Gene PTPRD-24 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP078_AA protein Get Run
AqueP078_AA_912-1230 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 909-1133 2e-110 363.2 In-house 1-226 (290) alignment 
Range on Protein: 909-1133
Range on HMM: 1-226/290.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCPNGYINACYVDGYSDEYQYIATQGPV
||||..|||||||||.||||||.|||.|||||||.||.|||||.|||||||||||||||||||.||||||||||.| ||||||..||....|||||||||
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

SKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHG-VPEYATS
|.|.|||| |.|||. ..|||.||..|||||||||||||||||.||.||..|..|..|.|||.||....   |.... ..|||..|.|...| |....|.
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

ILQFHRRIKNEYKPTKGPMLVHCSVT
.|......|...|.......|||| |
llvieemyktqrkrgntsivvHCSdt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 909-1133 4.9e-93 306.2 In-house 1-221 (287) alignment 
Range on Protein: 909-1133
Range on HMM: 1-221/287.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDS-GESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRpisghkDCPNGYINACYVDGYSDEYQYIATQGP
||||..||||||.|| ||||||||||..|.. .....  |......|| .||...|.|.|..|..|.      .. . ||||...|||......|....|
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

VSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHG-VPEYAT
...|...||.|........|||... ||. . .| ||||....  .|.....| .|.| ..||.||....  ..........||..|.|...| |.|..|
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

SILQFHRRIKNEYKPTKGPMLVHCSVT
..|......|...|.......|||| |
illvieemyktqrkrgntsivvhCsdt
subfamily_PTPRD_pd Subfamily PTPRD 909-1131 2e-77 256.1 In-house 4-222 (564) alignment 
Range on Protein: 909-1131
Range on HMM: 4-222/564.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGeSDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPV
 ||| .. |.||. . ...  |....  ...| . .| ..   | ||  ||.|||| || .|..|... |....   |||| ..|||  . .|||||||.
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPl

SKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLtLLGSDQPPLMITQYHFTSWPDHGVPEYATSI
..|. ||| .||...  .|||.|...|.|||||..|||...|. || . |||..|. |..|.||.. |    ...   ...|.||||||||||||.|||.
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatsl

LQFHRRIKNEYKPTKGPMLVHCS
|.. |....  .|..||..||||
LdlirkvralnepdagPivVhCS
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 909-1132 2.5e-69 228.8 In-house 3-225 (305) alignment 
Range on Protein: 909-1132
Range on HMM: 3-225/305.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGesDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKdcPNGYINACYVDGYSDEYQYIATQGPV
 | . .. ... . .|. ..|...|. .| .   ...  || .  ||  ||...|...||.||||.. . ..   . ||||.|||||. . .||..|||.
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPl

SKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTK--DYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYAT
 .||.||| |...|.. .|||.|...|.|| ||.||||.| |.  ..|.|||.|..|.  ..||.||....   .|.    ..||..|.|||||||..||
kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

SILQFHRRIKNEYKPTKG-PMLVHCSV
|.|.. .|.....|  || |.||||| 
sllslikrvqkdqkkdkgvpllVhCsa
0051299 (Phosphotyrosine protein) phosphatases II 908-1131 3.1e-69 229.0 In-house 3-227 (288) alignment 
Range on Protein: 908-1131
Range on HMM: 3-227/288.0
NLIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkDCPNGYINACYVDGYSDEYQYIATQGP
. |.| .. ..| . . .|. |....| .| |   |.| ...| | |.  ||. .|. ||..|..|....|  . ...|||| |.|||  . ..||||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgP

VSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLG---SDQPPLMITQYHFTSWPDHGVPEY
 ..|| ||| .||... .||||.|.. | |..|| ||||..... ||...||| .|.|| .|..|....| |.    |. ....|..|.|.|||||||..
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

ATSILQFHRRIKNEYKPTKGPMLVHCS
....|.| |.... .....||..||||
pellldflrlvrkalasgggpvvVHCs
0050432 (Phosphotyrosine protein) phosphatases II 924-1131 3.8e-65 215.6 In-house 38-240 (308) alignment 
Range on Protein: 924-1131
Range on HMM: 38-240/308.0
VKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILrpisghkDCPNGYINACYVDGY--SDEYQYIATQGPVSKTVVDFWCLVWQ
 ... ... .|. | |   ... .|.| | || .||. .|. || .|..|       | ...|||| |||||    . ..|||||| ..|| ||| .||.
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

ERPPVIVMVTNVKEEGKVKCQQYWPDS---DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
.. .||||.|.  | |..|| ||||..   ... ||.|.||| .|.|| .|..|...|| ||...  ...|..|.|.|||||||......|.| ..... 
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrks

YkpTKGPMLVHCS
.   .||..||||
l..pggpivVHCs
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 909-1131 5.3e-64 211.3 In-house 4-224 (319) alignment 
Range on Protein: 909-1131
Range on HMM: 4-224/319.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDhTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPV
 |.| .. | . . . .|. .....|..|. ...| | .   .. ||  ||. ||. ||  |..| .. | ..    |||| ..||| .. ..||||.|.
eievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegs..dyinasfidgyqerekfiatqaPl

SKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSI
..|. ||| .||.|.  ..||.|...|..|||...|||. . ..|| . ||| .|. | .|||||..|  . |.    .......|.||||.|||.|||.
entiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsl

LQFHRRIKNEYK-PTKGPMLVHCS
|.. .||..  . ...||. ||||
ldllkrirksrektqsgPivvhCs
0040438 (Phosphotyrosine protein) phosphatases II 914-1131 8.4e-64 211.2 In-house 4-217 (317) alignment 
Range on Protein: 914-1131
Range on HMM: 4-217/317.0
QFGEFVANGHVKGNEGFKNQFMMLDSGESDhTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkDCPNGYINACYVDGYSDEYQYIATQGPVSKTVV
.. ...   . ... .....|..|.|   | | .|.. | || .||. .|. ||..|..| |..|  | ...|||| ||||..   ..|||||| ..|| 
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntve

DFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHR
||| .||...  ||||.|. .| |..||.||||. .|. ||.|.||| .|..| ....|..... |  |......|..|.|.|||||||.. ...|.| .
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfle

RIKNEYKPTKGPMLVHCS
.... ... .||.|||||
avrealedpggpvlVHCs
0036941 (Phosphotyrosine protein) phosphatases II 925-1131 5.2e-63 208.5 In-house 10-215 (297) alignment 
Range on Protein: 925-1131
Range on HMM: 10-215/297.0
KGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILrpisghKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERP
... ... .|. |..   . . .|.| | |. .||. .|. ||..|..|      .| ...||||.|||||. ....|||||| ..|| ||| .||... 
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

PVIVMVTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTLSDEQV--LTEYIIRKIHLTLLGSDqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK
.||||.|.. | |..||.||||.   ... ||.|.||| ...|  |..|..|....| .|.. .....|..|.|.||||||||...|.|.| ..... .|
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlk

--PTKGPMLVHCS
  | .||.|||||
llpsggpvlVHCs
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 910-1131 5.4e-63 208.0 In-house 2-221 (318) alignment 
Range on Protein: 910-1131
Range on HMM: 2-221/318.0
IPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVS
|.| .. . |.. . .|.  ..... .|.  |.  |..  |.| ||  ||.|||. ||. |. |....|...    |||| |.|||  . .|||.|.|..
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeeg..sDyinanyidGyrrkkayiaaqaPlp

KTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSIL
.|. ||| .||.    ||||.|...|.||.|...|||..... ||   |.|..|  |..|..|....|  ....   .. |||.|||||.|||| ..|.|
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeee.srqvrqyhytsWpdegvpesgasll

QFHRRIKNEY-KPTKGPMLVHCS
.. |....   |...||..||||
dlvrqvskaqqksgagpivvhCs
0046845 (Phosphotyrosine protein) phosphatases II 930-1131 5.5e-62 205.0 In-house 2-212 (284) alignment 
Range on Protein: 930-1131
Range on HMM: 2-212/284.0
FKNQFMMLDSGESDH--TATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHkDCPNGYINACYVDGY-----SDEYQYIATQGPVSKTVVDFWCLVWQE
.. .|..| |   ..  . .|.| | |. .||. .|..||..|..|....|. .  ..|||| |||||       . ..||||||...|| ||| .||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RPPVIVMVTNVKEEGKVKCQQYWPDSD-TKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-
. .||||.|.  | |..|| ||||... .. ||.|.||| .|.|   |..|.. || || .......|..|.|||||||||......|.| | ... .. 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-PTKGPMLVHCS
 |..||..||||
lpgggpivVHCs
0047943 (Phosphotyrosine protein) phosphatases II 924-1131 2.3e-61 203.0 In-house 8-213 (273) alignment 
Range on Protein: 924-1131
Range on HMM: 8-213/273.0
VKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILrpisghKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQER
 .|. ... .| .| |   ..| .|.| | || .||. .|. ||..|..|      .| ...|||| |||||  . ..|||||| ..|| ||| .||...
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

PPVIVMVTNVKEEGKVKCQQYWPDSD---TKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK
 .||||.|.. | |..|| ||||..    .. ||.|.||| .|..   |..|.. || ||... ....|..|.|.|||||||.. .|.|.| . ... ..
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkale

P--TKGPMLVHCS
    .||..||||
alpsngpvvVHCs
subfamily_PTPRB_pd Subfamily PTPRB 908-1131 8.1e-61 200.6 In-house 5-226 (293) alignment 
Range on Protein: 908-1131
Range on HMM: 5-226/293.0
NLIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGP
. | . .| |.|.. . . . .|.... .| . ..|.. ..  .. |.  ||. ||. || .|. | .......  . |||| |..||. . ..||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesg..sDYinanyipgynsprefiatqGP

VSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDS-DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLlgsDQPPLMITQYHFTSWPDHGVPEYAT
. .|| ||| .||...  .|||.|.. |.|||||..|||.  ..  ||  .|||  |..|....||.....    ..    ..|||||||||||||| ..
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektk

SILQFHRRIKNEY--KPTKGPMLVHCS
..|.| |.....   . .|.|..||||
tlldfvrtvreaiektaskrPivvhCs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 926-1133 4.3e-60 197.9 In-house 13-236 (301) alignment 
Range on Protein: 926-1133
Range on HMM: 13-236/301.0
GNEGFKNQFMMLDSGEsDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPP
 ...|..|.  |..|| |...||||. .|| |||| ||.|||||||||.| .  . | . |||| |.||||.. ..||.|||. ||.||||.|.|||.| 
hsnkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

VIVMVTNVKEEGKVKCQQYWPDSD--TKDYGPFSVTLSDEQVLTEYIIRKIHLTLL--------------GSDQPPLMITQYHFTSWPDHGV-PEYATSI
 |||||| ||. | ||.||||.|.  ....|||.|||..|||. ...||.. ...                ||. .  ..|.. |.||..|| .|..| .
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

LQFHRRIKNEYKPTKGPMLVHCSVT
   .  |. . |. .||..|||| |
qviddvihrqqkigggpvvVHCSdt
subfamily_PTPRG_pd Subfamily PTPRG 910-1131 5.3e-60 198.2 In-house 1-228 (563) alignment 
Range on Protein: 910-1131
Range on HMM: 1-228/563.0
IPVGQFGEFVANGHVKGNEGFKNQFMML--DSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCPnGYINACYVDGYSDEYQYIATQGP
.|| .| . ||. | .|. ||...|  |   . ..| .|.    |.||  ||  ||| ||  |. |.|..|.|.    |||| |.|||  . ..||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

VSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTL---LGSD--QPPLMITQYHFTSWPDHGVP
. .|. ||| ..|...  .|||.||..|.|. ||..|||  ....|| ..||| .|.||. | .|.. .        .  .  ....|||.|.|||||||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

EYATSILQFHRRIKNEYKPTKGPMLVHCS
|...  |.| .. .   | . ||..||||
ehslpvLifvkkssaankaeaGPivvHcs
0045450 (Phosphotyrosine protein) phosphatases II 909-1131 1.8e-59 197.3 In-house 8-242 (307) alignment 
Range on Protein: 909-1131
Range on HMM: 8-242/307.0
LIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGES--DHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHkDCPNGYINACYV--------DGYSDE
.|.. ..  .|.  . ....|.. .| .| | .    .. ...| | || .||. .|. ||..|..| ...|. . ...|||| ||        |||   
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlk

YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSD-TKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWP
 ..|||||| ..|| ||| ..|...  ||||.|. .| |..|| |||||.. .. ||.| ||| .|..| .|..|....| |. .......|..|.|.||
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp

DHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCS
|||||..  ..|.| ..... .   | .||.|||||
dhgvppsfeelldfieevrkaleelpkggpvlVHCs
0043336 (Phosphotyrosine protein) phosphatases II 911-1131 1.9e-59 196.7 In-house 3-218 (278) alignment 
Range on Protein: 911-1131
Range on HMM: 3-218/278.0
PVGQFGEFVANGHVKGNEGFKNQFMMLDSGESdHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSK
.| .. ..... . ... .....|  |.|     | ...| | || .||. .|. || .|..| ...|. |  ..|||| |||||.   ..|||||| ..
svkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpe

TVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPdSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQ
|| ||| .||... ..|||.|. .| |.|||.|||| .... ||.|.||| .|..|  |..|....| ||.... ...|.||...||||||||  ...|.
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllld

FHRRIKNEYKPTKGPMLVHCS
| ..... ... .||.|||||
flkavrealedsngpvlVHCs
0039614 (Phosphotyrosine protein) phosphatases II 912-1131 3.1e-58 192.9 In-house 16-230 (297) alignment 
Range on Protein: 912-1131
Range on HMM: 16-230/297.0
VGQFGEFVANGHVKGNEGFKNQFMMLDSGESDhtATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHkDCPNGYINACYVDGYSD-EYQYIATQGPVSK
.. .  ..   . ... .....|..| |   |   ...| | || .||. .|. ||..|..| |. |. | .. |||| |||||.    ..|||||| ..
lsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpe

TVVDFWCLVWQERPPVIVMVTNVKEEGKvKCQQYWPDSDTkDYGPFSVTLSDEQVLTEYIIRKIHLTLlgsDQPPLMITQYHFTSWPDHGVPEYATSILQ
|| ||| .||... .||||.|. .| |. ||.||||.. .  ||.|.||| ....|  |..|....|    .......|....|.|||||||......|.
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellle

FHRRIKNEYK--PTKGPMLVHCS
| . ... ..  | .||.|||||
flelvrealaelpkggpvlVHCs
DSPc_SM00195 930-1131 6.6e-58 191.5 In-house 2-203 (263) alignment 
Range on Protein: 930-1131
Range on HMM: 2-203/263.0
FKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHkdCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVM
.|..|  |.. .|... | .  ..||  ||. ||..||..|..| .. ..   .. |||| |..|.. . .||||||| ..|| ||| .||.|. ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTLSDEQVLT-EYIIRKIHLTLLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
.|. .|.|| ||..|||..  .....| .||.| ...    |.|.|...||  |  . .  .|||....|||||||. ..|.|.. | .|.... ..||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCS
.||||
vVhCs
PTPc_SM00194 930-1131 6.6e-58 191.5 In-house 2-203 (263) alignment 
Range on Protein: 930-1131
Range on HMM: 2-203/263.0
FKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHkdCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVM
.|..|  |.. .|... | .  ..||  ||. ||..||..|..| .. ..   .. |||| |..|.. . .||||||| ..|| ||| .||.|. ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTLSDEQVLT-EYIIRKIHLTLLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
.|. .|.|| ||..|||..  .....| .||.| ...    |.|.|...||  |  . .  .|||....|||||||. ..|.|.. | .|.... ..||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCS
.||||
vVhCs
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 920-1131 2.6e-57 189.3 In-house 19-231 (298) alignment 
Range on Protein: 920-1131
Range on HMM: 19-231/298.0
ANGHVKGNEGFKNQFMMLDSGES---DHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPVSKTVVDFW
|  . |.  |....|  |.|..|   ... .|. .|.||  ||.|.|. .|  |..|. ... ...   |||| ....|...  .||||.|. .||.|||
avkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadees..dYiNAsflhaykgrnafiatqaPltetvedFW

CLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK
 .|..|   .|||.||..| .|.|...||||. .. || ..|.|  ... ...|.||....   ..    .. | |||||||.||||.|||.|.. |...
rmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvr

NeYKPTKG--PMLVHCS
  ..   |  |..|.||
a.sqqqagnkpvivqCs
subfamily_Ptp69D_pd Subfamily Ptp69D 916-1132 2.7e-57 189.2 In-house 10-228 (307) alignment 
Range on Protein: 916-1132
Range on HMM: 10-228/307.0
GEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPVSKTVVDF
 | . . . . ..|... . .| . |.|....|.    |.| ||. .|. .|..|..|..| |..|    |||| .. || .. ..|| |.||  |. ||
eealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkeds..dYinasfikgykekkkfiaaqdPveatigDf

WCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQ----PPLMITQYHFTSWPDHGVPEYATSILQF
| ....    .|||..|..|  . ||..|||. |.. ||   |.| .|.  ..||||.....  . .         ..|||.|.|.|  ||| |...|..
WRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkl

HRRIKNEYKPTKGPMLVHCSV
 ..... ||  ..|..|||| 
ieqvrelyklnrsPivvhCsa
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 918-1131 3.8e-57 188.6 In-house 11-220 (288) alignment 
Range on Protein: 918-1131
Range on HMM: 11-220/288.0
FVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWC
 ||. . ....||....  | . |.... |.|  . |.  ||. ||. || .|. |.     ..  . |||| |.||.  . .|||||||. .|| ||| 
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeag..aDYinasyidgekkkkkyiatqgPladtvndfWe

LVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDT-KDYGPFSVTLSDEQVLTEYIIRKIHLTllgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK
||....   |||.|.. |.|| ||..||||.|. | || . ||| ... |.... ||. |     ..  | ||||....|||||||| .. .|.. | .|
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvk

NEYKPTKGPMLVHCS
.  .   ||..||||
vanqadtgpiivhCs
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 925-1131 2.2e-56 186.0 In-house 12-216 (281) alignment 
Range on Protein: 925-1131
Range on HMM: 12-216/281.0
KGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERP
. |.||....  | . . |.|||   .. |.| ||. ||| ||  |. . | . .|..   |||| .|.||..| .|||||||| ...|.|| .||... 
ndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenknt..DYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkv

PVIVMVTNVKEEGKVKCQQYWPDSD-TKDYGPFSVTLSDEQVLTEYIIRKIHLtlLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK-NEYKPT
 .|||||.  |.||.|| .|||| . .  || . |.   |.  ..|| ||..|    .. ..  ..| ..|.|||||||. .. .|.|.. ..  . | |
saivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekkt

KGPMLVHCS
| |...|||
kaplvihCs
subfamily_PTPRA_pd Subfamily PTPRA 908-1132 4.6e-56 185.1 In-house 12-237 (330) alignment 
Range on Protein: 908-1132
Range on HMM: 12-237/330.0
NLIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGP
  .|| .. | .       |. |...|  | .|. . |  .     ||  ||. ||. || .|.|| ...|...    |||| ..||| .  ..||.|||
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvees..dyinasfidGykekdkfiaaqGP

VSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSD---QPPLMITQYHFTSWPDHGVPEY
 ..|| ||| ..|. .   |||.|..||  . ||.|||||  .  ||   |.. ||.|| .| .||. .. |.     ... ...|.||||||| |||  
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

ATSILQFHRRIKNEYKPTKGPMLVHCSV
.  .|.. ...|.  . . ||. |||| 
piGmlkllkkvkklnqqsagpivvhcsa
subfamily_PTPN6_pd Subfamily PTPN6 921-1131 1e-55 183.9 In-house 19-235 (306) alignment 
Range on Protein: 921-1131
Range on HMM: 19-235/306.0
NGHVKGNEGFKNQFMMLDSGESDH--TATVGLTPSNKLLNRFANIVVYDDNRIILRpisGHKDCPNGYINACYVDGY--SDEYQYIATQGPVSKTVVDFW
... ....||...|  |.  |. .  . . |  |.||  ||. ||. .|..|.||.    ..   . |||| |...   . . .|||||| ...|| |||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

CLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSD-TKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRI
 .||||   ||||.|.  | || || .||||.  ...||  |||  .|. |..||.|.....   ...    . ||||.||||||||.    .|.| . .
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledv

KNEYKPTK----GPMLVHCS
..... ..    ||..||||
nrkqeeleeaeagpivvhCs
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1131-1226 2.1e-54 179.4 In-house 179-274 (290) alignment 
Range on Protein: 1131-1226
Range on HMM: 179-274/290.0
SVTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQL
||||.|.|||||||.|.||||||...||||.||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||...|.
svtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqg
subfamily_PTPRK_pd Subfamily PTPRK 928-1131 2.3e-54 179.4 In-house 22-218 (314) alignment 
Range on Protein: 928-1131
Range on HMM: 22-218/314.0
EGFKNQFMMLDSGesdhtATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVI
 |||...  |  |       .     |.  ||. .|. ||  |..| .| |  |  . |||| ..|.|    ..|.||||. .|| ||| ||..|.   |
ygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasi

VMVTNVKEEGKVKCQQYWPDSDTKdYGPFSVTLSDEQVLTEYIIRKIHLTLL-GSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
||.|...|.|.||| .|||.  .. ||.. |.| . ..|.|...|   .. |  . .   .. |..|..||||.|| .||..|.. ||.|.  ....|..
vmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGri

LVHCS
.||||
vvhCs
0045098 (Phosphotyrosine protein) phosphatases II 943-1131 2.7e-54 179.8 In-house 22-214 (278) alignment 
Range on Protein: 943-1131
Range on HMM: 22-214/278.0
DHTATVGLTPSNKLLNRFANIVVYDDNRIIlrpisghkdcpnGYINACYVDGYsdEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQ
  . |..| ..|. .||. .|. || .|..            .|||| |.|||    ..||||||  .|| ||| ..|... .||||.|...| |..|| 
pseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

QYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLL---GSDQPPLMITQYHFTSWPDHGVPEYA--TSILQFHRRIKNEYK-------------PTKG
||||..... ||.|.||| .|.|| .|..|....| |    .| ... .|..|...|||||||..   .|.|.. ..|.. .|             . .|
qywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PMLVHCS
|.|||||
pvlVHCs
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 948-1131 2.7e-53 175.7 In-house 3-183 (250) alignment 
Range on Protein: 948-1131
Range on HMM: 3-183/250.0
VGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpnGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVkCQQYWPD
|.  |.||  ||.|.|. .|  |..| . .| |..   |||| ...||...  .||||||...|..||| .|..|   .|||.||.||..|. ..|||| 
vakkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

SDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCS
  .. ||   |.| .... ..|..||. |.   . .   .. |.||..||| ||||.||..|.. .... . .   ..|..|.||
ekaekyGdvtvsllskeefadytkrklklska.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCs
Y_phosphatase Protein-tyrosine phosphatase 954-1131 4.3e-53 175.5 Pfam-A 1-178 (235) alignment 
Range on Protein: 954-1131
Range on HMM: 1-178/235.0
NKLLNRFANIVVYDDNRIILrpisG----HKDcpngYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWP--D
||  ||. .|..||..|. |         ..|    |||| ||.||... ..||||||...|. ||| .||||.  ||||.|...|.|..||.||||  .
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee

SDTKDYGPFSVTLS-DEQ-VLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCS
.... || ..|.|  .|.   .||..||..|.  .... . ...|.|.|.|||||||| ..|.|.. |..... ....||..||||
eesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs
Y_phosphatase Protein-tyrosine phosphatase 954-1131 4.3e-53 175.5 In-house 1-178 (235) alignment 
Range on Protein: 954-1131
Range on HMM: 1-178/235.0
NKLLNRFANIVVYDDNRIILrpisG----HKDcpngYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWP--D
||  ||. .|..||..|. |         ..|    |||| ||.||... ..||||||...|. ||| .||||.  ||||.|...|.|..||.||||  .
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee

SDTKDYGPFSVTLS-DEQ-VLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCS
.... || ..|.|  .|.   .||..||..|.  .... . ...|.|.|.|||||||| ..|.|.. |..... ....||..||||
eesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs
0040439 (Phosphotyrosine protein) phosphatases II 946-1131 4.4e-53 175.8 In-house 3-187 (249) alignment 
Range on Protein: 946-1131
Range on HMM: 3-187/249.0
ATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYW
 .|.| | || .||. .|. || .|..| ...|    ...|||| |.|||    ..|||||| ..|| ||| ..|...  ||||.|. .| |..||.|||
ysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCS
|..... || |.||| ...|. .|..|...|| |  |...........|.|||||||..  ..|.| ..... ..  |..||.|||||
plggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCs
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1132-1222 1.7e-52 173.2 In-house 175-265 (287) alignment 
Range on Protein: 1132-1222
Range on HMM: 175-265/287.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|.|.|.|||||||.|..|||||...||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 
vkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtve
0042113 (Phosphotyrosine protein) phosphatases II 948-1131 1.5e-51 170.5 In-house 3-184 (245) alignment 
Range on Protein: 948-1131
Range on HMM: 3-184/245.0
VGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCPngYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPD
|.| | || .||. .|. ||..|..| |..|. |..  ||||.|||||    ..|||||| ..|| ||| ..|...  .|||.|.  | |.|||.||||.
vallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

SDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCS
.... || |.||| .|..| .|..|....| |  | .......||...|||||||..  ..|.|...... .. . .||.|||||
gesltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCs
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 907-1131 4.3e-51 168.7 In-house 3-220 (315) alignment 
Range on Protein: 907-1131
Range on HMM: 3-220/315.0
KNLIPVGQFGEFVANGHVKGNEGFKNQFMMLDSGEsDHTATVGLTPSNKLLNRFANIVVYDDNRIILrPISGhKDCPNGYINACYVDGYSDEYQYIATQG
.. ||. |.  .||. .   ..|||...  .  |.  |   |     ||  ||. ||. ||  |. | |.   .|    |.|| ..|||. . .|||.||
hqpipldqlityvaqkkastkngfkqdyesipggq.lhpldvakkienkqknryiniiaydksrvql.plle.ndphsdyvnanfidGynkkrryiaaqg

PVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSdTKDYGPFSVTLSDEQVLTEYIIRKIHLTlLGSDqpPLMITQYHFTSWPDHGVPEYAT
|   .| ||| ||..|    |||.||. |. | |...||||     ||...||. .|.| ||| .| .  .  |..     . |.|.||||| |||.|..
pnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvv.fgdn..irevvqlhytswpdmgvpkyti

SILQFHRRIKNEYKPTKGPMLVHCS
......|..|   . . |...||||
plmnlirtvkqhhtnsvgaivvhcs
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 910-1131 6.6e-51 168.0 In-house 3-218 (315) alignment 
Range on Protein: 910-1131
Range on HMM: 3-218/315.0
IPVGQFGEFVANGhvKGNEGFKNQFMMLDSGESdHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVS
||| ||  || .   .    | ..|  |   .  .  .|. .. |   ||. ||. .| .|..|  |  . |  . |||| |. .. |.  |||.|||  
ipvaqfpafvnkn..rhtalfseefhdlpdPdi.yrqrvaretinfkknryknilPldsarvkleviddsPd..sdyinasyiksvdddkayiasqgPlk

KTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPD--SDTKDYGPFSVTLSDEQVLTEYIIRKIhLTLLGSDQppLMITQYHFTSWPDHGVPEYATS
 .| ||| .|.||..  |||||. .|. |.||.|||||  .|. ..| ..|.| . .  |. ..||.  |  . ..    .||..|| |||.||.. ..|
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrksees..rtvtqfqftewPdkGvdkqtss

ILQFHRRIKNEYKPTKGPMLVHCS
.|.. . .| . .. . ..|||||
llklikevkadngkkefsllvhcs
subfamily_PTPN12_pd Subfamily PTPN12 942-1131 3.1e-49 162.4 In-house 28-215 (290) alignment 
Range on Protein: 942-1131
Range on HMM: 28-215/290.0
SDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKdcPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKC
. .....| ...|.  ||. .|. || .|. |. |....   ..|||| .. | ... .|||.|||..||. ||| ..|. .  ..||. .. | || ||
kvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

QQYWPDSDTK--DYGPFSVTLSDEQVLT-EYIIRKIHLTLLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCS
..|||..  .   .|.|.|||..|. .. ...|| ....  .  .   ...|.|.|.|||||||. |.|.|.. . ...  .  . |..||||
erYWpeegeeelefgefevtleeekavdddflirtLkveaqkesr...kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCs
0037934 (Phosphotyrosine protein) phosphatases II 948-1131 3.9e-49 162.8 In-house 4-186 (243) alignment 
Range on Protein: 948-1131
Range on HMM: 4-186/243.0
VGLTPSNKLLNRFANIVVYDDNRIILrpisghKDcpNGYINACYVDGYSdeyQYIATQGPVSKTVVD----FWCLVWQERPPVIVMVTNVKEEGKVKCQQ
..| | |.  ||. .|. ||..|..|      ..  ..|||| .....    ..|||||| ..|| |    || ..|...  ||||.|. .| |..|| |
iallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPdsDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--------YKPTKGPMLVHCS
|||  ... ||.|.||| .|..| .|..|...|. |. |........||...|||||||.  ...|.|.. ...         . ...||.|||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 953-1132 5.3e-48 158.3 In-house 2-181 (237) alignment 
Range on Protein: 953-1132
Range on HMM: 2-181/237.0
SNKLLNRFANIVVYDDNRIILRPISGHkdcpNGYINACYVDGYSD-EYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDT-
 ||. ||..|||.|| .|..|.   .       ||||.|..|.     .|||.|||.  .  ||| .||||.  ||||.| . |  ..|| .|||..|  
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

KDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSV
. || ..|.|  .. ...| .| . |.  .. .   .| ||.||||||.|||......|.| ..| |. .  .  || ..||| 
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsa
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 954-1132 9.8e-48 157.4 In-house 8-183 (239) alignment 
Range on Protein: 954-1132
Range on HMM: 8-183/239.0
NKLLNRFANIVVYDDNRIILRPISghKDCPNGYINACYVDGYSDE-YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKd
||  ||.|||| || .|..|  .|  .|  . |||| |.  |      |||||| |. .  ||| ..||||  ||||.| . |  | ||.|||||| .| 
nkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSV
|  . |||   .|...|||| . .. .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||| 
ycnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsa
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 954-1132 1e-47 157.3 In-house 7-182 (239) alignment 
Range on Protein: 954-1132
Range on HMM: 7-182/239.0
NKLLNRFANIVVYDDNRIILRPISghKDCPNGYINACYVDGYSDE-YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKd
||  ||.|||| || .|..|  .|  .|  . |||| |.  |      |||||| |. .  ||| ..||||  ||||.| . |  | ||.|||||| .| 
nkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSV
|  . |||   .|...|||| . .. .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||| 
ycnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsa
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 923-1132 1.9e-47 156.5 In-house 4-208 (283) alignment 
Range on Protein: 923-1132
Range on HMM: 4-208/283.0
HVKGNEGFKNQFMMLDSgeSDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkdcpnGYINACYVD---GYSDEYQYIATQGPVSKTVVDFWCLV
.|..|. |....  |     |  |..  .  ||  ||. .||..| .|. |.. |        ||||...     | .. .||..|.|. .|||||| .|
rvnnnklfrevlkrlsv..pdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmv

WQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
..|.   |||.|...|. ..|| ||||   ..|||.| ||| .|     .||... |   .| .  |... | .  | . |      |...| . | .  
fdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqt

KPTKGPMLVHCSV
.  |||..|||| 
eskkgPivvhCst
subfamily_PTPN9_pd Subfamily PTPN9 917-1118 4.1e-47 155.6 In-house 5-205 (297) alignment 
Range on Protein: 917-1118
Range on HMM: 5-205/297.0
EFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFW
|.||  . ||..| ..... . . .   |...  ...|   ||..... ||. |. |  .....     |||| .||||  .  .||||||. ||| |||
elvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedea..sdyinanfvdGykqkkafiatqGplkktvsdfW

CLVWQERPPVIVMVTNVKEEGKVKCQQYWP--DSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRR
 .||...  ||||.| | |.|..||.||||  . .....| .||.  . ..  .| .|.....    ..    .| . |.||||.|||. |.|.|.. . 
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktees.rkvthfqflsWPdyGvPssaaslldvlek

IKNE
....
vrek
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 910-1131 5e-47 155.2 In-house 2-217 (515) alignment 
Range on Protein: 910-1131
Range on HMM: 2-217/515.0
IPVGQFGEFVANGHVkgNEGFKNQFMMLdSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVS
.|. ||  ||.         | ..|  |  |   .  ||     |   ||. ||. || .|..|  |    .  . |.|| |. ..  .  |||.|||  
lplaqfPafvnknrh..ttlfseefhdl.pgpniypqtvaqeeinfkknryknilPydsvrvklevindnPh..sdyfnasyipsfdndkayiasqgPnk

KTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPD--SDTKDYGPFSVTLSDEQVLTEYIIRKIHLtlLGSDQpPLMITQYHFTSWPDHGVPEYATS
 .| ||| ||.||..  |.|||. ||. |.|| .||||  .|.  .| ..| |   .  |. |.||...  | .|.    .||.||| |||.|||. ..|
asvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgdd.srtvtqfhfteWPdkGvpkhtss

ILQFHRRIKNEYKPTKGPMLVHCS
.|.. . .| .    . |...|||
llklikevkadhgqythpliihcs
subfamily_PTPN3_pd Subfamily PTPN3 933-1131 5.8e-46 151.6 In-house 20-216 (280) alignment 
Range on Protein: 933-1131
Range on HMM: 20-216/280.0
QFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRpisghkDCPNGYINACYVDG----YSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIV
|| .|   . . . ..   | |   ||. .|. ||. |..|.      . .. |||| ||.      .   .|||||||..||. ||| .||...  .||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MVTNVKEEGKVKCQQYWPDS-DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPML
|.|.. |.|.||| ||||.. |. .|| |||... |.  ..|..|.. |.   ...   .|.|  ...|||||||. ....|.| .|...  . .. |..
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketke.erkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvv

VHCS
||||
vhCs
subfamily_PTPN23_pd Subfamily PTPN23 923-1131 4.9e-44 145.3 In-house 10-220 (288) alignment 
Range on Protein: 923-1131
Range on HMM: 10-220/288.0
HVKGNEGFKNQFMMLDSGESDHTAT--VGLTPSNKLLNRFANIVVYDDNRIILRpisGHKDcpnGYINACYVDGYSDE-YQYIATQGPVSKTVVDFWCLV
 ..|. .....|  |.. .  ..    . .   .   ||. .|. || ||. ||   |.||    ||||..| . |    ..||||.|  .|. ||| .|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskD...DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WQERPPVIVMVTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKN
.... .||||... .| || |...||| .  .|. .|..||||.... . ... |...|. |..|.   ...  ..||||..|||.   ..|||   ...
yeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadav.ksvshlqltsWpelGvPasPetllqfldeves

E----YKPTKGPMLVHCS
      ...| |..||||
ayeavqrksktPlvvhCs
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 947-1132 1.4e-43 144.4 In-house 54-233 (319) alignment 
Range on Protein: 947-1132
Range on HMM: 54-233/319.0
TVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTnvkeegKVKCQQYWP
|    . ||  ||. ||. .| |.. |... |       |||| .|.||  . .|||.|||   |. ||| ..|. .   ||..|      | || ||||
tfanldqnkdknriinilafdknvvklerliGeef..sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

DSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSV
    . .. | | ..  .   ||..|.|.|.  |  .    |||.||  |||.|||.|.. .... ....     .  . ...|||| 
lkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsa
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 947-1132 3.7e-43 143.1 In-house 18-197 (284) alignment 
Range on Protein: 947-1132
Range on HMM: 18-197/284.0
TVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTnvkeegKVKCQQYWP
|    . ||  ||. .|. .| |.. |... |       |||| .. ||  . .|||||||   |. ||| ..|. .   ||..|      | || ||||
tfanldqnkdknrighilafdknvvklerliGeef..sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

DSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSV
    . .. | | ..  .   ||..|.|.|.  |  .    |.|.||  |||.|||.|.. .... ....     .  . ...|||| 
lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 952-1132 7.7e-43 141.5 In-house 26-210 (274) alignment 
Range on Protein: 952-1132
Range on HMM: 26-210/274.0
PSNKLLNRFANIVVYDDNRIILRPISGHKDCpNGYINACYVDGYSDEY-QYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDT
. ..  ||. .|.  .  |..|.. |....    |||| |. ||. |   |.|||||...|| ||| ...||. .||||.|..||. . ||..|.||.  
fgsqtknryktilPnensrvllesesseded.ssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaed

K----DYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPplmITQYHFTSWPDHGVPEYATSILQFHRRIKNE---YKPTKGPMLVHCSV
      || .... ..     .| .||. |  | . .    .. | .|.|||| .|. |...|.. . ....    .   .|..|||| 
yeiserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsa
subfamily_PTPN13_pd Subfamily PTPN13 941-1132 1.1e-42 141.2 In-house 24-211 (273) alignment 
Range on Protein: 941-1132
Range on HMM: 24-211/273.0
ESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkdcpngYINACYVDG--YSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGK
 .  |..|| . .||  ||. |.. ||. |..|   .|       |||| ..      |||.|||.|||. .|| ||| .||. .  ||.|||. ||.||
kpldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk

VKCQQYWPDSDTKD---YGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSV
|||..|||.|  |    .. . |.| . | | .. .|..... . | .    ... .|..|||||||  |...||| .....  .  .||..|||| 
vkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsa
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 907-1131 4.6e-41 135.9 In-house 7-225 (297) alignment 
Range on Protein: 907-1131
Range on HMM: 7-225/297.0
KNLIPVGQFGEFVANGHVkgNEGFKNQFMMLdSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISghKDCPNGYINACYVDGYSDeyQYIATQG
.. ||. .|  .| ...    . |...|  |      ...||     |   .|..||. || .|..|. .   .|    |.|| .| |.    ..|.|| 
rrpiplsdfatlvqknrh..tdvfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqm

PVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKvKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLlGSDQPPLMITQYHFTSWPDHGVPE--Y
|   || ||| .|..|.. .|||... .|. | ||..||.|. .. .|  ||.|.  .  . .| |....|  |. .   .. ||.|..|||. |..   
PmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkds

ATSILQFHRRIKNEYKPTKG-PMLVHCS
|.|.|..   ...... ..  |.||||.
assllklisevrkdfsqnaegPllvhcl
subfamily_PTPRN_pd Subfamily PTPRN 923-1131 1.8e-40 133.5 In-house 24-232 (297) alignment 
Range on Protein: 923-1131
Range on HMM: 24-232/297.0
HVKGNEGFKNQFMMLDSGESDH-TATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYV-DGYSDEYQYIATQGPVSKTVVDFWCLVW
|.| .. .....  | . |..  |..|. .. |   || .... ||..|. |.  . ...  . ||||  . |    .  |||||||...|| ||| .||
hlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaek..sdyinasaildhdprapayiatqgplastvadfwqmvw

QERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLT-EYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
..   |||..|...|||  .|..||||  .. |. . | |  | . . .|..| ..|  | ...    .||.|| |||..|||  | |.|.| |..   |
eqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPasaksllefrrkvnksy

KPTKGPMLVHCS
.    |..||||
rGrscpivvhcs
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 912-1131 8.9e-40 131.8 In-house 7-229 (325) alignment 
Range on Protein: 912-1131
Range on HMM: 7-229/325.0
VGQFGEFVANGHVKGNEGFKNQFMMLDSGESdHTATVGLTPSNKLLNRFANIVVYDDNRIILRPIsgHKDCPNGYINACYVDGYSDEYQYIATQGPVSKT
| .. |.| . . . ..|| ..| .| | ..  . .|   | ||  ||| |.| .| .|..|     ..|    |||| |.  . .   ..|.| | ..|
vvnlvehvekkkaqdqdgfahefgllpsddg.iakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltat

VVDFWCLV--WQerPPVIvMVTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYATS
. |.| ||  |.   .|. .|.|. ..|| .| .|||.   ..| .|.. | |   . ...|. |....    ..   . . |... ||.| ||... ..
indlWrlvldWr..csvv.vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqv.kkGetrsvkqfqlqswddmGvqkrpat

ILQFHRRIKNEY---KP---TKGPMLVHCS
.. . . .|.     .    . .|.|||||
lisilqlvkavservtantkastpilvhcs
subfamily_PTPN1_pd Subfamily PTPN1 930-1132 1.2e-39 130.7 In-house 8-210 (290) alignment 
Range on Protein: 930-1132
Range on HMM: 8-210/290.0
FKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRpisghkDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVM
.|. .. ..   ||.....  .|.|. |||. ..  ||  ||.|.      .  | ||||  |.    . .|| ||||...||  || .||...   .||
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle......radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

VTNVKEEGKVKCQQYWPDSDT-----KDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPT
. .| |....||.||||  .       .   ..|.|  |..  .|..|...|. | ...    |...|.|.||| ||||  .. |.|  ....    .. 
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqet.reilhfhyttwpdfgvpespaaflkflfkvresGslssd

KGPMLVHCSV
.|| ..||| 
vGpavihcsa
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 937-1131 8.8e-38 124.8 In-house 4-205 (270) alignment 
Range on Protein: 937-1131
Range on HMM: 4-205/270.0
LDSGESDHTaTVGLTPSNKLLNRFANIVVYDDNRIILRPISGhkDCPNGYINACYVDGYSDE-YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKE
|| .|.... ..  .  .| |||.|.|.     |..| ...   |    |||| || |...|  .|||..||.  |. .|| ..|.|. . |||.|...|
ldkeetses.dlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

EGKVKCQQYWPDSDTK----DYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpPLMitQYHFTSWPDHGVPEYAT------SILQFHRRIKNEYKPT-KG
.|. ||..||| .  .     .|  .|. . |.  . ||.....|.  |. .  |.   .....|||||||. .       ..|.  | ...  | . |.
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeer.rlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka

-PMLVHCS
 |.|||||
ePllvHcs
subfamily_PTPN14_pd Subfamily PTPN14 943-1131 6e-37 122.2 In-house 38-237 (300) alignment 
Range on Protein: 943-1131
Range on HMM: 38-237/300.0
DHTATVGLTPSNKLLNRFANIVVYDDNRIILRPisgHKDCPNGYINACYVDG--YSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVK
| . ...  | |.  ||| ... |.|||. | |    |.  .|||||  .     . |..||..|||. .|| ||| .||..   .|||.|. .|.|| |
dallstaklpenaeknrfkdvlPyednrvelsp...tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

CQQYWPDS----DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQP-PLMITQYhfTSWPDHGVPEYATSILQFHRRIK------NEY---KPTKGPM
. .|.|..    .| ..| | ||    .  . .| ....|  | | .   ... ||  | ||||||||  .. |.. ....      |.    | .| |.
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

LVHCS
|||||
lvhCs
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 957-1133 2.1e-35 116.9 In-house 41-220 (287) alignment 
Range on Protein: 957-1133
Range on HMM: 41-220/287.0
LNRFANIVVYDDNRIILrpiSGHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDT-KDYGP
 ||.|... .||.|..|   | . .    |||| || .| |. ..||.|||.. || |||..|...|  .....|   ||.. || .|||. .     | 
knryadvlPiddtrvll...saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGG

FSVTLSDEQVL-TEYIIRKIHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-----KPTKGPMLVHCSVT
.||.| | ...  || .| . |  | . .   .. |... ||||....  | ....|   .|.           ||..||..| 
ysvvlldydikePeygvralrlidletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG
subfamily_CG7180_pd Subfamily CG7180 949-1131 2.8e-35 116.4 In-house 37-231 (296) alignment 
Range on Protein: 949-1131
Range on HMM: 37-231/296.0
GLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCPngYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKvKCQQYWPDS
||   |.  ||  ..| || ||..|. . |...    |||| |||..  . .|| |..|. .|| .|| ||..|    .|..|.. .  | ....|||  
glrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLL---------GSDQPPLMITQYHFTSWPD-HGVPEYATSILQFHRRIKN-----EYKPTKGPMLVHCS
  ..||.. | .  |. ...  ||...||           . . .  .......| |.  . ||  ....... ||..      . .|..||..|..|
skeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvss
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 909-1132 1e-34 114.6 In-house 3-178 (392) alignment 
Range on Protein: 909-1132
Range on HMM: 3-178/392.0
LIPVGQFGEFVANGHVkgNEGFKNQFMMLDSGESdHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPV
 ||| ||  || . .   .  | ..|  | . .  .  ||. .. |.  ||. ||. || .|..|  |    |  . |.|| |....  |  |||.||| 
pipvaqfpafveknrh..salffeefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddipd..sdylnasyipsfdnekayiasqgpn

SKTVVDFWCLVWQERPPVIVMVTNVKEEGkvkcqqywpdsdtkdygpfsvtlsdeqvlteyiirkihltllgSDQPPLMITQYHFTSWPDHGVPEYATSI
. .. ||| .|.||..  |.|||..||                                               .    ..|.||| |||..||....|.
aaslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssl

LQFHRRIKNEYKPTKGPMLVHCSV
|.| . .| ..     |...||| 
lkfikevkadfGqythpliihcsa
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 952-1225 1e-34 114.7 In-house 31-285 (297) alignment 
Range on Protein: 952-1225
Range on HMM: 31-285/297.0
PSNKLLNRFANIVVYDDNRIILRPISGHKDcpngYINACYVDGY--SDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSD
.|    ||. .|. .||.|. |.     .|    |||| ||       ...|| .|||.|.|| ||| ||...   |||||....|.|. ||  |||...
nsslrknryrdilatddtrvkllrviterd....yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

TKDYGPFSVTLSD-EQVLTEY---IIrkIHLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYkpTKGPMLVhcsvtqfqvtnwdstGE
 .     .| .    ..  |.   |.    |.|.  ..   ...   | ||||||||     . .|. .. .       ||..               . 
qerlkagdvvveflsstsdefdrvil..telqliyrse.srvvrhvqflswpdhGvpsdledlvrfqaqvcscc..iavpmml...............al

VKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
|.   .....  | .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.   .
vemftamvflqleslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfe
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 915-1132 1.6e-34 114.1 In-house 7-221 (439) alignment 
Range on Protein: 915-1132
Range on HMM: 7-221/439.0
FGEFVANGHVKGNEGFKNQFMMLDSGESDHTATVGL--TPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSDEYQYIATQGPVSKTV
| | | . . . .| ||. | ...| . |...   |     ..  ||. ... .|  |..|. | |       |||| |..|| |.  |||||||  .|.
fqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvph..shyinanyikGyyddklyiatqgpkkett

VDFWCLVWQERPPVIVMVTNVKEEGKvkcqqYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTL-LGSDQPPLMITQYHFTSWPDHGVPEYATSILQF
 ||| ||....   |||.||. |  |     ||| ..   ||  .|    .  | .|.|| ...     . .    . |.|...|||. ||  |. .|.|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

HRRIKN-EYKPTKGPMLVHCSV
 | |.  . |   ||..|||| 
lrainsandkeeygpvvvhcsa
0051429 (Phosphotyrosine protein) phosphatases II 984-1131 6.5e-32 106.6 In-house 4-158 (272) alignment 
Range on Protein: 984-1131
Range on HMM: 4-158/272.0
NGYINACYVDGYsdeYQ------YIATQGPVSKTVVDFWCLvWQERPPVIVMVTNVKEEGKVKCQQYWP------------DSDTKDYGPFSVTLSDEQV
.||||| .|.||   ..      .....||   |. ||| | ....  .||..... | |..|| .|||            .  |  || ..|||  |..
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYAtsILQFHRRIKNeykptKGPMLVHCS
|. ||.|.. |||| | . .......|.|.|||||||. |  .|.. . . .     .||.|||||
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1132-1222 1.4e-30 101.1 In-house 190-280 (301) alignment 
Range on Protein: 1132-1222
Range on HMM: 190-280/301.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|.|.|||.|   | |..|.|.|......  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.|  
vlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLe
subfamily_CG42327_pd Subfamily CG42327 952-1221 2.1e-30 100.5 In-house 26-301 (319) alignment 
Range on Protein: 952-1221
Range on HMM: 26-301/319.0
PSNKLLNRFANIVVYDDNRIILRPIsGHKDcPNGYINACYVDGYSDE-YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDT
.. |  .|..|.|   . |..|. | | .|  . |..| || || |   .|||.| .  ..  ||| .||. .  ||| .|.. | |  .| .|.| ..|
vtskdksrvinvvPlPetrvvlqri.gddd.kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket

KD----YGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpPLMITQYHFtSWPDHGVPEYATSILQFHRRIKNE---YKPTKGPMLVHCSVTQFQVTNWDS-
 |    || . ||| . .|  .|.|  . |  .  ..    .| | .  |.. .||   ....    ....    |   .   | . |.|     . |. 
ldntslyGdilvtlkgrevkdryaistlllkrvdkee.srelthywy.kwleaevPaeeaaliamllevrsslksysleqanelreksatletsmdadgs

TGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTV
  |. .  .  .  .   |. ..  .  .|||||| |||. .  |.  .|.. ..    .|. |.. | | ..  .|.|.
kaeagstssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltk
subfamily_ptpA1_pd Subfamily ptpA1 922-1132 7.5e-29 95.7 In-house 15-238 (418) alignment 
Range on Protein: 922-1132
Range on HMM: 15-238/418.0
GHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDGYSdEYQYIATQGPVSKTVVDFWCLVWQ
 |.|     |..| .|.       .. |    |   ||..||.  .  |. |. |  ..   . |||| |.||     |.|.||||. .|. ||| .||.
nhikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkeg..sdyinanyidgay.pkqfictqgplpntiadfwrmvwe

ERPPVIVMVTNVKEEGKVKCQQYWPDSD-----------TKDYGPFSVTLSDE--QVLTEYIIRKIHLTLLGSDQpplMITQYHFTSWPDHGVPEYATSI
.|  .|||..   |. ..||..|||.              . .| .|| | .   .   | | |.|.||. |  .    ||||..  |||| .|...  .
nrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetr...ditqyqyegwpdhnipdhtqpf

LQFHRRIKNEY---KPT---KGPMLVHCSV
 |. . | |      |.   . |..|||| 
rqllhsitnrqnqiipssdrnvpiivhcsa
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 941-1190 1.6e-28 94.5 In-house 36-284 (350) alignment 
Range on Protein: 941-1190
Range on HMM: 36-284/350.0
ESDHTATVGLTPSNKllNRFANIVVYDDNRIILR----P--ISGHKDCPNGYINACYVDGY------SDEYQYIATQGPVSKTVVDFWCLVWQERPPVIV
  |   . |.    |  ||. ||. |. .|..|.    .     |   .| |||| |.           ...|||||.|. .|| ||. .. .   .||.
snDvilseGvelfak..nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvil

MVTNVKEEGKVKCQQYWPDSDTKDygpFSVTLsdeqvlteyiiRKIHLTLLGSDQPPLMITQYHFTSW------PDHGVPEYATSIlQFHRRIKNeykpt
..|.  | .  ||..||.. . .|   . | |              .    | ..  |. .. . ..        |. .... . . .      .     
sltsdvelnlekcyrYWqegsydd...itvkl...........askwenimgindsslysadvkkeasdndnisddndlkdnnslt.aitlaasd.....

kgPMLvhcsVTQFQVTNWDSTGEVKNPQTILMIME--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAAT
  |.     | |.|| ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....   
..Pyv....vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDs
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 957-1132 5e-28 92.6 In-house 59-225 (290) alignment 
Range on Protein: 957-1132
Range on HMM: 59-225/290.0
LNRFANIVVYDDNRIILRpisghKDCPNGYINACYVDGYSDeyQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTK--DYG
 ||. ..|  |  |.||.        .  |. | ||.|      .| |||.. .||.|.| .| ||.  .|||. .. |.|| ||.||.|. . .   .|
knrykdvvcndktrvilk.....dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

PFSVTLSDEQVLTEYIIRKIhLTLLGSDQP-PLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSV
 ..|. | |.   . ||.|. |..   |.    ..  ..  ||||. |.  . ..|.  | ...    . ||. |||| 
eitvlcseeddkdaniikkt.lsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsa
0041856 (Phosphotyrosine protein) phosphatases II 954-1131 1.6e-27 91.6 In-house 1-117 (182) alignment 
Range on Protein: 954-1131
Range on HMM: 1-117/182.0
NKLLNRFANIVVYDDNRiilrpisghkdcPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTnvkeegkvkCQQYWPdsdtkdy
|. .||. .|. || .|            .. |||| ...|.    ..||||||  .|| ||. ......  .||..|         . .|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

gpfsvtlsdeqvlteyiirkihltllgsDQPPLMITQYHFTSWPDHGVPEyATSILQFHRRIKNeykpTKGPMLVHCS
                            .  . ...||....|||||||.   ..|.| .....     .|| |||||
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCs
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 917-1132 4.8e-27 89.5 In-house 11-228 (305) alignment 
Range on Protein: 917-1132
Range on HMM: 11-228/305.0
EFVANGHVKGNEGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILrpisgHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFW
.|| .   || .|....|. .   .  .         ..  ||. ..   |.||. |     .   |  || | ||   ..  ..| || |. ||  |||
kfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl.....egpwpheyihanyvstptnpkrfictqaplektcadfw

CLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDtKDYGPF-----SVTLSDEQ-------VLTEYIIRKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEY
 . .|..   | |. |..| |  ||..|..  | ||   |      ...  |          ..  ...  |.. |. .  . .|.||.  ||| |||  
ymclqdkveaifmlcnllekgakkcleyfaskd.kdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaa

ATSILQFHRriknEYKPTKGPMLVHCSV
 ..||..      . .|.|||. |||| 
dlailelle....karpskgpivvhcsa
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1131-1221 4.9e-26 86.6 In-house 179-269 (305) alignment 
Range on Protein: 1131-1221
Range on HMM: 179-269/305.0
SVTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|.|.|.|.|   | .. . ..| ..... ..|.|  .....||||..|||. .|.|    ....|.|.|.|||.|||  | .... ||| 
tvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 928-1132 4e-25 83.0 In-house 11-209 (281) alignment 
Range on Protein: 928-1132
Range on HMM: 11-209/281.0
EGFKNQFMMLDSGESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRPISGHKDCpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVI
. ||..|  |        .||   | |.  ||..|| . |  |. |.     |.    || | |.     .  || ||||  .|  ||| ..|||    |
ddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnkns.tdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMVTNVKEEGKVKCQQYWPDSD--TKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgP
||. .. |  . || .|.|       ..  .||.  |  |    .  .. |.  |  .   .||.. .  |||  ||| .  .|.  |.|.        |
vmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetr...lithwlwkewpdwqvpessevmlkilrkirarst....p

MLVHCSV
 ..||| 
pvihcsa
0036282 (Phosphotyrosine protein) phosphatases II 984-1131 4.2e-25 83.9 In-house 2-112 (174) alignment 
Range on Protein: 984-1131
Range on HMM: 2-112/174.0
NGYINACYVDGYSDEYQYIATQGPVSktvvdFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDsdtkdygpfsvtlsdeqvlteyiirkihltllGSDQ
. |||| ..|..     .||.||| .     || ......  ..||... || |..|| .|||.                                 .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

PPLMITQYHFTSWPDHGVPEYATsILQFHRRIKNEYKP-TKGPMLVHCS
.  .. ||... |||||||. .. .|.| ..... ..   .||.|||||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCs
0049772 (Phosphotyrosine protein) phosphatases II 942-1131 6.1e-25 84.0 In-house 34-220 (314) alignment 
Range on Protein: 942-1131
Range on HMM: 34-220/314.0
SDHTATVGLTPSNKLLNRFANIVVYDdNRIILrPISGHKDcpNGYINACYVDGYsdeYQYIATQGPVSKTVVDF----------WCLV--WQERPPVIVM
...| .|.  . |.  ||. .|. .| || || |  ....   .|||| ||||.    ..|||||| . |||||          | .|  .. .. .|||
peltilvadlflnrdknryldilpad.nrvil.pglpvsg..sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------VTNVKEEGkvkcqQYWPDSDTKDYGpfsvtlsdeQ-------VlteyiirkihltllgsdqpPLMITQYHFTSWPDHGV
                      ... . |      ... .| ...          .       .                   . .. .|. . .||...
srdevladelsrLdaAlgKtpllildgng.....neptaadlellk.........eelydpelf...................erlgikylripvpDgsa

PeYATSILQFHRRIKNEykPTKGPMLVHCS
|     ...| . |..   ...|| ||||.
p.lledfdeflefieea..dkggpvlvHCk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 917-1133 2.5e-24 80.4 In-house 16-233 (310) alignment 
Range on Protein: 917-1133
Range on HMM: 16-233/310.0
EFVANGHVKGNEGFKNQFMMLDSgESDHTATVGLTPSNKLLNRFANIVVYDDNRIILRpIsgHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFW
.|.      | ||. .|.  ||. . | . |      .   ||....|. |. |. |. |   |   . || | ||        .| .|||. .|..|||
nfiiateklgieglvkqyrklda.kqdssltyeaykkymhknrysdvvcldtsrvklk.i..dksryedyihanyvktnylrstficsqgplqhtiidfw

CLVWQERPPVIVMVTNVKEEGKVKCQQYWPDS-DTKDYGPFSVTLSDEQVlTEYIIRKIHLTLLGS-----DQP----PLMITQYHFTSWPDHGVPEYAT
 ...|||   |... .| |||. ||  |||    |. ||   ||   |    |. | .. .|..       .||     | ..  ..  ||| |||.   
rmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc

SILqfHRRIKNEYKptKGPMLVHCSVT
  .   .|.  . .  .|| .||||  
htv..pqrllaqvr..hgpcvvhcsag
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 927-1132 4.6e-24 80.0 In-house 15-218 (307) alignment 
Range on Protein: 927-1132
Range on HMM: 15-218/307.0
NEGFKNQFMMLDSGESDhTATVGLTPSNKLLNRFANIVVYDDNRIILRpISGhkdCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPV
 . ....| .|   . . . ||    .|   ||. .. . | .||... ..|       || | |.    .  ..|..|||  .|. .||... ||.   
vqalvdefrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvk.fdg...lasdyihanylgiaikpkkficaqgplentqysfwamaiqekves

IVMVTNVKEEGKVKCQQYWPDSD--TKDYGPFSVTLSDEQVLT------EYIIRKIHLTLLGsDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
..|. .| | .|.||.||||  .  .. .|  . |.| ... .      | .|    | .    |    |... .. |||.|||.   . . .   .. .
vimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltainlleavryd

ykptKGPMLVHCSV
    . |..|||| 
....tnpvvvhcsa
0046846 (Phosphotyrosine protein) phosphatases II 982-1131 5.6e-24 80.3 In-house 10-117 (176) alignment 
Range on Protein: 982-1131
Range on HMM: 10-117/176.0
CPNGYINACYVDGYsdeyQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDsdTKDYGPfsvtlsdeqvlteyiirkihltllgs
 .  |||| ...|.     .||||||. .|. ||. ......  ..|..|. .| |..|| .|||.   ...|                           
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..........................

dqpplmitQYHFTSWPDHGVPEYaTSILQFHRRIKNEYKPTkGPMLVHCS
        ||... |||||||.. . .|.. . |.. .|   || |||||
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCs
0043147 (Phosphotyrosine protein) phosphatases II 984-1131 8e-23 76.4 In-house 5-108 (172) alignment 
Range on Protein: 984-1131
Range on HMM: 5-108/172.0
NGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVkeegkvkcqqywpdsdtkdygpfsvtlsdeqvlteyiirkihltLLGSDQ
. |||| |.|.|    ..|||||| . |. ||| .....   .||..|.                                             |.  ..
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpel

PPLMITQYHFTSWPDHGVPeYATSILQFHRRIKN-EYKPTKGPMLVHCS
   .. ||....|||||||  .  .|.| . |..   .  .||.|||||
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCs
0049260 (Phosphotyrosine protein) phosphatases II 991-1131 1.6e-22 75.2 In-house 1-97 (152) alignment 
Range on Protein: 991-1131
Range on HMM: 1-97/152.0
YVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWpdsdtkdygpfsvtlsdeqvlteyiirkihltllgsdqpplmitQ
..|||   ...|||||| . |. ||| ....    .|||.|.  | ||.|| ||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCS
|... |||||||. .  .|.... |.  ..  .|| |||||
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCs
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 944-1131 3.1e-22 73.9 In-house 21-200 (267) alignment 
Range on Protein: 944-1131
Range on HMM: 21-200/267.0
HTAT--VGLTPSNKLLNRFANIVVYDDNRIILRPISGHkdcpngYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEgkvKC
 ..|    ..  |.  ||. . . |||.|.|||           |||| ||.||  . ..|.||.|...|. ||. .. ... ||||..|.| ..   . 
tsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...ni

QQYWPDS--DTKDYGPFSVTLSDEQVLTEYIIRKIHLTLlgSDQPPLMITQYHFTSWPDHGVPE-YATSIlqFHRRIKNEYKPTKGPMLVHCS
...||    ..| |  ..|  | |.   .| |  . | .   ..    .| |..  |      . |   .  |    ||. .    |..|.||
rlfwPPkmgqakkyqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacs
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1132-1221 5.8e-22 73.3 In-house 187-276 (298) alignment 
Range on Protein: 1132-1221
Range on HMM: 187-276/298.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| |...|.| . |. .| ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| 
vrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1132-1221 8e-21 69.2 In-house 164-252 (283) alignment 
Range on Protein: 1132-1221
Range on HMM: 164-252/283.0
VTQFQVTNWDSTGEVKnPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. .|| .| . ||   .   |. .. .   |..  .. |||||| ..||.|.|.||...... .|| |.|||.|.|  | |... ||| 
lahyqvidWleygeqa.iinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl
subfamily_PTPRD_pd Subfamily PTPRD 1132-1220 2.1e-20 67.9 In-house 179-266 (564) alignment 
Range on Protein: 1132-1220
Range on HMM: 179-266/564.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
|.||. |.| ..|  ......| ..... ... ....  ||||||  |||. .|..    ... |.|...|..|..|  | |..  |||
VrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt
Y_phosphatase Protein-tyrosine phosphatase 1132-1221 4.4e-20 67.5 Pfam-A 135-223 (235) alignment 
Range on Protein: 1132-1221
Range on HMM: 135-223/235.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|...|||   |  ..|. .| ..... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
vkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
Y_phosphatase Protein-tyrosine phosphatase 1132-1221 4.4e-20 67.5 In-house 135-223 (235) alignment 
Range on Protein: 1132-1221
Range on HMM: 135-223/235.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|...|||   |  ..|. .| ..... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
vkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 953-1133 1.1e-19 65.6 In-house 34-213 (285) alignment 
Range on Protein: 953-1133
Range on HMM: 34-213/285.0
SNKLLNRFANIVVYDDNRIILRpisghkDCPNGYINACYVDG-YSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDS--D
.|  |||.|.. . .. |..|.      .    || | ..     |.  ||.||||. .|. ||| ...||.   ..|.  . | |  ||  |.|.   .
anpdlnryadvrcieetrvvlk......nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

TKDYGPFSVTLSD--EQVLTEYIIRKIHLTLL-GSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKGPMLVHCSVT
   .| . .||..  |. ..  |.  . ..    .   || . . .   |||.  || |  ...... .|.  .| . |. ||||  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsag
0050432 (Phosphotyrosine protein) phosphatases II 1132-1222 1.1e-19 66.4 In-house 199-286 (308) alignment 
Range on Protein: 1132-1222
Range on HMM: 199-286/308.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
||.|. |||   |   .|. .| ..|.. ...   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||. 
vthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 957-1132 1.4e-19 64.9 In-house 58-230 (305) alignment 
Range on Protein: 957-1132
Range on HMM: 58-230/305.0
LNRFANIVVYDDNRIILrpisgHKDCPNGYINACYVDG-YSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGP
 ||.... . | . . |     .|  |  || | ||      | ..|..|||. .|. .|| .| |..   |||. .  | ||.|| |||| .  .    
knryqdvpcqdqsavkl.....dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

FSV----TLSDEQVL---TEYIIRKIHLTLlgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSV
 |      .|  . .   .|  |  ..||   | .  . . . ..| ||| |||    . |..   |.     .| |..|||| 
ksgivvenvsgskpmerdaeiqitllnlty..sgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsa
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1132-1220 1.4e-19 65.3 In-house 177-265 (318) alignment 
Range on Protein: 1132-1220
Range on HMM: 177-265/318.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
| |...|.|  .|  ... ..| .. .  ..|.| |.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  |||
vrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt
0051082 (Phosphotyrosine protein) phosphatases II 984-1131 2.7e-19 64.7 In-house 3-100 (151) alignment 
Range on Protein: 984-1131
Range on HMM: 3-100/151.0
NGYINACYVDGYsdeyqYIATQGPVSktvvDFWCLVWQERPPVIVMVTNVKEEGkvKCQQYWPDSDtkdygpfsvtlsdeqvlteyiirkihltllgsdq
..|||. ||.|.     .....|| .    ||. |....   .||.... .| |  .| .|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

ppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykPTKGPMLVHCS
  . ........|||.|.|..  ..|.|.. . .   . .||.|||||
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCs
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1132-1221 2.9e-19 64.3 In-house 139-228 (250) alignment 
Range on Protein: 1132-1221
Range on HMM: 139-228/250.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| |.. ..|   |  .. ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |.| |.|||.|.|  |...|..|.. 
vrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesl
0046845 (Phosphotyrosine protein) phosphatases II 1132-1222 5.4e-19 64.1 In-house 167-261 (284) alignment 
Range on Protein: 1132-1222
Range on HMM: 167-261/284.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVV
||.|..|.|   |   .|. .| ..... . ...  |.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||. 
vthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
0051299 (Phosphotyrosine protein) phosphatases II 1132-1221 5.9e-19 64.0 In-house 184-272 (288) alignment 
Range on Protein: 1132-1221
Range on HMM: 184-272/288.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
||.|..|||   |   .|. .| ....... ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||.
vthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0036941 (Phosphotyrosine protein) phosphatases II 1132-1221 6.5e-19 63.8 In-house 170-263 (297) alignment 
Range on Protein: 1132-1221
Range on HMM: 170-263/297.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTV
||.|..|.|.  |   .|...| ..|.. . ...  ... ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||.
vthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1132-1221 7.1e-19 63.0 In-house 180-269 (319) alignment 
Range on Protein: 1132-1221
Range on HMM: 180-269/319.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|..|| |.|   .  .. ...| ..... ....|  .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||. 
vkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp
0047943 (Phosphotyrosine protein) phosphatases II 1132-1221 1.4e-18 62.8 In-house 168-258 (273) alignment 
Range on Protein: 1132-1221
Range on HMM: 168-258/273.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
||.|..|.|   |   ... .| ..|.. .....  .|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||.
vthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp
PTPc_DSPc_SM00012 1132-1221 1.6e-18 62.2 In-house 2-93 (105) alignment 
Range on Protein: 1132-1221
Range on HMM: 2-93/105.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTV
|.....|.|  .|  .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 987-1131 1.9e-18 61.3 In-house 78-222 (301) alignment 
Range on Protein: 987-1131
Range on HMM: 78-222/301.0
INACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSD--TKDYGPFSVTLSDEQ-VLTEYII-RKIHLTLLGSD
| | ...   .  ..||||||...|  ||| .. |     |||...  |. . ||..| | .   . | | |.... ... .| . |. |.....    .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

QPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCS
 ..  .| | ...|.|.|||.  . . ..   .|.    .. |..||||
fatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcs
0040438 (Phosphotyrosine protein) phosphatases II 1132-1221 2.1e-18 62.1 In-house 174-262 (317) alignment 
Range on Protein: 1132-1221
Range on HMM: 174-262/317.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
||.|. |.|.  |  ..|...| ..|.. . .. .... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| 
vthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp
0044763 (Phosphotyrosine protein) phosphatases II 966-1131 2.8e-18 61.7 In-house 2-118 (178) alignment 
Range on Protein: 966-1131
Range on HMM: 2-118/178.0
YDDNRIILRPISGHKDCPngYINACYVDGYsdeyQYIATQGPvsktvVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTkdygpfsvtlsdeqv
.|..| .| ...|.  ..  ||||......     |.....|     .|.. |....   .||..|. .| |..|| .|||..                 
ldrtrvllsnleglersd..yinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

lteyiirkihltllgsdqpplmiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCS
                        ||... .||||||.    .|.|.. |.. ... .|| |||||
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCs
subfamily_PTPRA_pd Subfamily PTPRA 1132-1222 3.4e-18 60.6 In-house 193-282 (330) alignment 
Range on Protein: 1132-1222
Range on HMM: 193-282/330.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|.||  | |   |   .|. .| ..... ..... .. .||||||  |||.  |..  . ... |.|...|||...|. | |.|  |||  
vrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtde
DSPc_SM00195 1132-1221 5.2e-18 60.7 In-house 160-248 (263) alignment 
Range on Protein: 1132-1221
Range on HMM: 160-248/263.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|||.|..||   |  .... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
vtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
PTPc_SM00194 1132-1221 5.2e-18 60.7 In-house 160-248 (263) alignment 
Range on Protein: 1132-1221
Range on HMM: 160-248/263.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|||.|..||   |  .... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
vtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
0045450 (Phosphotyrosine protein) phosphatases II 1132-1221 8.5e-18 60.6 In-house 197-290 (307) alignment 
Range on Protein: 1132-1221
Range on HMM: 197-290/307.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
||.|. |.|  .|  ......| ..||. . ...  ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||. 
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp
0039614 (Phosphotyrosine protein) phosphatases II 1132-1221 3.7e-17 58.2 In-house 185-275 (297) alignment 
Range on Protein: 1132-1221
Range on HMM: 185-275/297.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
||.||.|.|   |   .....| ..|.. . ...  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| 
vthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp
0042113 (Phosphotyrosine protein) phosphatases II 1132-1221 7.8e-17 57.0 In-house 140-229 (245) alignment 
Range on Protein: 1132-1221
Range on HMM: 140-229/245.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.... ..|.  |.  .....| ..|.. . ... .|. ..||||. |||...|.|| . ..  ..|. .......|  | |.||.||| 
vihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtp
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 999-1134 1.3e-16 55.3 In-house 5-146 (199) alignment 
Range on Protein: 999-1134
Range on HMM: 5-146/199.0
YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPD--SDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPP-LMITQYHFTS
 .||||| |. .|. ||| .||.     |||| . . . ..    |||   | |  || .|||     .  .| |  . ||   .  |    |..| |||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSVTQ
| ..  |. |    ..   | . . |.  |  |..||||  |
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 999-1134 1.4e-16 55.2 In-house 4-145 (198) alignment 
Range on Protein: 999-1134
Range on HMM: 4-145/198.0
YQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPD--SDTKDYGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQPP-LMITQYHFTS
 .||||| |. .|. ||| .||.     |||| . . . ..    |||   | |  || .|||     .  .| |  . ||   .  |    |..| |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSVTQ
| ..  |. |    ..   | . . |.  |  |..||||  |
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 953-1131 2e-16 54.8 In-house 42-212 (288) alignment 
Range on Protein: 953-1131
Range on HMM: 42-212/288.0
SNKLLNRFANIVVYDDNRIILRpisghkDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKD
.|   .|. |.   |  |. |       | |. ||.|  |     . . | .| |.  |.  .| .. ..    |||.... | || | ..|.|    . 
anptrdryenlprcditrvkls......ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

yGPFSVTLSDEQVLTEYIIRKIHLTLLGSDQP---PLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCS
   .    .. ..  . | . ....||   ..   . .. . |.  |.|.||||   | |..  ..|.  |    |..||.|
.arigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....Pivvhss
0043336 (Phosphotyrosine protein) phosphatases II 1132-1221 3.6e-16 54.9 In-house 175-263 (278) alignment 
Range on Protein: 1132-1221
Range on HMM: 175-263/278.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
||... ..|   |   .....| ..... . ..   |. ..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.||| 
vthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp
subfamily_egg_pd Subfamily egg 953-1221 8.1e-16 52.6 In-house 39-256 (307) alignment 
Range on Protein: 953-1221
Range on HMM: 39-256/307.0
SNKLLNRFANIVVYDDNRIILRPISGHkdCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEgkVKCQQYWPDSDT--
 |.   |   .   |  |. |.   |     . .| | .|.|     ..| .| |.  || ||| .|.||. . |||.|  ||    .|. ||| ...  
nnlekarskrvhckdssrvklelrrGq..ylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

KDY--GPFSVTLSDEQVLTEYIIRKIHLTLLGSDqpplmitqyhftswpdhgvpeyatsilqfhrrikneykptkgpmLVHCSVTQFQvTNWDSTGEVKN
  .  | . ..  . .  .. . |  .| |.|.|                                                 .  .|  ... ...|  
lvtvpGslrienlkvdskadplfrvtklklvGgd............................................deerflehwq.gdvnnssdvys

PQTILmimeemyRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTV
|  .|       |  |.   . .||.. . | ..| . |. ... .    | |  . ||..    | ... ||..|
plrvl.......rklrnl.skpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesv
0040439 (Phosphotyrosine protein) phosphatases II 1132-1221 2e-15 52.6 In-house 142-232 (249) alignment 
Range on Protein: 1132-1221
Range on HMM: 142-232/249.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|...|.|.|  .|  ......| ..|..   ...   .. ..||||. |||...|.|| . ..  ..|. .|.....|  | |.||.||. 
vlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp
0045098 (Phosphotyrosine protein) phosphatases II 1132-1221 3.6e-15 51.6 In-house 156-258 (278) alignment 
Range on Protein: 1132-1221
Range on HMM: 156-258/278.0
VTQFQVTNWDSTGEVKNP--QTILMIMEEMYRTQR------------KRGNTSIVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-
||... ..|.  |   .|  . .| ..|.. . ..              ... ..||||  |||.....|| . .  .  ||..|.....|  | |.|| 
vthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpgl

SVQTV
.||. 
avqnl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1154-1221 9.9e-15 49.2 In-house 178-245 (267) alignment 
Range on Protein: 1154-1221
Range on HMM: 178-245/267.0
MIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 ..  . . | . ||  .||.||| ||||  |  . . ... ||||| |.|. |.  | |..| |.| 
plfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk
subfamily_Ptp69D_pd Subfamily Ptp69D 1132-1221 1.6e-14 48.8 In-house 184-272 (307) alignment 
Range on Protein: 1132-1221
Range on HMM: 184-272/307.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|.. |.|. .   . ....| ..|...  ...  .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  ||  
vvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsl
subfamily_PTPRK_pd Subfamily PTPRK 1132-1221 1.9e-14 48.2 In-house 175-263 (314) alignment 
Range on Protein: 1132-1221
Range on HMM: 175-263/314.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| ||| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||. .|.| .. ..  ..|||.|||.. |. | .|.  |.| 
vrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvete
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1131-1225 2.2e-14 48.6 In-house 150-245 (284) alignment 
Range on Protein: 1131-1225
Range on HMM: 150-245/284.0
SVTQFQVTNWDSTGEVKNPQTILMIMEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
...||    |   |  . |  ......   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  .
kirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1131-1224 2.9e-14 48.1 In-house 186-280 (319) alignment 
Range on Protein: 1131-1224
Range on HMM: 186-280/319.0
SVTQFQVTNWDSTGEVKNPQTILMIMEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSV
..|||    |   |  . |  ......   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  
kitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1131-1222 3.3e-14 47.8 In-house 179-275 (325) alignment 
Range on Protein: 1131-1222
Range on HMM: 179-275/325.0
SVTQFQVTNWDSTGEVKNPQTILMIMEEMYR---TQ--RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|| |||.  ||  |  | | |.. |.. .     .     .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.|| 
svkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1132-1220 3.8e-14 46.7 In-house 174-261 (515) alignment 
Range on Protein: 1132-1220
Range on HMM: 174-261/515.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
||||. |.|   |  |. ...| .. |. .... . . ....|||  |||  .....   . . ||  ..|||....  | ..|  |||
vtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqt
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 955-1132 4.1e-14 47.0 In-house 44-218 (312) alignment 
Range on Protein: 955-1132
Range on HMM: 44-218/312.0
KLLNRFANIVVYDDNRIILrpiSGHKdcpNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSdtKDYg
| |||. || ..|  |. |   .| .   | || | .|   .   ....||||. .|.. || |.       |.... . |.|  || .|  |     . 
kdlnrypniqcwdrgrftl...agde...nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi..vgf.

pfsVTLSDEQVLTEYII-------------RKIHLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSV
   | | | .| |||                ..   .. .      . .| ..||||||.|.   . |..   .|..    | |.. ||| 
...vdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkd....kkpviahcsa
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1132-1220 4.4e-14 47.1 In-house 175-262 (315) alignment 
Range on Protein: 1132-1220
Range on HMM: 175-262/315.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
||||| |.|   |  |.  ..| .. |.    ... . |..||||  |||. .....   ... | . ..|||...|  | ..|  |||
vtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt
0036282 (Phosphotyrosine protein) phosphatases II 1132-1220 1e-13 46.8 In-house 69-155 (174) alignment 
Range on Protein: 1132-1220
Range on HMM: 69-155/174.0
VTQFQVTNWDSTGEVKNPQtILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQT
. |.. ..|.  |.   .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||
giqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
0037934 (Phosphotyrosine protein) phosphatases II 1132-1221 1.3e-13 46.6 In-house 135-228 (243) alignment 
Range on Protein: 1132-1221
Range on HMM: 135-228/243.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTV
|.... ..|   |   .|. .| ...|..  ...        ..  ..||||  |||.....|| . . ..   | .|.....|  | |.|| .||| 
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtp
fn3 Fibronectin type III domain 501-571 1.9e-13 43.5 Pfam-A 12-84 (85) alignment 
Range on Protein: 501-571
Range on HMM: 12-84/85.0
NPDAINIVWKIPTVPNGIITVYEIKYRESTSTG-PYNITNTTNT-YYNIAGLIPNTSYTIGVRAYTSIGPGEW
... ... |. |. ..| || ||..|||..... . ..|.. .|  ... || |.|.|.. |.|..  | |..
tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1132-1221 2.5e-13 44.8 In-house 179-270 (297) alignment 
Range on Protein: 1132-1221
Range on HMM: 179-270/297.0
VTQFQVTNWDSTGEVK--NPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| |.| ..| .  . .  . ...| ...|.  .  .. .. ..|||.  ||| .....    . . | |  .|.|...|  | ..|  ||| 
vkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1132-1223 2.6e-13 44.6 In-house 177-267 (315) alignment 
Range on Protein: 1132-1223
Range on HMM: 177-267/315.0
VTQFQVTNWDsTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
| |...| |  . .| .  . || .    .  ..   ..||||||. |||.  |..  . ... ..| .|||.....  | .. . ||..  
vvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeq
I-set Immunoglobulin I-set domain 802-888 3.4e-13 41.2 Pfam-A 1-90 (90) alignment 
Range on Protein: 802-888
Range on HMM: 1-90/90.0
PVIEEFPNDVTTEEGREVLLKVKVNETTKLCFNWYHNGDPVTEDYAHELRGDG---SLLLVSVEEKHKGAYRFVANNDAGTVSQQVVLTV
|.... ..||...|| .| |...|... .. ..|...| .....  .... ..   .| . .||.. .| |. .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1132-1224 3.5e-13 44.3 In-house 172-265 (281) alignment 
Range on Protein: 1132-1224
Range on HMM: 172-265/281.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVSV
|.|.. |.|  .|  .... .|   .|......|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||||  
veqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1009-1131 4.5e-13 43.9 In-house 38-156 (255) alignment 
Range on Protein: 1009-1131
Range on HMM: 38-156/255.0
SKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTL-LGSDQPPLMITQYHFTSWPDHGVPEYATS
| ||  |.  . | .. |.||... .|||..||..|.|    .      |...  .  .. ..| ...|. ||  .    .. |... |...  || |  
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

ILQFHRRIKNEyKptkgPMLVHCS
||.  . ...  |    ...||||
ilnilkvvrds.k....svvvhCs
fn3 Fibronectin type III domain 394-477 4.9e-13 42.2 Pfam-A 2-83 (85) alignment 
Range on Protein: 394-477
Range on HMM: 2-83/85.0
PVDDIIFSSVESVSMTVSWDEAPcnGRNGPITGFYLTYTNITSNT-SYTINITGGDNrMYNLTGLIPYTNYTVSIIPYNYNMNGP
.. .. .|.| | |.|.||.. .   ..|||||. ..| . ...  . ......  .  ..|||| |.|.|....  .| . .||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1132-1222 9e-13 42.9 In-house 177-266 (288) alignment 
Range on Protein: 1132-1222
Range on HMM: 177-266/288.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.||.| . |  .|  .. . .| ... .  .. .     |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||. 
itqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 965-1131 9.4e-13 42.9 In-house 29-199 (290) alignment 
Range on Protein: 965-1131
Range on HMM: 29-199/290.0
VYDDNRIILRPIsgHKDCPNGYINACYVDgYSDEYQYIATQGPVSKT-------VVDFWCLVWQERPPVIVMVTNVKEEGKV----KCQQYWPDSDT--K
.  ..|..|.     |   ..|| | .|  ...  . |.|| |  |.       . .|| .. ||.   .||. ...|. .      |..| |.|     
LveatrvvLkgy..gkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel

DYGPFSVTLSDEQVLTEYIIRKIHLTLlgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCS
 .. ..|   .     . ..|.. ..    |. .. .| . . .| .  |.|   ..|.  . .|..    | |..||| 
kfkgltvkCkskekeddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcv
subfamily_PTPN23_pd Subfamily PTPN23 1132-1225 9.4e-13 42.6 In-house 173-270 (288) alignment 
Range on Protein: 1132-1225
Range on HMM: 173-270/288.0
VTQFQVTNWDSTGEVKNPQTILMIMEEM---YRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
|.  |.|.| . |  . |.|.| ...|.   |...... .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||..  ..
vshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk
subfamily_PTPRB_pd Subfamily PTPRB 1132-1222 1.1e-12 42.7 In-house 181-272 (293) alignment 
Range on Protein: 1132-1222
Range on HMM: 181-272/293.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQ-RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|.|.. | |   |  ....|.| ..... ... ..  .. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||. 
vrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtek
subfamily_PTPN12_pd Subfamily PTPN12 1132-1221 1.2e-12 42.3 In-house 172-263 (290) alignment 
Range on Protein: 1132-1221
Range on HMM: 172-263/290.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
|.||. |.|   |  ......| ..|.. |. ... .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  ||| 
vyqfhYtaWPDhgvPssaksllelielv.relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 950-1064 1.6e-12 41.6 In-house 92-199 (244) alignment 
Range on Protein: 950-1064
Range on HMM: 92-199/244.0
LTPSNKLLNRFANIVVYDDNRIILrpiSgHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEgkvkcQQYWPDSD
. |.|   || .  . .| ||. |   | .    | |||| .|       .|| || |.. | .||| .. .    |.|..  |.||     ..|||||.
fnpnnswknregaglpfdfnrvpl...s.kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse

TKDYG--PFSVTLSDEQ
  ..     .|||.| .
plewyeeditvtltdrd
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1132-1221 1.6e-12 42.1 In-house 163-254 (274) alignment 
Range on Protein: 1132-1221
Range on HMM: 163-254/274.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|. .  |.|  .   ....|.| ...|. ...... .   ..|||||  .||  .| |.  .... . |.|.||...    |... | ||| 
vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts
subfamily_CG7180_pd Subfamily CG7180 1132-1221 1.7e-12 41.6 In-house 182-276 (296) alignment 
Range on Protein: 1132-1221
Range on HMM: 182-276/296.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRG-----NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|..||.| |..  .|    . |. . .. |. |..      .  .||..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..|
vklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenv
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 911-1006 2.7e-12 40.7 In-house 6-95 (95) alignment 
Range on Protein: 911-1006
Range on HMM: 6-95/95.0
PVGQFGEFVANGHVKGNEGFKNQFMMLDSgESDHTATVGLTPSNKLLNRFANIVVYDDNRIILrpiSGHKDcpNGYINACYVDGYSDEYQYIATQG
 |  |   | . | . .. | |.|  .    |  . ||| . .|   ||| ||. ||  |..|   . ..|    |||||.||||.    |||.||
hvsvfhshvlemhsnsdqefdnefksism.tsgapytvgsseanipknrflnifpydatrvvl...ttkrd..sdyinacfvdgyarkncyiaaqg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 943-1049 3.4e-12 40.4 In-house 39-157 (349) alignment 
Range on Protein: 943-1049
Range on HMM: 39-157/349.0
DHTATVGLTPSNKllNRFANIVVYDDNRIILR----PISGH-------KD-CPNGYINACYVD--GYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIV
|   . |.    |  ||. .|. |.  |..|.    .  .        .   .. |||| |.    .| | .||||| |.  || ||. ..  .. ....
dvilseGvelfak..nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvl

MVTNVKEEGKVKCQQYWPDSD
 ... ||..  ||..|| . .
sLnddkelslekcdiywqels
subfamily_PTPRG_pd Subfamily PTPRG 1132-1220 3.7e-12 40.2 In-house 185-272 (563) alignment 
Range on Protein: 1132-1220
Range on HMM: 185-272/563.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
|.|.. |.|  .|  . .   |. ..   .....     ||||||  |||. ....  | ... ..| ...||..||  | |..  |||
vrqyhytkWPdhgvPehslpvLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt
0043147 (Phosphotyrosine protein) phosphatases II 1132-1230 8.5e-12 40.6 In-house 65-156 (172) alignment 
Range on Protein: 1132-1230
Range on HMM: 65-156/172.0
VTQFQVTNWDSTGEVkNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVVSVQLYLPY
. |.. ..|.  |   ... .| ..| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||.    .. . .
giqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyf
subfamily_eak_pd Subfamily eak 960-1116 1.7e-11 38.1 In-house 57-208 (332) alignment 
Range on Protein: 960-1116
Range on HMM: 57-208/332.0
FANIVVYDDNRIILRPisgHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSD--TKDYGPFS
  .|| || . . | .    .  ..|||||  ..      .|| |  .  . |  || .| ... | ||.. .  |..  | ..|.||      ..| . 
vvkivpydrylvrlts...sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VTLSDEqvLTEYIIRKIHLTLLgSDQPPLMITQYHFTSWPDHGVPEYAtSILQFHRRIK
|.  .   . . |..   | |         .  |..  | .  .| |    | ... .|
verkef..vkrniletrllels.kGnethrvlhykvfGwtettlpkye.dflalrkvmk
PTPc_DSPc_SM00012 1088-1131 4e-11 38.4 In-house 2-47 (105) alignment 
Range on Protein: 1088-1131
Range on HMM: 2-47/105.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK--GPMLVHCS
...||.|.||||||||...|||.. | .|....  .  .|..||||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCs
subfamily_hpo-7_pd Subfamily hpo-7 1010-1131 8.4e-11 36.2 In-house 45-162 (263) alignment 
Range on Protein: 1010-1131
Range on HMM: 45-162/263.0
KTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDSDTKDYGPFSVTLSDEQVLTEYIIRKIHLTL-LGSDQPPLMITQYHFTSWPDHGVPEYATSI
.|.  |.  . | .. |.||... .|||..||..|.|    .      |...  .|  . ... ..|.  ||  .    ...| .. |...  || | .|
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LQFHRRIKNEyKPtkgpMLVHCS
|.  .  .|  |.    . ||||
lnilkvarns.ks....lvvhcs
subfamily_PTPN6_pd Subfamily PTPN6 1132-1223 9.6e-11 36.2 In-house 188-285 (306) alignment 
Range on Protein: 1132-1223
Range on HMM: 188-285/306.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVVS
| |.. ..|   |  |.|...|  .|.. | |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | |||   
vfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqq
0048076 (Phosphotyrosine protein) phosphatases II 1053-1131 1.7e-10 36.2 In-house 13-89 (145) alignment 
Range on Protein: 1053-1131
Range on HMM: 13-89/145.0
YGPFSvTLSDEQVLTEYIIRK-IHLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTkGPMLVHCS
.|..  | .| . | .. |.  . ||   ..    ...||....|||||||. .  .|.| . |.. .|   ||.|||||
lgslp.taldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCs
subfamily_PTPN13_pd Subfamily PTPN13 1132-1220 3.9e-10 34.4 In-house 168-254 (273) alignment 
Range on Protein: 1132-1220
Range on HMM: 168-254/273.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
|.... ..|   |  .... .| .. |. | |.   .. ||||||  .||| .. .  . ..  . .  .|| ..... | |. | |||
vahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1133-1226 6.1e-10 33.5 In-house 155-255 (270) alignment 
Range on Protein: 1133-1226
Range on HMM: 155-255/270.0
TQFQVTNWDSTGEVK------NPQTILMIMEEMYRTQRKRGN-TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
. |. ..|   | ..      ... .| ..... |....  . . ..||||. |||. .. |  ....  .... .|| ....  | ...  ||... ..
vHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqye

L
.
f
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1133-1221 6.6e-10 32.9 In-house 92-180 (440) alignment 
Range on Protein: 1133-1221
Range on HMM: 92-180/440.0
TQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 |..   |   |  |    .| .....  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| 
kqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 993-1064 7.7e-10 32.7 In-house 230-299 (440) alignment 
Range on Protein: 993-1064
Range on HMM: 230-299/440.0
DGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEgkvKCQQYWPD-SDTKDYGPFSVTLSDEQ
.|||    .|||| |.  ||.||| || . |   |.|. ....     |  |||  . .  .|||.|     .
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgse
0049260 (Phosphotyrosine protein) phosphatases II 1134-1227 9.1e-10 33.9 In-house 56-142 (152) alignment 
Range on Protein: 1134-1227
Range on HMM: 56-142/152.0
QFQVTNWDSTGEVKNPQTILMIMEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVVSVQLY
|.. ..|.  |  ...| .|.... . .  ... .  ..||||  |||.....||   .        ........  | ..||.|..    .. 
qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl
0041856 (Phosphotyrosine protein) phosphatases II 1132-1221 1.1e-09 33.6 In-house 79-157 (182) alignment 
Range on Protein: 1132-1221
Range on HMM: 79-157/182.0
VTQFQVTNWDSTGEVKnPQTILMIMEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDVFQVLKSQRIQKPGSVQTV
..|.. ..|.  |    ....| ..||...      .  ..||||  |||.....||   . .    | .......|  | ..||.|.| 
giqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitp
0048076 (Phosphotyrosine protein) phosphatases II 1132-1221 1.1e-09 33.6 In-house 47-129 (145) alignment 
Range on Protein: 1132-1221
Range on HMM: 47-129/145.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVLKSQRIQKPGSVQTV
..|.. ..|.  |.   ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......|.  | | ||.|...
giqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp
0048179 (Phosphotyrosine protein) phosphatases II 1085-1131 1.4e-09 33.4 In-house 46-91 (144) alignment 
Range on Protein: 1085-1131
Range on HMM: 46-91/144.0
PLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCS
  ...||....|||||||.... .|.| . |.. ..  .||.|||||
eregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCs
subfamily_PTPRN_pd Subfamily PTPRN 1132-1223 1.9e-09 31.7 In-house 189-280 (297) alignment 
Range on Protein: 1132-1223
Range on HMM: 189-280/297.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGnTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVS
||||    | ..|   .....|     . .. | |  ..||||||| .||. ....    .|.  |    ||.   |.  | |.|| |.|   
vtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdq
0048179 (Phosphotyrosine protein) phosphatases II 1133-1221 2.1e-09 32.8 In-house 50-131 (144) alignment 
Range on Protein: 1133-1221
Range on HMM: 50-131/144.0
TQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTV
.|.. ..|.  |    .. .| ..| . . ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|.. 
iqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnp
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1132-1220 3.9e-09 30.4 In-house 280-370 (392) alignment 
Range on Protein: 1132-1220
Range on HMM: 280-370/392.0
VTQFQVTNWDSTGEVKNP--QTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
|||.|   |   |  ...  ...| ..  .  .  .. . ||.|||    ||. .||.|   | .      .|.|| .|  | ..  .|||
vtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqt
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 954-1040 4e-09 30.4 In-house 34-117 (332) alignment 
Range on Protein: 954-1040
Range on HMM: 34-117/332.0
NKLLNRFANIVVYDDNRIILRPISGHKDcpngYINACYVDGYSDEYQYIATQGPVS-KTVVDFWCLVWQERPPVIVMVTNVKEEGKVK
|  .||   . ..| .|. | |  |. |    . || .||||| .  || .| |.  .|   || .| . .| .|... .. |. | |
nmdmnriphlycfdhsrvelapqdgkdd....fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
0051429 (Phosphotyrosine protein) phosphatases II 1132-1222 4.3e-09 31.9 In-house 122-212 (272) alignment 
Range on Protein: 1132-1222
Range on HMM: 122-212/272.0
VTQFQVTNWDSTGEVKNPqtILMIMEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------VFQVLKSQRIQKPGSVQTVV
|.... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        ......  | | ||.|||  
vmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqtee
subfamily_PTPN9_pd Subfamily PTPN9 1145-1220 6.2e-09 30.3 In-house 188-275 (297) alignment 
Range on Protein: 1145-1220
Range on HMM: 188-275/297.0
EVKNPQTILMIMEEMYRT------------QRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
  .. ...| ..|.. ..            . .  .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.||
vPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqt
0046846 (Phosphotyrosine protein) phosphatases II 1134-1221 1.2e-08 30.4 In-house 78-159 (176) alignment 
Range on Protein: 1134-1221
Range on HMM: 78-159/176.0
QFQVTNWDSTGEVKNpQTILMIMEEMYRTQRKRgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTV
|.....|.  |     . .| ..|.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.||| 
qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 983-1063 1.4e-08 29.1 In-house 12-89 (130) alignment 
Range on Protein: 983-1063
Range on HMM: 12-89/130.0
PNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMVTNVKEEgkvkcQQYWPDSDTKDYGPFSV--TLSDE
 | |||| .|       .|. || |...| .||| .. .    |.|..  |.||     ..|||||.  ..    .  ||.| 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr
subfamily_PTPN3_pd Subfamily PTPN3 1132-1221 1.9e-08 28.6 In-house 173-261 (280) alignment 
Range on Protein: 1132-1221
Range on HMM: 173-261/280.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
..|.| ..|   |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  |.. .  ..  . . ....  | |.   |||.
ilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1006-1132 2e-08 28.1 In-house 98-230 (302) alignment 
Range on Protein: 1006-1132
Range on HMM: 98-230/302.0
GPVSKTVVDFWCLVWQERPPVIVMVTNVKEEGKVKCQQYWPDS--DTKDYGPFSVTL-SDEQVLTEYIIRKI------HLTL-LGSDQPPLMITQYHFTS
 |  .|.  .|.|. | .  ..| .....|... || .|. |   ..  .| ..|.  | .. | |.  .|        ..     .. .  .   .|..
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPEYATSILQFHRRIkNEYKptkGPMLVHCSV
||||| |. | . |.  .   . ||     .|||||.
wpdhGapkeaytaldilkfc.esyk...knvlvhcsa
0051082 (Phosphotyrosine protein) phosphatases II 1132-1225 4.9e-08 28.2 In-house 60-143 (151) alignment 
Range on Protein: 1132-1225
Range on HMM: 60-143/151.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVVSVQ
|.......|. .|   .....| ..|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||.    .
vlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 910-994 5.6e-08 26.5 In-house 6-85 (440) alignment 
Range on Protein: 910-994
Range on HMM: 6-85/440.0
IPVGQFGEFVANGhvKGNEGFKNQFMMLDSGESDHTATVGLtPSNKLLNRFANIVVYDDNRIILRPISGHKDcpNGYINACYVDG
| | .| ..| |   .    |.... .| || |. .   .| |.||. ||. ||..|| .|..|  . |  |  . |||| |..|
iivadfadyvqnn..rrsrafedewsllpsglsqpsdiasl.pnnkvknryrnilaydhsrvmleevkgvpd..sdyinasying
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 958-1030 7.6e-08 26.2 In-house 41-116 (347) alignment 
Range on Protein: 958-1030
Range on HMM: 41-116/347.0
NRFANIVVYDDNRIILRPIS---GHKDCPNGYINACYVDGYSDEYQYIATQGPVSKTVVDFWCLVWQERPPVIVMV
||  .  . |. |..| |     .. | ...|||| ..     . .|| || |. .|| ||| .|   .   .| .
nrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_PTPN1_pd Subfamily PTPN1 1132-1222 8.2e-08 26.3 In-house 164-258 (290) alignment 
Range on Protein: 1132-1222
Range on HMM: 164-258/290.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQR-KRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVV
...|  | |   |  . |.. |  . .. ..   ..     |.|||  .|||  || . | .    | .    .|. .||   | .. | .||  
ilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtad
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1132-1221 2.9e-07 24.9 In-house 139-227 (239) alignment 
Range on Protein: 1132-1221
Range on HMM: 139-227/239.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| |...| |   |  .   ..| .  .. . .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
vyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1132-1221 2.9e-07 24.9 In-house 138-226 (239) alignment 
Range on Protein: 1132-1221
Range on HMM: 138-226/239.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| |...| |   |  .   ..| .  .. . .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
vyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1132-1227 4e-07 24.1 In-house 183-271 (301) alignment 
Range on Protein: 1132-1227
Range on HMM: 183-271/301.0
VTQFQVTNWDSTGEVKNPQTILMIMEeMYrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVvsVQLY
|| .| ..|   |  |    .  .|| .     |. .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||.   |||
vthyqysewtdrgvPkshaelfdlme.lv....kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn..sqly
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1136-1223 4.2e-07 23.7 In-house 194-276 (302) alignment 
Range on Protein: 1136-1223
Range on HMM: 194-276/302.0
QVTNWDSTGEVKNPQTILMIMEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
. . |   |  |...| | |.   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||.   
afsawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1088-1133 4.9e-07 23.4 In-house 91-137 (440) alignment 
Range on Protein: 1088-1133
Range on HMM: 91-137/440.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSVT
. |||. .|||.|||..|  .|.. . ... . |  .||.|||||. 
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsag
0044763 (Phosphotyrosine protein) phosphatases II 1134-1220 5.8e-07 24.8 In-house 77-156 (178) alignment 
Range on Protein: 1134-1220
Range on HMM: 77-156/178.0
QFQVTNWDSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQT
|.. ....  |.   .. .| ..| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..
qylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1132-1220 6e-07 23.9 In-house 135-224 (237) alignment 
Range on Protein: 1132-1220
Range on HMM: 135-224/237.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
. |.| | |   |  ..  ..| .  ..    ..    .  ..|||  |||...|    . . ..| . |.|... ..|   ..|  .||
ihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqt
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1133-1226 7.7e-07 23.2 In-house 171-268 (287) alignment 
Range on Protein: 1133-1226
Range on HMM: 171-268/287.0
TQFQVTNWdsTGEVKNPQ---TILMIMEE--MYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQL
 |... .|    .|  |     | ....       .|.  .   .|||..  .||| .. |  . ... .  | .|| .|.   | .. . ||.|| ..|
kqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrl
0049772 (Phosphotyrosine protein) phosphatases II 1134-1230 7.7e-07 24.6 In-house 182-272 (314) alignment 
Range on Protein: 1134-1230
Range on HMM: 182-272/314.0
QFQVTNWDStGEVKNPQTILMIMEEMYRTqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTeGVIDVFQVLKSQRIQKPGSvQTVVSVQLYLPY
..  ....  |..  .. .. ..| . .    . .. ..|||.. .||.. |..||  . ...   . .... ....|  .|    .. . ..|. .
kylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnp.gfieqleqyefi
subfamily_PTPN14_pd Subfamily PTPN14 1132-1222 4.1e-06 21.0 In-house 185-283 (300) alignment 
Range on Protein: 1132-1222
Range on HMM: 185-283/300.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRG--------NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|  .| |.|   |  ..... |  .||.   .||          .  ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. 
vwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtla
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 954-1115 4.2e-06 20.4 In-house 51-210 (302) alignment 
Range on Protein: 954-1115
Range on HMM: 51-210/302.0
NKLLNRFANIVVYDDNRIILrpisghKDCPNGYINACYVDGYSDEYQYIATQGPVSKTV---VDFWCLVWQERPPVIVMVTNVKEEGKvKCQQYWP--DS
|   |.  .. ..|.|...|      . .|. |.||  |.  . ... | .| |.....    .|| .|.||.   .|..   .|  |   ....|    
nlkknqsedvpildsnlvkl......eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

DTKDYGPFSVTLSDEQVLTEYIiRKIHLTLLGSDQ-PPLMITQYHFTSWPDHGVPEYATSILQFHRRI
| |.|| . |     .   |    .  . .|  .    .... |..| |... ||.  ... .    .
dykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1132-1222 9.1e-06 19.4 In-house 176-266 (439) alignment 
Range on Protein: 1132-1222
Range on HMM: 176-266/439.0
VTQFQVTNWDSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
| ||. . |       .   .|  .  .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||...
vlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalc