Gene PTPRD-27 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP081_AA protein Get Run
AqueP081_AA_674-874 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 675-864 1.6e-104 343.9 In-house 77-266 (287) alignment 
Range on Protein: 675-864
Range on HMM: 77-266/287.0
VLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIaLVIGEYNITLLNENTNNRYIERKFEVKNNN-TGVKQSV
| ..||||||||||||||||||||||||.||||||||||.||.|.||..||||||||...  .|.|||||.||||..|. |||||.||||.| .| ||.|
vfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqv

TQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
.|.|||||||||.|..|||||..|||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  
kqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveq
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 666-875 6.2e-100 328.8 In-house 73-286 (290) alignment 
Range on Protein: 666-875
Range on HMM: 73-286/290.0
DMTTEEGCQVLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALvIGEYNITLLNENTNNRYIERKFEVKNN
| | |    . .|||||||..|....|..||...|||.|....||.||.|....|.....|.||||... .  .||..|.||||.| |.|||||.||||.
DCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknk

NT-GVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
|. | ||||||.|||||||||.|.||||||..|||||.||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||..
nsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqq

VQ----LYLAYEDRI
.|    ..| | |..
yqgifqivltyldsf
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 651-863 1.9e-56 186.5 In-house 56-270 (305) alignment 
Range on Protein: 651-863
Range on HMM: 56-270/305.0
TVMKPKKPVIEEFPSDMTTEEGCQVLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIA-LVIGEYNITLLNE
|......  . | .|.  ..      ..|||.||..|.| .|. || ..||..| .  |. ||.|..  |.... |.|||| .      .||....| .|
tlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelkse

NTNNRYIERKFEVKN-NNTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVL
.| . |||||... . ..   ...|.|.|.|.|   | .. . ..| .|... ..|.|  .....||||..|||. .|.|    ....|.|.|.|||.||
ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevl

KSQRIQKPGSVQTVV
|  | .... |||  
kqlRskrmkmvqtld
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 677-868 2e-52 172.7 In-house 78-286 (301) alignment 
Range on Protein: 677-868
Range on HMM: 78-286/301.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYNITLLNEN-----------------TNNRYIER
..||.|||.||.|..|| .| ..||..| .  ...||... ..|. .. |.||||...      |. ..|| ||.                 .|| ||||
idgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyier

KFEVKNNNtgVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGS
||.||...    ..|.|.|.|.|   | |..|.|.|..|...  .|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| 
kfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpga

VQTVV-SVQLY
|.|    ...|
VtTLeqytsiy
0050432 (Phosphotyrosine protein) phosphatases II 677-864 2.4e-50 167.0 In-house 99-287 (308) alignment 
Range on Protein: 677-864
Range on HMM: 99-287/308.0
LKGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST--SIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQS
 .||  | ...||.. .|. ||  .||.|. . ||. || |. . ||..| |.||||..  .  |..| . .|||.| ... |. |..|..|...|    
vdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrt

VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQrkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
||.|. |||   |   .|. .| ..|.. ...   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||.  
vthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq
subfamily_PTPRD_pd Subfamily PTPRD 677-862 3.9e-50 166.0 In-house 84-267 (564) alignment 
Range on Protein: 677-862
Range on HMM: 84-267/564.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSiALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQF
..||...||.| .  |. .| ..||.|. ..|.. ||.| . .|.... | .|||...    .||. .|| .|.. . |. |.|..|....  .. |.||
idgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqF

QITNWDSTGEVKNPQTILMIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. |.| ..|  ......| .|... ... ....  ||||||  |||. .|..    ... |.|...|..|..|  | |..  ||| 
hFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqte
0051299 (Phosphotyrosine protein) phosphatases II 677-863 5.5e-50 165.8 In-house 85-273 (288) alignment 
Range on Protein: 677-863
Range on HMM: 85-273/288.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNN----NTGVKQS
..||. |..||... |. ||  .||.|. . ||. ||.|. . |...| |.||||. .  |..|.. .|||.| ... |. |..||.|.     .| .. 
idgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrt

VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
||.|. |||   |   .|. .| ....... ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||. 
vthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 677-863 8.2e-50 165.1 In-house 65-261 (284) alignment 
Range on Protein: 677-863
Range on HMM: 65-261/284.0
LKGY-----KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVKNNN-TGVK
..||     . ||.||..  |. ||  .||.|. . ||. || |. . ||..| |.||||...  |..|.. .|||.|.... |. |..|..|.. ||  
vdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytges

QSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVV
  ||.|..|.|   |   .|. .| ..... . ...  |.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||. 
rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
0036941 (Phosphotyrosine protein) phosphatases II 677-863 8.4e-50 165.1 In-house 71-264 (297) alignment 
Range on Protein: 677-863
Range on HMM: 71-264/297.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST-SIALVIGEYNITLLNENT--NNRYIERKFEVKNNNTGVKQSV
..||. |..||... |. ||  .||.|. . ||| || |. . |.. | |.||||..    |. |.. .|||....  .. |. |..||.....| .  |
vdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtv

TQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVV
|.|..|.|.  |   .|...| .||.. . ...  ... ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||. 
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle
0047943 (Phosphotyrosine protein) phosphatases II 677-862 1.4e-49 164.4 In-house 70-258 (273) alignment 
Range on Protein: 677-862
Range on HMM: 70-258/273.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI--ALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVT
..||. |..||... |. ||  .||.|. . ||. || |. . |...| |.||||..     |. |.. .|||.|.|.. |. |..|..|..|| .  ||
vdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvt

QFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|. |.|   |   ... .| .||.. .....  .|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||.
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp
0045450 (Phosphotyrosine protein) phosphatases II 675-862 7.7e-49 162.4 In-house 72-290 (307) alignment 
Range on Protein: 675-862
Range on HMM: 72-290/307.0
V--------------------------LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLN
|                          ||.||. |..||.. .|. .|  .||.|. . .||.|| |... |...| |.||||...  |..|.. .|||.
VklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtlls

ENTNNRYIERKFEVKNN-NTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---ID
|.. . |. |..||...  ||    ||.|. |.|  .|  ......| .|||. . ...  ... ..||||. |||...|.|| . .   ..||.   .|
eehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd

VFQVLKSQRIQKPGSVQTV
.....|  | |.||.||. 
lleavkllreqRpgavqnp
0040438 (Phosphotyrosine protein) phosphatases II 677-872 8.4e-49 161.9 In-house 62-273 (317) alignment 
Range on Protein: 677-872
Range on HMM: 62-273/317.0
L-----------------KGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERK
|                 .|...|..||.. .|. ||  .||.|. . .|| || |... |...| |.||||.    |..|.. .|||.| ... .. |.
LsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrt

FEVKNNNTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSV
.||...... .  ||.|. |.|.  |  ..|...| ..|.. . .. .... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.|
levedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgav

QTVVS-VQLYLAYE
||    ..|| |  
qtpeqyrflydall
Y_phosphatase Protein-tyrosine phosphatase 677-862 1.1e-47 157.8 Pfam-A 35-223 (235) alignment 
Range on Protein: 677-862
Range on HMM: 35-223/235.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWP-STSIALVIGEYNITLL-NEN-TNNRYIERKFEVKNNNTG-VKQS
.|||||||.||... |. .|   ||.|. ...|..||.|....|...| | |||| ...  |  |.....|  .|.  ...|. ||.|.|....   |..
vkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekre

VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
vkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
Y_phosphatase Protein-tyrosine phosphatase 677-862 1.1e-47 157.8 In-house 35-223 (235) alignment 
Range on Protein: 677-862
Range on HMM: 35-223/235.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWP-STSIALVIGEYNITLL-NEN-TNNRYIERKFEVKNNNTG-VKQS
.|||||||.||... |. .|   ||.|. ...|..||.|....|...| | |||| ...  |  |.....|  .|.  ...|. ||.|.|....   |..
vkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekre

VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|...|||   |  ..|. .| .|... ... .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
vkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 678-863 8.7e-47 154.3 In-house 69-253 (283) alignment 
Range on Protein: 678-863
Range on HMM: 69-253/283.0
KGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSiALVIGEYNITLLNENTNNRYIERKFEVKNN-NTGVKQSVTQF
| ||..| .||| ||. .| ..||||. |...||||.| .  |.... | ||||.   .   ||. .|| .| |.| .| ... ...|  .  .  .. .
ksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahy

QITNWDSTGEVKnPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|. .| . ||   .   |. .. .   |..  .. |||||| ..||.|.|.||...... .|| |.|||.|.|  | |... |||  
qvidWleygeqa.iinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtld
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 676-862 4.6e-46 152.4 In-house 91-276 (298) alignment 
Range on Protein: 676-862
Range on HMM: 91-276/298.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAlVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQ
 |..||...|||... |. .|  .||.|. ......||.|   .| ..  . .|||..  .   || ...||....   .| ||..|.....  ...| |
flhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkeekerevrq

FQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. |.| . |. .| ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| 
lhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte
DSPc_SM00195 677-862 7.9e-46 151.9 In-house 62-248 (263) alignment 
Range on Protein: 677-862
Range on HMM: 62-248/263.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNN-RYIERKFEVKNNNTGVKQSVT
.||...||..|..  |. .| . ||.|. ...|. ||.|. |.||..| |..|||..|    ..|.....| .... .  .| |..|......  ...||
ikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvt

QFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|..||   |  .... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
qyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
PTPc_SM00194 677-862 7.9e-46 151.9 In-house 62-248 (263) alignment 
Range on Protein: 677-862
Range on HMM: 62-248/263.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNN-RYIERKFEVKNNNTGVKQSVT
.||...||..|..  |. .| . ||.|. ...|. ||.|. |.||..| |..|||..|    ..|.....| .... .  .| |..|......  ...||
ikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvt

QFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|..||   |  .... .| ...... ....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.||| 
qyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 677-884 1e-45 151.2 In-house 82-289 (318) alignment 
Range on Protein: 677-884
Range on HMM: 82-289/318.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSiALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQF
. ||..|||.| | .|. .| ..||.|. ..| . ||.| .|.|. .. . .||||   .  .|.  ..| .| . . |. |.|.|.....  .. | |.
idGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqy

QITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ-LYLAYEDRI
..|.|  .|  ... ..| .. .  ..|.| |.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  |||    . .| .  . .
hytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal

MSDYSMIHA
.|  . ..|
asgdtevda
0039614 (Phosphotyrosine protein) phosphatases II 676-862 2.3e-45 150.7 In-house 74-275 (297) alignment 
Range on Protein: 676-862
Range on HMM: 74-275/297.0
LL------------------KGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQeVCYQYWPSTSIalVIGEYNITLLNENTNNRYI
 |                  .||.  ...||..  |. .|  .||.|. . .||.|| |. ..|...  |.||||...   . |.. .|||.. ... |.
klkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgyt

ERKFEVKNnnTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQK
 |..||.|  .|    ||.|| |.|   |   .....| ..|.. . ...  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.
vrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR

PGSVQTV
||.||| 
pgavqtp
0043336 (Phosphotyrosine protein) phosphatases II 677-862 6e-45 149.2 In-house 81-263 (278) alignment 
Range on Protein: 677-862
Range on HMM: 81-263/278.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPstSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQF
..||. ...||..  |. .|  .||.|. . .|| || |. . |.... |.||||  .  |..|.. .|||.|.... |. |..||.|. .| .. ||..
vdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthy

QITNWDSTGEVKNPQTILMIIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. ..|   |   .....| ..... . ..   |. ..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.||| 
hylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp
0042113 (Phosphotyrosine protein) phosphatases II 678-862 3e-44 146.7 In-house 46-229 (245) alignment 
Range on Protein: 678-862
Range on HMM: 46-229/245.0
KGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQ
.||. .. ||..  |. .|  .||.|. . ..|.|| |. | |.... |.||||. .  |..|.. .|||.|.... |. |..||.|. .. .. |....
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

ITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 ..|.  |.  .....| ..|.. . ... .|. ..||||. |||...|.|| . ..  ..|. .......|  | |.||.||| 
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtp
0040439 (Phosphotyrosine protein) phosphatases II 677-862 3.2e-43 143.5 In-house 47-232 (249) alignment 
Range on Protein: 677-862
Range on HMM: 47-232/249.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQF
..||. |..||..  |. .|  .||.|. . ..|.|| |... |...| |.||||. .  |..|.. .|||...... |. |..|..|. .| .  |...
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

QITNWDSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.|.|  .|  ......| .||..   ...   .. ..||||. |||...|.|| . ..  ..|. .|.....|  | |.||.||. 
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp
0045098 (Phosphotyrosine protein) phosphatases II 677-862 4.6e-43 143.0 In-house 59-258 (278) alignment 
Range on Protein: 677-862
Range on HMM: 59-258/278.0
LKGYkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNN----NTGVKQS
..||  .|.||..  |. .|. .||.|. . ..|.|| |... |...| |.||||. .  |..|.. .|||.| ... |. |...| |     ... .  
idgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrg

VTQFQITNWDSTGEVKNP--QTILMIIEEMYRTQR------------KRGNTSIVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-
||......|.  |   .|  . .| ..|.. . ..              ... ..||||  |||.....|| . .  .  ||..|.....|  | |.|| 
vthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpgl

SVQTV
.||. 
avqnl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 675-862 8.4e-42 138.1 In-house 43-228 (250) alignment 
Range on Protein: 675-862
Range on HMM: 43-228/250.0
VLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEvCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVT
. |.||.|.||||.. .|. .|  .||.|. ......||.|   .|.... . ||||    |   |.  ..||....   |. ||. . ...   .. | 
sflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.ekaekyGdvtvsllskeefadytkrklklskakkaderivr

QFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
|.. ..|   |  .. ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |.| |.|||.|.|  |...|..|.. 
qlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 676-863 1.6e-41 137.4 In-house 83-270 (319) alignment 
Range on Protein: 676-863
Range on HMM: 83-270/319.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIaLVIGEYNITLLNENTNNRYIERKFEVKNNNTGV-KQSVT
 . ||.|...|| . .|. ||  .||.|. ....  .|.|.. .|. .  . .|||.. .  . |.. .||..|.  . || ||........ |   .|.
fidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenf.eeyGrlivtleeeeeledyiirklklnkkssevetRevk

QFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.|| |.|   .  .. ...| ..... ....|  .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||.  
hfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpe
subfamily_PTPRA_pd Subfamily PTPRA 677-866 5.5e-41 135.5 In-house 94-285 (330) alignment 
Range on Protein: 677-866
Range on HMM: 94-285/330.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIaLVIGEYNITLLNENTNNRYIERKFEVKNNNTG----VKQS
..|||||. || |  |  .|  .||.|| ... ..||.| . .| ..| |.||||.  . .  |. .... .|.  . |  ||| |.. . .     .. 
idGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrl

VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNtSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
|.||  | |   |   .|. .| ..... ..... .. .||||||  |||.  |..  . ... |.|...|||...|. | |.|  |||    .
vrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqye
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 677-875 4.9e-40 132.4 In-house 77-276 (281) alignment 
Range on Protein: 677-875
Range on HMM: 77-276/281.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVkNNNTGVKQSVTQF
..|||..|..|....|. ..  .||.|. ...|.|||.. .| |...  |..|||  . .| .|.. .. ..|.....||||||.. ....| ...|.|.
vpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveql

QITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVS-VQLYLAYEDR
. |.|  .|  .... .|   .|......|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||||    .|.|  | 
aytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda

I
.
l
subfamily_Ptp69D_pd Subfamily Ptp69D 677-881 1.3e-39 131.1 In-house 84-287 (307) alignment 
Range on Protein: 677-881
Range on HMM: 84-287/307.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTsIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGV-----KQ
.||||||| ||.|  |. .|. .||.|| . .|| ||.|  ..| |.. | .|||        |. ...| .|.. . ||.|...| ...  .     ..
ikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsr

SVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVsvQLYLAY
 |.|.. |.|. .   . ....| .||...  ...  .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  ||     |    |
kvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsle..qYvfly

edRIMSDYSM
  | . |||.
..ralldyss
0037934 (Phosphotyrosine protein) phosphatases II 684-862 5.6e-38 126.3 In-house 45-228 (243) alignment 
Range on Protein: 684-862
Range on HMM: 45-228/243.0
KaFIIAESPMFNTARN----FWKMIDDRNVTAIVILCHENENNQEVCYQYWPsTSIalVIGEYNITLLNENTNNRYIERKFEVKNNN-TGVKQSVTQFQI
. .|.   |. .|  .    ||.|. . ..|.|| |... |...| |.||||  ..  ..|.. .|||.|.. . |. |.....| . ..... |.... 
r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhy

TNWDSTGEVKNPQTILMIIEEMYRTQRK-------RGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTV
..|   |   .|. .| ...|..  ...        ..  ..||||  |||.....|| . . ..   | .|.....|  | |.|| .||| 
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtp
subfamily_PTPRK_pd Subfamily PTPRK 676-862 3.9e-37 122.8 In-house 78-263 (314) alignment 
Range on Protein: 676-862
Range on HMM: 78-263/314.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAlvIGEYNITLLNENTNNRYIERKFEVKNNN--TGVKQSV
|. .||  .|||..  |. .| ..||... | | ..||.| .  |. .  |..|||  .     |. ...|.. .... .. | | |.. .     .. |
lidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirev

TQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 ||| ..| . .  .. ...| .. ..  .| . ..  ||||||   ||. .|.| .. ..  ..|||.|||.. |. | .|.  |.| 
rqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvete
subfamily_PTPN12_pd Subfamily PTPN12 676-863 1.2e-36 121.1 In-house 75-264 (290) alignment 
Range on Protein: 676-863
Range on HMM: 75-264/290.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNN-RYIERKFEVKNNntGVKQSV
..|| ..|...| | .|. .|  .||.||.. ||. .|..|.| |...  | .|||..   .| .||...|| .|.. .  .. | ..|...  . ...|
fikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkv

TQFQITNWDSTGEVKNPQTILMIIEEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVV
.||. |.|   |  ......| .||.. ..|. . .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  |||  
yqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtke
subfamily_PTPRB_pd Subfamily PTPRB 677-863 1.3e-36 121.1 In-house 87-272 (293) alignment 
Range on Protein: 677-863
Range on HMM: 87-272/293.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVKNnnTGVKQSVTQF
..||. .. || .  |. .|  .||.|. ......||.| .  |. .. | .|||... . . |. ..||..|.. . .. |......  .  ...|.|.
ipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqy

QITNWDSTGEVKNPQTILMIIEEMYRTQ-RKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
. | |   |  ....|.| ..... ... ..  .. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||. 
hftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtek
subfamily_PTPRG_pd Subfamily PTPRG 677-884 2.4e-35 116.8 In-house 84-296 (563) alignment 
Range on Protein: 677-884
Range on HMM: 84-296/563.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTG------VK
..||. .||||..  |. .|.  ||.|| ..||. ||..   .|.... | .|||.   .. .|. ..|| .|..   | .|.. .|| .         .
idGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdte

QSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS-VQLYL
. |.|.. |.|  .|  . .   |. ..   .....     ||||||  |||. ....  | ... ..| ...||..||  | |..  |||    . |. 
klvrqyhytkWPdhgvPehslpvLifvkkssaanka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhd

AYEDRIMSDYSMIHA
|  . |.|    . |
alleaiasketella
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 657-885 2.5e-35 117.1 In-house 64-298 (325) alignment 
Range on Protein: 657-885
Range on HMM: 64-298/325.0
KPVIEEFPSDMTTEEGCQVLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNvTAIVILCHENENNQEVCYQYWPST-SIALVIGEYNITLLNENTNNRY
..|.|    |  ..      |. .|.|. |. | .|. .|  ..|... | . ...|..  | ..... | .|||   . .   |  .. |   ..   |
rvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdy

IERKFEVKNNNTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEM---YRTQR--KRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKS
. |...||. . |  .|| |||.  ||  |  | | |.. |.. .     . .   .. | |.||||. |||. .| .  . ..|  .|  .|.|...| 
vhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkk

QRIQKPGSVQTVVSVQ-LYLAYEDRIMSDYSMIHAS
 | ..|  |.||     .| |  . .||  . .  |
lrkdrpsmvetvdqyiliyealveaymsgntdvpvs
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 677-873 3.2e-35 116.5 In-house 80-275 (315) alignment 
Range on Protein: 677-873
Range on HMM: 80-275/315.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPS-TSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTgvKQSVTQ
.|.... ||.| .  |   .  .||.|. . .||.||.. . .|...  | ||||   . .   |.....||. ...   . ||. ... ..  .. |||
iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee..srtvtq

FQITNWDSTGEVKNPQTILMIIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSV-QLYLAYED
|| |.|   |  |.  ..| .| |.    ... . |..||||  |||. .....   ... | . ..|||...|  | ..|  |||      .| |  .
fqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 683-887 3.6e-35 116.5 In-house 91-296 (297) alignment 
Range on Protein: 683-887
Range on HMM: 91-296/297.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQeVCYQYWPSTSIALvIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQITNWD
|. .|  . || .|  .||.|. | .|..||.| ..||...  | .||. ....   |.  ..||  .  . .|.|..||..... ... | |.| ..| 
khrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWP

STGEVK--NPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ-LYLAYEDRIMSDY
.  . .  . ...| .|.|.  .  .. .. ..|||.  ||| .....    . . | |  .|.|...|  | ..|  |||    . .| |  . ..|. 
dkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed

SMIHASQF
  |.|| |
triqasyf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 677-899 2.4e-34 114.2 In-house 61-282 (284) alignment 
Range on Protein: 677-899
Range on HMM: 61-282/284.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILChenennQEVCYQYWPSTsIALVIGEYNITLLNENTNNRYIERKFEVKN-NNTGVKQSVTQ
..||. |. .| .  |. ||  .||.|| . |...||.|       .. | ||||   |    ..... .   .  . |. |..|. .  .   .....|
itGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk.ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirq

FQITNWDSTGEVKNPQTILMIIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ-LYLAYED
| .  |   |  . |  ......   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  . .| |  .
fhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

-RI--MSDYSMIHASQFYDTDQNNDSIND
 ..   || ..     ...   |.  ..|
ehlfghsdvalpdfpayleelsnksdfdd
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 677-894 2.4e-34 114.1 In-house 97-313 (319) alignment 
Range on Protein: 677-894
Range on HMM: 97-313/319.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILChenennQEVCYQYWPSTsIALVIGEYNITLLNENTNNRYIERKFEVKN-NNTGVKQSVTQ
..||. |. .| |  |. ||  .||.|| . |...||.|       .. | ||||   |    ..... .   .  . |. |..|. .  .   ....||
vtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplk.ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitq

FQITNWDSTGEVKNPQTILMIIEE-MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ-LYLAYED
| .  |   |  . |  ......   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|  . .| |  .
fhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

-RI--MSDYSMIHASQFYDTDQNN
 ..   || .|     ...   |.
ehlfghsdvampdfpayleelsnk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 677-863 3.4e-34 113.2 In-house 83-266 (288) alignment 
Range on Protein: 677-863
Range on HMM: 83-266/288.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVKnnNTGVKQSVTQF
..|.|.||..| . .|. .|  .||... ..... || | .  |.... | .|||..      |. ..||..... . ...||....   .. .  .||.
idgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqy

QITNWDSTGEVKNPQTILMIIEEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
| . |  .|  .. . .| ... .  .. .     |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||. 
qylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlk
subfamily_PTPN23_pd Subfamily PTPN23 685-866 4.5e-34 112.6 In-house 84-270 (288) alignment 
Range on Protein: 685-866
Range on HMM: 84-270/288.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQITNWDS
 ||.. .|. .|.  ||.|. .. .  ||.| ...| ... . .|||.    . . |....|| .... . ..||..... ...  ..||.  |.|.| .
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpe

TGEVKNPQTILMIIEE---MYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
 |  . |.|.| ...|   .|...... .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||..  ..
lGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk
subfamily_PTPN6_pd Subfamily PTPN6 682-866 7.6e-34 112.1 In-house 96-287 (306) alignment 
Range on Protein: 682-866
Range on HMM: 96-287/306.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVK-NNNTGVKQSVTQFQITN
..|..| ..  . .|  .||.|. . | . ||.. .|.| ..| |..|||...     |....| ..|.....|| |.. |. ... . ...| |.. ..
sdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfks

WDSTGEVKNPQTILMIIEEMYRTQRKRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVVSVQ
|   |  |.|...|  .|.. | |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | |||    .
WPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqyk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 676-866 1.4e-33 111.2 In-house 84-269 (315) alignment 
Range on Protein: 676-866
Range on HMM: 84-269/315.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTsiALVIGEYNITLLNENTNNRYIERKFEVKNNNTgVkQSVTQ
...||. |. .| |..|  .. ..||... . ... ||.|    |.... . .|||     .. |.. .|. .|. |..|  | . |  ..  . . | |
fidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdn.i.revvq

FQITNWDsTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
...| |  . .| .  . || .    .  ..   ..||||||. |||.  |..  . ... ..| .|||.....  | .. . ||..   |
lhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 677-864 2.1e-33 110.2 In-house 79-264 (515) alignment 
Range on Protein: 677-864
Range on HMM: 79-264/515.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPS-TSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTgvKQSVTQ
.....  ||.| .  |   .  .||... . |||.|... . .|...  | .|||   . ..  |.... |.  ..    | ||..|  ..    . |||
ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtq

FQITNWDSTGEVKNPQTILMIIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
|. |.|   |  |. ...| .| |. .... . . ....|||  |||  .....   . . ||  ..|||....  | ..|  |||   
fhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeq
subfamily_PTPN3_pd Subfamily PTPN3 684-863 1.1e-32 108.1 In-house 84-262 (280) alignment 
Range on Protein: 684-863
Range on HMM: 84-262/280.0
KAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQITNWDS
. .|..  |. .|| .||.|. ..... ||.|    |. .  |.||||.|.  |  ||..... .|.... |. |.. .|...|  .....|.| ..|  
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpd

TGEVKNPQTILMIIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 |  .... .| ..|.. |..|.  .. .|||||  .||. .. .  |.. .  ..  . . ....  | |.   |||. 
hgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtas
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 676-863 2.3e-32 107.2 In-house 64-255 (274) alignment 
Range on Protein: 676-863
Range on HMM: 64-255/274.0
LLKGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIG---EYNITLLNENTNNRYIERKFEVKNNNTgvKQ
 .|||.| .||.. .  |. ||  .||.||  ..|. ||.| . .|.|.. | .|.| .  . . .   . .|.  . ...| |  ||. .|. .   ..
yikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..er

SVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNT--SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
||. .  |.|  .   ....|.| ...|. ...... .   ..|||||  .||  .| |.  .... . |.|.||...    |... | |||  
svkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtse
subfamily_PTPN9_pd Subfamily PTPN9 677-861 1.9e-31 104.2 In-house 78-275 (297) alignment 
Range on Protein: 677-861
Range on HMM: 78-275/297.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWP-STSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQ
. |||.||||| .  |. .| ..||.|. ...|  ||.  .  |. .  | |||| ..  .   |..... .. .... | .|..|.|| .|. ...|| 
vdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvth

FQITNWDSTGEVKNPQTILMIIEEMYRTQR---------KRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
||.. |   |  .. ...| ..|.. ..|          ..|   .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.||
fqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqt
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 677-873 8.3e-31 101.8 In-house 73-272 (287) alignment 
Range on Protein: 677-873
Range on HMM: 73-272/287.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNE-NTNNRYIERKFEVKNNNTGVKQSVTQ
. .|....||| | .|.  | |.||... .......... .| |. .  ||.|||     . .| | ..||.  . .  |  | . . . .|   . | |
vasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkq

FQITNWdsTGEVKNPQ---TILMIIEE--MYRTQRK-RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVsvQLYL
... .|    .|  |     | ....       .|.  .   .|||..  .||| .. |  . ... .  | .|| .|.   | .. . ||.||  || |
ldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavv..qlrl

AYED
 || 
lyea
subfamily_PTPN1_pd Subfamily PTPN1 680-872 3.8e-30 99.6 In-house 67-265 (290) alignment 
Range on Protein: 680-872
Range on HMM: 67-265/290.0
YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI--ALVIG--EYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQ
 . |. .|..  |. ||.  ||.|. ...  |.|.| .  |..|  |.||||.     .|..   .....|..|.... |. |..|..| .|   .....
eeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilh

FQITNWDSTGEVKNPQTILMIIEEMYRTQR-KRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVVsvQLYLAY
|  | |   |  . |.. |  . .. ..   ..     |.|||  .|||  || . | .    | .    .|. .||   | .. | .||    || ..|
fhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtad..qlrfsy

E
 
l
subfamily_CG7180_pd Subfamily CG7180 658-863 1.1e-28 94.8 In-house 59-277 (296) alignment 
Range on Protein: 658-863
Range on HMM: 59-277/296.0
PVIEEFPSDMTTEEGCQVLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQeVCYQYWPSTSiALVIGEYNITLLNENTNNRYIE
.|.|..  . ...    |   ..  ||..|. | |. .|  .||... |... |.|.|... . ..  . .||| .|     ||  . ...|..      
vvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlki

RKFEVKNN-------NTGVKQ---SVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRG-----NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVI
|.| .. .       ...||     |..||.| |..  .|    . |. . .. |. |..      .  .||..|| ..|| ...|.  .... . |. .
rtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeev

DVFQVLKSQRIQKPGSVQTVV
|||. .|  |...|. |..| 
dvFeavktlrrsRpqLvenve
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 678-867 1.1e-28 95.1 In-house 57-255 (270) alignment 
Range on Protein: 678-867
Range on HMM: 57-255/270.0
KGYK-EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS---IALVIGEYNITLLNENTNNRYIERKFEVKnnNTGVKQSV
.|.. |||..| | .|. .| ..||.|| ...|||||.. . .|.... | .|||. .   ..|  |. ... |.|. .. || .. ...  ..| .. .
rGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrl

TQFQITNWDSTGEVKNP------QTILMIIEEMYRTQRKRGN-TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
. |. ..|   | ....      . .| ..... |....  . . ..||||. |||. .. |  ....  .... .|| ....  | ...  ||... ..
vHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqye

L
.
f
subfamily_PTPN13_pd Subfamily PTPN13 681-862 3e-28 93.9 In-house 74-255 (273) alignment 
Range on Protein: 681-862
Range on HMM: 74-255/273.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIA--LVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQI
|..  .|..  |. .|...||.|. ..... |... .| |...  | .|||..      | . ....||. .  . .  |...||....|  . |.... 
kdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnf

TNWDSTGEVKNPQTILMIIEEMYRTQRkrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
..|   |  .... .| .. |. | |.   .. ||||||  .||| .. .  . ..  . .  .|| ..... | |. | ||| 
vkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 676-862 5.5e-28 92.7 In-house 64-245 (267) alignment 
Range on Protein: 676-862
Range on HMM: 64-245/267.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNqeVCyQYWPST-SIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVkQSVT
 ..||| |.|||. . |. ||  .|...| |..|. ||.| .  ..|  .  ..||     |    .  .    |. .| |    .|.| .|    . ||
yvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn..ir.lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa.hnvt

QFQITNWDSTGEVKNPQTILmiIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .   .|.   . |     |  .  . . | . ||  .||.||| ||||  |  . . ... ||||| |.|. |.  | |..| |.| 
lyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk
subfamily_PTPRN_pd Subfamily PTPRN 683-867 1e-27 91.7 In-house 99-283 (297) alignment 
Range on Protein: 683-867
Range on HMM: 99-283/297.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAlVIGEYNITLLNENT-NNRYIERKFEVKNNNTGVKQSVTQFQITNW
. |.| ...|. .|  .||.|. .. |. || |.. .|.. . |..||| .  . | . |.. |. |    . |. | | .|| .|   ..||||    |
apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflsw

DSTGEVKNPQTILMIIEEMYRTQRKRGnTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVSVQL
 ..|   .....|     . .. | |  ..||||||| .||. ....    .|.  |    ||.   |.  | |.|| |.|    ..
peegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef
0036282 (Phosphotyrosine protein) phosphatases II 678-861 2.8e-26 87.7 In-house 11-155 (174) alignment 
Range on Protein: 678-861
Range on HMM: 11-155/174.0
KGYKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStsialvigeynitllnentnnryierkfevknNNTGVKQSVTQFQ
...   . .|.   |.      ||.|. . ..|..| |..|.|.. . |..|||.                                . .  .... |..
dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lredlerlgiqyl

ITNWDSTGEVKNPQtILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQT
 ..|.  |.   .. .| ....... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||
ylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
0051429 (Phosphotyrosine protein) phosphatases II 679-871 1e-25 86.3 In-house 14-220 (272) alignment 
Range on Protein: 679-871
Range on HMM: 14-220/272.0
GYKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVILCHENENNQEVCYQYWP-----------STSIALVIGEYNITLLNENTNNRYIERKFEVKN
||     ..... .  |. .||..||..  . ....|| |..|.| ... |..|||           ..     .| . .||| | . . || |......
gygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltl

N-NTGVKQSVTQFQITNWDSTGEVKNPqtILMIIEEMYRtqrkrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------VFQVLKSQRIQK
  ..|    |.... |.|   |  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        ......  | | 
llsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqr

PGSVQTVVSVQLYLAY
||.|||   ..  . .
pgavqteeqylflyea
subfamily_PTPN14_pd Subfamily PTPN14 682-863 6.1e-25 82.8 In-house 91-283 (300) alignment 
Range on Protein: 682-863
Range on HMM: 91-283/300.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST---SIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQSVTQFQI
... .|.| .|. .| ..||.|. . .|. ||.| .|.|. .| ...|.|..      .  |....|    .. ...| .....|   .. ...|  .| 
kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy

TNWDSTGEVKNPQTILMIIEEMYRTQRKRGNT--------SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
|.|   |  ..... |  .||.   .||  ..         ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. 
tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtla
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 683-868 1.3e-24 81.4 In-house 89-271 (301) alignment 
Range on Protein: 683-868
Range on HMM: 89-271/301.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST-SIALVIGEYNITLLNENT--NNRYIERKFEVKNNNTGV-KQSVTQFQI
 . ||.. .|. ||. .|| |.   .|  ||.|... |...|.| .| |.. |  | || ..|.. |...  |.. ..|..||..    .  ..|| .| 
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqy

TNWDSTGEvknPQTILMIIEEMYRTqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVvsVQLY
..|   |    |..   . . |     |. .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||.   |||
sewtdrgv...Pkshaelfdlmelv..kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn..sqly
0049260 (Phosphotyrosine protein) phosphatases II 677-872 1.4e-23 78.7 In-house 2-146 (152) alignment 
Range on Protein: 677-872
Range on HMM: 2-146/152.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWpstsialvigeynitllnentnnryierkfevknnntgvkqsvtQF
..||. ...||... |. ||. .||.|. . ..|.|| |. . |.. . |.||.                                            |.
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qy

QITNWDSTGEVKNPQTILMIIEEMYRTqRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVVSVQLYLAYE
. ..|.  |  ...| .|.... . .  ... .  ..||||  |||.....||   .        ........  | ..||.|..    .. . .|
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflyefe
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 683-862 5.6e-23 76.4 In-house 44-225 (237) alignment 
Range on Protein: 683-862
Range on HMM: 44-225/237.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFEVKNNNTGVK-QSVTQFQITNW
 | .| |. |. ..  .||.|. . . . ||.|    |.|.. |..|||||      | . ..|  ..    |  | . . .. |  . . . |.|.| |
pkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftsw

DSTGEVKNPQTILMIIEEMYRTQRKR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
   |  ..  ..| .  ..    ..    .  ..|||  |||...|    . . ..| . |.|... ..|   ..|  .|| 
pdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtk
0041856 (Phosphotyrosine protein) phosphatases II 677-862 1.5e-22 75.5 In-house 27-157 (182) alignment 
Range on Protein: 677-862
Range on HMM: 27-157/182.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILChenennqevCYQYWPstsialvigeynitllnentnnryierkfevknnnTGVKQSVTQF
. |.   . ||..  |. .|  .|..|. ....|.|| |.         ...|||                                   . ... ..|.
ylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...................................ellerlgiqy

QITNWDSTGEVKnPQTILMIIEEMYRtqrkrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDVFQVLKSQRIQKPGSVQTV
. ..|.  |    ....| .|||...      .  ..||||  |||.....||   . .    | .......|  | ..||.|.| 
lylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitp
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 683-863 1.9e-22 74.3 In-house 93-270 (290) alignment 
Range on Protein: 683-863
Range on HMM: 93-270/290.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTN-NRYIERKFEVKNNNTGVKQSVTQFQITN
|  ||... .. .|. ..|.|. . .|.|||.||   |. .  | ||.| ..  .| .||. ..  .|... .. | . . |.. ..| .  .  ..|  
kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkiks

WDSTGeVknPQTILMIIEeMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTVV
|     |  ... | ..  . |. ||  .  .|||||  .||.  | |  ... .. ..|  .|. .. .. |  . .|||  .
wpdks.v..alstlallr.tlrilrka.sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdi
0043147 (Phosphotyrosine protein) phosphatases II 677-874 3.6e-21 71.1 In-house 13-159 (172) alignment 
Range on Protein: 677-874
Range on HMM: 13-159/172.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHEnennqevcyqywpstsialvigeynitllnentnnryierkfevKNNNTGVKQSVTQF
|..|   . ||.   |. ||   ||.|. ....|.|| |. .                                             .. ....... |.
ldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpellerlgiqy

QITNWDSTGEVkNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVVSVQLYLAYEDR
. ..|.  |   ... .| ..| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||.    .. . .|..
lylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyfekl
0046846 (Phosphotyrosine protein) phosphatases II 685-862 1.9e-20 68.8 In-house 24-159 (176) alignment 
Range on Protein: 685-862
Range on HMM: 24-159/176.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPStsialvI----GeynitllnentnnryierkfevknnntgvkqsvtQFQITN
..|.   |. .|  .|..|. . ..||.| |. | | ..  |..|||       .                                       |.. ..
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe......leklgi..................................qylhlp

WDSTGEVKNpQTILMIIEEMYRTQRKRgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTV
|.  |     . .| ..|.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.||| 
wpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 673-862 9.5e-20 65.8 In-house 39-226 (239) alignment 
Range on Protein: 673-862
Range on HMM: 39-226/239.0
CQVLLKGYK-EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAlvIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQ
    |. |    ||.| ..  .  .. .||.|. .     ||.|    |  .. |.|||| ..      .  .|| . .    || | | . .     ..
nasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..ycnlrvtlrktevfadyiirtfvmsqvgqteer

SVTQFQITNWDSTGEVKNPQTILMIIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 | |...| |   |  .   ..| .  ..   .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
yvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 673-862 1e-19 65.6 In-house 40-227 (239) alignment 
Range on Protein: 673-862
Range on HMM: 40-227/239.0
CQVLLKGYK-EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAlvIGEYNITLLNENTNNRYIERKFEVKNNNTGVKQ
    |. |    ||.| ..  .  .. .||.|. .     ||.|    |  .. |.|||| ..      .  .|| . .    || | | . .     ..
nasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..ycnlrvtlrktevfadyiirtfvmsqvgqteer

SVTQFQITNWDSTGEVKNPQTILMIIEEMyRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 | |...| |   |  .   ..| .  ..   .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
yvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 676-864 3e-19 63.8 In-house 83-267 (439) alignment 
Range on Protein: 676-864
Range on HMM: 83-267/439.0
LLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENEnnqevCYQYWPSTSiALVIGEYNITLLNENTNNRYIERKFEVKNNN--TGVKQSV
 .||| ..| .| .. |  .|. .||... ..... || |.   |      |.|||| .   . |.  .    .    .|. | | | |.   |  ...|
yikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve.....sykywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertv

TQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
 ||. . |       .   .|  .  .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||... 
lqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcq
PTPc_DSPc_SM00012 773-864 5.5e-19 63.7 In-house 2-95 (105) alignment 
Range on Protein: 773-864
Range on HMM: 2-95/105.0
VTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVS
|.....|.|  .|  .... || ..... . ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.|||   
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeq
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 677-871 1.3e-18 61.6 In-house 81-232 (392) alignment 
Range on Protein: 677-871
Range on HMM: 81-232/392.0
LKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNqevcyqywpstsialvigeynitllnentnnryierkfevknnNTGVKQSVTQF
..... .||.| ...|   .  .||.|. . |||.|... . .| .                                           .   ...|.||
ipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqf

QITNWDSTGEVKNPQTILMIIEEMyrtQRKRGNTS--IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSV-QLYLAY
..|.|   .  |   ..| .|.|.   . . |. .  ...|||  |||...  .  . . ..|.  ..|||...   | ..|  |||      .| | 
hftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 682-883 1.1e-17 59.0 In-house 80-280 (307) alignment 
Range on Protein: 682-883
Range on HMM: 80-280/307.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNNRYIERK---FE---VKNNNTGVKQSVT
. | || |. |. ||  .|| |. . .| ....||.  |  .  | ||||      || || . |.  .|   . .       .   .| . ..  ....
kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiq

QFQITNWDSTGevkNPQTILMIIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVVSvqlYLaYED
..| .||   |    ||. |  |. .  .. .  .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..|| .    || |  
hlqwenwpdrg...vpqinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaq...yl.ylh

RIMSDYSMIH
|.. .| .  
rvlleyflel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 683-864 3.1e-17 57.2 In-house 80-257 (281) alignment 
Range on Protein: 683-864
Range on HMM: 80-257/281.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNNRYIERKFEVKnnNTGVKQSVTQFQITNW
|. .|... |  .|  .||.|| . | ||||.||.  | |.| | .|.|  .  .| . .. ..  .   |.  .  ....     |  . .|..   .|
krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls..yegetrlithwlwkew

DSTgEVKNPQTILMiieEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG-VIDVFQVLKSQRIQ-KPGSVQTVVS
    .| .   ...   .. |  | |  |  |.|||  ||||  . |   ...  ..   . |. |..   |.  .  ||||.  
pdw.qvpessevml...kilrkirar.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqq
0051082 (Phosphotyrosine protein) phosphatases II 689-866 1.2e-16 56.1 In-house 18-143 (151) alignment 
Range on Protein: 689-866
Range on HMM: 18-143/151.0
AESPmfntARNFWKMIDDRNVTAIVILCHENENNqeVCYQYWPSTSialvigeynitllnentnnryierkfevknnntgvkQSVTQFQITNWDSTGEVK
   |       |.... . ....|| |. | |..   |..|.|...                                      |....|..|. .|   
sggp....ladflellkelgiktivnlrseeerg..ycpeylpelg....................................ievlhipildwpdpglpl

NPQTILMIIEEMYRtqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVVSVQ
.....| ..|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||.    .
sfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl
0049772 (Phosphotyrosine protein) phosphatases II 678-873 2.1e-16 56.0 In-house 81-274 (314) alignment 
Range on Protein: 678-873
Range on HMM: 81-274/314.0
KGYkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVI---------------------LCHENENNqevcyQYWPSTSIALVIgeyni
.|.   ..||... |. .|  .|          |.|.  .|.||  ||.                     |.   .|.      ...   ..|       
dgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk.....

tllnentnnryierkfEVKNNNTGVKQSVTQFQITNWDStGEVKNPQTILMIIEEMYRTqrkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTeGVIDV
                |. ...  ... . ..  ....  |..  .. .. ..| . .    . .. ..|||.. .||.. |..||  . ...   . ..
................eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleea

FQVLKSQRIQKPGSvQTVVSVQLYLAYED
.. ....|  .|    .. . ..|. ...
ledvrlkRpinpnp.gfieqleqyefile
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 689-866 4.4e-16 53.2 In-house 96-278 (302) alignment 
Range on Protein: 689-866
Range on HMM: 96-278/302.0
AESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST-SIALVIGEYNITLLNENTN-NRYIER------KFEVKNNN--TGVKQSVTQFQI
   |  .|   .| .|.. ||. .| ||.  |.... | .|.       |  |.| .. .. .|. ... ..      . |.||..  . ||..|  .. 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWDSTGEVKNPQTILMIIEemYRTQRKrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQ
. |   |  |...| | |.   .    |   ....||||  |||.  . |    |. |... | |. ....  |  . |.||.   . 
sawpdhGapkeaytaldilk..fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 683-882 8e-16 52.5 In-house 95-291 (305) alignment 
Range on Protein: 683-882
Range on HMM: 95-291/305.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLlNENTNNRYIERKFEVKNNN------TGVKQSVTQF
.| || |. |. .|  .|| |. ...|  ||.||.  |  .  | |||| .    .     | . .. . .. .||  |..          . | || ..
ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivv.envsgskpmerdaeiqitllnltysgdqkmsvrhl

QITNWDSTGEvknPQTILMIIEEMYRTqRkRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVSvqlYLaYEDRI
| |.|   |    |   |  .| .    |   .  ||||||  .||.    |    ..|   .  .  . ...|. | |.  |.|. |    || .  |.
qwtewpdrgv...ppckltslellsai.r.gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvq...yl.fihrv

MSDYSMI
| .| . 
mlnyfle
0044763 (Phosphotyrosine protein) phosphatases II 698-866 1e-15 53.3 In-house 38-161 (178) alignment 
Range on Protein: 698-866
Range on HMM: 38-161/178.0
RNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIalvigeynitllnentnnryierkfevknnntgvkqsvTQFQITNWDSTGEVKNPQTILMII
 ...... . ..|.|| |..| |.... |..|||.                                          |.. ....  |.   .. .| ..
addlellkelgithivnlteelelgflkcdpywpeeag......................................iqylhipipDhgvpdllehflefv

EEMYRTQRkRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVVSVQ
| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..   ..
efieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 678-864 1.7e-15 51.8 In-house 76-259 (288) alignment 
Range on Protein: 678-864
Range on HMM: 76-259/288.0
KGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYnITLLNENT--NNRYIERKFeVKNNNTGVKQS-V
   | |. .| |..|.  |  ..|||. . .|  ||.||.  |  .|   .|.||    .  || .  |   ..    .. ..    ......| ..  |
ssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl.ctvvkkkradidklvkvsl.lriskegeekviv

TQFQITNWDSTGEVKNPQTILMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
 .  . .||  |  .| .. | ..| .     |  .  ||||.|  |||.. .      ..  . .  . . ..|.. | ..  ..||   
kilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 690-860 3.6e-15 50.9 In-house 66-243 (290) alignment 
Range on Protein: 690-860
Range on HMM: 66-243/290.0
ESPMFN-------TARNFWKMIDDRNVTAIVILCHENENNQE----VCYQYWPSTSI-ALVIGEYNITLLNENTNNRYIERKFEVKNNNtGVKQSVTQFQ
.||  .       |  .|| |. . .|. .| ||  .|....     | .| | .    | ..  ..   .  ...  ..|. .|| .. ...  ||  .
qsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsl

ITNWDSTGEVKNPQTILMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQ
. .|...   ....|.| .|. .     |  .| ..||| | . |||.. |      |   |.| . . .|||. | |.   ..
lkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralait
subfamily_CG42327_pd Subfamily CG42327 654-800 3.6e-14 47.1 In-house 41-190 (319) alignment 
Range on Protein: 654-800
Range on HMM: 41-190/319.0
KPKKPVIEEFPSDMTTEEGCQVLLKGYKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI---ALVIGEYNITLLNE
 . ..| .. ..|  .|      ..||.. .. .| |. .. ... .||... ...   || |.   |.  .|| .|.|.        . |.. .|| . 
PetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgr

NTNNRYIERKFEVKNNNTGVKQSVTQFQItNWDSTGEVKNPQTILMIIEEM
....||.   . .|. .    . .| .   .|  ..   ...... .. |.
evkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev
subfamily_egg_pd Subfamily egg 684-864 5.9e-14 46.4 In-house 83-258 (307) alignment 
Range on Protein: 684-864
Range on HMM: 83-258/307.0
KAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENnqEVCYQYWPS---TSIALVIGEYNITLLNENTNNRYIER--KFEVKNNNtGVKQSVTQFQi
  ||.|..|. ||  .||.|.   .|  ||.|    |.  | |  |||     |. .| | ..|. |. . .   . |  |. .   .   .. .  .| 
nefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwq.

TNWDSTGEVKNPQTILmiieemyRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVVS
 ... ...|  |  .|       |  |.   . .||.. . | ..| . |. ... .    | |  . ||..    | ... ||..|. 
gdvnnssdvysplrvl.......rklrnl.skpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvll
subfamily_hpo-7_pd Subfamily hpo-7 680-862 8.3e-14 46.1 In-house 31-213 (263) alignment 
Range on Protein: 680-862
Range on HMM: 31-213/263.0
YKEK---KAFIIaespMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYNITllNENTNNRYIERKFEVKN--NNTGVKQSV
 |.|   . ...    . .|  .|...|   . . .|.||  ||...| | .|.|      ... . |..    .. .  . .  |. .  ..    . |
ekdkkrknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc..ttkvqsdvllktlellstlgeKkkthtv

TQFQITNWDSTGEVKNPQTILMIIeemyRTQrkRGNTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTV
.... . |  . ...... || |.    .    |.  |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......| 
khysykgWiekndpelareilnil....kva..rnskslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtP
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 681-862 8.7e-14 46.2 In-house 29-207 (255) alignment 
Range on Protein: 681-862
Range on HMM: 29-207/255.0
KEK---KAFIIaespmfnTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYNITLLNenTNNRYIERKFEVKNNNTG--VKQSVT
|.|   . ...       |  .|...|   . . .|.||  .|...| | .|.|      |.. . |.|  .  . .  . |  |.  . .     . |.
kdkkrknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvk

QFQITNWDSTGEVKNPQTILMIIeemyRTQRKRgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTV
 .. . |      .... || |.    .  |.    |.|||||  .|||| |  |            . .| . .|  ..|.  | .......| 
hysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtP
fn3 Fibronectin type III domain 270-352 1.2e-13 44.1 Pfam-A 3-83 (85) alignment 
Range on Protein: 270-352
Range on HMM: 3-83/85.0
VDDIFFSSVESMSITVSWDEVPcnGRNGPITGYYLTYTNITSNT-SYTVNITGGNNrMYNLTGLIPYTNYTVSIIPYNYNMNGP
. .. .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|||| |.|.|....  .| . .||
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 685-833 1.2e-13 45.5 In-house 105-286 (350) alignment 
Range on Protein: 685-833
Range on HMM: 105-286/350.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIAL-----------VIGEYNITLL-----NENTNNRYIERKFEVKNNNT-
 .| . .|. .|  .|.|.|   .|. |. |  . |.| | ||.||.  |.             ..|  ...|      .| ..|  |. . ..|.||. 
kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsl

-GVKQS------VTQFQITNWDSTGEVKNPQTILMIIE--------EMYR--TQRKRGnTSIVVHCSDTVGRSAMFCAAATTI
  .. .      | |.|. ||   . . ||. || ..|         . .   . .|. ..|.||||  |||  ....    .
taitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtlDsll
fn3 Fibronectin type III domain 375-446 1.5e-13 43.8 Pfam-A 11-84 (85) alignment 
Range on Protein: 375-446
Range on HMM: 11-84/85.0
RTPTRINTVWNPPTIPNGIITVYEIRYRESTSTG-PYNITNTTNT-YYSIAGLIPNTSYTIGVRAYTSIGPGEW
.|.| ..  |.||. ..| || ||..|||..... . ..|.. .|  . . || |.|.|.. |.|..  | |..
vtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 681-864 2.1e-13 44.9 In-house 72-258 (285) alignment 
Range on Protein: 681-864
Range on HMM: 72-258/285.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALV-IGEYNITLLN--ENTNNRYIERKFEVKNNNTGVKQS--VTQ
|.. ..| .. |. .|  .||.|| . ... ...||   |   | |  |.|     .| .|.|.||| .  |..    |   . | | .    .   . .
kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnh

FQITNWDSTGevkNPQTILMIIeEMYRTQRK--RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
 |.  |        |.    .| |.|.  .|    .. |.||||  |||.| |     .  .   .  |.......  |  .  .||. . 
vqvpwwpdql...apedarpmi.elykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 681-860 4.6e-13 43.8 In-house 2-188 (199) alignment 
Range on Protein: 681-860
Range on HMM: 2-188/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYNITLLNENTNNRYIERKFEVKNNNTGV--KQSVTQFQ
| .. .| .. |. .|  .||.|. .     ||..  .. |..     |||.|   .   |  ..|     |.  |    . . || |     . ....|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

ITNWD--STGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQ
.| |   .| .|     ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . 
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiis
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 682-860 6.4e-13 43.3 In-house 2-187 (198) alignment 
Range on Protein: 682-860
Range on HMM: 2-187/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSI-ALVIGEYNITLLNENTNNRYIERKFEVKNNNTGV--KQSVTQFQI
 .. .| .. |. .|  .||.|. .     ||..  .. |..     |||.|   .   |  ..|     |.  |    . . || |     . ....|.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWD--STGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQ
| |   .| .|     ...   |. .   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . 
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiis
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 683-864 7.5e-13 42.7 In-house 93-278 (310) alignment 
Range on Protein: 683-864
Range on HMM: 93-278/310.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIER-KFEVKNNNTGVKQSV-----TQF
...|| .. |.  |  .||.|| .    .|..||.  |. .  |  ||||  ..   |   .| |.| ...  |         .|  | .        . 
rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrv

QITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNtsIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVS
.. .|    .   |.     . .   .| . |    |||||  ..|  . .|   .|.| .    .|. .|    . ..   .|| . 
slikwpnwpdrgvpdekchtvpqrllaqvrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelq
subfamily_ptpA1_pd Subfamily ptpA1 683-837 1.3e-12 42.2 In-house 88-257 (418) alignment 
Range on Protein: 683-837
Range on HMM: 88-257/418.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPST------SI----ALVIGEYNITLLNEN--TNNRYIERkfEVKNNNTGVK
 | || .. |. ||  .||.|. .  .  ||.| .|.|| .  | .|||        ||      |.| |.. |..     .   | |  ...    |  
pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitr..nirltfeget

QSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRK-----RGNTSIVVHCSDTVGRSAMFCAAATTINKCK
. .||.|   |         | .  ..  .   | .       |  |.||||  |||.  ||.|   ..|  
rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkld
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 662-782 1.7e-12 41.4 In-house 214-329 (440) alignment 
Range on Protein: 662-782
Range on HMM: 214-329/440.0
EFPSDMTTEEGCQVLLKGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILcheNENNQEVCYQYWPSTSIALVIGEYNITLLNENTNNRYIERKFE
..|.  | .   |  ..||  |.||| .. |.  |  .||... | ....|..|   |. |.  |  |||  . .. .| . .     .  ||   | .|
qwpnphtdksplqqefegyskknafiatqmpldstvldfwrlvhdyristiiml...nqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtle

VKNNNTgVkQSVTQFQITNWD
.| ..  | . . ||..  | 
lkykee.v.heirqfevqtwp
0048076 (Phosphotyrosine protein) phosphatases II 748-864 5.1e-12 41.2 In-house 22-131 (145) alignment 
Range on Protein: 748-864
Range on HMM: 22-131/145.0
NENTNNRYIERKFEVKNNNTGVKQSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKrgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQV
 |.  .  | . . . .. ..... ..|.. ..|.  |.   ....| ..| . . ...  .  ..||||  |||.....||   .     .| ......
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleea

LKSQRIQKPGSVQTVVS
|.  | | ||.|...  
lelvrsqrpgavpnpgq
0048179 (Phosphotyrosine protein) phosphatases II 703-864 6.9e-12 40.8 In-house 24-133 (144) alignment 
Range on Protein: 703-864
Range on HMM: 24-133/144.0
MIDDRNVTAIVILCHENENNQEVCYqywpstsialvigeynitllnentnnryierkfevknnntgvkqsVTQFQITNWDSTGEVKNPQTILMIIEEMYR
.. . ..|... |..| |.. . ..                                             ..|.. ..|.  |    .. .| ..| . .
llkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefiee

TQRkrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVVS
 ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|..   
ale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 771-863 4.7e-11 36.7 In-house 89-181 (440) alignment 
Range on Protein: 771-863
Range on HMM: 89-181/440.0
QSVTQFQITNWDSTGEVKNPQTILMIIEEMYRTQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
... |..   |   |  |    .| .|...  .| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  |||  
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 683-862 4.9e-11 36.9 In-house 87-273 (305) alignment 
Range on Protein: 683-862
Range on HMM: 87-273/305.0
KKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS---IALVIGEYNITLLNENTNNRYIERKFEVKNNNT--------GVKQ
 | || ...|. .|  .|| |  . .| || .||   |   . |..|..|     . .  ..  |..  | ...  .... . | ..|        . ..
pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekar

SVTQFQITNWDSTGevkNPQTILMIIEEMYRTQRKRGntSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQTV
 ||..   .|   |    | . | |.| . ...  .|   ||||||  .||.         ...  .  .|.   ..|.  | |.  |.|| 
kvthyhwidwpdrg...vpaadlailellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 685-793 5.4e-11 36.6 In-house 138-242 (244) alignment 
Range on Protein: 685-793
Range on HMM: 138-242/244.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQevcyqYWPStSIALVIGEYNIT--LLNENTNNRYIERKFEVKNNNTGVKQSVTQFQITNWD
 .|... |. .|. .||||. .| |  .|.|   .|...     |||  |  |   | .||  | . .        ..|.. .    .|..| |||.|| 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpd.seplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwp

STGEVKNPQTI
| |   |   |
sdgttpndhfi
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 684-789 7e-11 36.5 In-house 28-129 (130) alignment 
Range on Protein: 684-789
Range on HMM: 28-129/130.0
KAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQevcyqYWPStSIALVIGEYNITL-LNENTNNRYIER-KFEVKNNNTGVKQSVTQFQITNW
. .. .. |. .|. .||||. .| |  .|.|   .|...     |||  |  |   | .|.. | .  . ..|.  ..|....    .|..| |||.||
aeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpd.sePlewyeediivtltdrdefknikasnleiesdlneshqaltmfqisnw

DSTGEVKN
 | |   |
psdgttpn
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 684-863 1e-09 32.6 In-house 82-263 (312) alignment 
Range on Protein: 684-863
Range on HMM: 82-263/312.0
KAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTsIAL-------VIGEYNITL-LNENTNNRYIERKFEVKNNNTGVKQSVTQ
. |.....|. ||. .||..      |.|..||   |.  | | .|     ...       |  ||   . .  .....   | . |  . || .  . .
erfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi.vgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnh

FQITNWDSTGEVKNPQTILMIIEEMyrtqrKRGNTSIVVHCSDTVGRSAMFCAAA---TTINKCKTEGVIDVFQVLKSQRIQkpgSVQTVV
.| . |   |     .| | ..  .     |. .  .. |||  |||.  ..      ... . . . | |.| .|. .| .   ||... 
yqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrar...svrvfp
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 685-863 1.6e-09 31.6 In-house 91-272 (302) alignment 
Range on Protein: 685-863
Range on HMM: 91-272/302.0
AFIIAESPMFNTA---RNFWKMIDDRNVTAIVILCHENENNQeVCYQYWPSTSIALVigEYNITLLNENTNNRYIERK--FEVKNNNTGVKQSV--TQFQ
  |.|  |  ...    .||.|. ..... .|||  |.| ..    ...| .| . .  ||.   .|    ..  | |  . .     |. .||  .   
siilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyk..eygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyv

ITNWDSTGEVKNPQTILMIIEEMYRtQRKRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.||| ..   ..  ..   .....  .   .. ..|.     .|| ..| ..|....| ...    . ...|| | |.| .|... 
ltnWkqkkvpvkyaeliktaakvfa.kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 685-734 3.3e-09 31.0 In-house 77-126 (297) alignment 
Range on Protein: 685-734
Range on HMM: 77-126/297.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS
 .|.|. |. .|  .||... ...| .||.... .|. .. |. ||||. 
kyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 682-834 1.8e-08 28.1 In-house 105-290 (349) alignment 
Range on Protein: 682-834
Range on HMM: 105-290/349.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-----IALVIGEYNITLLNENTNNRYIERKFEVKNNNT---------
 .| .|    |.  |  .|.|.|   .|  .. | ...|.. | |..||   |     . |     .|. .. |. . . ... . .|.|          
vekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpdd

----G----VKQ--SVTQFQITNWDSTGEVKNPQTILMIIE-------EMYRTQ-R-KRGNTSIVVHCSDTVGRSAMFCAAATTIN
         |..   . |.|. ||  .. . ||..||  .|       ...  .   .   ....||||   ||. ...     ..
ddddaillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
Herpes_gE Alphaherpesvirus glycoprotein E 552-631 1.5e-06 16.8 Pfam-A 331-404 (439) alignment 
Range on Protein: 552-631
Range on HMM: 331-404/439.0
PGTPVMPTTTTSDEG-SMTIVFIAVGAIVCILVLIVIIIIIVVVVVLKKRRGSNDFdinpkntSTSKPEATVYYSTCKSNN
| .. .|..... .. . .   . ..|.....||.......|.|.| |.|| ..         .. .|...|| |  ... 
ppatpapsaepakpeartapyllllaavlgaavlllvvlllvlvcvtkrrrrkaye.......krlspfspvYtsLPtnel
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 798-867 2.4e-06 21.6 In-house 218-286 (297) alignment 
Range on Protein: 798-867
Range on HMM: 218-286/297.0
EEMYRTQRKRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVSVQL
 | .|..  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.   .|
leslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfel
subfamily_eak_pd Subfamily eak 685-786 4.8e-06 20.2 In-house 94-194 (332) alignment 
Range on Protein: 685-786
Range on HMM: 94-194/332.0
AFIIAESPMFNTARNFWKMIDDRNVTAIVILCHENENNQEVCYQYWPSTS-IALVIGEYNITLLNENTNNRYIERKFEVKNNNTGvkQSVTQFQITNWDS
 .|..  .  .    ||.|. ...  ||| | .. |.. |   .|.|  .   |  | ....  .   .| .  |..|..  |      |  ...  |  
kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnet..hrvlhykvfGwte

TGE
|  
ttl