Gene PTPRD-24 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP078_AA protein Get Run
AqueP078_AA_912-1230 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 909-1133 2e-110 363.2 In-house 1-226 (290) alignment
Range on Protein: 909-1133
Range on HMM: 1-226/290.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCPNGYINACYVDGYSDEYQYIATQGPV
||||..|||||||||.||||||.|||.|||||||.||.|||||.|||||||||||||||||||.||||||||||.| ||||||..||....|||||||||
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

SKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHG-VPEYATS
|.|.|||| |.|||. ..|||.||..|||||||||||||||||.||.||..|..|..|.|||.||....   |.... ..|||..|.|...| |....|.
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

ILQFHRRIKNEYKPTKGPMLVHCSVT
.|......|...|.......|||| |
llvieemyktqrkrgntsivvHCSdt

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 909-1133 4.9e-93 306.2 In-house 1-221 (287) alignment
Range on Protein: 909-1133
Range on HMM: 1-221/287.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDS-GESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRpisghkDCPNGYINACYVDGYSDEYQYIATQGP
||||..||||||.|| ||||||||||..|.. .....  |......|| .||...|.|.|..|..|.      .. . ||||...|||......|....|
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

VSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHG-VPEYAT
...|...||.|........|||... ||. . .| ||||....  .|.....| .|.| ..||.||....  ..........||..|.|...| |.|..|
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

SILQFHRRIKNEYKPTKGPMLVHCSVT
..|......|...|.......|||| |
illvieemyktqrkrgntsivvhCsdt

subfamily_PTPRD_pd Subfamily PTPRD 909-1131 2e-77 256.1 In-house 4-222 (564) alignment
Range on Protein: 909-1131
Range on HMM: 4-222/564.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGeSDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPV
 ||| .. |.||. . ...  |....  ...| . .| ..   | ||  ||.|||| || .|..|... |....   |||| ..|||  . .|||||||.
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPl

SKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLtLLGSDQPPLMITQYHFTSWPDHGVPEYATSI
..|. ||| .||...  .|||.|...|.|||||..|||...|. || . |||..|. |..|.||.. |    ...   ...|.||||||||||||.|||.
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatsl

LQFHRRIKNEYKPTKGPMLVHCS
|.. |....  .|..||..||||
LdlirkvralnepdagPivVhCS

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 909-1132 2.5e-69 228.8 In-house 3-225 (305) alignment
Range on Protein: 909-1132
Range on HMM: 3-225/305.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGesDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKdcPNGYINACYVDGYSDEYQYIATQGPV
 | . .. ... . .|. ..|...|. .| .   ...  || .  ||  ||...|...||.||||.. . ..   . ||||.|||||. . .||..|||.
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPl

SKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTK--DYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYAT
 .||.||| |...|.. .|||.|...|.|| ||.||||.| |.  ..|.|||.|..|.  ..||.||....   .|.    ..||..|.|||||||..||
kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

SILQFHRRIKNEYKPTKG-PMLVHCSV
|.|.. .|.....|  || |.||||| 
sllslikrvqkdqkkdkgvpllVhCsa

0051299 (Phosphotyrosine protein) phosphatases II 908-1131 3.1e-69 229.0 In-house 3-227 (288) alignment
Range on Protein: 908-1131
Range on HMM: 3-227/288.0
NLIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkDCPNGYINACYVDGYSDEYQYIATQGP
. |.| .. ..| . . .|. |....| .| |   |.| ...| | |.  ||. .|. ||..|..|....|  . ...|||| |.|||  . ..||||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgP

VSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLG---SDQPPLMITQYHFTSWPDHGVPEY
 ..|| ||| .||... .||||.|.. | |..|| ||||..... ||...||| .|.|| .|..|....| |.    |. ....|..|.|.|||||||..
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

ATSILQFHRRIKNEYKPTKGPMLVHCS
....|.| |.... .....||..||||
pellldflrlvrkalasgggpvvVHCs

0050432 (Phosphotyrosine protein) phosphatases II 924-1131 3.8e-65 215.6 In-house 38-240 (308) alignment
Range on Protein: 924-1131
Range on HMM: 38-240/308.0
VKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILrpisghkDCPNGYINACYVDGY--SDEYQYIATQGPVSKTVVDFWCLVWQ
 ... ... .|. | |   ... .|.| | || .||. .|. || .|..|       | ...|||| |||||    . ..|||||| ..|| ||| .||.
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

ERPPVIVMVTNVKEEGKVKCQQYWPDS---DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
.. .||||.|.  | |..|| ||||..   ... ||.|.||| .|.|| .|..|...|| ||...  ...|..|.|.|||||||......|.| ..... 
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrks

YkpTKGPMLVHCS
.   .||..||||
l..pggpivVHCs

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 909-1131 5.3e-64 211.3 In-house 4-224 (319) alignment
Range on Protein: 909-1131
Range on HMM: 4-224/319.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDhTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPV
 |.| .. | . . . .|. .....|..|. ...| | .   .. ||  ||. ||. ||  |..| .. | ..    |||| ..||| .. ..||||.|.
eievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegs..dyinasfidgyqerekfiatqaPl

SKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSI
..|. ||| .||.|.  ..||.|...|..|||...|||. . ..|| . ||| .|. | .|||||..|  . |.    .......|.||||.|||.|||.
entiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsl

LQFHRRIKNEYK-PTKGPMLVHCS
|.. .||..  . ...||. ||||
ldllkrirksrektqsgPivvhCs

0040438 (Phosphotyrosine protein) phosphatases II 914-1131 8.4e-64 211.2 In-house 4-217 (317) alignment
Range on Protein: 914-1131
Range on HMM: 4-217/317.0
QFGEFVANGHVKGNEGFKNQFMMLDSGESDhTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkDCPNGYINACYVDGYSDEYQYIATQGPVSKTVV
.. ...   . ... .....|..|.|   | | .|.. | || .||. .|. ||..|..| |..|  | ...|||| ||||..   ..|||||| ..|| 
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntve

DFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHR
||| .||...  ||||.|. .| |..||.||||. .|. ||.|.||| .|..| ....|..... |  |......|..|.|.|||||||.. ...|.| .
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfle

RIKNEYKPTKGPMLVHCS
.... ... .||.|||||
avrealedpggpvlVHCs

0036941 (Phosphotyrosine protein) phosphatases II 925-1131 5.2e-63 208.5 In-house 10-215 (297) alignment
Range on Protein: 925-1131
Range on HMM: 10-215/297.0
KGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILrpisghKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERP
... ... .|. |..   . . .|.| | |. .||. .|. ||..|..|      .| ...||||.|||||. ....|||||| ..|| ||| .||... 
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

PVIVMVTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTLSDEQV--LTEYIIRKIHLTLLGSDqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK
.||||.|.. | |..||.||||.   ... ||.|.||| ...|  |..|..|....| .|.. .....|..|.|.||||||||...|.|.| ..... .|
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlk

--PTKGPMLVHCS
  | .||.|||||
llpsggpvlVHCs

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 910-1131 5.4e-63 208.0 In-house 2-221 (318) alignment
Range on Protein: 910-1131
Range on HMM: 2-221/318.0
IPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVS
|.| .. . |.. . .|.  ..... .|.  |.  |..  |.| ||  ||.|||. ||. |. |....|...    |||| |.|||  . .|||.|.|..
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeeg..sDyinanyidGyrrkkayiaaqaPlp

KTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSIL
.|. ||| .||.    ||||.|...|.||.|...|||..... ||   |.|..|  |..|..|....|  ....   .. |||.|||||.|||| ..|.|
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeee.srqvrqyhytsWpdegvpesgasll

QFHRRIKNEY-KPTKGPMLVHCS
.. |....   |...||..||||
dlvrqvskaqqksgagpivvhCs

0046845 (Phosphotyrosine protein) phosphatases II 930-1131 5.5e-62 205.0 In-house 2-212 (284) alignment
Range on Protein: 930-1131
Range on HMM: 2-212/284.0
FKNQFMMLDSGESDH--TATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHkDCPNGYINACYVDGY-----SDEYQYIATQGPVSKTVVDFWCLVWQE
.. .|..| |   ..  . .|.| | |. .||. .|..||..|..|....|. .  ..|||| |||||       . ..||||||...|| ||| .||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RPPVIVMVTNVKEEGKVKCQQYWPDSD-TKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-
. .||||.|.  | |..|| ||||... .. ||.|.||| .|.|   |..|.. || || .......|..|.|||||||||......|.| | ... .. 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-PTKGPMLVHCS
 |..||..||||
lpgggpivVHCs

0047943 (Phosphotyrosine protein) phosphatases II 924-1131 2.3e-61 203.0 In-house 8-213 (273) alignment
Range on Protein: 924-1131
Range on HMM: 8-213/273.0
VKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILrpisghKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQER
 .|. ... .| .| |   ..| .|.| | || .||. .|. ||..|..|      .| ...|||| |||||  . ..|||||| ..|| ||| .||...
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

PPVIVMVTNVKEEGKVKCQQYWPDSD---TKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK
 .||||.|.. | |..|| ||||..    .. ||.|.||| .|..   |..|.. || ||... ....|..|.|.|||||||.. .|.|.| . ... ..
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkale

P--TKGPMLVHCS
    .||..||||
alpsngpvvVHCs

subfamily_PTPRB_pd Subfamily PTPRB 908-1131 8.1e-61 200.6 In-house 5-226 (293) alignment
Range on Protein: 908-1131
Range on HMM: 5-226/293.0
NLIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGP
. | . .| |.|.. . . . .|.... .| . ..|.. ..  .. |.  ||. ||. || .|. | .......  . |||| |..||. . ..||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesg..sDYinanyipgynsprefiatqGP

VSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDS-DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLlgsDQPPLMITQYHFTSWPDHGVPEYAT
. .|| ||| .||...  .|||.|.. |.|||||..|||.  ..  ||  .|||  |..|....||.....    ..    ..|||||||||||||| ..
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektk

SILQFHRRIKNEY--KPTKGPMLVHCS
..|.| |.....   . .|.|..||||
tlldfvrtvreaiektaskrPivvhCs

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 926-1133 4.3e-60 197.9 In-house 13-236 (301) alignment
Range on Protein: 926-1133
Range on HMM: 13-236/301.0
GNEGFKNQFMMLDSGEsDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPP
 ...|..|.  |..|| |...||||. .|| |||| ||.|||||||||.| .  . | . |||| |.||||.. ..||.|||. ||.||||.|.|||.| 
hsnkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

VIVMVTNVKEEGKVKCQQYWPDSD--TKDYGPFSVTLSDEQVLTEYIIRKIHLTLL--------------GSDQPPLMITQYHFTSWPDHGV-PEYATSI
 |||||| ||. | ||.||||.|.  ....|||.|||..|||. ...||.. ...                ||. .  ..|.. |.||..|| .|..| .
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

LQFHRRIKNEYKPTKGPMLVHCSVT
   .  |. . |. .||..|||| |
qviddvihrqqkigggpvvVHCSdt

subfamily_PTPRG_pd Subfamily PTPRG 910-1131 5.3e-60 198.2 In-house 1-228 (563) alignment
Range on Protein: 910-1131
Range on HMM: 1-228/563.0
IPVGQFGEFVANGHVKGNEGFKNQFMML--DSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCPnGYINACYVDGYSDEYQYIATQGP
.|| .| . ||. | .|. ||...|  |   . ..| .|.    |.||  ||  ||| ||  |. |.|..|.|.    |||| |.|||  . ..||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

VSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTL---LGSD--QPPLMITQYHFTSWPDHGVP
. .|. ||| ..|...  .|||.||..|.|. ||..|||  ....|| ..||| .|.||. | .|.. .        .  .  ....|||.|.|||||||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

EYATSILQFHRRIKNEYKPTKGPMLVHCS
|...  |.| .. .   | . ||..||||
ehslpvLifvkkssaankaeaGPivvHcs

0045450 (Phosphotyrosine protein) phosphatases II 909-1131 1.8e-59 197.3 In-house 8-242 (307) alignment
Range on Protein: 909-1131
Range on HMM: 8-242/307.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGES--DHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHkDCPNGYINACYV--------DGYSDE
.|.. ..  .|.  . ....|.. .| .| | .    .. ...| | || .||. .|. ||..|..| ...|. . ...|||| ||        |||   
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlk

YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSD-TKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWP
 ..|||||| ..|| ||| ..|...  ||||.|. .| |..|| |||||.. .. ||.| ||| .|..| .|..|....| |. .......|..|.|.||
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp

DHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCS
|||||..  ..|.| ..... .   | .||.|||||
dhgvppsfeelldfieevrkaleelpkggpvlVHCs

0043336 (Phosphotyrosine protein) phosphatases II 911-1131 1.9e-59 196.7 In-house 3-218 (278) alignment
Range on Protein: 911-1131
Range on HMM: 3-218/278.0
PVGQFGEFVANGHVKGNEGFKNQFMMLDSGESdHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSK
.| .. ..... . ... .....|  |.|     | ...| | || .||. .|. || .|..| ...|. |  ..|||| |||||.   ..|||||| ..
svkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpe

TVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPdSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQ
|| ||| .||... ..|||.|. .| |.|||.|||| .... ||.|.||| .|..|  |..|....| ||.... ...|.||...||||||||  ...|.
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllld

FHRRIKNEYKPTKGPMLVHCS
| ..... ... .||.|||||
flkavrealedsngpvlVHCs

0039614 (Phosphotyrosine protein) phosphatases II 912-1131 3.1e-58 192.9 In-house 16-230 (297) alignment
Range on Protein: 912-1131
Range on HMM: 16-230/297.0
VGQFGEFVANGHVKGNEGFKNQFMMLDSGESDhtATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHkDCPNGYINACYVDGYSD-EYQYIATQGPVSK
.. .  ..   . ... .....|..| |   |   ...| | || .||. .|. ||..|..| |. |. | .. |||| |||||.    ..|||||| ..
lsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpe

TVVDFWCLVWQERPPVIVMVTNVKEEGKvKCQQYWPDSDTkDYGPFSVTLSDEQVLTEYIIRKIHLTLlgsDQPPLMITQYHFTSWPDHGVPEYATSILQ
|| ||| .||... .||||.|. .| |. ||.||||.. .  ||.|.||| ....|  |..|....|    .......|....|.|||||||......|.
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellle

FHRRIKNEYK--PTKGPMLVHCS
| . ... ..  | .||.|||||
flelvrealaelpkggpvlVHCs

DSPc_SM00195 930-1131 6.6e-58 191.5 In-house 2-203 (263) alignment
Range on Protein: 930-1131
Range on HMM: 2-203/263.0
FKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHkdCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVM
.|..|  |.. .|... | .  ..||  ||. ||..||..|..| .. ..   .. |||| |..|.. . .||||||| ..|| ||| .||.|. ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTLSDEQVLT-EYIIRKIHLTLLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
.|. .|.|| ||..|||..  .....| .||.| ...    |.|.|...||  |  . .  .|||....|||||||. ..|.|.. | .|.... ..||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCS
.||||
vVhCs

PTPc_SM00194 930-1131 6.6e-58 191.5 In-house 2-203 (263) alignment
Range on Protein: 930-1131
Range on HMM: 2-203/263.0
FKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHkdCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVM
.|..|  |.. .|... | .  ..||  ||. ||..||..|..| .. ..   .. |||| |..|.. . .||||||| ..|| ||| .||.|. ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTLSDEQVLT-EYIIRKIHLTLLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
.|. .|.|| ||..|||..  .....| .||.| ...    |.|.|...||  |  . .  .|||....|||||||. ..|.|.. | .|.... ..||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCS
.||||
vVhCs

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 920-1131 2.6e-57 189.3 In-house 19-231 (298) alignment
Range on Protein: 920-1131
Range on HMM: 19-231/298.0
ANGHVKGNEGFKNQFMMLDSGES---DHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPVSKTVVDFW
|  . |.  |....|  |.|..|   ... .|. .|.||  ||.|.|. .|  |..|. ... ...   |||| ....|...  .||||.|. .||.|||
avkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadees..dYiNAsflhaykgrnafiatqaPltetvedFW

CLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK
 .|..|   .|||.||..| .|.|...||||. .. || ..|.|  ... ...|.||....   ..    .. | |||||||.||||.|||.|.. |...
rmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvr

NeYKPTKG--PMLVHCS
  ..   |  |..|.||
a.sqqqagnkpvivqCs

subfamily_Ptp69D_pd Subfamily Ptp69D 916-1132 2.7e-57 189.2 In-house 10-228 (307) alignment
Range on Protein: 916-1132
Range on HMM: 10-228/307.0
GEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPVSKTVVDF
 | . . . . ..|... . .| . |.|....|.    |.| ||. .|. .|..|..|..| |..|    |||| .. || .. ..|| |.||  |. ||
eealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkeds..dYinasfikgykekkkfiaaqdPveatigDf

WCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQ----PPLMITQYHFTSWPDHGVPEYATSILQF
| ....    .|||..|..|  . ||..|||. |.. ||   |.| .|.  ..||||.....  . .         ..|||.|.|.|  ||| |...|..
WRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkl

HRRIKNEYKPTKGPMLVHCSV
 ..... ||  ..|..|||| 
ieqvrelyklnrsPivvhCsa

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 918-1131 3.8e-57 188.6 In-house 11-220 (288) alignment
Range on Protein: 918-1131
Range on HMM: 11-220/288.0
FVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWC
 ||. . ....||....  | . |.... |.|  . |.  ||. ||. || .|. |.     ..  . |||| |.||.  . .|||||||. .|| ||| 
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeag..aDYinasyidgekkkkkyiatqgPladtvndfWe

LVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDT-KDYGPFSVTLSDEQVLTEYIIRKIHLTllgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK
||....   |||.|.. |.|| ||..||||.|. | || . ||| ... |.... ||. |     ..  | ||||....|||||||| .. .|.. | .|
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvk

NEYKPTKGPMLVHCS
.  .   ||..||||
vanqadtgpiivhCs

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 925-1131 2.2e-56 186.0 In-house 12-216 (281) alignment
Range on Protein: 925-1131
Range on HMM: 12-216/281.0
KGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERP
. |.||....  | . . |.|||   .. |.| ||. ||| ||  |. . | . .|..   |||| .|.||..| .|||||||| ...|.|| .||... 
ndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenknt..DYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkv

PVIVMVTNVKEEGKVKCQQYWPDSD-TKDYGPFSVTLSDEQVLTEYIIRKIHLtlLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK-NEYKPT
 .|||||.  |.||.|| .|||| . .  || . |.   |.  ..|| ||..|    .. ..  ..| ..|.|||||||. .. .|.|.. ..  . | |
saivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekkt

KGPMLVHCS
| |...|||
kaplvihCs

subfamily_PTPRA_pd Subfamily PTPRA 908-1132 4.6e-56 185.1 In-house 12-237 (330) alignment
Range on Protein: 908-1132
Range on HMM: 12-237/330.0
NLIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGP
  .|| .. | .       |. |...|  | .|. . |  .     ||  ||. ||. || .|.|| ...|...    |||| ..||| .  ..||.|||
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvees..dyinasfidGykekdkfiaaqGP

VSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSD---QPPLMITQYHFTSWPDHGVPEY
 ..|| ||| ..|. .   |||.|..||  . ||.|||||  .  ||   |.. ||.|| .| .||. .. |.     ... ...|.||||||| |||  
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

ATSILQFHRRIKNEYKPTKGPMLVHCSV
.  .|.. ...|.  . . ||. |||| 
piGmlkllkkvkklnqqsagpivvhcsa

subfamily_PTPN6_pd Subfamily PTPN6 921-1131 1e-55 183.9 In-house 19-235 (306) alignment
Range on Protein: 921-1131
Range on HMM: 19-235/306.0
NGHVKGNEGFKNQFMMLDSGESDH--TATVGLTPSNKLLNRFANIVVYDDNRIILRpisGHKDCPNGYINACYVDGY--SDEYQYIATQGPVSKTVVDFW
... ....||...|  |.  |. .  . . |  |.||  ||. ||. .|..|.||.    ..   . |||| |...   . . .|||||| ...|| |||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

CLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSD-TKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRI
 .||||   ||||.|.  | || || .||||.  ...||  |||  .|. |..||.|.....   ...    . ||||.||||||||.    .|.| . .
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledv

KNEYKPTK----GPMLVHCS
..... ..    ||..||||
nrkqeeleeaeagpivvhCs

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1131-1226 2.1e-54 179.4 In-house 179-274 (290) alignment
Range on Protein: 1131-1226
Range on HMM: 179-274/290.0
SVTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQL
||||.|.|||||||.|.||||||...||||.||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||...|.
svtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqg

subfamily_PTPRK_pd Subfamily PTPRK 928-1131 2.3e-54 179.4 In-house 22-218 (314) alignment
Range on Protein: 928-1131
Range on HMM: 22-218/314.0
EGFKNQFMMLDSGesdhtATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVI
 |||...  |  |       .     |.  ||. .|. ||  |..| .| |  |  . |||| ..|.|    ..|.||||. .|| ||| ||..|.   |
ygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasi

VMVTNVKEEGKVKCQQYWPDSDTKdYGPFSVTLSDEQVLTEYIIRKIHLTLL-GSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
||.|...|.|.||| .|||.  .. ||.. |.| . ..|.|...|   .. |  . .   .. |..|..||||.|| .||..|.. ||.|.  ....|..
vmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGri

LVHCS
.||||
vvhCs

0045098 (Phosphotyrosine protein) phosphatases II 943-1131 2.7e-54 179.8 In-house 22-214 (278) alignment
Range on Protein: 943-1131
Range on HMM: 22-214/278.0
DHTATVGLTPSNKLLNRFANIVVYDDNRIIlrpisghkdcpnGYINACYVDGYsdEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQ
  . |..| ..|. .||. .|. || .|..            .|||| |.|||    ..||||||  .|| ||| ..|... .||||.|...| |..|| 
pseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

QYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLL---GSDQPPLMITQYHFTSWPDHGVPEYA--TSILQFHRRIKNEYK-------------PTKG
||||..... ||.|.||| .|.|| .|..|....| |    .| ... .|..|...|||||||..   .|.|.. ..|.. .|             . .|
qywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PMLVHCS
|.|||||
pvlVHCs

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 948-1131 2.7e-53 175.7 In-house 3-183 (250) alignment
Range on Protein: 948-1131
Range on HMM: 3-183/250.0
VGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVkCQQYWPD
|.  |.||  ||.|.|. .|  |..| . .| |..   |||| ...||...  .||||||...|..||| .|..|   .|||.||.||..|. ..|||| 
vakkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

SDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCS
  .. ||   |.| .... ..|..||. |.   . .   .. |.||..||| ||||.||..|.. .... . .   ..|..|.||
ekaekyGdvtvsllskeefadytkrklklska.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCs

Y_phosphatase Protein-tyrosine phosphatase 954-1131 4.3e-53 175.5 Pfam-A 1-178 (235) alignment
Range on Protein: 954-1131
Range on HMM: 1-178/235.0
NKLLNRFANIVVYDDNRIILrpisG----HKDcpngYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWP--D
||  ||. .|..||..|. |         ..|    |||| ||.||... ..||||||...|. ||| .||||.  ||||.|...|.|..||.||||  .
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee

SDTKDYGPFSVTLS-DEQ-VLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCS
.... || ..|.|  .|.   .||..||..|.  .... . ...|.|.|.|||||||| ..|.|.. |..... ....||..||||
eesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs

Y_phosphatase Protein-tyrosine phosphatase 954-1131 4.3e-53 175.5 In-house 1-178 (235) alignment
Range on Protein: 954-1131
Range on HMM: 1-178/235.0
NKLLNRFANIVVYDDNRIILrpisG----HKDcpngYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWP--D
||  ||. .|..||..|. |         ..|    |||| ||.||... ..||||||...|. ||| .||||.  ||||.|...|.|..||.||||  .
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee

SDTKDYGPFSVTLS-DEQ-VLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCS
.... || ..|.|  .|.   .||..||..|.  .... . ...|.|.|.|||||||| ..|.|.. |..... ....||..||||
eesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs

0040439 (Phosphotyrosine protein) phosphatases II 946-1131 4.4e-53 175.8 In-house 3-187 (249) alignment
Range on Protein: 946-1131
Range on HMM: 3-187/249.0
ATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYW
 .|.| | || .||. .|. || .|..| ...|    ...|||| |.|||    ..|||||| ..|| ||| ..|...  ||||.|. .| |..||.|||
ysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCS
|..... || |.||| ...|. .|..|...|| |  |...........|.|||||||..  ..|.| ..... ..  |..||.|||||
plggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCs

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1132-1222 1.7e-52 173.2 In-house 175-265 (287) alignment
Range on Protein: 1132-1222
Range on HMM: 175-265/287.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|.|.|.|||||||.|..|||||...||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 
vkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtve

0042113 (Phosphotyrosine protein) phosphatases II 948-1131 1.5e-51 170.5 In-house 3-184 (245) alignment
Range on Protein: 948-1131
Range on HMM: 3-184/245.0
VGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCPngYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPD
|.| | || .||. .|. ||..|..| |..|. |..  ||||.|||||    ..|||||| ..|| ||| ..|...  .|||.|.  | |.|||.||||.
vallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

SDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCS
.... || |.||| .|..| .|..|....| |  | .......||...|||||||..  ..|.|...... .. . .||.|||||
gesltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCs

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 907-1131 4.3e-51 168.7 In-house 3-220 (315) alignment
Range on Protein: 907-1131
Range on HMM: 3-220/315.0
KNLIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGEsDHTATVGLTPSNKLLNRFANIVVYDDNRIILrPISGhKDCPNGYINACYVDGYSDEYQYIATQG
.. ||. |.  .||. .   ..|||...  .  |.  |   |     ||  ||. ||. ||  |. | |.   .|    |.|| ..|||. . .|||.||
hqpipldqlityvaqkkastkngfkqdyesipggq.lhpldvakkienkqknryiniiaydksrvql.plle.ndphsdyvnanfidGynkkrryiaaqg

PVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSdTKDYGPFSVTLSDEQVLTEYIIRKIHLTlLGSDqpPLMITQYHFTSWPDHGVPEYAT
|   .| ||| ||..|    |||.||. |. | |...||||     ||...||. .|.| ||| .| .  .  |..     . |.|.||||| |||.|..
pnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvv.fgdn..irevvqlhytswpdmgvpkyti

SILQFHRRIKNEYKPTKGPMLVHCS
......|..|   . . |...||||
plmnlirtvkqhhtnsvgaivvhcs

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 910-1131 6.6e-51 168.0 In-house 3-218 (315) alignment
Range on Protein: 910-1131
Range on HMM: 3-218/315.0
IPVGQFGEFVANGhvKGNEGFKNQFMMLDSGESdHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVS
||| ||  || .   .    | ..|  |   .  .  .|. .. |   ||. ||. .| .|..|  |  . |  . |||| |. .. |.  |||.|||  
ipvaqfpafvnkn..rhtalfseefhdlpdPdi.yrqrvaretinfkknryknilPldsarvkleviddsPd..sdyinasyiksvdddkayiasqgPlk

KTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPD--SDTKDYGPFSVTLSDEQVLTEYIIRKIhLTLLGSDQppLMITQYHFTSWPDHGVPEYATS
 .| ||| .|.||..  |||||. .|. |.||.|||||  .|. ..| ..|.| . .  |. ..||.  |  . ..    .||..|| |||.||.. ..|
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrksees..rtvtqfqftewPdkGvdkqtss

ILQFHRRIKNEYKPTKGPMLVHCS
.|.. . .| . .. . ..|||||
llklikevkadngkkefsllvhcs

subfamily_PTPN12_pd Subfamily PTPN12 942-1131 3.1e-49 162.4 In-house 28-215 (290) alignment
Range on Protein: 942-1131
Range on HMM: 28-215/290.0
SDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKdcPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKC
. .....| ...|.  ||. .|. || .|. |. |....   ..|||| .. | ... .|||.|||..||. ||| ..|. .  ..||. .. | || ||
kvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

QQYWPDSDTK--DYGPFSVTLSDEQVLT-EYIIRKIHLTLLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCS
..|||..  .   .|.|.|||..|. .. ...|| ....  .  .   ...|.|.|.|||||||. |.|.|.. . ...  .  . |..||||
erYWpeegeeelefgefevtleeekavdddflirtLkveaqkesr...kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCs

0037934 (Phosphotyrosine protein) phosphatases II 948-1131 3.9e-49 162.8 In-house 4-186 (243) alignment
Range on Protein: 948-1131
Range on HMM: 4-186/243.0
VGLTPSNKLLNRFANIVVYDDNRIILrpisghKDcpNGYINACYVDGYSdeyQYIATQGPVSKTVVD----FWCLVWQERPPVIVMVTNVKEEGKVKCQQ
..| | |.  ||. .|. ||..|..|      ..  ..|||| .....    ..|||||| ..|| |    || ..|...  ||||.|. .| |..|| |
iallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPdsDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--------YKPTKGPMLVHCS
|||  ... ||.|.||| .|..| .|..|...|. |. |........||...|||||||.  ...|.|.. ...         . ...||.|||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 953-1132 5.3e-48 158.3 In-house 2-181 (237) alignment
Range on Protein: 953-1132
Range on HMM: 2-181/237.0
SNKLLNRFANIVVYDDNRIILRPISGHkdcpNGYINACYVDGYSD-EYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDT-
 ||. ||..|||.|| .|..|.   .       ||||.|..|.     .|||.|||.  .  ||| .||||.  ||||.| . |  ..|| .|||..|  
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

KDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSV
. || ..|.|  .. ...| .| . |.  .. .   .| ||.||||||.|||......|.| ..| |. .  .  || ..||| 
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsa

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 954-1132 9.8e-48 157.4 In-house 8-183 (239) alignment
Range on Protein: 954-1132
Range on HMM: 8-183/239.0
NKLLNRFANIVVYDDNRIILRPISghKDCPNGYINACYVDGYSDE-YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKd
||  ||.|||| || .|..|  .|  .|  . |||| |.  |      |||||| |. .  ||| ..||||  ||||.| . |  | ||.|||||| .| 
nkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSV
|  . |||   .|...|||| . .. .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||| 
ycnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsa

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 954-1132 1e-47 157.3 In-house 7-182 (239) alignment
Range on Protein: 954-1132
Range on HMM: 7-182/239.0
NKLLNRFANIVVYDDNRIILRPISghKDCPNGYINACYVDGYSDE-YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKd
||  ||.|||| || .|..|  .|  .|  . |||| |.  |      |||||| |. .  ||| ..||||  ||||.| . |  | ||.|||||| .| 
nkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSV
|  . |||   .|...|||| . .. .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||| 
ycnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsa

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 923-1132 1.9e-47 156.5 In-house 4-208 (283) alignment
Range on Protein: 923-1132
Range on HMM: 4-208/283.0
HVKGNEGFKNQFMMLDSgeSDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkdcpnGYINACYVD---GYSDEYQYIATQGPVSKTVVDFWCLV
.|..|. |....  |     |  |..  .  ||  ||. .||..| .|. |.. |        ||||...     | .. .||..|.|. .|||||| .|
rvnnnklfrevlkrlsv..pdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmv

WQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
..|.   |||.|...|. ..|| ||||   ..|||.| ||| .|     .||... |   .| .  |... | .  | . |      |...| . | .  
fdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqt

KPTKGPMLVHCSV
.  |||..|||| 
eskkgPivvhCst

subfamily_PTPN9_pd Subfamily PTPN9 917-1118 4.1e-47 155.6 In-house 5-205 (297) alignment
Range on Protein: 917-1118
Range on HMM: 5-205/297.0
EFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFW
|.||  . ||..| ..... . . .   |...  ...|   ||..... ||. |. |  .....     |||| .||||  .  .||||||. ||| |||
elvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedea..sdyinanfvdGykqkkafiatqGplkktvsdfW

CLVWQERPPVIVMVTNVKEEGKVKCQQYWP--DSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRR
 .||...  ||||.| | |.|..||.||||  . .....| .||.  . ..  .| .|.....    ..    .| . |.||||.|||. |.|.|.. . 
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktees.rkvthfqflsWPdyGvPssaaslldvlek

IKNE
....
vrek

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 910-1131 5e-47 155.2 In-house 2-217 (515) alignment
Range on Protein: 910-1131
Range on HMM: 2-217/515.0
IPVGQFGEFVANGHVkgNEGFKNQFMMLdSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVS
.|. ||  ||.         | ..|  |  |   .  ||     |   ||. ||. || .|..|  |    .  . |.|| |. ..  .  |||.|||  
lplaqfPafvnknrh..ttlfseefhdl.pgpniypqtvaqeeinfkknryknilPydsvrvklevindnPh..sdyfnasyipsfdndkayiasqgPnk

KTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPD--SDTKDYGPFSVTLSDEQVLTEYIIRKIHLtlLGSDQpPLMITQYHFTSWPDHGVPEYATS
 .| ||| ||.||..  |.|||. ||. |.|| .||||  .|.  .| ..| |   .  |. |.||...  | .|.    .||.||| |||.|||. ..|
asvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgdd.srtvtqfhfteWPdkGvpkhtss

ILQFHRRIKNEYKPTKGPMLVHCS
.|.. . .| .    . |...|||
llklikevkadhgqythpliihcs

subfamily_PTPN3_pd Subfamily PTPN3 933-1131 5.8e-46 151.6 In-house 20-216 (280) alignment
Range on Protein: 933-1131
Range on HMM: 20-216/280.0
QFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRpisghkDCPNGYINACYVDG----YSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIV
|| .|   . . . ..   | |   ||. .|. ||. |..|.      . .. |||| ||.      .   .|||||||..||. ||| .||...  .||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MVTNVKEEGKVKCQQYWPDS-DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPML
|.|.. |.|.||| ||||.. |. .|| |||... |.  ..|..|.. |.   ...   .|.|  ...|||||||. ....|.| .|...  . .. |..
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketke.erkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvv

VHCS
||||
vhCs

subfamily_PTPN23_pd Subfamily PTPN23 923-1131 4.9e-44 145.3 In-house 10-220 (288) alignment
Range on Protein: 923-1131
Range on HMM: 10-220/288.0
HVKGNEGFKNQFMMLDSGESDHTAT--VGLTPSNKLLNRFANIVVYDDNRIILRpisGHKDcpnGYINACYVDGYSDE-YQYIATQGPVSKTVVDFWCLV
 ..|. .....|  |.. .  ..    . .   .   ||. .|. || ||. ||   |.||    ||||..| . |    ..||||.|  .|. ||| .|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskD...DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WQERPPVIVMVTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKN
.... .||||... .| || |...||| .  .|. .|..||||.... . ... |...|. |..|.   ...  ..||||..|||.   ..|||   ...
yeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadav.ksvshlqltsWpelGvPasPetllqfldeves

E----YKPTKGPMLVHCS
      ...| |..||||
ayeavqrksktPlvvhCs

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 947-1132 1.4e-43 144.4 In-house 54-233 (319) alignment
Range on Protein: 947-1132
Range on HMM: 54-233/319.0
TVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTnvkeegKVKCQQYWP
|    . ||  ||. ||. .| |.. |... |       |||| .|.||  . .|||.|||   |. ||| ..|. .   ||..|      | || ||||
tfanldqnkdknriinilafdknvvklerliGeef..sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

DSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSV
    . .. | | ..  .   ||..|.|.|.  |  .    |||.||  |||.|||.|.. .... ....     .  . ...|||| 
lkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsa

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 947-1132 3.7e-43 143.1 In-house 18-197 (284) alignment
Range on Protein: 947-1132
Range on HMM: 18-197/284.0
TVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTnvkeegKVKCQQYWP
|    . ||  ||. .|. .| |.. |... |       |||| .. ||  . .|||||||   |. ||| ..|. .   ||..|      | || ||||
tfanldqnkdknrighilafdknvvklerliGeef..sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

DSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSV
    . .. | | ..  .   ||..|.|.|.  |  .    |.|.||  |||.|||.|.. .... ....     .  . ...|||| 
lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 952-1132 7.7e-43 141.5 In-house 26-210 (274) alignment
Range on Protein: 952-1132
Range on HMM: 26-210/274.0
PSNKLLNRFANIVVYDDNRIILRPISGHKDCpNGYINACYVDGYSDEY-QYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDT
. ..  ||. .|.  .  |..|.. |....    |||| |. ||. |   |.|||||...|| ||| ...||. .||||.|..||. . ||..|.||.  
fgsqtknryktilPnensrvllesesseded.ssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaed

K----DYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPplmITQYHFTSWPDHGVPEYATSILQFHRRIKNE---YKPTKGPMLVHCSV
      || .... ..     .| .||. |  | . .    .. | .|.|||| .|. |...|.. . ....    .   .|..|||| 
yeiserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsa

subfamily_PTPN13_pd Subfamily PTPN13 941-1132 1.1e-42 141.2 In-house 24-211 (273) alignment
Range on Protein: 941-1132
Range on HMM: 24-211/273.0
ESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkdcpngYINACYVDG--YSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGK
 .  |..|| . .||  ||. |.. ||. |..|   .|       |||| ..      |||.|||.|||. .|| ||| .||. .  ||.|||. ||.||
kpldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk

VKCQQYWPDSDTKD---YGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSV
|||..|||.|  |    .. . |.| . | | .. .|..... . | .    ... .|..|||||||  |...||| .....  .  .||..|||| 
vkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsa

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 907-1131 4.6e-41 135.9 In-house 7-225 (297) alignment
Range on Protein: 907-1131
Range on HMM: 7-225/297.0
KNLIPVGQFGEFVANGHVkgNEGFKNQFMMLdSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISghKDCPNGYINACYVDGYSDeyQYIATQG
.. ||. .|  .| ...    . |...|  |      ...||     |   .|..||. || .|..|. .   .|    |.|| .| |.    ..|.|| 
rrpiplsdfatlvqknrh..tdvfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqm

PVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKvKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLlGSDQPPLMITQYHFTSWPDHGVPE--Y
|   || ||| .|..|.. .|||... .|. | ||..||.|. .. .|  ||.|.  .  . .| |....|  |. .   .. ||.|..|||. |..   
PmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkds

ATSILQFHRRIKNEYKPTKG-PMLVHCS
|.|.|..   ...... ..  |.||||.
assllklisevrkdfsqnaegPllvhcl

subfamily_PTPRN_pd Subfamily PTPRN 923-1131 1.8e-40 133.5 In-house 24-232 (297) alignment
Range on Protein: 923-1131
Range on HMM: 24-232/297.0
HVKGNEGFKNQFMMLDSGESDH-TATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYV-DGYSDEYQYIATQGPVSKTVVDFWCLVW
|.| .. .....  | . |..  |..|. .. |   || .... ||..|. |.  . ...  . ||||  . |    .  |||||||...|| ||| .||
hlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaek..sdyinasaildhdprapayiatqgplastvadfwqmvw

QERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLT-EYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
..   |||..|...|||  .|..||||  .. |. . | |  | . . .|..| ..|  | ...    .||.|| |||..|||  | |.|.| |..   |
eqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPasaksllefrrkvnksy

KPTKGPMLVHCS
.    |..||||
rGrscpivvhcs

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 912-1131 8.9e-40 131.8 In-house 7-229 (325) alignment
Range on Protein: 912-1131
Range on HMM: 7-229/325.0
VGQFGEFVANGHVKGNEGFKNQFMMLDSGESdHTATVGLTPSNKLLNRFANIVVYDDNRIILRPIsgHKDCPNGYINACYVDGYSDEYQYIATQGPVSKT
| .. |.| . . . ..|| ..| .| | ..  . .|   | ||  ||| |.| .| .|..|     ..|    |||| |.  . .   ..|.| | ..|
vvnlvehvekkkaqdqdgfahefgllpsddg.iakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltat

VVDFWCLV--WQerPPVIvMVTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYATS
. |.| ||  |.   .|. .|.|. ..|| .| .|||.   ..| .|.. | |   . ...|. |....    ..   . . |... ||.| ||... ..
indlWrlvldWr..csvv.vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqv.kkGetrsvkqfqlqswddmGvqkrpat

ILQFHRRIKNEY---KP---TKGPMLVHCS
.. . . .|.     .    . .|.|||||
lisilqlvkavservtantkastpilvhcs

subfamily_PTPN1_pd Subfamily PTPN1 930-1132 1.2e-39 130.7 In-house 8-210 (290) alignment
Range on Protein: 930-1132
Range on HMM: 8-210/290.0
FKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRpisghkDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVM
.|. .. ..   ||.....  .|.|. |||. ..  ||  ||.|.      .  | ||||  |.    . .|| ||||...||  || .||...   .||
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle......radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

VTNVKEEGKVKCQQYWPDSDT-----KDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPT
. .| |....||.||||  .       .   ..|.|  |..  .|..|...|. | ...    |...|.|.||| ||||  .. |.|  ....    .. 
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqet.reilhfhyttwpdfgvpespaaflkflfkvresGslssd

KGPMLVHCSV
.|| ..||| 
vGpavihcsa

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 937-1131 8.8e-38 124.8 In-house 4-205 (270) alignment
Range on Protein: 937-1131
Range on HMM: 4-205/270.0
LDSGESDHTaTVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkDCPNGYINACYVDGYSDE-YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKE
|| .|.... ..  .  .| |||.|.|.     |..| ...   |    |||| || |...|  .|||..||.  |. .|| ..|.|. . |||.|...|
ldkeetses.dlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

EGKVKCQQYWPDSDTK----DYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpPLMitQYHFTSWPDHGVPEYAT------SILQFHRRIKNEYKPT-KG
.|. ||..||| .  .     .|  .|. . |.  . ||.....|.  |. .  |.   .....|||||||. .       ..|.  | ...  | . |.
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeer.rlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka

-PMLVHCS
 |.|||||
ePllvHcs

subfamily_PTPN14_pd Subfamily PTPN14 943-1131 6e-37 122.2 In-house 38-237 (300) alignment
Range on Protein: 943-1131
Range on HMM: 38-237/300.0
DHTATVGLTPSNKLLNRFANIVVYDDNRIILRPisgHKDCPNGYINACYVDG--YSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVK
| . ...  | |.  ||| ... |.|||. | |    |.  .|||||  .     . |..||..|||. .|| ||| .||..   .|||.|. .|.|| |
dallstaklpenaeknrfkdvlPyednrvelsp...tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

CQQYWPDS----DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQP-PLMITQYhfTSWPDHGVPEYATSILQFHRRIK------NEY---KPTKGPM
. .|.|..    .| ..| | ||    .  . .| ....|  | | .   ... ||  | ||||||||  .. |.. ....      |.    | .| |.
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

LVHCS
|||||
lvhCs

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 957-1133 2.1e-35 116.9 In-house 41-220 (287) alignment
Range on Protein: 957-1133
Range on HMM: 41-220/287.0
LNRFANIVVYDDNRIILrpiSGHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDT-KDYGP
 ||.|... .||.|..|   | . .    |||| || .| |. ..||.|||.. || |||..|...|  .....|   ||.. || .|||. .     | 
knryadvlPiddtrvll...saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGG

FSVTLSDEQVL-TEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-----KPTKGPMLVHCSVT
.||.| | ...  || .| . |  | . .   .. |... ||||....  | ....|   .|.           ||..||..| 
ysvvlldydikePeygvralrlidletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

subfamily_CG7180_pd Subfamily CG7180 949-1131 2.8e-35 116.4 In-house 37-231 (296) alignment
Range on Protein: 949-1131
Range on HMM: 37-231/296.0
GLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCPngYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKvKCQQYWPDS
||   |.  ||  ..| || ||..|. . |...    |||| |||..  . .|| |..|. .|| .|| ||..|    .|..|.. .  | ....|||  
glrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLL---------GSDQPPLMITQYHFTSWPD-HGVPEYATSILQFHRRIKN-----EYKPTKGPMLVHCS
  ..||.. | .  |. ...  ||...||           . . .  .......| |.  . ||  ....... ||..      . .|..||..|..|
skeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvss

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 909-1132 1e-34 114.6 In-house 3-178 (392) alignment
Range on Protein: 909-1132
Range on HMM: 3-178/392.0
LIPVGQFGEFVANGHVkgNEGFKNQFMMLDSGESdHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPV
 ||| ||  || . .   .  | ..|  | . .  .  ||. .. |.  ||. ||. || .|..|  |    |  . |.|| |....  |  |||.||| 
pipvaqfpafveknrh..salffeefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddipd..sdylnasyipsfdnekayiasqgpn

SKTVVDFWCLVWQERPPVIVMVTNVKEEGkvkcqqywpdsdtkdygpfsvtlsdeqvlteyiirkihltllgSDQPPLMITQYHFTSWPDHGVPEYATSI
. .. ||| .|.||..  |.|||..||                                               .    ..|.||| |||..||....|.
aaslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssl

LQFHRRIKNEYKPTKGPMLVHCSV
|.| . .| ..     |...||| 
lkfikevkadfGqythpliihcsa

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 952-1225 1e-34 114.7 In-house 31-285 (297) alignment
Range on Protein: 952-1225
Range on HMM: 31-285/297.0
PSNKLLNRFANIVVYDDNRIILRPISGHKDcpngYINACYVDGY--SDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSD
.|    ||. .|. .||.|. |.     .|    |||| ||       ...|| .|||.|.|| ||| ||...   |||||....|.|. ||  |||...
nsslrknryrdilatddtrvkllrviterd....yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

TKDYGPFSVTLSD-EQVLTEY---IIrkIHLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYkpTKGPMLVhcsvtqfqvtnwdstGE
 .     .| .    ..  |.   |.    |.|.  ..   ...   | ||||||||     . .|. .. .       ||..               . 
qerlkagdvvveflsstsdefdrvil..telqliyrse.srvvrhvqflswpdhGvpsdledlvrfqaqvcscc..iavpmml...............al

VKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
|.   .....  | .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.   .
vemftamvflqleslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfe

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 915-1132 1.6e-34 114.1 In-house 7-221 (439) alignment
Range on Protein: 915-1132
Range on HMM: 7-221/439.0
FGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGL--TPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSKTV
| | | . . . .| ||. | ...| . |...   |     ..  ||. ... .|  |..|. | |       |||| |..|| |.  |||||||  .|.
fqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvph..shyinanyikGyyddklyiatqgpkkett

VDFWCLVWQERPPVIVMVTNVKEEGKvkcqqYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTL-LGSDQPPLMITQYHFTSWPDHGVPEYATSILQF
 ||| ||....   |||.||. |  |     ||| ..   ||  .|    .  | .|.|| ...     . .    . |.|...|||. ||  |. .|.|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

HRRIKN-EYKPTKGPMLVHCSV
 | |.  . |   ||..|||| 
lrainsandkeeygpvvvhcsa

0051429 (Phosphotyrosine protein) phosphatases II 984-1131 6.5e-32 106.6 In-house 4-158 (272) alignment
Range on Protein: 984-1131
Range on HMM: 4-158/272.0
NGYINACYVDGYsdeYQ------YIATQGPVSKTVVDFWCLvWQERPPVIVMVTNVKEEGKVKCQQYWP------------DSDTKDYGPFSVTLSDEQV
.||||| .|.||   ..      .....||   |. ||| | ....  .||..... | |..|| .|||            .  |  || ..|||  |..
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYAtsILQFHRRIKNeykptKGPMLVHCS
|. ||.|.. |||| | . .......|.|.|||||||. |  .|.. . . .     .||.|||||
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCs

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1132-1222 1.4e-30 101.1 In-house 190-280 (301) alignment
Range on Protein: 1132-1222
Range on HMM: 190-280/301.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|.|.|||.|   | |..|.|.|......  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.|  
vlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLe

subfamily_CG42327_pd Subfamily CG42327 952-1221 2.1e-30 100.5 In-house 26-301 (319) alignment
Range on Protein: 952-1221
Range on HMM: 26-301/319.0
PSNKLLNRFANIVVYDDNRIILRPIsGHKDcPNGYINACYVDGYSDE-YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDT
.. |  .|..|.|   . |..|. | | .|  . |..| || || |   .|||.| .  ..  ||| .||. .  ||| .|.. | |  .| .|.| ..|
vtskdksrvinvvPlPetrvvlqri.gddd.kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket

KD----YGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpPLMITQYHFtSWPDHGVPEYATSILQFHRRIKNE---YKPTKGPMLVHCSVTQFQVTNWDS-
 |    || . ||| . .|  .|.|  . |  .  ..    .| | .  |.. .||   ....    ....    |   .   | . |.|     . |. 
ldntslyGdilvtlkgrevkdryaistlllkrvdkee.srelthywy.kwleaevPaeeaaliamllevrsslksysleqanelreksatletsmdadgs

TGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTV
  |. .  .  .  .   |. ..  .  .|||||| |||. .  |.  .|.. ..    .|. |.. | | ..  .|.|.
kaeagstssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltk

subfamily_ptpA1_pd Subfamily ptpA1 922-1132 7.5e-29 95.7 In-house 15-238 (418) alignment
Range on Protein: 922-1132
Range on HMM: 15-238/418.0
GHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSdEYQYIATQGPVSKTVVDFWCLVWQ
 |.|     |..| .|.       .. |    |   ||..||.  .  |. |. |  ..   . |||| |.||     |.|.||||. .|. ||| .||.
nhikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkeg..sdyinanyidgay.pkqfictqgplpntiadfwrmvwe

ERPPVIVMVTNVKEEGKVKCQQYWPDSD-----------TKDYGPFSVTLSDE--QVLTEYIIRKIHLTLLGSDQpplMITQYHFTSWPDHGVPEYATSI
.|  .|||..   |. ..||..|||.              . .| .|| | .   .   | | |.|.||. |  .    ||||..  |||| .|...  .
nrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetr...ditqyqyegwpdhnipdhtqpf

LQFHRRIKNEY---KPT---KGPMLVHCSV
 |. . | |      |.   . |..|||| 
rqllhsitnrqnqiipssdrnvpiivhcsa

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 941-1190 1.6e-28 94.5 In-house 36-284 (350) alignment
Range on Protein: 941-1190
Range on HMM: 36-284/350.0
ESDHTATVGLTPSNKllNRFANIVVYDDNRIILR----P--ISGHKDCPNGYINACYVDGY------SDEYQYIATQGPVSKTVVDFWCLVWQERPPVIV
  |   . |.    |  ||. ||. |. .|..|.    .     |   .| |||| |.           ...|||||.|. .|| ||. .. .   .||.
snDvilseGvelfak..nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvil

MVTNVKEEGKVKCQQYWPDSDTKDygpFSVTLsdeqvlteyiiRKIHLTLLGSDQPPLMITQYHFTSW------PDHGVPEYATSIlQFHRRIKNeykpt
..|.  | .  ||..||.. . .|   . | |              .    | ..  |. .. . ..        |. .... . . .      .     
sltsdvelnlekcyrYWqegsydd...itvkl...........askwenimgindsslysadvkkeasdndnisddndlkdnnslt.aitlaasd.....

kgPMLvhcsVTQFQVTNWDSTGEVKNPQTILMIME--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAAT
  |.     | |.|| ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....   
..Pyv....vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDs

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 957-1132 5e-28 92.6 In-house 59-225 (290) alignment
Range on Protein: 957-1132
Range on HMM: 59-225/290.0
LNRFANIVVYDDNRIILRpisghKDCPNGYINACYVDGYSDeyQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTK--DYG
 ||. ..|  |  |.||.        .  |. | ||.|      .| |||.. .||.|.| .| ||.  .|||. .. |.|| ||.||.|. . .   .|
knrykdvvcndktrvilk.....dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

PFSVTLSDEQVLTEYIIRKIhLTLLGSDQP-PLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSV
 ..|. | |.   . ||.|. |..   |.    ..  ..  ||||. |.  . ..|.  | ...    . ||. |||| 
eitvlcseeddkdaniikkt.lsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsa

0041856 (Phosphotyrosine protein) phosphatases II 954-1131 1.6e-27 91.6 In-house 1-117 (182) alignment
Range on Protein: 954-1131
Range on HMM: 1-117/182.0
NKLLNRFANIVVYDDNRiilrpisghkdcPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTnvkeegkvkCQQYWPdsdtkdy
|. .||. .|. || .|            .. |||| ...|.    ..||||||  .|| ||. ......  .||..|         . .|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

gpfsvtlsdeqvlteyiirkihltllgsDQPPLMITQYHFTSWPDHGVPEyATSILQFHRRIKNeykpTKGPMLVHCS
                            .  . ...||....|||||||.   ..|.| .....     .|| |||||
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCs

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 917-1132 4.8e-27 89.5 In-house 11-228 (305) alignment
Range on Protein: 917-1132
Range on HMM: 11-228/305.0
EFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILrpisgHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFW
.|| .   || .|....|. .   .  .         ..  ||. ..   |.||. |     .   |  || | ||   ..  ..| || |. ||  |||
kfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl.....egpwpheyihanyvstptnpkrfictqaplektcadfw

CLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDtKDYGPF-----SVTLSDEQ-------VLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEY
 . .|..   | |. |..| |  ||..|..  | ||   |      ...  |          ..  ...  |.. |. .  . .|.||.  ||| |||  
ymclqdkveaifmlcnllekgakkcleyfaskd.kdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaa

ATSILQFHRriknEYKPTKGPMLVHCSV
 ..||..      . .|.|||. |||| 
dlailelle....karpskgpivvhcsa

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1131-1221 4.9e-26 86.6 In-house 179-269 (305) alignment
Range on Protein: 1131-1221
Range on HMM: 179-269/305.0
SVTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|.|.|.|.|   | .. . ..| ..... ..|.|  .....||||..|||. .|.|    ....|.|.|.|||.|||  | .... ||| 
tvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 928-1132 4e-25 83.0 In-house 11-209 (281) alignment
Range on Protein: 928-1132
Range on HMM: 11-209/281.0
EGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVI
. ||..|  |        .||   | |.  ||..|| . |  |. |.     |.    || | |.     .  || ||||  .|  ||| ..|||    |
ddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnkns.tdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMVTNVKEEGKVKCQQYWPDSD--TKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgP
||. .. |  . || .|.|       ..  .||.  |  |    .  .. |.  |  .   .||.. .  |||  ||| .  .|.  |.|.        |
vmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetr...lithwlwkewpdwqvpessevmlkilrkirarst....p

MLVHCSV
 ..||| 
pvihcsa

0036282 (Phosphotyrosine protein) phosphatases II 984-1131 4.2e-25 83.9 In-house 2-112 (174) alignment
Range on Protein: 984-1131
Range on HMM: 2-112/174.0
NGYINACYVDGYSDEYQYIATQGPVSktvvdFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDsdtkdygpfsvtlsdeqvlteyiirkihltllGSDQ
. |||| ..|..     .||.||| .     || ......  ..||... || |..|| .|||.                                 .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

PPLMITQYHFTSWPDHGVPEYATsILQFHRRIKNEYKP-TKGPMLVHCS
.  .. ||... |||||||. .. .|.| ..... ..   .||.|||||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCs

0049772 (Phosphotyrosine protein) phosphatases II 942-1131 6.1e-25 84.0 In-house 34-220 (314) alignment
Range on Protein: 942-1131
Range on HMM: 34-220/314.0
SDHTATVGLTPSNKLLNRFANIVVYDdNRIILrPISGHKDcpNGYINACYVDGYsdeYQYIATQGPVSKTVVDF----------WCLV--WQERPPVIVM
...| .|.  . |.  ||. .|. .| || || |  ....   .|||| ||||.    ..|||||| . |||||          | .|  .. .. .|||
peltilvadlflnrdknryldilpad.nrvil.pglpvsg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------VTNVKEEGkvkcqQYWPDSDTKDYGpfsvtlsdeQ-------VlteyiirkihltllgsdqpPLMITQYHFTSWPDHGV
                      ... . |      ... .| ...          .       .                   . .. .|. . .||...
srdevladelsrLdaAlgKtpllildgng.....neptaadlellk.........eelydpelf...................erlgikylripvpDgsa

PeYATSILQFHRRIKNEykPTKGPMLVHCS
|     ...| . |..   ...|| ||||.
p.lledfdeflefieea..dkggpvlvHCk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 917-1133 2.5e-24 80.4 In-house 16-233 (310) alignment
Range on Protein: 917-1133
Range on HMM: 16-233/310.0
EFVANGHVKGNEGFKNQFMMLDSgESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRpIsgHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFW
.|.      | ||. .|.  ||. . | . |      .   ||....|. |. |. |. |   |   . || | ||        .| .|||. .|..|||
nfiiateklgieglvkqyrklda.kqdssltyeaykkymhknrysdvvcldtsrvklk.i..dksryedyihanyvktnylrstficsqgplqhtiidfw

CLVWQERPPVIVMVTNVKEEGKVKCQQYWPDS-DTKDYGPFSVTLSDEQVlTEYIIRKIHLTLLGS-----DQP----PLMITQYHFTSWPDHGVPEYAT
 ...|||   |... .| |||. ||  |||    |. ||   ||   |    |. | .. .|..       .||     | ..  ..  ||| |||.   
rmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc

SILqfHRRIKNEYKptKGPMLVHCSVT
  .   .|.  . .  .|| .||||  
htv..pqrllaqvr..hgpcvvhcsag

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 927-1132 4.6e-24 80.0 In-house 15-218 (307) alignment
Range on Protein: 927-1132
Range on HMM: 15-218/307.0
NEGFKNQFMMLDSGESDhTATVGLTPSNKLLNRFANIVVYDDNRIILRpISGhkdCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPV
 . ....| .|   . . . ||    .|   ||. .. . | .||... ..|       || | |.    .  ..|..|||  .|. .||... ||.   
vqalvdefrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvk.fdg...lasdyihanylgiaikpkkficaqgplentqysfwamaiqekves

IVMVTNVKEEGKVKCQQYWPDSD--TKDYGPFSVTLSDEQVLT------EYIIRKIHLTLLGsDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
..|. .| | .|.||.||||  .  .. .|  . |.| ... .      | .|    | .    |    |... .. |||.|||.   . . .   .. .
vimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltainlleavryd

ykptKGPMLVHCSV
    . |..|||| 
....tnpvvvhcsa

0046846 (Phosphotyrosine protein) phosphatases II 982-1131 5.6e-24 80.3 In-house 10-117 (176) alignment
Range on Protein: 982-1131
Range on HMM: 10-117/176.0
CPNGYINACYVDGYsdeyQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDsdTKDYGPfsvtlsdeqvlteyiirkihltllgs
 .  |||| ...|.     .||||||. .|. ||. ......  ..|..|. .| |..|| .|||.   ...|                           
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..........................

dqpplmitQYHFTSWPDHGVPEYaTSILQFHRRIKNEYKPTkGPMLVHCS
        ||... |||||||.. . .|.. . |.. .|   || |||||
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCs

0043147 (Phosphotyrosine protein) phosphatases II 984-1131 8e-23 76.4 In-house 5-108 (172) alignment
Range on Protein: 984-1131
Range on HMM: 5-108/172.0
NGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVkeegkvkcqqywpdsdtkdygpfsvtlsdeqvlteyiirkihltLLGSDQ
. |||| |.|.|    ..|||||| . |. ||| .....   .||..|.                                             |.  ..
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpel

PPLMITQYHFTSWPDHGVPeYATSILQFHRRIKN-EYKPTKGPMLVHCS
   .. ||....|||||||  .  .|.| . |..   .  .||.|||||
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCs

0049260 (Phosphotyrosine protein) phosphatases II 991-1131 1.6e-22 75.2 In-house 1-97 (152) alignment
Range on Protein: 991-1131
Range on HMM: 1-97/152.0
YVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWpdsdtkdygpfsvtlsdeqvlteyiirkihltllgsdqpplmitQ
..|||   ...|||||| . |. ||| ....    .|||.|.  | ||.|| ||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCS
|... |||||||. .  .|.... |.  ..  .|| |||||
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCs

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 944-1131 3.1e-22 73.9 In-house 21-200 (267) alignment
Range on Protein: 944-1131
Range on HMM: 21-200/267.0
HTAT--VGLTPSNKLLNRFANIVVYDDNRIILRPISGHkdcpngYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEgkvKC
 ..|    ..  |.  ||. . . |||.|.|||           |||| ||.||  . ..|.||.|...|. ||. .. ... ||||..|.| ..   . 
tsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...ni

QQYWPDS--DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLlgSDQPPLMITQYHFTSWPDHGVPE-YATSIlqFHRRIKNEYKPTKGPMLVHCS
...||    ..| |  ..|  | |.   .| |  . | .   ..    .| |..  |      . |   .  |    ||. .    |..|.||
rlfwPPkmgqakkyqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacs

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1132-1221 5.8e-22 73.3 In-house 187-276 (298) alignment
Range on Protein: 1132-1221
Range on HMM: 187-276/298.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| |...|.| . |. .| ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| 
vrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1132-1221 8e-21 69.2 In-house 164-252 (283) alignment
Range on Protein: 1132-1221
Range on HMM: 164-252/283.0
VTQFQVTNWDSTGEVKnPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. .|| .| . ||   .   |. .. .   |..  .. |||||| ..||.|.|.||...... .|| |.|||.|.|  | |... ||| 
lahyqvidWleygeqa.iinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl

subfamily_PTPRD_pd Subfamily PTPRD 1132-1220 2.1e-20 67.9 In-house 179-266 (564) alignment
Range on Protein: 1132-1220
Range on HMM: 179-266/564.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
|.||. |.| ..|  ......| ..... ... ....  ||||||  |||. .|..    ... |.|...|..|..|  | |..  |||
VrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt

Y_phosphatase Protein-tyrosine phosphatase 1132-1221 4.4e-20 67.5 Pfam-A 135-223 (235) alignment
Range on Protein: 1132-1221
Range on HMM: 135-223/235.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|...|||   |  ..|. .| ..... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
vkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

Y_phosphatase Protein-tyrosine phosphatase 1132-1221 4.4e-20 67.5 In-house 135-223 (235) alignment
Range on Protein: 1132-1221
Range on HMM: 135-223/235.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|...|||   |  ..|. .| ..... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
vkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 953-1133 1.1e-19 65.6 In-house 34-213 (285) alignment
Range on Protein: 953-1133
Range on HMM: 34-213/285.0
SNKLLNRFANIVVYDDNRIILRpisghkDCPNGYINACYVDG-YSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDS--D
.|  |||.|.. . .. |..|.      .    || | ..     |.  ||.||||. .|. ||| ...||.   ..|.  . | |  ||  |.|.   .
anpdlnryadvrcieetrvvlk......nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

TKDYGPFSVTLSD--EQVLTEYIIRKIHLTLL-GSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKGPMLVHCSVT
   .| . .||..  |. ..  |.  . ..    .   || . . .   |||.  || |  ...... .|.  .| . |. ||||  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsag

0050432 (Phosphotyrosine protein) phosphatases II 1132-1222 1.1e-19 66.4 In-house 199-286 (308) alignment
Range on Protein: 1132-1222
Range on HMM: 199-286/308.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
||.|. |||   |   .|. .| ..|.. ...   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||. 
vthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 957-1132 1.4e-19 64.9 In-house 58-230 (305) alignment
Range on Protein: 957-1132
Range on HMM: 58-230/305.0
LNRFANIVVYDDNRIILrpisgHKDCPNGYINACYVDG-YSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGP
 ||.... . | . . |     .|  |  || | ||      | ..|..|||. .|. .|| .| |..   |||. .  | ||.|| |||| .  .    
knryqdvpcqdqsavkl.....dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

FSV----TLSDEQVL---TEYIIRKIHLTLlgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSV
 |      .|  . .   .|  |  ..||   | .  . . . ..| ||| |||    . |..   |.     .| |..|||| 
ksgivvenvsgskpmerdaeiqitllnlty..sgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsa

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1132-1220 1.4e-19 65.3 In-house 177-265 (318) alignment
Range on Protein: 1132-1220
Range on HMM: 177-265/318.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
| |...|.|  .|  ... ..| .. .  ..|.| |.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  |||
vrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt

0051082 (Phosphotyrosine protein) phosphatases II 984-1131 2.7e-19 64.7 In-house 3-100 (151) alignment
Range on Protein: 984-1131
Range on HMM: 3-100/151.0
NGYINACYVDGYsdeyqYIATQGPVSktvvDFWCLVWQERPPVIVMVTNVKEEGkvKCQQYWPDSDtkdygpfsvtlsdeqvlteyiirkihltllgsdq
..|||. ||.|.     .....|| .    ||. |....   .||.... .| |  .| .|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

ppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykPTKGPMLVHCS
  . ........|||.|.|..  ..|.|.. . .   . .||.|||||
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCs

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1132-1221 2.9e-19 64.3 In-house 139-228 (250) alignment
Range on Protein: 1132-1221
Range on HMM: 139-228/250.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| |.. ..|   |  .. ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |.| |.|||.|.|  |...|..|.. 
vrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesl

0046845 (Phosphotyrosine protein) phosphatases II 1132-1222 5.4e-19 64.1 In-house 167-261 (284) alignment
Range on Protein: 1132-1222
Range on HMM: 167-261/284.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVV
||.|..|.|   |   .|. .| ..... . ...  |.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||. 
vthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle

0051299 (Phosphotyrosine protein) phosphatases II 1132-1221 5.9e-19 64.0 In-house 184-272 (288) alignment
Range on Protein: 1132-1221
Range on HMM: 184-272/288.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
||.|..|||   |   .|. .| ....... ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||.
vthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

0036941 (Phosphotyrosine protein) phosphatases II 1132-1221 6.5e-19 63.8 In-house 170-263 (297) alignment
Range on Protein: 1132-1221
Range on HMM: 170-263/297.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTV
||.|..|.|.  |   .|...| ..|.. . ...  ... ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||.
vthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1132-1221 7.1e-19 63.0 In-house 180-269 (319) alignment
Range on Protein: 1132-1221
Range on HMM: 180-269/319.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|..|| |.|   .  .. ...| ..... ....|  .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||. 
vkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp

0047943 (Phosphotyrosine protein) phosphatases II 1132-1221 1.4e-18 62.8 In-house 168-258 (273) alignment
Range on Protein: 1132-1221
Range on HMM: 168-258/273.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
||.|..|.|   |   ... .| ..|.. .....  .|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||.
vthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp

PTPc_DSPc_SM00012 1132-1221 1.6e-18 62.2 In-house 2-93 (105) alignment
Range on Protein: 1132-1221
Range on HMM: 2-93/105.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTV
|.....|.|  .|  .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 987-1131 1.9e-18 61.3 In-house 78-222 (301) alignment
Range on Protein: 987-1131
Range on HMM: 78-222/301.0
INACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSD--TKDYGPFSVTLSDEQ-VLTEYII-RKIHLTLLGSD
| | ...   .  ..||||||...|  ||| .. |     |||...  |. . ||..| | .   . | | |.... ... .| . |. |.....    .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

QPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCS
 ..  .| | ...|.|.|||.  . . ..   .|.    .. |..||||
fatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcs

0040438 (Phosphotyrosine protein) phosphatases II 1132-1221 2.1e-18 62.1 In-house 174-262 (317) alignment
Range on Protein: 1132-1221
Range on HMM: 174-262/317.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
||.|. |.|.  |  ..|...| ..|.. . .. .... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| 
vthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp

0044763 (Phosphotyrosine protein) phosphatases II 966-1131 2.8e-18 61.7 In-house 2-118 (178) alignment
Range on Protein: 966-1131
Range on HMM: 2-118/178.0
YDDNRIILRPISGHKDCPngYINACYVDGYsdeyQYIATQGPvsktvVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTkdygpfsvtlsdeqv
.|..| .| ...|.  ..  ||||......     |.....|     .|.. |....   .||..|. .| |..|| .|||..                 
ldrtrvllsnleglersd..yinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

lteyiirkihltllgsdqpplmiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCS
                        ||... .||||||.    .|.|.. |.. ... .|| |||||
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCs

subfamily_PTPRA_pd Subfamily PTPRA 1132-1222 3.4e-18 60.6 In-house 193-282 (330) alignment
Range on Protein: 1132-1222
Range on HMM: 193-282/330.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|.||  | |   |   .|. .| ..... ..... .. .||||||  |||.  |..  . ... |.|...|||...|. | |.|  |||  
vrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtde

DSPc_SM00195 1132-1221 5.2e-18 60.7 In-house 160-248 (263) alignment
Range on Protein: 1132-1221
Range on HMM: 160-248/263.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|||.|..||   |  .... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
vtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

PTPc_SM00194 1132-1221 5.2e-18 60.7 In-house 160-248 (263) alignment
Range on Protein: 1132-1221
Range on HMM: 160-248/263.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|||.|..||   |  .... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
vtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

0045450 (Phosphotyrosine protein) phosphatases II 1132-1221 8.5e-18 60.6 In-house 197-290 (307) alignment
Range on Protein: 1132-1221
Range on HMM: 197-290/307.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
||.|. |.|  .|  ......| ..||. . ...  ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||. 
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

0039614 (Phosphotyrosine protein) phosphatases II 1132-1221 3.7e-17 58.2 In-house 185-275 (297) alignment
Range on Protein: 1132-1221
Range on HMM: 185-275/297.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
||.||.|.|   |   .....| ..|.. . ...  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| 
vthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp

0042113 (Phosphotyrosine protein) phosphatases II 1132-1221 7.8e-17 57.0 In-house 140-229 (245) alignment
Range on Protein: 1132-1221
Range on HMM: 140-229/245.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.... ..|.  |.  .....| ..|.. . ... .|. ..||||. |||...|.|| . ..  ..|. .......|  | |.||.||| 
vihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtp

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 999-1134 1.3e-16 55.3 In-house 5-146 (199) alignment
Range on Protein: 999-1134
Range on HMM: 5-146/199.0
YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPD--SDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPP-LMITQYHFTS
 .||||| |. .|. ||| .||.     |||| . . . ..    |||   | |  || .|||     .  .| |  . ||   .  |    |..| |||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSVTQ
| ..  |. |    ..   | . . |.  |  |..||||  |
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 999-1134 1.4e-16 55.2 In-house 4-145 (198) alignment
Range on Protein: 999-1134
Range on HMM: 4-145/198.0
YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPD--SDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPP-LMITQYHFTS
 .||||| |. .|. ||| .||.     |||| . . . ..    |||   | |  || .|||     .  .| |  . ||   .  |    |..| |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSVTQ
| ..  |. |    ..   | . . |.  |  |..||||  |
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgq

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 953-1131 2e-16 54.8 In-house 42-212 (288) alignment
Range on Protein: 953-1131
Range on HMM: 42-212/288.0
SNKLLNRFANIVVYDDNRIILRpisghkDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKD
.|   .|. |.   |  |. |       | |. ||.|  |     . . | .| |.  |.  .| .. ..    |||.... | || | ..|.|    . 
anptrdryenlprcditrvkls......ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

yGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQP---PLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCS
   .    .. ..  . | . ....||   ..   . .. . |.  |.|.||||   | |..  ..|.  |    |..||.|
.arigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....Pivvhss

0043336 (Phosphotyrosine protein) phosphatases II 1132-1221 3.6e-16 54.9 In-house 175-263 (278) alignment
Range on Protein: 1132-1221
Range on HMM: 175-263/278.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
||... ..|   |   .....| ..... . ..   |. ..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.||| 
vthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp

subfamily_egg_pd Subfamily egg 953-1221 8.1e-16 52.6 In-house 39-256 (307) alignment
Range on Protein: 953-1221
Range on HMM: 39-256/307.0
SNKLLNRFANIVVYDDNRIILRPISGHkdCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEgkVKCQQYWPDSDT--
 |.   |   .   |  |. |.   |     . .| | .|.|     ..| .| |.  || ||| .|.||. . |||.|  ||    .|. ||| ...  
nnlekarskrvhckdssrvklelrrGq..ylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

KDY--GPFSVTLSDEQVLTEYIIRKIHLTLLGSDqpplmitqyhftswpdhgvpeyatsilqfhrrikneykptkgpmLVHCSVTQFQvTNWDSTGEVKN
  .  | . ..  . .  .. . |  .| |.|.|                                                 .  .|  ... ...|  
lvtvpGslrienlkvdskadplfrvtklklvGgd............................................deerflehwq.gdvnnssdvys

PQTILmimeemyRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTV
|  .|       |  |.   . .||.. . | ..| . |. ... .    | |  . ||..    | ... ||..|
plrvl.......rklrnl.skpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesv

0040439 (Phosphotyrosine protein) phosphatases II 1132-1221 2e-15 52.6 In-house 142-232 (249) alignment
Range on Protein: 1132-1221
Range on HMM: 142-232/249.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|...|.|.|  .|  ......| ..|..   ...   .. ..||||. |||...|.|| . ..  ..|. .|.....|  | |.||.||. 
vlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp

0045098 (Phosphotyrosine protein) phosphatases II 1132-1221 3.6e-15 51.6 In-house 156-258 (278) alignment
Range on Protein: 1132-1221
Range on HMM: 156-258/278.0
VTQFQVTNWDSTGEVKNP--QTILMIMEEMYRTQR------------KRGNTSIVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-
||... ..|.  |   .|  . .| ..|.. . ..              ... ..||||  |||.....|| . .  .  ||..|.....|  | |.|| 
vthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpgl

SVQTV
.||. 
avqnl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1154-1221 9.9e-15 49.2 In-house 178-245 (267) alignment
Range on Protein: 1154-1221
Range on HMM: 178-245/267.0
MIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 ..  . . | . ||  .||.||| ||||  |  . . ... ||||| |.|. |.  | |..| |.| 
plfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk

subfamily_Ptp69D_pd Subfamily Ptp69D 1132-1221 1.6e-14 48.8 In-house 184-272 (307) alignment
Range on Protein: 1132-1221
Range on HMM: 184-272/307.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|.. |.|. .   . ....| ..|...  ...  .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  ||  
vvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsl

subfamily_PTPRK_pd Subfamily PTPRK 1132-1221 1.9e-14 48.2 In-house 175-263 (314) alignment
Range on Protein: 1132-1221
Range on HMM: 175-263/314.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| ||| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||. .|.| .. ..  ..|||.|||.. |. | .|.  |.| 
vrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvete

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1131-1225 2.2e-14 48.6 In-house 150-245 (284) alignment
Range on Protein: 1131-1225
Range on HMM: 150-245/284.0
SVTQFQVTNWDSTGEVKNPQTILMIMEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
...||    |   |  . |  ......   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  .
kirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1131-1224 2.9e-14 48.1 In-house 186-280 (319) alignment
Range on Protein: 1131-1224
Range on HMM: 186-280/319.0
SVTQFQVTNWDSTGEVKNPQTILMIMEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSV
..|||    |   |  . |  ......   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  
kitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1131-1222 3.3e-14 47.8 In-house 179-275 (325) alignment
Range on Protein: 1131-1222
Range on HMM: 179-275/325.0
SVTQFQVTNWDSTGEVKNPQTILMIMEEMYR---TQ--RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|| |||.  ||  |  | | |.. |.. .     .     .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.|| 
svkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1132-1220 3.8e-14 46.7 In-house 174-261 (515) alignment
Range on Protein: 1132-1220
Range on HMM: 174-261/515.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
||||. |.|   |  |. ...| .. |. .... . . ....|||  |||  .....   . . ||  ..|||....  | ..|  |||
vtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqt

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 955-1132 4.1e-14 47.0 In-house 44-218 (312) alignment
Range on Protein: 955-1132
Range on HMM: 44-218/312.0
KLLNRFANIVVYDDNRIILrpiSGHKdcpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSdtKDYg
| |||. || ..|  |. |   .| .   | || | .|   .   ....||||. .|.. || |.       |.... . |.|  || .|  |     . 
kdlnrypniqcwdrgrftl...agde...nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi..vgf.

pfsVTLSDEQVLTEYII-------------RKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSV
   | | | .| |||                ..   .. .      . .| ..||||||.|.   . |..   .|..    | |.. ||| 
...vdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkd....kkpviahcsa

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1132-1220 4.4e-14 47.1 In-house 175-262 (315) alignment
Range on Protein: 1132-1220
Range on HMM: 175-262/315.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
||||| |.|   |  |.  ..| .. |.    ... . |..||||  |||. .....   ... | . ..|||...|  | ..|  |||
vtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt

0036282 (Phosphotyrosine protein) phosphatases II 1132-1220 1e-13 46.8 In-house 69-155 (174) alignment
Range on Protein: 1132-1220
Range on HMM: 69-155/174.0
VTQFQVTNWDSTGEVKNPQtILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQT
. |.. ..|.  |.   .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||
giqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

0037934 (Phosphotyrosine protein) phosphatases II 1132-1221 1.3e-13 46.6 In-house 135-228 (243) alignment
Range on Protein: 1132-1221
Range on HMM: 135-228/243.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTV
|.... ..|   |   .|. .| ...|..  ...        ..  ..||||  |||.....|| . . ..   | .|.....|  | |.|| .||| 
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtp

fn3 Fibronectin type III domain 501-571 1.9e-13 43.5 Pfam-A 12-84 (85) alignment
Range on Protein: 501-571
Range on HMM: 12-84/85.0
NPDAINIVWKIPTVPNGIITVYEIKYRESTSTG-PYNITNTTNT-YYNIAGLIPNTSYTIGVRAYTSIGPGEW
... ... |. |. ..| || ||..|||..... . ..|.. .|  ... || |.|.|.. |.|..  | |..
tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1132-1221 2.5e-13 44.8 In-house 179-270 (297) alignment
Range on Protein: 1132-1221
Range on HMM: 179-270/297.0
VTQFQVTNWDSTGEVK--NPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| |.| ..| .  . .  . ...| ...|.  .  .. .. ..|||.  ||| .....    . . | |  .|.|...|  | ..|  ||| 
vkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1132-1223 2.6e-13 44.6 In-house 177-267 (315) alignment
Range on Protein: 1132-1223
Range on HMM: 177-267/315.0
VTQFQVTNWDsTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
| |...| |  . .| .  . || .    .  ..   ..||||||. |||.  |..  . ... ..| .|||.....  | .. . ||..  
vvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeq

I-set Immunoglobulin I-set domain 802-888 3.4e-13 41.2 Pfam-A 1-90 (90) alignment
Range on Protein: 802-888
Range on HMM: 1-90/90.0
PVIEEFPNDVTTEEGREVLLKVKVNETTKLCFNWYHNGDPVTEDYAHELRGDG---SLLLVSVEEKHKGAYRFVANNDAGTVSQQVVLTV
|.... ..||...|| .| |...|... .. ..|...| .....  .... ..   .| . .||.. .| |. .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1132-1224 3.5e-13 44.3 In-house 172-265 (281) alignment
Range on Protein: 1132-1224
Range on HMM: 172-265/281.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVSV
|.|.. |.|  .|  .... .|   .|......|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||||  
veqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1009-1131 4.5e-13 43.9 In-house 38-156 (255) alignment
Range on Protein: 1009-1131
Range on HMM: 38-156/255.0
SKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTL-LGSDQPPLMITQYHFTSWPDHGVPEYATS
| ||  |.  . | .. |.||... .|||..||..|.|    .      |...  .  .. ..| ...|. ||  .    .. |... |...  || |  
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

ILQFHRRIKNEyKptkgPMLVHCS
||.  . ...  |    ...||||
ilnilkvvrds.k....svvvhCs

fn3 Fibronectin type III domain 394-477 4.9e-13 42.2 Pfam-A 2-83 (85) alignment
Range on Protein: 394-477
Range on HMM: 2-83/85.0
PVDDIIFSSVESVSMTVSWDEAPcnGRNGPITGFYLTYTNITSNT-SYTINITGGDNrMYNLTGLIPYTNYTVSIIPYNYNMNGP
.. .. .|.| | |.|.||.. .   ..|||||. ..| . ...  . ......  .  ..|||| |.|.|....  .| . .||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1132-1222 9e-13 42.9 In-house 177-266 (288) alignment
Range on Protein: 1132-1222
Range on HMM: 177-266/288.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.||.| . |  .|  .. . .| ... .  .. .     |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||. 
itqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 965-1131 9.4e-13 42.9 In-house 29-199 (290) alignment
Range on Protein: 965-1131
Range on HMM: 29-199/290.0
VYDDNRIILRPIsgHKDCPNGYINACYVDgYSDEYQYIATQGPVSKT-------VVDFWCLVWQERPPVIVMVTNVKEEGKV----KCQQYWPDSDT--K
.  ..|..|.     |   ..|| | .|  ...  . |.|| |  |.       . .|| .. ||.   .||. ...|. .      |..| |.|     
LveatrvvLkgy..gkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel

DYGPFSVTLSDEQVLTEYIIRKIHLTLlgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCS
 .. ..|   .     . ..|.. ..    |. .. .| . . .| .  |.|   ..|.  . .|..    | |..||| 
kfkgltvkCkskekeddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcv

subfamily_PTPN23_pd Subfamily PTPN23 1132-1225 9.4e-13 42.6 In-house 173-270 (288) alignment
Range on Protein: 1132-1225
Range on HMM: 173-270/288.0
VTQFQVTNWDSTGEVKNPQTILMIMEEM---YRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
|.  |.|.| . |  . |.|.| ...|.   |...... .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||..  ..
vshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk

subfamily_PTPRB_pd Subfamily PTPRB 1132-1222 1.1e-12 42.7 In-house 181-272 (293) alignment
Range on Protein: 1132-1222
Range on HMM: 181-272/293.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQ-RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|.|.. | |   |  ....|.| ..... ... ..  .. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||. 
vrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtek

subfamily_PTPN12_pd Subfamily PTPN12 1132-1221 1.2e-12 42.3 In-house 172-263 (290) alignment
Range on Protein: 1132-1221
Range on HMM: 172-263/290.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
|.||. |.|   |  ......| ..|.. |. ... .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  ||| 
vyqfhYtaWPDhgvPssaksllelielv.relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtk

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 950-1064 1.6e-12 41.6 In-house 92-199 (244) alignment
Range on Protein: 950-1064
Range on HMM: 92-199/244.0
LTPSNKLLNRFANIVVYDDNRIILrpiSgHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEgkvkcQQYWPDSD
. |.|   || .  . .| ||. |   | .    | |||| .|       .|| || |.. | .||| .. .    |.|..  |.||     ..|||||.
fnpnnswknregaglpfdfnrvpl...s.kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse

TKDYG--PFSVTLSDEQ
  ..     .|||.| .
plewyeeditvtltdrd

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1132-1221 1.6e-12 42.1 In-house 163-254 (274) alignment
Range on Protein: 1132-1221
Range on HMM: 163-254/274.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|. .  |.|  .   ....|.| ...|. ...... .   ..|||||  .||  .| |.  .... . |.|.||...    |... | ||| 
vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts

subfamily_CG7180_pd Subfamily CG7180 1132-1221 1.7e-12 41.6 In-house 182-276 (296) alignment
Range on Protein: 1132-1221
Range on HMM: 182-276/296.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRG-----NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|..||.| |..  .|    . |. . .. |. |..      .  .||..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..|
vklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenv

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 911-1006 2.7e-12 40.7 In-house 6-95 (95) alignment
Range on Protein: 911-1006
Range on HMM: 6-95/95.0
PVGQFGEFVANGHVKGNEGFKNQFMMLDSgESDHTATVGLTPSNKLLNRFANIVVYDDNRIILrpiSGHKDcpNGYINACYVDGYSDEYQYIATQG
 |  |   | . | . .. | |.|  .    |  . ||| . .|   ||| ||. ||  |..|   . ..|    |||||.||||.    |||.||
hvsvfhshvlemhsnsdqefdnefksism.tsgapytvgsseanipknrflnifpydatrvvl...ttkrd..sdyinacfvdgyarkncyiaaqg

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 943-1049 3.4e-12 40.4 In-house 39-157 (349) alignment
Range on Protein: 943-1049
Range on HMM: 39-157/349.0
DHTATVGLTPSNKllNRFANIVVYDDNRIILR----PISGH-------KD-CPNGYINACYVD--GYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIV
|   . |.    |  ||. .|. |.  |..|.    .  .        .   .. |||| |.    .| | .||||| |.  || ||. ..  .. ....
dvilseGvelfak..nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvl

MVTNVKEEGKVKCQQYWPDSD
 ... ||..  ||..|| . .
sLnddkelslekcdiywqels

subfamily_PTPRG_pd Subfamily PTPRG 1132-1220 3.7e-12 40.2 In-house 185-272 (563) alignment
Range on Protein: 1132-1220
Range on HMM: 185-272/563.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
|.|.. |.|  .|  . .   |. ..   .....     ||||||  |||. ....  | ... ..| ...||..||  | |..  |||
vrqyhytkWPdhgvPehslpvLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt

0043147 (Phosphotyrosine protein) phosphatases II 1132-1230 8.5e-12 40.6 In-house 65-156 (172) alignment
Range on Protein: 1132-1230
Range on HMM: 65-156/172.0
VTQFQVTNWDSTGEVkNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVVSVQLYLPY
. |.. ..|.  |   ... .| ..| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||.    .. . .
giqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyf





subfamily_eak_pd Subfamily eak 960-1116 1.7e-11 38.1 In-house 57-208 (332) alignment
Range on Protein: 960-1116
Range on HMM: 57-208/332.0
FANIVVYDDNRIILRPisgHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSD--TKDYGPFS
  .|| || . . | .    .  ..|||||  ..      .|| |  .  . |  || .| ... | ||.. .  |..  | ..|.||      ..| . 
vvkivpydrylvrlts...sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VTLSDEqvLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYAtSILQFHRRIK
|.  .   . . |..   | |         .  |..  | .  .| |    | ... .|
verkef..vkrniletrllels.kGnethrvlhykvfGwtettlpkye.dflalrkvmk

PTPc_DSPc_SM00012 1088-1131 4e-11 38.4 In-house 2-47 (105) alignment
Range on Protein: 1088-1131
Range on HMM: 2-47/105.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK--GPMLVHCS
...||.|.||||||||...|||.. | .|....  .  .|..||||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCs

subfamily_hpo-7_pd Subfamily hpo-7 1010-1131 8.4e-11 36.2 In-house 45-162 (263) alignment
Range on Protein: 1010-1131
Range on HMM: 45-162/263.0
KTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTL-LGSDQPPLMITQYHFTSWPDHGVPEYATSI
.|.  |.  . | .. |.||... .|||..||..|.|    .      |...  .|  . ... ..|.  ||  .    ...| .. |...  || | .|
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LQFHRRIKNEyKPtkgpMLVHCS
|.  .  .|  |.    . ||||
lnilkvarns.ks....lvvhcs

subfamily_PTPN6_pd Subfamily PTPN6 1132-1223 9.6e-11 36.2 In-house 188-285 (306) alignment
Range on Protein: 1132-1223
Range on HMM: 188-285/306.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVVS
| |.. ..|   |  |.|...|  .|.. | |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | |||   
vfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqq

0048076 (Phosphotyrosine protein) phosphatases II 1053-1131 1.7e-10 36.2 In-house 13-89 (145) alignment
Range on Protein: 1053-1131
Range on HMM: 13-89/145.0
YGPFSvTLSDEQVLTEYIIRK-IHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTkGPMLVHCS
.|..  | .| . | .. |.  . ||   ..    ...||....|||||||. .  .|.| . |.. .|   ||.|||||
lgslp.taldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCs

subfamily_PTPN13_pd Subfamily PTPN13 1132-1220 3.9e-10 34.4 In-house 168-254 (273) alignment
Range on Protein: 1132-1220
Range on HMM: 168-254/273.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
|.... ..|   |  .... .| .. |. | |.   .. ||||||  .||| .. .  . ..  . .  .|| ..... | |. | |||
vahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqt

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1133-1226 6.1e-10 33.5 In-house 155-255 (270) alignment
Range on Protein: 1133-1226
Range on HMM: 155-255/270.0
TQFQVTNWDSTGEVK------NPQTILMIMEEMYRTQRKRGN-TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
. |. ..|   | ..      ... .| ..... |....  . . ..||||. |||. .. |  ....  .... .|| ....  | ...  ||... ..
vHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqye

L
.
f

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1133-1221 6.6e-10 32.9 In-house 92-180 (440) alignment
Range on Protein: 1133-1221
Range on HMM: 92-180/440.0
TQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 |..   |   |  |    .| .....  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| 
kqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 993-1064 7.7e-10 32.7 In-house 230-299 (440) alignment
Range on Protein: 993-1064
Range on HMM: 230-299/440.0
DGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEgkvKCQQYWPD-SDTKDYGPFSVTLSDEQ
.|||    .|||| |.  ||.||| || . |   |.|. ....     |  |||  . .  .|||.|     .
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgse

0049260 (Phosphotyrosine protein) phosphatases II 1134-1227 9.1e-10 33.9 In-house 56-142 (152) alignment
Range on Protein: 1134-1227
Range on HMM: 56-142/152.0
QFQVTNWDSTGEVKNPQTILMIMEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVVSVQLY
|.. ..|.  |  ...| .|.... . .  ... .  ..||||  |||.....||   .        ........  | ..||.|..    .. 
qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl

0041856 (Phosphotyrosine protein) phosphatases II 1132-1221 1.1e-09 33.6 In-house 79-157 (182) alignment
Range on Protein: 1132-1221
Range on HMM: 79-157/182.0
VTQFQVTNWDSTGEVKnPQTILMIMEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDVFQVLKSQRIQKPGSVQTV
..|.. ..|.  |    ....| ..||...      .  ..||||  |||.....||   . .    | .......|  | ..||.|.| 
giqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitp

0048076 (Phosphotyrosine protein) phosphatases II 1132-1221 1.1e-09 33.6 In-house 47-129 (145) alignment
Range on Protein: 1132-1221
Range on HMM: 47-129/145.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVLKSQRIQKPGSVQTV
..|.. ..|.  |.   ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......|.  | | ||.|...
giqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp

0048179 (Phosphotyrosine protein) phosphatases II 1085-1131 1.4e-09 33.4 In-house 46-91 (144) alignment
Range on Protein: 1085-1131
Range on HMM: 46-91/144.0
PLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCS
  ...||....|||||||.... .|.| . |.. ..  .||.|||||
eregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCs

subfamily_PTPRN_pd Subfamily PTPRN 1132-1223 1.9e-09 31.7 In-house 189-280 (297) alignment
Range on Protein: 1132-1223
Range on HMM: 189-280/297.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGnTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVS
||||    | ..|   .....|     . .. | |  ..||||||| .||. ....    .|.  |    ||.   |.  | |.|| |.|   
vtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdq

0048179 (Phosphotyrosine protein) phosphatases II 1133-1221 2.1e-09 32.8 In-house 50-131 (144) alignment
Range on Protein: 1133-1221
Range on HMM: 50-131/144.0
TQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTV
.|.. ..|.  |    .. .| ..| . . ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|.. 
iqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnp

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1132-1220 3.9e-09 30.4 In-house 280-370 (392) alignment
Range on Protein: 1132-1220
Range on HMM: 280-370/392.0
VTQFQVTNWDSTGEVKNP--QTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
|||.|   |   |  ...  ...| ..  .  .  .. . ||.|||    ||. .||.|   | .      .|.|| .|  | ..  .|||
vtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqt

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 954-1040 4e-09 30.4 In-house 34-117 (332) alignment
Range on Protein: 954-1040
Range on HMM: 34-117/332.0
NKLLNRFANIVVYDDNRIILRPISGHKDcpngYINACYVDGYSDEYQYIATQGPVS-KTVVDFWCLVWQERPPVIVMVTNVKEEGKVK
|  .||   . ..| .|. | |  |. |    . || .||||| .  || .| |.  .|   || .| . .| .|... .. |. | |
nmdmnriphlycfdhsrvelapqdgkdd....fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

0051429 (Phosphotyrosine protein) phosphatases II 1132-1222 4.3e-09 31.9 In-house 122-212 (272) alignment
Range on Protein: 1132-1222
Range on HMM: 122-212/272.0
VTQFQVTNWDSTGEVKNPqtILMIMEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------VFQVLKSQRIQKPGSVQTVV
|.... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        ......  | | ||.|||  
vmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqtee

subfamily_PTPN9_pd Subfamily PTPN9 1145-1220 6.2e-09 30.3 In-house 188-275 (297) alignment
Range on Protein: 1145-1220
Range on HMM: 188-275/297.0
EVKNPQTILMIMEEMYRT------------QRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
  .. ...| ..|.. ..            . .  .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.||
vPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqt

0046846 (Phosphotyrosine protein) phosphatases II 1134-1221 1.2e-08 30.4 In-house 78-159 (176) alignment
Range on Protein: 1134-1221
Range on HMM: 78-159/176.0
QFQVTNWDSTGEVKNpQTILMIMEEMYRTQRKRgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTV
|.....|.  |     . .| ..|.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.||| 
qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 983-1063 1.4e-08 29.1 In-house 12-89 (130) alignment
Range on Protein: 983-1063
Range on HMM: 12-89/130.0
PNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEgkvkcQQYWPDSDTKDYGPFSV--TLSDE
 | |||| .|       .|. || |...| .||| .. .    |.|..  |.||     ..|||||.  ..    .  ||.| 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr

subfamily_PTPN3_pd Subfamily PTPN3 1132-1221 1.9e-08 28.6 In-house 173-261 (280) alignment
Range on Protein: 1132-1221
Range on HMM: 173-261/280.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
..|.| ..|   |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  |.. .  ..  . . ....  | |.   |||.
ilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1006-1132 2e-08 28.1 In-house 98-230 (302) alignment
Range on Protein: 1006-1132
Range on HMM: 98-230/302.0
GPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTL-SDEQVLTEYIIRKI------HLTL-LGSDQPPLMITQYHFTS
 |  .|.  .|.|. | .  ..| .....|... || .|. |   ..  .| ..|.  | .. | |.  .|        ..     .. .  .   .|..
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPEYATSILQFHRRIkNEYKptkGPMLVHCSV
||||| |. | . |.  .   . ||     .|||||.
wpdhGapkeaytaldilkfc.esyk...knvlvhcsa

0051082 (Phosphotyrosine protein) phosphatases II 1132-1225 4.9e-08 28.2 In-house 60-143 (151) alignment
Range on Protein: 1132-1225
Range on HMM: 60-143/151.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVVSVQ
|.......|. .|   .....| ..|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||.    .
vlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 910-994 5.6e-08 26.5 In-house 6-85 (440) alignment
Range on Protein: 910-994
Range on HMM: 6-85/440.0
IPVGQFGEFVANGhvKGNEGFKNQFMMLDSGESDHTATVGLtPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDG
| | .| ..| |   .    |.... .| || |. .   .| |.||. ||. ||..|| .|..|  . |  |  . |||| |..|
iivadfadyvqnn..rrsrafedewsllpsglsqpsdiasl.pnnkvknryrnilaydhsrvmleevkgvpd..sdyinasying

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 958-1030 7.6e-08 26.2 In-house 41-116 (347) alignment
Range on Protein: 958-1030
Range on HMM: 41-116/347.0
NRFANIVVYDDNRIILRPIS---GHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMV
||  .  . |. |..| |     .. | ...|||| ..     . .|| || |. .|| ||| .|   .   .| .
nrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_PTPN1_pd Subfamily PTPN1 1132-1222 8.2e-08 26.3 In-house 164-258 (290) alignment
Range on Protein: 1132-1222
Range on HMM: 164-258/290.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQR-KRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVV
...|  | |   |  . |.. |  . .. ..   ..     |.|||  .|||  || . | .    | .    .|. .||   | .. | .||  
ilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtad

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1132-1221 2.9e-07 24.9 In-house 139-227 (239) alignment
Range on Protein: 1132-1221
Range on HMM: 139-227/239.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| |...| |   |  .   ..| .  .. . .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
vyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1132-1221 2.9e-07 24.9 In-house 138-226 (239) alignment
Range on Protein: 1132-1221
Range on HMM: 138-226/239.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| |...| |   |  .   ..| .  .. . .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
vyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1132-1227 4e-07 24.1 In-house 183-271 (301) alignment
Range on Protein: 1132-1227
Range on HMM: 183-271/301.0
VTQFQVTNWDSTGEVKNPQTILMIMEeMYrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVvsVQLY
|| .| ..|   |  |    .  .|| .     |. .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||.   |||
vthyqysewtdrgvPkshaelfdlme.lv....kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn..sqly

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1136-1223 4.2e-07 23.7 In-house 194-276 (302) alignment
Range on Protein: 1136-1223
Range on HMM: 194-276/302.0
QVTNWDSTGEVKNPQTILMIMEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
. . |   |  |...| | |.   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||.   
afsawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1088-1133 4.9e-07 23.4 In-house 91-137 (440) alignment
Range on Protein: 1088-1133
Range on HMM: 91-137/440.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSVT
. |||. .|||.|||..|  .|.. . ... . |  .||.|||||. 
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsag

0044763 (Phosphotyrosine protein) phosphatases II 1134-1220 5.8e-07 24.8 In-house 77-156 (178) alignment
Range on Protein: 1134-1220
Range on HMM: 77-156/178.0
QFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQT
|.. ....  |.   .. .| ..| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..
qylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1132-1220 6e-07 23.9 In-house 135-224 (237) alignment
Range on Protein: 1132-1220
Range on HMM: 135-224/237.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
. |.| | |   |  ..  ..| .  ..    ..    .  ..|||  |||...|    . . ..| . |.|... ..|   ..|  .||
ihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqt

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1133-1226 7.7e-07 23.2 In-house 171-268 (287) alignment
Range on Protein: 1133-1226
Range on HMM: 171-268/287.0
TQFQVTNWdsTGEVKNPQ---TILMIMEE--MYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQL
 |... .|    .|  |     | ....       .|.  .   .|||..  .||| .. |  . ... .  | .|| .|.   | .. . ||.|| ..|
kqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrl





0049772 (Phosphotyrosine protein) phosphatases II 1134-1230 7.7e-07 24.6 In-house 182-272 (314) alignment
Range on Protein: 1134-1230
Range on HMM: 182-272/314.0
QFQVTNWDStGEVKNPQTILMIMEEMYRTqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTeGVIDVFQVLKSQRIQKPGSvQTVVSVQLYLPY
..  ....  |..  .. .. ..| . .    . .. ..|||.. .||.. |..||  . ...   . .... ....|  .|    .. . ..|. .
kylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnp.gfieqleqyefi

subfamily_PTPN14_pd Subfamily PTPN14 1132-1222 4.1e-06 21.0 In-house 185-283 (300) alignment
Range on Protein: 1132-1222
Range on HMM: 185-283/300.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRG--------NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|  .| |.|   |  ..... |  .||.   .||          .  ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. 
vwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtla

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 954-1115 4.2e-06 20.4 In-house 51-210 (302) alignment
Range on Protein: 954-1115
Range on HMM: 51-210/302.0
NKLLNRFANIVVYDDNRIILrpisghKDCPNGYINACYVDGYSDEYQYIATQGPVSKTV---VDFWCLVWQERPPVIVMVTNVKEEGKvKCQQYWP--DS
|   |.  .. ..|.|...|      . .|. |.||  |.  . ... | .| |.....    .|| .|.||.   .|..   .|  |   ....|    
nlkknqsedvpildsnlvkl......eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

DTKDYGPFSVTLSDEQVLTEYIiRKIHLTLLGSDQ-PPLMITQYHFTSWPDHGVPEYATSILQFHRRI
| |.|| . |     .   |    .  . .|  .    .... |..| |... ||.  ... .    .
dykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1132-1222 9.1e-06 19.4 In-house 176-266 (439) alignment
Range on Protein: 1132-1222
Range on HMM: 176-266/439.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
| ||. . |       .   .|  .  .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||...
vlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalc