Gene PTPRD-27 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP081_AA protein Get Run
AqueP081_AA_674-874 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 675-864 1.6e-104 343.9 In-house 77-266 (287) alignment
Range on Protein: 675-864
Range on HMM: 77-266/287.0
VLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIaLVIGEYNITLLNENTNNRYIERKFEVKNNN-TGVKQSV
| ..||||||||||||||||||||||||.||||||||||.||.|.||..||||||||...  .|.|||||.||||..|. |||||.||||.| .| ||.|
vfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqv

TQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
.|.|||||||||.|..|||||..|||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  
kqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveq

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 666-875 6.2e-100 328.8 In-house 73-286 (290) alignment
Range on Protein: 666-875
Range on HMM: 73-286/290.0
DMTTEEGCQVLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALvIGEYNITLLNENTNNRYIERKFEVKNN
| | |    . .|||||||..|....|..||...|||.|....||.||.|....|.....|.||||... .  .||..|.||||.| |.|||||.||||.
DCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknk

NT-GVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
|. | ||||||.|||||||||.|.||||||..|||||.||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||..
nsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqq

VQ----LYLAYEDRI
.|    ..| | |..
yqgifqivltyldsf

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 651-863 1.9e-56 186.5 In-house 56-270 (305) alignment
Range on Protein: 651-863
Range on HMM: 56-270/305.0
TVMKPKKPVIEEFPSDMTTEEGCQVLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIA-LVIGEYNITLLNE
|......  . | .|.  ..      ..|||.||..|.| .|. || ..||..| .  |. ||.|..  |.... |.|||| .      .||....| .|
tlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelkse

NTNNRYIERKFEVKN-NNTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVL
.| . |||||... . ..   ...|.|.|.|.|   | .. . ..| .|... ..|.|  .....||||..|||. .|.|    ....|.|.|.|||.||
ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevl

KSQRIQKPGSVQTVV
|  | .... |||  
kqlRskrmkmvqtld

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 677-868 2e-52 172.7 In-house 78-286 (301) alignment
Range on Protein: 677-868
Range on HMM: 78-286/301.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYNITLLNEN-----------------TNNRYIER
..||.|||.||.|..|| .| ..||..| .  ...||... ..|. .. |.||||...      |. ..|| ||.                 .|| ||||
idgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyier

KFEVKNNNtgVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGS
||.||...    ..|.|.|.|.|   | |..|.|.|..|...  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| 
kfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpga

VQTVV-SVQLY
|.|    ...|
VtTLeqytsiy

0050432 (Phosphotyrosine protein) phosphatases II 677-864 2.4e-50 167.0 In-house 99-287 (308) alignment
Range on Protein: 677-864
Range on HMM: 99-287/308.0
LKGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST--SIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQS
 .||  | ...||.. .|. ||  .||.|. . ||. || |. . ||..| |.||||..  .  |..| . .|||.| ... |. |..|..|...|    
vdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrt

VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
||.|. |||   |   .|. .| ..|.. ...   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||.  
vthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq

subfamily_PTPRD_pd Subfamily PTPRD 677-862 3.9e-50 166.0 In-house 84-267 (564) alignment
Range on Protein: 677-862
Range on HMM: 84-267/564.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSiALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQF
..||...||.| .  |. .| ..||.|. ..|.. ||.| . .|.... | .|||...    .||. .|| .|.. . |. |.|..|....  .. |.||
idgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqF

QITNWDSTGEVKNPQTILMIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. |.| ..|  ......| .|... ... ....  ||||||  |||. .|..    ... |.|...|..|..|  | |..  ||| 
hFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqte

0051299 (Phosphotyrosine protein) phosphatases II 677-863 5.5e-50 165.8 In-house 85-273 (288) alignment
Range on Protein: 677-863
Range on HMM: 85-273/288.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNN----NTGVKQS
..||. |..||... |. ||  .||.|. . ||. ||.|. . |...| |.||||. .  |..|.. .|||.| ... |. |..||.|.     .| .. 
idgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrt

VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
||.|. |||   |   .|. .| ....... ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||. 
vthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe

0046845 (Phosphotyrosine protein) phosphatases II 677-863 8.2e-50 165.1 In-house 65-261 (284) alignment
Range on Protein: 677-863
Range on HMM: 65-261/284.0
LKGY-----KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVKNNN-TGVK
..||     . ||.||..  |. ||  .||.|. . ||. || |. . ||..| |.||||...  |..|.. .|||.|.... |. |..|..|.. ||  
vdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytges

QSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVV
  ||.|..|.|   |   .|. .| ..... . ...  |.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||. 
rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle

0036941 (Phosphotyrosine protein) phosphatases II 677-863 8.4e-50 165.1 In-house 71-264 (297) alignment
Range on Protein: 677-863
Range on HMM: 71-264/297.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST-SIALVIGEYNITLLNENT--NNRYIERKFEVKNNNTGVKQSV
..||. |..||... |. ||  .||.|. . ||| || |. . |.. | |.||||..    |. |.. .|||....  .. |. |..||.....| .  |
vdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtv

TQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVV
|.|..|.|.  |   .|...| .||.. . ...  ... ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||. 
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle

0047943 (Phosphotyrosine protein) phosphatases II 677-862 1.4e-49 164.4 In-house 70-258 (273) alignment
Range on Protein: 677-862
Range on HMM: 70-258/273.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI--ALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVT
..||. |..||... |. ||  .||.|. . ||. || |. . |...| |.||||..     |. |.. .|||.|.|.. |. |..|..|..|| .  ||
vdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvt

QFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|. |.|   |   ... .| .||.. .....  .|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||.
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp

0045450 (Phosphotyrosine protein) phosphatases II 675-862 7.7e-49 162.4 In-house 72-290 (307) alignment
Range on Protein: 675-862
Range on HMM: 72-290/307.0
V--------------------------LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLN
|                          ||.||. |..||.. .|. .|  .||.|. . .||.|| |... |...| |.||||...  |..|.. .|||.
VklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtlls

ENTNNRYIERKFEVKNN-NTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---ID
|.. . |. |..||...  ||    ||.|. |.|  .|  ......| .|||. . ...  ... ..||||. |||...|.|| . .   ..||.   .|
eehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd

VFQVLKSQRIQKPGSVQTV
.....|  | |.||.||. 
lleavkllreqRpgavqnp

0040438 (Phosphotyrosine protein) phosphatases II 677-872 8.4e-49 161.9 In-house 62-273 (317) alignment
Range on Protein: 677-872
Range on HMM: 62-273/317.0
L-----------------KGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERK
|                 .|...|..||.. .|. ||  .||.|. . .|| || |... |...| |.||||.    |..|.. .|||.| ... .. |.
LsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrt

FEVKNNNTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSV
.||...... .  ||.|. |.|.  |  ..|...| ..|.. . .. .... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.|
levedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgav

QTVVS-VQLYLAYE
||    ..|| |  
qtpeqyrflydall

Y_phosphatase Protein-tyrosine phosphatase 677-862 1.1e-47 157.8 Pfam-A 35-223 (235) alignment
Range on Protein: 677-862
Range on HMM: 35-223/235.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWP-STSIALVIGEYNITLL-NEN-TNNRYIERKFEVKNNNTG-VKQS
.|||||||.||... |. .|   ||.|. ...|..||.|....|...| | |||| ...  |  |.....|  .|.  ...|. ||.|.|....   |..
vkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekre

VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
vkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

Y_phosphatase Protein-tyrosine phosphatase 677-862 1.1e-47 157.8 In-house 35-223 (235) alignment
Range on Protein: 677-862
Range on HMM: 35-223/235.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWP-STSIALVIGEYNITLL-NEN-TNNRYIERKFEVKNNNTG-VKQS
.|||||||.||... |. .|   ||.|. ...|..||.|....|...| | |||| ...  |  |.....|  .|.  ...|. ||.|.|....   |..
vkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekre

VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
vkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 678-863 8.7e-47 154.3 In-house 69-253 (283) alignment
Range on Protein: 678-863
Range on HMM: 69-253/283.0
KGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSiALVIGEYNITLLNENTNNRYIERKFEVKNN-NTGVKQSVTQF
| ||..| .||| ||. .| ..||||. |...||||.| .  |.... | ||||.   .   ||. .|| .| |.| .| ... ...|  .  .  .. .
ksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahy

QITNWDSTGEVKnPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|. .| . ||   .   |. .. .   |..  .. |||||| ..||.|.|.||...... .|| |.|||.|.|  | |... |||  
qvidWleygeqa.iinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtld

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 676-862 4.6e-46 152.4 In-house 91-276 (298) alignment
Range on Protein: 676-862
Range on HMM: 91-276/298.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAlVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQ
 |..||...|||... |. .|  .||.|. ......||.|   .| ..  . .|||..  .   || ...||....   .| ||..|.....  ...| |
flhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkeekerevrq

FQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. |.| . |. .| ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| 
lhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte

DSPc_SM00195 677-862 7.9e-46 151.9 In-house 62-248 (263) alignment
Range on Protein: 677-862
Range on HMM: 62-248/263.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNN-RYIERKFEVKNNNTGVKQSVT
.||...||..|..  |. .| . ||.|. ...|. ||.|. |.||..| |..|||..|    ..|.....| .... .  .| |..|......  ...||
ikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvt

QFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|..||   |  .... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
qyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

PTPc_SM00194 677-862 7.9e-46 151.9 In-house 62-248 (263) alignment
Range on Protein: 677-862
Range on HMM: 62-248/263.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNN-RYIERKFEVKNNNTGVKQSVT
.||...||..|..  |. .| . ||.|. ...|. ||.|. |.||..| |..|||..|    ..|.....| .... .  .| |..|......  ...||
ikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvt

QFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|..||   |  .... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
qyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 677-884 1e-45 151.2 In-house 82-289 (318) alignment
Range on Protein: 677-884
Range on HMM: 82-289/318.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSiALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQF
. ||..|||.| | .|. .| ..||.|. ..| . ||.| .|.|. .. . .||||   .  .|.  ..| .| . . |. |.|.|.....  .. | |.
idGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqy

QITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ-LYLAYEDRI
..|.|  .|  ... ..| .. .  ..|.| |.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  |||    . .| .  . .
hytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal

MSDYSMIHA
.|  . ..|
asgdtevda

0039614 (Phosphotyrosine protein) phosphatases II 676-862 2.3e-45 150.7 In-house 74-275 (297) alignment
Range on Protein: 676-862
Range on HMM: 74-275/297.0
LL------------------KGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQeVCYQYWPSTSIalVIGEYNITLLNENTNNRYI
 |                  .||.  ...||..  |. .|  .||.|. . .||.|| |. ..|...  |.||||...   . |.. .|||.. ... |.
klkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgyt

ERKFEVKNnnTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQK
 |..||.|  .|    ||.|| |.|   |   .....| ..|.. . ...  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.
vrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR

PGSVQTV
||.||| 
pgavqtp

0043336 (Phosphotyrosine protein) phosphatases II 677-862 6e-45 149.2 In-house 81-263 (278) alignment
Range on Protein: 677-862
Range on HMM: 81-263/278.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPstSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQF
..||. ...||..  |. .|  .||.|. . .|| || |. . |.... |.||||  .  |..|.. .|||.|.... |. |..||.|. .| .. ||..
vdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthy

QITNWDSTGEVKNPQTILMIIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. ..|   |   .....| ..... . ..   |. ..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.||| 
hylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp

0042113 (Phosphotyrosine protein) phosphatases II 678-862 3e-44 146.7 In-house 46-229 (245) alignment
Range on Protein: 678-862
Range on HMM: 46-229/245.0
KGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQ
.||. .. ||..  |. .|  .||.|. . ..|.|| |. | |.... |.||||. .  |..|.. .|||.|.... |. |..||.|. .. .. |....
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

ITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 ..|.  |.  .....| ..|.. . ... .|. ..||||. |||...|.|| . ..  ..|. .......|  | |.||.||| 
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtp

0040439 (Phosphotyrosine protein) phosphatases II 677-862 3.2e-43 143.5 In-house 47-232 (249) alignment
Range on Protein: 677-862
Range on HMM: 47-232/249.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQF
..||. |..||..  |. .|  .||.|. . ..|.|| |... |...| |.||||. .  |..|.. .|||...... |. |..|..|. .| .  |...
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

QITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|.|  .|  ......| .||..   ...   .. ..||||. |||...|.|| . ..  ..|. .|.....|  | |.||.||. 
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp

0045098 (Phosphotyrosine protein) phosphatases II 677-862 4.6e-43 143.0 In-house 59-258 (278) alignment
Range on Protein: 677-862
Range on HMM: 59-258/278.0
LKGYkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNN----NTGVKQS
..||  .|.||..  |. .|. .||.|. . ..|.|| |... |...| |.||||. .  |..|.. .|||.| ... |. |...| |     ... .  
idgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrg

VTQFQITNWDSTGEVKNP--QTILMIIEEMYRTQR------------KRGNTSIVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-
||......|.  |   .|  . .| ..|.. . ..              ... ..||||  |||.....|| . .  .  ||..|.....|  | |.|| 
vthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpgl

SVQTV
.||. 
avqnl

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 675-862 8.4e-42 138.1 In-house 43-228 (250) alignment
Range on Protein: 675-862
Range on HMM: 43-228/250.0
VLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEvCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVT
. |.||.|.||||.. .|. .|  .||.|. ......||.|   .|.... . ||||    |   |.  ..||....   |. ||. . ...   .. | 
sflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.ekaekyGdvtvsllskeefadytkrklklskakkaderivr

QFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.. ..|   |  .. ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |.| |.|||.|.|  |...|..|.. 
qlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 676-863 1.6e-41 137.4 In-house 83-270 (319) alignment
Range on Protein: 676-863
Range on HMM: 83-270/319.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIaLVIGEYNITLLNENTNNRYIERKFEVKNNNTGV-KQSVT
 . ||.|...|| . .|. ||  .||.|. ....  .|.|.. .|. .  . .|||.. .  . |.. .||..|.  . || ||........ |   .|.
fidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenf.eeyGrlivtleeeeeledyiirklklnkkssevetRevk

QFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.|| |.|   .  .. ...| ..... ....|  .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||.  
hfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpe

subfamily_PTPRA_pd Subfamily PTPRA 677-866 5.5e-41 135.5 In-house 94-285 (330) alignment
Range on Protein: 677-866
Range on HMM: 94-285/330.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIaLVIGEYNITLLNENTNNRYIERKFEVKNNNTG----VKQS
..|||||. || |  |  .|  .||.|| ... ..||.| . .| ..| |.||||.  . .  |. .... .|.  . |  ||| |.. . .     .. 
idGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrl

VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
|.||  | |   |   .|. .| ..... ..... .. .||||||  |||.  |..  . ... |.|...|||...|. | |.|  |||    .
vrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqye

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 677-875 4.9e-40 132.4 In-house 77-276 (281) alignment
Range on Protein: 677-875
Range on HMM: 77-276/281.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVkNNNTGVKQSVTQF
..|||..|..|....|. ..  .||.|. ...|.|||.. .| |...  |..|||  . .| .|.. .. ..|.....||||||.. ....| ...|.|.
vpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveql

QITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVS-VQLYLAYEDR
. |.|  .|  .... .|   .|......|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||||    .|.|  | 
aytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda

I
.
l

subfamily_Ptp69D_pd Subfamily Ptp69D 677-881 1.3e-39 131.1 In-house 84-287 (307) alignment
Range on Protein: 677-881
Range on HMM: 84-287/307.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTsIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGV-----KQ
.||||||| ||.|  |. .|. .||.|| . .|| ||.|  ..| |.. | .|||        |. ...| .|.. . ||.|...| ...  .     ..
ikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsr

SVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVsvQLYLAY
 |.|.. |.|. .   . ....| .||...  ...  .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  ||     |    |
kvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsle..qYvfly

edRIMSDYSM
  | . |||.
..ralldyss

0037934 (Phosphotyrosine protein) phosphatases II 684-862 5.6e-38 126.3 In-house 45-228 (243) alignment
Range on Protein: 684-862
Range on HMM: 45-228/243.0
KaFIIAESPMFNTARN----FWKMIDDRNVTAIVILCHENENNQEVCYQYWPsTSIalVIGEYNITLLNENTNNRYIERKFEVKNNN-TGVKQSVTQFQI
. .|.   |. .|  .    ||.|. . ..|.|| |... |...| |.||||  ..  ..|.. .|||.|.. . |. |.....| . ..... |.... 
r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhy

TNWDSTGEVKNPQTILMIIEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTV
..|   |   .|. .| ...|..  ...        ..  ..||||  |||.....|| . . ..   | .|.....|  | |.|| .||| 
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtp

subfamily_PTPRK_pd Subfamily PTPRK 676-862 3.9e-37 122.8 In-house 78-263 (314) alignment
Range on Protein: 676-862
Range on HMM: 78-263/314.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAlvIGEYNITLLNENTNNRYIERKFEVKNNN--TGVKQSV
|. .||  .|||..  |. .| ..||... | | ..||.| .  |. .  |..|||  .     |. ...|.. .... .. | | |.. .     .. |
lidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirev

TQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 ||| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||. .|.| .. ..  ..|||.|||.. |. | .|.  |.| 
rqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvete

subfamily_PTPN12_pd Subfamily PTPN12 676-863 1.2e-36 121.1 In-house 75-264 (290) alignment
Range on Protein: 676-863
Range on HMM: 75-264/290.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNN-RYIERKFEVKNNntGVKQSV
..|| ..|...| | .|. .|  .||.||.. ||. .|..|.| |...  | .|||..   .| .||...|| .|.. .  .. | ..|...  . ...|
fikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkv

TQFQITNWDSTGEVKNPQTILMIIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVV
.||. |.|   |  ......| .||.. ..|. . .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  |||  
yqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtke

subfamily_PTPRB_pd Subfamily PTPRB 677-863 1.3e-36 121.1 In-house 87-272 (293) alignment
Range on Protein: 677-863
Range on HMM: 87-272/293.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVKNnnTGVKQSVTQF
..||. .. || .  |. .|  .||.|. ......||.| .  |. .. | .|||... . . |. ..||..|.. . .. |......  .  ...|.|.
ipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqy

QITNWDSTGEVKNPQTILMIIEEMYRTQ-RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
. | |   |  ....|.| ..... ... ..  .. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||. 
hftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtek

subfamily_PTPRG_pd Subfamily PTPRG 677-884 2.4e-35 116.8 In-house 84-296 (563) alignment
Range on Protein: 677-884
Range on HMM: 84-296/563.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTG------VK
..||. .||||..  |. .|.  ||.|| ..||. ||..   .|.... | .|||.   .. .|. ..|| .|..   | .|.. .|| .         .
idGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdte

QSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS-VQLYL
. |.|.. |.|  .|  . .   |. ..   .....     ||||||  |||. ....  | ... ..| ...||..||  | |..  |||    . |. 
klvrqyhytkWPdhgvPehslpvLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhd

AYEDRIMSDYSMIHA
|  . |.|    . |
alleaiasketella

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 657-885 2.5e-35 117.1 In-house 64-298 (325) alignment
Range on Protein: 657-885
Range on HMM: 64-298/325.0
KPVIEEFPSDMTTEEGCQVLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNvTAIVILCHENENNQEVCYQYWPST-SIALVIGEYNITLLNENTNNRY
..|.|    |  ..      |. .|.|. |. | .|. .|  ..|... | . ...|..  | ..... | .|||   . .   |  .. |   ..   |
rvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdy

IERKFEVKNNNTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEM---YRTQR--KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKS
. |...||. . |  .|| |||.  ||  |  | | |.. |.. .     . .   .. | |.||||. |||. .| .  . ..|  .|  .|.|...| 
vhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkk

QRIQKPGSVQTVVSVQ-LYLAYEDRIMSDYSMIHAS
 | ..|  |.||     .| |  . .||  . .  |
lrkdrpsmvetvdqyiliyealveaymsgntdvpvs

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 677-873 3.2e-35 116.5 In-house 80-275 (315) alignment
Range on Protein: 677-873
Range on HMM: 80-275/315.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPS-TSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTgvKQSVTQ
.|.... ||.| .  |   .  .||.|. . .||.||.. . .|...  | ||||   . .   |.....||. ...   . ||. ... ..  .. |||
iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee..srtvtq

FQITNWDSTGEVKNPQTILMIIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSV-QLYLAYED
|| |.|   |  |.  ..| .| |.    ... . |..||||  |||. .....   ... | . ..|||...|  | ..|  |||      .| |  .
fqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 683-887 3.6e-35 116.5 In-house 91-296 (297) alignment
Range on Protein: 683-887
Range on HMM: 91-296/297.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQeVCYQYWPSTSIALvIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQITNWD
|. .|  . || .|  .||.|. | .|..||.| ..||...  | .||. ....   |.  ..||  .  . .|.|..||..... ... | |.| ..| 
khrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWP

STGEVK--NPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ-LYLAYEDRIMSDY
.  . .  . ...| .|.|.  .  .. .. ..|||.  ||| .....    . . | |  .|.|...|  | ..|  |||    . .| |  . ..|. 
dkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed

SMIHASQF
  |.|| |
triqasyf

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 677-899 2.4e-34 114.2 In-house 61-282 (284) alignment
Range on Protein: 677-899
Range on HMM: 61-282/284.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILChenennQEVCYQYWPSTsIALVIGEYNITLLNENTNNRYIERKFEVKN-NNTGVKQSVTQ
..||. |. .| .  |. ||  .||.|| . |...||.|       .. | ||||   |    ..... .   .  . |. |..|. .  .   .....|
itGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk.ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirq

FQITNWDSTGEVKNPQTILMIIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ-LYLAYED
| .  |   |  . |  ......   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  . .| |  .
fhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

-RI--MSDYSMIHASQFYDTDQNNDSIND
 ..   || ..     ...   |.  ..|
ehlfghsdvalpdfpayleelsnksdfdd

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 677-894 2.4e-34 114.1 In-house 97-313 (319) alignment
Range on Protein: 677-894
Range on HMM: 97-313/319.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILChenennQEVCYQYWPSTsIALVIGEYNITLLNENTNNRYIERKFEVKN-NNTGVKQSVTQ
..||. |. .| |  |. ||  .||.|| . |...||.|       .. | ||||   |    ..... .   .  . |. |..|. .  .   ....||
vtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplk.ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitq

FQITNWDSTGEVKNPQTILMIIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ-LYLAYED
| .  |   |  . |  ......   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  . .| |  .
fhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

-RI--MSDYSMIHASQFYDTDQNN
 ..   || .|     ...   |.
ehlfghsdvampdfpayleelsnk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 677-863 3.4e-34 113.2 In-house 83-266 (288) alignment
Range on Protein: 677-863
Range on HMM: 83-266/288.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVKnnNTGVKQSVTQF
..|.|.||..| . .|. .|  .||... ..... || | .  |.... | .|||..      |. ..||..... . ...||....   .. .  .||.
idgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqy

QITNWDSTGEVKNPQTILMIIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
| . |  .|  .. . .| ... .  .. .     |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||. 
qylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlk

subfamily_PTPN23_pd Subfamily PTPN23 685-866 4.5e-34 112.6 In-house 84-270 (288) alignment
Range on Protein: 685-866
Range on HMM: 84-270/288.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQITNWDS
 ||.. .|. .|.  ||.|. .. .  ||.| ...| ... . .|||.    . . |....|| .... . ..||..... ...  ..||.  |.|.| .
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpe

TGEVKNPQTILMIIEE---MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
 |  . |.|.| ...|   .|...... .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||..  ..
lGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk

subfamily_PTPN6_pd Subfamily PTPN6 682-866 7.6e-34 112.1 In-house 96-287 (306) alignment
Range on Protein: 682-866
Range on HMM: 96-287/306.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVK-NNNTGVKQSVTQFQITN
..|..| ..  . .|  .||.|. . | . ||.. .|.| ..| |..|||...     |....| ..|.....|| |.. |. ... . ...| |.. ..
sdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfks

WDSTGEVKNPQTILMIIEEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVVSVQ
|   |  |.|...|  .|.. | |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | |||    .
WPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqyk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 676-866 1.4e-33 111.2 In-house 84-269 (315) alignment
Range on Protein: 676-866
Range on HMM: 84-269/315.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTsiALVIGEYNITLLNENTNNRYIERKFEVKNNNTgVkQSVTQ
...||. |. .| |..|  .. ..||... . ... ||.|    |.... . .|||     .. |.. .|. .|. |..|  | . |  ..  . . | |
fidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdn.i.revvq

FQITNWDsTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
...| |  . .| .  . || .    .  ..   ..||||||. |||.  |..  . ... ..| .|||.....  | .. . ||..   |
lhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyq

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 677-864 2.1e-33 110.2 In-house 79-264 (515) alignment
Range on Protein: 677-864
Range on HMM: 79-264/515.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPS-TSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTgvKQSVTQ
.....  ||.| .  |   .  .||... . |||.|... . .|...  | .|||   . ..  |.... |.  ..    | ||..|  ..    . |||
ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtq

FQITNWDSTGEVKNPQTILMIIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
|. |.|   |  |. ...| .| |. .... . . ....|||  |||  .....   . . ||  ..|||....  | ..|  |||   
fhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeq

subfamily_PTPN3_pd Subfamily PTPN3 684-863 1.1e-32 108.1 In-house 84-262 (280) alignment
Range on Protein: 684-863
Range on HMM: 84-262/280.0
KAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQITNWDS
. .|..  |. .|| .||.|. ..... ||.|    |. .  |.||||.|.  |  ||..... .|.... |. |.. .|...|  .....|.| ..|  
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpd

TGEVKNPQTILMIIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  |.. .  ..  . . ....  | |.   |||. 
hgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtas

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 676-863 2.3e-32 107.2 In-house 64-255 (274) alignment
Range on Protein: 676-863
Range on HMM: 64-255/274.0
LLKGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIG---EYNITLLNENTNNRYIERKFEVKNNNTgvKQ
 .|||.| .||.. .  |. ||  .||.||  ..|. ||.| . .|.|.. | .|.| .  . . .   . .|.  . ...| |  ||. .|. .   ..
yikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..er

SVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
||. .  |.|  .   ....|.| ...|. ...... .   ..|||||  .||  .| |.  .... . |.|.||...    |... | |||  
svkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtse

subfamily_PTPN9_pd Subfamily PTPN9 677-861 1.9e-31 104.2 In-house 78-275 (297) alignment
Range on Protein: 677-861
Range on HMM: 78-275/297.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWP-STSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQ
. |||.||||| .  |. .| ..||.|. ...|  ||.  .  |. .  | |||| ..  .   |..... .. .... | .|..|.|| .|. ...|| 
vdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvth

FQITNWDSTGEVKNPQTILMIIEEMYRTQR---------KRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
||.. |   |  .. ...| ..|.. ..|          ..|   .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.||
fqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqt

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 677-873 8.3e-31 101.8 In-house 73-272 (287) alignment
Range on Protein: 677-873
Range on HMM: 73-272/287.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNE-NTNNRYIERKFEVKNNNTGVKQSVTQ
. .|....||| | .|.  | |.||... .......... .| |. .  ||.|||     . .| | ..||.  . .  |  | . . . .|   . | |
vasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkq

FQITNWdsTGEVKNPQ---TILMIIEE--MYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVsvQLYL
... .|    .|  |     | ....       .|.  .   .|||..  .||| .. |  . ... .  | .|| .|.   | .. . ||.||  || |
ldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavv..qlrl

AYED
 || 
lyea

subfamily_PTPN1_pd Subfamily PTPN1 680-872 3.8e-30 99.6 In-house 67-265 (290) alignment
Range on Protein: 680-872
Range on HMM: 67-265/290.0
YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI--ALVIG--EYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQ
 . |. .|..  |. ||.  ||.|. ...  |.|.| .  |..|  |.||||.     .|..   .....|..|.... |. |..|..| .|   .....
eeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilh

FQITNWDSTGEVKNPQTILMIIEEMYRTQR-KRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVVsvQLYLAY
|  | |   |  . |.. |  . .. ..   ..     |.|||  .|||  || . | .    | .    .|. .||   | .. | .||    || ..|
fhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtad..qlrfsy

E
 
l

subfamily_CG7180_pd Subfamily CG7180 658-863 1.1e-28 94.8 In-house 59-277 (296) alignment
Range on Protein: 658-863
Range on HMM: 59-277/296.0
PVIEEFPSDMTTEEGCQVLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQeVCYQYWPSTSiALVIGEYNITLLNENTNNRYIE
.|.|..  . ...    |   ..  ||..|. | |. .|  .||... |... |.|.|... . ..  . .||| .|     ||  . ...|..      
vvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlki

RKFEVKNN-------NTGVKQ---SVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRG-----NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVI
|.| .. .       ...||     |..||.| |..  .|    . |. . .. |. |..      .  .||..|| ..|| ...|.  .... . |. .
rtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeev

DVFQVLKSQRIQKPGSVQTVV
|||. .|  |...|. |..| 
dvFeavktlrrsRpqLvenve

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 678-867 1.1e-28 95.1 In-house 57-255 (270) alignment
Range on Protein: 678-867
Range on HMM: 57-255/270.0
KGYK-EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS---IALVIGEYNITLLNENTNNRYIERKFEVKnnNTGVKQSV
.|.. |||..| | .|. .| ..||.|| ...|||||.. . .|.... | .|||. .   ..|  |. ... |.|. .. || .. ...  ..| .. .
rGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrl

TQFQITNWDSTGEVKNP------QTILMIIEEMYRTQRKRGN-TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
. |. ..|   | ....      . .| ..... |....  . . ..||||. |||. .. |  ....  .... .|| ....  | ...  ||... ..
vHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqye

L
.
f

subfamily_PTPN13_pd Subfamily PTPN13 681-862 3e-28 93.9 In-house 74-255 (273) alignment
Range on Protein: 681-862
Range on HMM: 74-255/273.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIA--LVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQI
|..  .|..  |. .|...||.|. ..... |... .| |...  | .|||..      | . ....||. .  . .  |...||....|  . |.... 
kdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnf

TNWDSTGEVKNPQTILMIIEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
..|   |  .... .| .. |. | |.   .. ||||||  .||| .. .  . ..  . .  .|| ..... | |. | ||| 
vkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtk

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 676-862 5.5e-28 92.7 In-house 64-245 (267) alignment
Range on Protein: 676-862
Range on HMM: 64-245/267.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNqeVCyQYWPST-SIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVkQSVT
 ..||| |.|||. . |. ||  .|...| |..|. ||.| .  ..|  .  ..||     |    .  .    |. .| |    .|.| .|    . ||
yvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn..ir.lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa.hnvt

QFQITNWDSTGEVKNPQTILmiIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .   .|.   . |     |  .  . . | . ||  .||.||| ||||  |  . . ... ||||| |.|. |.  | |..| |.| 
lyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk

subfamily_PTPRN_pd Subfamily PTPRN 683-867 1e-27 91.7 In-house 99-283 (297) alignment
Range on Protein: 683-867
Range on HMM: 99-283/297.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAlVIGEYNITLLNENT-NNRYIERKFEVKNNNTGVKQSVTQFQITNW
. |.| ...|. .|  .||.|. .. |. || |.. .|.. . |..||| .  . | . |.. |. |    . |. | | .|| .|   ..||||    |
apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflsw

DSTGEVKNPQTILMIIEEMYRTQRKRGnTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVSVQL
 ..|   .....|     . .. | |  ..||||||| .||. ....    .|.  |    ||.   |.  | |.|| |.|    ..
peegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef

0036282 (Phosphotyrosine protein) phosphatases II 678-861 2.8e-26 87.7 In-house 11-155 (174) alignment
Range on Protein: 678-861
Range on HMM: 11-155/174.0
KGYKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStsialvigeynitllnentnnryierkfevknNNTGVKQSVTQFQ
...   . .|.   |.      ||.|. . ..|..| |..|.|.. . |..|||.                                . .  .... |..
dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lredlerlgiqyl

ITNWDSTGEVKNPQtILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQT
 ..|.  |.   .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||
ylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

0051429 (Phosphotyrosine protein) phosphatases II 679-871 1e-25 86.3 In-house 14-220 (272) alignment
Range on Protein: 679-871
Range on HMM: 14-220/272.0
GYKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVILCHENENNQEVCYQYWP-----------STSIALVIGEYNITLLNENTNNRYIERKFEVKN
||     ..... .  |. .||..||..  . ....|| |..|.| ... |..|||           ..     .| . .||| | . . || |......
gygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltl

N-NTGVKQSVTQFQITNWDSTGEVKNPqtILMIIEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------VFQVLKSQRIQK
  ..|    |.... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        ......  | | 
llsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqr

PGSVQTVVSVQLYLAY
||.|||   ..  . .
pgavqteeqylflyea

subfamily_PTPN14_pd Subfamily PTPN14 682-863 6.1e-25 82.8 In-house 91-283 (300) alignment
Range on Protein: 682-863
Range on HMM: 91-283/300.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST---SIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQI
... .|.| .|. .| ..||.|. . .|. ||.| .|.|. .| ...|.|..      .  |....|    .. ...| .....|   .. ...|  .| 
kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy

TNWDSTGEVKNPQTILMIIEEMYRTQRKRGNT--------SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|.|   |  ..... |  .||.   .||  ..         ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. 
tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtla

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 683-868 1.3e-24 81.4 In-house 89-271 (301) alignment
Range on Protein: 683-868
Range on HMM: 89-271/301.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST-SIALVIGEYNITLLNENT--NNRYIERKFEVKNNNTGV-KQSVTQFQI
 . ||.. .|. ||. .|| |.   .|  ||.|... |...|.| .| |.. |  | || ..|.. |...  |.. ..|..||..    .  ..|| .| 
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqy

TNWDSTGEvknPQTILMIIEEMYRTqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVvsVQLY
..|   |    |..   . . |     |. .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||.   |||
sewtdrgv...Pkshaelfdlmelv..kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn..sqly

0049260 (Phosphotyrosine protein) phosphatases II 677-872 1.4e-23 78.7 In-house 2-146 (152) alignment
Range on Protein: 677-872
Range on HMM: 2-146/152.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWpstsialvigeynitllnentnnryierkfevknnntgvkqsvtQF
..||. ...||... |. ||. .||.|. . ..|.|| |. . |.. . |.||.                                            |.
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qy

QITNWDSTGEVKNPQTILMIIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVVSVQLYLAYE
. ..|.  |  ...| .|.... . .  ... .  ..||||  |||.....||   .        ........  | ..||.|..    .. . .|
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflyefe

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 683-862 5.6e-23 76.4 In-house 44-225 (237) alignment
Range on Protein: 683-862
Range on HMM: 44-225/237.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVK-QSVTQFQITNW
 | .| |. |. ..  .||.|. . . . ||.|    |.|.. |..|||||      | . ..|  ..    |  | . . .. |  . . . |.|.| |
pkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftsw

DSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
   |  ..  ..| .  ..    ..    .  ..|||  |||...|    . . ..| . |.|... ..|   ..|  .|| 
pdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtk

0041856 (Phosphotyrosine protein) phosphatases II 677-862 1.5e-22 75.5 In-house 27-157 (182) alignment
Range on Protein: 677-862
Range on HMM: 27-157/182.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILChenennqevCYQYWPstsialvigeynitllnentnnryierkfevknnnTGVKQSVTQF
. |.   . ||..  |. .|  .|..|. ....|.|| |.         ...|||                                   . ... ..|.
ylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...................................ellerlgiqy

QITNWDSTGEVKnPQTILMIIEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDVFQVLKSQRIQKPGSVQTV
. ..|.  |    ....| .|||...      .  ..||||  |||.....||   . .    | .......|  | ..||.|.| 
lylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitp

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 683-863 1.9e-22 74.3 In-house 93-270 (290) alignment
Range on Protein: 683-863
Range on HMM: 93-270/290.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTN-NRYIERKFEVKNNNTGVKQSVTQFQITN
|  ||... .. .|. ..|.|. . .|.|||.||   |. .  | ||.| ..  .| .||. ..  .|... .. | . . |.. ..| .  .  ..|  
kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkiks

WDSTGeVknPQTILMIIEeMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTVV
|     |  ... | ..  . |. ||  .  .|||||  .||.  | |  ... .. ..|  .|. .. .. |  . .|||  .
wpdks.v..alstlallr.tlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdi

0043147 (Phosphotyrosine protein) phosphatases II 677-874 3.6e-21 71.1 In-house 13-159 (172) alignment
Range on Protein: 677-874
Range on HMM: 13-159/172.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHEnennqevcyqywpstsialvigeynitllnentnnryierkfevKNNNTGVKQSVTQF
|..|   . ||.   |. ||   ||.|. ....|.|| |. .                                             .. ....... |.
ldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpellerlgiqy

QITNWDSTGEVkNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVVSVQLYLAYEDR
. ..|.  |   ... .| ..| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||.    .. . .|..
lylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyfekl

0046846 (Phosphotyrosine protein) phosphatases II 685-862 1.9e-20 68.8 In-house 24-159 (176) alignment
Range on Protein: 685-862
Range on HMM: 24-159/176.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStsialvI----GeynitllnentnnryierkfevknnntgvkqsvtQFQITN
..|.   |. .|  .|..|. . ..||.| |. | | ..  |..|||       .                                       |.. ..
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe......leklgi..................................qylhlp

WDSTGEVKNpQTILMIIEEMYRTQRKRgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTV
|.  |     . .| ..|.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.||| 
wpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 673-862 9.5e-20 65.8 In-house 39-226 (239) alignment
Range on Protein: 673-862
Range on HMM: 39-226/239.0
CQVLLKGYK-EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAlvIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQ
    |. |    ||.| ..  .  .. .||.|. .     ||.|    |  .. |.|||| ..      .  .|| . .    || | | . .     ..
nasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..ycnlrvtlrktevfadyiirtfvmsqvgqteer

SVTQFQITNWDSTGEVKNPQTILMIIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 | |...| |   |  .   ..| .  ..   .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
yvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 673-862 1e-19 65.6 In-house 40-227 (239) alignment
Range on Protein: 673-862
Range on HMM: 40-227/239.0
CQVLLKGYK-EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAlvIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQ
    |. |    ||.| ..  .  .. .||.|. .     ||.|    |  .. |.|||| ..      .  .|| . .    || | | . .     ..
nasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..ycnlrvtlrktevfadyiirtfvmsqvgqteer

SVTQFQITNWDSTGEVKNPQTILMIIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 | |...| |   |  .   ..| .  ..   .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
yvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 676-864 3e-19 63.8 In-house 83-267 (439) alignment
Range on Protein: 676-864
Range on HMM: 83-267/439.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENEnnqevCYQYWPSTSiALVIGEYNITLLNENTNNRYIERKFEVKNNN--TGVKQSV
 .||| ..| .| .. |  .|. .||... ..... || |.   |      |.|||| .   . |.  .    .    .|. | | | |.   |  ...|
yikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve.....sykywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertv

TQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
 ||. . |       .   .|  .  .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||... 
lqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcq

PTPc_DSPc_SM00012 773-864 5.5e-19 63.7 In-house 2-95 (105) alignment
Range on Protein: 773-864
Range on HMM: 2-95/105.0
VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVS
|.....|.|  .|  .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.|||   
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeq

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 677-871 1.3e-18 61.6 In-house 81-232 (392) alignment
Range on Protein: 677-871
Range on HMM: 81-232/392.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNqevcyqywpstsialvigeynitllnentnnryierkfevknnNTGVKQSVTQF
..... .||.| ...|   .  .||.|. . |||.|... . .| .                                           .   ...|.||
ipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqf

QITNWDSTGEVKNPQTILMIIEEMyrtQRKRGNTS--IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSV-QLYLAY
..|.|   .  |   ..| .|.|.   . . |. .  ...|||  |||...  .  . . ..|.  ..|||...   | ..|  |||      .| | 
hftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 682-883 1.1e-17 59.0 In-house 80-280 (307) alignment
Range on Protein: 682-883
Range on HMM: 80-280/307.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNNRYIERK---FE---VKNNNTGVKQSVT
. | || |. |. ||  .|| |. . .| ....||.  |  .  | ||||      || || . |.  .|   . .       .   .| . ..  ....
kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiq

QFQITNWDSTGevkNPQTILMIIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVSvqlYLaYED
..| .||   |    ||. |  |. .  .. .  .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..|| .    || |  
hlqwenwpdrg...vpqinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaq...yl.ylh

RIMSDYSMIH
|.. .| .  
rvlleyflel

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 683-864 3.1e-17 57.2 In-house 80-257 (281) alignment
Range on Protein: 683-864
Range on HMM: 80-257/281.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNNRYIERKFEVKnnNTGVKQSVTQFQITNW
|. .|... |  .|  .||.|| . | ||||.||.  | |.| | .|.|  .  .| . .. ..  .   |.  .  ....     |  . .|..   .|
krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls..yegetrlithwlwkew

DSTgEVKNPQTILMiieEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG-VIDVFQVLKSQRIQ-KPGSVQTVVS
    .| .   ...   .. |  | |  |  |.|||  ||||  . |   ...  ..   . |. |..   |.  .  ||||.  
pdw.qvpessevml...kilrkirar.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqq

0051082 (Phosphotyrosine protein) phosphatases II 689-866 1.2e-16 56.1 In-house 18-143 (151) alignment
Range on Protein: 689-866
Range on HMM: 18-143/151.0
AESPmfntARNFWKMIDDRNVTAIVILCHENENNqeVCYQYWPSTSialvigeynitllnentnnryierkfevknnntgvkQSVTQFQITNWDSTGEVK
   |       |.... . ....|| |. | |..   |..|.|...                                      |....|..|. .|   
sggp....ladflellkelgiktivnlrseeerg..ycpeylpelg....................................ievlhipildwpdpglpl

NPQTILMIIEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVVSVQ
.....| ..|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||.    .
sfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

0049772 (Phosphotyrosine protein) phosphatases II 678-873 2.1e-16 56.0 In-house 81-274 (314) alignment
Range on Protein: 678-873
Range on HMM: 81-274/314.0
KGYkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVI---------------------LCHENENNqevcyQYWPSTSIALVIgeyni
.|.   ..||... |. .|  .|          |.|.  .|.||  ||.                     |.   .|.      ...   ..|       
dgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk.....

tllnentnnryierkfEVKNNNTGVKQSVTQFQITNWDStGEVKNPQTILMIIEEMYRTqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTeGVIDV
                |. ...  ... . ..  ....  |..  .. .. ..| . .    . .. ..|||.. .||.. |..||  . ...   . ..
................eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleea

FQVLKSQRIQKPGSvQTVVSVQLYLAYED
.. ....|  .|    .. . ..|. ...
ledvrlkRpinpnp.gfieqleqyefile

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 689-866 4.4e-16 53.2 In-house 96-278 (302) alignment
Range on Protein: 689-866
Range on HMM: 96-278/302.0
AESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST-SIALVIGEYNITLLNENTN-NRYIER------KFEVKNNN--TGVKQSVTQFQI
   |  .|   .| .|.. ||. .| ||.  |.... | .|.       |  |.| .. .. .|. ... ..      . |.||..  . ||..|  .. 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWDSTGEVKNPQTILMIIEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
. |   |  |...| | |.   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||.   . 
sawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 683-882 8e-16 52.5 In-house 95-291 (305) alignment
Range on Protein: 683-882
Range on HMM: 95-291/305.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLlNENTNNRYIERKFEVKNNN------TGVKQSVTQF
.| || |. |. .|  .|| |. ...|  ||.||.  |  .  | |||| .    .     | . .. . .. .||  |..          . | || ..
ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivv.envsgskpmerdaeiqitllnltysgdqkmsvrhl

QITNWDSTGEvknPQTILMIIEEMYRTqRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVSvqlYLaYEDRI
| |.|   |    |   |  .| .    |   .  ||||||  .||.    |    ..|   .  .  . ...|. | |.  |.|. |    || .  |.
qwtewpdrgv...ppckltslellsai.r.gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvq...yl.fihrv

MSDYSMI
| .| . 
mlnyfle

0044763 (Phosphotyrosine protein) phosphatases II 698-866 1e-15 53.3 In-house 38-161 (178) alignment
Range on Protein: 698-866
Range on HMM: 38-161/178.0
RNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIalvigeynitllnentnnryierkfevknnntgvkqsvTQFQITNWDSTGEVKNPQTILMII
 ...... . ..|.|| |..| |.... |..|||.                                          |.. ....  |.   .. .| ..
addlellkelgithivnlteelelgflkcdpywpeeag......................................iqylhipipDhgvpdllehflefv

EEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVVSVQ
| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..   ..
efieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlr

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 678-864 1.7e-15 51.8 In-house 76-259 (288) alignment
Range on Protein: 678-864
Range on HMM: 76-259/288.0
KGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYnITLLNENT--NNRYIERKFeVKNNNTGVKQS-V
   | |. .| |..|.  |  ..|||. . .|  ||.||.  |  .|   .|.||    .  || .  |   ..    .. ..    ......| ..  |
ssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl.ctvvkkkradidklvkvsl.lriskegeekviv

TQFQITNWDSTGEVKNPQTILMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
 .  . .||  |  .| .. | ..| .     |  .  ||||.|  |||.. .      ..  . .  . . ..|.. | ..  ..||   
kilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemq

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 690-860 3.6e-15 50.9 In-house 66-243 (290) alignment
Range on Protein: 690-860
Range on HMM: 66-243/290.0
ESPMFN-------TARNFWKMIDDRNVTAIVILCHENENNQE----VCYQYWPSTSI-ALVIGEYNITLLNENTNNRYIERKFEVKNNNtGVKQSVTQFQ
.||  .       |  .|| |. . .|. .| ||  .|....     | .| | .    | ..  ..   .  ...  ..|. .|| .. ...  ||  .
qsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsl

ITNWDSTGEVKNPQTILMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQ
. .|...   ....|.| .|. .     |  .| ..||| | . |||.. |      |   |.| . . .|||. | |.   ..
lkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralait

subfamily_CG42327_pd Subfamily CG42327 654-800 3.6e-14 47.1 In-house 41-190 (319) alignment
Range on Protein: 654-800
Range on HMM: 41-190/319.0
KPKKPVIEEFPSDMTTEEGCQVLLKGYKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI---ALVIGEYNITLLNE
 . ..| .. ..|  .|      ..||.. .. .| |. .. ... .||... ...   || |.   |.  .|| .|.|.        . |.. .|| . 
PetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgr

NTNNRYIERKFEVKNNNTGVKQSVTQFQItNWDSTGEVKNPQTILMIIEEM
....||.   . .|. .    . .| .   .|  ..   ...... .. |.
evkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev

subfamily_egg_pd Subfamily egg 684-864 5.9e-14 46.4 In-house 83-258 (307) alignment
Range on Protein: 684-864
Range on HMM: 83-258/307.0
KAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENnqEVCYQYWPS---TSIALVIGEYNITLLNENTNNRYIER--KFEVKNNNtGVKQSVTQFQi
  ||.|..|. ||  .||.|.   .|  ||.|    |.  | |  |||     |. .| | ..|. |. . .   . |  |. .   .   .. .  .| 
nefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwq.

TNWDSTGEVKNPQTILmiieemyRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVVS
 ... ...|  |  .|       |  |.   . .||.. . | ..| . |. ... .    | |  . ||..    | ... ||..|. 
gdvnnssdvysplrvl.......rklrnl.skpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvll

subfamily_hpo-7_pd Subfamily hpo-7 680-862 8.3e-14 46.1 In-house 31-213 (263) alignment
Range on Protein: 680-862
Range on HMM: 31-213/263.0
YKEK---KAFIIaespMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYNITllNENTNNRYIERKFEVKN--NNTGVKQSV
 |.|   . ...    . .|  .|...|   . . .|.||  ||...| | .|.|      ... . |..    .. .  . .  |. .  ..    . |
ekdkkrknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc..ttkvqsdvllktlellstlgeKkkthtv

TQFQITNWDSTGEVKNPQTILMIIeemyRTQrkRGNTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTV
.... . |  . ...... || |.    .    |.  |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......| 
khysykgWiekndpelareilnil....kva..rnskslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtP

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 681-862 8.7e-14 46.2 In-house 29-207 (255) alignment
Range on Protein: 681-862
Range on HMM: 29-207/255.0
KEK---KAFIIaespmfnTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYNITLLNenTNNRYIERKFEVKNNNTG--VKQSVT
|.|   . ...       |  .|...|   . . .|.||  .|...| | .|.|      |.. . |.|  .  . .  . |  |.  . .     . |.
kdkkrknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvk

QFQITNWDSTGEVKNPQTILMIIeemyRTQRKRgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTV
 .. . |      .... || |.    .  |.    |.|||||  .|||| |  |            . .| . .|  ..|.  | .......| 
hysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtP

fn3 Fibronectin type III domain 270-352 1.2e-13 44.1 Pfam-A 3-83 (85) alignment
Range on Protein: 270-352
Range on HMM: 3-83/85.0
VDDIFFSSVESMSITVSWDEVPcnGRNGPITGYYLTYTNITSNT-SYTVNITGGNNrMYNLTGLIPYTNYTVSIIPYNYNMNGP
. .. .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|||| |.|.|....  .| . .||
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 685-833 1.2e-13 45.5 In-house 105-286 (350) alignment
Range on Protein: 685-833
Range on HMM: 105-286/350.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAL-----------VIGEYNITLL-----NENTNNRYIERKFEVKNNNT-
 .| . .|. .|  .|.|.|   .|. |. |  . |.| | ||.||.  |.             ..|  ...|      .| ..|  |. . ..|.||. 
kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsl

-GVKQS------VTQFQITNWDSTGEVKNPQTILMIIE--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAATTI
  .. .      | |.|. ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....    .
taitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDsll

fn3 Fibronectin type III domain 375-446 1.5e-13 43.8 Pfam-A 11-84 (85) alignment
Range on Protein: 375-446
Range on HMM: 11-84/85.0
RTPTRINTVWNPPTIPNGIITVYEIRYRESTSTG-PYNITNTTNT-YYSIAGLIPNTSYTIGVRAYTSIGPGEW
.|.| ..  |.||. ..| || ||..|||..... . ..|.. .|  . . || |.|.|.. |.|..  | |..
vtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 681-864 2.1e-13 44.9 In-house 72-258 (285) alignment
Range on Protein: 681-864
Range on HMM: 72-258/285.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALV-IGEYNITLLN--ENTNNRYIERKFEVKNNNTGVKQS--VTQ
|.. ..| .. |. .|  .||.|| . ... ...||   |   | |  |.|     .| .|.|.||| .  |..    |   . | | .    .   . .
kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnh

FQITNWDSTGevkNPQTILMIIeEMYRTQRK--RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
 |.  |        |.    .| |.|.  .|    .. |.||||  |||.| |     .  .   .  |.......  |  .  .||. . 
vqvpwwpdql...apedarpmi.elykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmq

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 681-860 4.6e-13 43.8 In-house 2-188 (199) alignment
Range on Protein: 681-860
Range on HMM: 2-188/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYNITLLNENTNNRYIERKFEVKNNNTGV--KQSVTQFQ
| .. .| .. |. .|  .||.|. .     ||..  .. |..     |||.|   .   |  ..|     |.  |    . . || |     . ....|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

ITNWD--STGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQ
.| |   .| .|     ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . 
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiis

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 682-860 6.4e-13 43.3 In-house 2-187 (198) alignment
Range on Protein: 682-860
Range on HMM: 2-187/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYNITLLNENTNNRYIERKFEVKNNNTGV--KQSVTQFQI
 .. .| .. |. .|  .||.|. .     ||..  .. |..     |||.|   .   |  ..|     |.  |    . . || |     . ....|.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWD--STGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQ
| |   .| .|     ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . 
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiis

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 683-864 7.5e-13 42.7 In-house 93-278 (310) alignment
Range on Protein: 683-864
Range on HMM: 93-278/310.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIER-KFEVKNNNTGVKQSV-----TQF
...|| .. |.  |  .||.|| .    .|..||.  |. .  |  ||||  ..   |   .| |.| ...  |         .|  | .        . 
rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrv

QITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNtsIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
.. .|    .   |.     . .   .| . |    |||||  ..|  . .|   .|.| .    .|. .|    . ..   .|| . 
slikwpnwpdrgvpdekchtvpqrllaqvrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelq

subfamily_ptpA1_pd Subfamily ptpA1 683-837 1.3e-12 42.2 In-house 88-257 (418) alignment
Range on Protein: 683-837
Range on HMM: 88-257/418.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST------SI----ALVIGEYNITLLNEN--TNNRYIERkfEVKNNNTGVK
 | || .. |. ||  .||.|. .  .  ||.| .|.|| .  | .|||        ||      |.| |.. |..     .   | |  ...    |  
pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitr..nirltfeget

QSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRK-----RGNTSIVVHCSDTVGRSAMFCAAATTINKCK
. .||.|   |         | .  ..  .   | .       |  |.||||  |||.  ||.|   ..|  
rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkld

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 662-782 1.7e-12 41.4 In-house 214-329 (440) alignment
Range on Protein: 662-782
Range on HMM: 214-329/440.0
EFPSDMTTEEGCQVLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILcheNENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFE
..|.  | .   |  ..||  |.||| .. |.  |  .||... | ....|..|   |. |.  |  |||  . .. .| . .     .  ||   | .|
qwpnphtdksplqqefegyskknafiatqmpldstvldfwrlvhdyristiiml...nqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtle

VKNNNTgVkQSVTQFQITNWD
.| ..  | . . ||..  | 
lkykee.v.heirqfevqtwp

0048076 (Phosphotyrosine protein) phosphatases II 748-864 5.1e-12 41.2 In-house 22-131 (145) alignment
Range on Protein: 748-864
Range on HMM: 22-131/145.0
NENTNNRYIERKFEVKNNNTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQV
 |.  .  | . . . .. ..... ..|.. ..|.  |.   ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleea

LKSQRIQKPGSVQTVVS
|.  | | ||.|...  
lelvrsqrpgavpnpgq

0048179 (Phosphotyrosine protein) phosphatases II 703-864 6.9e-12 40.8 In-house 24-133 (144) alignment
Range on Protein: 703-864
Range on HMM: 24-133/144.0
MIDDRNVTAIVILCHENENNQEVCYqywpstsialvigeynitllnentnnryierkfevknnntgvkqsVTQFQITNWDSTGEVKNPQTILMIIEEMYR
.. . ..|... |..| |.. . ..                                             ..|.. ..|.  |    .. .| ..| . .
llkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefiee

TQRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVVS
 ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|..   
ale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgq

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 771-863 4.7e-11 36.7 In-house 89-181 (440) alignment
Range on Protein: 771-863
Range on HMM: 89-181/440.0
QSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
... |..   |   |  |    .| .|...  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  |||  
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 683-862 4.9e-11 36.9 In-house 87-273 (305) alignment
Range on Protein: 683-862
Range on HMM: 87-273/305.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS---IALVIGEYNITLLNENTNNRYIERKFEVKNNNT--------GVKQ
 | || ...|. .|  .|| |  . .| || .||   |   . |..|..|     . .  ..  |..  | ...  .... . | ..|        . ..
pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekar

SVTQFQITNWDSTGevkNPQTILMIIEEMYRTQRKRGntSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQTV
 ||..   .|   |    | . | |.| . ...  .|   ||||||  .||.         ...  .  .|.   ..|.  | |.  |.|| 
kvthyhwidwpdrg...vpaadlailellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtd

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 685-793 5.4e-11 36.6 In-house 138-242 (244) alignment
Range on Protein: 685-793
Range on HMM: 138-242/244.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQevcyqYWPStSIALVIGEYNIT--LLNENTNNRYIERKFEVKNNNTGVKQSVTQFQITNWD
 .|... |. .|. .||||. .| |  .|.|   .|...     |||  |  |   | .||  | . .        ..|.. .    .|..| |||.|| 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpd.seplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwp

STGEVKNPQTI
| |   |   |
sdgttpndhfi

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 684-789 7e-11 36.5 In-house 28-129 (130) alignment
Range on Protein: 684-789
Range on HMM: 28-129/130.0
KAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQevcyqYWPStSIALVIGEYNITL-LNENTNNRYIER-KFEVKNNNTGVKQSVTQFQITNW
. .. .. |. .|. .||||. .| |  .|.|   .|...     |||  |  |   | .|.. | .  . ..|.  ..|....    .|..| |||.||
aeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpd.sePlewyeediivtltdrdefknikasnleiesdlneshqaltmfqisnw

DSTGEVKN
 | |   |
psdgttpn

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 684-863 1e-09 32.6 In-house 82-263 (312) alignment
Range on Protein: 684-863
Range on HMM: 82-263/312.0
KAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTsIAL-------VIGEYNITL-LNENTNNRYIERKFEVKNNNTGVKQSVTQ
. |.....|. ||. .||..      |.|..||   |.  | | .|     ...       |  ||   . .  .....   | . |  . || .  . .
erfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi.vgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnh

FQITNWDSTGEVKNPQTILMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAA---TTINKCKTEGVIDVFQVLKSQRIQkpgSVQTVV
.| . |   |     .| | ..  .     |. .  .. |||  |||.  ..      ... . . . | |.| .|. .| .   ||... 
yqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrar...svrvfp

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 685-863 1.6e-09 31.6 In-house 91-272 (302) alignment
Range on Protein: 685-863
Range on HMM: 91-272/302.0
AFIIAESPMFNTA---RNFWKMIDDRNVTAIVILCHENENNQeVCYQYWPSTSIALVigEYNITLLNENTNNRYIERK--FEVKNNNTGVKQSV--TQFQ
  |.|  |  ...    .||.|. ..... .|||  |.| ..    ...| .| . .  ||.   .|    ..  | |  . .     |. .||  .   
siilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyk..eygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyv

ITNWDSTGEVKNPQTILMIIEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.||| ..   ..  ..   .....  .   .. ..|.     .|| ..| ..|....| ...    . ...|| | |.| .|... 
ltnWkqkkvpvkyaeliktaakvfa.kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 685-734 3.3e-09 31.0 In-house 77-126 (297) alignment
Range on Protein: 685-734
Range on HMM: 77-126/297.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS
 .|.|. |. .|  .||... ...| .||.... .|. .. |. ||||. 
kyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 682-834 1.8e-08 28.1 In-house 105-290 (349) alignment
Range on Protein: 682-834
Range on HMM: 105-290/349.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-----IALVIGEYNITLLNENTNNRYIERKFEVKNNNT---------
 .| .|    |.  |  .|.|.|   .|  .. | ...|.. | |..||   |     . |     .|. .. |. . . ... . .|.|          
vekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpdd

----G----VKQ--SVTQFQITNWDSTGEVKNPQTILMIIE-------EMYRTQ-R-KRGNTSIVVHCSDTVGRSAMFCAAATTIN
         |..   . |.|. ||  .. . ||..||  .|       ...  .   .   ....||||   ||. ...     ..
ddddaillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls

Herpes_gE Alphaherpesvirus glycoprotein E 552-631 1.5e-06 16.8 Pfam-A 331-404 (439) alignment
Range on Protein: 552-631
Range on HMM: 331-404/439.0
PGTPVMPTTTTSDEG-SMTIVFIAVGAIVCILVLIVIIIIIVVVVVLKKRRGSNDFdinpkntSTSKPEATVYYSTCKSNN
| .. .|..... .. . .   . ..|.....||.......|.|.| |.|| ..         .. .|...|| |  ... 
ppatpapsaepakpeartapyllllaavlgaavlllvvlllvlvcvtkrrrrkaye.......krlspfspvYtsLPtnel

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 798-867 2.4e-06 21.6 In-house 218-286 (297) alignment
Range on Protein: 798-867
Range on HMM: 218-286/297.0
EEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQL
 | .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.   .|
leslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfel

subfamily_eak_pd Subfamily eak 685-786 4.8e-06 20.2 In-house 94-194 (332) alignment
Range on Protein: 685-786
Range on HMM: 94-194/332.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNNRYIERKFEVKNNNTGvkQSVTQFQITNWDS
 .|..  .  .    ||.|. ...  ||| | .. |.. |   .|.|  .   |  | ....  .   .| .  |..|..  |      |  ...  |  
kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnet..hrvlhykvfGwte

TGE
|  
ttl