Gene PTPRD-25 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP079_AA protein Get Run
AqueP079_AA_813-998 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 896-999 2.4e-55 182.5 In-house 175-278 (290) alignment 
Range on Protein: 896-999
Range on HMM: 175-278/290.0
GAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSINY
||||||||.||||| |||.|.||||||...||||.||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||.....
gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqg

SCYI
 ..|
ifqi
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 895-991 5.7e-54 178.0 In-house 169-265 (287) alignment 
Range on Protein: 895-991
Range on HMM: 169-265/287.0
TGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.|.||.|.|.||||| |||.|..|||||...||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 
agdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtve
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 810-894 9e-43 141.2 In-house 1-85 (290) alignment 
Range on Protein: 810-894
Range on HMM: 1-85/290.0
LVPVGQFGEFVANGHAKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDCPNEYVNACYVD
|.||..||||||||||||||||||||.|||||||.|.||||||||||||||||||||||||||.||||||||||.|||.||||..
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik
0051299 (Phosphotyrosine protein) phosphatases II 809-995 1.1e-35 118.9 In-house 3-277 (288) alignment 
Range on Protein: 809-995
Range on HMM: 3-277/288.0
NLVPVGQFGEFVANGHAKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGhkDCPNEYVNACYV---------------
. ..| .. ..| . .|.|. |....| .| |   |......|   |.  ||. .|. ||..|..|....|  . .. |.|| |.               
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgP

----------------------------------------------------------------------------DTGAKQSVTQFQITNWGSTGEVKN
                                                                             .| .. ||.|. |||   |   .
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

PQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSINY
|. .| ....... ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||.  . .
pellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrf
0050432 (Phosphotyrosine protein) phosphatases II 824-992 1.4e-32 108.6 In-house 37-287 (308) alignment 
Range on Protein: 824-992
Range on HMM: 37-287/308.0
HAKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILrpisghkDCPNEYVNACYVDTG---------------------------
.|... ... .|. | |   ... .|.|   || .||. .|. || .|..|       | .. |.|| |||.                            
kaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

-----------------------------------------------------------------AKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRT
                                                                     ||.|. |||   |   .|. .| ..|.. ..
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

QrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
.   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||.  
l...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq
0045450 (Phosphotyrosine protein) phosphatases II 811-995 7.9e-32 106.6 In-house 9-295 (307) alignment 
Range on Protein: 811-995
Range on HMM: 9-295/307.0
VPVGQFGEFVANGHAKGNEGFRNQFMMLDSGES--DHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHkDCPNEYVNACYV---------------
... ..  .|.  ......|.. .| .| | .    .. ...|   || .||. .|. ||..|..| ...|. . .. |.|| ||               
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkr

----------------------------------------------------------------------------------DTGAKQSVTQFQITNWGS
                                                                                   ||    ||.|. |.|  
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpd

TGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVVSINY
.|  ......| ..||. . ...  ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||.   . .
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrf
0046845 (Phosphotyrosine protein) phosphatases II 831-996 2.3e-31 104.7 In-house 2-266 (284) alignment 
Range on Protein: 831-996
Range on HMM: 2-266/284.0
FRNQFMMLDSGESDH--SVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHkDCPNEYVNACYVD----------------------------------
.. .|..| |   ..  |..|.|   |. .||. .|..||..|..|....|. .  ..|.|| |||                                  
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

------------------------------------------------------------TGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRK
                                                            ||    ||.|..|.|   |   .|. .| ..... . ...
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVVSINYS
  |.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||.  . . 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv
0040438 (Phosphotyrosine protein) phosphatases II 815-998 2.6e-31 104.5 In-house 4-270 (317) alignment 
Range on Protein: 815-998
Range on HMM: 4-270/317.0
QFGEFVANGHAKGNEGFRNQFMMLDSGESDhSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGhkDCPNEYVNACYVD--------------------
.. ...   ..... .....|..|.|   | . .|..   || .||. .|. ||..|..| |..|  | .. |.|| |||                    
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntve

-------------------------------------------------------------------TGAKQSVTQFQITNWGSTGEVKNPQTILMIMEE
                                                                   .. .  ||.|. |.|   |  ..|...| ..|.
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

MYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSINYSCY
. . .. .... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.|||   . . ..
vreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyd
0047943 (Phosphotyrosine protein) phosphatases II 824-997 2.8e-31 104.4 In-house 7-265 (273) alignment 
Range on Protein: 824-997
Range on HMM: 7-265/273.0
HAKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILrpisghKDCPNEYVNACYVDT----------------------------
...|. ... .| .| |   ... .|.|   || .||. .|. ||..|..|      .| .. |.|| |||.                            
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

--------------------------------------------------------------GAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQR
                                                              | .  ||.|. |.|   |   ... .| ..|.. ....
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

KR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSINYSC
.  .|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||.  . . .
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0036941 (Phosphotyrosine protein) phosphatases II 825-991 4.6e-31 103.6 In-house 9-264 (297) alignment 
Range on Protein: 825-991
Range on HMM: 9-264/297.0
AKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILrpisghKDCPNEYVNACYVD------------------------------
.... ... .|. |..   . | .|.|   |. .||. .|. ||..|..|      .| .. |.||.|||                              
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

-------------------------------------------------------------TGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQR
                                                             .| .  ||.|..|.|   |   .|...| ..|.. . ..
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

KR-GNTSIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVV
.  ... ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||. 
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 810-895 6.6e-31 102.3 In-house 1-81 (287) alignment 
Range on Protein: 810-895
Range on HMM: 1-81/287.0
LVPVGQFGEFVANGHAKGNEGFRNQFMMLDS-GESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRpisghkDCPNEYVNACYVDT
|.||..||||||.|||||||||.|||..|.. ......||....|.|| .||...|.|.|..|..|.      .. ..|.||...|.
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidg
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 899-991 6.9e-31 102.1 In-house 188-280 (301) alignment 
Range on Protein: 899-991
Range on HMM: 188-280/301.0
QSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
..|.|.|.|.|   | |..|.|.|......  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.|  
wdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLe
0039614 (Phosphotyrosine protein) phosphatases II 818-998 2.7e-29 98.0 In-house 21-283 (297) alignment 
Range on Protein: 818-998
Range on HMM: 21-283/297.0
EFVANGHAKGNEGFRNQFMMLDSGESDhsVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHkDCPNEYVNACYVDTGAK-------------------
 ..   .|... .....|..| |   |   ...|   || .||. .|. ||..|..| |. |. | .. |.|| |||.  .                   
lllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedF

-----------------------------------------------------------------QSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQR
                                                                   ||.|| |.|   |   .....| ..|.. . ..
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

KR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSINYSCY
.  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.|||   . . ..
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyd
0043336 (Phosphotyrosine protein) phosphatases II 812-997 2.6e-28 94.7 In-house 3-270 (278) alignment 
Range on Protein: 812-997
Range on HMM: 3-270/278.0
PVGQFGEFVANGHAKGNEGFRNQFMMLDSGESdHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDcpNEYVNACYV------------------
.| .. ..... ..... .....|  |.|     . ...|   || .||. .|. || .|..| ...|. |  . |.|| ||                  
svkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpe

--------------------------------------------------------------------DTGAKQSVTQFQITNWGSTGEVKNPQTILMIM
                                                                     .| .. ||... ..|   |   .....| ..
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

EEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSINYSC
... . ..   |. ..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.|||   . . .
kavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfly
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 898-990 1.3e-26 88.5 In-house 177-269 (305) alignment 
Range on Protein: 898-990
Range on HMM: 177-269/305.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
...|.|.|.|.|   | .. . ..| ..... ..|.|  .....||||..|||. .|.|    ....|.|.|.|||.|||  | .... ||| 
srtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl
0042113 (Phosphotyrosine protein) phosphatases II 851-993 1.4e-25 85.5 In-house 5-232 (245) alignment 
Range on Protein: 851-993
Range on HMM: 5-232/245.0
LTSSNKLLNRFANIVVYDDNRIILRPISGHKDCPneYVNACYV---------------------------------------------------------
|   || .||. .|. ||..|..| |..|. |..  |.||.||                                                         
llpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

------------------------------DTGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINK
                               .. .. |.... ..|   |.  .....| ..|.. . ... .|. ..||||. |||...|.|| . .. 
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

CKTEGVIDVFQVLKSQRIQKPGSVQTVVSI
 ..|. .......|  | |.||.|||   .
lekelgvsleeavkelrsqRpgavqtpsqy
0045098 (Phosphotyrosine protein) phosphatases II 840-994 3.7e-24 81.0 In-house 18-262 (278) alignment 
Range on Protein: 840-994
Range on HMM: 18-262/278.0
SGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIIlrpisghkdcpnEYVNACYV----------------------------------------------
.  .  ..|..|  .|. .||. .|. || .|..            .|.|| |.                                              
llgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

-------------------------------------------DTGAKQSVTQFQITNWGSTGEVKNP--QTILMIMEEMYRTQR------------KRG
                                            .. .  ||......|   |   .|  . .| ..|.. . ..              .
caqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

NTSIVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVVSIN
.. ..||||  |||.....|| . .  .  ||..|.....|  | |.|| .||.   ..
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 813-991 1.1e-23 78.2 In-house 8-181 (440) alignment 
Range on Protein: 813-991
Range on HMM: 8-181/440.0
VGQFGEFVANGhaKGNEGFRNQFMMLDSGESDHSVTVGLTsSNKLLNRFANIVVYDDNRIILRPISGHKDcpNEYVNACYVDTGAKQSVTQFQITNWGST
| .| ..| |   .    | ... .| || |. |   .|  .||. ||. ||..|| .|..|  . |  |  ..|.|| |..    ... |..   |   
vadfadyvqnn..rrsrafedewsllpsglsqpsdiaslp.nnkvknryrnilaydhsrvmleevkgvpd..sdyinasyingiesrtlkqyhyqgwpdk

GEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|  |    .| .....  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  |||  
gvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe
0040439 (Phosphotyrosine protein) phosphatases II 847-991 2.3e-23 78.5 In-house 3-233 (249) alignment 
Range on Protein: 847-991
Range on HMM: 3-233/249.0
VTVGLTSSNKLLNRFANIVVYDDNRIILRPISGhkDCPNEYVNACYVD----------------------------------------------------
..|.|   || .||. .|. || .|..| ...|    .. |.|| |.|                                                    
ysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

-----------------------------------TGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAA
                                   .| .  |...|.|.|  .|  ......| ..|..   ...   .. ..||||. |||...|.|| 
plggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
. ..  ..|. .|.....|  | |.||.||.  
lmleqlekelgvdleeavkllrsqRpgavqnpe
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 897-991 6.3e-23 76.5 In-house 183-277 (298) alignment 
Range on Protein: 897-991
Range on HMM: 183-277/298.0
AKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 ...| |.. |.| . |. .| ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.|||  
kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqtee
subfamily_PTPRD_pd Subfamily PTPRD 898-989 3.7e-21 70.4 In-house 176-266 (564) alignment 
Range on Protein: 898-989
Range on HMM: 176-266/564.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. |.||. |.| ..|  ......| ..... ... ....  ||||||  |||. .|..    ... |.|...|..|..|  | |..  |||
sreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 901-990 6.1e-21 69.5 In-house 164-252 (283) alignment 
Range on Protein: 901-990
Range on HMM: 164-252/283.0
VTQFQITNWGSTGEVKnPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. .|. .| . ||   .   |. .. .   |..  .. |||||| ..||.|.|.||...... .|| |.|||.|.|  | |... ||| 
lahyqvidWleygeqa.iinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl
Y_phosphatase Protein-tyrosine phosphatase 898-990 7.9e-21 69.9 Pfam-A 132-223 (235) alignment 
Range on Protein: 898-990
Range on HMM: 132-223/235.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|..|.|...|||   |  ..|. .| ..... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
krevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
Y_phosphatase Protein-tyrosine phosphatase 898-990 7.9e-21 69.9 In-house 132-223 (235) alignment 
Range on Protein: 898-990
Range on HMM: 132-223/235.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|..|.|...|||   |  ..|. .| ..... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
krevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 898-989 2.4e-20 67.9 In-house 174-265 (318) alignment 
Range on Protein: 898-989
Range on HMM: 174-265/318.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. | |...|.|  .|  ... ..| .. .  ..|.| |.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  |||
srqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 898-991 3.3e-20 67.4 In-house 136-229 (250) alignment 
Range on Protein: 898-991
Range on HMM: 136-229/250.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.. | |.. ..|   |  .. ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |.| |.|||.|.|  |...|..|..  
erivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 899-990 2e-19 64.8 In-house 178-269 (319) alignment 
Range on Protein: 899-990
Range on HMM: 178-269/319.0
QSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .|..|| |.|   .  .. ...| ..... ....|  .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||. 
RevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrp
subfamily_PTPRA_pd Subfamily PTPRA 898-994 4.8e-19 63.4 In-house 190-285 (330) alignment 
Range on Protein: 898-994
Range on HMM: 190-285/330.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSIN
.. |.||  | |   |   .|. .| ..... ..... .. .||||||  |||.  |..  . ... |.|...|||...|. | |.|  |||    .
srlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqye
0037934 (Phosphotyrosine protein) phosphatases II 849-993 8.4e-19 63.5 In-house 4-231 (243) alignment 
Range on Protein: 849-993
Range on HMM: 4-231/243.0
VGLTSSNKLLNRFANIVVYDDNRIILrpisghKDcpNEYVNACYVD------------------------------------------------------
..|   |.  ||. .|. ||..|..|      ..  . |.|| ...                                                      
iallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

---------------------------------TGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMF
                                 .. .. |.... ..|   |   .|. .| ...|..  ...        ..  ..||||  |||....
gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

CAAATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTVVSI
.|| . . ..   | .|.....|  | |.|| .|||   .
iaaylmllll...g.vdleeavkllreqRpgkavqtpsqy
DSPc_SM00195 898-990 1.8e-18 62.2 In-house 157-248 (263) alignment 
Range on Protein: 898-990
Range on HMM: 157-248/263.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
...|||.|..||   |  .... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
trkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
PTPc_SM00194 898-990 1.8e-18 62.2 In-house 157-248 (263) alignment 
Range on Protein: 898-990
Range on HMM: 157-248/263.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
...|||.|..||   |  .... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
trkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
PTPc_DSPc_SM00012 901-994 2.5e-18 61.6 In-house 2-97 (105) alignment 
Range on Protein: 901-994
Range on HMM: 2-97/105.0
VTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVSIN
|.....|.|  .|  .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.|||     
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqyl
I-set Immunoglobulin I-set domain 703-789 1.2e-15 49.1 Pfam-A 1-90 (90) alignment 
Range on Protein: 703-789
Range on HMM: 1-90/90.0
PVIEEFPNDVTSEEGCQVHFKVKFKGTPTPFFNWYHNGEPVTDDYAHELRGDG---SLLLVSVEEKHKGTYRFVANNEAGTVSQQVVLTV
|.... ..||. .|| .| .... .|.|.| ..|...|.... .  .... ..   .| . .||.. .|.|. .|.|.||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Ptp69D_pd Subfamily Ptp69D 896-989 2.5e-15 51.4 In-house 179-271 (307) alignment 
Range on Protein: 896-989
Range on HMM: 179-271/307.0
GAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 ... |.|.. |.|  .   . ....| ..|...  ...  .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  || 
edsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs
subfamily_PTPRK_pd Subfamily PTPRK 898-990 3.3e-15 50.7 In-house 172-263 (314) alignment 
Range on Protein: 898-990
Range on HMM: 172-263/314.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. | ||| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||. .|.| .. ..  ..|||.|||.. |. | .|.  |.| 
irevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvete
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 898-995 3.7e-15 51.0 In-house 184-282 (319) alignment 
Range on Protein: 898-995
Range on HMM: 184-282/319.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSINY
....||| .  |   |  . |  ......   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|   .
irkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 898-990 4e-15 50.5 In-house 172-263 (315) alignment 
Range on Protein: 898-990
Range on HMM: 172-263/315.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. ||||| |.|   |  |.  ..| .. |.    ... . |..||||  |||. .....   ... | . ..|||...|  | ..|  ||| 
srtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqte
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 898-995 4.2e-15 51.0 In-house 148-246 (284) alignment 
Range on Protein: 898-995
Range on HMM: 148-246/284.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSINY
.....|| .  |   |  . |  ......   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|   .
irkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 899-990 5.6e-15 49.4 In-house 172-262 (515) alignment 
Range on Protein: 899-990
Range on HMM: 172-262/515.0
QSVTQFQITNWGSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. ||||. |.|   |  |. ...| .. |. .... . . ....|||  |||  .....   . . ||  ..|||....  | ..|  ||| 
rtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 921-991 5.9e-15 50.0 In-house 176-246 (267) alignment 
Range on Protein: 921-991
Range on HMM: 176-246/267.0
ILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.  ..  . . | . ||  .||.||| ||||  |  . . ... ||||| |.|. |.  | |..| |.|  
lkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtke
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 894-990 1.2e-14 49.2 In-house 173-274 (325) alignment 
Range on Protein: 894-990
Range on HMM: 173-274/325.0
DTGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYR---TQ--RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQ
. |  .|| |||.  |   |  | | |.. |.. .     .     .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.
kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmve

TV
||
tv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 896-995 1.3e-14 49.0 In-house 167-267 (281) alignment 
Range on Protein: 896-995
Range on HMM: 167-267/281.0
GAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVSIN
| ...|.|.. |.|  .|  .... .|   .|......|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||||  .
getreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqye

Y
.
f
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 897-990 3.1e-14 47.8 In-house 175-270 (297) alignment 
Range on Protein: 897-990
Range on HMM: 175-270/297.0
AKQSVTQFQITNWGSTGEVK--NPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.. | |.| ..| .  . .  . ...| ...|.  .  .. .. ..|||.  ||| .....    . . | |  .|.|...|  | ..|  ||| 
arrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 826-896 4.1e-14 47.0 In-house 12-81 (301) alignment 
Range on Protein: 826-896
Range on HMM: 12-81/301.0
KGNEGFRNQFMMLDSGEsDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDCPNEYVNACYVDTG
| ...| .|.  |..|| |.| ||||...|| |||| ||.|||||||||.| .  . | .||.|| |.|  
khsnkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgy
0036282 (Phosphotyrosine protein) phosphatases II 895-989 5.3e-14 47.8 In-house 63-155 (174) alignment 
Range on Protein: 895-989
Range on HMM: 63-155/174.0
TGAKQSVTQFQITNWGSTGEVKNPQtILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQT
.  .... |.. ..|   |.   .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
subfamily_PTPN23_pd Subfamily PTPN23 896-996 5.5e-14 46.7 In-house 168-272 (288) alignment 
Range on Protein: 896-996
Range on HMM: 168-272/288.0
GAKQSVTQFQITNWGSTGEVKNPQTILMIMEEM---YRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVV
 |..||.  |.|.| . |  . |.|.| ...|.   |...... .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||.. 
davksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqeke

SINYS
 .. |
qlkfs
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 899-991 5.5e-14 46.8 In-house 175-266 (315) alignment 
Range on Protein: 899-991
Range on HMM: 175-266/315.0
QSVTQFQITNWGsTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
. | |...| |  . .| .  . || .    .  ..   ..||||||. |||.  |..  . ... ..| .|||.....  | .. . ||.. 
revvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvae
subfamily_PTPN12_pd Subfamily PTPN12 896-989 6e-14 46.6 In-house 167-262 (290) alignment 
Range on Protein: 896-989
Range on HMM: 167-262/290.0
GAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQT
.....|.||. |.|   |  ......| ..|.. |. ... .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  |||
kesrkvyqfhYtaWPDhgvPssaksllelielv.relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqt
subfamily_PTPRD_pd Subfamily PTPRD 810-895 7e-14 46.4 In-house 4-86 (564) alignment 
Range on Protein: 810-895
Range on HMM: 4-86/564.0
LVPVGQFGEFVANGHAKGNEGFRNQFMMLDSGeSDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDCpnEYVNACYVDT
 .|| .. |.||. .|...  | ...  ...| . .....   . ||  ||.|||| || .|..|... |....  .|.|| ..|.
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegs..DYINAsfidg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 897-993 7e-14 46.5 In-house 173-268 (288) alignment 
Range on Protein: 897-993
Range on HMM: 173-268/288.0
AKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSI
 .  .||.| . |  .|  .. . .| ... .  .. .     |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||.   
teleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqY
subfamily_PTPRB_pd Subfamily PTPRB 897-991 9.8e-14 46.1 In-house 177-272 (293) alignment 
Range on Protein: 897-991
Range on HMM: 177-272/293.0
AKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQ-RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
....|.|.. | |   |  ....|.| ..... ... ..  .. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||. 
eerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtek
fn3 Fibronectin type III domain 400-471 1.3e-13 44.0 Pfam-A 11-84 (85) alignment 
Range on Protein: 400-471
Range on HMM: 11-84/85.0
KNPDAINIVWNPPTIPNGIIAVYEIRYRESTSTG-PYNITNTTNT-YYSIVGLIPNTSYTIGVRAYTSIGPGEW
 ... ... |.||. ..| |  ||..|||..... . ..|.. .|  . . || |.|.|.. |.|..  | |..
vtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 898-990 1.8e-13 45.2 In-house 160-254 (274) alignment 
Range on Protein: 898-990
Range on HMM: 160-254/274.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
..||. .  |.|  .   ....|.| ...|. ...... .   ..|||||  .||  .| |.  .... . |.|.||...    |... | ||| 
ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts
fn3 Fibronectin type III domain 297-377 3.5e-13 42.7 Pfam-A 5-83 (85) alignment 
Range on Protein: 297-377
Range on HMM: 5-83/85.0
DIIFSSVESVSMTVSWDEVPcnGRNGPITGYYLTYTNITSNTSCIVNITGGDNRMYNLTGLIPYTNYTVSIIPYNYNMNGP
.. .|.| | |.|.||.. .   ..|||||| ..| . ...  .    . .. . ..|||| |.|.|....  .| . .||
nlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_PTPRG_pd Subfamily PTPRG 898-990 4.3e-13 43.3 In-house 182-273 (563) alignment 
Range on Protein: 898-990
Range on HMM: 182-273/563.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. |.|.. |.|  .|  . .   |. ..   .....     ||||||  |||. ....  | ... ..| ...||..||  | |..  ||| 
eklvrqyhytkWPdhgvPehslpvLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqte
0041856 (Phosphotyrosine protein) phosphatases II 855-995 9.2e-13 43.6 In-house 1-162 (182) alignment 
Range on Protein: 855-995
Range on HMM: 1-162/182.0
NKLLNRFANIVVYDDNRiilrpisghkdcPNEYVNACYVDTGAKQ--------------------------------------------SVTQFQITNWG
|. .||. .|. || .|            .. |.|| ... . ..                                             ..|.. ..| 
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwp

STGEVKnPQTILMIMEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDVFQVLKSQRIQKPGSVQTVVSINY
  |    ....| ..||...      .  ..||||  |||.....||   . .    | .......|  | ..||.|.|   . .
Dhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyff
subfamily_CG7180_pd Subfamily CG7180 900-994 1e-12 42.3 In-house 181-280 (296) alignment 
Range on Protein: 900-994
Range on HMM: 181-280/296.0
SVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRG-----NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSIN
 |..||.| | .  .|    . |. . .. |. |..      .  .||..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..|    
ivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYk
subfamily_PTPRG_pd Subfamily PTPRG 811-895 1.2e-12 41.8 In-house 1-86 (563) alignment 
Range on Protein: 811-895
Range on HMM: 1-86/563.0
VPVGQFGEFVANGHAKGNEGFRNQFMMLDSGESDH--SVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDCPnEYVNACYVDT
||| .| . ||. ||.|. || ..|  | |   ..   ..     .||  ||  ||| ||  |. |.|..|.|.   .|.|| |.| 
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidG
0043147 (Phosphotyrosine protein) phosphatases II 891-993 2.3e-12 42.5 In-house 55-150 (172) alignment 
Range on Protein: 891-993
Range on HMM: 55-150/172.0
CYVDTGAKQSVTQFQITNWGSTGEVkNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQT
.|  .. .... |.. ..|   |   ... .| ..| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||.
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqn

VVSI
   .
psqy
subfamily_PTPN6_pd Subfamily PTPN6 897-992 1.1e-11 39.3 In-house 184-285 (306) alignment 
Range on Protein: 897-992
Range on HMM: 184-285/306.0
AKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
 ...| |.. ..|   |  |.|...|  .|.. | |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | ||| 
eerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqte

VS
  
qq
subfamily_PTPN13_pd Subfamily PTPN13 894-990 1.2e-11 39.5 In-house 161-255 (273) alignment 
Range on Protein: 894-990
Range on HMM: 161-255/273.0
DTGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
..|. . |.... ..|   |  .... .| .. |. | |.   .. ||||||  .||| .. .  . ..  . .  .|| ..... | |. | ||| 
esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 811-895 3.9e-11 37.6 In-house 5-86 (319) alignment 
Range on Protein: 811-895
Range on HMM: 5-86/319.0
VPVGQFGEFVANGHAKGNEGFRNQFMMLDSGESDhSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDcpNEYVNACYVDT
..| .. | . . ...|. .....|..|. ...| ...   .  ||  ||. ||. ||  |..| .. | ..   .|.|| ..|.
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgveg..sdyinasfidg
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 895-995 4.2e-11 37.3 In-house 148-255 (270) alignment 
Range on Protein: 895-995
Range on HMM: 148-255/270.0
TGAKQSVTQFQITNWGSTGEVKNP------QTILMIMEEMYRTQRKRGN-TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSV
.| .. .. |. ..|   | ....      . .| ..... |....  . . ..||||. |||. .. |  ....  .... .|| ....  | ...  |
kgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalv

QTVVSINY
|... ...
qhpeqyef
subfamily_Ptp69D_pd Subfamily Ptp69D 818-894 4.9e-11 37.3 In-house 11-85 (307) alignment 
Range on Protein: 818-894
Range on HMM: 11-85/307.0
EFVANGHAKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDCpnEYVNACYVD
| . . . . ..|. . . .| . |.|.| .|.    |.| ||. .|. .|..|..|..| |..|   .|.|| .. 
ealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkeds..dYinasfik
0048076 (Phosphotyrosine protein) phosphatases II 888-991 5.5e-11 37.8 In-house 34-130 (145) alignment 
Range on Protein: 888-991
Range on HMM: 34-130/145.0
VNACYVDTGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVLKSQRIQKPGSV
.| ..  .. .. ..|.. ..|   |.   ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......|.  | | ||.|
lnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgav

QTVV
... 
pnpg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 819-899 1.3e-10 35.8 In-house 11-89 (288) alignment 
Range on Protein: 819-899
Range on HMM: 11-89/288.0
FVANGHAKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDcpNEYVNACYVDTGAKQ
 ||. .|....|| ...  | . |...|||.|  . |.  ||. ||. || .|. |.     ..  ..|.|| |.|   |.
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeag..aDYinasyidgekkk
0051429 (Phosphotyrosine protein) phosphatases II 876-991 1.7e-10 36.6 In-house 76-212 (272) alignment 
Range on Protein: 876-991
Range on HMM: 76-212/272.0
PISGHKDCPNEYVN---------------------ACYVDTGAKQSVTQFQITNWGSTGEVKNPqtILMIMEEMYRtqrkrgNTSIVVHCSDTVGRSAMF
|| .. . . .| .                       ....|.   |.... |.|   |  ...  .| ..|.. .      .  ..||||  ..|....
pilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtv

CAAATTINKCKTEGVID--------VFQVLKSQRIQKPGSVQTVV
.|.   .     | ..|        ......  | | ||.|||  
vallllllgvsletivddYlltnlyleeaveelraqrpgavqtee
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 811-897 1.8e-10 35.4 In-house 2-86 (318) alignment 
Range on Protein: 811-897
Range on HMM: 2-86/318.0
VPVGQFGEFVANGHAKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDcpNEYVNACYVDTGA
..| .. . |.. ...|.  . ... .|.  |.  . .  |.. ||  ||.|||. ||. |. |....|...   .|.|| |.|   
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeeg..sDyinanyidGyr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 811-895 2.1e-10 35.2 In-house 4-84 (305) alignment 
Range on Protein: 811-895
Range on HMM: 4-84/305.0
VPVGQFGEFVANGHAKGNEGFRNQFMMLDSGesDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKdcPNEYVNACYVDT
. . .. ... . ... ..|. .|. .| .   ..|. || .. ||  ||...|...||.||||.. . ..   ..|.||.|||.
ialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdg
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 897-990 4.3e-10 33.5 In-house 276-371 (392) alignment 
Range on Protein: 897-990
Range on HMM: 276-371/392.0
AKQSVTQFQITNWGSTGEVKNP--QTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|  .|||.|.  |   |  ...  ...| ..  .  .  .. . ||.|||    ||. .||.|   | .      .|.|| .|  | ..  .||| 
ashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqte
subfamily_PTPN3_pd Subfamily PTPN3 897-997 4.6e-10 33.9 In-house 169-268 (280) alignment 
Range on Protein: 897-997
Range on HMM: 169-268/280.0
AKQSVTQFQITNWGSTGEVKNPQTILMIMEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSINYS
 .....|.| ..|   |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  |.. .  ..  . . ....  | |.   |||.   .. 
eerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfv

C
|
C
0049260 (Phosphotyrosine protein) phosphatases II 888-994 4.9e-10 34.8 In-house 55-140 (152) alignment 
Range on Protein: 888-994
Range on HMM: 55-140/152.0
VnacyvdtgakqsvtQFQITNWGSTGEVKNPQTILMIMEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSV
               |.. ..|   |  ...| .|.... . .  ... .  ..||||  |||.....||   .        ........  | ..||.|
i..............qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgav

QTVVSIN
..   . 
pnpgqlr
subfamily_PTPRN_pd Subfamily PTPRN 895-992 4.9e-10 33.6 In-house 183-280 (297) alignment 
Range on Protein: 895-992
Range on HMM: 183-280/297.0
TGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGnTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVS
|   ..||||    | ..|   .....|     . .. | |  ..||||||| .||. ....    .|.  |    ||.   |.  | |.|| |.|   
tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdq
subfamily_PTPRB_pd Subfamily PTPRB 811-894 7.1e-10 33.4 In-house 7-88 (293) alignment 
Range on Protein: 811-894
Range on HMM: 7-88/293.0
VPVGQFGEFVANGHAKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDcpNEYVNACYVD
. . .| |.|.. .|. . .| ... .| . ..|..|..  .. |.  ||. ||. || .|. | .......  ..|.|| |..
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesg..sDYinanyip
subfamily_PTPN9_pd Subfamily PTPN9 897-992 7.9e-10 33.2 In-house 171-278 (297) alignment 
Range on Protein: 897-992
Range on HMM: 171-278/297.0
AKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQR---------KRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKP
 ...|| ||.. |   |  .. ...| ..|.. ..|          ..|   .  ||||||  .||.  |..   .... ...|..||....|  | |. 
esrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqra

GSVQTVVS
 |.||   
fsiqtpeq
0048179 (Phosphotyrosine protein) phosphatases II 895-991 9.3e-10 33.9 In-house 48-132 (144) alignment 
Range on Protein: 895-991
Range on HMM: 48-132/144.0
TgakqsVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVV
.     ..|.. ..|   |    .. .| ..| . . ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|..  
e.....giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 819-896 1.7e-09 32.3 In-house 17-95 (298) alignment 
Range on Protein: 819-896
Range on HMM: 17-95/298.0
FVANGHAKGNEGFRNQFMMLDSGES---DHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDCpnEYVNACYVDTG
..|  ..|.  |. ..|  |.|..|   ... .|. ...||  ||.|.|. .|  |..|. ... ...  .|.|| .... 
laavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadees..dYiNAsflhay
0049772 (Phosphotyrosine protein) phosphatases II 843-987 1.8e-09 33.3 In-house 34-263 (314) alignment 
Range on Protein: 843-987
Range on HMM: 34-263/314.0
SDHSVTVGLTSSNKLLNRFANIVVYDdNRIILrPISGHKDCPneYVNACYV-------------------------------------------------
......|.    |.  ||. .|. .| || || |  .....   | || ||                                                 
peltilvadlflnrdknryldilpad.nrvil.pglpvsgsd..yinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

-------------------------------------------DTGAKQSVTQFQITNWGStGEVKNPQTILMIMEEMYRTqrkRGNTSIVVHCSDTVGR
                                           .   .. . ..  ...   |..  .. .. ..| . .    . .. ..|||.. .||
evladelsrLdaAlgKtpllildgngneptaadlellkeelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgR

SAMFCAAATTINKCKTeGVIDVFQVLKSQRIQKP--GSV
.. |..||  . ...   . .... ....|  .|  |..
tgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfi
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 824-895 2.2e-09 31.8 In-house 10-79 (281) alignment 
Range on Protein: 824-895
Range on HMM: 10-79/281.0
HAKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKdcPNEYVNACYVDT
... |.|| ...  | . . |.. |   .  |.| ||. ||| ||  |. . | . .|   ..|.|| .|..
sqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvpg
subfamily_PTPN1_pd Subfamily PTPN1 895-996 2.7e-09 31.1 In-house 158-263 (290) alignment 
Range on Protein: 895-996
Range on HMM: 158-263/290.0
TGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQR-KRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTV
|   .....|  | |   |  . |.. |  . .. ..   ..     |.|||  .|||  || . | .    | .    .|. .||   | .. | .|| 
tqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta

VSINYS
  ...|
dqlrfs
subfamily_PTPRA_pd Subfamily PTPRA 809-895 3e-09 31.2 In-house 12-96 (330) alignment 
Range on Protein: 809-895
Range on HMM: 12-96/330.0
NLVPVGQFGEFVANGHAKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDcpNEYVNACYVDT
  .|| .. | .    |  |. ||..|  | .|. . .. .     ||  ||. ||. || .|.|| ...|...   .|.|| ..| 
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvee..sdyinasfidG
0046846 (Phosphotyrosine protein) phosphatases II 899-991 5.8e-09 31.4 In-house 74-160 (176) alignment 
Range on Protein: 899-991
Range on HMM: 74-160/176.0
QSVTQFQITNWGSTGEVKNpQTILMIMEEMYRTQRKRgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTVV
.   |.. ..|   |     . .| ..|.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.|||  
klgiqylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 813-899 8.5e-09 29.5 In-house 7-87 (95) alignment 
Range on Protein: 813-899
Range on HMM: 7-87/95.0
VGQFGEFVANGHAKGNEGFRNQFMMLDSgESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILrpiSGHKDcpNEYVNACYVDTGAKQ
|  |   | . |.. .. | |.|  .    |  . ||| . .|   ||| ||. ||  |..|   . ..|   .|.|||.||  |..
vsvfhshvlemhsnsdqefdnefksism.tsgapytvgsseanipknrflnifpydatrvvl...ttkrd..sdyinacfvdgyark
0051082 (Phosphotyrosine protein) phosphatases II 899-991 1.4e-08 30.0 In-house 58-140 (151) alignment 
Range on Protein: 899-991
Range on HMM: 58-140/151.0
QSVTQFQITNWGSTGEVKNPQTILMIMEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVV
  |....|..|  .|   .....| ..|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||.  
ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 889-995 1.5e-08 28.4 In-house 179-279 (302) alignment 
Range on Protein: 889-995
Range on HMM: 179-279/302.0
NACYVDtGAKQSVTQFQITNWGSTGEVKNPQTILMIMEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQ
|    .   |..|  .. . |   |  |...| | |.   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||
nekkkk.kvkktvdilafsawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavq

TVVSINY
.   . |
deqqliy
DSPc_SM00195 831-896 3.7e-08 28.4 In-house 2-65 (263) alignment 
Range on Protein: 831-896
Range on HMM: 2-65/263.0
FRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHkdCPNEYVNACYVDTG
....|  |.. .|....| .  ..||  ||. ||..||..|..| .. ..   ...|.|| |... 
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikga
PTPc_SM00194 831-896 3.7e-08 28.4 In-house 2-65 (263) alignment 
Range on Protein: 831-896
Range on HMM: 2-65/263.0
FRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHkdCPNEYVNACYVDTG
....|  |.. .|....| .  ..||  ||. ||..||..|..| .. ..   ...|.|| |... 
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikga
subfamily_PTPN14_pd Subfamily PTPN14 892-991 5.8e-08 27.1 In-house 176-283 (300) alignment 
Range on Protein: 892-991
Range on HMM: 176-283/300.0
YVDTGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNT--------SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQK
.. .. ...|  .| |.|   |  ..... |  .||.   .||  ..         ..||||. |||. .   .   |.  ... .||. .||.  | |.
hlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqr

PGSVQTVV
   |||. 
mllvqtla
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 898-990 6e-08 27.1 In-house 135-226 (239) alignment 
Range on Protein: 898-990
Range on HMM: 135-226/239.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. | |...| |   |  .   ..| .  .. . .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
eryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 898-990 6.1e-08 27.1 In-house 136-227 (239) alignment 
Range on Protein: 898-990
Range on HMM: 136-227/239.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. | |...| |   |  .   ..| .  .. . .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
eryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_PTPN6_pd Subfamily PTPN6 822-899 6.2e-08 27.0 In-house 19-95 (306) alignment 
Range on Protein: 822-899
Range on HMM: 19-95/306.0
NGHAKGNEGFRNQFMMLDSGESD--HSVTVGLTSSNKLLNRFANIVVYDDNRIILRpisGHKDCPNEYVNACYVDTGAKQ
... ....|| ..|  |.  |.   .| . |   .||  ||. ||. .|..|.||.    ..   ..|.|| |... .|.
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkg
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 815-898 8.7e-08 26.6 In-house 9-89 (325) alignment 
Range on Protein: 815-898
Range on HMM: 9-89/325.0
QFGEFVANGHAKGNEGFRNQFMMLDSGESdHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPIsgHKDCPNEYVNACYVDTGAK
.. |.| . .|. ..|| ..| .| | ..  . .|     ||  ||| |.| .| .|..|     ..|   .|.|| |. .  |
nlvehvekkkaqdqdgfahefgllpsddg.iakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 811-895 8.8e-08 26.4 In-house 6-87 (315) alignment 
Range on Protein: 811-895
Range on HMM: 6-87/315.0
VPVGQFGEFVANGHAKGNEGFRNQFMMLDSGEsDHSVTVGLTSSNKLLNRFANIVVYDDNRIILrPISgHKDCPNEYVNACYVDT
.|. |.  .||. .|  ..||....  .  |.  | . |   . ||  ||. ||. ||  |. | |.   .|   .|||| ..| 
ipldqlityvaqkkastkngfkqdyesipggq.lhpldvakkienkqknryiniiaydksrvql.pll.endphsdyvnanfidG
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 897-997 9.5e-08 26.2 In-house 166-270 (287) alignment 
Range on Protein: 897-997
Range on HMM: 166-270/287.0
AKQSVTQFQITNWgsTGEVKNPQ---TILMIMEE--MYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  . | |... .|    .|  |     | ....       .|.  .   .|||..  .||| .. |  . ... .  | .|| .|.   | .. . ||.|
earvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

VSINYSC
| . ...
vqlrlly
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 898-992 1.3e-07 25.7 In-house 180-269 (301) alignment 
Range on Protein: 898-992
Range on HMM: 180-269/301.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEeMYrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
 ..|| .| ..|   |  |    .  .|| .     |. .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||.  
trtvthyqysewtdrgvPkshaelfdlme.lv....kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq
fn3 Fibronectin type III domain 106-178 2.2e-07 24.1 Pfam-A 2-77 (85) alignment 
Range on Protein: 106-178
Range on HMM: 2-77/85.0
TPTDLNATRLstDLSRVRLSWSTV----SGATGYEVYYQLSSSTPVSAGTTAFKST-SMDVSGLFRGSTYTFYVVSYG
 |..|...      . ..||||      .  ||||| |. .... ..   |. ..| |. ..||  |..|.| | .. 
aPenlsvsev..tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavn
Ig_3 Immunoglobulin domain 702-776 2.7e-07 22.7 Pfam-A 2-75 (75) alignment 
Range on Protein: 702-776
Range on HMM: 2-75/75.0
PPVIEEFPNDVTSEEGcqVHFKVKFKGTP-TPFFNWYhNGEPVTDDYAHELRGDGSLLLVS-VEEKHKGTYRFVANN
| .. .....|||...  | .    .|.| .|.. || ...|  ..  . ... .| | .| | ... |||. ||.|
Pvisvspsptvtsggn..vtLtCsaeggpppptisWy.ietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 901-989 2.7e-07 25.1 In-house 135-224 (237) alignment 
Range on Protein: 901-989
Range on HMM: 135-224/237.0
VTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
. |.|.| |   |  ..  ..| .  ..    ..    .  ..|||  |||...|    . . ..| . |.|... ..|   ..|  .||
ihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqt
0044763 (Phosphotyrosine protein) phosphatases II 902-989 6.6e-07 24.6 In-house 76-156 (178) alignment 
Range on Protein: 902-989
Range on HMM: 76-156/178.0
TQFQITNWGSTGEVKNPQTILMIMEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQT
 |.. ...   |.   .. .| ..| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..
iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn
Ig_2 Immunoglobulin domain 715-789 9.3e-07 20.8 Pfam-A 12-80 (80) alignment 
Range on Protein: 715-789
Range on HMM: 12-80/80.0
EEGCQVHFKVKFKGTPTPFFNWYHNGEPVTDDYAHelrgdgsLLLVSVEEKHKGTYRFVANN-EAGTVSQQVVLTV
.||..| .  ...| ||| . ||..||...   .        |.. .|.....|||. .| | | ...|. | .||
tegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsvevtv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 898-991 1.4e-06 22.0 In-house 173-266 (439) alignment 
Range on Protein: 898-991
Range on HMM: 173-266/439.0
KQSVTQFQITNWGSTGEVKNPQTILMIMEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
...| ||. . |       .   .|  .  .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||...
ertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalc
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 901-959 1.8e-06 21.9 In-house 217-284 (350) alignment 
Range on Protein: 901-959
Range on HMM: 217-284/350.0
VTQFQITNWGSTGEVKNPQTILMIME--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAAT
| |.|. ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....   
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDs
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 849-895 2e-06 22.2 In-house 3-47 (250) alignment 
Range on Protein: 849-895
Range on HMM: 3-47/250.0
VGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDCpnEYVNACYVDT
|.   .||  ||.|.|. .|  |..| . .| |..  .|.|| ....
vakkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhg
subfamily_hpo-7_pd Subfamily hpo-7 899-999 2e-06 21.9 In-house 122-222 (263) alignment 
Range on Protein: 899-999
Range on HMM: 122-222/263.0
QSVTQFQITNWGSTGEVKNPQTILMIMEemyrTQrkRGNTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTVV
. |.... . |  . ...... || |..        |.  |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......| .
htvkhysykgWiekndpelareilnilk....va..rnskslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtPm

SINYSCYI
 . .| ..
qLafsilm
TMEM154 TMEM154 protein family 611-695 2.8e-06 18.7 Pfam-A 52-136 (146) alignment 
Range on Protein: 611-695
Range on HMM: 52-136/146.0
NGGSMTIVFIAVGAIVslLLIVIIIVIIIVVVLKKERFKKD--YDIVSSKNKPVTAEQNLTPYSTFNNNNGGYEEIGLERIQEATYS
.    ... |.. ..|  | .....|.|.|.. |. | |..   .  ... .    ...  . . | ..     || .| ...  .|
adqaelvlmiiiPsvv..LillllvvvilvikkkrkrrKqeetsedekedlqldeldsenvkvpifEedvpsvmeiEmeeldkwmns
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 924-992 3.5e-06 21.1 In-house 216-283 (297) alignment 
Range on Protein: 924-992
Range on HMM: 216-283/297.0
IMEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
.  | .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.  
lqleslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 897-992 4e-06 21.1 In-house 174-265 (307) alignment 
Range on Protein: 897-992
Range on HMM: 174-265/307.0
AKQSVTQFQITNWGSTGEvknPQTILMIMEEMYRTqRKRgNTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVS
  ......| .||   |    ||. |  .. .  . |   .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..|| . 
ksrtiqhlqwenwpdrgv...pqinltainlleav.ryd.tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 899-999 4.8e-06 20.8 In-house 116-216 (255) alignment 
Range on Protein: 899-999
Range on HMM: 116-216/255.0
QSVTQFQITNWGSTGEVKNPQTILMIMeemyRTQRKRgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTVV
. |. .. . |      .... || |.    .  |.    |.|||||  .|||| |  |            . .| . .|  ..|.  | .......| .
htvkhysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtPl

SINYSCYI
 . .| ..
qlafsilm
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 811-894 5.2e-06 20.5 In-house 3-81 (315) alignment 
Range on Protein: 811-894
Range on HMM: 3-81/315.0
VPVGQFGEFVANGhaKGNEGFRNQFMMLDSGESdHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDcpNEYVNACYVD
.|| ||  || .   .    | ..|  |   .  .  .|. .. |   ||. ||. .| .|..|  |  . |  ..|.|| |. 
ipvaqfpafvnkn..rhtalfseefhdlpdPdi.yrqrvaretinfkknryknilPldsarvkleviddsPd..sdyinasyik
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 811-894 6.2e-06 19.9 In-house 4-82 (392) alignment 
Range on Protein: 811-894
Range on HMM: 4-82/392.0
VPVGQFGEFVANGHAkgNEGFRNQFMMLDSGEsDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKDcpNEYVNACYVD
.|| ||  || . .   .  | ..|  | . .  .  ||. .  |.  ||. ||. || .|..|  |    |  ..|.|| |..
ipvaqfpafveknrh..salffeefhdlpgpd.iypqtvaqkeinlkknryknilpydsarvkleviddipd..sdylnasyip
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 895-991 6.5e-06 20.5 In-house 154-246 (290) alignment 
Range on Protein: 895-991
Range on HMM: 154-246/290.0
TGAKQSVTQFQITNWGSTGEVKNPQTILMIMEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVV
 . .  ||  .. .| ..   ....|.| ... .     |  .| ..||| | . |||.. |      |   |.| . . .|||. | |.   ...  
deeeftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsal
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 824-894 9e-06 19.8 In-house 4-66 (283) alignment 
Range on Protein: 824-894
Range on HMM: 4-66/283.0
HAKGNEGFRNQFMMLDSGESDHSVTVglTSSNKLLNRFANIVVYDDNRIILRPISGhkdcpnEYVNACYVD
....|. ||...  |   . |  ...  .. ||  ||. .||..| .|. |.. |       .|.||... 
rvnnnklfrevlkrlsvpdldadias..adenkrknrnqeivpadqwrvelksesr......dyinavfip
subfamily_PTPN9_pd Subfamily PTPN9 818-899 9.9e-06 19.8 In-house 5-83 (297) alignment 
Range on Protein: 818-899
Range on HMM: 5-83/297.0
EFVANGHAKGNEGFRNQFMMLDSGESDHSVTVGLTSSNKLLNRFANIVVYDDNRIILRPISGHKdcPNEYVNACYVDtGAKQ
|.||  ..||..| ..... . . .    ...  . .|   ||..... ||. |. |  .....    .|.|| .|| | ||
elvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvd.Gykq