Gene PTPRD-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP073_AA protein Get Run
AqueP073_AA_365-647 phosphatase_domain Get Run
AqueP073_AA_660-927 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 359-928 7e-269 888.2 In-house 1-564 (564) alignment 
Range on Protein: 359-928
Range on HMM: 1-564/564.0
THPTIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPM
....|.......|.| ...|....|.||. .| ... ...|.||...| |||||.||..|||.||.||.|...||||||||||.||..|...|||||||.
sskpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

AETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvNeRCTYGGVEVTLVECVPLANYTFRTFTImKGGTSKDLREVRQFHFTAWPDHGVPEFPT
|||| .||||||||||.||||.|||.||..|||..|||.. . ..|||...|||.|.. ||.|..|||.. |  .|.. |||||||||.||||||||..|
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesat

SMLSMIRCVRAHHNrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQF
|.|..||.|||...   ||.||..|||||||||||||.|||.||.|| . |..||||..|..||.|||.|||||.||.||||||.||.|||.|.|.|...
slLdlirkvralne...pdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenl

PVHLDKLELIQEDGESSLLEMEFQRLA-TDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNT
  ||.||. ..|| |.. ||.|||||| ....|...||.|||..||.||||.||...|..||.||.|||.|.||||||||...||..||..|||.|.|||
kqhlqkLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplknt

VEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQM
|||||||.||...||||||||||||..|.|..|.||||....|||||...||||..|.|.|..|....|..||.|.||..|........|..|.|.||..
vedfwrmvweeevkiivmltkleekleeesseyysdleatkyGeitikvlkkkeksdilfrkkkvevkekseavyllhtvqavdkklltvidsvldllka

IQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLSQK
...|.|.....|..|..||...|||...........||...|||....|.|.||.|.|..||..||.|..|
vrkvleravvvrvsegvtvtgasgvlfatlervklevlldvsvearllltqrvkllsildsarlqtelilk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 366-684 2.1e-112 370.3 In-house 5-318 (318) alignment 
Range on Protein: 366-684
Range on HMM: 5-318/318.0
YQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKE-VANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGE
 ..  |.. .|.. .  . ||.  .  .. .. .  .. ..| ||||| |||.||||||||.... .||||||||...||... ..|||.|.|..||| .
edleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieD

FWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvnERCTYGGVEVTLVECVPLANYTFRTFTIMKgGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMI
|||||||||||.|||.|...|.. .|.. ||| .  .  .|| . |.| | | |..|. |.|.. .   ... |.|||.|.|.|||.|||| ..|.|...
fWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlv

RCVRAHHnrLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDK
| |.. .  .....||..|||||||||||.|...|..|.|| . |  ||... |. ||.||| |||||||| ||.... ||.|.| |.| ....  .. .
rqvskaq..qksgagpivvhCsaGvGrtGvfiavdilleri.kaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire

LELIQEDGESSLLEMEFQRL
|.  . .   . ...|||||
lreqdpesgttemdaefqrl
subfamily_PTPRB_pd Subfamily PTPRB 362-646 1.1e-103 341.3 In-house 6-285 (293) alignment 
Range on Protein: 362-646
Range on HMM: 6-285/293.0
TIHNYQFPAHLAVMRMNDNQRFMEEFGTIP-MNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAE
 |.  .| .|.. |. ... ||.||. ..  ..  . ...|. ..| ||||| |||||||.||||...| ..|||||||....|.  |...||||||. |
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNErCTYGGVEVTLVECVPLANYTFRTFTIMKggtSKDLREVRQFHFTAWPDHGVPEFPTSM
|. .|||||||..| .|||.|.| ||  |||. |||.| .. ..|| ..||||.   | ... |...| |   .|. |.|||.|||.|||||||| ....
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeep.vlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktl

LSMIRCVRAHHNRlPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
|...| || ....   ...|..|||||||||||||. .| .||.| . || |||.| |. ||..||..||||.|| |||... . .
ldfvrtvreaiek.taskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldll
0050432 (Phosphotyrosine protein) phosphatases II 371-651 1.8e-98 325.0 In-house 32-304 (308) alignment 
Range on Protein: 371-651
Range on HMM: 32-304/308.0
HLAVMRMNDNQRFMEEFGTIPMNPGHPK-EVANYECNLAKNRYDNILPYDHTRVKLstvkwQEGSDYINASFLDGF--MKPQQYIATQGPMAETIGEFWR
. ......|.....||| ...... ... .||. ..|  |||| .||||||.||||     .|||||||||. ||.   .|...||||||. .|.. |||
lkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVN-ERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkDLREVRQFHFTAWPDHGVPEFPTSMLSMIRC
||||||. .|||.|||.|.. .||. |||.... .  .||.. |||...  |..|| ||..... |.. . |.|..||.|.|||||||. |...|.... 
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflel

VRAHHnrlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVT
|| ..     . ||..|||||||||||||...| .|... ..  .||... |  || ||..||||..||.|...|. | . . .|
vrksl.....pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0051299 (Phosphotyrosine protein) phosphatases II 362-646 4.2e-98 323.6 In-house 4-286 (288) alignment 
Range on Protein: 362-646
Range on HMM: 4-286/288.0
TIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPK-EVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAE
 |.  ..  ..  ...|.. ...||| ... .  ...  .|....|| |||| .||||||.|||||... .|||||||||..||. .....||||||. .
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTdvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGG---TSKDLREVRQFHFTAWPDHGVPEFP
|...|||||||||. .|||.|||.|.. .||. |||.  ..  ||| . |||.... |..|| ||... . .    ..  |.|..||.|.|||||||. |
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TSMLSMIRCVRAHHNrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
...|...| || ...   .. ||..|||||||||||||...| .|......   ||... |  ||.||..||||..|| |..||. |..
ellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 367-683 6.3e-98 323.2 In-house 4-313 (317) alignment 
Range on Protein: 367-683
Range on HMM: 4-313/317.0
QFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFW
... .|  . ..|.....||| ... .. .. .||....|  |||| .||||||.||||| ..  ..|||||||. ||. .....||||||. .|.. ||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMVWEQNSATIVMVTKLQEKSTVKCDCYWPTdvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkDLREVRQFHFTAWPDHGVPEFPTSMLSMIRC
||||||.. .|||.|.| |.. .||. |||.  .|  |||.. |||.... ||..| ||... . |.| . |.|..||.|.|||||||. |...|.... 
rmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgds.esrtvthfhytgWpdhgvppspdllldflea

VRAHHNrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEdNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKLE
||.. .   .. ||..|||||||||||||.... ||... ... .||..  |  ||.||. .|||..|| |...|..| . ...|..   .....|.|| 
vreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkll

LIQEDGESSLLEMEFQR
 .   ....| |.|...
iplalddvklkekelkl
subfamily_PTPRA_pd Subfamily PTPRA 373-679 7.5e-98 322.4 In-house 24-328 (330) alignment 
Range on Protein: 373-679
Range on HMM: 24-328/330.0
AVMRMNDNQRFMEEFGTIPM-NPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWE
 .   .||..| ||| ..|  .     |.|. | |  |||. ||||||..|| ||... .| ||||||||.||. . ...||.||| .||. .||||.||
rirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiwe

QNSATIVMVTKLQEKSTVKCDCYWPTDvnERCTYGGVEVTLVECVPLANYTFRTFTIMK---GGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVR
|.||||||.|.|.|.   ||  |||..     ||| . |.. ... | .|| | | . .   .   |. | |||||||.||| |||  |  ||.... |.
qksativmltelkerkeekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk

AHHNRlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKLELI
. ...    .||..|||||||||||||.|.|..|.|. . |  ||... |  ||.||  ||||. || ||.... |    | |..    .  ||.||   
klnqq...sagpivvhcsaGvGrtGtfivldavlerv.kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynk

QEDGESSLLEM
  . .   || 
itgtdkiglee
subfamily_PTPRG_pd Subfamily PTPRG 366-658 5.5e-97 320.3 In-house 4-299 (563) alignment 
Range on Protein: 366-658
Range on HMM: 4-299/563.0
YQFPAHLAVMRMNDNQRFMEEFGTIP--MNP-GHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGS-DYINASFLDGFMKPQQYIATQGPMAET
 .|  |.| .  .....| |||  .   ...   . | .. ..|  |||| ||..||..||||| .  .... |||||...||. | ...||||||...|
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

IGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTdvNERCTYGGVEVTLVECVPLANYTFRTFTIMK----GGTS-KDLREVRQFHFTAWPDHGVPEF
.  ||||.||||.|.|||.|.|.|.   ||| |||.  .|  ||| ..|||.|   || || ||..| .     . . .. ..|||.|.| ||||||||.
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

PTSMLSMIRCVrahHNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSD
..  |....         . ..||..||||||||||||..|.|..|..| . |. |...| .  .| ||||.||||.|| |.|.|. |||| . |.....
slpvLifvkks...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellae

QF
| 
qv
0046845 (Phosphotyrosine protein) phosphatases II 383-651 1.4e-96 318.5 In-house 2-279 (284) alignment 
Range on Protein: 383-651
Range on HMM: 2-279/284.0
FMEEFGTIPMNPGH---PKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQ-EGSDYINASFLDGF-----MKPQQYIATQGPMAETIGEFWRMVWEQN
..||| .....  .   . .||....|| |||| .||||||.||||.... . |.|||||||..||.     ......||||||. .|...|||||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SATIVMVTKLQEKSTVKCDCYWPTDvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNR
. .|||.|.| |.. .||. |||.. .|  |||.. |||...    .|| ||... . |...  |.|..||.|.|||||||. |...|...| || ....
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

lPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGED--NVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVT
  |. ||..|||||||||||||...| .|... ....  .||... |  ||.||..||||..|| |..||. |.. ...|
.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 370-682 1.5e-95 315.0 In-house 12-319 (319) alignment 
Range on Protein: 370-682
Range on HMM: 12-319/319.0
AHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMV
 .|  .. . .. . .|| .. .      . |. | |  |||| |||.||.|||.||... .||||||||||.||. . ...||||.|...|| .|||||
erlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmv

WEQNSATIVMVTKLQEKSTVKCDCYWPTDvnERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRA
||..| ..||.|||.||  ||.  |||.   .  .|| . ||| |   |..|  | ... |  .  . ||| .|..|.||||.|||  ||.| ... .| 
Weeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

HHNRlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKLELIQ
 ...  .. ||..|||||||||||||.|.| ||.|. . |  .|..  |  || |||.|||...|| ||.||. ||. .| |..  ...   | .|.  .
srek..tqsgPivvhCsaGvGRtGtfivldamlerv.keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekv

EDGESSLLEMEFQ
 |   . || |||
adtgetglerefq
0036941 (Phosphotyrosine protein) phosphatases II 374-656 3.9e-94 310.6 In-house 6-287 (297) alignment 
Range on Protein: 374-656
Range on HMM: 6-287/297.0
VMRMNDNQRFMEEFGTIPMNPG-HPKEVANYECNLAKNRYDNILPYDHTRVKLstvkWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQ
............|| ... .    ...||....|| |||| .|||||||||||     .|||||||||..||.  ....||||||. .|...||||||||
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

NSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVP--LANYTFRTFTIMKGGTSkDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAH
|. .|||.|.| |.  .||. |||....|  |||.. |||...    |..|| ||... . |.. . |.|..||.| |||||||| |.|.|..|. || .
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkv

HNRLPPDtGPMIVHCSAGVGRTGTFVVIDSMLQRILH--GEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSD
.. ||.. ||..|||||||||.|||...| |||.. .   | .|||.  |  ||.||...|||..|| |..||. | . .. |..  .
lkllpsg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll
subfamily_PTPRK_pd Subfamily PTPRK 360-682 4e-94 310.0 In-house 1-313 (314) alignment 
Range on Protein: 360-682
Range on HMM: 1-313/314.0
HPTIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNpghpKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMA
||.|.      ..|... ...  | ||. ...       ..|. . | .|||. .||.||..||.| |.. .  ||||||...|.. .|...|.||||. 
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNErctYGGVEVTLVECVPLANYTFRTFTIMK-GGTSKDLREVRQFHFTAWPDHGVPEFPT
||. .|||.|...|.|.|||.|.|.|.. |||  ||| | .    || ..|.|||. .||..  |.|.. |   . .. ||||||.|..||||.||   |
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsat

SMLSMIRCVRAHHNRlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQF
..|...| | ....    . |...|||||| ||||||..||..|. | . |. ||..  |  ||...  ||.||.|| ||...| ||  || | .   .|
gllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldmi.eregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsef

PVHLDKLELIQEDGESSLLEMEFQ
     .   .. . .|| |. |||
kalylesirldpqtnssqlkeefq
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 365-653 5.3e-93 306.5 In-house 11-297 (298) alignment 
Range on Protein: 365-653
Range on HMM: 11-297/298.0
NYQFPAHLAVMRMNDNQRFMEEFGTIPMNPG----HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAE
. ...   ||.. ..  .. .|| ..         . ||||... |  |||| .|...|..|| |.... .| |||||||||... . . .||||.|. |
kaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlte

TIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNErcTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkDLREVRQFHFTAWPDHGVPEFPTSM
|. .|||||.|....||||.|.|.|. ..|.  |||.. .|  ||| ..|.| .    |... |.... |  .. . |||||.||| |||.||||  ||.
tvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsv

LSMIRCVRAhhNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDV
| ..| |||  ..      |.||.|||||||.|||..|||.|.|. . |  ||..  |  ||..|  .||||.|| ||.||. ||.... ...
ldllrkvra..sqqqagnkpvivqCsaGvgRsGtfiaidsvlerv.kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0047943 (Phosphotyrosine protein) phosphatases II 374-646 3.6e-92 304.0 In-house 5-272 (273) alignment 
Range on Protein: 374-646
Range on HMM: 5-272/273.0
VMRMNDNQRFMEEFGTIPMNPG-HPKEVANYECNLAKNRYDNILPYDHTRVKLstvkWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQ
...........||| ... ..  ....||....|. |||| .||||||.||||     ..||||||||..||. .....||||||. .|...||||||||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NSATIVMVTKLQEKSTVKCDCYWPTDVNE-RCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKdLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHH
|. .|||.|.|.|.. .||. |||....|   ||| . |||...   ..|| ||... . ||..  |.|..||.| |||||||. ..|.|..|. || ..
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkal

NRLPPDtGPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
. || . ||..|||||||||||||...| .|... ..  .||..  | |||.||  ||||..|| |..||. | .
ealpsn.gpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 358-646 2e-91 302.2 In-house 4-304 (307) alignment 
Range on Protein: 358-646
Range on HMM: 4-304/307.0
NTHPTIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPG---HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQ-EGSDYINASFL--------DGF
.... |  ...  .....  ...... .|| ...       .. ..|....|  |||| .||||||||||||... . |.|||||||.         ||.
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

MKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHF
 .....||||||. ||. .||||.|||.. .|||.|.| |.  .||. |||.. .|  ||| . |||..   |..|| ||...   . ..  |.|..||.
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

TAWPDHGVPEFPTSMLSMIRCVRAHHNRLpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDN--VDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
|.|||||||... ..|..|. ||.....| |. ||..|||||||||||||.... ||... ...    ||..  | |||.||  .||...|| |..||. 
tgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

EAI
| .
ell
0039614 (Phosphotyrosine protein) phosphatases II 359-650 7.2e-91 300.0 In-house 10-293 (297) alignment 
Range on Protein: 359-650
Range on HMM: 10-293/297.0
THPTIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHpKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQ-EGSDYINASFLDGFMK-PQQYIATQG
....|.   ....| ....|.......|| ... ..   ...|. ..|  |||| .||||||.||||.... . ..|||||||..||. . ....|||||
esipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PMAETIGEFWRMVWEQNSATIVMVTKLQEKSTvKCDCYWPTDVNercTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkdlREVRQFHFTAWPDHGVPEF
|. ||.. ||||||||.. .|||.||| |..  ||. |||....   |||.. |||...  |..|| ||... ..| |   |.|..|..| |||||||. 
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges...rtvthfqytgwpdhgvpps

PTSMLSMIRCVRAHHNRLpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGV
....|.... || ....| |. ||..|||||||||||||.... ||... ..  .||..  |  ||.||. .|||..|| |...|. | . ...
lellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 367-666 1.2e-90 298.7 In-house 8-303 (305) alignment 
Range on Protein: 367-666
Range on HMM: 8-303/305.0
QFPAHLAVMRMNDNQRFMEEFGTIPMNpGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFW
.. |..  .|..... . ... ..... ... .| . | | ||||. .| ..|. |..|.. . .. |||||||..||. . ..||..|||. .|. .||
dlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfW

RMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRC
|...|    ||||.|||.|    ||  |||. ..|.  .| ..|.| .    ..|. | ..| .  ..|. | | |...| |||||||.|.||.||.|. 
rliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikr

VRAHHNRlppDTG-PMIVHCSAGVGRTGTFVVIDSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKL
|. ....   | | |..|||||||||||.|...| .|.| |. |. ||... .  ||..|  |||| ||| |.|.|..| | || |..  . . ....||
vqkdqkk...dkgvpllVhCsagvgRtGvfiavdialer.lkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl

E
.
k
0043336 (Phosphotyrosine protein) phosphatases II 365-644 1.8e-89 295.2 In-house 4-275 (278) alignment 
Range on Protein: 365-644
Range on HMM: 4-275/278.0
NYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGE
  ... .|. . .|.......|| ... ..  ....|....|  |||| .||||||.||||| ..  ..|||||||..||. .|...||||||. ||.. 
vkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPtdvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDlREVRQFHFTAWPDHGVPEFPTSMLSMI
|||||||... ||||.|.| |.. |||. |||   ..  |||.. |||...  |..|| ||... . |...  |.|...|...|||||||| ....|...
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldfl

RCVRAHHNrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEdNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
. || . .   .. ||..|||||||||||||.... .|... ..  .||..  |  ||.||  .|||..|| |..||. |
kavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 368-646 5.7e-89 293.0 In-house 9-279 (288) alignment 
Range on Protein: 368-646
Range on HMM: 9-279/288.0
FpAHLAVMRMNDNQRFMEEFGTI-PMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFW
  |. | .  .... | ||. .. ...  . .....   |  |||| ||||||..||||  .. ..|.||||||..||  | ..|||||||.|.|...||
v.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkdlREVRQFHFTAWPDHGVPEFPTSMLSMIRC
..|.|... ||||.|.| |.   ||. |||.. ..   || |.|||||   | ... |.. . | .|    .|. |....|||||||||  . .| ..| 
elvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrklllekkkte...leitqyqylaWpdhgvPeskapllellrq

VRAHHNRlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
|   ..    ||||.||||||||||||||...| ..... . || .|. | |. ||.||...|||. || ||.|.. . |
vkvanqa...dtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllsli
DSPc_SM00195 384-646 3.1e-88 290.9 In-house 3-262 (263) alignment 
Range on Protein: 384-646
Range on HMM: 3-262/263.0
MEEFGTIPMN-PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTK
 ||| .. .. . .... |. . | .|||| ||||||||||||.. . .||||||||....|  |...|||||||. .|. .|||||||... .|||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLA-NYTFRTFTIMKGGTsKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLppdTGPM
 .|.   ||| ||| . ..  |.| ..|.|||.     ... ||... | |. .. |.|.|.....|||||||. ..|.|...| |. ....    .||.
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

IVHCSAGVGRTGTFVVIDSMLQRILHGEDnVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
.||||||||||||||.||..|... .... |||   |. ||.||  ||||..|| ||.||| |.|
vVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 384-646 3.1e-88 290.9 In-house 3-262 (263) alignment 
Range on Protein: 384-646
Range on HMM: 3-262/263.0
MEEFGTIPMN-PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTK
 ||| .. .. . .... |. . | .|||| ||||||||||||.. . .||||||||....|  |...|||||||. .|. .|||||||... .|||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLA-NYTFRTFTIMKGGTsKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLppdTGPM
 .|.   ||| ||| . ..  |.| ..|.|||.     ... ||... | |. .. |.|.|.....|||||||. ..|.|...| |. ....    .||.
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpi

IVHCSAGVGRTGTFVVIDSMLQRILHGEDnVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
.||||||||||||||.||..|... .... |||   |. ||.||  ||||..|| ||.||| |.|
vVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Ptp69D_pd Subfamily Ptp69D 362-665 2.9e-87 287.6 In-house 3-305 (307) alignment 
Range on Protein: 362-665
Range on HMM: 3-305/307.0
TIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMN-PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAE
.|.  . .  | . . . .. ...|. ... .   .  .|.. . |. ||||..| ..|.|||||.... .| ||||||||. |. . ...|| |.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvnERCTYGGVEVTLVECVPLANYTFRTFTIMKGG----TSKDLREVRQFHFTAWPDHGVPEF
|||.||||..||.. .|||...|.||.  ||. ||| .  . . || . |.||.     .|. |.. . | .      .| |.| |.|.|.|.|  ||| 
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

PTSMLSMIRCVRAHHNRLppdTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSD
....| .|. || ...      .|..|||||||||.|.|| .||.||.. . ||.|||.  |  ||.|||..||  .|| |.. |. . .  | ||.. |
argllklieqvrelykln...rsPivvhCsaGvgrsgifvaldsllqql.kaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvd

QFPVHLDKL
..  ....|
dledaierl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 379-665 7e-87 286.7 In-house 32-310 (319) alignment 
Range on Protein: 379-665
Range on HMM: 32-310/319.0
DNQRFMEEFGTIPMN--PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSAT
| ...  ||  ..    ..  .. || . |  |||. |||..|...|||  .  .|.||||||||..|. ....|||.|||. .|. .||||.||.|..|
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IVMVTklqeksTVKCDCYWPTDVNERCTYGGVEVTLVECVplANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLpP
||..|        ||  ||| .....   . |.|..||    |.|. | . . . |  || |...||||  |||.|||..|. .. ... ||  ...   
ivllt......kdkcsqywplkivikeerfkvkvdsveet..aeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske.n

DTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKL
.  ...|||||||||||...|.| .|.|. . |. ||.|  |  ||.||| .||   ||.||. |. |    | .||.  .||..|..|
hranivvhcsaGvGrtGvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 660-924 1.2e-86 285.6 In-house 9-266 (318) alignment 
Range on Protein: 660-924
Range on HMM: 9-266/318.0
VHLDKLELiqeDGESsLLEMEFQRLATDRTEPHRFASaTKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVE
 |. .|.    .||  ||. |..||. .. .. .. | ...||| |||..||..|.  ||||. .  .||||||||.||| ||...||.|.|.|. .|.|
shvrrlre...sGel.llseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetie

DFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHlEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQ
|||||.|| .|..|||||..||. ..    || . .||..|....|| ...|  ||. |.||. . .. |.| . . ...  ||..||| |.  ||....
DfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvr

NVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
.|..   .  ...||.| ||.||||||||||. |.|||   |...|.|||||.|| || .||||.
qvskaqqk.sgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqte
Y_phosphatase Protein-tyrosine phosphatase 406-643 3.3e-86 283.9 Pfam-A 1-234 (235) alignment 
Range on Protein: 406-643
Range on HMM: 1-234/235.0
NLAKNRYDNILPYDHTRVKLstVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTY
|. |||| .|||||.|||||   . .. ||||||....|. .....||||||. .||..||||||.... .|||.|.|.||. .||. |||.. .| .||
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GGVEVTLV--ECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHnrlPPDTGPMIVHCSAGVGRTGTFVVIDSMLQ
| ..|.|.  |.   ..||.|.... | ..... |||.|.|.|.|||||||| |.|.|..|| |. ..    ...||..||||||||||||||..| .|.
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldille

RILHGEDnVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
.. ..|. ||..  |  ||.||. |||...|| |...|| 
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 406-643 3.3e-86 283.9 In-house 1-234 (235) alignment 
Range on Protein: 406-643
Range on HMM: 1-234/235.0
NLAKNRYDNILPYDHTRVKLstVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTY
|. |||| .|||||.|||||   . .. ||||||....|. .....||||||. .||..||||||.... .|||.|.|.||. .||. |||.. .| .||
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GGVEVTLV--ECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHnrlPPDTGPMIVHCSAGVGRTGTFVVIDSMLQ
| ..|.|.  |.   ..||.|.... | ..... |||.|.|.|.|||||||| |.|.|..|| |. ..    ...||..||||||||||||||..| .|.
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldille

RILHGEDnVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
.. ..|. ||..  |  ||.||. |||...|| |...|| 
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 396-665 1.9e-85 281.8 In-house 15-274 (284) alignment 
Range on Protein: 396-665
Range on HMM: 15-274/284.0
HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTklqeksTVKCDCYW
  .. || . |  |||. .||..|...|||  .  .|.||||||||. |. ....|||||||. .|. .||||.||.|..|||..|        ||  ||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PTDVNERCTYGGVEVTLVECVplANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLpPDTGPMIVHCSAGVGRTGTF
| .....   . |.|..||    ..|. | . . . |  || |..|||||  |||.|||..|. .. ... ||  ...   .  ...|||||||||||..
plkivikeerfkvkvdsvees..eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske.nhranivvhcsagvgrtgvy

VVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKL
.|.| .|.|. . |. ||.|  |  ||.||| .||   ||.||. |. |    | .||.  .||..|..|
ivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
0045098 (Phosphotyrosine protein) phosphatases II 386-648 3.6e-85 281.0 In-house 13-274 (278) alignment 
Range on Protein: 386-648
Range on HMM: 13-274/278.0
EFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKlstvkwqegsDYINASFLDGFmkPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQE
 .  .....    ..|.|..||.|||| .||||||.|||          ||||||..||.  |...||||||. .|.  ||||.||... .|||.|.|.|
fefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelve

KSTVKCDCYWPTdvNERCTYGGVEVTLVECVPLANYTFRTFTIMKG---GTSKDLREVRQFHFTAWPDHGVPEFP--TSMLSMIRCVRAHHN--------
.. .||. |||   ..  |||...|||...  | .|| ||...       ..   |.|...|.. |||||||..|  .|.|.... .|....        
lgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

--RLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlhgEDNVDIYGHVTLLRNQRNF-MVQTEDQYFFIHEAINEAIAC
  .| .. ||..||||||||||||.|... ||...   |..||..  |. ||.||.. .||...|| |..|.. | . .
slllldsggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 359-681 1.3e-84 278.9 In-house 2-314 (315) alignment 
Range on Protein: 359-681
Range on HMM: 2-314/315.0
THPTIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPM
.|  |   |. ...|  . . .. | ... .||    || .||.   |  |||| ||..||..||.|  .. ...|||.||.|.||. |...|||.||| 
ahqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

AETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvneRCTYGGVEVTLVECVPLANYTFRTFTIMKGgtsKDLREVRQFHFTAWPDHGVPEFPT
......|||.|.|.. ..|||.|.| |.   |.. ||| .   . .|| . ||...     .|| ||.... |   ...||| |.|.|.||| |||.. .
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfg...dnirevvqlhytswpdmgvpkyti

SMLSMIRCVRAHHNRlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQF
... .|| |. ||.    . |...|||||||||||||. .|..|.. .. |. .|.|  .| .|..|  |||. .|| ||..|. |.. || | .. | .
plmnlirtvkqhhtn...svgaivvhcsaGvGrtGtfitldavldq.aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdly

PVHLDKLELIQEDGESSLLEMEF
  . | |     |  |.||. .|
lqrydsllapspdtgstllqeqf
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 367-686 2.3e-84 278.4 In-house 6-316 (515) alignment 
Range on Protein: 367-686
Range on HMM: 6-316/515.0
QFPAHlaVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFW
||||   | . .    | |||  .|    .|. ||. | |  |||| |||||| .||||  .. .  |||.|||.. .|   . |||.|||   .. .||
qfPaf..vnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfW

RMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGgtsKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRC
|.|...| .||.|||||.|   .||  |||    .   .| ..| ||     .. . |..|..||   .| | | ||||| |||.|||.  .|.| .|. 
rlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkg...ddsrtvtqfhfteWPdkGvpkhtssllklike

VRAHHNRLppdTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKLE
|.| |...   | |.|.|||||||||| .. |||.. ..  . . ||..  || .|..| ..|||..|| ||..|. | .    | .   .|  ||. | 
vkadhgqy...thpliihcsaGvGrtGvvisidsvvahaktt.rmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlh

LIQEDGESSLLEMEFQRLAT
   .    | .  ||| | .
ssgdgrgrskmtkefqtlks
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 665-931 4.2e-84 277.3 In-house 14-275 (319) alignment 
Range on Protein: 665-931
Range on HMM: 14-275/319.0
LELIQEDGEsSLLEMEFQRLATDRTEphRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRM
|. ... ||  ||| ||. | .  ..   | ||.|. || |||. ||..|.  ||.|| .  .|||||||||.||.|.......|||.|..||.||||||
lkalastge.tllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrm

IWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQEL
.||..| |.|||||| || .     ||.. .  ..|.....| ...|  ||  |..|. .. .   . .. |||.. ||. .|| .|. ||........ 
vWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirks

YiTLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRlSQKKIV
     .  ||.| || |||||| ||.| ..||| . ||..|.|.||..||.||  |||.  .| |..
r.ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp.eqYkfi
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 399-652 4.4e-84 276.6 In-house 2-247 (250) alignment 
Range on Protein: 399-652
Range on HMM: 2-247/250.0
EVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVkCDCYWPTD
.||.   |. |||| .|...|..|| | ..| .. |||||||||.|... . .||||||. .|| .|||||.|..|.||||.|.|.|.  . .  |||..
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

VNErcTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLppDTGPMIVHCSAGVGRTGTFVVI
. |  .||.| |.| .    |.|| |.. . |  . .| | |||.||..||| ||||  |..| ... |.| ...   ...|.||.|||||||.|.|..|
kae..kyGdvtvsllskeefadytkrklklska.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa..gnaPvivqCsaGvgrsGafiai

DSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACgVTD
|..|.| |. |  ||..  .  ||..|  .|....|| |..|.| .|. . | |
davler.lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds.ved
subfamily_PTPN6_pd Subfamily PTPN6 380-646 5e-84 276.9 In-house 25-297 (306) alignment 
Range on Protein: 380-646
Range on HMM: 25-297/306.0
NQRFMEEFGTI---PMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLStVKWQEGSDYINASFLDGFMK--PQQYIATQGPMAETIGEFWRMVWEQNS
.. |.||| ..    ..  . .. ..   |  |||| ||||.|||||.|.  .   |||||||..... .|   ..|||||| . .|. .||||||..||
kagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

ATIVMVTKLQEKSTVKCDCYWPTDVNERCtYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRL
  |||.||  |..  ||  |||.  ...  || ..|| |.   ||.|..|.... |  ..|. |||.|.||..|||||||. |  .|.... |......|
rvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

P-PDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHG--EDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
   ..||..||||||.||||||.||| .|. | .   . ..||.  | ..|.||. .||||.|| |...||.. |
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 371-646 2.5e-83 274.4 In-house 5-276 (281) alignment 
Range on Protein: 371-646
Range on HMM: 5-276/281.0
HLAVMRMNDNQRFMEEFGTIPM-NPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMV
||. .. |||. |.||. ..   . ... . .. . |  |||| ||  ||.||||..  . .. .|||||.|..|. ....|||||||. ... .||.||
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WEQNSATIVMVTKLQEKSTVKCDCYWPtDVNERCTYGGVEVTLVECVPLANYTFRTFTImkGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRA
|||.  .|||||.  |.. .||  ||| | |.. .|| | |. ..    |.|  |.|..    .| . |||.|...|||||||||. .. .|.  . |. 
weqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlk

HHNRlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
 ...      |...|||||||||||.. .| ..... . . ..|.   |. ||..||.||||  || |.. |. .|.
ltek..ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0040439 (Phosphotyrosine protein) phosphatases II 397-646 3e-83 274.5 In-house 2-246 (249) alignment 
Range on Protein: 397-646
Range on HMM: 2-246/249.0
PKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWP
...||....|. |||| .||||||.||||| ..  ..|||||||..||.  ....||||||. ||.. ||||.||... .|||.|.|.|.  .||. |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TdvNERCTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLpPDTGPMIVHCSAGVGRTGTFV
.  ..  .||.. |||...  ...|| ||... .    .. |.|.....| |||||||... ..|..|. || ....| |. ||..|||||||||||||.
l..ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfi

VIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
... ||... .   .||..  | |||.||. .||...|| |..||. | .
aaylmleqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeallell
0050432 (Phosphotyrosine protein) phosphatases II 662-924 1.4e-82 272.8 In-house 29-285 (308) alignment 
Range on Protein: 662-924
Range on HMM: 29-285/308.0
LDKLELIQEDGESSLLEMEFQRLATDRTePHRFASATKNVNKGKNRFVNIMPYEYNRVKLsfiraTEGSDYINASYIDSY--RQQRAYLATQGPMKNTVE
|| |.|...  ...|||.||..|    . .. . .| .  || |||...|.||...||||      ||||||||||.| |  ...|...|||||..||||
ldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntve

DFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL---ESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPeASYTLHHFQFLGWPERGVPVSALPLLQ
|||||.||.....|||||||.|...|  . || .    .|...| .|..|.. ... || .|.... .|. .  | |..||....||. ||| |. .||.
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilld

MIQNVQELYitlrTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
... |.. .      .|| |.|| ||||||.|||| ..||..  ||..|.|..||.|| ||  |||| 
flelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0051299 (Phosphotyrosine protein) phosphatases II 671-924 2.1e-82 272.1 In-house 19-272 (288) alignment 
Range on Protein: 671-924
Range on HMM: 19-272/288.0
DGESSLLEMEFQRLaTDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKS
 .  ..|..||..| .. .... . .| .  |. |||...|.||...||||| .   |||||||||||| |...|...|||||..|||||||||.||...
angltglleefeel.lsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnv

KIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLE---QPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYIt
..|||||||.|...| .. ||.. .| ..|.||..|.. ... || .|.... .|.   ... |.| .||....||. ||| |. .||.... |.. .  
rvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.

lRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
  .  |. |.|| ||||||.|||| ..||..  ||..|....||.|| ||  |||| 
.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 365-682 2.4e-82 271.3 In-house 5-313 (315) alignment 
Range on Protein: 365-682
Range on HMM: 5-313/315.0
NYQFPAHLAVMRmnDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGE
  |||| .   |      | |||  .|  . ... ||  . |  ||||.||||.|..||||  .  .  |||||||.. .. . . |||.|||   .. .
vaqfpafvnknr..htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvdd

FWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFtIMKggTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMI
|||||.... .|||||||.||   .||  |||    .   .| ..|.|..  . .. . | . ...   |.. | | ||.|| |||.||..  .|.| .|
fwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtr..kseesrtvtqfqftewPdkGvdkqtssllkli

RCVRAHHNRlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDK
. |.| ...   .. ...||||||||||| .. ||.....| . .. ||..  |. ||..| ..||||..| ||..|. | .    | ..  .|  ||. 
kevkadngk...kefsllvhcsaGvGrtGvvisidevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqd

LELIQEDGESSLLEMEFQ
|    .    | .  ||.
lhtsvdgsgrskmtkefe
subfamily_PTPN12_pd Subfamily PTPN12 396-647 2.9e-82 270.8 In-house 30-278 (290) alignment 
Range on Protein: 396-647
Range on HMM: 30-278/290.0
HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYW
...|... | | .|||| .|||||..||.||. . .||||||||.|. |  ....|||.|||...|. .||||.||.|   .||. .. |    ||..||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PTDVNERCTYGGVEVTLVECVPLA-NYTFRTFTIMKGgtsKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrlpPDTGPMIVHCSAGVGRTGT
|  ..|....| .|||| |   .  ... ||... .    |. |.|.|||.|||||||||. ..|.|..|. || ...    .  |..||||||||||||
peegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGt

FVVIDSMLQRILHGED--NVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIA
 ..|| . . . ..    ..|..  |. ||.||. .|||..|| ....|. | . 
iiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
0042113 (Phosphotyrosine protein) phosphatases II 399-644 1.6e-80 265.4 In-house 2-241 (245) alignment 
Range on Protein: 399-644
Range on HMM: 2-241/245.0
EVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTd
.||....|  |||| .|||||||||||| ......|||||||. ||.  ....||||||..||.. ||||.||... ||||.|.. |.. |||. |||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

vNERCTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRlpPDTGPMIVHCSAGVGRTGTFVVI
 .|  |||.. |||...  |..|| ||... .   ..  |||...|.. |||||||. . ..|.... || . ..  .. ||..|||||||||||||...
.gesltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaa

DSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
. ||... .   .|...  |  ||.||  .|||..|| |..||. |
ylmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 400-644 3.7e-80 264.2 In-house 4-240 (243) alignment 
Range on Protein: 400-644
Range on HMM: 4-240/243.0
VANYECNLAKNRYDNILPYDHTRVKLstvkwqEGSDYINASFLDGFmkPqQYIATQGPMAETIGE----FWRMVWEQNSATIVMVTKLQEKSTVKCDCYW
.|....|| |||| .||||||.||||      ||||||||.. ...  | ..||||||. ||. .    ||||.||... .|||.|.|.|.. .||. ||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PtdvNERcTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNR-----LPPDTGPMIVHCSAGVG
|   .|  |||...|||...  |..|| ||....  ....  |.|...|...|||||||. |...|.... ||.. ..       .. ||..||||||||
p...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTFVVIDSMLQRIlhgedNVDIYGHVTLLRNQRNF-MVQTEDQYFFIHEAINE
||||..... ||...     .||..  | |||.||.. .|||..|| |..||. |
RtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPRA_pd Subfamily PTPRA 658-927 6.1e-80 263.6 In-house 12-284 (330) alignment 
Range on Protein: 658-927
Range on HMM: 12-284/330.0
FPVHLDKLEL---IQEDGESSLLEMEFQRLATDRTEpHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPM
||. ..|||    |.   .. |.  ||. | . . .   .  |.|. || |||.|||.||...|| || .. .| |||||||.|| |...  ..|.||| 
fplpvekleeeirirsaddnklfreefnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

KNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQ---PEASYTLHHFQFLGWPERGVPVSA
..|||||||||||.||  |||||.|.|...|    || |  .  .|.|..|. .... .||  |.| . .| .    ..|  .. | | .||. |||. .
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

LPLLQMIQNVQELYitLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLSQ
  .|.....|..|    ....||.| ||.|||||| ||.|  ||||   |...|.|..|| || ||. ||||    
iGmlkllkkvkkln..qqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqy
0046845 (Phosphotyrosine protein) phosphatases II 677-924 6.5e-80 263.8 In-house 2-260 (284) alignment 
Range on Protein: 677-924
Range on HMM: 2-260/284.0
LEMEFQRLATDRTEPH-RFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRAT-EGSDYINASYIDSY-----RQQRAYLATQGPMKNTVEDFWRMIWEHK
|| ||..|    . ..  .  | .  |. |||...|.||...||||. .  . |.||||||||.| |     .......|||||..|||||||||.||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SKIIVMLTKLEEKQQECSFLYWSDLE-SRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITL
...|||||.|.|...|  . ||.. . . ..|..|..|...... || .| ... .|. .. |.|..||....||..||| |. .||.... |.||.  |
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RTTEPITVMCSSGVGRTGVFIALGIVLERYSVEG---MIDLFQTVKTLRIQRSAMVQTR
 . .|| |.|| ||||||.|||| ..||..  ||   ..|....|| || ||  |||| 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
subfamily_PTPN9_pd Subfamily PTPN9 398-644 4.6e-79 260.5 In-house 34-288 (297) alignment 
Range on Protein: 398-644
Range on HMM: 34-288/297.0
KEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPT
 ....  .|| |||| ..| ||.|||.|..|. .| ||||||.|.||. ... .||||||. .|. .||||||||.  .|||.|.. |.  .||  |||.
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

DVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAH----------HNRLPPDTGPMIVHCSA
. ...  .| ..|. || .   .|..|...| .  . .. |.|  | |..|||.|||.  .|.| ... || .          ... .|.  |..|||||
eeessaefgdlsvsnveveeeedykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

GVGRTGTFVVIDSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
|.||||||. .|  |.| |. ...||.   | |||.|| |..||..|| | . |. |
GiGrtGtfitldiclsr.leevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0047943 (Phosphotyrosine protein) phosphatases II 672-924 4.6e-79 261.0 In-house 9-258 (273) alignment 
Range on Protein: 672-924
Range on HMM: 9-258/273.0
GESSLLEMEFQRLaTDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLsfirATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSK
  ..||..||..| .. .... .  | .  || |||. .|.||...||||      .|||||||||.| |...|...|||||..|||||||||.||....
lgltllleefell.lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

IIVMLTKLEEKQQECSFLYWSDLE---SRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITL
.|||||.|.|...|  . ||.. .   | ..|..|..|.. ... || .|.... .|. .| |.| .||...|||. ||| |  .||..|. |.. . .|
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkaleal

RTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
.  .|. |.|| ||||||.|||| ..|...  ||..|....|| || ||  |||| 
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 371-666 7.6e-79 260.2 In-house 13-308 (325) alignment 
Range on Protein: 371-666
Range on HMM: 13-308/325.0
HLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMV-
|.   . .|.. |  ||| .| . |  |.||    | ||||. |....|..|| | | | .  |||||||.|  ..| . ..|.| |...||...||.| 
hvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvl

-WEqnSATIVMVTKLqEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTImKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVR
 |.  .. .|.. .| ..   .|  ||| .. .  |.||.|| |.    ...|  | . . |.    . | |.||.. .|.| ||...|....|... | 
dWr..csvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv.kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvk

AHHNRLPP---DTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKL
| ..|.      ..|..|||||||||||.|. . |.|..... | .|||.| |  ||..|  ||.| ||| .|.||. ||. .| |||    |  .|  |
avservtantkastpilvhcsaGvGrtGvfislysalakvie.esrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklssl

E
.
q
subfamily_PTPRB_pd Subfamily PTPRB 653-924 2.1e-78 258.3 In-house 7-271 (293) alignment 
Range on Protein: 653-924
Range on HMM: 7-271/293.0
VTSDQFPVHLDKLeliQEDGESSlLEMEFQRLATDRtEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQG
.. ..|  |..|.   ..| .   .  |...| .   . .  ..|...||. |||. ||.||...||||. .. ..|||||||.||. |...| ..||||
iklekfeehvkkm...kadsdlr.fseeyeelkavg.kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL-ESRQFGEITIELIKKKEEIDYLHRQFKIAHleqPEASYTLHHFQFLGWPERGVPVSA
|. .||.|||||.||.||.||||||.| || ..    || .  |. ..|.|...|....|  |.  |..|| .    ... ......|. ||. ||| ..
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPekt

LPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 .||.....|.|   .  ...||.| ||.||||||.||||  .|.. . | ..|.| .|  || .|  .||| 
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqte
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 649-924 3.7e-78 257.8 In-house 1-276 (298) alignment 
Range on Protein: 649-924
Range on HMM: 1-276/298.0
GVTDVTSDQFPVHLDKLELIQEDGESSLLEMEFQRLATDRT--EPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRA
| |.......  .| ||. .... . . ...||||| .     | .    | |. || |||. .|..... || |. . | | |||||||....|... |
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPeASYTLHHFQFLGWPERG
..|||.|...||||||||..|.... |||||.|||...     || | .....||||..| .|.|  |.  |..|... ..   . ......|  ||..|
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkg

VPVSALPLLQMIQNVQElYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
||  |  .|.....|.  . .    .|..| ||.||||.| |||.  ||||   | ..|.||.||.||..| ..|||.
vpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 674-924 2.2e-76 251.9 In-house 21-269 (305) alignment 
Range on Protein: 674-924
Range on HMM: 21-269/305.0
SSLLEMEFQRLATDrtePHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKII
.. ||.... |...   .. .   .|..|| |||...|.... .|..|.    .. ||||||||.|.|... .|...|||.||||.||||.|.| | . |
dkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLTKLEEKQQECSFLYWSDLESR--QFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITlRTT
|||||| | ....   || . ...  .|||...||  .|.  ||. |..||.  .. . | |. ..|.  ||. ||| .|  ||..|..||. .      
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkg

EPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 |..| || ||||||||||. | |||   |...|.|. .|.|| .|  |||| 
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl
DSPc_SM00195 677-924 3.2e-76 251.5 In-house 2-248 (263) alignment 
Range on Protein: 677-924
Range on HMM: 2-248/263.0
LEMEFQRLATDRTEPhRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVML
|..||..| . ...  .. .| |. || |||. ||.||. .||||. .  .||||||||.||. ......| |||||...||||||||.||.|.||||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TKLEEKQQECSFLYWSDL--ESRQFGEITIELIKKKEEI-DYLHRQFKIAHLEQpEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLrtTEP
|. ||...|    || .   .. .||.|...|......  ..  |.... . .. | .......|. .||..||| |. ..|.... |.. . |   ..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgp

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
| |.|| ||||||.|... |.|.. . | ..|.|..|| || ||  ||||.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
PTPc_SM00194 677-924 3.2e-76 251.5 In-house 2-248 (263) alignment 
Range on Protein: 677-924
Range on HMM: 2-248/263.0
LEMEFQRLATDRTEPhRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVML
|..||..| . ...  .. .| |. || |||. ||.||. .||||. .  .||||||||.||. ......| |||||...||||||||.||.|.||||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TKLEEKQQECSFLYWSDL--ESRQFGEITIELIKKKEEI-DYLHRQFKIAHLEQpEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLrtTEP
|. ||...|    || .   .. .||.|...|......  ..  |.... . .. | .......|. .||..||| |. ..|.... |.. . |   ..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgp

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
| |.|| ||||||.|... |.|.. . | ..|.|..|| || ||  ||||.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
0039614 (Phosphotyrosine protein) phosphatases II 667-924 4e-76 251.6 In-house 24-275 (297) alignment 
Range on Protein: 667-924
Range on HMM: 24-275/297.0
LIQEDGESSLLEMEFQRLATDRTEphrFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRAT-EGSDYINASYIDSYRQ-QRAYLATQGPMKNTVEDFWRM
|.    ...||..||..|     .   .  | . .|| |||...|.||...||||. .. . ..||||||||.| |.. .|...|||||...||||||||
llekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

IWEHKSKIIVMLTKLEEKQQeCSFLYWSDLESrQFGEITIELIKKKEEIDYLHRQFKIAHleqPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQEL
.||.....|||||||.|... . . ||.. .. ..|..|..|.| ... .| .|.... .    . |.|..|||..|||. ||| |.  ||.... |.| 
vweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrea

YITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
. .|.  .|. |.|| ||||||.|||. ..||..  || .|....||.|| ||. .||| 
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp
0036941 (Phosphotyrosine protein) phosphatases II 672-924 5.4e-76 251.0 In-house 10-263 (297) alignment 
Range on Protein: 672-924
Range on HMM: 10-263/297.0
GESSLLEMEFQRLaTDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLsfirATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSK
  ..||. ||..| ...  .  .  | .  |. |||. .|.||...||||      ||||||||||.| |...|...|||||..|||||||||.||....
lflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

IIVMLTKLEEKQQECSFLYWSDL--ESRQFGEITIELIKKKE--EIDYLHRQFKIAHLEQPeASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYIT
.|||||.|.|.. |  . ||..   || ..|..|..|.. ..  . ||  |.... ... .  |.|..||...|||. ||| |. .||..|. |.. .  
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkl

LRTTEPITVMCSSGVGRTGVFIALGIVLERYS---VEGMIDLFQTVKTLRIQRSAMVQTR
|.  .|. |.|| ||||.|.|||. ..|...     || .|....||.|| ||  .||| 
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
0040438 (Phosphotyrosine protein) phosphatases II 675-924 6.3e-76 251.0 In-house 18-262 (317) alignment 
Range on Protein: 675-924
Range on HMM: 18-262/317.0
SLLEMEFQRLATDRTEphRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
 .|. ||..| .   .   .  | . .||.|||...|.||...||||| .   ..||||||||.| ....|...|||||..|||||||||.||.....||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLeQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYItlRTTEPI
|||.|||...| .. ||.. |. ..|..|..|.. .|. .. .|.... .| . . | |..||...|||. ||| |  .||.... |.| .   .  .|.
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpv

TVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 |.|| ||||||.|||. ..||.   || .|....||.|| ||. .||| 
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp
0045450 (Phosphotyrosine protein) phosphatases II 661-924 4e-75 248.7 In-house 13-290 (307) alignment 
Range on Protein: 661-924
Range on HMM: 13-290/307.0
HLDKLELIQEDGESSLLEMEFQRLATDRTE-PHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRAT-EGSDYINASYI--------DSYRQQRAYLAT
.|..| |..     ..|. ||..|    .. .. . .| . .|| |||...|.||...||||| .  . |.||||||||.        |.|...|...||
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL-ESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPV
|||...||||||||.||.....|||||.|.|. .|  . ||.|  |. ..|..|..|...... .| .|.... .|.. . | |..||...|||. ||| 
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

SALPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGM---IDLFQTVKTLRIQRSAMVQTR
|  .||..|. |.. . .|.  .|. |.|| ||||||.|||. ..|..   ||.   .||...||.|| ||. .||. 
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 381-644 4.6e-75 247.2 In-house 5-266 (274) alignment 
Range on Protein: 381-644
Range on HMM: 5-266/274.0
QRFMEEFGTIPMNPgHPKEvANYECNLAKNRYDNILPYDHTRVKLSTVKW-QEGSDYINASFLDGFM-KPQQYIATQGPMAETIGEFWRMVWEQNSATIV
. . .||  .|.|  ...|  .   .  |||| .||| ...|| |.. .  .| |.|||| .. |.  . . |.|||||...|. .||||......  ||
kdlekeflelPlnf.dqee.ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MVTKLQEKSTVKCDCYWPTDVNE--RCTYGGVEVTLVECVPLANYTFRTFTIMKGGTskdLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLPP
|.|||.|.   ||  |.|.. .     .||.||.. .. |   .|. |.... .       |.|  . .|.|||| .|. ....|.... |.  ...   
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeena

DTGPMIVHCSAGVGRTGTFVVIDSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
 ..|..||||||.|||| |. |.  ... |. |  ||. . |. || .|  ||||..|| .||.|. .
klapvvvhCsaGiGrtGcfiaisiavrq.lreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
0043336 (Phosphotyrosine protein) phosphatases II 674-924 3.5e-74 245.1 In-house 19-263 (278) alignment 
Range on Protein: 674-924
Range on HMM: 19-263/278.0
SSLLEMEFQRLATDRTepHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKII
 .||. ||..| .  .    .  | .  || |||...|.||...||||| .   ..||||||||.| |...|...|||||...||||||||.||.....|
ktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

VMLTKLEEKQQECSFLYWSdLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEAsYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYItlRTTEP
||||.|.|.... .. ||.  .| ..|..|..|.| ... || .|.... .|  .|  .| .|...||||. ||| |  .||.... |.| .      .|
vmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale..dsngp

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
. |.|| ||||||.|||| ..||..  || .||...||.|| ||  .||| 
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp
subfamily_PTPN13_pd Subfamily PTPN13 379-645 2.3e-73 241.8 In-house 9-268 (273) alignment 
Range on Protein: 379-645
Range on HMM: 9-268/273.0
DNQRFMEEFGTI-PMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLStvkwQEGSdYINASFLDGFMKP--QQYIATQGPMAETIGEFWRMVWEQNSA
|.|   ||| ..  . |    ||.. . | .|||| |.||||.|||||.    .||. |||||..   .     .|||.|||. ||. .||.|||||.. 
dqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkae

TIVMVTKLQEKSTVKCDCYWPTDVNERCTYGG-VEVTLVECVPLANYTFRTFTIMKgGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrl
 |.|||. .||  |||. |||   |.. .  . .||.|.. . | ... |.... .   |.. ||| ...|..|||||||  ....| ... ||  ..  
viamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkd.sesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..

ppDTGPMIVHCSAGVGRTGTFVVIDSMLQrILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
  |.||..||||||.||.||...|| .|. ... . ..|.   |  ||.||. .|||.||| |...|| |.
..dagPivvhcsaGiGrsGtlitidvvlg.lierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 367-657 2.4e-73 241.9 In-house 14-295 (297) alignment 
Range on Protein: 367-657
Range on HMM: 14-295/297.0
QFPAHlaVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKpqQYIATQGPMAETIGEFW
.|..   | .  . . | |||  .|    .|. ||.   |. |.|| ||||||  ||||  |  .  |||.||||. |. .  ..|.|| || .|. .||
dfatl..vqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfW

RMVWEQNSATIVMVTKLQEKSTvKCDCYWPTDVneRCTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPE--FPTSMLSMI
.||.... .||||.....|.   ||  ||. .     |.| | |.|        .  |.... ||  .|  | |.|..|. |||. |..    .|.| .|
amvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkg.kakarrvvkqyqfveWPdkaverkdsassllkli

RCVRAHHNRLppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQ
  || ...      ||..|||.||||||| .. |||.. .. . |..|||.| |. ||..| ..|||..|| |...|..||. .  |.. .. 
sevrkdfsqn..aegPllvhclaGvGrtgvlltidsvvaeakr.ekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 676-924 4.1e-73 240.9 In-house 22-265 (288) alignment 
Range on Protein: 676-924
Range on HMM: 22-265/288.0
LLEMEFQRL-ATDRTEPHRfaSATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
 .. |.. | | ..|. .    . . ||. |||. ||.||...||||     ..|.|||||||||.......|.|||||. .||.|||....|.|.. ||
gfseeynsLaalektksvt..agrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstiv

MLTKLEEKQQECSFLYWSDLES-RQFGEITIELIKKKEEIDYLHRQFKIAhleQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLrtTEP
|||.| |....    || | .  ...|..|..|...||. |...|.. .    . .  ......|.|.||. ||| |. |||.....|.        |.|
mltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgp

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
|.| || ||||||.||||  ....   | .||.. ||. || ||  .||| 
iivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 671-930 6.8e-71 234.2 In-house 30-282 (319) alignment 
Range on Protein: 671-930
Range on HMM: 30-282/319.0
DGESSLLEMEFQRLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKS
| . . ||.||.|..   ..    . |  . || |||..||.... |.|||  .   |.|||||||... |...  |.|.|||..||..||||||||...
dddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

KIIVMLTkleekQQECSfLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRT
  ||.||     .. ||  ||      . ..  ...   .|  .|  |......  . .    .. | |||||. ||| .. .|......|. |    . 
stivllt.....kdkcs.qywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh

TEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKI
 ..| | ||.|||||||.|.| ..|.|   | ..|....|. || ||. .||  | | |.
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqd.lvqykf
Y_phosphatase Protein-tyrosine phosphatase 702-923 7.4e-71 233.6 Pfam-A 1-222 (235) alignment 
Range on Protein: 702-923
Range on HMM: 1-222/235.0
NKGKNRFVNIMPYEYNRVKLsfiRATEG-SDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWS--DLESRQ
|| |||. .|.||. .||||   . .|| ||||||.|...|.......|||||.|.|.||||||.|..|.|.|||||.||||..|    ||.  . || .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGEITIELI-KKK-EEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYitLRTTEPITVMCSSGVGRTGVFIALGIVLE
.|.|..||  |.| .| .|  |.... . ...... ....... .||..||| |. .||..|..|..      ...|..|.|| ||||||.|.|| |.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RYSVEGMIDLFQTVKTLRIQRSAMVQT
. . |. .|..|.||.|| ||  |||.
qleaeeevdvlqivkelRkqRpgmvqs
Y_phosphatase Protein-tyrosine phosphatase 702-923 7.4e-71 233.6 In-house 1-222 (235) alignment 
Range on Protein: 702-923
Range on HMM: 1-222/235.0
NKGKNRFVNIMPYEYNRVKLsfiRATEG-SDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWS--DLESRQ
|| |||. .|.||. .||||   . .|| ||||||.|...|.......|||||.|.|.||||||.|..|.|.|||||.||||..|    ||.  . || .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGEITIELI-KKK-EEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYitLRTTEPITVMCSSGVGRTGVFIALGIVLE
.|.|..||  |.| .| .|  |.... . ...... ....... .||..||| |. .||..|..|..      ...|..|.|| ||||||.|.|| |.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RYSVEGMIDLFQTVKTLRIQRSAMVQT
. . |. .|..|.||.|| ||  |||.
qleaeeevdvlqivkelRkqRpgmvqs
subfamily_PTPRG_pd Subfamily PTPRG 676-924 1.5e-69 229.7 In-house 20-273 (563) alignment 
Range on Protein: 676-924
Range on HMM: 20-273/563.0
LLEMEFQRLATDRTEP-HRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGS-DYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKII
 .. ||. | .  ..      .. |. || ||| .||..|.  ||||| .  .... |||||.||| |....|..|||||.|.|..||||||||....||
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaii

VMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQP-----EASYTLHHFQFLGWPERGVPVSALPLLQMIQNVqeLYITL
||.|.|.|....  . ||   || ..|.... ||...  . |  |...| .|.       .   .  ....  ||. ||| ..|| |....     . . 
vmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saank

RTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
... ||.| ||.||||||..|.|  .|..   | ....|...|..| ||  .|||.
aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqte
subfamily_Ptp69D_pd Subfamily Ptp69D 675-927 2.1e-69 229.0 In-house 22-274 (307) alignment 
Range on Protein: 675-927
Range on HMM: 22-274/307.0
SLLEMEFQRLATDrTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
 .|. |...| .  . ..    . |. |. |||. .|.... .||||. |  .| |||||||.| .|.... ..| |.|. .|..||||||.| ....||
fglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLE----QPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLrt
||..|.||...    ||.. .  |.|.| ..|.....  || .|...... .    . |.|  .  ....||..  || .|  ||..|..|.||| .   
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..

TEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQtRLSQ
  ||.| || ||||.|.|.|| ..|..   |  .|.|.||| || ||. .|| .| |
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvq.sleq
subfamily_PTPN6_pd Subfamily PTPN6 661-931 3.3e-69 228.2 In-house 12-290 (306) alignment 
Range on Protein: 661-931
Range on HMM: 12-290/306.0
HLDKLELIQEDGESSLLEMEFQRLATD-RTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfIRATEGSDYINASYID--SYRQQRAYLATQGPMKNT
. ..||  .|. | . .| ||..| ..  .. .    ..|. || |||. ||.|.. .||.|.    . |||||||.||.  .  ....|.|||| ...|
rvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclett

VEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLE-SRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQ
|.|||||.|. .|..|||.||  |. .|    || | | ....|.|... ...|.  ||  |...... .. . . ......|  ||. ||| .   .|.
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLd

MIQNVQELYITLR--TTEPITVMCSSGVGRTGVFIALGIVLERYSVEG---MIDLFQTVKTLRIQRSAMVQTRLSQKKIV
....|.. . .|.  .. || | ||.|.|||| || . |.|.  . .|    ||. ..||..| ||| .|||    | . 
fledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvy
subfamily_PTPN3_pd Subfamily PTPN3 393-645 5.1e-69 227.3 In-house 28-274 (280) alignment 
Range on Protein: 393-645
Range on HMM: 28-274/280.0
NPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKwqeGsDYINASFLD----GFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKST
.||   ..|.   ||.|||| .|||||.|||||.  .     |||||....    .    ..|||||||.|.|  .||.|||||.| .|||.| | |.  
kpglaisaarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr

VKCDCYWPTdVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGgTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRlppDTGPMIVHCSAG
|||  |||.  .....||. .|.. ..    .| .| .....  ..|. |.. |. ..||||||||. ....|.... ||. ..    .. |..||||||
vkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdk.etkeerkilqlqylaWpdhgvPddsadflefvervrklrsg...keePvvvhCsaG

VGRTGTFVVIDSMLQrILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
.|||| .....  |. ..  ...| .   |  .|.||  .|||..|| |. ||| ..
igrtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 679-930 5.1e-69 227.9 In-house 2-246 (284) alignment 
Range on Protein: 679-930
Range on HMM: 2-246/284.0
MEFQRLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTk
.||.|..   ..    . |  . || |||...|.... |.|||  .   |.|||||||.|  |...  |.|||||..||..||||||||...  ||.|| 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

leekQQECSfLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTTEPITVMC
    .. ||  ||      . ..  ...   .|  .|  |......  . .   ... | |||||. ||| .. .|......|. |    .  ..| | |
....kdkcs.qywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKI
|.|||||||.|.| ..|.|   | ..|....|. || ||. .||  | | |.
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqd.lvqykf
subfamily_PTPRK_pd Subfamily PTPRK 694-924 6.8e-69 227.1 In-house 35-263 (314) alignment 
Range on Protein: 694-924
Range on HMM: 35-263/314.0
FASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSD
. .| |. |. |||. .|..|.  ||.|  |     ||||||..||||.. .|...||||...||.||||.......  |||||.| |...     || .
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

lESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEAS-YTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITlrTTEPITVMCSSGVGRTGVFIALG
 .....|.| .||.. . . ....| |.. .|...     ....|||||||. .|||||  ||.....|..      .  .| | ||.| ||||.|||. 
.dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaid

IVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
|||.    ||..|.|..||||| ... ||.| 
ivldmieregvvdvfnavktlrsrkvnmvete
0040439 (Phosphotyrosine protein) phosphatases II 696-923 8.8e-69 227.1 In-house 5-231 (249) alignment 
Range on Protein: 696-923
Range on HMM: 5-231/249.0
SATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLE
 | . .|| |||...|.||...||||| ..  ..|||||||||| |...|...|||||...||||||||.||.....|||||.|.|...|  . ||.. .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

SRQFGEITIELIKKKEEIDYLHRQFKIAHLeQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVL
| ..|..|..|.. ... || .|.... .| .   |.| .|.|...||. ||| |  .||..|. |.. . .|.. .|. |.|| ||||||.|||. ..|
sleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

ERYSVEGMIDLFQTVKTLRIQRSAMVQT
|..  |. .||...||.|| ||. .||.
eqlekelgvdleeavkllrsqRpgavqn
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 390-645 1e-68 226.3 In-house 4-263 (270) alignment 
Range on Protein: 390-645
Range on HMM: 4-263/270.0
IPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFM-KPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKST
.. .  ..... ..  . . ||| .|||  .|||.|.... .. . |||| .. ||  ....|||..||.. |. .||||.||... .|||.|.|.|| .
ldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgr

VKCDCYWPTDVNE--RCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLRevrQFHFTAWPDHGVPEFPT------SMLSMIRCVRAHHNRLPPDTgP
 ||..|||....|  ....| ..|. .. .    | ..  .. . |... |     |....|||||||. .       ..|.|.| ||.....|   . |
kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv...HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.P

MIVHCSAGVGRTGTFVVIDSMLqRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
..||||||||||||....| .. |.|. . .||.   .. ||..|  .||. .|| |...|. | 
llvHcsaGvgRtGtlialDiav.rlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_PTPN1_pd Subfamily PTPN1 396-650 4.5e-68 224.1 In-house 22-275 (290) alignment 
Range on Protein: 396-650
Range on HMM: 22-275/290.0
HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWqegsDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYW
.| ..|. . | ..||| .. ||||.|.||   .     ||||||...     ..|| ||||...|.. ||.|||||.| ..||. |. ||...||  ||
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PTDVNER-CTYG--GVEVTLVECVPLANYTFRTFTIMKgGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHhNRLPPDTGPMIVHCSAGVGRT
|.. .|.  ..    ..|.|..     .|| |.. . .  .... ||. .||.|.||| |||| |...|...  ||     | .| || ..|||||.||.
Pqgeeekellledtklkvkliseerksyytvrllelen.lktqetreilhfhyttwpdfgvpespaaflkflfkvres.GslssdvGpavihcsaGiGrs

GTFVVIDSMLQRILHGED--NVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGV
|||...|..| .| . .|  .|||  ..  ||..|  ..|| ||  | . || | . .  
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvik
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 406-643 6.3e-68 223.5 In-house 3-236 (237) alignment 
Range on Protein: 406-643
Range on HMM: 3-236/237.0
NLAKNRYDNILPYDHTRVKLSTVKwqEGSDYINASFLDGFM-KPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPtDVNERCT
| .|||| ||  |||.|| |       |||||||..|.||   |..|||.|||.  .  .||.|||... . |||.| | |.  .||  ||| . ..  .
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaa

YGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAhHNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQR
|| . |.|     ...|| |.....| .| |..| . |..||.|||.|||.  ...| . . .   ...  ...|| |.|||||||||| |.|||.||..
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniin.rsphvsesgpwiihcsagvgrtgiflvidamlrq

IlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
  . .  |||| .|  . ..| ...||.||| |||..| 
a.kekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 697-924 8.9e-68 223.2 In-house 4-228 (250) alignment 
Range on Protein: 697-924
Range on HMM: 4-228/250.0
ATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSfLYWSDLES
| |  || |||. .|....  || |   .. . |||||||....|....|..|||||...|.||||||..|.||. |||||.|.|......  ||   ..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyh.qywPveka

RQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLrTTEPITVMCSSGVGRTGVFIALGIVLE
...|..|..| .|.|  || .|..|... .. . . .. ...|. ||..|||  |   |.....||        . |. | ||.||||.| |||.  |||
ekyGdvtvsllskeefadytkrklklskakkad.erivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.gnaPvivqCsaGvgrsGafiaidavle

RYSVEGMIDLFQTVKTLRIQRSAMVQTR
|   | ..|.|. .|.||..|  .|...
rlkkekvvdvfkvikvlrkdrphavesl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 363-673 4.2e-67 221.2 In-house 4-262 (392) alignment 
Range on Protein: 363-673
Range on HMM: 4-262/392.0
IHNYQFPAHLAVMRmnDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETI
|   |||| .   |   .  |.|||  .|  . .|. ||. | || ||||.|||||| .||||  .     |||.|||....|   . |||.||| | ..
ipvaqfpafveknr..hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasl

GEFWRMVWEQNSATIVMVTKLQEKStvkcdcywptdvnerctyggvevtlvecvplanytfrtftimkggTSKDLREVRQFHFTAWPDHGVPEFPTSMLS
 .|||||...| .||.|||||.|                                                 .| | | ||||| |||..||.. .|.| 
ddfwrmvfqenvttiamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllk

MIRCVRAHHNRLppdTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHL
.|. |.|.. .    | |.|.||||||||||  . |||.. .  .    ||..  || .|..| .||||..|| ||. |. | .    | .   .|  ||
fikevkadfGqy...thpliihcsagvgrtgvvisidsvvahakk.trmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhl

DKLELIqEDGE
..|.    ||.
qdlsts.sdGd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 367-659 8.6e-67 220.5 In-house 6-292 (439) alignment 
Range on Protein: 367-659
Range on HMM: 6-292/439.0
QFPAHLAVMRMNDNQRFMEEFGTIPM-NPG--HPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIG
.|  |.  .  |... | |.| .|   .|       .|  | . .|||| .. ..||||| |  .     | |||| ...|. ... |||||||  ||  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

EFWRMVWEQNSATIVMVTKLQEKSTvkcdcYWPTDvnERCTYGGVEVTLVECVPLANYTFRTFTIM-KGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLS
.|||.|.|....||||.|.| |        |||.|  . . || . |     . | ||. | | .. .  |..  | | |||..||||. ||   . .| 
dfwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

MIRCVRAHHNRlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRiLHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFP
..|.. .  ..   ..||..|||||||||||| . .|  |.. |. |..||| | |..||.||. |||.  || ||..|. | |  | . || |.| 
flrainsandk..eeygpvvvhcsagvGrtGtiialdialeq.lklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefk
0045098 (Phosphotyrosine protein) phosphatases II 691-924 1.9e-66 219.6 In-house 22-258 (278) alignment 
Range on Protein: 691-924
Range on HMM: 22-258/278.0
PHRFASATKNVNKGKNRFVNIMPYEYNRVKlsfirategsDYINASYIDSYrqQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLY
| ..  | .  |. |||...|.||...|||          |||||||||.|  .....|||||...||.|||||.||.....|||||.|.|...|  . |
pseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHL---EQPEASYTLHHFQFLGWPERGVPVSA--LPLLQMIQNVQELYI-----------TLRTTEPI
| . .| ..|..|..|.. ..  || .| ... .|   ..   |....|...|.||. ||| .    ..|.... ..| .            .|   .|.
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

TVMCSSGVGRTGVFIALGIVLERYsvEGMIDLFQTVKTLRIQRSA-MVQTR
 | || ||||||...|. ..||..  || .||...||.|| ||   .||. 
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnl
0042113 (Phosphotyrosine protein) phosphatases II 697-923 4.3e-66 218.1 In-house 4-228 (245) alignment 
Range on Protein: 697-923
Range on HMM: 4-228/245.0
ATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLES
| . .|| |||...|.||...||||| .   ..||||||||.| ||. . ..|||||...||||||||.||.....|||||..||.... .. ||.. ||
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

RQFGEITIELIKKKEEIDYLHRQFKIAHlEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLE
 ..|..|..|.. . . || .|.... . ..   | . .|...|.||. ||| .   ||.... |.. .      .|. |.|| ||||||.|||. ..||
ltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmle

RYSVEGMIDLFQTVKTLRIQRSAMVQT
..  |. ..|...|| || ||. .|||
qlekelgvsleeavkelrsqRpgavqt
subfamily_PTPN9_pd Subfamily PTPN9 692-924 1.2e-65 216.4 In-house 32-276 (297) alignment 
Range on Protein: 692-924
Range on HMM: 32-276/297.0
HRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
 .|  . ...|  |||. ... |.  ||.|. .  .| ||||||...| |.|..|..|||||.|.||.|||||.||..  .||| |...|...     ||
GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyW

S--DLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYIT------L-----RTTEPITVMC
   . .| .||..... .. .|| || .|...| . .. | | .. |||||.||. ||| ||  ||.....|.|   .             .  || | |
pleeessaefgdlsvsnveveeeedykvrvleiknvktee.srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhc

SSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
|.|.|||| ||.| | |.|   .|..|...|||.|| ||. ..|| 
saGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtp
subfamily_PTPN12_pd Subfamily PTPN12 682-924 1.3e-65 216.1 In-house 22-263 (290) alignment 
Range on Protein: 682-924
Range on HMM: 22-263/290.0
QRLATDRTepHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEE
... ....  .. ....|..|. |||. .|.||...||.|| |. .||||||||..|    .. .|.|.|||. .|..||||||||.. .|.||. .. |
ekykaekv..ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCreve

KQQECSFLYWSDL--ESRQFGEITIELIKKKEEI-DYLHRQFKIAHLeqpEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYItlRTTEPITVMC
 ..     ||..   |. .|||....|...|    |.| |..|. .    ..| ... |..  ||..||| || .||..|..|.||    .  .|. | |
lgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhC

SSGVGRTGVFIALGIVLERYSVE---GMIDLFQTVKTLRIQRSAMVQTR
|.||||||. ||. .| |    |     .|.|. | .|| ||.|.|||.
saGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtk
subfamily_PTPN23_pd Subfamily PTPN23 398-644 1.5e-65 215.9 In-house 35-278 (288) alignment 
Range on Protein: 398-644
Range on HMM: 35-278/288.0
KEVANYECNLAKNRYDNILPYDHTRVKLStvkwQEGSDYINASFLDGFMK-PQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWP
. .|  ...  |||. .||||||.||||     ..  |||||||. .      ..||||.|...|...||.||.|| | .|||... .|.   |.| |||
rsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

TDVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSkDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRA-HHNRLPPDTGPMIVHCSAGVGRTGTF
.| .|  ..| ..||| .   . ..  |....   ...   ..|.  ..|.||..|||. | ..| ..  |.. ....  .   |..|||||||||||.|
edkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf

VVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
 .. . .. . .|.  .||   |  ||.|| ||||...|. |  ||. |
alvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_CG7180_pd Subfamily CG7180 406-651 1.8e-65 215.5 In-house 42-295 (296) alignment 
Range on Protein: 406-651
Range on HMM: 42-295/296.0
NLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTvKCDCYWPTDVneRCTY
|. |||. ...|||..|| |.... .| ||||||.. |.|.|...|| |..|. ||..||||.|..... ..|..||  . .  ..  ||| .   .  |
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqy

GGVEVTLVECVPLANYTFRTFTIMKG---------GTSKDLREVRQFHFTAWPD-HGVPEFPTSMLSMIRCVRAHHNRL--PPDTGPMIVHCSAGVGRTG
| ..| .||   .|| . ||| ..|          . . . | |..|..| |.  . ||   .... ..| ||   ..    |..||..|..| |..|.|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

TFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVT
 .. ||  |. . . |..||... |  ||..|. .|.. ..| .| . ..||. |...
vylaidanlelv.ekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 378-653 5.9e-65 214.1 In-house 17-285 (287) alignment 
Range on Protein: 378-653
Range on HMM: 17-285/287.0
NDNQRFMEEFGTIPMNPGHPKEVAN--YECNLAKNRYDNILPYDHTRVKLStvkwQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSA
. |. |.. | ..     ...||     . |  |||. .||..|  || |     .|  |||||.|.||. . ...|....||..|. .||......|  
kgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvt

TIVMVTKLQEKSTVKCDCYWPTDVNerCTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHG-VPEFPTSMLSMIRCVRAHHNRl
.|||.....|. . .|  |||.. .   ..|  ...|..    |.|. |.. . . . ..| ..|.|...|.|...| |.|. |..| . . ..... | 
aivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkr.

ppDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDV
    ....||||..|||...|. ..  ...  . |  .|..  .   | |.  .||| .|| || ... | . .. | .
..gntsivvhCsdtvGrsamfcaaattinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 403-645 1.1e-64 212.8 In-house 4-239 (239) alignment 
Range on Protein: 403-645
Range on HMM: 4-239/239.0
YECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGF-MKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNE
   | ||||| ||. |||.|| |  .  .  |||||||.|  .   |. |||||| .. . |.||||.|..  . |||.| | |    ||  |||   ..
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

RCtygGVEVTLVECVPLANYTFRTFTIMKGGTSKDlREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRahHNRLpPDTGPMIVHCSAGVGRTGTFVVIDSM
 |    . ||| .   .|.|  ||| . . | ... | | |.||| |||.|||.. |..| . | .   .. | | . | ..||||||||||.|.|||.|
yc...nlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkit..kdsl.pgarpwvihcsagvgrtgaflvidam

LQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
|..  . .  |||. .|  .|..| .|||| .|| ||| |. ||
lrqa.kkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 400-643 1.7e-64 212.3 In-house 2-238 (239) alignment 
Range on Protein: 400-643
Range on HMM: 2-238/239.0
VANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGF-MKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTD
 |.   | ||||| ||. |||.|| |  .  .  |||||||.|  .   |. |||||| .. . |.||||.|..  . |||.| | |    ||  |||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

VNERCtygGVEVTLVECVPLANYTFRTFTIMKGGTSKDlREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRahHNRLpPDTGPMIVHCSAGVGRTGTFVVI
 .. |    . ||| .   .|.|  ||| . . | ... | | |.||| |||.|||.. |..| . | .   .. | | . | ..||||||||||.|.||
tskyc...nlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkit..kdsl.pgarpwvihcsagvgrtgaflvi

DSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
|.||..  . .  |||. .|  .|..| .|||| .|| ||| |. 
damlrqa.kkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 681-930 3.3e-64 211.6 In-house 26-270 (287) alignment 
Range on Protein: 681-930
Range on HMM: 26-270/287.0
FQRLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLE
|. |     ...    .  . || |||. .|.... .|| |      |  |||||..||.|....|......|| ||. .||..|.... ..||||....
ftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqek

EKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERG-VPVSALPLLQMIQNVQELYitLRTTEPITVMCS
|...|  . ||.. .|  .|| .|||.... . .|. |.... . .. ..  ... .|.  |...| |.  .  ||.. . ... .   |.  .| | ||
endeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqr..krgntsivvhCs

SGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLSQKKI
 .|||...|.|  . ...   || ||.|| .|  |||.  .|||    | |
dtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfi
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 367-646 9.3e-64 210.1 In-house 6-283 (290) alignment 
Range on Protein: 367-646
Range on HMM: 6-283/290.0
QFPAHLAVMRMNDNQRFMEEFGTIPM-NPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEG--SDYINASFLDGFMKPQQYIATQGPMAETIG
.|  ..|  ... |..| ..|...   .  |  .|.. . |  .||..||..||  |. |  .  ..    .||||....|. . .||||||||. .|. 
kfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlv

EFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERctYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHG-VPEFPTSMLS
.||...|..... |||.|. .|. .|||  |||.  ...  || ....|..   | .|. |.. . .  .... ..| |...|.|...| |..  |..|.
dFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

MIRCVRAHHNRLppdTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
. . .. .. |     ....||||..|||...|....  ...  . |  .|..  .  .| |.  .|||..|| .|.. . ...
ieemyktqrkrg...ntsivvHCSdtvgrsavfcaaattinkc.ktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 673-924 5.1e-63 207.8 In-house 17-263 (315) alignment 
Range on Protein: 673-924
Range on HMM: 17-263/315.0
ESSLLEMEFQRLATDRTEPHRfaSATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKI
 ..|.  ||. |    . ..|  .| ...|  |||. ||.|.. .||||  |  .  ||||||||| |. ...||.|.||| | .|.|||||....|   
htalfseefhdlpdPdiyrqr..varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtt

IVMLTKLEEKQQ-ECSfLYWSD--LESRQFGEITIELIKKKEEIDYLHRQFkiaHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELyiTLR
|||.||..|  . .|   || |   .| .||.| .||.. .   |  .|..    . . |.| |.  ||| .||..||.  .  ||..|..|.      .
ivmvtkkqegdkikcr.qywPdrkadsvefGsikvellsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngk

TTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 . .. | ||.|||||||.|..  |...   . ..|.|..||.|| .|  .|||.
kefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqte
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 678-938 5.4e-63 207.6 In-house 23-282 (290) alignment 
Range on Protein: 678-938
Range on HMM: 23-282/290.0
EMEFQRLATdRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEG--SDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVM
. .|..| .   ..|    .. . || .||| ||..|. ||. |  |   .    .||||.||. |.....|.|||||..||. |||..||..|. ||||
rnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivm

LTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERG-VPVSALPLLQMIQNVQELYitLRTTEPI
||.  |....    ||.| .....||..|.|.. ..  .| .|.... . .. .|. .....|.  |.. | |.  .  ||.. . ..  .   |. ..|
ltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqr..krgntsi

TVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRlSQKKIVLSLKMTY
 | || .|||..||.|. . ...   || ||.|| .|..|||.  .|||   | ... .. .||
vvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtv.qqyqgifqivlty
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 666-925 5.5e-63 207.8 In-house 17-271 (297) alignment 
Range on Protein: 666-925
Range on HMM: 17-271/297.0
ELIQEDGESSLLEMEFQRLATDRTEPHrfASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQqrAYLATQGPMKNTVEDFWRMI
 |.|.. .... . ||. | .  . |     | |.||  |.|. ||.||. .||||  .     |||.|||.. ....   ...|| |||.||.|||.|.
tlvqknrhtdvfseeflclpeaniqpq..tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamv

WEHKSKIIVMLTKLEEKQQECSfLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHlEQPEASYTLHHFQFLGWPERGVPV--SALPLLQMIQNVQE
.... ..||||....|....|   ||||  . .||.....|   .|   ...|...... ... |   .. .||. ||.. |.   ||  ||..|..|..
ldeqvstivmlnddnerdkkca.ryWsdkgvttfGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrk

LYITLRTTePITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
 . .   . |. | |..|||||||....  |. .   |  .|.|..|| || .|  .|||. 
dfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtke
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 672-924 6.4e-63 207.6 In-house 15-262 (515) alignment 
Range on Protein: 672-924
Range on HMM: 15-262/515.0
GESSLLEMEFQRLATDRTEPHRFasATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSK
.  .|.  ||. |      |     | ...|  |||. ||.||. .||||  |     |||.||||| |.  ..||.|.||| | .|.||||......  
rhttlfseefhdlpgpniypqtv..aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvt

IIVMLTKLEEKQQECSFLYWSD--LESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQpeaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELyiTLR
 |.|.|||.|  .     || |   .| .||.| .||.  .   . . |.... . ..   | |.  |.| .||..|||  .  ||..|..|.    . .
tiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkad..hgq

TTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 | |. . ||.|||||||.|..  |. .     |.|.|..|. .| .|  .|||.
ythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtq
subfamily_PTPRN_pd Subfamily PTPRN 397-646 3.7e-62 204.7 In-house 47-292 (297) alignment 
Range on Protein: 397-646
Range on HMM: 47-292/297.0
PKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFL-DGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYW
 ||||. | |. |||. ..|||||.||||..   .| |||||||.. |   .   |||||||.|.|. .||.||||| .. ||..|.|.|... .|. ||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PTDVNErcTYGGVEVTLV-ECVPLANYTFRTFTImKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRlppDTGPMIVHCSAGVGRTGT
| . .|  .|.  || || | .   .|  |.| . |   ... | | |||| .||..|||  . |.| . | |   .      . |..||||.|.||||.
pdeGse..vyhiyevhlvsehiwcddylvrsfyl.knlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG...rscpivvhcsdGaGrtGv

FVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAI
...|| .|.|.|.|  ..||   .  ||.||. .|.|.||. |.  |. | .
yilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
0037934 (Phosphotyrosine protein) phosphatases II 696-924 6e-62 204.7 In-house 4-228 (243) alignment 
Range on Protein: 696-924
Range on HMM: 4-228/243.0
SATKNVNKGKNRFVNIMPYEYNRVKLsfiratEGSDYINASYIDSYRQqraYLATQGPMKNTVED----FWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
 | . .|. |||. .|.||...||||      ||||||||..|. ...   . |||||...||||    ||||.||.....|||||.|.|...|  . ||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

SdlESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYIT------LRTTEPITVMCSSGVGRT
.  .. ..|..|..|.. ..  || .| ... .|. .. ... .|...|.||. ||| |  .||.... |.| .        | . .|. |.|| |||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVFIALGIVLERYsveGmIDLFQTVKTLRIQRSA-MVQTR
|..||. ..|...   | .||...||.|| ||.  .|||.
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtp
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 676-928 1.6e-61 202.9 In-house 16-266 (281) alignment 
Range on Protein: 676-928
Range on HMM: 16-266/281.0
LLEMEFQRLAT-DRTEPHRfASaTKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
 . .|.. ||  .. .. . || ... |. |||..||. |.  |||..   ... .|||||.....|.....|.|||||. .....||.|.||.| ..||
Gfieeyeklaaigvdntat.as.kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLTKLEEKQQECSFLYWSDLE-SRQFGEITIELIKKKEEIDYLHRQFKIaHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYiTLRTTEP
|.|.  |. .     || | . . ..|..|.. ....|.  |..|.||. . |. | . ........ ||. ||| ..  ||.  ..|..|  . .|  |
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresge.treveqlaytaWPdhGvPattkellefrkevlklt.ekktkap

ITVMCSSGVGRTGVFIALGIVLERYSV-EGMIDLFQTVKTLRIQRSAMVQTRLSQK
. . ||.||||||..|||  .... .  . ..|. ..|. || .|  |||| .  .
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqye
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 680-924 9.3e-61 200.7 In-house 28-274 (325) alignment 
Range on Protein: 680-924
Range on HMM: 28-274/325.0
EFQRLATDrtEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKL
||. | .|  ..  .  |.|  || |||| |..... .|| |   .    ||||||||. .....  .||.| |. .|..|.||.. . .. ..|.| .|
efgllpsd..dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlnel

EEKQQECSfLYWSDL--ESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEAsYTLHHFQFLGWPERGV---PVSALPLLQMIQNVQELYIT-LRTTEP
......|.  || .   .|..|| . ..|.  .|  ||.||....   .. |.  ... ||. .|.. ||   | . ...||....|.|   .  ... |
dlgkdrca.vywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGet.rsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastp

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
| | ||.|||||||||.|  .|..   |  .|.|. || || .| .||.| 
ilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 692-925 3e-59 195.5 In-house 39-266 (315) alignment 
Range on Protein: 692-925
Range on HMM: 39-266/315.0
HRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
| .  | |  || |||..||..|.  ||.| ..   ..|||.||..|| | ..| |.|.|||  ..|.||||...|..   |||||.| |.... .  ||
hpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekyw

SDLeSRQFGEITIELIKKKEEIDYLHRQFKIAHLEQpeaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYiTlRTTEPITVMCSSGVGRTGVFIAL
 |     .|.||. ..... . .|  | . .   ..     ..  ...  ||. ||| ...||...|..|.    |  .  .| | ||.|||||| ||.|
pdk.kviyGkitvtrkseevnteytvrtlsvvfgdn...irevvqlhytswpdmgvpkytiplmnlirtvkqhh.t.nsvgaivvhcsaGvGrtGtfitl

GIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
  ||..  .| .||... .. .| .|  |||.  
davldqaeaenaidvynfitgvrqnrikmvqvae
subfamily_PTPN14_pd Subfamily PTPN14 375-643 5.9e-59 194.5 In-house 18-293 (300) alignment 
Range on Protein: 375-643
Range on HMM: 18-293/300.0
MRMNDNQRFMeEFGTIPMN-PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQeGSDYINASFLDGFM--KPQQYIATQGPMAETIGEFWRMVWE
..... . |. |.  || .      ..|. . |  |||. ..|||...||.||. | .  ..||||| .   .  | ..||..|||.  |. .||.||||
kkleegkvft.eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWe

QNSATIVMVTKLQEKSTVKCDCYWPTD--VNERCTYGGVEVTLVECVPLANYTFRTFTIMKgGTSKDLREVRQFHFTAWPDHGVPEFPTSMLS---MIRC
|. . |||.|. .|.   |.  |.| .   ... ..|  .||         .. .....     ||. |.|  . .| |||||||| ....||   ... 
qgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkh.lpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

VRAHHNRLPP---DTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEdNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
|| . |.  .      |..|||||||||||  .. | ... . |.| ..||   .. ||.|| ..|||  || |..... 
vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehne.eidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 702-930 3.1e-58 192.0 In-house 28-259 (274) alignment 
Range on Protein: 702-930
Range on HMM: 28-259/274.0
NKGKNRFVNIMPYEYNRVKLSFIRAT-EGSDYINASYIDSYRQ-QRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESR--
.. |||. .|.| |  || |.   .. | |.|||| ||  |.. ..||.|||||. |||.||||||.......|||||||.|....    |. | |.   
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

--QFGEITIELIKKKEEIDYLHRQFKIAHLEQPEAsytLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTT-EPITVMCSSGVGRTGVFIALGIV
  ..|.. |.  |..|. ||  |.. . .||..     ..|. .  ||.. .| .| .||.....|.|   .  .   |. | ||.|.||||.|||  | 
serygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LERYSVEGMIDLFQTVKTLRIQRSAMVQTRlSQKKI
. .   |...|....|  ||..|  ||||. .| ..
vrqlreeivvdvlkivcnlrldrGGmvqts.eqyel
subfamily_PTPN23_pd Subfamily PTPN23 673-930 3.4e-58 191.8 In-house 13-272 (288) alignment 
Range on Protein: 673-930
Range on HMM: 13-272/288.0
ESSLLEMEFQRLATDRTEP-HRFASATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQ-RAYLATQGPMKNTVEDFWRMIWEHKS
. . |. .|. | ..  .  . .. |  ...  |||. .|.||. |||||      .  ||||||.. .   .   ..|||.|...|. |||.|..| ||
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

KIIVMLTKLEEKQQECSFLYWSDL--ESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQpEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITL
..||||.. ||....    ||     |. .||.... | ...|   . .|..|. .|.. .| ... | |.  ||| ||| |   |||....|.. | . 
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda.davksvshlqltsWpelGvPasPetllqfldevesayeav

--RTTEPITVMCSSGVGRTGVF-IALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLSQKKI
  ..  |. | ||.|||||||| .  ..| | .  .|..|. | |..|| ||  |||..   |. 
qrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfs
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 404-643 1.7e-57 189.4 In-house 36-274 (287) alignment 
Range on Protein: 404-643
Range on HMM: 36-274/287.0
ECNLAKNRYDNILPYDHTRVKLSTvKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDvNERC
  .  |||| ..||.|.||| ||. . . ||||||| .. .. . ...||.|||.| |...|||.|.|..||.....|.  |..  ||  |||   .   
laavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPm

TYGGVEVTLVECVPL-ANYTFRTFTIMKGGTsKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAH--HNRLPPDTGPMIVHCSAGVGRTGTFVVIDS
  ||  |.|..   .  .|. |.. ...  | .. | |.|... .|||....    ... ..  |. |   .|   ..||..||...|.||.|... .  
rvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlv

MLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
...| .    .||.   |  ||..|. .||.  |. .. ||. 
lvsrled.lGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_CG7180_pd Subfamily CG7180 685-923 1e-56 186.8 In-house 25-275 (296) alignment 
Range on Protein: 685-923
Range on HMM: 25-275/296.0
ATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQ
 | | |    | . .. |..||| |...||.|||| |. .   | ||||||.|.||. ....|. |..|.|.||..|||........ .|.|||  . ..
ltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak

ECsFLYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIAHL-------EQPEA--SYTLHHFQFLGWPE-RGVPVSALPLLQMIQNVQELYITL---RTT
 .   ||      |.||| .|....|.  .   |.||. .        |...     ....||.  |.    ||.|.  |..... |. .        ..
my.psywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

EPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQT
.|. |..| |..|.||..|. . ||  . |. .|.|. |||||..|  .|..
gPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven
subfamily_PTPN3_pd Subfamily PTPN3 668-931 1e-55 183.6 In-house 8-267 (280) alignment 
Range on Protein: 668-931
Range on HMM: 8-267/280.0
IQEDGESSLLEMEFQRLATDRTEpHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfirATEGsDYINASYID----SYRQQRAYLATQGPMKNTVEDFWR
..|. ||  . ..|..|   . .      | |  |  |||. .|.||.  ||||.   ..|  |||||.|..    |  .   |.|||||...|..|||.
lkeglesGavlaqfeqlyrkkpg.laisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWq

MIWEHKSKIIVMLTKLEEKQQECSFLYWSDL-ESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQ
|.||.||..||||| | |. .     || .  .. ..||..... |..|.  |. |.. . . |. | . .....|.| ||. ||| ..  .|.....|.
mvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketke.erkilqlqylaWpdhgvPddsadflefvervr

ELYitLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRlSQKKIV
.|     ..||. | ||.|.|||||.|.| . |     .  .   . |.|.| ||...|||  || | |
klr..sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta.sqykfv
0041856 (Phosphotyrosine protein) phosphatases II 406-651 3e-55 181.9 In-house 1-176 (182) alignment 
Range on Protein: 406-651
Range on HMM: 1-176/182.0
NLAKNRYDNILPYDHTRvklstvkwqeGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTklqekstvkCDCYWPTDVnercty
|| |||| .||||||.|          ..|||||....| ......||||||. .|. .|.||..|..  |||..|         ...|||...      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

ggvevtlvecvplanytfrtftimkggtskdLREVRQFHFTAWPDHGVPEfPTSMLSMIRCVRAhhnrlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRi
                                |.. |.... |||||||. . ..|..|. |..       . || .||||||||||||.|... |... 
...............................erlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl.

lhgedNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVT
     .|...  | |.|..|. ||.|..||||.. |. | . ...|
.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 376-654 1.6e-54 179.7 In-house 4-274 (283) alignment 
Range on Protein: 376-654
Range on HMM: 4-274/283.0
RMNDNQRFMEEFGTIPMnPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWqegsDYINASFLD---GFMKPQQYIATQGPMAETIGEFWRMVWEQ
| |.|. |.| .  . . |  . ..|  . |  |||...|.|.|  ||.| .       |||||.|.       . ..||..|.|. .|. .||.||...
rvnnnklfrevlkrlsv.pdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

NSATIVMVTKLQEKSTVKCDCYWPTDVNErcTYGGVEVTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFptsMLSMIRCVRAHHN
. ..|||.|||||   .||  ||| .  |   ||   ||| . .    .. . ... . ...|.   .  . .  | . |       . |...  .   .
kitaivmltklqedlrikCsqyWPkrGse..dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqai...inslvkfnkvisl

RLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILhGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVT
.     ||..||||.|.|||..|. . . .. .|  |  ||..  |. .|.||  .||| ||| ..||.. |   || |...
qteskkgPivvhCstgiGrtavfiaasasvkdal.tesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_PTPN14_pd Subfamily PTPN14 669-935 9.2e-54 177.5 In-house 17-292 (300) alignment 
Range on Protein: 669-935
Range on HMM: 17-292/300.0
QEDGESSLLEMEFQRLATDRTePHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATeGSDYINASYIDSY--RQQRAYLATQGPMKNTVEDFWRMIW
..  |.. . .|..|..  |.    . .|. ..|. |||| ...||| |||.||  . .  ..||||| |      ..| |...|||...||.|||.|.|
ekkleegkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvW

EHKSKIIVMLTKLEEKQQECSFLYWSDLES----RQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQ
|.. ..|||||. ||. .| || |. .|||     .||.  .    ...   .  ...|. ||   |   |..|.|.  ||..|||    . |. ...||
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske.ertvwhlqytDWpdhgvPeDvkgflsyLeevq

ELYITLRTTE-------PITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKIVLSLK
 .     ..        |. | || ||||||| |   .... .  .  ||. .....|| ||  .||| |.| | | .. 
svrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqt.laqYkfvYkvl
subfamily_PTPN13_pd Subfamily PTPN13 694-924 1.4e-53 176.9 In-house 29-255 (273) alignment 
Range on Protein: 694-924
Range on HMM: 29-255/273.0
FASATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSdYINASYIDSY--RQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
  .. |. || |||. |..||.  ||||.     ||. |||||.|      ..  |.|.|||. .||.|||.|.|| |...|.|.|.  ||..     ||
cevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

SDLESRQF---GEITIELIKKKEEIDYLHRQFKIAHLEQpEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYItlrTTEPITVMCSSGVGRTGVF
 . ....    . ...||.| ..  ..  |.... ..|  ..|  . |..|  ||. ||| ||..|||....|..|      . || | ||.|.||.|..
Pesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrsGtl

IALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
|.. .||.  . .  .|. ..|..|| || ..|||.
itidvvlglierdkefdvkeivrklreqrqgvvqtk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 681-925 2.9e-53 175.6 In-house 1-251 (270) alignment 
Range on Protein: 681-925
Range on HMM: 1-251/270.0
FQRLATDRTEPHRFASATKnvNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSY-RQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKL
|..|  ..|... . .|..  .|  ||. .|.|    ||.|. .. .. . |||| |.  .  ....|.|..||...|...|||||||.|.. |||.|.|
fkeldkeetsesdlpeaar..gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgl

EEKQQECSFLYWSDLESR----QFGEITIELIKKKEEIDYLHRQFKIAhlEQPEASYTLhHFQFLGWPERGVPVSAL------PLLQMIQNVQELYITLR
||| ..    ||.    .    ..|.|..  .... |  |. .. ..   |. |    . ||..  ||..||| ..        ||.|...|..    |.
eEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeld

TTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
 .||. | || ||||||..||| |...  . .. .|. . .. || .| |.||.  
kaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpe
subfamily_PTPRN_pd Subfamily PTPRN 675-931 1.3e-52 173.4 In-house 29-284 (297) alignment 
Range on Protein: 675-931
Range on HMM: 29-284/297.0
SLLEMEFQRLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYI-DSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKII
. || |.. |.. ..||.  . | .. |  |||  ...||. .||||.   ..| ||||||| | |.  .. ||.|||||. .|| |||.|.||. . .|
drlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

VMLTKLEEKQQECSFLYWSDLESRQFGEITIELIKKKEE-IDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITlRtTE
|.||.|||.. .    || |  |  ..   ..|. ..    ||| | | .  |.. | . |.  | || |||.||| || .||.. . |.  |   | . 
vnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse.trtvtqfhflswpeegvPasaksllefrrkvnksyrG.r.sc

PITVMCSSGVGRTGVFIALGIVLERYSV-EGMIDLFQTVKTLRIQRSAMVQTRlSQKKIV
|| | ||.|.|||||.|.. .||.|       ||.  |.. || ||. .|.|. .| ...
pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktk.dqfefa
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 677-926 1.9e-52 172.8 In-house 12-265 (287) alignment 
Range on Protein: 677-926
Range on HMM: 12-265/287.0
LEMEFQRLATD-RTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFiRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVM
.. |...|  | .. .  | .|..  .  |||. ...|.. .|| ||   .  ||||||| |. ||... |..|.|||.  || ||||...|..|  ...
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LT-KLEEKQQECsFLYWSDLES-RQFGEITIELIK-KKEEIDYLHRQFKIAHLEQPEASyTLHHFQFLGWPERGVPVSALPLLQMIQNV-Q--ELYITLR
.| ..|| ...| . || . |   . |  .. |.. .. | .|  | .....||  ||   .. ...| ||..... .|. |.... .| |  ||     
mtreveearlkc.ykywPerevPmrvGGysvvlldydikePeygvralrlidletrear.vvkqldllswPdkvlaPtavglirfvldvkqhielardas

TTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLS
 . |. | .. |.||.|...|. ....|    | .|  ..|  || .| |.||. . 
evGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvq
0051429 (Phosphotyrosine protein) phosphatases II 433-650 4.5e-52 172.7 In-house 3-228 (272) alignment 
Range on Protein: 433-650
Range on HMM: 3-228/272.0
GSDYINASFLDGFMK---PQQYIATQGPMAETIGEFWRMvWEQNSATIVMVTKLQEKSTVKCDCYWP----------TDVNERCTYGGVEVTLVECVPLA
 |.||||....|. .   |  .....||.  |. .|||. .|..  |||..... |.  .|||.|||           |. .. .|| . |||.... | 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

NYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEfpTSMLSMIRCVRAhhnrlppdTGPMIVHCSAGVGRTGTFVVIDSMLqRILHGEDNVD------
.|. |......  . .. |||...|.|.|||||||.   ..|.... ...         ||..||||||..||||.|... .| . .. |. ||      
dyilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltn

--IYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAiACGV
  ... |  || ||  .||||.|| |..||. |. ....
lyleeaveelraqrpgavqteeqylflyeallel.lrsl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 695-932 2.9e-51 169.0 In-house 26-259 (283) alignment 
Range on Protein: 695-932
Range on HMM: 26-259/283.0
ASATKNVNKGKNRFVNIMPYEYNRVKLSFIRAtegsDYINASYID---SYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
  |. . || |||. .|.|.. .||.|         |||||..|    ||.|.. |...|.|...|| |||.|....|   ||||||| | ...    ||
diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

SDLESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERG--VPVSALPLLQMIQNVQelyiTLRTTEPITVMCSSGVGRTGVFI
    | ..|| |. | |   .  .  ... . .    ...  | |.|. .| | |   .. .|  .  ..  |    |     || | ||.|.|||.|||
PkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislq....teskkgPivvhCstgiGrtavfi

ALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKIVL
|.   ..    | ..|.|..|| .| ||  .||| | | |.| 
aasasvkdaltesvvdvfavvkimreqrmmavqt.ldqyklvh
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 378-649 1.3e-50 166.8 In-house 12-296 (301) alignment 
Range on Protein: 378-649
Range on HMM: 12-296/301.0
NDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKW--QEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSA
. ...| |.. ..  .  .. .|   | | | ||. || .||. |. |.. .   .   .|||||..||. . ...||.|||| .|. .|||..|..  .
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

TIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTIM--KGG------------TSKDLREVRQFHFTAWPDHGVPEFPTSML
.|||||.|.|..  ||  |||.  .|. ..| ..||||.   . ... | ....  .|             ..|. ..| |.. | ||..||   |  .|
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

SMIRCVRahHNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACG
  |  |   | .  .. ||..||||..|.|.|... ..  |      |  ||... .  .| ..  .|.| .|| .|...|.. ... 
qviddvi..hrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQc.kaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
0036282 (Phosphotyrosine protein) phosphatases II 433-640 1.3e-50 166.8 In-house 1-164 (174) alignment 
Range on Protein: 433-640
Range on HMM: 1-164/174.0
GSDYINASFLDGFMKPQQYIATQGPMAetigeFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTdvnerctyggvevtlvecvplanytfrtftimkgG
||||||||.||... .  .||.|||.|     ||.|..|... |.||.....|.  .||  |||.                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................l

TSKDLREVRQFHFTAWPDHGVPEFPTsMLSMIRCVRAHHNRlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILhgEDNVDIYGHVTLLRNQRNFMVQTE
 .   |.. |.... |||||||.... .|.... |. ....  .. ||..||||||||||||.|... ||...|  |. ||.. .|  ||.||  ||||.
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtp

DQYFFIHE
.|| |...
sQyrflyy
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 677-927 3.4e-50 165.5 In-house 17-281 (301) alignment 
Range on Protein: 677-927
Range on HMM: 17-281/301.0
LEMEFQRLATDRTEphRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRA--TEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
.| ....| . . .  .    ... ||  ||| || .|. ||. |.  ..  .   .||||||||.|...... |.|||||.|. ||||.||..|   ||
feeqykelkegedk..sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLTKLEEKQQECSFLYWSD--LESRQFGEITIELIKKKEEIDYLHRQFKI--------------AHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMI
|.|.|.|....... ||..   || .||..|..|....   |.. ||...               . ..  .|...  .|   ||. ||       || |
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvi

QNVQELYITLrTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQ
..|           |. | || .|.|.||.... | ||    || .|.|| .|..| ..  .|.| | |
ddvihrqqki.gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtT.Leq
subfamily_ptpA1_pd Subfamily ptpA1 401-608 1.6e-48 160.5 In-house 42-259 (418) alignment 
Range on Protein: 401-608
Range on HMM: 42-259/418.0
ANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFmKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVN
 . . | .|||| |||| .||||.|  .. .|||||||| ..||   |.|.|.||||. .|| .|||||||.    |||...  |.  .||| ||| .. 
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

---------ERCTYGGVEVTLVECVPLANYTFRTFTIMKgGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLPPDT---GPMIVHCSAG
             .|   | ||| .   .    |  |       . |.. |...  |||| .|..   .  ... .  ..|.. | .    |.|||||||
geqfsiygngnevfgtysvelveviqdpereiitrnirl.tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

VGRTGTFVVIDSMLQRILHG
|||||||.    |.... | 
vgrtgtfctavimmkkldhy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 381-642 2.8e-48 159.5 In-house 16-273 (307) alignment 
Range on Protein: 381-642
Range on HMM: 16-273/307.0
QRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVkwQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMV
|....||  .     .   |  ...|  ||||...   |..|. . .      |||| | .|   .||...|..|||. .|. .|| |. ...  ...|.
qalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfd..glasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLV----ECVPLA-NYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAhhnrlp
 |. | . .||. ||| .  .. ..|    |.      .  || .  .   | .|   ... | .... .. |||.|||.   . . ..  ||       
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry......

pDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
 || |..|||||||||.|| | |  . .... |..  |.   |  ||.||.. .||| ||...|  .
.dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 667-925 4.9e-48 158.5 In-house 12-223 (392) alignment 
Range on Protein: 667-925
Range on HMM: 12-223/392.0
LIQEDGESSLLEMEFQRLATDRTEPHRfaSATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIW
.....  |.|.  ||. |      |..  .| |..|. |||. ||.||. .||||  |  .  |||.|||||.|. ...||.|.|||   ...|||||..
fveknrhsalffeefhdlpgpdiypqt..vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvf

EHKSKIIVMLTKLEEKQqecsflywsdlesrqfgeitielikkkeeidylhrqfkiahleQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYI
...   |.|.|||.| .                                           . .   |   |.|  ||...||  .  ||..|..|.  . 
qenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfG

TLrtTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
    | |. . ||.||||||| |..  |. .     |.|.|. |  .| .|  ||||. 
qy..thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtke
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 656-923 1.4e-47 157.1 In-house 5-264 (439) alignment 
Range on Protein: 656-923
Range on HMM: 5-264/439.0
DQFPVHLDKLEliqeDGESSLLEMEFQRLATDRTEPHRFA-SATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPM
|.|  |..||.      .  ... .|. . . . . .  |  |... .. |||. .. .... || |  |     | |||| ||. | ... |.||||| 
defqehvekld....knkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpk

KNTVEDFWRMIWEHKSKIIVMLTKLEEKQQecsflYWSDLESRQFGEITIELIKKKEEIDYLHRQFKIA-HLEQPEASYTLHHFQFLGWPERGVPVSALP
|.|..||||...|.|.  |||||.| |  .     ||   .   .|.|..   .. |  .|  | ||.  . .. |   |. .|... ||.. ||  |  
kettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqash

LLQMIQNVQELYiTLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQT
.|.... ..      . . |. | ||.||||||  ||| | ||.  .|  .|.   || || ||  |||.
vldflrainsan.dkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqa
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 381-642 3.3e-47 155.5 In-house 31-279 (290) alignment 
Range on Protein: 381-642
Range on HMM: 31-279/290.0
QRFMEEFgtIPMNPGHPKEVANYECNL--AKNRYDNILPYDHTRVKLSTVkwqEGSDYINASFLDGFMKpqQYIATQGPMAETIGEFWRMVWEQNSATIV
. ..|.    |  |... |   .. |    |||| ..   | ||| |.        ||. | ...|      .| |||....|. ..|||| ... |.||
keylekl..kpylpvqylerkifdkntefkknrykdvvcndktrvilkdG...ydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaiv

MVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVE-CVPLANYTFRTFTIMKGGTSKDlREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHhnrlppd
|. .| |.   ||. |.|    |  |.| . |.  |   . ||   .|.....  . |.   .. ..  .|||. |.    ..| ..| .|         
mlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGke.hklkhlkikswpdksvalstlallrtlrilrka.......

TGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEdNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
.||..||||||.||||||| |.  || .|.|  ..|. . |  ||| |   || . ||. . |..
sGpvvvhcsaGiGrtGtfvaievglqilldGk.eldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 696-925 5.9e-47 154.8 In-house 2-228 (239) alignment 
Range on Protein: 696-925
Range on HMM: 2-228/239.0
SATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYR-QQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL
.| | ||| |||. ||. |...|| |  .     ||||||||.  |    .||.|||| .. .  |||||.|. .  .||||| | | ...  . || | 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

ESRqFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTlHHFQFLGWPERGVPVSALPLLQMIQNVQElyITLRTTEPITVMCSSGVGRTGVFIALGIV
 |. . .. . | | .   ||. | | .... | |  |  ....|  ||..|||  |  .| . ... .   .|  . |  . ||.|||||| |. .  .
tsk.ycnlrvtlrktevfadyiirtfvmsqvgqteeryv.yqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidam

LERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
| .   .  .|.|. ||..| .|  ||||  
lrqakkqktvdifnyvkairedrphmvqtse
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 697-925 7.7e-47 154.4 In-house 2-227 (239) alignment 
Range on Protein: 697-925
Range on HMM: 2-227/239.0
ATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYR-QQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLE
| | ||| |||. ||. |...|| |  .     ||||||||.  |    .||.|||| .. .  |||||.|. .  .||||| | | ...  . || |  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SRqFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTlHHFQFLGWPERGVPVSALPLLQMIQNVQElyITLRTTEPITVMCSSGVGRTGVFIALGIVL
|. . .. . | | .   ||. | | .... | |  |  ....|  ||..|||  |  .| . ... .   .|  . |  . ||.|||||| |. .  .|
sk.ycnlrvtlrktevfadyiirtfvmsqvgqteeryv.yqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidaml

ERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
 .   .  .|.|. ||..| .|  ||||  
rqakkqktvdifnyvkairedrphmvqtse
subfamily_PTPN1_pd Subfamily PTPN1 692-924 1e-46 154.0 In-house 22-257 (290) alignment 
Range on Protein: 692-924
Range on HMM: 22-257/290.0
HRFASATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW
.. ..| .. |...||. .. ||.. |.||      .  |||||| ..  . .| |. ||||. |||. ||.|.||.||| .||| |. ||.|   . ||
fptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

SDLES---RQFG--EITIELIKKKEEIDYLHRQFKIAHLEQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTG
   |.    ..   .....||.....  |  |....  |.  | . .. || .. ||. ||| |   .|.....|.|     .   |  . ||.|.||.|
Pqgeeekellledtklkvkliseerksyytvrllelenlktqe.treilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

VFIALGIVLERYSVE---GMIDLFQTVKTLRIQRSAMVQTR
 |. .  .| .   .     .|. ...  || .|  ..|| 
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqta
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 702-924 1.8e-46 153.3 In-house 3-225 (237) alignment 
Range on Protein: 702-924
Range on HMM: 3-225/237.0
NKGKNRFVNIMPYEYNRVKLSfiRATEGSDYINASYIDSYRQ-QRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLES-RQF
|| |||. ||. |...|| |    |  |||||||.|....    . |.|.|||.... .|||.|.|. |  .||||| | |....    || . .  . .
nkiknrygnivaydhsrvvlk..gagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYS
| .|. | ||.|  ||  | . ...  . .    .| .||  ||.||||  .  ||.. .|. .    .  . |  . ||.||||||.|. .  .| .  
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

VEGMIDLFQTVKTLRIQRSAMVQTR
 . ..|... |...  .|  ..||.
ekkvvdiynyvysieedrpyiiqtk
0043147 (Phosphotyrosine protein) phosphatases II 432-640 2.1e-46 153.1 In-house 3-155 (172) alignment 
Range on Protein: 432-640
Range on HMM: 3-155/172.0
EGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLqekstvkcdcywptdvnerctyggvevtlvecvplanytfrtftimKG
|||||||||.||.  .|...||||||. .|. .||||..|..  .||..|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................ly

GTSKDLREVRQFHFTAWPDHGVPeFPTSMLSMIRCVRAHHnrLPPDTGPMIVHCSAGVGRTGTFVVIDSMLqrilhgeDNVDIYGHVTLLRNQRNFMVQT
 ...  |.. |.... |||||||  .  .|.... .. ..  .  . ||..||||||||||||.|... ||        .....  | |.|..|. .||.
dpellerlgiqylylpwpDhgvp.llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqn

EDQYFFIHE
..|| |...
psqyrflyy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 402-642 2.3e-46 153.0 In-house 29-291 (297) alignment 
Range on Protein: 402-642
Range on HMM: 29-291/297.0
NYECNLAKNRYDNILPYDHTRVKLSTVKwqEGSDYINASFLD--GFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDV
. .  | |||| .|| .| |||||  |    ..||||| ..      .. .|| .|||. .|. .||..|.||.  .||||.||||    ||  |||  |
krnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

NERCTYGGVEVTLVECVPLAnYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVP-------EF----------PTSMLSMIR--------CVRAHHNRL
.|| . | | |  .  .    .    .| ..    .. | ||   | .|||||||        |             ||...          . . .   
qerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraem

pPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
 |   ...|||||||||.|  |  | .|... . .   |.   .. ||.||  .||| .|. ....|.
.prnayllvhcsaGvGrsGvvvlsdvilaklrk.kripdvaailsilreqrarlvqtleqfellydav
0049772 (Phosphotyrosine protein) phosphatases II 391-646 1.6e-45 151.5 In-house 31-280 (314) alignment 
Range on Protein: 391-646
Range on HMM: 31-280/314.0
PMNPGHPKEVANYECNLAKNRYDNILPYDhTRVKLSTVKWQeGSDYINASFLDGFmkpQQYIATQGPMAETIGEF----------WRMV--WEQNSATIV
 . | .   ||....|  |||| .|||.| .||.|...  . ||||||||..|||   ...||||||. .|.  |          ||||  ...|. .||
svlpeltilvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------VTKLQEKStvkcDCYWPTDVNERCtyggvevtlvecvplanY-------TfrtftimkggtskdLREVRQFHFTAWPD
|                      ..| ..     . ... |. . .                                         |.. ... . .||
msrdevladelsrLdaAlgKtpllildgng....neptaadlellk.................eelydpelf..............erlgikylripvpD

HGVPeFPTSMLSMIRCVRAHhnrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlhGEDNVDIYGHVTLLRNqRN---FMVQTEDQYFFIHEAINEAI
...|  .  ...... ....     .. || .|||.||.||||||||.. .. .   | .  ... .| | |   |    .... .|| ||.||..|..
gsap.lledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll..gvsleealedvrlkRp.inpnpgfieqleqyefilealleyl
0046846 (Phosphotyrosine protein) phosphatases II 431-643 2.4e-43 143.2 In-house 9-170 (176) alignment 
Range on Protein: 431-643
Range on HMM: 9-170/176.0
QEGSDYINASFLDGFMkpqqYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCtyggvevtlvecvplanytfrtftimk
....|||||....| .    .||||||. .|. .|..|..|..  ..|..|...|.. .||. |||   .. .                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

ggtskdlrevrQFHFTAWPDHGVPEFpTSMLSMIRCVRAHHNRlppDtGPMIVHCSAGVGRTGTFVVIDSMLQrilhgEDNVDIYGHVTLLRNQRN-FMV
           |.... |||||||.. . .|.... .| . ..   . || .||||||.|||||.|... .       | .....  . |.|.||  ..|
...........qylhlpwpDhgvpdl.elllellefirealke...g.gpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplgav

QTEDQYFFIHEAIN
||..|| |..|.. 
qtpeQyrflyefel
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 406-644 6.1e-43 141.7 In-house 33-257 (267) alignment 
Range on Protein: 406-644
Range on HMM: 33-257/267.0
NLAKNRYDNILPYDHTRVKLSTVKWQegsdYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKstvKCDCYWPTDVNERCTY
| ..||.|. ||||.||| |.| . .    |||||...|. . ...|.||.|.  ||..|. .. .|. ..||..||  .    .   .||  . .   |
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakky

GGVEVTlvECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGvpeFPTSMLSMIRCVRAhHNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQRI
  . |    ..   .  ..  |.      .  ..|  ...  |            |  .  . | .|.|     |..|.||.||||.|||.||||.|.|.
qdltve..hslekeendyqiitlelkfknesahnvtlyyykkwnint...nnkpylkplfgila.knqlengnrPlvvacsdGvGrsGtflvidsqlera

lHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINE
   |. .||.  .  .|.||  .|.| ..| .||| . |
.ktegvsdifdflrkirsqriglvdtkeryiyihellae
0051429 (Phosphotyrosine protein) phosphatases II 729-925 6.3e-43 142.7 In-house 3-212 (272) alignment 
Range on Protein: 729-925
Range on HMM: 3-212/272.0
GSDYINASYIDSYRQ---QRAYLATQGPMKNTVEDFWRMiWEHKSKIIVMLTKLEEKQQECSFLYWS------------DLESRQFGEITIELIKKKEEI
 |.||||.... | .    .......||...|..||||. .|.. | ||.|...||....  ..||             . ..  .| ... |....   
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSAlpLLQMIQNVQElyitlrtTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMID--------
||..| . . .| .........|.....|| .||| .|  ||.... ...        .|. | ||.|..|||...|| ..|.. | | ..|        
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

LFQTVKTLRIQRSAMVQTRL
|...|. || || ..|||  
leeaveelraqrpgavqtee
0049260 (Phosphotyrosine protein) phosphatases II 441-640 2.1e-42 139.7 In-house 1-144 (152) alignment 
Range on Protein: 441-640
Range on HMM: 1-144/152.0
FLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWptdvnerctyggvevtlvecvplanytfrtftimkggtskdlrev
|.||...|...||||||. .|. .||||..|..  ||||.|.|.|.  .||. |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

rQFHFTAWPDHGVPEFPTSMLSMIRCVRAHhnrLPPDTGPMIVHCSAGVGRTGTFVVIDSMLqrilhgeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHE
 |.... |||||||...  .| ... .. .   .  . || .||||||||||||.|... ||        .|...  | |.|..|. .|....|..|..|
.qylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 358-642 2.9e-42 139.4 In-house 6-285 (305) alignment 
Range on Protein: 358-642
Range on HMM: 6-285/305.0
NTHPTIHNYQFPA-HLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKwqeGSDYINASFLDGFMKPQ-QYIATQ
.||| ....   |  . | .. .. | .  .    |     .     . . .||||...   |.. |||.       |||| | ..   | |. ..|..|
qthpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaq

GPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTY-GGVEVTLVE-CVPLANYTFRTFTIMKGGTSKD-LREVRQFHFTAWPDHG
||. .|| ||| || ...   |||. |  |   .||  |||.   |. .  .|. |  |  . |.   .    |...   | |    ||....| ||| |
gpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrg

VPEFPTSMLSMIRCVRAHHnrLppdtgPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
||    . | .. ..|  .  .     |..||||||.||||| | |. .|..|    .   .   |  ||.|| | .|.. ||.|||  .
vppckltslellsairgsk..v.....pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvm
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 407-642 4.7e-41 135.5 In-house 49-283 (305) alignment 
Range on Protein: 407-642
Range on HMM: 49-283/305.0
LAKNRYDNILPYDHTRVKLsTVKWQegSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYG
  |||| ..   |. ||||    |    .|| | ..    .|...| || |. .|  .|| | ....  .| |. .|.|| . ||  |.... ..  .. 
agknrykdvgcldnnrvkl.egpwp..heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

GVE-VTLVECVPLANYTFRTF--------TIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRahhnrlpPDTGPMIVHCSAGVGRTGTFVV
  .    | .   ... ||.          ..  |. .. | | ..|.  ||| |||   ...| ..   |       |  ||..||||||.||||. |.
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.......pskgpivvhcsagigrtgsvvm

IDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
.. .|...| |.   |    .  .|.|||  .||..||.|.|. |
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi
0041856 (Phosphotyrosine protein) phosphatases II 702-924 1.8e-40 133.8 In-house 1-157 (182) alignment 
Range on Protein: 702-924
Range on HMM: 1-157/182.0
NKGKNRFVNIMPYEYNRvklsfirateGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTkleekqqecSFLYWSDLEsrqfge
|. |||...|.||...|          ..|||||....... .. ..|||||...||.||.||..|.. ..||.||         ..||| .|.      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

itielikkkeeidylhrqfkiahleqpeaSYTLHHFQFLGWPERGVPVsALPLLQMIQNVQElyitlrTTEPITVMCSSGVGRTGVFIALGIVLERysve
                               . .....|.||  |||     ||..|. |.|        .|. | || ||||||...|. .....    
.............................erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....

GmIDLFQTVKTLRIQRSAMVQTR
| ..|...||..| .|. ||.| 
g.vsleeavklvrsrRpgmvitp
0049772 (Phosphotyrosine protein) phosphatases II 690-922 7.3e-40 133.0 In-house 34-264 (314) alignment 
Range on Protein: 690-922
Range on HMM: 34-264/314.0
EPHRFASATKNVNKGKNRFVNIMPYEyNRVKLSFIRaTEGSDYINASYIDSYrqqRAYLATQGPMKNTVEDF----------WRMI--WEHKSKIIVM--
 .. .  | . .|. |||. .|.|.. |||.|..    .|||||||||.|..   ....|||||...||.||          |||.  ..... .|||  
peltilvadlflnrdknryldilpad.nrvilpglp.vsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsr

-------------------LTKLEEKQqecsflywsdlesRQFGEITIELIKkkeEIDYLHRQFkiahleqpeaSYTLHHFQFLGWPERGVPvSALPLLQ
                   |..| ...              .  . ..||.|   |. | .  |          . .  ..  . .|  ..| .   ...
devladelsrLdaAlgKtpllildgng.............neptaadlellk...eelydpelf..........erlgikylripvpDgsap.lledfde

MIQNVQELyitlRTTEPITVMCSSGVGRTGVFIALGIVLERYsveGMiDLFQTVKTLRIQRS-----AMVQ
... ..|.    .. .|. | |..|.||||.|....... ..   |. .| .... .| .|.      ...
flefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfie
0044763 (Phosphotyrosine protein) phosphatases II 417-642 2.5e-39 130.1 In-house 1-167 (178) alignment 
Range on Protein: 417-642
Range on HMM: 1-167/178.0
PYDHTRVKLSTVKWQEGSDYINASFLDGFmkpqQYIATQGPmaetiGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNerctyggvevtlvecv
|.|.|||.||.. . |.|||||||. ...     |.....|      .......|..  .||..|. .|   .||| |||.. .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

planytfrtftimkggtskdlrevRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRilhgedNVDIYG
                         |.... .||||||. .  .| ... ......   .. || .|||||||||.||.|... |...      ..... 
........................iqylhipipDhgvpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlvaaylmkkl......glslee

HVTLLRNQRNfMVQTEDQYFFIHEAI
 . |.|..|. .|....|. ...|  
aielvrerRp.ivpnpgqlrqLyefe
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 675-924 1.7e-38 127.1 In-house 6-245 (267) alignment 
Range on Protein: 675-924
Range on HMM: 6-245/267.0
SLLEMEFQRLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIV
  .| ||. .    ..  . .    . |. .||. . .||. .|| |.    |.  .||||||...|....|...||.|.|||. ||. .| ..|  .||
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MLTKLEEKqqECSFLYWSD-LESRQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQflGWperGVPVSALPLLQMIQNVQELYITLRTTEP
.|||  .   .   ..     ..... ..|.|   .||| ||    ...   ..     ||....   |    . .   | |. .  .           |
lltkvftd..nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyyk..kw...nintnnkpylkplfgilaknqlengnrP

ITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
. | || ||||.| |. .   |||   ||. |.|. .. .| || ..|.|.
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 382-642 7.1e-38 124.9 In-house 12-265 (281) alignment 
Range on Protein: 382-642
Range on HMM: 12-265/281.0
RFMEEFGTIPMNPGH-PKEVANYECNLAKNRYDNILPYDHTRVKLST-VKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVM
 | .||  .| .|      | |   |  |||| ||   | .||.|   .  .. .||| | ..   .  . || ||||  ||  .||||.|..|...|||
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

VTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVplANYTFRTfTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHhnrlppdTG
. .. |    ||  |.| .      .  . |.  .     | .. | | ..     . | . .. .  |||  |||    || ..| .||.       . 
lcqfletnrekcaeyfprnahcclqfdklsvsyedst..vnkslvt.trlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.......st

PMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRN-QRNFMVQTEDQYFFIHEAI
| ..||||||||.||.. ..  || |       ||   |. ||   |   ||| .||..| . .
ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 395-647 2.7e-37 123.4 In-house 32-272 (288) alignment 
Range on Protein: 395-647
Range on HMM: 32-272/288.0
GHPKEVANYECNLAKNRYDNILPYDHTRVKLStvkwQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCY
.  . . ..  | ...||.|.   | ||||||     .   ||.|  .     ... | .| |.  ||.|.|.|. |..   |||...| ||   | . |
asidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaey

WPTDVNERCTYGGVeVTLVECVPLANYTFRTFTIMKGGTSKDLRE-VRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrlppdtgPMIVHCSAGVGRTG
.|. . |.  .| .  | |           . ....     . .  |.. |.  |.|.||||   | | ..  ......       |..||.||||||||
fPsklGekarigrl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk.......PivvhssaGvGrtg

TFVVIDSMLQrILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIA
|...|  .|.  |  .|.. |   .. ||..|   .||| || ..|  . | ..
tlililiale.slrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
PTPc_DSPc_SM00012 540-643 4.8e-37 121.7 In-house 2-104 (105) alignment 
Range on Protein: 540-643
Range on HMM: 2-104/105.0
VRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLPPdTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIH
|...|.|.|||||||| ..|.|...| |. ..|     ..|..||||||||||||||..| .||.. .....|||.  |  ||.||. |||||.||.|..
vkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

EAIN
.|..
rall
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 401-654 9.8e-37 121.4 In-house 30-279 (285) alignment 
Range on Protein: 401-654
Range on HMM: 30-279/285.0
ANYECNLAKNRYDNILPYDHTRVKLStvkwQEGSDYINASFLDGFMKPQ-QYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDV
. ||.|   ||| ..   . ||| |     .   ||| ||..    | |  ||.||||. ||. .||.|..... | ..|.  | |    ||  |.|  .
tayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

NERCTYGGVEVTLVECVP--LANYTFRTFTIMKG--GTSKDLrEVRQFHFTAWPDHGVPEFPTSMLSMIRCVRahhnRLPPDTGPMIVHCSAGVGRTGTF
 |   .|  |.|| ||    .|   . ..|...    .|. |  . . .   |||.  ||    |. . . |.    .. |   |. |||||||||| ||
gevvkfgkyeitlteckeeaiagtilnaltvintedassepl.ymnhvqvpwwpdqlapedarpmielykwvk....kvnpkekpicvhcsagvgrtatf

VVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA-IACGVTDVT
| ||    ||.  . |...   |  .|  |   ||.  |..|..  . |  |  || . |
vgidyatirime.npniemldivremramrfqavqshmqflflyvvlmeyfigegvvert
0043147 (Phosphotyrosine protein) phosphatases II 728-924 4e-36 119.7 In-house 3-147 (172) alignment 
Range on Protein: 728-924
Range on HMM: 3-147/172.0
EGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLeekqqecsflywsdlesrqfgeitielikkkeeidylhrqfkiaHLEQ
||||||||||.| |.  . ..|||||. ||..|||||..|.. ..||.||.|                                             .  
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

PEASYTLHHFQFLGWPERGVPvSALPLLQMIQNVQELYiTLRTTEPITVMCSSGVGRTGVFIALGIVLerysvEGMiDLFQTVKTLRIQRSAMVQTR
.  . .  ....|.||  ||| ..  ||.... ..||.  |.  .|. | || ||||||...|. ..|     .|. .|...|...| .|. .||. 
ellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnp
0036282 (Phosphotyrosine protein) phosphatases II 729-923 4.5e-36 119.5 In-house 1-155 (174) alignment 
Range on Protein: 729-923
Range on HMM: 1-155/174.0
GSDYINASYIDSYRQQRAYLATQGPMKntvedFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDlesrqfgeitielikkkeeidylhrqfkiahlEQP
||||||||..| ..  . ..|.|||..     ||.|..|......|||....|.. .  . ||..                                 . 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

EASYTLHHFQFLGWPERGVPVSALpLLQMIQNVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLERYSvEGMIDLFQTVKTLRIQRSAMVQT
  . . .....|.|| .||| ..  ||.... |.| .       |. | || ||||||...|. ..| .   |...| ...|..|| ||. ||||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 687-930 7.7e-36 118.5 In-house 18-286 (297) alignment 
Range on Protein: 687-930
Range on HMM: 18-286/297.0
DRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLsfIRATEGSDYINASYIDSY--RQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQ
| ...  |.|| .|    |||. .|. .. .||||   |.  ..||||| |.      ..  |. .|||...||.|||....|.  ..|||..||.|  .
deargesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

ECSFLYWS--DLESRQFGEITIELIKKKE-EIDYLHRqfKIAHLEQPEASYTLHHFQFLGWPERGVP-----VS-----------ALPL-LQMIQ-----
.  . ||   . | .. |.. .| . .   | | ..      .|   . |  ..| |||.||. |||     .            |.|. | ...     
dkcapywpsvvqerlkagdvvveflsstsdefdrvil..telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftam

---NVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKI
   ... |        .. | ||.||||.|| .   ..|..   . . |    .. || ||. .||| | | ..
vflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqt.leqfel
0051082 (Phosphotyrosine protein) phosphatases II 433-642 1.7e-35 117.2 In-house 2-149 (151) alignment 
Range on Protein: 433-642
Range on HMM: 2-149/151.0
GSDYINASFLDGFmkpqqYIATQGPMAetigEFWRMVWEQNSATIVMVTKLQEKStvKCDCYWPTDVnerctyggvevtlvecvplanytfrtftimkgg
 |||||.|...|.     .....||.|    .|.....|..  |||......|    .| .|.|                                    
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

tskdlREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAhhnrlpPDTGPMIVHCSAGVGRTGTFVVIDSMLQRilhgednVDIYGHVTLLRNQRNFMVQTE
     .||...... |||.|.|... ..|.... ...      .. ||..||||||.|||||.|... ||..       |...  .  .| .|  .||..
.....ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpn

DQYFFIHEAI
.|..|.. |.
qqflfqlfal
subfamily_ptpA1_pd Subfamily ptpA1 683-896 2.1e-35 117.3 In-house 28-254 (418) alignment 
Range on Protein: 683-896
Range on HMM: 28-254/418.0
RLATDRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRqQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEK
||  .   |   .   |. |  |||. ||.| .. ||.|  |.  |||||||| |||     . ...||||. ||. |||||.|| . .|||||..  |.
rlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresen

QQECSFLYWSD-LESRQ----------FGEITIELIK--KKEEIDYLHRQFKIAHlEQpeASYTLHHFQFLGWPERGVPVSALPLLQM---IQNVQELYI
 .     || . .   |          ||  ..||..  .  | . . |. ...  |    .  . ..|. |||.. .|  . |. |.   | | |.  |
crikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf.eg..etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqii

TLR-TTEPITVMCSSGVGRTGVFIALGIVLE
       || | ||.|||||| | .  |...
pssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 699-925 1.5e-33 110.7 In-house 53-270 (290) alignment 
Range on Protein: 699-925
Range on HMM: 53-270/290.0
KNVNKGKNRFVNIMPYEYNRVKLSfirATEGSDYINASYIDSYRqqRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLES--
|| .  |||. ...  .  || |.        ||. | |..  .    .. |||..|.|| |.|||. ..|   |||| .| |. .     |. . |   
kntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

RQFGEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQelyitlRTTEPITVMCSSGVGRTGVFIALGIVLE
  |||||.   ..... . . ..       .   .. |.|..   ||.. |. |.| ||.... ..      ... |..| ||.|.|||| |.|. . |.
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr......kasGpvvvhcsaGiGrtGtfvaievglq

RYSVEGMIDLFQTVKTLRIQRSAMVQTRL
       .|| ..|..||  | . ||  .
illdGkeldlldlvralrnsrlnsvqvdi
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 402-654 3.4e-32 106.3 In-house 48-297 (310) alignment 
Range on Protein: 402-654
Range on HMM: 48-297/310.0
NYECNLAKNRYDNILPYDHTRVKLSTVKWQEgSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTdVNE
 |. .. |||| ...  | .||||   | .   ||| | ..      . .| .|||.  || .||||.... . .|... |  |.   ||  |||. .  
aykkymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgv

RCTYGGVEVTLV-E---CVPLAN--YTFRTFTIMKGGTSKDLREVR--QFHFTAWPDHGVPEFPTSMLSMIRCVRAHHnrlppdtGPMIVHCSAGVGRTG
  ||| . || . |      . |   ||    .       .|.|.|    ..  ||| |||.     .      .  |       || .||||||..|..
tetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh.......gpcvvhcsagkdrly

TFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEaINEAIACGVTDVT
. | ..  .... .| ..||.   .| |...|   .||| || .|.  .  ..| | |.|.
vvvalklkidkldrg.lkvdaeevktellksraiciqtelqyliidr.vriifargeteva
0049260 (Phosphotyrosine protein) phosphatases II 737-924 8e-32 105.4 In-house 1-136 (152) alignment 
Range on Protein: 737-924
Range on HMM: 1-136/152.0
YIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWsdlesrqfgeitielikkkeeidylhrqfkiahleqpeasytlhH
.|| |.......|||||. ||..|||||..|.. ..|||||.|.|.  ..   |.                                            .
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

FQFLGWPERGVPVSALPLLQMIQNVQELyiTLRTTEPITVMCSSGVGRTGVFIALGIVLerysveGMIDLFQTVKTLRIQRSAMVQTR
...| ||  ||| ..  ||.... ...|   |.  .|. | || ||||||...|. ..|        ..|...|. .| .|. .|.. 
ylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnp
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 680-931 1.2e-31 104.4 In-house 16-261 (281) alignment 
Range on Protein: 680-931
Range on HMM: 16-261/281.0
EFQRLATDRTEpHRFASATKNVNKGKNRFVNIMPYEYNRVKLSF-IRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTK
||  |  |       .   . ||. |||..||   .  ||.| . .   . .||| | || |   .| |. |||| |.|  |||||||. ..  |||| .
efsnlpgdpps.dlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

LEEKQQECSFLYWS-D-LESRQFGEITIELIKKKEEIDYLHRQFKIAHleQPEaSYTLHHFQFLGWPERGVPVSALPLLQMIQNvqelyITLRTTEPItV
. | ..|    |.  .     || .....      .   .  ......  . | .  . |. .  ||.  || |.  .|.....     |  |.| |. .
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy..ege.trlithwlwkewpdwqvpessevmlkilrk.....irarstppv.i

MCSSGVGRTGVFIALGIVLERY-SVEGMIDLFQTVKTLRIQ-RSAMVQTrLSQKKIV
 ||.||||.| ..|. | |.   |   . |. | |  ||.  |.| ||| | |  ..
hcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqt.lqqymli
0046846 (Phosphotyrosine protein) phosphatases II 728-924 3e-31 103.9 In-house 10-159 (176) alignment 
Range on Protein: 728-924
Range on HMM: 10-159/176.0
EGSDYINASYIDSYRqqraYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESRQFgeitielikkkeeidylhrqfkiahleq
...|||||..|...|    ..|||||. .|..||..|..|.. ...|.||.. |...   . ||..||. ..                            
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

peasytlhHFQFLGWPERGVPVSalplLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLErysvEGMIDLFQTVKTLRIQRS-AMVQTR
        ....|.||. ||| .     .... .....  |.  .|. | || |.||||...|. ..      |  ..........| ||.  .|||.
........qylhlpwpDhgvpdl....elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 512-682 5e-30 99.2 In-house 68-230 (440) alignment 
Range on Protein: 512-682
Range on HMM: 68-230/440.0
LVECVPLANYTFRTFtiMKGGTSkdlREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLppDTGPMIVHCSAGVGRTGTFVVIDSMLQRIlHGEDN
 |. || ..|   ..  ..|  |   | ..|.|. .|||.|||.|   .| ||. |   ...     ||..||||||.||||  ...||.|.   .  |.
evkgvpdsdyinasy..ingies...rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka..gngpllvhcsagagrtgviiavdsilrea.krsdq

VDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACGVTDVTSDQFPVHLDKLELIQEDGESSLLEMEFQ
.||.  .  .||.|  |||| .|| |.|||. |.. || | .  |.   ......  .   . | |. ||.
idifsfinsmrnnrpqmvqtpeqyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 408-645 6.2e-30 99.0 In-house 45-275 (312) alignment 
Range on Protein: 408-645
Range on HMM: 45-275/312.0
AKNRYDNILPYDHTRVKLSTvkwqEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPT-----DVNER
  ||| ||  .|  |  |.     .   || | |.    ||.....||||. .|.  ||...    |..|.... . | .. ||  |        |... 
dlnrypniqcwdrgrftlag....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

CTYGGvEVTLVEC--VPLANYTFRTFTIMKGGTSKDLrEVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAhhnrlppDTGPMIVHCSAGVGRTGTFVVIDS
  |    .| .|       . | | . ..   | ..   . .. ...|||||.|.   . | .. .|.        |  |.| |||||||||||...|.|
rvyte.ycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrllsavkk.......dkkpviahcsagvgrtgtlalies

MLQRILHGEDnVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
|.  . |     ..     |||..|   |..  || .   .. | 
miaalrhprk.qnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_CG42327_pd Subfamily CG42327 384-569 8.2e-30 98.5 In-house 8-192 (319) alignment 
Range on Protein: 384-569
Range on HMM: 8-192/319.0
MEEFGTIPMNPGHPKEVANyECNlAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMK-PQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTK
.|||  .|    .  ||    ..  |.|. |..|  .||| |  .  .. . |..||.. |. . | .|||.| .. ..  .|||.||||.| .|| .|.
aeefrdlPqliaradevPv.tsk.dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LQEKSTVKCDCYWPTDV--NERCTYGGVEVTLVECVPLANYTFRTFTImKGGTSKDLREVRQFHFtAWPDHGVPEFPTSMLSMIRCVRA
|.|.   .|  |.||    ... .|| . ||| .     .|   |. . |    .  ||.  . .  |.. .||  ......|.  ||.
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll.krvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_egg_pd Subfamily egg 403-643 2.2e-29 97.1 In-house 37-267 (307) alignment 
Range on Protein: 403-643
Range on HMM: 37-267/307.0
YECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKstVKCDCYWPTDVNER
 . || | |   .   | .||||   . |   |.| |  ..|     ..| .| |. .|  .|||||....   |||.|  .|    .|. |||   .. 
sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

CTY--GGVEVTLVECVPLANYTFRTFTIMKGGTSkdlREVRqfHFTAWpdHGVPEFPTSMLSMIRCVRAHHNRlppdTGPMIVHCSAGVGRTGTFVVIDS
  .  |..... ..    |.  ||   .   |.    .| |  .   |   |  .. . . | .| .|   |     . |..|..  || ...|.| |. 
lvtvpGslrienlkvdskadplfrvtklklvGgd...deer..flehw..qgdvnnssdvysplrvlrklrnl....skpvvvqdilGvskaatlvaiei

MLQRILHGED-NVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
 |  .| |      .   | .|| .|.. |..  .|.|..  . 
allsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 676-925 3.6e-29 96.7 In-house 17-264 (307) alignment 
Range on Protein: 676-925
Range on HMM: 17-264/307.0
LLEMEFQRLATdrTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRAteGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVM
 |  ||. ||    .|.  .  . . |  |||. ..   . .|. . |  .   |||| | |.    . . ....|||..||. .|| |. ..| . ..|
alvdefrvlak..ktpegvtveafsantdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim

LTKLEEKQQECSFLYWSDLESR--QFGE----ITIE-LIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyitl
| |. |  .     ||   | .   |||    |... |  ||   |    .    ...  . | |..|.|.  ||.||||   |  . ... |.      
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry.....

rTTEPITVMCSSGVGRTGVFIALGIVLERY-SVEGMIDLFQTVKTLRIQRSAMVQTRL
  |.|. | ||.||||.|  .|. .| ..  . .   |. . |. || ||   .|| .
.dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqtea
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 733-924 4.2e-29 96.2 In-house 78-267 (301) alignment 
Range on Protein: 733-924
Range on HMM: 78-267/301.0
INASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLES--RQFGEITIELIKKKEEI--DYLHRQFKIAHLEQP
| | .|..  . . ..|||||.||| |||| |.  .. . ||||..  ||..|    | .   |   . |  .|.. .|.  .  .  .|.....   . 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

EASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQelyitlRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 |. |. |.|.  |..|||| |   | .... |.      .. .|| | ||.|.||.  ||.  ..  .   .  |.| ...| || .|   |||.
fatrtvthyqysewtdrgvPkshaelfdlmelvk......ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 409-638 1.3e-28 94.7 In-house 53-273 (301) alignment 
Range on Protein: 409-638
Range on HMM: 53-273/301.0
KNRYDNILPYDHTRVKLSTvkwqEG-SDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGG
|.||...    .| |.. .    .|    | | ...   .|...||||||. .|  .|| |.   .  .|||...  || . ||. | |....|.   | 
khryptvPckPstaveviv....dGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

VEVTLVECVP--LANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrlppdtgPMIVHCSAGVGRTGTFVVIDsMLQRI
 ......       . . ||. .       . | |  . .. |.|.|||.  . .  ..  |.  ..       |..||||||.||. .|.  . .| | 
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigte.ylare

LHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFI
.. . ....   .  ||..|   |||. | ...
veadptieltealkhlrehrwngvqtnsqlywm
0048076 (Phosphotyrosine protein) phosphatases II 494-642 5.3e-28 92.9 In-house 2-139 (145) alignment 
Range on Protein: 494-642
Range on HMM: 2-139/145.0
YWPTDVNERCTYGGVEvTLVECVPLANYTFRTFTIMKGGTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRlppdTGPMIVHCSAGVGRTG
|||. . ..  .|..  | ..   |... ..|   .   ..   |.. |.... |||||||...  .|.... .......     ||..|||||||||||
ywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke....ggpvlVHCsaGvgRtg

TFVVIDSMLQrilhgeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
|.|... ||.       .|...  . |.|.|| ..|....|. |..|..
tlvaaylmll......lgvsleealelvrsqrpgavpnpgqlrflyefe
0051082 (Phosphotyrosine protein) phosphatases II 729-925 6.2e-28 92.7 In-house 2-140 (151) alignment 
Range on Protein: 729-925
Range on HMM: 2-140/151.0
GSDYINASYIDSYrqqraYLATQGPMKntveDFWRMIWEHKSKIIVMLTKLEEKQqeCSFLYWSDLEsrqfgeitielikkkeeidylhrqfkiahleqp
 |||||.||....     .....||.     ||.....|.. | ||.|...|| .      |. .|.                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

easYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyitlRTTEPITVMCSSGVGRTGVFIALGIVLERysvegmIDLFQTVKTLRIQRSAMVQTRL
    ...|...|.||. |.|.|   .|.... ...         |. | ||.|.||||...|| ..|..      ..|..... .|..|  .||.  
...ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 702-925 7.9e-28 92.3 In-house 43-258 (288) alignment 
Range on Protein: 702-925
Range on HMM: 43-258/288.0
NKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL--ESRQF
|  ..|. |.   .. |||||     .   ||.|  . | . .|  . .| |.. |.| .|.|. |   . ||||..| || .| |  |.     |. ..
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVqelyitLRTTEPITVMCSSGVGRTGVFIALGIVLERYS
| .     ||...|| | .   .   .. | .  . .  .| |.. ||| . |. |.... .        ...|| |..| |||||| .|   |.||   
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslr

VEGMIDLFQTVKTLRIQRSAMVQTRL
..  . . . .. || .|   .||  
lddflgirsllaklreerfkaiqtem
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 687-926 8.5e-27 88.6 In-house 40-277 (305) alignment 
Range on Protein: 687-926
Range on HMM: 40-277/305.0
DRTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfirATEGSDYINASYIDSY-RQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQE
| |.    |  . .... |||. ..   . . |||.       |||| | |.      .. ....|||. .|...|| |. ..| . |||| |  |  . 
dmtqvafnanqsadiaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgkl

CSFLYWSDLESRQ---FGEITIELIKKKEEIDYlHRQFKIAHLE--Q-PEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyitlrTTEPITVMCS
    ||      .    . | .| .     ..    . .|. |.     . . .. |.|.  ||.||||   |  |...  ..       .  || | ||
kcaqywpaaqgeklelksgivvenvsgskpmer.daeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg......skvpivvhcs

SGVGRTGVFIALGIVLERYSVEGM-IDLFQTVKTLRIQRSAMVQTRLS
.|.||||  .|.  .||. . .     . . ||.|| ||.  .|. . 
agigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 449-639 1.3e-26 88.0 In-house 5-197 (199) alignment 
Range on Protein: 449-639
Range on HMM: 5-197/199.0
QQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTS-KDLREVRQFHFTA
..||||| |. ||. .||.||||  |  ||||   | .  .    ||||  .    || . ||    .  ..||  .. . .  |.    ||. .. ||.
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEFPTsMLSMIRCVRAHHNRL-PPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGE-DNVDIYGHVTLLRNQRNFMVQTEDQYFFIH
| ..  |.    .. .. . |   ..       |.||||| | | || || .|  ..         ||..     ||. |  .. . ..| ||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 449-639 1.4e-26 87.9 In-house 4-196 (198) alignment 
Range on Protein: 449-639
Range on HMM: 4-196/198.0
QQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTS-KDLREVRQFHFTA
..||||| |. ||. .||.||||  |  ||||   | .  .    ||||  .    || . ||    .  ..||  .. . .  |.    ||. .. ||.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEFPTsMLSMIRCVRAHHNRL-PPDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGE-DNVDIYGHVTLLRNQRNFMVQTEDQYFFIH
| ..  |.    .. .. . |   ..       |.||||| | | || || .|  ..         ||..     ||. |  .. . ..| ||.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
0044763 (Phosphotyrosine protein) phosphatases II 713-927 2e-26 88.2 In-house 1-160 (178) alignment 
Range on Protein: 713-927
Range on HMM: 1-160/178.0
PYEYNRVKLSFIRATEGSDYINASYIDSYrqqrAYLATQGPmkntvEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLESrqfgeitielikkkee
|.. .||.|| .. .|.|||||||.|. .     ||....|     .|......|.. . ||.||.  |  .. .. || . ..                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

idylhrqfkiahleqpeasytlHHFQFLGWPERGVPVSALPLLQMIQNVQELYItlRTTEPITVMCSSGVGRTGVFIALGIVLERysveGMiDLFQTVKT
                       .......|  ||| .   .|.... ..|..   .  .|. | || ||||.|...|. .....    |. .|.. .. 
......................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaiel

LRIQRSaMVQTRLSQ
.| .|. .|...  .
vrerRp.ivpnpgql
subfamily_eak_pd Subfamily eak 405-645 2.4e-26 86.9 In-house 51-304 (332) alignment 
Range on Protein: 405-645
Range on HMM: 51-304/332.0
CNLAKNrYDNILPYDHTRVKLSTVKwQEGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCT
 .. .|   .|.|||.  |.|.. . ..   ||||| ..     ..|| |  .  . .  ||.|| ||.| .||.. .  |.   | | |.| .  |   
eavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

YGGVEVTLVECVPLANYTFRTFTIMKGGTSKdlrEVRQFHFTAWPDHGVPEFPT-----------SMLSM-------IRCVRAHHNRLPPDTGPmIVHCS
.| ..|.  | |  ... .| . . ||  ..   .|  ...  | .  .| .              .| .       .. .  ..   ||   | |. ..
fGildverkefvkrniletrllelskGneth...rvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfap.iiqsa

AGVGRTGTFVVIDSMLQRILHGEDNV-DIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
 |  |.|.||||| ... |     |.  .   .   ...|.  | .. |. ||.|.. . 
rGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 697-926 4.8e-26 86.4 In-house 30-258 (285) alignment 
Range on Protein: 697-926
Range on HMM: 30-258/285.0
ATKNVNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDS-YRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQ-ECSFLYWSDL
.. . |   ||. ..   |  || |         ||| ||..    ..| .|..||||. .|. |||.||.. |   ..||  | |    .|.. |   |
tayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

-ESRQFGEITIELIKKKEEI--DYLHRQFKIAHLEQPEA-SYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYitlRTTEPITVMCSSGVGRTGVFIA
 |  .||.  | | . |||     .   . .   |.  .    . | |   ||..  |  | |.... . |...       .|| | ||.|||||  |. 
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn...pkekpicvhcsagvgrtatfvg

LGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLS
.     |   .  |.... |. .|  |   ||... 
idyatirimenpniemldivremramrfqavqshmq
0048179 (Phosphotyrosine protein) phosphatases II 532-640 8.9e-26 85.7 In-house 41-139 (144) alignment 
Range on Protein: 532-640
Range on HMM: 41-139/144.0
GTSKDLREVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNrlppDTGPMIVHCSAGVGRTGTFVVIDSMLqrilhgEDNVDIYGHVTLLRNQRNFMVQT
      ||. |.... |||||||.... .|.... ......    . ||..||||||||||||.|... |.      . .....  . |.|..| ..|..
epefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpgavpn

EDQYFFIHE
..|. |..|
pgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 700-812 1.4e-25 84.7 In-house 44-168 (350) alignment 
Range on Protein: 700-812
Range on HMM: 44-168/350.0
NVNK-GKNRFVNIMPYEYNRVKLS--------FIRATEGSDYINASYIDSY----RQQRA--YLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQ
 |.   |||..||.||| .||||            .....|||||.|.       ...    |.|||.|...||.||...| . | |.|..||.. | . 
GvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnl

ECSFLYWSDLEsrqFGEITIELIKKKEE
|    || ...   . .||. |  |.|.
ekcyrYWqegs...ydditvklaskwen
subfamily_egg_pd Subfamily egg 690-925 4.9e-25 82.8 In-house 28-257 (307) alignment 
Range on Protein: 690-925
Range on HMM: 28-257/307.0
EPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKqQECSFl
.   .  | .. |. | |   .   .. |||| . |     |.| | ...       .. .| |.||||.|||||... . . |||||   |  ..| . 
deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.ercey.

YW--SDLESRQF--GEITIELIKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFlGWPERGVPVSALPLLQMIQNVqelyitlrtTEPITVMCSSGVGRT
||  .. .| ..  | . || .| ... | | |  |.  .   .    | |.|   . . .   | | .|....|.         ..|. | .  || ..
ywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnl.........skpvvvqdilGvska

GVFIALGIVLERYsVEGMI---DLFQTVKTLRIQRSAMVQTRL
....|. | |  . . | |    . ..|. || .|   |.. |
atlvaieiallsl.lrGpitkslvlravvflrlrrrlsvesvl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 698-924 7.8e-25 82.2 In-house 44-273 (305) alignment 
Range on Protein: 698-924
Range on HMM: 44-273/305.0
TKNVNKGKNRFVNIMPYEYNRVKLsfiRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYW--SDLE
 .  ..||||. ..   . |||||   ...   .|| | |. .  . . .. || |...|  ||| | ...| . | || .| ||  .  . |.   | .
keaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

SRQFGEITIELIKKKEEIDYL-HRQFKIA-------HLEQP-EASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyitlrTTEPITVMCSSGVGRTG
  .| |    .. | |    |  |.   |        .| | | .    |. .  ||.|||| . | .|..... .       .  ||.| ||.|.||||
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp......skgpivvhcsagigrtg

VFIALGIVLERYSVEGMIDLFQ-TVKTLRIQRSAMVQTR
  . |  .|..     .|.  .  .. .| ||   .|| 
svvmleyildqllagqiiedtdkilqkireqrnnsiqtd
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 447-612 8e-25 82.4 In-house 26-185 (255) alignment 
Range on Protein: 447-612
Range on HMM: 26-185/255.0
KPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVEcvPLANYTFRTFTIMKG-GTSKDLREVRQFHF
||..    .   . |. .|....  ... ..||.. ..|.. .||. |.|.. .|.  .  |.||  .  . |.  .|| .|.   |  |  ..|. ...
kPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysy

TAWPDHGVPEFPTSMLSMIRCVRahhnrlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHG---EDNV
. |...  || .  .| ... ||        |. ...||||.|.||. .||..... |....     . |
kGWieknaPelareilnilkvvr........dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 407-497 2.3e-24 80.8 In-house 48-152 (350) alignment 
Range on Protein: 407-497
Range on HMM: 48-152/350.0
LAKNRYDNILPYDHTRVKLS--------TVKWQEGSDYINASFLDGF-----MKPQQ-YIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCD
 ||||| |||||.|.||||           .  ...|||||..|        ..|.  |||||.|. .|. .|.... . .   |...|...|    ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

CYWPT
 ||. 
rYWqe
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 742-922 5e-24 79.6 In-house 2-188 (199) alignment 
Range on Protein: 742-922
Range on HMM: 2-188/199.0
RQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKlEEKQQE-CSFLYWSDLESR--QFGEITIELIKKKEEIDYLHRQFKI-AHLEQPEASYTLHHF
. || |.||| |...|. |||.|.||  |  |||.   ..|..|    .||.  ||   ..| ...       . ||    . .      | ..  . |.
kgqrryiatqhplretmadfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

QFLGWPERGVPVSALPLLQM--IQNVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLE--RYSVEGMIDLFQTVKTLRIQRSAMVQ
||  | |.  |  || .  .   ..|   |       |. | || | | ||||.|| | .     |   ..|||.  | ||  |  .. 
qftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 743-922 6.9e-24 79.1 In-house 2-187 (198) alignment 
Range on Protein: 743-922
Range on HMM: 2-187/198.0
QQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKlEEKQQE-CSFLYWSDLESR--QFGEITIELIKKKEEIDYLHRQFKI-AHLEQPEASYTLHHFQ
 || |.||| |...|. |||.|.||  |  |||.   ..|..|    .||.  ||   ..| ...       . ||    . .      | ..  . |.|
gqrryiatqhplretladfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FLGWPERGVPVSALPLLQM--IQNVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLE--RYSVEGMIDLFQTVKTLRIQRSAMVQ
|  | |.  |  || .  .   ..|   |       |. | || | | ||||.|| | .     |   ..|||.  | ||  |  .. 
ftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 684-936 7.9e-24 78.8 In-house 36-287 (310) alignment 
Range on Protein: 684-936
Range on HMM: 36-287/310.0
LATDRTEPHRFASATKNVNkgKNRFVNIMPYEYNRVKLSFIRaTEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQ
| ...     . . .|..   |||. ...  .  ||||   . .   ||| | |. .   . ... .|||.. |. ||||||.. ... |..| |  |. 
ldakqdssltyeaykkymh..knrysdvvcldtsrvklkidk.sryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeeg

QECSFLYWSDLES-RQFGEITIELIK-KKE--EIDYLHRQFK---IAHLEQPEASYTL--HHFQFLGWPERGVPVSAlpllqMIQNVQELYITLRTtEPI
.  .  ||  |     .| | .  .    |  ||  |   |    .   |||     |     ..  ||.||||             | |   .|   | 
rpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek.....chtvpqrllaqvrh.gpc

TVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRLsQKKIVLSLKM
 | ||.|..|..| .|| . ...      .|. . .  |. .|   .|| | |  |.  ...
vvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtel.qyliidrvri
subfamily_CG42327_pd Subfamily CG42327 702-862 1e-23 78.6 In-house 28-191 (319) alignment 
Range on Protein: 702-862
Range on HMM: 28-191/319.0
NKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDSYRQQR-AYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDLE----S
 | |.|..|..|    || |  |   . . |..|||.  |.. .  |.|.| .....  ||||..|| .|..|| ||.| |.  .    |.   |     
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

RQFGEITIELIKKKEEIDYLHRQFKIAHLEQpEASYTLHHFQFlGWPERGVPVSALPLLQMIQNVQ
. .|.| . | ... .  |.   . . .... | |  | |. .  |.| .|| .  .|. |. .|.
slyGdilvtlkgrevkdryaistlllkrvdk.eesrelthywy.kwleaevPaeeaaliamllevr
PTPc_DSPc_SM00012 833-924 1.2e-23 78.7 In-house 1-93 (105) alignment 
Range on Protein: 833-924
Range on HMM: 1-93/105.0
TLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVE-GMIDLFQTVKTLRIQRSAMVQTR
|..|....|||. ||| .. ..|.....|.. .    ...|. |.|| ||||||.|.|| |.|.. . | . .|.||.|| || ||. |||| 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 362-456 2.2e-22 73.1 In-house 4-95 (95) alignment 
Range on Protein: 362-456
Range on HMM: 4-95/95.0
TIHNYQFPAHLAVMRMNDNQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKwqeGSDYINASFLDGFMKPQQYIATQG
 ||   | .|.  |  | .| | .|| .|.|  | |  |   |.|. |||. ||.||| ||| |.| .    |||||| |.||. . . |||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 410-642 3.5e-22 73.9 In-house 23-255 (290) alignment 
Range on Protein: 410-642
Range on HMM: 23-255/290.0
NRYDNILpYDHTRVKLSTVKWQEGSDYINASFLDgFMKPQQYIATQGPMAET-------IGEFWRMVWEQNSATIVMVTKLQEKSTV----KCDCYWPTD
.|... |   .||| |   . .  .||| |...  . . .. |.|| | ...       | .|| |. . ..  .||. . .|||.      |  | |. 
qRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

VNERCTYGGVEVTLVECVPLANYTFRTFTIMKGGTsKDLrEVRQFHFTAWPDHGVPEFPTSMLSMIRCVRAHhnrlppdTGPMIVHCSAGVGRTGTFVVI
|.|  ...|..|   . .   .   |. ..  ..  ...  |    .  | .  |.| . ..||.|. |.|.       . |.||||  |. |  ..  |
vgeelkfkgltvkCkskekeddvetRelvvkfdde.eef.tvtHsllkgWnklnvqedtktllsliqkvkas.......ktpvivHcvdGiSrsAalaai

DSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAI
.   | | . ...| .   .  ||.||. ..... .. |.  .|
ilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 455-645 4e-22 73.0 In-house 97-287 (302) alignment 
Range on Protein: 455-645
Range on HMM: 97-287/302.0
QGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVEC-VPLANYT----FRTFTIMKGG---TSKDLREVRQFHFT
  |  .|.  .| .. . | | .| .... |.   ||  |. ..|... ..|   |. |.    |...|    |. .|.       ..|  . |  ..|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPDHGVPEFPTSMLSMIRCVRAHHNRlppdtgpMIVHCSAGVGRTGTFVVIDSMLQRILHgEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEA
|||||| |. . . | ...   .. .        ..||||||||||||.| |   .|  .. ..  |.   |. .|. |   ||.|.|  ..   .  .
awpdhGapkeaytaldilkfcesykkn.......vlvhcsaGvGrtGtlvaikyGiqlcsk.kkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_hpo-7_pd Subfamily hpo-7 458-611 9.7e-21 68.8 In-house 43-190 (263) alignment 
Range on Protein: 458-611
Range on HMM: 43-190/263.0
MAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNERCTYGGVEVTLVECVPlaNYTFRTFTIMK-GGTSKDLREVRQFHFTAWPDHGVPEF
. .|| .|....  ... ..||..  .|.. .||. |.|.. .|.  .  |.|.  . .   .   .|  ...  |  | ...|... .. |...  || 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PTSMLSMIRCVRAHHnrlppdtgPMIVHCSAGVGRTGTFVVIDSMLQRILHG---EDN
. ..| ... .|  .        ...||||.|.||.  |.|.... |....     . 
areilnilkvarnsk........slvvhcstGiGrsaafsvaElvyqkmirsldttst
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 701-934 4.2e-20 66.5 In-house 46-274 (303) alignment 
Range on Protein: 701-934
Range on HMM: 46-274/303.0
VNKGKNRFVNIMPYEYNRVKLSfirateGSDYINASYIDSYRQQRAYLaTQGPMKNTVEDFWRMIWEHKSKII-VMLTKLEEKQQECSFLYWSDLESRQF
 |  |||||...  .. .||||       | || |||..   ...| | || |.  |  |||.|| | | | . ..||  | ..    ...  . .  .|
knmdknrfvdvicldhskvkls......dssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GEITIELIKKK-EEIDYlHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVSALP-LLQMIQNVQELYITLRTTEPITVMCSSGVGRTGVFIALGI-VLE
 | .| . . |  |.     ..|.  . . .    ||  ..  ||   .|  . | ... | ..| .      ..|   |  ||.||.| |  .    | 
eersirvgefkrvelgd.gwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

RYSVEGMIDLFQTVKTLRIQRSAMVQTrLSQKKIVLSL
 .| .  .|| . ....|  |   ||  |||  .| .|
lhseqasldlvkclenvrngrlhavqn.lsqfsvvytl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 382-647 2.8e-18 60.4 In-house 27-286 (302) alignment 
Range on Protein: 382-647
Range on HMM: 27-286/302.0
RFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTvkwqEGSDYINASFLDGFMKPQQYIATQGPMAETI---GEFWRMVWEQNSATIV
.  .|| .|     .  .   .  ||.||. ...  .|...|||..    |  .|.||| ..     .. | .| |  ..     ||||||.... ...|
evkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv

MVTKLQEKSTvKCDCYWPTDVNERCTYGGVEVTL--VECVPLANYTFrTFTIMKGGTSK-DLREVRqfHFTAWPDHGVPEFPTSMLSMIRCVraHHNRLP
.. . .| ..   . ..|.  ..  .|| . |    || .  ... . .  ..  | |   | .|   ..| |... ||.  ...   .  |  ...  .
ilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektry.viEvlPegcsnsvlanvy..vltnWkqkkvpvkyaeliktaakv..fakkik

PDTgPMIVHCSAGVGRTGTFVVIDSMLQRILHGeDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIA
 |  ....    |.|| |.|..    .... .| ... |   |. .|.||  .|.. .|| ... |..  | 
ade.ntvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 715-924 4.1e-18 60.5 In-house 31-245 (290) alignment 
Range on Protein: 715-924
Range on HMM: 31-245/290.0
EYNRVKLSFIRATEGSDYINASYIDsYRQQRAYLATQGPMKN-------TVEDFWRMIWEHKSKIIVMLTKLEEKQQE-----CSFLYWSDL-ESRQFGE
| .|| |        .||| |...  . .  . ..|| | ..       |.|.|| |. . |.| .||| . |||...     |.  .     |. .|. 
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

ITIELIKKKEEIDYLHRQFKIAHLEQPEasYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyitlrTTEPITVMCSSGVGRTGVFIALGIVLERYS-V
.|..  .| .| |  .|.  . . .. |  .|. | .. || .. |. . . ||..||.|.        . |. | |  |. |  .. |. .        
ltvkCkskekeddvetRelvvkfddeee..ftvtHsllkgWnklnvqedtktllsliqkvka......sktpvivHcvdGiSrsAalaaiilgyQkiaet

EGMIDLFQTVKTLRIQRSAMVQTR
.| . | . .|.|| ||  .... 
sgsvkledvlkalrkqralaitsa
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 402-647 4.2e-18 60.0 In-house 43-280 (303) alignment 
Range on Protein: 402-647
Range on HMM: 43-280/303.0
NYECNLAKNRYDNILPYDHTRVKLSTvkwqegSDYINASFLDgFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVKCDCYWPTDVNE
..  |. |||. ...  ||..||||       | || ||.|. .   .. | || |.. |  .||.|. ||.   ....    |  ..  |  .| . . 
qfvknmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf

-RCTYGGVEVTLVECVPLAN-YTFRTFTImKGGTSKDLREVrqFHFTAWPDHGVPEF-PTSMLSMIRCVRAHHNRLPPDTgPMIVHCSAGVGRTGTFVVI
 .     . |     | |.. ....  ..   |. | .  |   |. |||   .|      ..  |  ...   .  . | | .    .|.||.||| ..
lkfeersirvgefkrvelgdgwvlkvlsv.sngdyksflhv..hhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfalf

DSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIA
..    .   .  .|.   .  .|| |   ||   |. ...  . | . 
etahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 673-923 1.2e-17 58.2 In-house 24-270 (302) alignment 
Range on Protein: 673-923
Range on HMM: 24-270/302.0
ESSLLEMEFQRLATDRTEPHRfASATKNvNKGKNRFVNIMPYEYNRVKLSfiraTEGSDYINASYIDSYRQQRAYLATQGPMKNTV---EDFWRMIWEHK
... .. ||....| ...  .  .| |. |  ||.  ..  .. |.|||.    .|  .|.||| ..    .|  . .| | ....   |.||||....|
dtaevkkefkkidtmkvdlek.Ckafkk.nlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqek

SKIIVMLTKLEEKQQECSFLYWSDLE-SRQFGEITIELiKKKEEIDYLHRQFKIAHLEQPEASYTLHHFQF-LGWPERGVPVSALPLLQMIQNVqeLYIT
 . .|.| . || ..  | |.    .   ..|.. .   .| |. .  . .. |  | .  .   |   .    |..  |||.   | . ...|     .
ivsvvilvgeeelkktlselfpkksgdykeygkmfvNn.rkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakk

LRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQT
  ..|.. ..   |.|| |.|..| ...|.   .      ..||..| ||...|..
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravds
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 581-649 1.4e-17 57.9 In-house 1-68 (69) alignment 
Range on Protein: 581-649
Range on HMM: 1-68/69.0
MIVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACG
|.||||.| ||||||. |   . ||   |  |||.  |  .|  |  ||  | .| |||.|. ||.  |
mvvhcssgtgrtgtfiaimvemari.kseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 703-892 1.4e-17 58.3 In-house 44-230 (312) alignment 
Range on Protein: 703-892
Range on HMM: 44-230/312.0
KGKNRFVNIMPYEYNRvklsFIRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL------E-
|  ||. ||  ..  |    |  | .   || | ..    .   ...||||..||.  ||..     |  |..|. . |   | .  | ||.      | 
kdlnrypniqcwdrgr....ftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

SRQFGEITIEL-IKKKEEIDYLHRQFKIAHLEQPEASyTLHHFQFLGWPERGVPVSALPLLQMIQNVQelyitlRTTEPITVMCSSGVGRTGVFIALG
 | . |   |. |  |      || .|.      . |  | |.|.  ||. |.| |    |...  |.      .   |.   ||.|||||| .. . 
hrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrllsavk......kdkkpviahcsagvgrtgtlalie
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 537-642 2.3e-17 57.8 In-house 214-340 (350) alignment 
Range on Protein: 537-642
Range on HMM: 214-340/350.0
LREVRQFHFTAWPDHGVPEFPTSMLSMIRC-------VRAHHNRLPPDTGPMIVHCSAGVGRTGTFVVIDSMLQ--RILH----GEDNVD--------IY
  .| |...  |.| ..   | |.|... .         |.       . |..||||||||||||.| .||.|.   ||.       ..|        | 
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

GHVTLLRNQRNFMVQTEDQYFFIHEAI
  |  ||.||  |||. ||. ||.||.
iivnelrkqrismvqnldqfifiYeal
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 751-925 2.3e-17 57.4 In-house 97-275 (302) alignment 
Range on Protein: 751-925
Range on HMM: 97-275/302.0
QGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQECSFLYWSDL--ESRQFGEITIELIKKKEEIDYL--HRQFKIAHLEQ------PEASYTLHHFQFL
  | |.|.| .| .| ...  |.| |... |....    |.||   .  .||. |.. .. |.... .   ..||.  .|        .  .|.. ..| 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

GWPERGVPVSALPLLQMIQNVqELYitlRTtePITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTRL
.||. | |  | . |....   | |   ..   . | || |||||| ..|.   ..  | . . || . |. .|  |   ||.  
awpdhGapkeaytaldilkfc.esy...kk..nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 688-846 2.8e-17 57.1 In-house 82-234 (244) alignment 
Range on Protein: 688-846
Range on HMM: 82-234/244.0
RTEPHRFASATKNVNKGKNRFVNIMPYEYNRVKLSfiRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQecs
| .|  .  | .  |  |||    .|...||| ||  ... |  |||||..    .   |. || |. .|  |||.|. | . ...|.|  .||...   
rpdpsvmkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede...

flYWSDLESRQFGE--ITIELIKKKEEIDYLHRQFKIaHLEQPEASYTLHHFQFLGWPERG
  || | |  .. |  ||. |  . |  .    ...|   .  |.  .|  ||   ||  |
..ywpdseplewyeeditvtltdrdefknikasnlei.esdmneshqaltmfqisnwpsdg
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 582-649 4.2e-17 56.3 In-house 1-67 (69) alignment 
Range on Protein: 582-649
Range on HMM: 1-67/69.0
IVHCSAGVGRTGTFVVIDSMLQRIlHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAINEAIACG
.||||.| ||||||. |   . ||   |  |||.  |  .|  |  ||  |..| |||.|. ||.  |
vvhcssGtGrtGtfiaimvemari.kseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 830-924 1.3e-16 55.0 In-house 87-180 (440) alignment 
Range on Protein: 830-924
Range on HMM: 87-180/440.0
ASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELYITlRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQTR
 | ||..... |||..|||  | |.|.|||.|.|         |. | ||.|.||||| ||.  .|        ||.|  ....| .|  |||| 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek.agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp
subfamily_eak_pd Subfamily eak 687-850 1.6e-16 54.7 In-house 36-197 (332) alignment 
Range on Protein: 687-850
Range on HMM: 36-197/332.0
DRTEPHRFASATKNVNKGK-NrFVNIMPYEYNRVKLSFIRAtEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQE
|. .. .  | |. ... . |  |.|.||... |.|.  .  .   ||||| ..     | |. |  . .. |  ||.|. | ||  ||.| .  |.. |
ddyqrllsisetarleavnrn.vvkivpydrylvrltssql.nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkle

CSFLYWSDLE--SRQFGEITIElikKKEEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERGVPVS
 |  |. |      .|| . .|   .|| .     ...   |.. . .. ..|... || |  .|. 
ksdkyfpdktreelkfGildve...rkefvkrniletrllelskGnethrvlhykvfGwtettlpky
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 753-943 8.8e-16 52.7 In-house 39-217 (255) alignment 
Range on Protein: 753-943
Range on HMM: 39-217/255.0
PmknTVEDFWRMIWEHKSKIIVMLTKLEE-KQQECSFLYWSDLESR-QFGEITIELIKkkEEIDYLHRQFKI-AHLEQPEASYTLHHFQFLGWPERGVPV
    ||. |...|   |.. .|||. ..| ....||  .  ... . .. ....   |     | . |  .| ..| .     |..|... ||.|.  | 
l...tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPe

SAlpllqmiQNVQELYITLRTTEPITVMCSSGVGRTGVFIalgivLERYSVEGMIDLFQTVKTLRIQRSAMV-QTRLSQKK-IVLSLKMTYSFFTL
 |       .......   | . .. |.||.|.||.  |.     |  .    ||  ..| .|  ..   .. ..| ..|. |   |....|....
la.......reilnilkvvrdsksvvvhCstGiGrsaafv.....laelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 407-497 5.1e-15 49.6 In-house 49-155 (349) alignment 
Range on Protein: 407-497
Range on HMM: 49-155/349.0
LAKNRYDNILPYDHTRVKLST--------------VKWQEGSDYINASFLD--GFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKSTVK
 ||||| .||||.|.||||                 .     ||||| .|    .   ..||||| |.  |. .|....  ..   .. ... .|.|  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CDCYWPT
|| ||  
cdiywqe
subfamily_CG42327_pd Subfamily CG42327 577-643 8.6e-15 49.2 In-house 246-312 (319) alignment 
Range on Protein: 577-643
Range on HMM: 246-312/319.0
DTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNVDIYGHVTLLRNQRNFMVQTEDQYFFIHEAIN
. ||..|||| ||||||. .  |  .... . .  |||   |  .|..|   |.| .|| ||.  . 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 698-806 2e-14 47.7 In-house 43-165 (349) alignment 
Range on Protein: 698-806
Range on HMM: 43-165/349.0
TKNVNK-GKNRFVNIMPYEYNRVKLSF-------IRA-------TEGSDYINASYIDS--YRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLE
.. |.   |||. .|.|||. ||||         |.|       .   ||||| |.    .  .. |.||| |.  ||.||...|   . |... |.. .
seGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddk

EKQQECSFLYWSDLEsrqFGEITIEL
|.. |    || .|.   . .||. |
elslekcdiywqels...ysnitvkl
0048076 (Phosphotyrosine protein) phosphatases II 824-924 3.2e-14 48.3 In-house 37-129 (145) alignment 
Range on Protein: 824-924
Range on HMM: 37-129/145.0
HLEQPEASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQElyiTLRTTEPITVMCSSGVGRTGVFIALGIVLErysvEGmIDLFQTVKTLRIQRSAMVQT
  |..  . .  ....|.|| .||| ..  ||.... ..|    |.  .|. | || ||||||...|. ..|.    .| ..|..... .| ||. .|..
tselellerlgiqylylpwpDhgvpdllellleflefiee...alkeggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpn

R
 
p
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 712-846 5.9e-14 46.5 In-house 3-125 (130) alignment 
Range on Protein: 712-846
Range on HMM: 3-125/130.0
MPYEYNRVKlsfirateGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQQecsflYWSDLESRQFGEITIEL-IKKK
...|..|..        | .|||||..    . . || || |. .|  |||.|. |    ..|.|  .||...     || | |  .. |  | . . ..
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdr

EEIDYLHRQFKIAHLEQPEASYTLHHFQFLGWPERG
.| .... ..   . .  |.  .|  ||   ||  |
defknikasnleiesdlneshqaltmfqisnwpsdg
0048179 (Phosphotyrosine protein) phosphatases II 829-924 6.7e-14 47.3 In-house 44-131 (144) alignment 
Range on Protein: 829-924
Range on HMM: 44-131/144.0
EASYTLHHFQFLGWPERGVPVSALPLLQMIQNVQELyitLRTTEPITVMCSSGVGRTGVFIALGIVLerysVEGmIDLFQTVKTLRIQRSAMVQTR
.   . .....|.|| .||| ..  ||.... ..|.   |.  .|. | || ||||||...|. ...    ..| ..|..... .| .|. .|...
fleregiqylhlpwpDhgvpdllellleflefieea...leeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnp
subfamily_hpo-7_pd Subfamily hpo-7 754-943 1.5e-13 45.2 In-house 43-223 (263) alignment 
Range on Protein: 754-943
Range on HMM: 43-223/263.0
MKNTVEDFWRMIWEHKSKIIVMLTKLEEK-QQECSFLYWSDLESR-QFGEITIELIKKKEeiDYLHRQFKIAH-LEQPEASYTLHHFQFLGWPERGVPVS
. .|.. |...|   |.. .|||.  .|. ...||  .  ... . .. ....   | ..  | | .  ..   |..     |..|... ||.|.  |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

ALPLLQMIQNVqelyitlRTTEPITVMCSSGVGRTGVFIALGIVLERysvegMIDLFQTVKTLRIQR-SAMVQTRLSQKK-IVLSLKMTYSFFTL
|   |.... .       |   .. |.||.|.||.  |    .|  .     ||  ..| .|  ..  | . ..| |.|. |   ... .|....
areilnilkva.......rnskslvvhcstGiGrsaafsvaElvyqk.....mirsldttstveldylsLleelrssrkraihtPmqLafsilmv
HTH_3 Helix-turn-helix 116-160 7.1e-13 34.8 Pfam-A 4-48 (55) alignment 
Range on Protein: 116-160
Range on HMM: 4-48/55.0
SRSKAKLSQKDLAARINEKSQVISDYEQGKAIPNAGVLKKMERAL
 | ...|||..||.... . . ||..| |...|.  .|||...||
lRkqlglsqeeLAeklGvsrstisriEnGernPsletlkklakaL
dsrm Double-stranded RNA binding motif 5-70 2.6e-12 33.7 Pfam-A 1-67 (67) alignment 
Range on Protein: 5-70
Range on HMM: 1-67/67.0
PISKLQEITQSWKLAIPSY--RESDGTY--QLFGCEVTInlEGETIAfSALGRNKKESKAKAAEKALEYI
|.|||||. |  .  .. .   |  ..   . | ..|..  .|.... .. |..|||.. .||||||...
pkskLqelcqkkgkppnyeyvseegpphslkkFtvtvkv..ngklyg.tGvgssKKeAeqlAAekALqkL
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 679-752 3.7e-12 40.3 In-house 27-95 (95) alignment 
Range on Protein: 679-752
Range on HMM: 27-95/95.0
MEFQRLATDRTEPHRFASatKNVNKGKNRFVNIMPYEYNRVKLSFIRateGSDYINASYIDSYRQQRAYLATQG
 ||. ..     |.   |   . |  ||||.||.||.  || |.  |    |||||| ..| | .. .|.|.||
nefksismtsgapytvgs..seanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 397-491 5.5e-12 39.8 In-house 25-118 (332) alignment 
Range on Protein: 397-491
Range on HMM: 25-118/332.0
PKEVANYECNLAKNRYDNILPYDHTRVKLSTvkwQEG-SDYINASFLDGFMKPQQYIATQGPMAE-TIGEFWRMVWEQNSATIVMVTKLQEKSTVKC
|.   ..  |.  ||   .  .||.||.|.    |.|  |. |||..||. |   || .| |. . |   ||||| |.. . |...  ..||   |.
pntydkflnnmdmnriphlycfdhsrvelap...qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 380-445 9.2e-12 39.0 In-house 21-86 (440) alignment 
Range on Protein: 380-445
Range on HMM: 21-86/440.0
NQRFMEEFGTIPMNPGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINASFLDGF
 . | .|.  .|    .| ..|.   |  |||| ||| |||.|| |  ||    |||||||...| 
srafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 702-788 1.7e-11 38.2 In-house 34-119 (332) alignment 
Range on Protein: 702-788
Range on HMM: 34-119/332.0
NKGKNRFVNIMPYEYNRVKLSFIraTEGSDYINASYIDSYRQQRAYLATQGPMKNTVED-FWRMIWEHKSKIIVMLTKLEEKQQECSF
|   ||   .  ....||.|.        |. |||..| | .. ||. .| |...  |  ||||. |.|  .|...  ..|||.  . 
nmdmnriphlycfdhsrvelapq..dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 400-487 5.1e-11 35.8 In-house 21-81 (169) alignment 
Range on Protein: 400-487
Range on HMM: 21-81/169.0
VANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINAsfldgfmkpqqyiatqgpmaetigefwRMVWEQNSATIVMVTKLQEKS
.|.  || .|||    |   ||||||  |  . |||||||                           ||.|| |.. ||..   ..| 
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 400-487 6.1e-11 35.4 In-house 20-80 (169) alignment 
Range on Protein: 400-487
Range on HMM: 20-80/169.0
VANYECNLAKNRYDNILPYDHTRVKLSTVKWQEGSDYINAsfldgfmkpqqyiatqgpmaetigefwRMVWEQNSATIVMVTKLQEKS
.|.  || .|||    |   ||||||  |  . |||||||                           ||.|| |.. ||..   ..| 
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn
HTH_31 Helix-turn-helix domain 109-160 1.2e-10 28.0 Pfam-A 2-54 (64) alignment 
Range on Protein: 109-160
Range on HMM: 2-54/64.0
MGRLIQQSRSKAKLSQKDLAARINEKSQVISDYEQGKA-IPNAGVLKKMERAL
 |..... |  |.|||...|.|..     .|..|||.  .| ..|| .. |||
LGarLralReraGLsqeevAeragvSastlsriEqGrrgrpslavlaalaral
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 539-641 2.7e-10 34.1 In-house 219-339 (349) alignment 
Range on Protein: 539-641
Range on HMM: 219-339/349.0
EVRQFHFTAWPDHGVPEFPTSMLSMIRCVRA----HH--NRL-PPDTGPMIVHCSAGVGRTGTFVVIDSMLQrILH---GE--------DNVD-IYGHVT
|. |. .  |.| ..   | |.|  . .        .  . |   .. ...|||||| ||||..| .|..|. ||.    |           | |.  | 
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls.ileplqnesnkiklqallkDlisiivn

LLRNQRNFMVQTEDQYFFIHEA
 || ||  |||   |. .|.||
elrkqrismvqnlaqfiaiyea
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 443-507 3e-10 34.0 In-house 230-290 (440) alignment 
Range on Protein: 443-507
Range on HMM: 230-290/440.0
DGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKStvkCDCYWPtdVNER-CTYGG
.|. | . .|||| |.  |. .|||.| . . .||.|. .|..|.   |  |||  || |  |.| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywp..vntrsvtfgp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 739-805 5.1e-10 33.3 In-house 230-294 (440) alignment 
Range on Protein: 739-805
Range on HMM: 230-294/440.0
DSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVMLTKLEEKQqeCSFLYWSDLESRQFGEITIE
. | .. |..||| |.  || ||||.. ...   |.|| .|..|   ||  .  .  |  || .|. 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt..csiywpvntrsvtfgpftvg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 831-923 6.5e-10 33.2 In-house 214-329 (350) alignment 
Range on Protein: 831-923
Range on HMM: 214-329/350.0
SYTLHHFQFLGWPERGV---PVSALPLLQ----MI-QNVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLERYSVEGM--------------ID-LF
 | ....|.  |.. ..   | | |. |.    .| ... |...    ..|| | ||.||||||....|  .|. . .  .               | ..
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

QTVKTLRIQRSAMVQT
..|. || ||  |||.
iivnelrkqrismvqn
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 401-483 1.1e-09 32.3 In-house 32-119 (347) alignment 
Range on Protein: 401-483
Range on HMM: 32-119/347.0
ANYECNLAKNRYDNILPYDHTRVKLSTVKWQEG-----SDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKL
...| .|.|||  .    | ||| ||  | . .       ||||| .      ..|| || |. .|. .||.||   . . .| . . 
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 374-444 1.5e-09 31.9 In-house 6-76 (244) alignment 
Range on Protein: 374-444
Range on HMM: 6-76/244.0
VMRMNDNQRFMEEFGTIPMN-PGHPKEVANYECNLAKNRYDNILPYDHTRVKLSTVKwQEGSDYINASFLDG
| |..|..   |||  .  .     .  |   .| .|||| ||||.|.||| ||. | .||||||||....|
vsrlqdeevakeefvglsdhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 691-776 2.5e-09 31.1 In-house 26-116 (347) alignment 
Range on Protein: 691-776
Range on HMM: 26-116/347.0
PHRFASATKNVNKGKNRFVNIMPYEYNRVKLSF-----IRATEGSDYINASYIDSYRQQRAYLATQGPMKNTVEDFWRMIWEHKSKIIVML
| .|.|.  . .  |||  .    .  || ||       || .   |||||.|     .. |. || |. .|| |||.|.   |   .| .
pskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 875-922 3.1e-09 31.1 In-house 2-49 (69) alignment 
Range on Protein: 875-922
Range on HMM: 2-49/69.0
TVMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQ
 | |||| |||| |||. . . |   | ..|.|  |. .|  |  || 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvm
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 876-922 3.8e-09 30.8 In-house 2-48 (69) alignment 
Range on Protein: 876-922
Range on HMM: 2-48/69.0
VMCSSGVGRTGVFIALGIVLERYSVEGMIDLFQTVKTLRIQRSAMVQ
| |||| |||| |||. . . |   | ..|.|  |. .|  |  || 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvm
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 663-740 5.5e-09 29.8 In-house 10-85 (440) alignment 
Range on Protein: 663-740
Range on HMM: 10-85/440.0
DKLELIQEDGESSLLEMEFQRLATDRTEPHRFASATKnvNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINASYIDS
|  . .|..  |   | |.  | .  ..|   ||  .  || |||. ||. |...|| |  ...   |||||||||..
dfadyvqnnrrsrafedewsllpsglsqpsdiaslpn..nkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 436-513 1e-08 29.1 In-house 124-196 (244) alignment 
Range on Protein: 436-513
Range on HMM: 124-196/244.0
YINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKstvkcDCYWPTDVNERCTYGGVEVTLV
||||||.  . .  .|| || |.|.|  .||.|. |.    .|..  ..|.     | |||           . ||| 
yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtlt
HTH_19 Helix-turn-helix domain 110-156 1.4e-08 21.3 Pfam-A 1-47 (64) alignment 
Range on Protein: 110-156
Range on HMM: 1-47/64.0
GRLIQQSRSKAKLSQKDLAARINEKSQVISDYEQGKAIPNAGVLKKM
|. . . |.. .|.|..|| ... . . ||..| ||. | |. |||.
GerLkelRealgltqeelaeklgisrssiskiEnGkrdpsadklkki
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 416-497 1.7e-08 28.8 In-house 3-71 (130) alignment 
Range on Protein: 416-497
Range on HMM: 3-71/130.0
LPYDHTRVKlstvkwqeGSDYINASFLDGFMKPQQYIATQGPMAETIGEFWRMVWEQNSATIVMVTKLQEKstvkcDCYWPT
|... .|..        | .||||||.    . ..|. || |.|.|  .||.|. |.    .|..  ..|.     | ||| 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd
subfamily_CG42327_pd Subfamily CG42327 871-934 1.8e-08 28.4 In-house 247-310 (319) alignment 
Range on Protein: 871-934
Range on HMM: 247-310/319.0
TEPITVMCSSGVGRTGVFIALGIVLERYSVE-GMIDLFQTVKTLRIQRSAMVQTRlSQKKIVLSL
  |..| || ||||||. ||  | ...       .|. |.|  .| .|.  |.|.  | . .   
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltk.eqyefiykv
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 698-784 4.9e-08 26.1 In-house 23-82 (169) alignment 
Range on Protein: 698-784
Range on HMM: 23-82/169.0
TKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINAsyidsyrqqraylatqgpmkntvedfwRMIWEHKSKIIVMLTKLEEKQQ
   .|. |||    .   . ||||  .    |||||||                           |||||  . .||.|   ..|..
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknn
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 698-784 7.5e-08 25.4 In-house 22-81 (169) alignment 
Range on Protein: 698-784
Range on HMM: 22-81/169.0
TKNVNKGKNRFVNIMPYEYNRVKLSFIRATEGSDYINAsyidsyrqqraylatqgpmkntvedfwRMIWEHKSKIIVMLTKLEEKQQ
   .|. |||    .   . ||||  .    |||||||                           |||||  . .||.|   ..|..
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknn
0038934 (Phosphotyrosine protein) phosphatases II 541-598 7.9e-08 27.7 In-house 80-135 (194) alignment 
Range on Protein: 541-598
Range on HMM: 80-135/194.0
RQFHFTAWPDHGVPEFPTSMLSMIRCVRAHHNRLPPdtGPMIVHCSAGVGRTGTFVVI
 ...   .||.|..     .|. .. |  ..|. |.  |   ||| ||.|||||.|. 
ieylklpfpddgtvPsleillrfldlvdeflnedpg..gvvaVHCkaGlgRtGtlvaa
subfamily_PTPDC1_pd Subfamily PTPDC1 543-640 2e-07 25.6 In-house 85-170 (182) alignment 
Range on Protein: 543-640
Range on HMM: 85-170/182.0
FHFTAWPDHGVPEFpTSMLSMIRCVRAHHnrlppDTGPMIVHCSAGVGRTGTFVVIDSMLQRILHGEDNvdiyghVTLLRNQRNFMVQTEDQYFFIHE
..  .|.|.||.   ...| ... |         . | . ||| || ||||  .    . .. | .|.       ..|.|..|   .|| .|  ...|
vynfgwkDygvasl.eriLdivkvvafal.....qegkvavhChaGlGrtGvliacylvyakrltaeka......iklvrskrpksiqtreqvelvke
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 830-897 5.2e-06 20.0 In-house 216-291 (349) alignment 
Range on Protein: 830-897
Range on HMM: 216-291/349.0
ASYTLHHFQFLGWPERGVPVSALPLLQMIQ--------NVQELYITLRTTEPITVMCSSGVGRTGVFIALGIVLER
  | |  .|.  |.. .. .    .|| ..        .  .||.    . .. | ||.| |||||.. | ..|. 
kPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsi
Shisa Wnt and FGF inhibitory regulator 273-313 5.7e-06 15.5 Pfam-A 77-115 (179) alignment 
Range on Protein: 273-313
Range on HMM: 77-115/179.0
VFGIAGGGalVVAVLIIIIICVIVICCCLIRRQRESPSSPL
 . .. .   .. |..|. . ||..|.....   . .. | 
kvvlivsi..ilivvfivvliviftcskcvlekavrrqrpv
PTEN_1 547-596 9.6e-06 20.5 In-house 101-148 (196) alignment 
Range on Protein: 547-596
Range on HMM: 101-148/196.0
AWPDHGVPefPTSMLSMIRCVRAHHNRLPPDTGPMIVHCSAGVGRTGTFV
 ..|||.|  . |.|  | .. ..  .. |. .  .||| ||.||.|| |
pieDhgap..slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv