLLTlrpISSRGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITSDgGIVRCQQYW
  |.   . |.||.  .||.|.. .    .|  |.   .|||| |. .|.....|||.|||.. |. ||||.....  . ...|     . .  .| .||
kaaeelaavkknryadvlPiddtrvl...lsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtrevee.arlkcykyw

PDAiGVAAFYGPFKIIVEGiNDNKVSEERIIKLSMTssSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLDLP------PPVLIHCSGGIG
|.   |    | . ...    |.|  |  .  | .       .  . .. . .  |||.... |  .   |  ..|  ..|        |...|.. |||
Per.evPmrvGGysvvlld.ydikePeygvralrli..dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiG

VTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLL
 .|.|..... .......| ||| |.| ..| .|  ..|.  |....   | 
rsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 664-939 4.7e-43 142.1 In-house 12-236 (392) alignment 
Range on Protein: 664-939
Range on HMM: 12-236/392.0
LLNKSNGGKGFKSEFQRLQNfGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRGDcsHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLI
...|      | .||. | .  ... . ||.   |.|.||.| |||||.. . |  |    |  . |.|||||.... .. .||.||| . .| ||||..
fveknrhsalffeefhdlpg.pdiypqtvaqkeinlkknryknilpydsarvkleviddipd..sdylnasyipsfdnekayiasqgpnaaslddfwrmv

WQEDICCILMMLSITSDGgivrcqqywpdaigvaafygpfkiivegindnkvseeriiklsmtssssSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYE
.||... | |.  .                                                       ....|.  . |  |||..||   .|   | .
fqenvttiamvtklkegd.................................................kgddartvaqfhftewPdkdvpkhtssllkfik

QIKMWL-DLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
..|    .   |..|||| |.| ||..|||   . .   |  |||. .| ..| .|  |.||.||| |..  .|| .
evkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_PTPRN_pd Subfamily PTPRN 675-938 1.3e-41 137.3 In-house 32-291 (297) alignment 
Range on Protein: 675-938
Range on HMM: 32-291/297.0
KSEFQRLQNFGHLFST-EVANCSENKKRNRFKTILPYDNNLLTLRPISSRgdCSHSYINASYI-DGYKKKHQFIATQGPLPQTLVDFWRLIWQEDiCCIL
. |.. | ..    || |||.  .| |.|| |..||||.. ..|.  .|.   .. ||||| | |   ..  .|||||||..|. |||...|..  ....
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasa..eksdyinasaildhdprapayiatqgplastvadfwqmvweqG.vvvi

MMLSITSDGGIVRCQQYWPDAiGvAAFYGPFKIIVegINDNKVSEERIIKlSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQI-KMWLDL
..|.  .. |. .|..||||  | .. |. ... .  . .   ... ... |.       .  .|.  . |  ||..||||.. |   |  .. | .   
vnltrleeegvkqckrywpde.G.sevyhiyevhl..vsehiwcddylvr.sfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr

PPPVLIHCSGGIGVTGMLISIMIGIEQGLS-TGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEA
  |...|||.| | ||. | | . ... |     .|..| ....| || ....|..|..|.  .. | 
scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
0036282 (Phosphotyrosine protein) phosphatases II 729-933 3.3e-41 136.2 In-house 3-164 (174) alignment 
Range on Protein: 729-933
Range on HMM: 3-164/174.0
SYINASYIDGYKKKHQFIATQGPLPqtlvdFWRLIWQEDICCILMMLSITSdGGIVRCQQYWPDaigvaafygpfkiivegindnkvseeriiklsmtss
.|||||..|..     .||.||||.     ||.......| ...|.|.     |...| .|||.                                    
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleeke.lglykcinywpe....................................

sSSDNSHKTIHHYLFKCWPDHGVPATPTsTHSFYEQIKMWLDL--PPPVLIHCSGGIGVTGMLISIMIGIEQGLsTGGVDVMAIVNKMRSQRMNMIQTEE
  ..  ......||.  ||||||| ...  ..|..... .|      |||.|||.|.| ||.|. ... . ..| .. ||....| ..|.||..|.||..
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QYQFVHY
||.|..|
Qyrflyy
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1011-1239 4e-41 136.1 In-house 61-288 (318) alignment 
Range on Protein: 1011-1239
Range on HMM: 61-288/318.0
YRVVLN----KKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATydSERHFDFYRIkhhEMNIDNY
 || |.    ... |.| |.||.||.. ...| | .|   |  .|| |.   ...||||| ...|   . . .|||      |...  ..   |.. .  
trvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvv...elkeeve

YTQTILRVLDTQAG-EEQTIILIQLPLSNiVSDELSHTERVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYN
... .|| .  .   ||.. .  |    .  .|| . .. ...|. .....|.|.|.|..||.||||  | | |||... . ....| |. |.....  .
lsdyvlrefkvtrteeeesrqvrqyhyts.WpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkq

MRTCKPGLITTPVQYKMVYLLLMRYVEEFEAYGN
.|. .. .. |  ||...|  |. ... .... .
lreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 673-947 1.2e-40 134.4 In-house 17-285 (307) alignment 
Range on Protein: 673-947
Range on HMM: 17-285/307.0
GFKSEFQRLQNFGHLfSTEVANCSENKKRNRFKTILPYDNNLLTLRpisSRGdCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCIL
 .. ||. | .     .  |   | | ..||.. .   |.. . ..     |  .  || | |.    | ..||..|||| .|  .|| .. ||.. ...
alvdefrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvk...fdg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvi

MMLSITsDGGIVRCQQYWPDAIGVAAFYG--PFKIIVEGINDNKVS-EERIIKLSMTSSSSSdNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWL
|.  .  . . ..|.||||   |    .|  |  | |. .  .|.. .| .|...      . .  .||.|. .. |||.||| .  ..  . | ..   
mlckvi.elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqinltainlleavrydt

DlppPVLIHCSGGIGVTGMLISIMIGIEQGLSTG-GVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYTIGKESI
.   ||..||| |.| .| ...| .  .. ..     |.  .|...||||   |||| || ..| |||| |    ||. 
n...pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelykety
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 967-1227 1.4e-40 134.0 In-house 4-262 (283) alignment 
Range on Protein: 967-1227
Range on HMM: 4-262/283.0
NMNRYEAHYKALQVLTVKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKTEDFIHASYIN---GYQEARSFIVAESPTKLTAANFWSMIVKNKCSVI
. | ...... |. |.| . ..  .    | .  | .  .| | .|| |. ...|.| |..|     |.. . .|.| || . |  .|| |. ..| . |
rvnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

VMLCDIVEMEVDTCYQYWPATyDSERhFDFYRIKHHEMNIDNYYTQTILRVlDTQAGEEQTIILIQLPLSNIvsdeLSHTERVGILSA--IQEIEKIQRK
|||  . | .   | ||||    ||  .  . .  ..    | ...  | .  ...  ..|..|    . .     |.  |   | |   .  .   |..
vmltklqedlrikCsqyWPkr.Gsed.yGeftvtlrkettsnsfiikelll.rvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqte

TGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLL
  . ||.|||| .. |..||. . .|..... |  |...... .||  ..... |  |||.|. | 
skkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 653-939 1.9e-40 133.7 In-house 2-279 (439) alignment 
Range on Protein: 653-939
Range on HMM: 2-279/439.0
VKLSEFADHIELLNKSNgGKGFKSEFQRLQNFGHLFST--EVANCSENKKRNRFKTILPYDNNLLTLRPISsrGDCSHSYINASYIDGYKKKHQFIATQG
|. .|| .|.| |.| .  . || .|. ..     ..    .|  . .. .||.| . ..|    ||. |   |     |||| ||.|| ... .|||||
vgrdefqehvekldknk.qeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeip..gvphshyinanyikGyyddklyiatqg

PLPQTLVDFWRLIWQEDICCILMMLSitsdggIVRCQQYWPDAIgvAAFYGpfKIIVEGINDNKVSEERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHG
|  .|  |||||....    |.|.        .|   .|||      ..||   |.|    . .. .  |  . .     . .  .|. .. . .|||. 
pkkettddfwrlviekktvtivmltn......lvesykywpsda..evcyg..diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdkn

VPATPTSTHSFYEQIKMWLDL--PPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
|||  .    |   |.   |     ||..||| |.| || .|.. | .||  .   ||.  ||. .| || .|.|.  || |..  .||  
vpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Ptp69D_pd Subfamily Ptp69D 1002-1232 2.1e-40 133.8 In-house 54-287 (307) alignment 
Range on Protein: 1002-1232
Range on HMM: 54-287/307.0
SDLYLPPDEYRVVLNK----KTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATydSERHFDFYRIK
..   . |..||.|.|    .. |.| ||.|.||.| ..||.|  |   |. .|| ||   .  .|||| .. |.. . | .|||     | ...   .|
yedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvk

HHEMNIDNYYTQTILRVLDTQ---AGEEQTIILIQLPLSNIVsDELSHTERVGILSAIQEIEKIQRKTgNNPILVHCSDTVSRSGVFCVLYTSIQQMKIE
  . .  ..|..  | |  ..   . .|..  ..|    .   |        |.|  |.........  . ||.||||  |.|||.|  |   .||.| |
lvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkae

QQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVE
..|.|.|.  ..|  .. |..   ||. .|  |. | .
dkvdifetvkdLrsqRnllvqsleqYvflyralldyss
0043147 (Phosphotyrosine protein) phosphatases II 727-933 3.7e-40 132.8 In-house 4-155 (172) alignment 
Range on Protein: 727-933
Range on HMM: 4-155/172.0
SHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSItsdggivrcqqywpdaigvaafygpfkiivegindnkvseeriiklsmt
.. ||||||.|.| . ..||||||||. || ||||......| .|... .                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

sSSSSDNSHKTIHHYLFKCWPDHGVPaTPTSTHSFYEQIKM--WLDLPPPVLIHCSGGIGVTGMLISIMIGIeqglstGGVDVMAIVNKMRSQRMNMIQT
     .. .... .||.  ||||||| ..    .|.|.|.    |.   |||.|||.|.| ||.|. . . .       |...  .|. .|..|....|.
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqn

EEQYQFVHY
..||.|..|
psqyrflyy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 697-938 3.9e-40 132.5 In-house 6-239 (239) alignment 
Range on Protein: 697-938
Range on HMM: 6-239/239.0
ENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKK-KHQFIATQGPLPQTLVDFWRLIWQEDICCILMMlSITSDGGIVRCQQYWPDAIg
 || .||.  |. || . . |  .|   |    ||||||.  |    . .||||| .  .  ||||..|||  | |.|. .   .|   .|.|||||.  
vnkaknryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivml.tglieghkkkchqywpdst.

vaAFYGPFKIIvegINDNKVSEERIIKLSMTSsSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQI-KMWLDLPPPVLIHCSGGIGVTGMLISIMI
  . |  ...    .   .|  . ||.  . |    .   . ...| |  |||.|||   |.   .  .| |  |    | .|||| |.| || .. |  
..skycnlrvt...lrktevfadyiirtfvms.qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

GIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEA
 . |      ||..  |. .| .|  |.|| ||| |.|  .|||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_PTPRA_pd Subfamily PTPRA 1006-1230 4e-40 132.7 In-house 68-294 (330) alignment 
Range on Protein: 1006-1230
Range on HMM: 68-294/330.0
LPPDEYRVVLNKK----TEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATydSERHFDFYRIKHHEM
|| |  ||.|..|    . |.| ||.|.||.|  .|| |  | . |  .|| || . | . |||| .. | . . |.||||        .   |.. ...
lPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGnirvevede

NIDNYYTQT--ILRVLDTQAGEEQTIILIQLPLSNIVSDELsHTERVGILSAIQEIEKIQRKTGNnPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNI
.. . ||    ... |  .. |... .. |. .       .  .| .|.|. .....|....... || ||||  | |.| |.|| . ....| |..|..
tvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv.PfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdv

YEILYNMRTCKPGLITTPVQYKMVYLLLMRY
.|.. ..|. .| .. |  ||...|  |. |
fefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPN23_pd Subfamily PTPN23 1002-1234 4.1e-40 132.4 In-house 49-283 (288) alignment 
Range on Protein: 1002-1234
Range on HMM: 49-283/288.0
SDLYLPPDEYRVVLNKKTEDFIHASYINGYQ-EARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHE
|   || |. ||.|.....|.| ||....    . .||.. .| . |.. ||.|....| |||||| .  |..   . .|||.  .   .|. ...  ..
srdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlks

MNIDNYYTQTILRVLDTQAGEEQTIILIQLPLSNIVSDELSHTERVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQ-VNI
 .  ... . .|..   .| . ... ..||     .    |  . . .| ....  . ...  . |..||||  | |.|||...|. ..... ..  ..|
vretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldi

YEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEF
 ...  .|. .   . .  |.|..|   ...... 
iqvvsrlreqRrfmvqekeqlkfsyeavleaarrv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1007-1236 7.7e-40 131.9 In-house 59-288 (319) alignment 
Range on Protein: 1007-1236
Range on HMM: 59-288/319.0
PPDEYRVVLN----KKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSErhFDFYRIK-HHEM
. |  ||||     ..  |.| ||.|.|||| . || . .| . |  .|| |. ....|..|||...||     . .||| .   |  .  . ..  .| 
aydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfee..yGrlivtleeee

NIDNYYTQTIlRVlDTQAGEEQTIILIQLPLSNIVSDELsHTERVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYE
. ..|  . .  . .....| .|  . .    .   ..   ..  ..|  ...|.| ..|| . || ||||. | | | |.||   ....| |. .....
eledyiirkl.kl.nkkssevetRevkhfqyteWpdhdv.PekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfs

ILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEFEA
.  ..|| .. .. .| |||..|  |. .|| ...
tvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 693-937 8.5e-40 131.4 In-house 3-239 (239) alignment 
Range on Protein: 693-937
Range on HMM: 3-239/239.0
ANCSENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKK-KHQFIATQGPLPQTLVDFWRLIWQEDICCILMMlSITSDGGIVRCQQYWP
|.   || .||.  |. || . . |  .|   |    ||||||.  |    . .||||| .  .  ||||..|||  | |.|. .   .|   .|.||||
akkrvnkaknryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivml.tglieghkkkchqywp

DAIgvaAFYGPFKIIvegINDNKVSEERIIKLSMTSsSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQI-KMWLDLPPPVLIHCSGGIGVTGMLI
|.    . |  ...    .   .|  . ||.  . |    .   . ...| |  |||.|||   |.   .  .| |  |    | .|||| |.| || ..
dst...skycnlrvt...lrktevfadyiirtfvms.qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgafl

SIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
 |   . |      ||..  |. .| .|  |.|| ||| |.|  .||
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 696-937 5.6e-39 128.8 In-house 1-237 (237) alignment 
Range on Protein: 696-937
Range on HMM: 1-237/237.0
SENKKRNRFKTILPYDNNLLTLRPISSRgdcsHSYINASYIDGYKK-KHQFIATQGPLPQTLVDFWRLIWQEDiCCILMMLSITSDGGIVRCQQYWPDAI
|||| .||.  |  || . . |.   |       ||||.|..|.    ...||.||||  .  |||...|||  | ...||.   .|  ..| .|||.. 
senkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqek.csvivmltgliegnelkchkywpstd

GvAAFYGPFKIIVegINDNKVSEERIIKLSMTsSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKM---WLDLPPPVLIHCSGGIGVTGMLIS
   | || . . .    ... |.  .  | ..    . .  . || | | .|||.|||   ..   |  .|      .    | .|||| |.| ||... 
q.paaygvltvsl..kkkeefsdytvrsllls.krltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflv

IMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
|   . |      ||.   |  .  .|  .|||..|| |.| ..||
idamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN3_pd Subfamily PTPN3 1005-1229 1.4e-38 127.4 In-house 50-273 (280) alignment 
Range on Protein: 1005-1229
Range on HMM: 50-273/280.0
YLPPDEYRVVLNKKTEDFIHASYINGY----QEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFdFYRIKHHE
 || |. || |.. . |.| |.|.|      .    .|..  | . ||..|| |. ..|.|.|||| ..||     |.|||| | |. ..   ...| ..
ilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleyg.efsvkcek

MNIDNYYTQTILRVLDTQAGEEQTIILIQLplsNIVSDELSHTERVGILSAIQEIEKIqRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIY
 . .. |    | . |... ||..|. .|       .|.   ..   .|. .....|. |.. ..|..||||  . |.||. .| |... . ....|.. 
edetksyvlrelvlkdketkeerkilqlqy...laWpdhgvPddsadflefvervrkl.rsgkeePvvvhCsaGigrtGvlilletalalieaaepvypl

EILYNMRTCKPGLITTPVQYKMVYLLLMR
.|. .||  .  |. |. |||.|   ...
divrtmrdqramlvqtasqykfvCeailk
subfamily_PTPRG_pd Subfamily PTPRG 1016-1232 2.4e-38 126.7 In-house 72-288 (563) alignment 
Range on Protein: 1016-1232
Range on HMM: 72-288/563.0
NKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPAtyDSERHFDFYRIKHHEMNIDNYYTQTILRVL
.||. |.| |.||.||| .. ||..  | | |.  || ||  .. ..|||. ..|| .   | .|||.  |   ...  ...  | ..  .||.  | . 
kkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlvik

DTQAGEEQT----IILIQLPLSNIvSDELSHTERVGILSAIQEIEKIQRKTgNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKP
...  ...        .|   ..   |  . .  .  |. ..  .. ....   ||.||||  |.|.|...|| | ..|.. |..||....|  .|. ..
nlklkkkkqcdteklvrqyhytkW.PdhgvPehslpvLifvkkssaankae.aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRn

GLITTPVQYKMVYLLLMRYVE
 |..|  ||  ..  |.  . 
flvqteEqYiflhdalleaia
subfamily_PTPN12_pd Subfamily PTPN12 1006-1232 3e-38 126.4 In-house 50-278 (290) alignment 
Range on Protein: 1006-1232
Range on HMM: 50-278/290.0
LPPDEYRVVLNKKT----EDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEM
|| |. ||.|.|..    .|.| |..|.| ..  ..| | .|   |  .|| || . . ...||.| .||..   | .||| . ..| .|. .... .| 
lPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleee

niDNYYTQTILRVLDTQAGEEQTIIlIQLPLSNIVsDELSHTERVGILSAIQEIEKIQRkTGNNPILVHCSDTVSRSGVFCVLY---TSIQQMKIEQQVN
  ..   . ..| |  .| .|. ..  |.   .   |    .    .|. |......|. . ..|..||||  | | |. ...    . ... ||.....
..kavdddflirtLkveaqkesrkv.yqfhYtaWP.DhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeld

IYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVE
..... ..|. .. |. |  ||..||  .. .|.
vfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 673-937 4e-38 125.9 In-house 7-257 (267) alignment 
Range on Protein: 673-937
Range on HMM: 7-257/267.0
GFKSEFQRLQNFGHLFST-EVANCSENKKRNRFKTILPYDNNLLTLRPISSRgdcshsYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCI
 .. ||. ...  .  ||      ..|..|||.   ||||.. . ||           ||||||..|||.|..||.||.|| .|  ||. .| ....  |
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

LMMlSITSDGGIvrcQQYWPDAIGVAAFYGpfKIIVEGINDNKVSEERIIKLSMTSSSssdNSHKTIHHYLFKCWPdHGVPATPTSTHSFYEQIKMWLDL
 ..  ..  . |   ...||  .| |  |    . ||   ...  . .|| | .       .| . .  | .| |    .   |     |    |  |. 
vll.tkvftdni...rlfwPPkmgqakkyq..dltvehslekeendyqiitlelkfkn...esahnvtlyyykkwn.intnnkpylkplfgilaknqlen

-PPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
  .|....|| |.| .| .. |   .|.    | .|.   . |.||||. ...| |.| ..| .| |
gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_PTPN9_pd Subfamily PTPN9 1009-1233 8.9e-38 125.0 In-house 55-292 (297) alignment 
Range on Protein: 1009-1233
Range on HMM: 55-292/297.0
DEYRVVLNKK----TEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMNID
|| ||||.|.    . |.|.|....||.. ..|| .  | | |  .|| |.  ... ||||   .||.    | |||| . .|  .| ...... |..  
detrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveee

NYYTQTILRVLDTQAGEEQTIILIQL--------PLSNIVSDELSHTERVGILSAIQEIEK-IQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQ
. |....| . ... .|.....  |.        | |     .. .. |    .|..|. .  . .. . ||.||||  . |.| |. |  ...... ..
edykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg

QVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEE
.|.. | .  .|| .   | || ||.. || .. |  |
tvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 972-1232 2e-37 123.7 In-house 9-260 (267) alignment 
Range on Protein: 972-1232
Range on HMM: 9-260/267.0
EAHYKALQVLTVKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVE
|  .. .. .. . . .   ..  |    | |  || |. ||.| .|.|..| |||..||.  . ||| . | | | ..|. .| ..|..|||.|  . .
ekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft

mevDTCYQYWPATYDSERHFDFYRIKHHEMNIDNYYtQTILRVLDTQAGEEQTIILIQLPLSNIVSDELSHTER-VGILSaiqeieKIQRKTGNNPILVH
   |   ..||      ....   ..|   . .| | | |   |  .    . . |      || ...  . .  .|||.      | | . ||.|..|.
...dnirlfwPPkmgqakkyqdltvehslekeendy.qiitlelkfknesahnvtlyyykkwnintnnkpylkplfgila......knqlengnrPlvva

CSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVE
||| | ||| | |... ....| |. ..|.. | ..|  ..||. |  .|  .. ||  | |
csdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_CG7180_pd Subfamily CG7180 967-1231 3.4e-37 122.7 In-house 11-290 (296) alignment 
Range on Protein: 967-1231
Range on HMM: 11-290/296.0
NMNRYEAHYKAL--QVLTVKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNK----KTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKC
....... || .  .. ... .    . .. |.   |    .|.|  ||||.|    ...|.| |.|....   . .|| | |.| |  .||... ....
krrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeei

SVIVMLCDIVEMEVdTCYQYWPATYdserHFDFYRIKHHEMNIDNY--YTQTILRVLDT----------QAGEEQTIILIQLPLSNI-VSDELSHTervG
| .|.|..  ...   . .||| .     ....  |  . .. ..|   ..  ...  .             |. .. |.||   ..  .  || .   .
savvvLtktfdfak.mypsywpnks....keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstn...a

ILSAIQEIEKIQRKT----GNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
..  .. ......|.     ..|..|..|| .|||||.. .  .......|..|...| .  .|  .|.|. .  .|| .| .|  .|
lielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0051429 (Phosphotyrosine protein) phosphatases II 729-941 3.5e-37 123.9 In-house 5-227 (272) alignment 
Range on Protein: 729-941
Range on HMM: 5-227/272.0
SYINASYIDGYKK---KHQFIATQGPLPQTLVDFWRLiWQEDICCILMMLSITSdGGIVRCQQYWP----------DAIGVAAFYGPFKIIVEGINDNKV
.||||....|| .   .. .....|||| |  ||||| ....| .|... | .   | . | .|||          |      .|| . ...  .    .
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeE.rgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

SEERIIKLSMTSSSSSDnshKTIHHYLFKCWPDHGVPATPtsthsFYEQIKMWLDlPPPVLIHCSGGIGVTGMLISIMIGIeQGLS-TGGVD--------
   | . |....| .      ...|...  |||||||  .     . | ... || . |||.|||.|.. ||... . . . .|.| .  ||        
yilrellltlllsagea...revmhlhytdwpdhgvpqea.....llellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnly

VMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYT
. ..|...|.||....||||||.|.. .|||....
leeaveelraqrpgavqteeqylflyeallellrs
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1001-1233 3.5e-37 122.9 In-house 25-266 (270) alignment 
Range on Protein: 1001-1233
Range on HMM: 25-266/270.0
RSDLYLPPDEYRVVLNKKT----EDFIHASYINGYQE-ARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYR
|.   ||  . ||.|.. .      .| | |..|...  ...| | .|.. |  .|| ||...| . |||. ...|   . | .||||  ... .. .  
RyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgk

IKHHEMN--IDNYYTQTILRVLdtQAGEEQTII---LIQLPLSNIVSDELSHTERVGILSAIQEIEKIQRKTGNN-PILVHCSDTVSRSGVFCVLYTSIQ
||   ..   .. | .| ||.   . |||. ..     . |   ....| | ..   .|. .... . .... .. |.|||||. | |.|.. .| . ..
ikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavr

QMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEE
 .. ...|.. .|. ..|  .. |. .|.||...|  .. |.| 
lLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
0049772 (Phosphotyrosine protein) phosphatases II 690-942 4.1e-37 124.0 In-house 38-283 (314) alignment 
Range on Protein: 690-942
Range on HMM: 38-283/314.0
TEVANCSENKKRNRFKTILPYDnNLLTLrPISSRGDcsHSYINASYIDGYkkkHQFIATQGPLPQTLVDF----------WRLI--WQEDICCILM----
. ||.  .|...||.. |||.| |.  | |  .  .  ..||||||.||.    .||||||||. |.|||          ||..  .. ..  | |    
ilvadlflnrdknryldilpad.nrvil.pglpvsg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------MLSITSDGgivrcqqywpdaigvaafygpfkiivegindNKVSEERIIKLSmtsSSS--SDNSHKTIHHYLFKCWPDHGVPaT
                  |...  |                               |  .....  |    .     .   ... .||   .||...| .
vladelsrLdaAlgKtpllildgng...............................neptaadlellk...eelydpelferlgikylripvpDgsap.l

PTSTHSFYEQIKMWlDLPPPVLIHCSGGIGVTG--MLISIMIGIEqglstgGVDVMAIVNKMRSQRM-----NMIQTEEQYQFVHYVLLEAFYTI
.    .|.| |. . | . |||.||..|.| ||  ... ...         ||..  ... .|..|.     ..|.. |||.|....|||.. ..
ledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll......gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 680-937 5.7e-37 121.9 In-house 36-281 (290) alignment 
Range on Protein: 680-937
Range on HMM: 36-281/290.0
RLQNF--GHLFSTEVANCSENKKRNRFKTILPYDNNlltlRPISSRGDcSHSYINASYIDGYKkkHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSI
.|. .  .. .  .. .   . |.||.| .   |      | | . |     |. | |..| |    || |||.| .| .|.||.. ||..  | |.  .
klkpylpvqylerkifdkntefkknrykdvvcndkt....rvilkdGy.dGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlcel

TSDGgIVRCQQYWPDAIGVAAFYGPFKIIVEgINDNKvsEERIIKLSMTSSS-SSDNSHKtIHHYLFKCWPDHGVPatpTSTHSFYEQIKMWLDLPPPVL
  ||   .|.||.|.  | .  .| . ..    .|.|  ...|||  ..     |  .|| ..|.  |.|||. |.    || ..   ...   .. || 
iedG.kakceqyypekeGevltfGeitvlcs.eeddk..daniikktlsvrdkdsGkehk.lkhlkikswpdksva...lstlallrtlrilrkasGpvv

IHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
.||| ||| || ...| .|..  |    .|.. .|  .|  |.| .| . ||  .  .||.
vhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_PTPRK_pd Subfamily PTPRK 1005-1225 6.1e-37 122.1 In-house 52-271 (314) alignment 
Range on Protein: 1005-1225
Range on HMM: 52-271/314.0
YLPPDEYRVVLNKKTE----DFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPAtyDSERhFDFYRIKHHE
 |..|  ||.|    .    |.| |..|..|. .. |||.  | . | ..|| .. ...|. |||| ..||     |..|||   |.|  ..  ...  |
ilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe..dtev.ygdikvelve

MNIDNYYTQTILRVLDTQAGEEQTIILIQLPLSNIVSDELShTERVGILSAIQEIEKIQRKtGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIY
..... . . |.||  .. | |.. .. |.   .  . .   ... |.|. .....| | . .. .|.||||    |.|.|... . .. .. |. |...
tellaelvvrifrveklargqeeirevrqfqflgWpdhdvP.vsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvf

EILYNMRTCKPGLITTPVQYKMVYL
..  ..|. |. .. |  |||..| 
navktlrsrkvnmveteeqykfiyd
0046846 (Phosphotyrosine protein) phosphatases II 725-937 1.5e-36 121.1 In-house 9-171 (176) alignment 
Range on Protein: 725-937
Range on HMM: 9-171/176.0
DCSHSYINASYIDGYKkkhqFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITsDGGIVRCQQYWPDAIGVAAfygpfkiivegindnkvseeriikls
| . .||||..|.|..    .||||||||.|| ||........| ....... . . | ..| .|||.  ..                            
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteev.elgrlkcpnywpeleklgi..........................

mtsssssdnshktihHYLFKCWPDHGVPATpTSTHSFYEQIKMWLDLPPPVLIHCSGGIGVTGMLISIMigieqGLS-TGGVDVMAIVNKMRSQRM-NMI
               .||.  |||||||   .  ....|.|. .|.   |||.|||.||| ||.|. .       |    |..|  .. ..|.||. ...
...............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgav

QTEEQYQFVHYVLLE
||.|||.|.....|.
qtpeQyrflyefell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1010-1233 1.7e-36 120.8 In-house 55-278 (281) alignment 
Range on Protein: 1010-1233
Range on HMM: 55-278/281.0
EYRVVL----NKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPaTYDSERHFDFYRIKHHEMNIDN
  ||..    ..|. |.| |....||.. . .|....|   . ..|| |....| |.|||.   .| .   |..|||   .|| ..  ...|... .  .
atrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeeka

YYTQTILRVlDTQAGEEQTIIliQLPLSNIvSDELSHTERVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIE-QQVNIYEILY
 | .  ... ... ||....   ||   .   |    ..   .|.  .|..|...|  . |...|||  | |.|..  | . ..... | ..... ... 
tyierkfkl.eresgetreve..qlaytaW.PdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavva

NMRTCKPGLITTPVQYKMVYLLLMRYVEE
..|  .  .. | |||. ||. .......
elrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 995-1231 2.7e-36 120.1 In-house 46-279 (288) alignment 
Range on Protein: 995-1231
Range on HMM: 46-279/288.0
SNLPLVRSDLYLPPDEYRVVLNK----KTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERH
 | .  |    || || || |.|    ...|.| ||||.|... . .| . .|   |  .|| ..  || | |||| ..|| .  .| .|||.. . ...
vnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpkny

FDFYRIKHHEMNIDNYYTQTILRVldtQAGEEQTIIliQLPLSNIVSDELShTERVGILSAIQEIEKIQRKTgNNPILVHCSDTVSRSGVFCVLYTSIQQ
 ..  .  .. . ... ....| .   . ..| .|   |.     . ..        .|  .. ..  . .   .||.||||. | |.|.| .| . |..
Gsvtvtlveskeledfvlrkllle...kkkteleit..qyqylaWpdhgvP.eskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalida

MKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
.. |..... ... ..|  .. |. |  ||  .|  |.  .
veeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 670-939 3.9e-36 119.3 In-house 20-287 (305) alignment 
Range on Protein: 670-939
Range on HMM: 20-287/305.0
GGKGFKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLrpissRGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDIC
| .|...||. .. |  .   .    ......||.| .   ||| . |     .|   | || | |.    . ..|| || || .|  ||| . .|. . 
gpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl.....egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkve

CILMMLSITsDGGIVRCQQYWPDAIG-VAAFY-GPFKIIVEGINDNKV-----SEERIIKLSMTSSSSSDNSHKtIHHYLFKCWPDHGVPATPTSTHSFY
 |.|.  .  . |  .|..|..   . |  |  .  ||.|     ...     .. .. .  ..   .  ...| . || .  ||| ||||. ..   . 
aifmlcnll.ekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekark.vthyhwidwpdrgvpaadlailell

EQIKMwldLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVD-VMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
|. .    .  |. .||| ||| || .. .   ..| |.   ..    |..|.| || | |||..|| ||| |.|. |
ekarp...skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_PTPRB_pd Subfamily PTPRB 1006-1233 5.1e-36 119.2 In-house 61-287 (293) alignment 
Range on Protein: 1006-1233
Range on HMM: 61-287/293.0
LPPDEYRVVL----NKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEM
|| |. || |    .....|.| |.||.||.  | ||..  |   |  .|| |. ..|.|.|||| ..||     | .||||....  . |      .| 
lpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaee

NIDNYYTQTilrvLDTQAgEEQTIILIQLPLSNIVSDELShTERVGILSAIQEIEK-IQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIY
. ... ...    |  .  |...  . |.     .  .    .   .|. ...... |.... ..||.||||  | |.|.|  | . .|... |. |.|.
eledwvire....lkiek.ekeerkvrqyhftsWpdhgvP.ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdif

EILYNMRTCKPGLITTPVQYKMVYLLLMRYVEE
 |....|. .  |. |  || ...  .......
givaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPN6_pd Subfamily PTPN6 949-1233 7.5e-36 118.7 In-house 6-299 (306) alignment 
Range on Protein: 949-1233
Range on HMM: 6-299/306.0
PSNLQLIVKRLGKHDEILNMNRYEAHYKALQVLTVKpNSVLRNFG--LSNLPLVRSDLYLPPDEYRVVL---NKKTEDFIHASYINGYQ--EARSFIVAE
.....  |..| |..| |. . .| ....||   .| . . |. |   .|    |    || |. ||.|   . . .|.| |.||.. .  . .|.| ..
akeieqrvselekeeeslekagfeeefeelqqeeak.kllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatq

SPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERhFDFYRIKHHEMNIDNYYTQTILRVLD-TQAGEEQTIilIQLPLSNiVSDEL
   . | ..||.|...... ||||.   ||   . |..|||.. ..|. .  ..... . .  ..|.   |.|   ....||...  .|.   .   |. 
gclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerev..fqyhfks.WPdhg

SHTERVGILSAIQEIEKIQRKTG---NNPILVHCSDTVSRSGVFCVL---YTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEE
  ...  .|. ...... |...    . ||.||||. . | | | |.      |.. ... ...|...   .|. . ||. |  |||.||  .  |.|.
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1006-1233 2.4e-35 116.9 In-house 38-270 (274) alignment 
Range on Protein: 1006-1233
Range on HMM: 38-270/274.0
LPPDEYRVVLNKK-----TEDFIHASYINGYQE-ARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDS---ERHFDFyRI
|| .. ||.|...       ..| | || ||.|  . .. .  |   | |.|| || .....||||| .. |.. . | .|.| . |    ||. |.  |
lPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdv.ei

KHHEMNIDNYYTQTILRVLDTQAgeEQTIILIQLPlsnIVSDELSHTERVGILSAIQEIEKIQRKTGNN--PILVHCSDTVSRSGVFCVLYTSIQQMKIE
| ....  | |. . | .. ..   |.... .  .      |. |  .   .|. ..|.|. .... ..  |..||||  . | |.|     ...|.. |
kvekiverndysvrklvlkyler..ersvkhywyt...dWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlree

QQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEE
. |.. .|  |.|  . |.. |  ||....  |. |...
ivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1007-1231 3.3e-34 113.5 In-house 59-288 (325) alignment 
Range on Protein: 1007-1231
Range on HMM: 59-288/325.0
PPDEYRVVLNKKT----EDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLcDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMN
. |. ||||. |      |.| |||.. ...   |. | .|   |  ..| ...  .|||.|.| .... . | | .|||      ..|   ..|   ..
aldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl.neldlgkdrcavywpkemgksktfGglevklrtie

IDNYYTQTILRVLDTQAGEEQTIILIQLPLSNIVSDELSHTERVGILSAIQEIE-KIQR-KTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIY
    | . .| | ... || ...   ||   . .  .   .  . ||  ..... ...    .  |||||||. | |.|||  ||. ....  | .|.|.
eisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdif

EILYNMRTCKPGLITTPVQYKMVYLLLMRYV
. . ..|  .| .. |  || ..|  |. ..
gfvkklrkdrpsmvetvdqyiliyealveay
0049260 (Phosphotyrosine protein) phosphatases II 735-933 4.8e-34 112.6 In-house 1-144 (152) alignment 
Range on Protein: 735-933
Range on HMM: 1-144/152.0
YIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITSdGGIVRCQQYWpdaigvaafygpfkiivegindnkvseeriiklsmtsssssdns
.||||.....|||||||.|.|| ||||.... .| .|.|. . .   | . | ||.                                            
fidgyampfefiatqgpgpntladfwrmlkelgittivmltelle.lgklkceqyi............................................

hktihHYLFKCWPDHGVPATPTSTHSFYEQIKM-WLDLPPPVLIHCSGGIGVTGMLISIMIGIeqglstGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHY
     .||.  |||||||  .     ... |.  .||   |||.|||.|.| ||.|. . . .       ||..  .|. .|..|........|..|...
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPN1_pd Subfamily PTPN1 1006-1228 1.2e-33 111.1 In-house 42-268 (290) alignment 
Range on Protein: 1006-1228
Range on HMM: 42-268/290.0
LPPDEYRVVLNKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYD-SERHFD--FYRIKHHEMN
 | |  |..|...  |.| || ..  .  ||.|..  |   |.. || |. ..|.  .|||  .|| |   |.||||   . .|  ..   ...|  . .
spydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvklisee

IDNYYTQTILRVLDTQAGEEQTIILIQLPLSNIVSDELSHTERVGILSAIQEIEKIQRKTGnnPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQ---VNI
. .|||  .|.. . .. | ..|.       .  .   | .  .  |  ..|   .... |  | ..|||  . ||| ||.. | . ... ...   |.|
rksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvG..pavihcsaGiGrsGtfclvdtclvliekkddlssvdi

YEILYNMRTCKPGLITTPVQYKMVYLLLM
 . | ..|  . ||| |. | .. || ..
kkvllelrkyrlGliqtadqlrfsylail
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 996-1230 1.4e-33 111.1 In-house 44-276 (315) alignment 
Range on Protein: 996-1230
Range on HMM: 44-276/315.0
NLPLVRSDLYLPPDEYRVVL----NKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHF
| .  | .  || |. ||.|    ..  .|.| ||||..... ...| .  | | .  .||.|....| . |||. .  | .   | ||||       .|
nfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvef

DFYRIKHheMNIDNYyTQTILRVLDTQAGEEQTIIlIQLPLSNIvSDELSHTERVGILSAIQEIEKIqRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQM
  ....   ....   |... | | |. .||.  .  |  . .   |. .  .   .|  |.|.    ... . ..|||||  | |.||.. .   ..|.
Gsikvel..lslead.tdgvarklvtrkseesrtv.tqfqftew.PdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqi

KIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRY
| .. |...... |.|. .| |. |  .| ..|  .. .
krtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1003-1231 3.2e-33 110.1 In-house 58-284 (297) alignment 
Range on Protein: 1003-1231
Range on HMM: 58-284/297.0
DLYLPPDEYRVVLNKKTE----DFIHASYINGYQEarSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVdTCYQYWPATYDSErhfdFYRIKH
   || |  || |.   .    |.. ||...|...   .|  . | | | |.|| |..... |.|||| |  | .   | .||. .  ..    |  .  
kniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt....fGdvsv

HEMNIDNYyTQTILRVLDTQAGE-EQTIILIQLPLSNIVSDELSHT-ERVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQ
  . ...  .  | | |. . |.  .. .. |    .  ...  .  .   .|  |.|..|   .. ..|.||||.  | | ||.. .   . ..| |..
vllsvser.eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakreke

VNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
|.|....  .|  .| |. |  |||.|| ... ..
vdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1018-1229 1.9e-32 107.9 In-house 51-253 (284) alignment 
Range on Protein: 1018-1229
Range on HMM: 51-253/284.0
KTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCdivemeVDTCYQYWPATYDSErhFDFYRIKHHEMNIDNYYTQTILRVldT
   |.| ||.|.|||    .| .  | . | |.|| || . .|| ||.|        | | ||||   . .   . ...| . ..  . |.   ...  .
efsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik..eerfkvkvdsveeseeyvvrdiel..s

QAGEEQTIILI-QLPLSNiVSDELSHTERVGILSAIQEIEKIQRK-TGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLIT
. |.|. |  | |  .     |       . ..  .. ......|  ....|.||||  | |.||. || . ...|| |.||..|... ..|  .. |. 
edgkekdirkirqfhflg.wpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvq

TPVQYKMVYLLLMR
  ||||..|  |. 
dlvqykfiysalle
0051429 (Phosphotyrosine protein) phosphatases II 1019-1234 3e-32 107.7 In-house 3-228 (272) alignment 
Range on Protein: 1019-1234
Range on HMM: 3-228/272.0
TEDFIHASYINGYqeaRS------FIVAESPTKLTAANFWSMiVKNKCSVIVMLCDIVEMEVDTCYQYWP----------ATYDSERHFDFYRIKHHEMN
... |.|....||    .      .. .  |..||||.|| .  ......||.|.. .|.. . |..|||           ... .  . ..|...... 
lsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee

IDNYYTQTILRVLDTQAGEEQtIILIQLPLSNIVSDELSHTErvgILSAIQEIEKiqrktgNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVN----
. ..|. . |..  .   .|    . .|   ... .   . .   .|...... .      ..|.|||||  ..|.|....|. .....  |. |.    
llldyilrellltlllsagea.revmhlhytdwpdhgvpqea...llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll

----IYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEF
    ..|..  .| . || . |. ||...|  |. .....
tnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1017-1229 5e-32 106.5 In-house 86-289 (319) alignment 
Range on Protein: 1017-1229
Range on HMM: 86-289/319.0
KKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCdivemeVDTCYQYWPATYDSErhFDFYRIKHHEMNIDNYYTQTILRVld
.   |.| ||...|||    .| |  | . | |.|| || . .|| ||.|        | | ||||   . .   . . .| . ..  . |.   ...  
eefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik..eerfkvkvdsveetaeyvvrdiel..

TQAGEEQTIILI-QLPLSNiVSDELSHTERVGILSAIQEIEKIQRK-TGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLI
.. |.|. |  | |  .     |       . ..  .. ......|  ....|.||||  | |.||. || . ...|| |.||..|... ..|  .. |.
sedgkekdirkitqfhflG.wpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlv

TTPVQYKMVYLLLMR
   ||||..|  |. 
qdlvqykfiysalle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 728-943 7.3e-32 105.5 In-house 59-274 (285) alignment 
Range on Protein: 728-943
Range on HMM: 59-274/285.0
HSYINASYIDG-YKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLsITSDGGIVRCQQYWPDAIGVAAFYGPFKIIVEGINDNKVSEERIIKLSMT
. || ||..    | .  .|.||||||.|| |||..|.|| |. .||.     .||. .|  |.|. .|    .| ..| .   ... ..   .  |...
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlc.tlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvi

SSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLDLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEE
 .  . .    . |     |||.  |        .|. .|       |. .||| |.| |  .. |     . .    .... || .||. |.. .|.  
ntedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshm

QYQFVHYVLLEAFYTIG
|. |.. ||.| |   |
qflflyvvlmeyfigeg
subfamily_ptpA1_pd Subfamily ptpA1 674-894 1.2e-31 104.9 In-house 23-251 (418) alignment 
Range on Protein: 674-894
Range on HMM: 23-251/418.0
FKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPISSRGdcSHSYINASYIDGYKKKhQFIATQGPLPQTLVDFWRLIWqEDICCILM
 | ||. |..      |   .   |  .||.  ||| .   . |. |  .      |||| ||||   | |||.||||||.|. ||||..| |. | |..
ikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdke..gsdyinanyidgaypk.qfictqgplpntiadfwrmvw.enrcriiv

MLSITSDGGIVRCQQYWPDAIGVAAF--YGPFKII-----VEGINDNKVSEERIIKLSMTSSssSDNSHKTIHHYLFKCWPDHGVPATPTS----THSF-
|||  |.   ..|..|||. ||   |  ||  . .     || ..  .  |  ||   .  .   .   . | .| .. |||| .|          ||  
mlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirlt..fegetrditqyqyegwpdhnipdhtqpfrqllhsit

--YEQIKMWLDLPPPVLIHCSGGIGVTGMLISIMI
   .||    |   |...||| |.| || . . .|
nrqnqiipssdrnvpiivhcsagvgrtgtfctavi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1006-1231 2.6e-31 103.5 In-house 48-277 (287) alignment 
Range on Protein: 1006-1231
Range on HMM: 48-277/287.0
LPPDEYRVVLNKKTE---DFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATyDSERHFDFYRIKHHEMN
|| |. ||.| ...|   |.| | |. .|..  .||.| .|   |  .|| ...... ......   ||     ||.|||   .       | .   . .
lPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldyd

-IDNYYTQTILRVLDTQAGEEQtiILIQLPLSNIVSDELSHTeRVG----ILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQV
  .  |.   ||..| .. | .  .. || | .. .. |. |  ||    .|.  | ||  .  ..  |..||..  . |||..  ... .....   .|
ikePeygvralrlidletrear..vvkqldllswPdkvlaPt.avglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrv

NIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
..  ..  .|  . .|. ..||....|  |. | 
dvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 697-944 2.9e-31 103.2 In-house 54-294 (305) alignment 
Range on Protein: 697-944
Range on HMM: 54-294/305.0
ENKKRNRFKTILPYDNNLLTLRPISsrgdcSHSYINASYIDGY-KKKHQFIATQGPLPQTLVDFWRLIWQEDICCILmMLSITSDGGIVRCQQYWPDAIG
 .. .||.. .   |.... |   |        || | |.      ...||..|||| ||. .|| .. |. .  |. ||  | . | ..| |||| | |
iaitknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqiv.mlcktvelgklkcaqywpaaqg

VAAFYGpFKIIVEGINDNKVSE-ERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKmwlDLPPPVLIHCSGGIGVTGMLISIMI
         |.|| .  .|  | .  |....   . | . . .. |  .  ||| |||    ..  .   |.       |...||| ||| || ...|  
eklelk.sgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair...gskvpivvhcsagigrtgtivaiey

GIEQGLSTGGVDVM-AIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYTIGK
 .|.      .  |  .|. .| ||   ||.. || |.| |.|. |    |
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1005-1228 7e-31 102.3 In-house 58-276 (315) alignment 
Range on Protein: 1005-1228
Range on HMM: 58-276/315.0
YLPPDEYRVVL----NKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATydsERHFDFYRIKHHE
 .. |. || |    |..  |.. |..|.||.  | .| |..|   .  .|| .. ..... |||| ..|| |   . .|||     .  .  . . . .
iiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrks

mniDNYYTQTILRVLDTQAGEEqTIILIQLPLSNIVSDELSHtERVGILSAIQEIEKIQRKTGnNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIY
   ....|.   | | .  |..    ..|| ..     ....   . ..  |. . . . ..   .|.||||. | |.| |. | . ..|...|. ...|
...eevnteytvrtlsvvfgdn.irevvqlhytswpdmgvpk.ytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvy

EILYNMRTCKPGLITTPVQYKMVYLLLM
... ..|  . ... .  ||...|  |.
nfitgvrqnrikmvqvaeqyqfiydall
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 670-938 1.2e-30 101.6 In-house 17-270 (288) alignment 
Range on Protein: 670-938
Range on HMM: 17-270/288.0
GGKGFKSEFQRLQNFGHLFSteVANCSENKKRNRFKTILPYDNNLLTLRpissrgDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDIC
. .| | |..   | .   .  . .  .|  |.|.. .   |   . |       | .. ||.|  .   | |...| .| ||  |.  .|... ..|. 
aveglkkeyrdspneasidi..idsfianptrdryenlprcditrvkls......ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdve

CILMMLSITSdGGIVRCQQYWPDAIGVAAFYGPFkiiVEGINDNKVSEERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIkmwL
 |.|.  .    |  . ..|.|  .| .| .| .      . ....  ....|.|.   |   . .. . .  .. |.|.|||    |   . | .    
yivmlcelle.kGkeksaeyfPsklGekarigrl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl...k

DLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEA
.|  |...|.| |.| || || |.| .|.  ..  . .  ...|.| .|.. |||| || .|| ..|| 
slqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1001-1229 3.4e-30 99.6 In-house 48-274 (515) alignment 
Range on Protein: 1001-1229
Range on HMM: 48-274/515.0
RSDLYLPPDEYRVVL----NKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRI
|    || |  || |    ..  .|.. ||||....  ...| .  | | .  .||....... . |.|. .  | .   | .|||       .|  ...
ryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikv

KHHEMNIDnyyTQTILRVLDTQAGEEqTIILIQLPLSNIvSDELSHTERVGILSAIQEIEKIQRKTGnNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQ
.   .. .   |..| | |    |.. .  . |  . .   |. .  .   .|  |.|.   . .    |...|||  | | ||.. .   . ..|  . 
elvsleac...tggikrkltvlkgdd.srtvtqfhfteW.PdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrm

VNIYEILYNMRTCKPGLITTPVQYKMVYLLLMR
|...... |.|  .| |. |  || ..|  .. 
vdvfnfvtnirqkrpylvqtqeqyafiygavle
0036282 (Phosphotyrosine protein) phosphatases II 1020-1224 3.6e-30 100.3 In-house 2-163 (174) alignment 
Range on Protein: 1020-1224
Range on HMM: 2-163/174.0
EDFIHASYINGYQEARSFIVAESPTKltaanFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPAtydserhfdfyrikhhemnidnyytqtilrvldtqA
.|.|.||.....   . .|.   |..     || |. .......|||.. .|..   |..|||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................l

GEEQTIILIQLPLSNIVSDELSHTERvgILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKiEQQVNIYEILYNMRTCKPGLITTPVQ
 |  .   ||.   ... ..   ..   .|......|... . ...|.|||||  |.|.|.....|  ..... |  |....... .|...|| ..|| |
redlerlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YKMVY
|. .|
yrfly
subfamily_PTPN14_pd Subfamily PTPN14 1005-1232 6e-30 99.3 In-house 58-297 (300) alignment 
Range on Protein: 1005-1232
Range on HMM: 58-297/300.0
YLPPDEYRVVLNK---KTEDFIHASYINGY--QEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERH--FDFYRIK
 || .. || |.    .....| || |.     . ||.||| .| .||  .|| |.  .. ..|||| .. |   . ...|.| . .....  |. ... 
vlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvt

HHEMNIDNYYTQTILRVLDTQAGEEQTIILIQL---PLSNIVSDELSHTERVGILSAIQEI--EKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMK
 .  .  . .. | |..    ..||.|.. .|    |  .. .|  .  . .  . ....   .... |  . |.|||||. | |.||  .    |. ..
tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatle

IEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVE
 .....| ..|  .|. .  |. |  |||.|| .|..|..
hneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0051082 (Phosphotyrosine protein) phosphatases II 729-936 7.6e-30 98.9 In-house 4-150 (151) alignment 
Range on Protein: 729-936
Range on HMM: 4-150/151.0
SYINASYIDGYkkkhqFIATQGPLPqtlvDFWRLIWQEDICCILMMLSITSDGgivRCQQYWPDAIgvaafygpfkiivegindnkvseeriiklsmtss
.|||.||..|.     .....|||.    ||..|.....| .|... | .  |    | .|.|..                                   
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg...ycpeylpelg..................................

sssdnshKTIHHYLFKCWPDHGvpaTPTSTHSFYEQIKMWLDL-PPPVLIHCSGGIGVTGMLISIMIGIeQGlstggVDVMAIVNKMRSQRMNMIQTEEQ
        ...|. .  |||.|   .|.|.... | ... ||  . |||.|||.|.| ||.|. ... . .|     |.. .... .|..|....|...|
.......ievlhipildwpdpg...lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqq

YQFVHYVLL
..|....||
flfqlfall
0041856 (Phosphotyrosine protein) phosphatases II 1007-1230 8.3e-30 99.1 In-house 12-170 (182) alignment 
Range on Protein: 1007-1230
Range on HMM: 12-170/182.0
PPDEYRvvlnkkTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCdivemevdtCYQYWPatydserhfdfyrikhhemnidny
|.|  |        |.|.|... |.. |. ||..  |.. | |.|. |. ......||.|.         ...|||                        
pydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp........................

ytqtilrvldtqagE---EQTIILIQLPLSNIVSDElshtervgILSAIQEIEKIQRktGNNPILVHCSDTVSRSGVFCVLYTSIQQmkieqQVNIYEIL
              |    . | ...||       .        . .... ||....   ..|.|||||  |.|.|.....|  ...     .|...|..
..............ellerlgiqylylpwpDhgvpd........ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeav

YNMRTCKPGLITTPVQYKMVYLLLMRY
  .| ..|| ..|| || ...|.|. .
klvrsrRpgmvitpnqyfflqlallel
0044763 (Phosphotyrosine protein) phosphatases II 721-936 1.5e-29 98.3 In-house 11-168 (178) alignment 
Range on Protein: 721-936
Range on HMM: 11-168/178.0
SSRGDCSHSYINASYIDGYkkkhQFIATQGPlpqtlVDFWRLIWQEDICCILMMLSITSDGgIVRCQQYWPDAIGvaafygpfkiivegindnkvseeri
. .| ..  |||||.|...     ......|     .|...|.....| .|... . .  |  . | .|||.  |                         
nleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelg.flkcdpywpeeag.........................

iklsmtsssssdnshktiHHYLFKCWPDHGVPATPTSTHSFYEQIKMWL-DLPPPVLIHCSGGIGVTGMLISIMIGIEQglstgGVDVMAIVNKMRSQRM
                   .||.  .||||||  .  .. |.| |. .| . . |||.||| |.| .|.|. . . ...     |... .... .|..|.
..................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp

nMIQTEEQYQFVHYVLL
 ......|....... |
.ivpnpgqlrqLyefel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 674-937 4.3e-29 96.1 In-house 13-267 (281) alignment 
Range on Protein: 674-937
Range on HMM: 13-267/281.0
FKSEFQRLQNFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRpISSRGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILM
|| ||  |          | |   |.|.||.  |   |   . |. .      |  || | ||     |. .| ||||  .|  ||||.||||.  .|.|
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlk.vkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

MLSITsDGGIVRCQQYWPDAIGVAAFYGPFKIIVEGINDNKVSEERIIKLsmtsssSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWldLPP
.  .. .    .| .|.|    ..  .  . .  |    ||      ..|      | .   . | |.|.| |||  || .         .|.      |
lcqfl.etnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl......syegetrlithwlwkewpdwqvpessevmlkilrkirar..stp

PVlIHCSGGIGVTGMLISIMIGIEQGLSTG-GVDVMAIVNKMRS-QRMNMIQTEEQYQFVHYVLLE
|| |||| |.| .| |... | ..   |     |.  || ..|   |   .|| .|| ..  |||.
pv.ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 696-937 1.9e-28 93.9 In-house 50-288 (310) alignment 
Range on Protein: 696-937
Range on HMM: 50-288/310.0
SENKKRNRFKTILPYDNNLLTLRPISSRgdcSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSItSDGGIVRCQQYWPdAIG
 .. ..||.  ..  |.  . |.   ||    . || | |.     .  || .|||| .|..||||.|.||    ||..  . .. |  .|  ||| ..|
kkymhknrysdvvcldtsrvklkidksr...yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckv.geegrpkcvgywp.slg

VAAFYGPFKIIVEGinDnKVSEERIIKLSMTSSS---SSDNS---HKTIHHYLFK--CWPDHGVPATptSTHSFYEQIKMWLDLpPPVLIHCSGGIGVTG
|.  ||  ..   .  .    |  | .|..|        |.     | .   | |   ||| |||      |.  ...   .    |...||| |.. ..
vtetygcirvtnls..e.sseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde..kchtvpqrllaqvrh.gpcvvhcsagkdrly

MLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLE
..... . |..      ||.  .. ... .|.  |||| || ....| . 
vvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 728-945 2.6e-28 93.7 In-house 75-284 (301) alignment 
Range on Protein: 728-945
Range on HMM: 75-284/301.0
HSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMmLSITSDGGIVRCQQYWPDAIGVAAFYGPFKIIVEgiNDNKVSEERIIKLSMTS
   | | .|.   . |.||||||||..|  ||| .. | |.  | | |. . .  . .|..| |  |.     | ||| ..  | ... ...|.| ..  
rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivm.lgqkvekleekceeylpvkisekldigrfkikik..nkelilnkkiskrtlev

SSS-SDNSHKTIHHYLFKCWPDHGVPATPTSThsfYEQIKMWLDLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEE
  |  . . .|. || .. |.|.||| . . .   .. ...  .   |...||| ||| .  .|.  .   . ..   ...   ....| .| | .||..
edstgkfatrtvthyqysewtdrgvPkshael...fdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtns

QyqfVHYVLLEAFYTIGKE
|   .... | . | . ||
q...lywmtlGtvyrlike
subfamily_PTPN13_pd Subfamily PTPN13 1006-1228 8.6e-28 92.4 In-house 47-266 (273) alignment 
Range on Protein: 1006-1228
Range on HMM: 47-266/273.0
LPPDEYRVVLNKKTEdFIHASYINGY--QEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDF-YRIKHHEMN
|| || || |....  .| ||.|.    ..  ..|..  |   |...|| |.   |..||.|.   .| .   | .||| . ...      ....  ...
lPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvq

IDNYYTQTILRVLDTQAGEEQTIILIQLplSNiVSDELSHTERVGILSAIQEIEKIQRktGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEI
  . ...  | | |...|| . .  ...   .   |    .. . .|  ..|. ..|.   . ||.||||  . |||.. .... .. .. ...... ||
kldgfvvralavkdsesgesrevahlnf..vk.wPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkei

LYNMRTCKPGLITTPVQYKMVYLLLM
. ..|  . |.. |  || .||  ..
vrklreqrqgvvqtkdqyifvykail
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1009-1234 9e-28 91.7 In-house 69-286 (290) alignment 
Range on Protein: 1009-1234
Range on HMM: 69-286/290.0
DEYRVVLNKK-TEDFIHASYINGYQEarSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKH-HEMNIDNY
|  ||.|.     |..|| |..| .    ||... ..| |. ..| |....| ..|||||...|     | ||.| .      |  . .    | . |. 
dktrvilkdGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdan

YTQTILRVLDTQAGEEQTIILIQlpLSNiVSDELSHTERVGILSAIQEIEKIqrktgNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNM
  . .| | | ..| |  .  ..  .     |       . .|  .. . |.     . |. ||||  . |.| |  . ...| .   ..... ..   .
iikktlsvrdkdsGkehklkhlk..iks.wpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvral

RTCKPGLITTPVQYKMVYLLLMRYVEEF
| .. . .   .|| ..  .|. .  .|
rnsrlnsvqvdiqylalveilldlGkdf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1009-1224 2.7e-27 90.5 In-house 16-232 (237) alignment 
Range on Protein: 1009-1224
Range on HMM: 16-232/237.0
DEYRVVLNKK--TEDFIHASYINGYQE-ARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATyDSERHFDFYRIKHHEM-NID
|  ||||.    . |.| |.|..|..   ...| |. | . .  .|| |. ..||||||||  ..| .   |..||| | |  . .  . .  .   .. 
dhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvltvslkkkeefs

NYYTQTILrvlDTQAGEEQTIILIQLPLSNIVSDELSHTERVGILSAIQEIEKIQRK-TGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEIL
.|  ...|    .. .. . . ||.        |     .   .|   ..| .  .. .   | ..|||  | |.|.| |. . ..| | .. |.||. .
dytvrsll...lskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyv

YNMRTCKPGLITTPVQYKMVY
|..   .| .| |  || ...
ysieedrpyiiqtkdqyvfih
PTPc_DSPc_SM00012 837-937 2.1e-26 87.5 In-house 1-105 (105) alignment 
Range on Protein: 837-937
Range on HMM: 1-105/105.0
TIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLDLP---PPVLIHCSGGIGVTGMLISIMIGIEQGLST-GGVDVMAIVNKMRSQRMNMIQTEEQYQFVH
|..|| .. ||||||| ...|  .. ...| .       .||..||| |.| ||... . | ..|  .. . ||.  ||...|.||..|.||||||.|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

YVLLE
 .|||
ralle
subfamily_PTPRN_pd Subfamily PTPRN 963-1231 3e-26 86.8 In-house 23-292 (297) alignment 
Range on Protein: 963-1231
Range on HMM: 23-292/297.0
DEILNMNRYEAHYKALQVLTVKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKT----EDFIHASYINGYQ-EARSFIVAESPTKLTAANFWSMIVK
| . | .| |....||     .|..        |.   ||   || |. || |....    .|.| || |   .  | ..| ...|   | |.|| |. .
dhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvwe

NKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMNIDNYYTQTI-LRVLDTQagEEQTIilIQLPLSNIVsDELSHTERVGILSAIQEIE
. . |||.|. . | .|  |..||| .  .  |.   ..    .  |.|  ... |. |.|.  | .|.   |.       .|   ..   .|   . ..
qGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqts..etrtv..tqfhflswp.eegvPasaksllefrrkvn

KIQRKtGNNPILVHCSDTVSRSGVFCVLYTSIQQM-KIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
|  |     ||.||||| . |.||....   .... |  ....|   |  .|  .|||. |  |.....  . . |
ksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
0049772 (Phosphotyrosine protein) phosphatases II 1003-1233 6.6e-26 87.2 In-house 53-282 (314) alignment 
Range on Protein: 1003-1233
Range on HMM: 53-282/314.0
DLYLPPDeYRVVLNK---KTEDFIHASYINGYqeaRSFIVAESPTKLTAANF----------WSMIV--KNKCSVIVM---------------------L
   || |  ||.|..   .. |.|.|||..|.   ..||... |.. |  .|          |.|..  .... .|||                     |
ldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpl

CDIVEMEvdtcyqywpaTYDSERHFDFYRikhHEMNIDNYYTQTILRVLDTQAGEEQTIILIQlplsnivsdelshtervgILSAIQEIEKIqrkTGNNP
... .             . .........    |.. ...........|..    ... .| .                  ...... ||.      ..|
lildgng..........neptaadlellk...eelydpelferlgikylripvpDgsaplled..................fdeflefieea...dkggp

ILVHCSDTVSRSGVFCVLYTSIQQMkieqQVNIYEILYNMRTCKP-----GLITTPVQYKMVYLLLMRYVEE
.||||.. ..|.|.|.|..  . ..    .|.. |.|  .| . |     |.| .. || ...  |. |.. 
vlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 696-861 3.1e-25 83.6 In-house 31-189 (297) alignment 
Range on Protein: 696-861
Range on HMM: 31-189/297.0
SENKKRNRFKTILPYDNNLLTLRpissRGDCSHSYINASYIDGYKKKH--QFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITsDGGIVRCQQYWPDA
.   ..||.. || .|.. . |.    |.   . |||| |.   ....  ..| .|||| .|. |||.|....|.  | |.  .  ..|  .|  |||..
nsslrknryrdilatddtrvkll....rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklq.edGrdkcapywpsv

IGVAAFYGpfKIIVEGINDNKVSEERIIKLSMTSSSSsdNSHKTIHHYLFKCWPDHGVPATPTSTHSF
 .     |  ...|| . .     .|.|   ..      . .. ..|  |  |||||||.       |
vqerlkag..dvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrf
0043147 (Phosphotyrosine protein) phosphatases II 1018-1224 3.5e-25 84.1 In-house 3-154 (172) alignment 
Range on Protein: 1018-1224
Range on HMM: 3-154/172.0
KTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIvemevdtcyqywpatydserhfdfyrikhhemnidnyytqtilrvldt
. .|.|.|||...|   ..||.   |.  | | || |. ......||.|..                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

qageeqtiI---------LIQLPLSnIVSDELSHtERVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIqqmkieQQVNIYEILYNMRT
                   ||.     . |         .|.... |.... .  ..|.|||||  |.|.|.....|  .      ......|..  .|.
........lydpellerlgiqylyl.pwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvre

CKPGLITTPVQYKMVY
..|| ...| ||. .|
kRpgavqnpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 1020-1231 5.8e-25 83.5 In-house 12-173 (176) alignment 
Range on Protein: 1020-1231
Range on HMM: 12-173/176.0
EDFIHASYINGYQearsFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERhfdfyrikhhemnidnyytqtilrvldtqa
 |.|.|..| |.     .|.   |.  | |.|. |. .......|.|.. ||..   |..|||  .. .                               
ldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

geeqtiiliqlPLSN-IVSDELSHTErVGILSAIQEIEKIQRKTgnNPILVHCSDTVSRSGVFCVLYtsiqQMKIEQQVNIYEILYNMRTCKP-GLITTP
              .  . |    .    .|.....|.. ...   .|.|||||  ..|.|.....|     .. |......|.|. .| ..| | ..||
...........qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

VQYKMVYLLLMRYV
 ||...|  .... 
eQyrflyefellll
0049260 (Phosphotyrosine protein) phosphatases II 1027-1224 2e-24 81.5 In-house 1-143 (152) alignment 
Range on Protein: 1027-1224
Range on HMM: 1-143/152.0
YINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWpatydserhfdfyrikhhemnidnyytqtilrvldtqageeqtii
.|.||   . || .. |.  |.|.|| |. ......||||.. .|.  . |.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

liqLPLSNIVSDELSHTERVGILSAIQEIEKIqRKTGNNPILVHCSDTVSRSGVFCVLYTSIqqmkieQQVNIYEILYNMRTCKPGLITTPVQYKMVY
     |   . |    .    .| ... |||. ..  ..|.|||||  |.|.|.....|  .      ..|...|..  .|...|| ...| |.. .|
...qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1020-1227 3.8e-24 79.9 In-house 76-275 (439) alignment 
Range on Protein: 1020-1227
Range on HMM: 76-275/439.0
EDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEmevdtCYQYWPATYDSErHFDFYRIKHHEMNIDNYYTQtILRVLDTQA
  .| | ||.|| . . .| .. |.| |. .|| .....|.. ||||...||      |.|||.  .   . |      ..... ||  .  ..|.. . 
shyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve.....sykywpsdaevc.ygdiavrvdrnielpnyvir.gfkvfnerd

GEEQTIILIQLPLSNIvSDELSHTERVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQ
  |.   ..|.       |.   ..   .|  .. |.  . |    |..||||  | |.|    |  ...|.|.|..|.|  |.  .|  .  .. . .|
ttekertvlqfhyiaw.pdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcq

YKMVYLLL
| ..|  .
yvfiynav
0044763 (Phosphotyrosine protein) phosphatases II 1009-1230 5.4e-24 80.2 In-house 3-170 (178) alignment 
Range on Protein: 1009-1230
Range on HMM: 3-170/178.0
DEYRVVLNKKT----EDFIHASYINGYqearsFIVAESPTkltaANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDserhfdfyrIKHHEMNID
|..||.|..       |.|.||.| ..     ....  |.    |... .. ......||.|.. .|.    |..|||  ..         |... ..|.
drtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.........iqylhipip

NYYTQTILRVLDTQAGEEQTIIliqlplsnivsdelshtervgilsaiqeiekiqrKTGNNPILVHCSDTVSRSGVFCVLYTSIQQmkieqQVNIYEILY
 . ....|. ..      ....                                  .. ..|.|||||  |.|||.....|  ...     .....|.. 
Dhgvpdllehflefvefieeal..................................dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

NMRTCKPgLITTPVQYKMVYLLLMRY
 .| ..|  ...| |.. .|.. .|.
lvrerRp.ivpnpgqlrqLyefelrl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1009-1231 2.1e-23 77.7 In-house 48-270 (285) alignment 
Range on Protein: 1009-1231
Range on HMM: 48-270/285.0
DEYRVVLNKKTEDFIHASYINGY-QEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMNIDnYY
.| ||||...  |.||||..    ..  ..| .. |   | ..|| || ..| . ..||| ..|  |. |  |.|       .|  | |   | . .   
eetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckee.ai

TQTILRVLDTQAGEEQTIILIQLPL--SNIVSDELSHTERVGILSAIQEIEKIQRKtgNNPILVHCSDTVSRSGVFC-VLYTSIQQMKiEQQVNIYEILY
. |||  |     |. .   . .         |.|.  .   ..   . ..|.. |  ..|| ||||  | |.  |  . |..|. |. . .... .|. 
agtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirime.npniemldivr

NMRTCKPGLITTPVQYKMVYLLLMRYV
.||. .   . . .|. ..|..|| |.
emramrfqavqshmqflflyvvlmeyf
0048076 (Phosphotyrosine protein) phosphatases II 819-936 2.8e-23 77.6 In-house 32-140 (145) alignment 
Range on Protein: 819-936
Range on HMM: 32-140/145.0
RIIKLsmtsSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLDLPPPVLIHCSGGIGVTGMLISIMIGIEqglstGGVDVMAIVNKMRSQR
... |    .|  ..  ... .||.  |||||||  .    .|.|.|. .|. . |||.||| |.| ||.|. ... ..      ||..  .....||||
tvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqr

MNMIQTEEQYQFVHYVLL
........|..|.....|
pgavpnpgqlrflyefel
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1009-1226 5.4e-23 76.4 In-house 21-236 (239) alignment 
Range on Protein: 1009-1226
Range on HMM: 21-236/239.0
DEYRVVLNKK----TEDFIHASYINGYQE-ARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPatyDSERHFDFYRIKHHEMNI
|  ||||.|       |.| |||.  |.   ...| ..   . .. .|| |. ...  |||||  ..|     |.||||   ||  ..   |.  .. ..
dhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskycnlrvtlrktev

DNYYtqtILR-VLDTQAGEEQTIILIQLPLSnIVSDELSHTERVGILSAIQEIEKiQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEI
   |   |.| .. .| |. .   . |  .. .  |.        .|   ..| | .   |  | ..|||  | |.| | |. . ..| | .. |.|.. 
fady...iirtfvmsqvgqteeryvyqyhft.vwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifny

LYNMRTCKPGLITTPVQYKMVYLL
.  .|  .| .. |  || ...| 
vkairedrphmvqtseqyvfihla
subfamily_egg_pd Subfamily egg 692-939 5.5e-23 76.1 In-house 34-270 (307) alignment 
Range on Protein: 692-939
Range on HMM: 34-270/307.0
VANCSENKKRNRFKTILPYDNNLLTLrpISSRGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITSDggiVRCQQYWP
 |  ..|... | | .   |   ..|     ||  .  .| | ...|     .|| .| ||  |  ||||...||..  |.|. |        ||. |||
taasdnnlekarskrvhckdssrvkl..elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes...erceyywp

DAIGVAAFY--GPFKIIVEGINDNKVSEERIIKLSMtssSSSDNSHKTIHHYLFKcWpdhgvpATPTSTHSFYEQIKMWLDLPPPVLIHCSGGIGVTGML
 |   .. .  | ..|   .....     |. || .     .|.  . . |.    .         .  .| .. ...  .|  ||....  |.  .. |
kaesdslvtvpGslrienlkvdskadplfrvtklkl...vGgddeerflehwqgd.v......nnssdvysplrvlrklrnlskpvvvqdilGvskaatl

ISIMIGIEQGL--STGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
..| | . . |   .    |.  |  .| .|   ...  .| ||. ..|  |
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1009-1227 5.6e-23 76.3 In-house 20-236 (239) alignment 
Range on Protein: 1009-1227
Range on HMM: 20-236/239.0
DEYRVVLNKK----TEDFIHASYINGYQE-ARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPatyDSERHFDFYRIKHHEMNI
|  ||||.|       |.| |||.  |.   ...| ..   . .. .|| |. ...  |||||  ..|     |.||||   ||  ..   |.  .. ..
dhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskycnlrvtlrktev

DNYYtqtILR-VLDTQAGEEQTIILIQLPLSnIVSDELSHTERVGILSAIQEIEKiQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEI
   |   |.| .. .| |. .   . |  .. .  |.        .|   ..| | .   |  | ..|||  | |.| | |. . ..| | .. |.|.. 
fady...iirtfvmsqvgqteeryvyqyhft.vwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifny

LYNMRTCKPGLITTPVQYKMVYLLL
.  .|  .| .. |  || ...| .
vkairedrphmvqtseqyvfihlav
0051082 (Phosphotyrosine protein) phosphatases II 1020-1226 5.8e-23 76.6 In-house 3-148 (151) alignment 
Range on Protein: 1020-1226
Range on HMM: 3-148/151.0
EDFIHASYINGYqearsFIVAESPTKltaaNFWSMIVKNKCSVIVMLCDIVEMEvdTCYQYWPATYdserhfdfyrIKHHEMNIDNYYTQTilrvldtqa
.|.|..||. |.     ...   |.      |. .. ......||.|.. .|..  .|..|.|..           |... . |..  ...         
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..........ievlhipildwpdpg.........

geeqtiiliqlplsnivsdelshteRVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQmkieqqVNIYEILYNMRTCKPGLITTPVQ
                            .. |..|. .. ....|.|.|||||  ..|.|....||  ...      |...|.|  .| . ||..... |
.........................lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

YKMVYLL
. .... 
flfqlfa
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1012-1234 2.3e-22 74.4 In-house 57-280 (307) alignment 
Range on Protein: 1012-1234
Range on HMM: 57-280/307.0
RVVLN--KKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERhfdFYRIKHHEMNIDNYYTQ
|.|..    . |.||| |.    . . ||.|. | . |  .||.|....|   ..|||...|.    | ||||.    .     .  . . ....|  ..
rivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl...vfgeapntisvanlgak

TILRvlDTQAGEEQTIILIQ---------LPLSNIVSDELSHTErvgiLSAIQEIEKIQRKTgnNPILVHCSDTVSRSGVFC-VLYTSIQQMKIEQQVNI
..    | .  .  |. .           |  .|       ...    |.||  .| .. .|  ||..||||  | |||    . .   . .. .   ..
klap..dedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin....ltainlleavrydt..npvvvhcsaGvGrsGtivaislvqdkmiaGinckdm

YEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEF
 ... ..|. ..  | | .||  .. .|. |  | 
kklveelrsqrhyaiqteaqylylhrvlleyflel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1009-1233 3.6e-22 73.5 In-house 61-289 (305) alignment 
Range on Protein: 1009-1233
Range on HMM: 61-289/305.0
DEYRVVLNK-KTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDfyrIKHHEMNIDNYY
|. || |.     ..||| |.    ... || ...| . | |.|| | ...|   | |||...|     |..|...  . . .|.    | . . .    
dnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe...ekgqkisvkfes

TQTILRVLDTQAGEEQTIILIQLPLSNIVSDELSHTE---RVGILSAIQEIEKIQR--KTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNI-YE
..|.  . |..|  ..|...|. | ..       |       |. .| . | ..    ..   || ||||  . |.|   .|   ..|.   |...    
svtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdk

ILYNMRTCKPGLITTPVQYKMVYLLLMRYVEE
||  .|  .   | |  || .|. ... |...
ilqkireqrnnsiqtdaqylfvhqvilnyfrk
0048179 (Phosphotyrosine protein) phosphatases II 827-933 7.3e-22 73.1 In-house 38-139 (144) alignment 
Range on Protein: 827-933
Range on HMM: 38-139/144.0
SSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLDLPPPVLIHCSGGIGVTGMLISIMIGIeqglsTGGVDVMAIVNKMRSQRMNMIQTEE
..   .   .....||.  |||||||  ..   .|.| |. .|. . |||.|||.|.| ||.|. . . .     . |...  ... .||.|........
eeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpg

QYQFVHY
|..|...
qlrfLle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1009-1230 5e-21 70.0 In-house 56-270 (288) alignment 
Range on Protein: 1009-1230
Range on HMM: 56-270/288.0
DEYRVVLNKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDF--YRIKHHEMNIDNY
|  || |.  .. .|.|  .   .  | .| |..| . |  ..| |....    |||||...|   .   .|.|     . ..      .|..  .||  
ditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidkl

YTQTILRVldTQAGEEQTiILIQLPLSNIVSDELSHTervgILSAIQEIEKIqrKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNM
 . ..||.  .. |||.  |. .| | .   | . .      || .. .| .  |. ..||.||.|  | |.| . .    ....... .. | ..| ..
vkvsllri..skegeekv.ivkilhlleWdddgvPen....ylsplrllevl..kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllakl

RTCKPGLITTPVQYKMVYLLLMRY
|  .   |.|  ||  |. ... .
reerfkaiqtemqylyvhrcvlee
subfamily_CG42327_pd Subfamily CG42327 696-861 7.4e-21 69.1 In-house 26-186 (319) alignment 
Range on Protein: 696-861
Range on HMM: 26-186/319.0
SENKKRNRFKTILPYDNNLLTLRPISSrgDCSHSYINASYIDGYKKKH-QFIATQGPLPQTLVDFWRLIWQEDICCILMMLSiTSDGGIVRCQQYWPDAI
   |...|.  ..|  .   .|. |..  | .  |..|||. ||.. . ..||.| .| ..  ||||..|.     |. . .  |. || .| .|.|   
vtskdksrvinvvPlPetrvvlqrigd..ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd.lselGikvcaeylPtke

GVA--AFYGPFKIIVEGindNKVSEERIIKLSMTSsSSSDNSHKTIHHYLFkCWPDHGVPATPTSTHSF
.      || ... . |   ..| .. .|   .      ..  . . || .  |.. .||| ...  . 
tldntslyGdilvtlkg...revkdryaistlllk.rvdkeesrelthywy.kwleaevPaeeaaliam
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 691-943 9.8e-21 68.7 In-house 36-280 (312) alignment 
Range on Protein: 691-943
Range on HMM: 36-280/312.0
EVANCSENKKRNRFKTILPYDNNLLTLrpissRGDCsHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITSDGGiVRCQQYW
|..     |  ||.  |  .|   .||      ||    || | ..    |  .|..||||| .| . ||.|      ..|... ..  ||   .| .| 
ectaflkfkdlnrypniqcwdrgrftl.....agde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgs.ekcakyi

PDAIGVAAFYGpFKIIVEGIND---NKVSEERIIKLSMTSSSSSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMwlDlPPPVLIHCSGGIGVTG
 | .|   .    ..  |   .      | ..| .  .     .      . || .  |||||.| .  ... .   .|   |   ||. ||| |.| ||
sdivgfvdled.hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk..d.kkpviahcsagvgrtg

MLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFYTIG
 |. |   |         .|  .   .| .|   ...  || ..  ..|| .|. |
tlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1014-1229 4.4e-20 66.5 In-house 60-267 (281) alignment 
Range on Protein: 1014-1229
Range on HMM: 60-267/281.0
VLNKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMNIDNYYTQTILR
. ||.. |.||| ||      | .|... | | | |.|| || ... . |||||...| . . | .|.|       .|| . ... .  ...    | | 
mpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrln

VldTQAGEEQtiiLIQLPLSNIVSDE-LSHTERVgILSAiqeIEKIQRKtgNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQV-NIYEILYNMR-TCK
.  .  || .   ||   | .   |  . ..  | .|     . ||. .    | ..|||  | ||| .  .  ..| ..    . .| .|.  .| | .
l..syegetr...lithwlwkewpdwqvpessev.mlki...lrkirar..stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgr

PGLITTPVQYKMVYLLLMR
   . |  || ... .|. 
aasvqtlqqymliwkvlld
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 736-932 7.2e-20 65.6 In-house 83-281 (302) alignment 
Range on Protein: 736-932
Range on HMM: 83-281/302.0
IDGYKKKHQFI-ATQGPLPQTLVDFWRLIWQEDICCILMMLSITsDGGIVRCQQYWPDAIGVAAFYGPFKIIVEGINDNK--VS---EERIIKLSMTSSS
.|| .||..       |  .||  .| || | ... .  . |.  ...  .| .|. | .|    .| . .    ....    .   . .. .. .. . 
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfv.edeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknek

SSDNSHKTIHHYLFKCWPDHGVPATPtstHSFYEQIKMWLDLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQ
  .. .||..  .| .||||| |. .   ..  . .|        ||.||| |.| || |..|  ||.  .     |.. ||  .|. |   .|.|.|  
kkkkvkktvdilafsawpdhGapkea...ytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

FVH
.. 
yll
subfamily_egg_pd Subfamily egg 1019-1230 1.1e-19 65.2 In-house 67-269 (307) alignment 
Range on Protein: 1019-1230
Range on HMM: 67-269/307.0
TEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMevDTCYQYWPATYDSERHF--DFYRIKHHEM--NIDNYYTQTILRV
..||||| ...|      ||.|..| | |  .|| |. ....  ||||   .|   . |  ||| . .    .    .||.  ..  . |  .. | |..
lddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl

LDTQaGEEQTIILIQLPLSNiVSDelshtervgILSAIQeIEKIQRKTgNNPILVHCSDTVSRSGVFCVLYTSIQQMKIE--QQVNIYEILYNMRTCKPG
. ..  ||. .   |  . | .||         . | .. . .  |.   .|..|.. . ||.....  . ... ..      .  . .    .|  .. 
vGgd.deerflehwqgdvnn.ssd.........vysplr.vlrklrnl.skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrl

LITTPVQYKMVYLLLMRY
 . ....| .|| |.. .
svesvllylfvyrlvlff
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1020-1219 1.1e-19 65.3 In-house 75-269 (301) alignment 
Range on Protein: 1020-1219
Range on HMM: 75-269/301.0
EDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMN--IDNYYTQTILRVLDT
   ||| .|.   ... ||.. .| | |. .|| |.|  .   ||||.  || ... | .| | .  .. . . ..|| ....  ...  ..  |.| |.
rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleveds

QA-GEEQTIILIQlpLSNIVSDEL--SHTERVGILSAIqeiekiqrKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLI
    . .|..  |   |.    ..  ||.|   ..  .        |  ..||.||||. . ||  |       .... ...... | | ..|  .   .
tgkfatrtvthyq..ysewtdrgvPkshaelfdlmelv........kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngv

TTPVQ
 |  |
qtnsq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1019-1236 1.5e-19 65.3 In-house 45-265 (290) alignment 
Range on Protein: 1019-1236
Range on HMM: 45-265/290.0
TEDFIHASYINgYQEARSFIVAESPTKL-------TAANFWSMIVKNKCSVIVMLCDIVEMEVD----TCYQYWPATYDSERHFDFYRIKHHEMNIDNYY
..|.|||...  . .   .|. .|| .        |  .|| |. . |   .||||.  | . .    .| .| | . . |  |.   .|  ..  ..  
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

TQtilRVLDTQAGEEQTIILIQLPLSNIVSDElSHTERVGILSAIQEIEkiqrkTGNNPILVHCSDTVSRSGVFCVLYTSIQQMK-IEQQVNIYEILYNM
 .   | |  . ..|.   .    |..  . .    .   .||.|| ..     . . |..||| | .||| ..  .  . | .   ...|.. ..|...
et...RelvvkfddeeeftvtHsllkgWnkln.vqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkal

RTCKPGLITTPVQYKMV-YLLLMRYVEEFEA
|  .  .||.. ..  | . .... .|. ..
rkqralaitsalelafvdagivllaievldq
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 996-1225 1.9e-19 64.4 In-house 45-230 (392) alignment 
Range on Protein: 996-1225
Range on HMM: 45-230/392.0
NLPLVRSDLYLPPDEYRVVL----NKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEvdtcyqywpatydserhf
||.  | .  || |. ||.|    .   .|.. ||||....  ...| ...|   .  .||.|. ... . |.|. .. | .                  
nlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..................

dfyrikhhemnidnyytqtilrvldtqAGEEQTIiLIQLPLSNIVSDE-LSHTErvGILSAIQEIeKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQ
                            |...     |  ...   ..   ||    .|  |.|. |..      |...|||  | |.||   . . . .
...........................kgddart.vaqfhftewPdkdvpkhts..sllkfikev.kadfGqythpliihcsagvgrtgvvisidsvvah

MKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYL
 |  . |...... |.|  .| .. |  || ..| 
akktrmvdvfnfvtnirrkrpymvqtkeqyafiyg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 728-945 3.2e-19 64.2 In-house 46-265 (290) alignment 
Range on Protein: 728-945
Range on HMM: 46-265/290.0
HSYINASYIDgYKKKHQFIATQGPLPQT-------LVDFWRLIWQEDICCILMMLSITSDG---GIVRCQQYWPDAIGVAAFYGPFKIIVEGINDNKVSE
  || |...  . .  ..|.|| |. ..       . .|| .. || .  . |.   .      . . |..| |...|    .. ...       ..  |
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

ERIIKLSMtssssSDNSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKmwlDLPPPVLIHCSGGIGVTGMLISIMIGIEQGL-STGGVDVMAIVNKMRS
.| . .        |. . |. |.|.| | .  |. .. .  |  ...|       ||..||  ||    .| .| .|      ..| | . ......|.
tRelvvkf.....ddeeeftvtHsllkgWnklnvqedtktllsliqkvk...asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

QRMNMIQTEEQYQFVHYVLLEAFYTIGKE
|| ..|...... || ....  .  ....
qralaitsalelafvdagivllaievldq
PTPc_DSPc_SM00012 1146-1228 7.7e-19 63.2 In-house 20-104 (105) alignment 
Range on Protein: 1146-1228
Range on HMM: 20-104/105.0
VGILSAIQEIEKIQRKTG-NNPILVHCSDTVSRSGVFCVLYTSIQQMKIE-QQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLM
  ||.......| ..| . ..|..||||. |.|.|.|..|.. .||.. | ..|.|..|.  .|. .||...|  || ..|  |.
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyrall
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 740-933 1.2e-18 62.0 In-house 2-198 (199) alignment 
Range on Protein: 740-933
Range on HMM: 2-198/199.0
KKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITsDGGIVRCQQYWPDAIGVAAFYGPFKIIVEGINDNkvSEERIIKLSMTSSSSSDNSHKTIH
| ....|||| || .|. |||...|.     |.|.         .    ||| .   .. || . . .. |  .  ..  |  | .|.....  | . | 
kgqrryiatqhplretmadfwqmvwetgsghivmvnddq.knkeadypfywpttesgtgkygslsvttktittk..pdytitaliltnnttappstreis

HYLFKCWPDHGVPATPTST----HSFYEQIKMWLDLPPPVLIHCSGGIGVTGMLISIMIGIEQ--GLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHY
|| |  | ..  |           |     |   .   ||..||| | | ||..... ||.       |  ||.. . ...|  |  .| . ..|.|.. 
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 742-933 2e-18 61.3 In-house 3-197 (198) alignment 
Range on Protein: 742-933
Range on HMM: 3-197/198.0
KHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITsDGGIVRCQQYWPDAIGVAAFYGPFKIIVEGINDNkvSEERIIKLSMTSSSSSDNSHKTIHHY
....|||| || .|| |||...|.     |.|.         .    ||| .   .. || . . .. |  .  ..  |  | .|.....  | . | ||
qrryiatqhplretladfwqmvwetgsghivmvnddq.knkeadypfywpttesgtgkygslsvttktittk..pdytitaliltnnttappstreishy

LFKCWPDHGVPATPTST----HSFYEQIKMWLDLPPPVLIHCSGGIGVTGMLISIMIGIEQ--GLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHY
 |  | ..  |           |     |   .   ||..||| | | ||..... ||.       |  ||.. . ...|  |  .| . ..|.|.. 
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 973-1232 3.9e-18 59.9 In-house 30-286 (302) alignment 
Range on Protein: 973-1232
Range on HMM: 30-286/302.0
AHYKALQVLTVKPNSvLRNFgLSNLPLVRSDLYLPPDEYRVVLNKKTEDFIHASYINGYQEARSFIVAESPTKLTA---ANFWSMIVKNKCSVIVMLCDI
. .|... . |. ..  . |  .||   .|. .  .|. .| |... .....|| ..  .  || |.|  |.. ..   ..|| |. ..|.  .|.|   
kefkkidtmkvdlek.Ckaf.kknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvge

VEMEVdTCYQYWPATYDSERHFDFYRIKHH--EMNIDNYyTQTILRVLDTQAGEEqTIILIQLpLSNIVSDELShtERVGilSAIQEIEKI--QRKTGNN
 |..  |  ...| . ..  ...  ..     |   ..  |. .. ||     .   .. ... |.|  ...    ....  ..|....|.  .   ...
eelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsns.vlanvyv.ltnWkqkkvp..vkya..eliktaakvfakkikade

PILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYVE
....     . | |.| .| ....... ....|| ||. ..|. .|  . .  || ..|. |. |. 
ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 693-792 3.3e-17 57.2 In-house 42-152 (350) alignment 
Range on Protein: 693-792
Range on HMM: 42-152/350.0
ANCSENKKRNRFKTILPYDNNLLTLR--PISSRG---DCSH-SYINASYIDGY----KKKHQ--FIATQGPLPQTLVDFWRLIWQEDICCILMMlSITSD
..  |   .||.| ||||. .   |.  . || .    .|   ||||.|.       . . .  .||||.|||.|. ||...| . ..  ||.. .   .
seGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl.tsdve

GGIVRCQQYWPD
 .. .|..||..
lnlekcyrYWqe
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1017-1230 5.3e-17 56.3 In-house 76-289 (310) alignment 
Range on Protein: 1017-1230
Range on HMM: 76-289/310.0
KKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSErHFDFYRIKHHEMNIDNYYT--QTILRV
 . ||.||| |..      .||... | . |  .|| || ....  |..|| ..|     |  |||.   .|  .   |.       ...     ..  |
sryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte.tygcirvtnlsesseefeicnlavtfv

LDTQAGEEQTIILIQLPLSNIVSDELSHTErVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLI
 |    .||   | .| .| |   .   .  |         ...  .    | .||||  . | .| . |  .|....  ..|.. |.  ...  .   |
pdnvpvdeqpanlkelrvslikwpnwpdrg.vpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraici

TTPVQYKMVYLLLMRY
 |..|| ..  . . .
qtelqyliidrvriif
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1017-1233 2.8e-16 54.0 In-house 76-291 (305) alignment 
Range on Protein: 1017-1233
Range on HMM: 76-291/305.0
K-KTEDFIHASYINGY-QEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIK-----HHEMNIDNYYTQ
|    |.||| |.       . ||.|. |   |  .|| |...||   |||||  ||.    | |||||.    ...    .       . |. |.    
kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqi

TILRVldtQAGEEQTIILIQLPLSNIVSDELSHTErvgiLSAIQEIEKIqrKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQ-VNIYEILYNMRT
|.|..       .|.. . .|  ..     .        |.... .  |  .  . ||.||||  . |.|    .   ....  ...   . |..  .| 
tllnl...tysgdqkmsvrhlqwtewpdrgvppck....ltslellsai..rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrd

CKPGLITTPVQYKMVYLLLMRYVEE
 .   | . ||| ... ... |. |
qrafsiqndvqylfihrvmlnyfle
subfamily_CG42327_pd Subfamily CG42327 1016-1126 1.5e-15 51.7 In-house 52-167 (319) alignment 
Range on Protein: 1016-1126
Range on HMM: 52-167/319.0
NKKTEDFIHASYINGYQEAR-SFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPA--TYDSERHFDFYRIK-HHEMNIDNYYTQTI
... . ...|||. ||..|. |.| |. . . ....|| .. ...  ||| |.|. |  .. | .|.|.  | |... .  ...   .    |.|.. |.
dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistl

-LRVLDTQAGEEQTII
 |. .| .   | |  
llkrvdkeesrelthy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 833-940 1.7e-15 51.3 In-house 86-195 (440) alignment 
Range on Protein: 833-940
Range on HMM: 86-195/440.0
NSHKTIHHYLFKCWPDHGVPATPTSTHSFYEQIKMWLD--LPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQF
   .|...| .. |||.|||        . ....   .     |.|.||| | | ||..|..   . .   .  .|.....| ||..| .|.|| ||| |
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

VHYVLLEAFY
|| ..||.. 
vheavlegll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1044-1231 3.6e-15 50.7 In-house 37-221 (255) alignment 
Range on Protein: 1044-1231
Range on HMM: 37-221/255.0
TKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEmNIDNYYTQTIlrVLDTQAG-EEQTIILIQLPLSNIVSDELSH
  || ..|. .||..| .|.|||||  | .|. | .|.|   |  . .    .   . .. .   .|.  .. .. |   .|  .        .     .
ysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtl..eitstlgekkkthtvkhysykGWieknaPe

TERvgilsAIQEIEKIQRKTgnNPILVHCSDTVSRSGVFCVLYTSIQ----QMKIEQQVN--IYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
  |      |..| |. |..   ...||||  . ||  | .     |    ...  . |.    ..| ..|  ... | ||.|  .  |... .|
lar.....eilnilkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 675-936 1.3e-14 48.4 In-house 29-282 (302) alignment 
Range on Protein: 675-936
Range on HMM: 29-282/302.0
KSEFQRLQNFghlfSTEVANC---SENKKRNRFKTILPYDNNLLTLrpissrGDCSHSYINASYIDGYKKKHQFIATQGPLPQTL---VDFWRLIWQEDI
|.||......     ... .|    .| |.|. . .  .|.||. |      . .  ||.||| ..  . ... | .| |  ..     .|||...|| |
kkefkkidtm....kvdlekCkafkknlkknqsedvpildsnlvkl......eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

CCILMMLSiTSDGGIvRCQQYWPDAIGVAAFYGPFKIIVEGINdnKVSEER-IIKLSMTSSSSSDNSHKTIhhYLFKCWPDHGVPATPTSTHSFYEQI-K
  . ...  . .      ....|   |    || . . .  ..  |..||.    . .     |.    ..  |... |... ||   ...    ... .
vsvvilvg.eeelkk.tlselfpkksgdykeygkmfvNnrkVe..kaeeektryviEvlPegcsnsvlanv..yvltnWkqkkvpvkyaeliktaakvfa

MWLDLPPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLL
   .   ...|    |.|  |.... .. .|.  .   . .  ||...|||| ..... .|| ... .||
kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_ptpA1_pd Subfamily ptpA1 1014-1186 1.4e-14 48.7 In-house 69-251 (418) alignment 
Range on Protein: 1014-1186
Range on HMM: 69-251/418.0
VLNKKTEDFIHASYINGYQeARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSER---------HFDFYRIKHHEMNID
. .|.  |.| | ||.|    . ||... |   | |.|| |. .|.| .||||    |     | .|||     |.          |  | ..  |.  |
iqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqd

NYyTQTILR-VLDTQAGEEQTIILIQL---PLSNIVSDELSHTERVGILSAIQeIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYT
    . | | .  |  || . |   |    |  ||        . .  ..  |  . |     | ||.||||  | |.| ||    
pe.reiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq.nqiipssdrnvpiivhcsagvgrtgtfctavi
0048076 (Phosphotyrosine protein) phosphatases II 1103-1230 1.7e-14 49.2 In-house 25-142 (145) alignment 
Range on Protein: 1103-1230
Range on HMM: 25-142/145.0
IDNYYTQTILRVLDTQAGEEQTII-LIQLPLSnivsDELSHTERVGILSAIQEIEKIQRKtgNNPILVHCSDTVSRSGVFCVLYTSIQqmkieQQVNIYE
. ..   |.|.. ... ..|...| ...||.     |    .    .|.... ||.....  ..|.|||||  |.|.|.....|  ..     ..|...|
lkdlgittvlnltselellerlgiqylylpwp....Dhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll.....lgvslee

ILYNMRTCKPGLITTPVQYKMVYLLLMRY
.|  .|.. || ...| |....|......
alelvrsqrpgavpnpgqlrflyefelel
subfamily_hpo-7_pd Subfamily hpo-7 1047-1244 5.6e-14 46.7 In-house 46-240 (263) alignment 
Range on Protein: 1047-1244
Range on HMM: 46-240/263.0
TAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMNIDNY-YTQTILRVLDTqAGEEQTIILIqlplsniVSDELSHTER
| ..|...||..| .|.|||||  | .|. | .|.|   |  . .    .   ..  |    |. .| .|.    . .|.                ... 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.Kkkthtvkhy.......sykgWieknd

VGILSAIQEIEKIQRKTgnNPILVHCSDTVSRSGVFCVLYTSIQ----QMKIEQQVNI--YEILYNMRTCKPGLITTPVQYKMVYLLLMRYVEEFEAYGN
.     | .| |. |.    .. ||||  . ||  | |  .  |    ...  . |..   ..| ..|  ... | ||.|  .  |... .| .  | |.
pelareilnilkvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakge

FEGQK
 | . 
leaky
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1017-1106 6.2e-14 46.5 In-house 80-175 (350) alignment 
Range on Protein: 1017-1106
Range on HMM: 80-175/350.0
KKTEDFIHASYINGY----QEARSF--IVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMNIDNY
 .|.|.| |.|..      .   .|  | . .|.. |  .|. .|..||  ||..| . ||.... ||.||.    .. .  .   ..  |.|.. 
lstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimginds
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 697-939 7.5e-14 46.0 In-house 46-279 (303) alignment 
Range on Protein: 697-939
Range on HMM: 46-279/303.0
ENKKRNRFKTILPYDNNLLTLrpissrgdCSHSYINASYIDGYKKKhQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSiTSDGGIVRCQQYWPDAIGV
.| ..|||  ..  |   . |        .  ||| |||..   .| . | || ||..|  |||..| .. . |.|..|.  |.   .  .  .|     
knmdknrfvdvicldhskvkl........sdssyihasyleldssk.kailtqlplshtaadfwqmiieqkvkcvllllt.dseydklggdsvfprnqdf

AAFYGPFkIIVEGINDNKVSEERIIKLsMTSSSSSDNSHKTIHHYlfKCWPDHGVPAT--PTSTHSFY---EQIKMWLDLPPPVLIHCSGgIGVTGMLIS
  |   . | |  ..  ....   .|. .. |  . .|   .|||  | ||   .|.   |   .  .     .. . |  |.| .  ||  | .| .  
lkfeers.irvgefkrvelgdgwvlkv.lsvsngdyksflhvhhy..kawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsg.cgragtfal

I-MIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
.    .        .|..  ....|  |.  .|   |. .|. .| |  
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 747-944 8.8e-14 46.2 In-house 39-226 (255) alignment 
Range on Protein: 747-944
Range on HMM: 39-226/255.0
AtqgplpqTLVDFWRLIWQEDICCILMmLSITSDGGIVRCQQYWPDAIGVAAFYGPFKIIVEGindnKVSEERIIKLSMTSSSSSDNSHKTIHHYLFKCW
        |.  |.. | | .   . | |.   . |...|..|.|        .   ....       ...  .  | .||  .     .|..|| .| |
l.......tvdkfyqtivqtktevvvm.lcdfaeegvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhysykGW

PDHGVPATPTSTHSFYeqiKMWLDLpPPVLIHCSGGIGVTG------MLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAFY
...  |  .      .   |.  |   .|..||| ||| .       ..   ||   .  .|...| . .....||.|   |.|  |  |  ...|. ..
ieknaPelareilnil...kvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvf

TIGK
  |.
pkge
0048179 (Phosphotyrosine protein) phosphatases II 1138-1225 1.3e-13 46.3 In-house 59-139 (144) alignment 
Range on Protein: 1138-1225
Range on HMM: 59-139/144.0
DELSHTERVGILSAIQEIEKIQRktGNNPILVHCSDTVSRSGVFCVLYtsiqQMKiEQQVNIYEILYNMRTCKPGLITTPVQYKMVYL
|    .    .|.... ||....   ..|.|||||  |.|.|.....|     || .......|.|. .|.. || ...| |......
Dhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmk.klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1034-1224 1.6e-13 45.3 In-house 4-197 (199) alignment 
Range on Protein: 1034-1224
Range on HMM: 4-197/199.0
ARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEM-EVDTCYqYWPATYDSERHFDFYRIKHHEMNIDNYYTQTILRVLDTQAGEEQTIILIQLPL
 | .|... | . | |.|| |. .     |||. |     |.|  . |||.|  .  ..    .  . .     || | | . .  .    |  . .  .
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

SNIVS-DELSHTERVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIE--QQVNIYEILYNMRTCKPGLITTPVQYKMVY
.          .  ||.. | .|. |   .  . |..|||||    .|||  |   ..  .      |...|.   .| .. |.|..  .|...|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1034-1224 1.8e-13 45.2 In-house 3-196 (198) alignment 
Range on Protein: 1034-1224
Range on HMM: 3-196/198.0
ARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEM-EVDTCYqYWPATYDSERHFDFYRIKHHEMNIDNYYTQTILRVLDTQAGEEQTIILIQLPL
 | .|... | . | |.|| |. .     |||. |     |.|  . |||.|  .  ..    .  . .     || | | . .  .    |  . .  .
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

SNIVS-DELSHTERVGILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIE--QQVNIYEILYNMRTCKPGLITTPVQYKMVY
.          .  ||.. | .|. |   .  . |..|||||    .|||  |   ..  .      |...|.   .| .. |.|..  .|...|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
I-set Immunoglobulin I-set domain 534-615 4.9e-13 40.7 Pfam-A 3-86 (90) alignment 
Range on Protein: 534-615
Range on HMM: 3-86/90.0
LLSTTKDINAAKGDDIVLKLCVGGEPRPDVTWFFNNQIIGDDEHYEMSEED--NTLLIHDILPMHAGVYNYTASNLLKSISGQI
.  . ||... .|... |.  | ||| |.|.|. ... .  ........|.   || |... .  .| |. .|.| ... . ..
ftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeaka
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1009-1108 4.9e-13 43.6 In-house 46-149 (297) alignment 
Range on Protein: 1009-1108
Range on HMM: 46-149/297.0
DEYRVVLNK--KTEDFIHASYINGYQEAR--SFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMNID
|. || | .    .|.| | |.   .|     .|.|. |.. |  .|| .....   ||||.. . |   | |. ||| . .  ..   . ...     |
ddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsd

NYYT
.. .
efdr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1148-1225 8.1e-13 42.5 In-house 111-188 (440) alignment 
Range on Protein: 1148-1225
Range on HMM: 111-188/440.0
ILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYL
.|  ||.... | |.|| |.|||||  ..|.||  .. . ... |  .|..|. .. .||  .| .. || || .|. 
vlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhe
fn3 Fibronectin type III domain 399-477 1.5e-12 40.7 Pfam-A 5-85 (85) alignment 
Range on Protein: 399-477
Range on HMM: 5-85/85.0
NLTASV-GLITAQLSWNEPNSTNGIINNYIILISTSSSSS-SSVRNLSTGNKIIDIKELLPNMGYTFSVAAVNEGGIGQRS
||..|  .  ...|||..|.. .| | .| .  ....... .  ....   .   ...| |.. |.|.|.|||..| |..|
nlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 695-851 2.1e-12 41.2 In-house 93-235 (244) alignment 
Range on Protein: 695-851
Range on HMM: 93-235/244.0
CSENKKRNRFKTILPYDNNLLTLrpisSRGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMlsitsdGGIVRCQQYWPDAI
  .|  .||  . ||.| | . |    |.|  . .|||||..    .  ..| || || .| .|||... .  .  ....      | .   ..||||. 
npnnswknregaglpfdfnrvpl....skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvl......gsveeedeywpdse

GVAAFYGpfKIIVEgINDNkvSEERIIKLSM-TSSSSSDNSHKTIHHYLFKCWPDHGV
 .  .     | |  . |    | . || |     |  ..||...  .    ||  | 
plewyee..ditvt.ltdr..defknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 737-812 9.3e-12 39.0 In-house 230-300 (440) alignment 
Range on Protein: 737-812
Range on HMM: 230-300/440.0
DGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITsDGgivRCQQYWPDAIGVAAfYGPFKIIVEGIND
.|| ||  ||||| ||  |..|||||. .  |  |.|.  .  |     |  |||      . .||| .   | ..
egyskknafiatqmpldstvldfwrlvhdyristiimlnqln.dk...tcsiywpvntrsvt.fgpftvghkgsen
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1041-1228 3.5e-11 37.1 In-house 97-283 (302) alignment 
Range on Protein: 1041-1228
Range on HMM: 97-283/302.0
ESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEM--NIDNYYTQTILRVLDTQAGEEQTIILIQLPLSNIV-S
  | | |   .|..| . . ...| ||..|| |   | .|.    . | .|  | .|  ..  .....  .  ...   .  .|..    . ... .. |
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

DELSHTERVGILSAIQEIeKIQrKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQykMVYLLLM
    |       .|.. . |   ..  . .|||||  | |.| .  .   ||  . ..  .. .|.  .|.|. | . .  |  ..||||.
awpdhGapkeaytaldil.kfc.esykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq..liylllc
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 876-939 5.1e-11 36.8 In-house 2-65 (69) alignment 
Range on Protein: 876-939
Range on HMM: 2-65/69.0
LIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
..||| | | || .|.||. . .  |   ||..  |. ||  |  |.  | .| |.|  | ||.
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 877-939 5.7e-11 36.6 In-house 2-64 (69) alignment 
Range on Protein: 877-939
Range on HMM: 2-64/69.0
IHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLLEAF
.||| | | || .|.||. . .  |   ||..  |. ||  |  |.  |..| |.|  | ||.
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_hpo-7_pd Subfamily hpo-7 741-941 6.2e-11 36.7 In-house 36-229 (263) alignment 
Range on Protein: 741-941
Range on HMM: 36-229/263.0
KKHQFIAtqgpLPQTLVDFWRLIWQEDICCILMmLSITSDGGIVRCQQYWPDAIGVAAFYGPFKIIVEGINDnkvseERIIK-LSMTSSSSSDNSHKTIH
.|  ..     | ||.  |.. | |     . | |.   . |...|..|.|        .   .. .  . .     . ..| | ..|  .     .|..
rknlysl....lvqtidkfyqtivqtktevvvm.LcDfneegvekcssyfPlekdekqklanvnvcttkvqs.....dvllktlellstlgeKkkthtvk

HYLFKCWPDHGVPATPTSThsfYEQIKMWLDLpPPVLIHCSGGIG------VTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHY
|| .| |...  |  . .    .. .|.  ..  .. .||| |||      |. ..   ||   .  ||...| . .....||.|   |.|  |  |  .
hysykgWiekndpelarei...lnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsil

VLLEAFYT
..|. .. 
mvLdfvln
subfamily_eak_pd Subfamily eak 681-853 7.2e-11 36.0 In-house 35-196 (332) alignment 
Range on Protein: 681-853
Range on HMM: 35-196/332.0
LQNFGHLFSTEVANCSENKKRNrFKTILPYDNNLLTLRPISSRgdcSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSiTSD
|... .| | ....  |. .||    |.||| .|. | .          ||||| ..  .  ...| |  .  . .  ||... ..   .|...|    .
lddyqrllsisetarleavnrn.vvkivpydrylvrltssqln...rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlle.dve

GGIVRCQQYWPDAIGVAAFYGPFKIIVEGINDNKVSEERIIKLSMTsssssDNSHKtIHHYLFKCWPDHGVPA
 .. . ..|.||       .| ...       ... | | ..||.      ...|. ..|| .  | .  .| 
lkleksdkyfpdktreelkfGildverkefvkrniletrllelskG.....nethr.vlhykvfGwtettlpk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 695-792 1.1e-10 35.4 In-house 45-155 (349) alignment 
Range on Protein: 695-792
Range on HMM: 45-155/349.0
CSENKKRNRFKTILPYDNNLLTLR--PISSR----------GDCSHSYINASYID--GYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILmMLSITSD
  |   .||.| ||||.   . |.  . ||.          .   . |||| |.    .. ....|||| ||| |. ||...|  . .  .|  |.   .
GvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvl.sLnddke

GGIVRCQQYWPD
 .. .|..|| .
lslekcdiywqe
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 958-1231 1.1e-10 35.6 In-house 15-279 (303) alignment 
Range on Protein: 958-1231
Range on HMM: 15-279/303.0
RLGKHDEILNMNRYEahykalQVLTVKPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKktEDFIHASYINGYQEaRSFIVAESPTKLTAANFWSMIVK
|. ..|  . .| .|      .| .  | || .|  ..|.   |    .  |  .| |      .|||||..   . .  |... |   |||.|| ||..
rtldedaniavnefe......kvvsylppsvsknqfvknmdknrfvdvicldhskvklsd..ssyihasyleldss.kkailtqlplshtaadfwqmiie

NKCSVIVMLCDIVEMEVDTCYQYWPATYDSErHFDFYRIKHHEMNIDNYYTQTILRVLDTQAGEEQTIILIQLpLSNIVSDELSHTERVGILSAIQEIEK
.|  ....|    |..       .|   |   .|.   |.  |..  .      |.||    |. .... ..    .   ...       ..  | ... 
qkvkcvlllltdseydklggdsvfprnqdfl.kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhh.ykawphnsipsdgspkfvkqiwqlqs

IQRKTG-NNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQ-VNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
. ||   ..| .      . |.| |... |.   .. ||  ...   | |.|  .   .    |. .|| ||  .|
vlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_CG42327_pd Subfamily CG42327 874-936 1.6e-10 35.2 In-house 249-312 (319) alignment 
Range on Protein: 874-936
Range on HMM: 249-312/319.0
PVLIHCSGGIGVTGMLISIMIGIEQgLSTG--GVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLL
|. .||| |.| ||..|.  | |.. | .    ||.  .|  .| .| . ..| |||.|.. || 
PlvvhcsdGvGrtGlviasdiairs.leeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 872-936 1.8e-10 35.2 In-house 228-292 (297) alignment 
Range on Protein: 872-936
Range on HMM: 228-292/297.0
PPPVLIHCSGGIGVTGMLISIMIGIEQGLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVHYVLL
. ..|.||| |.| .|...  .. ...       || ||....|.||  ..|| ||..... . |
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1011-1230 2.6e-10 34.5 In-house 58-275 (312) alignment 
Range on Protein: 1011-1230
Range on HMM: 58-275/312.0
YRVVLNKKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPAT---YDSERHfDFYRIKHHEMNID---
 |  |    . .||| ...       |.....| . |...|| . .   .. |..|| .||   . | .|        | | |   |     |..|    
grftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh.rvyteycteieiggks

-NYYTQTILRVLDTQAGEEQTIILIQLPLSNIVSDELSHTERVGILSAIqeiekiqrKTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEIL
 .  |. .|.|.   .|.|  .   |           |      .|||.        |  ..|.. |||  | |.| .... . |  ..  .. |. ...
kdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav........kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsf

YNMRTCKPGLITTPVQYKMVYLLLMRY
  .|  .   . .  || ..   .. .
vllrkdrarsvrvfpqyvyalrcvlef
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 697-783 5.4e-10 33.3 In-house 36-125 (347) alignment 
Range on Protein: 697-783
Range on HMM: 36-125/347.0
ENKKRNRFKTILPYDNNLLTLRPI---SSRGDCSHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICCILMMLSITSDGGI
 . ..|| |     |.  . | |     || | ...|||||.|   . ....| || |||.|. |||...    .  .. ..    |  |
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeai
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 653-750 1.5e-09 31.9 In-house 5-95 (95) alignment 
Range on Protein: 653-750
Range on HMM: 5-95/95.0
VKLSEFADHIeLLNKSNGGKGFKSEFQRLQNFGHLfSTEVANCSENKKRNRFKTILPYDNNLLTLrpiSSRGDcsHSYINASYIDGYKKKHQFIATQG
...| |  |. |  .||  . |  ||. ..      .  |     |  .|||  |.|||   ..|   ... |    |||| ..||| .|  .||.||
ihvsvfhshv.lemhsnsdqefdnefksismtsga.pytvgsseanipknrflnifpydatrvvl...ttkrd..sdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 727-851 1.3e-08 29.2 In-house 12-126 (130) alignment 
Range on Protein: 727-851
Range on HMM: 12-126/130.0
SHSYINASYIDGYKKKHQFIATQGPLPQTLVDFWRLIWQEDICcILMMLsitsdGGIVRCQQYWPDAIGVAaFYGpFKIIVEGINDNkvsEERIIKLS-M
 . |||||..    .  ... || || .| .|||... .  .  .|..|     | .   ..||||.  .  .|   .|||   . .   | . || | .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvn.vlvvl.....gsveeedeywpdsePle.wye.ediivtltdrd...efknikasnl

TSSSSSDNSHKTIHHYLFKCWPDHGV
  .|   .||...  .    ||  | 
eiesdlneshqaltmfqisnwpsdgt
subfamily_eak_pd Subfamily eak 1017-1116 1.4e-08 28.5 In-house 75-171 (332) alignment 
Range on Protein: 1017-1116
Range on HMM: 75-171/332.0
KKTEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDFYRIKHHEMnIDNYYTQTilRVLD
.  . .| || ..  .  | .|..  . .     || |....|   ||.| . ||....   .|.|     | .| .. ..  |  . .   .|  | | 
lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef.vkrnilet..rlle
0038934 (Phosphotyrosine protein) phosphatases II 839-932 1.5e-08 30.0 In-house 80-170 (194) alignment 
Range on Protein: 839-932
Range on HMM: 80-170/194.0
HHYLFKCWPDHGVPATPTSTHSFYEQIKMWLDLP--PPVLIHCSGGIGVTGMLISIMIgieqgLSTGGVDVMAIVNKMRSQRMNMIQTEEQYQFVH
 .||   .||.|.. .   ...|.. .. .|.      |..|| .|.| ||.|.   .     . . | .. . .. .|. | ..|.. .... ..
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdyleall
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 995-1086 5.5e-08 24.7 In-house 44-135 (327) alignment 
Range on Protein: 995-1086
Range on HMM: 44-135/327.0
SNLPlVRSDLYLPPDEYRVVLNKKTEDFIHASYINgyQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEME---VDTCYQYWPATYD
 ||| |   | .|  . | ||    |.|.   |.    |   .|. ..||| ..   | .|.|..  ..| ||   .|       || |.|.  .
knlp.vnvrlpipirdnrrvlcgsdeeffpgqyvr..megaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfptele
subfamily_PTEN_pd Subfamily PTEN 816-934 2.3e-07 26.0 In-house 60-175 (184) alignment 
Range on Protein: 816-934
Range on HMM: 60-175/184.0
SEERIIKLSMTSSSSSDNSHKTIHHYLFKcwpDHGVPATpTSTHSFYEQIKMWLDLPPP--VLIHCSGGIGVTGMLISIMIgIEQGLSTGGVDVMAIVNK
 . .|. | .  . .|.. .. ...| |.   ||  |      ... |.|..||.  .   | .||  | | ||.||.  . ....| .   ..... ..
dhykiynlrserkydskkfdgrvavypfd...Dhnpppl.elleeivediekwleedkknvvvvHCkaGkGRtGvlivayl.lkslllekaeealelfae

MRSQRMNMIQTEEQYQFVHYV
.|..  . ..   |  .|.|.
aRtknkkgvtiPsqrRYveYy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 836-937 2.6e-07 24.7 In-house 215-342 (350) alignment 
Range on Protein: 836-937
Range on HMM: 215-342/350.0
KTIHHYLFKCWPDHGVPATPTSTHSFYE-----------QIKMWLDLPPPVLIHCSGGIGVTGMLISIMIGIE---------Q-----GLSTGGVD-VMA
  ...  .| |.| ..   | |  .  |           .  .  .  .|.|.||| |.| ||.|...   ..         .        .   | .  
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

IVNKMRSQRMNMIQTEEQYQFVHYVLLE
|||..|.||..|.|. .|. |..  || 
ivnelrkqrismvqnldqfifiYeallf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1018-1093 3.1e-07 24.0 In-house 88-165 (349) alignment 
Range on Protein: 1018-1093
Range on HMM: 88-165/349.0
KTEDFIHASYING--YQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEMEVDTCYQYWPATYDSERHFDF
| .|.| | |..   ..  . .|    |   |  .|. .|. |.  ... | |  | ... |..||     |. .  .
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvkl
subfamily_CG42327_pd Subfamily CG42327 1161-1231 4.3e-07 23.9 In-house 244-315 (319) alignment 
Range on Protein: 1161-1231
Range on HMM: 244-315/319.0
KTGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIE-QQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRYV
.  . |. ||||| | |.|.      .|....   . |.| .... .|  .   . |  ||...|  |  | 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_PTPDC1_pd Subfamily PTPDC1 835-932 5.4e-07 24.2 In-house 80-169 (182) alignment 
Range on Protein: 835-932
Range on HMM: 80-169/182.0
HKTIHHYLFkCWPDHGVPAtPTSTHSFYEQIKMWLDLPpPVLIHCSGGIGVTGMLISIMIGIEQGLSTggvdvMAIVNKMRSQRMNMIQTEEQYQFVH
.. | .| |  |.|.||..  ..       ... |.    | .||  | | ||.||. ..   . |..        ....||.| . ||| || ..|.
eqgiyvynf.gwkDygvas.leriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrlta.....ekaiklvrskrpksiqtreqvelvk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1168-1223 6.6e-07 23.6 In-house 2-57 (69) alignment 
Range on Protein: 1168-1223
Range on HMM: 2-57/69.0
LVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMV
.||||    |.| |  .   . ..| |. |.|.. .  || |.| ..   ..| ..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1009-1072 1e-06 22.5 In-house 47-113 (332) alignment 
Range on Protein: 1009-1072
Range on HMM: 47-113/332.0
DEYRVVLNK--KTEDFIHASYINGYQEARSFIVAESPTK-LTAANFWSMIVKNKCSVIVMLCDIVEM
|  || |      .||  ||...|| .  ..|.|..| .  |   || |. . | |.|... || | 
dhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek
subfamily_CDKN3_pd Subfamily CDKN3 837-932 1.9e-06 21.6 In-house 101-189 (202) alignment 
Range on Protein: 837-932
Range on HMM: 101-189/202.0
TIHHYLFkcwPDHGVPAtPTSTHSFYEQIKMWLDLPPPVLIHCSGGIGVTGMLISIMIGI-EQGLSTggVDVMAIVNKMRSQRmnMIQTEEQYQFVH
..||| .   .| .||  ..|   . |.... |.     |.|| ||.| . ..|. .. . .. ..    | .. . ...  |   |||  ||....
ivhhypi...adglvpd.iasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiep..kdaidklrdlkgsr..aiqtvkqynyls
PTEN_1 838-934 1.9e-06 22.8 In-house 95-188 (196) alignment 
Range on Protein: 838-934
Range on HMM: 95-188/196.0
IHHYLFkCWPDHGVPATPTSTHsFYEQIKMWLD-LPP--PVLIHCSGGIGVTG-MLISIMIGIEQglsTGGVDVMAIVNKMRSQRMNMiqTEEQYQFVHY
. .. |  ..|||.|      . . .... ||  .|.   ||.|| .|.| .| .... ..  ..       . ...|...|....    . .| ....|
veylhf.pieDhgapslselfd.icksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk...ltadeAlelvrekRppgapn..spsqerlley

V
.
f
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 984-1084 3.3e-06 20.9 In-house 84-181 (244) alignment 
Range on Protein: 984-1084
Range on HMM: 84-181/244.0
KPNSVLRNFGLSNLPLVRSDLYLPPDEYRVVLNKKT--EDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIVEmEvDtcyQYW
 |. .   |  .|    |    || |  || |.| .  . .| ||..     .  .|... |   |. .|| |... .  |.|.|  . | | |   .||
dpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.e.d...eyw

PAT
| .
pds
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1155-1230 3.6e-06 21.0 In-house 218-294 (297) alignment 
Range on Protein: 1155-1230
Range on HMM: 218-294/297.0
IEKIQRK-TGNNPILVHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYLLLMRY
.| .. .   | ..|||||  | ||||     . ..... ..  ..  ||  .|  .. |. |  |....| . .. 
leslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 656-738 3.7e-06 20.5 In-house 9-85 (440) alignment 
Range on Protein: 656-738
Range on HMM: 9-85/440.0
SEFADHIEllnKSNGGKGFKSEFQRLQnFGHLFSTEVANCSENKKRNRFKTILPYDNNLLTLRPIssRGDCSHSYINASYIDG
..|||...   ..   . |. |.  |   |    ...|.  .|| .||.. || ||.. . |  .  .|  .  |||||||.|
adfadyvq...nnrrsrafedewsllp.sglsqpsdiaslpnnkvknryrnilaydhsrvmleev..kgvpdsdyinasying
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1169-1223 4e-06 21.1 In-house 2-56 (69) alignment 
Range on Protein: 1169-1223
Range on HMM: 2-56/69.0
VHCSDTVSRSGVFCVLYTSIQQMKIEQQVNIYEILYNMRTCKPGLITTPVQYKMV
||||    |.| |  .   . ..| |. |.|.. .  || |.| ..    .| ..
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1019-1088 5.4e-06 20.0 In-house 220-286 (440) alignment 
Range on Protein: 1019-1088
Range on HMM: 220-286/440.0
TEDFIHASYINGYQEARSFIVAESPTKLTAANFWSMIVKNKCSVIVMLCDIvemEVDTCYQYWPATYDSE
|.       ..||    .|| .. |   |  .|| ..   . | |.|| ..   .  ||  |||    | 
tdksplqqefegyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsv
subfamily_DSP1_pd Subfamily DSP1 1150-1195 8.2e-06 20.0 In-house 83-127 (163) alignment 
Range on Protein: 1150-1195
Range on HMM: 83-127/163.0
SAIQEIEKIQRKTGNnpILVHCSDTVSRSGVFCVLYT-SIQQMKIEQ
 .|. |.....| |   .|.||   .|||  .|..|  . .....|.
eviefidevkkknGk..vlihCqaGisRsstlclaylmktkrvslee
0038934 (Phosphotyrosine protein) phosphatases II 1147-1225 9.1e-06 20.9 In-house 98-171 (194) alignment 
Range on Protein: 1147-1225
Range on HMM: 98-171/194.0
GILSAIQEIEKIQRKTGNNPILVHCSDTVSRSGVFCVLYTsiqqmKIEQQVNIYEILYNMRTCKPGLITTPVQYKMVYL
 .|. .. .... ..  .. ..|||   ..|.|.... |         .. .  | .. .| ..|| | .. ...... 
illrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdyleallk