Gene PTPRD-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP084_AA protein Get Run
AqueP084_AA_7-150 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 10-148 1.7e-46 154.0 In-house 36-173 (564) alignment 
Range on Protein: 10-148
Range on HMM: 36-173/564.0
DDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNY--DSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQ
. | .. |. . | || |... .. .  |||||. .   .|||| ||..||||.| |.||||||...|  |||||||| .| .|.|||..||.|...  .
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPVNpNeEDMYGSFNvVALPEDRTLPDYVVRKFKLSHSKN
||| . . .  ||..  | | |  .| ||..|.|||...|.
YWPek.g.tetygelt.Vtleeeeeladyeirtfklkkkks
0050432 (Phosphotyrosine protein) phosphatases II 10-147 1.5e-44 148.0 In-house 56-192 (308) alignment 
Range on Protein: 10-147
Range on HMM: 56-192/308.0
DDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLstkNYDSDYICASYVDGY--RQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQ
.....|.|.| .|  | | |  ||    ||.|   . .||||.|||||||  ... .|||||||..|| .|||||||| .. .|.|||...||| |.  |
plleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaq

YWPVNPN-EEDMYGSFNVVALPEDRtLPDYVVRKFKLSHSK
||| ... .  .|| | |  | |.  |.||.||...|....
Ywplelgggsleygkftvtllseev.lddytvrtleltnlg
0036941 (Phosphotyrosine protein) phosphatases II 8-146 5.4e-44 146.1 In-house 25-162 (297) alignment 
Range on Protein: 8-146
Range on HMM: 25-162/297.0
TDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLstKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQ
   ....|.|.| .|| | | |  || .. ||.|  .. .||||.|||||||..  .|||||||..|| .|||||||| .. .|.|||. .|.| |.  |
llllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaq

YWPVNPNEEDMYGSFNVVALPEDRT-LPDYVVRKFKLSHS
||| . .|.  || | |  | .. . |.||..|...... 
ywpleegesltygdftvtllsvevvllddytlrtlevtdt
0051299 (Phosphotyrosine protein) phosphatases II 11-146 7.1e-44 145.8 In-house 38-172 (288) alignment 
Range on Protein: 11-146
Range on HMM: 38-172/288.0
DFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNY--DSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQY
|...|.|.|  || | | .  || .. ||.||. .   .||||.|||.|||..  .|||||||..|| .|||||||| .. .|.|||...|.| |.. ||
dltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqY

WPVnpNEEDMYGSFNVVALPEDRtLPDYVVRKFKLSHS
||   ..  .|| . |  | |.  |.||.||...... 
wpl..ggsltygditvtllseev.lddytvrtlevtnl
0046845 (Phosphotyrosine protein) phosphatases II 10-147 4e-43 143.2 In-house 16-159 (284) alignment 
Range on Protein: 10-147
Range on HMM: 16-159/284.0
DDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD---SDYICASYVDGY-----RQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENG
  ...|.|.|  || | | |  || .. ||.|.. . |   |||| |||||||     ... .|||||||..|| .|||||||| .. .|.|||...|||
lllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelveng

EEQSVQYWPVNpNEEDMYGSFNVVALPEDRtLPDYVVRKFKLSHSK
 |.  |||| . .|  .|| | |  | |.   .||.||...|.. .
rekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlg
0047943 (Phosphotyrosine protein) phosphatases II 10-147 2e-42 140.9 In-house 26-161 (273) alignment 
Range on Protein: 10-147
Range on HMM: 26-161/273.0
DDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLstKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYW
.....|.|.| .|. | | |  || .. ||.|  .. .||||.|||||||..  .|||||||..|| .|||||||| .. .|.|||...|.| |.  |||
plltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYw

PVNPNE-EDMYGSFNVVALPEDRtLPDYVVRKFKLSHSK
| . .| . .|| | |  | |.   .||.||...|....
pleggelsltygkftvtllseet.kddytvrtleltnlg
0040438 (Phosphotyrosine protein) phosphatases II 11-148 8.9e-42 138.9 In-house 33-168 (317) alignment 
Range on Protein: 11-148
Range on HMM: 33-168/317.0
DfDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNY--DSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQY
| ..|.|.| .|  | | .  ||  . ||.||  ..  |||||.||||||.... .|||||||..|| .|||||||| .. .|.|||..||.| |.. ||
d.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqY

WPVnpNEEDMYGSFNVVALPEDRtLPDYVVRKFKLSHSKN
||   .|.  || | |  | |.  |.....|.........
wpl..getltygdftvtllseee.lagitlrtlevedlgd
DSPc_SM00195 9-148 7.6e-41 135.5 In-house 16-154 (263) alignment 
Range on Protein: 9-148
Range on HMM: 16-154/263.0
DddfDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSV
.   ... |. . | .| | |..|| .. || |....   .||||.|.|..|.......||||||...|  ||||||||.|. ||.|||. ||||.|.  
k...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

QYWPVNPNEEDMYGSFNVVALPEDRTLPDYVVRKFKLSHSKN
.||| . ...  .|...|    .. .  ....|...|.. ..
rywpeesggketfgkisvklvevekkkdeiilrtleltkegk
PTPc_SM00194 9-148 7.6e-41 135.5 In-house 16-154 (263) alignment 
Range on Protein: 9-148
Range on HMM: 16-154/263.0
DddfDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSV
.   ... |. . | .| | |..|| .. || |....   .||||.|.|..|.......||||||...|  ||||||||.|. ||.|||. ||||.|.  
k...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

QYWPVNPNEEDMYGSFNVVALPEDRTLPDYVVRKFKLSHSKN
.||| . ...  .|...|    .. .  ....|...|.. ..
rywpeesggketfgkisvklvevekkkdeiilrtleltkegk
0045450 (Phosphotyrosine protein) phosphatases II 8-146 1e-40 135.8 In-house 41-188 (307) alignment 
Range on Protein: 8-146
Range on HMM: 41-188/307.0
TDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNY---DSDYICASYV--------DGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTN
... ...|||.|  |  | | |. || .. ||.||. .    ||||| ||||        |||..  .|||||||...|  |||||.|| .. .|.|||.
vfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmlte

TEENGEEQSVQYWPVNpNEEDMYGSFNVVALPEDRtLPDYVVRKFKLSHS
..|.| |. .|||| . .|| .|| | |  | |.  |..|.||.......
lvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdl
0043336 (Phosphotyrosine protein) phosphatases II 12-147 2.6e-40 134.1 In-house 35-168 (278) alignment 
Range on Protein: 12-147
Range on HMM: 35-168/278.0
FDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYW
...|||.| .|  | | |  || .  ||.||  ..|  ||||.|||||||..  .|||||||...| .|||||||| .. .|.|||. .|.| ....|||
dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYw

PvnpNEEDMYGSFNVVALPEDRtLPDYVVRKFKLSHSK
|   ..   || | |  | |.  |.||.||...... .
p...ggsltygdftvtllkeeh.lddytvrtlevtnlg
0039614 (Phosphotyrosine protein) phosphatases II 13-150 3.6e-40 133.7 In-house 47-182 (297) alignment 
Range on Protein: 13-150
Range on HMM: 47-182/297.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN---YDSDYICASYVDGYRQ-RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEeQSVQY
|.|||.|  |  | | |..|| .. ||.|....    |||||.|||||||..   .|||||||...| .|||||||| .. .|.|||...|.|  . .||
dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqy

WPVNPNeedMYGSFNVVALPEDRtLPDYVVRKFKLSHsKNVS
|| . .   .|| | |  | ..  |..|.||...... .. |
wpeegg...tygdftvtllkveh.ldgytvrtlevtn.nges
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 13-147 3.7e-39 129.7 In-house 37-172 (305) alignment 
Range on Protein: 13-147
Range on HMM: 37-172/305.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWP
 . . . . | ||.|.||  . .| |. |..|.   ||||| |||||||... ..|..|||.|||  ||||...|.|   |.|||.. |.|...  ||||
sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWp

VNPNEEDMYGSFNVvALPEDRTLPDYVVRKFKLSHSK
 . .|.  .|.|.|  | . .| .||. ||.|.|  .
esktekkefgefsv.elksektasdyieRklkisied
Y_phosphatase Protein-tyrosine phosphatase 22-148 1.2e-38 128.2 Pfam-A 1-128 (235) alignment 
Range on Protein: 22-148
Range on HMM: 1-128/235.0
NLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGS
|. | | |. || .. || |. .. .|||| |.||.||.. ..|||||||.|.| .|||||||. |. .|.|||. ||.|.|.  |||| . .|. .||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

FNVVAL-PEDRTLPDYVVRKFKLSHSKN
..|     | .   .|..||..|...|.
ikvelkekekedekeytlrklelkkkke
Y_phosphatase Protein-tyrosine phosphatase 22-148 1.2e-38 128.2 In-house 1-128 (235) alignment 
Range on Protein: 22-148
Range on HMM: 1-128/235.0
NLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGS
|. | | |. || .. || |. .. .|||| |.||.||.. ..|||||||.|.| .|||||||. |. .|.|||. ||.|.|.  |||| . .|. .||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

FNVVAL-PEDRTLPDYVVRKFKLSHSKN
..|     | .   .|..||..|...|.
ikvelkekekedekeytlrklelkkkke
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 16-148 2.9e-38 126.7 In-house 40-171 (318) alignment 
Range on Protein: 16-148
Range on HMM: 40-171/318.0
IAQLSDNLAKSRVKEHLPPNDYRVVLSTK--NYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNp
 .  . | || |    |. .. || |...  . .|||| |.|.||||.. |.||.|.|. .|  |||||||| .|..|.|||..||.| ..  .||| . 
kslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk.

nEEDMYGSFNvVALPEDRTLPDYVVRKFKLSHSKN
 .   ||.   | | |. .| |||.|.||......
.gsrsygklv.velkeevelsdyvlrefkvtrtee
subfamily_PTPRA_pd Subfamily PTPRA 13-145 5.8e-38 125.6 In-house 49-180 (330) alignment 
Range on Protein: 13-145
Range on HMM: 49-180/330.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWP
 . .|.  .|  |.|| . || .  ||.||.|.   .|||| ||..|||...  |||.||| ..|  |||||.|| ||. |.|||. .|  ||.  ||||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

VNPNeeDMYGSFNVvALPEDRTLPDYVVRKFKLSH
 .      ||  .| .. ..  | || |||| . .
deGl..vtyGnirv.evedetvlvdytvrkflvqq
subfamily_Ptp69D_pd Subfamily Ptp69D 11-155 7.3e-38 125.4 In-house 37-180 (307) alignment 
Range on Protein: 11-155
Range on HMM: 37-180/307.0
DFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQY
| ......  .|. | | ..  . ...||.|.. |   ||||| ||.. ||...  ||| |.|. .|.||||||..| .. .|.||.| .|  ...  .|
dkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakY

WPVNpnEEDMYGSFNVVALpEDRTLPDYVVRKFKLSHSKNVSYVCNE
||..  .|  ||. .|    . .. .||. |....|. |. |   ..
Wpie..devqygdilvklv.seekhsdyiiReldvskkkeesgeved
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-148 8.5e-38 125.3 In-house 36-181 (298) alignment 
Range on Protein: 2-148
Range on HMM: 36-181/298.0
LESSSPTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLST--KNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEE
|.| | . ...  ..|. ..|  | |  . .. .  ||||..  .. .|||| ||....|..|.||||||.|...|  ||||||.| ..  |.||||.||
lnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnlee

NGEEQSVQYWPVNpnEEDMYGSFNVvALPEDRTLPDYVVRKFKLSHSKN
 .. .  .||| .  ... ||...|  | .. .  |..|||.|.|..|.
ldktkyhkywPde..gketygeitv.sllskeefadlivrklkvskkke
0040439 (Phosphotyrosine protein) phosphatases II 13-148 1e-37 125.5 In-house 2-136 (249) alignment 
Range on Protein: 13-148
Range on HMM: 2-136/249.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWP
..|.|.|  |. | | . .||..  ||.||  .  ..||||.|||.|||..  .|||||||...| .|||||.|| .. .|.|||...|.| |.  ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

VnpNEEDMYGSFNVVALPEDRtLPDYVVRKFKLSHSKN
   ...  || | |  | ..  ..||.||...|.....
l..ggsleygdftvtllsvev.kddytvrtleltnlyd
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 9-147 1.1e-37 124.6 In-house 36-167 (287) alignment 
Range on Protein: 9-147
Range on HMM: 36-167/287.0
DDDFDCSIAqlSDNLAKSRVKEHLPPNDYRVVLStkNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQY
.|.   .||  |.|  | |... |.|..|||.|   . . ||| |...|||... |||....|| ||| .||..... .  .|.||.. .|| ||.  ||
edevthnia..sqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqy

WPVNPNeeDMYGSFNVVALPEDrTLPDYVVRKFKLSHSK
|| . .   ..| .|.  | |. .  .|..||... ...
Wpeeks..vvlGeyniellnee.vnagyierklevknkn
subfamily_PTPRB_pd Subfamily PTPRB 11-151 2.2e-37 123.7 In-house 40-180 (293) alignment 
Range on Protein: 11-151
Range on HMM: 40-180/293.0
DFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQY
|  ...|.|. | || | .. || .  || |   ... .|||| |.|..||...  |||||||. .|  |||||||| || ||.|||.. |.| ..  .|
dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeY

WPVNPNEEdMYGSFNVVaLPEDRTLPDYVVRKFKLSHSKNVSY
|| . ..  .||. .|  | ....| |.|.|..|....|.   
WPadeepv.lyGdikvt.lvaeeeledwvirelkiekekeerk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 9-147 2.3e-37 123.5 In-house 33-172 (290) alignment 
Range on Protein: 9-147
Range on HMM: 33-172/290.0
DDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYDSD----YICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQ
. ..   ..  |.|  . | .. ....|.|..|  .. . |    || |.|..||... ..||||||..||. |||...|. |. ||.||||  |.|...
esehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvk

SVQYWPVNPNEEdmYGSFNVVaLPEDRTLPDYVVRKFKLSHSK
  |||| .....  || |..  | ...|| .|. ||... ...
CqqYWpdsdtka..ygefsik.llneetlneyierklevknkn
subfamily_PTPN9_pd Subfamily PTPN9 16-148 3.4e-37 123.1 In-house 36-169 (297) alignment 
Range on Protein: 16-148
Range on HMM: 36-169/297.0
IAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNP
 ..|  || | | .. |  .. ||||.... |  |||| |..||||.|. ||||||||.|.|  |||||||| . ..|.| | ..|.|  .  |||| . 
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWplee

NEEDMYGSFNVVALpEDRTLPDYVVRKFKLSHSKN
.. . .|...|  . |...  ||.||.......|.
essaefgdlsvsnv.eveeeedykvrvleiknvkt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 15-150 7.5e-37 121.9 In-house 2-135 (250) alignment 
Range on Protein: 15-150
Range on HMM: 2-135/250.0
SIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEqSVQYWPVN
|.|.  .|. | |  . .. .  |||| ...   .|||| ||...||..|.||||||||...|  ||||||.| ||  |.|||| .|....   |||||.
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

PNEedMYGSFNVVALPEDrTLPDYVVRKFKLSHSKNVS
  |   ||.  |  | .. .  ||..||.|||. |. .
kae..kyGdvtvsllske.efadytkrklklskakkad
subfamily_PTPRG_pd Subfamily PTPRG 8-147 1.3e-36 120.9 In-house 33-172 (563) alignment 
Range on Protein: 8-147
Range on HMM: 33-172/563.0
TDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN-YD--SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQ
...|.|.. .|  .|  | |  . .. .  || ||     .   ||| |.|.|||..  ||||||||.|.|. |||||.|| .. ||.|.|| .|.| ..
iskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrk

SVQYWPVnpNEEDMYGSFNVvALPEDRTLPDYVVRKFKLSHSK
  .|||   .|   ||...|  | |  .|  | ||.... . |
cdvYWPk..desetygalqv.tlieeevlalytvrtlviknlk
0042113 (Phosphotyrosine protein) phosphatases II 14-148 7.3e-36 119.2 In-house 1-134 (245) alignment 
Range on Protein: 14-148
Range on HMM: 1-134/245.0
CSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPV
.|.|.|  |  | | .. || .. ||.||  ..|  |||| ||||||||.   |||||||...| .|||||.|| .. .|.|||..||.| ... |||| 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

npNEEDMYGSFNVVALPEDRtLPDYVVRKFKLSHSKN
  .|.  || | |  | |.  |.||.||...... ..
..gesltygdftvtllseeh.lddytvrtlevtnlgd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 10-147 8.2e-36 118.7 In-house 36-172 (319) alignment 
Range on Protein: 10-147
Range on HMM: 36-172/319.0
DDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTK--NYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQ
.... . |.  .|  | | .. |. .  |||||.     .|||| ||..|||..|..|||||.|..||  |||||||| .|.|..|||.  |... .  .
vndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkk

YWPVNpnEEDMYGSFnVVALPEDRTLPDYVVRKFKLSHSK
||| .  .   || . .| | |.. | ||..||.|| . .
ywpee..nfeeyGrl.ivtleeeeeledyiirklklnkks
0045098 (Phosphotyrosine protein) phosphatases II 13-146 1.1e-35 118.8 In-house 24-144 (278) alignment 
Range on Protein: 13-146
Range on HMM: 24-144/278.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVlstknydsDYICASYVDGYrqRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPvN
... |.. .||.| | |. || .  ||.        ||| |||.|||  . .|||||||...|. |||||.||... .|.|||. .|.| |  .|||| .
eitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e

pNEEDMYGSFNVVALPEDRTlPDYVVRKFKLSHS
 ..   || | |  | |... .||..|.... . 
.ggsltygdftvtllseevl.ddytlrtllvtnl
subfamily_PTPN6_pd Subfamily PTPN6 13-148 3.1e-35 116.7 In-house 45-181 (306) alignment 
Range on Protein: 13-148
Range on HMM: 45-181/306.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVL-STKNYDSDYICASYVDGYRQ--RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYW
. . ..  .|  | | |  || .. ||.| . . ..|||| |.|...  .  . ..||||| ...|  |||||||. .| .|.|.|.  | |.|. ..||
srkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYW

PVNPNEEDmYGSFNVVALPEdRTLPDYVVRKFKLSHSKN
| . ..|. ||. .|  . | ..| ||..|....|. |.
Pdeeekee.yGkisvtnvse.ksladYilRelsvskkkk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 12-148 5.5e-35 115.8 In-house 37-173 (288) alignment 
Range on Protein: 12-148
Range on HMM: 37-173/288.0
FDCSIAQLSDNLAKSRVKEHLPPNDYRVVLST--KNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYW
 . ....|. |  | | .. || .  || |    .. ..||| |||.||.... ..||||||. .| .|||..|.| |.  |.|||.  |.|...  .||
ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYW

PVNpNEEDMYGSFNVVaLPEDRTLPDYVVRKFKLSHSKN
| . ...  |||..|. | |...| |.|.||. | ..|.
Pda.dkpknyGsvtvt.lveskeledfvlrklllekkkt
subfamily_PTPRK_pd Subfamily PTPRK 17-146 1.4e-34 114.4 In-house 38-165 (314) alignment 
Range on Protein: 17-146
Range on HMM: 38-165/314.0
AQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPvnpN
|.  .| .|.|... |...  ||.| | . |  |||| |...|.|.. .|||.||||...|  ||||.|.. ..  |.|||.  |.|  . ..|||   .
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP...e

EEDMYGSFNVVALpEDRTLPDYVVRKFKLSHS
. ..|| ..|  . |  .| ..||| |.....
dtevygdikvelv.etellaelvvrifrvekl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 10-144 3.2e-34 113.0 In-house 28-165 (301) alignment 
Range on Protein: 10-144
Range on HMM: 28-165/301.0
DDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNY----DSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQS
.|  |..   ..| | .| |.  . .| |..|..|.       .|| |||.|||... .|||.|||||.|  ||||..|. | . |.|.||..|. ....
edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskc

VQYWPVNPNEEDMYGSFNVvALPEDRTLPDYVVRKFKLS
 ||||   .|.. .| |.|  | .. ..||.|.|.... 
eqywpnseaeseefgpftv.tlvneqvyPdfvirqlnvk
subfamily_PTPN3_pd Subfamily PTPN3 10-147 8.7e-33 108.4 In-house 29-166 (280) alignment 
Range on Protein: 10-147
Range on HMM: 29-166/280.0
DDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYdsDYICASYVD----GYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQS
 . ..|.|....||.| | .. || .. || |.  .   ||| |.||.    .  .   .||||||...|| |||.|||| || .|.|||.. |.|  . 
pglaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

VQYWPVnPNEEDMYGSFNVVALPEdRTLPDYVVRKFKLSHSK
 ||||  ...|  ||.|.|.   | ..   ||.|.. |....
hqyWPe.tedeleygefsvkceke.detksyvlrelvlkdke
0037934 (Phosphotyrosine protein) phosphatases II 13-147 1.5e-32 108.5 In-house 1-127 (243) alignment 
Range on Protein: 13-147
Range on HMM: 1-127/243.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLstknYDSDYICASYVDGYRQrsaFIATQGPMKNTAGD----FWRMVWEMKSMIIIMLTNTEENGEEQSVQY
..|||.|  || | |..  || .. ||.|     .||||.|........   .||||||...|  |    ||||.|| .. .|.|||...|.| |. .||
sfsiallpenlsknrysdilpydhsrvkl....egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPvnpNEEdMYGSFNVVALPEDRtLPDYVVRKFKLSHSK
||   .|. .|| | |  | |   |.||.||...|.. .
wp...gev.tygdftvtllseeh.lddytvrtlllenld
subfamily_PTPN12_pd Subfamily PTPN12 9-149 5.9e-32 105.7 In-house 27-169 (290) alignment 
Range on Protein: 9-149
Range on HMM: 27-169/290.0
DDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSV
.. .  . .. . | .| | |. || .  ||.||...   .|||| |... |  .. ..||.|||. .|  |||||.||..  |..|. .  |.|  .  
ekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe

QYWPVNPNEEDMYGSFNVVALPEDRTLPDYVVRKFKLSHSKNV
.||| . .|| ..|.|.|    |...  |...| .|. ..|. 
rYWpeegeeelefgefevtleeekavdddflirtLkveaqkes
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 21-147 1.1e-31 104.7 In-house 37-163 (287) alignment 
Range on Protein: 21-147
Range on HMM: 37-163/287.0
DNLAKSRVKEHLPPNDYRVVLS-TKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNpNEEDMY
 .  | |  . || .| ||.|| . .. |||| | || .|..  ||||.|||.  | .||||.|.| .|  .|..|   |..  .  .||| . .   . 
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrv

GSFNVVALPEDRTLPDYVVRKFKLSHSK
| . ||.|  |   |.| || ..| . .
GGysvvlldydikePeygvralrlidle
subfamily_PTPN23_pd Subfamily PTPN23 12-147 2.3e-31 103.7 In-house 33-166 (288) alignment 
Range on Protein: 12-147
Range on HMM: 33-166/288.0
FDCSIAQLSDNLAKSRVKEHLPPNDYRVVLStkNYDSDYICASYVDGYRQRS-AFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWP
 . |||    .  | | .. || .  ||.|   .   ||| ||.| .    .  |||||.|...|..|||.||.| || .|.||.. || |...  .|||
rkrsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

VNPNEEDMYGSFNvVALPEDRTLPDYVVRKFKLSHSK
 . .|   .| .. |.| . |... .| |..||.. .
edkgetvkfgdls.vtlksvretethvervlkletld
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 18-148 1.2e-30 101.6 In-house 24-159 (274) alignment 
Range on Protein: 18-148
Range on HMM: 24-159/274.0
QLSDNLAKSRVKEHLPPNDYRVVLSTKN---YDSDYICASYVDGYRQR-SAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNP
... .  | | |. || .  ||.|....    ||.|| | |. ||...  |..|||||. ||  |||||... .. .|.|||. .|. |.. ..|.| . 
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

NE--EDMYGSFNVVaLPEDRTLPDYVVRKFKLSHSKN
.   .. || ...    .  .  || |||. |.....
dyeiserygdveik.vekiverndysvrklvlkyler
subfamily_PTPN14_pd Subfamily PTPN14 8-145 1.6e-30 101.1 In-house 35-176 (300) alignment 
Range on Protein: 8-145
Range on HMM: 35-176/300.0
TDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL-STKNYDSDYICASYVDGY--RQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQ
   | ..| |.| .|  |.|.|. || .| || | .||. ...|| || .      ..  .|..|||...|  |||.|||| .  .|.|||..||.| |.
kredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

SVQYWPVN--PNEEDMYGSFNVVALPEDRTlPDYVVRKFKLSH
|..|.| .   ...  .| |.|..   . . . .. ...|| |
sfkyfPkleskkktvefgkfkvttkfseds.dsvittglklkh
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 14-147 1.9e-30 101.2 In-house 53-179 (319) alignment 
Range on Protein: 14-147
Range on HMM: 53-179/319.0
CSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTnteengEEQSVQYWPV
 . | | .|  | |. . |. .  .| |   .    |||| ||.|.||...  .||.|||..||  |||||.||...  |..||      ...  |||| 
qtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywpl

NPNEEDMYGSFNVVALPEDRTlpdYVVRKFKLSHSK
. ....  .  .| .. |      ||||...||.  
kivikeerfkvkvdsveetae...yvvrdielsedg
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 13-147 2.4e-30 101.0 In-house 16-143 (284) alignment 
Range on Protein: 13-147
Range on HMM: 16-143/284.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTK--NYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTnteengEEQSVQYWP
| . | | .|  | |. . |. .  .| |     .  |||| ||.. ||...  .||||||..||  |||||.||...  |..||      ...  ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

VNPNEEDMYGSFNVVALPEDRTlpdYVVRKFKLSHSK
 . ....  .  .| .. |      ||||...||.  
lkivikeerfkvkvdsveesee...yvvrdielsedg
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 12-152 5.2e-30 99.4 In-house 39-177 (315) alignment 
Range on Protein: 12-152
Range on HMM: 39-177/315.0
FDCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYW
.   .|. . |  | |  . .. .  || |    .. .|||. |...||| ..  .||.|||  .. .||||.|.| .   |.||||. |. .... .||
hpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekyw

PVNpneEDMYGSFNVVALPEDrTLPDYVVRKFKLSHSKNVSYV
| .   . .|| . |    |.    .| || .     .|.  |
pdk...kviyGkitvtrksee.vnteytvrtlsvvfgdnirev
subfamily_CG7180_pd Subfamily CG7180 12-146 9.4e-30 98.2 In-house 32-164 (296) alignment 
Range on Protein: 12-146
Range on HMM: 32-164/296.0
FDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTK--NYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEeQSVQYW
 ||  .  ..|. | |  . .|..  ||||..   . .|||| |.|||.. .  ..| |..|.|.| ..|||.|.. ..  ...||.| .  . .  .||
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PVNPneEDMYGSFNvVALPEDRTLPDYVVRKFKLSHS
| .   .  || .  | . | ..... . |.||| . 
pnks..keqygeif.veiveekqyanlkirtfkltkk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 7-147 3.9e-29 96.8 In-house 33-173 (325) alignment 
Range on Protein: 7-147
Range on HMM: 33-173/325.0
PTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIiIMLTNTEENGEEQ
|.||     .| . .| || | |. .. .  |||| ||. |  |||| |||.  ....  |.|.| |. .| .|.||.| . .. . ....|  ..|...
psddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsv.vvvlneldlgkdr

SVQYWPVNPNEEDMYGSFNVVaLPEDRTLPDYVVRKFKLSHSK
  .||| .  .   .|...|  |    .. ||| |....   |
cavywpkemgksktfGglevk.lrtieeisdyvhrvldvkqvk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 17-147 4.2e-29 96.5 In-house 36-166 (281) alignment 
Range on Protein: 17-147
Range on HMM: 36-166/281.0
AQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPvNPN
..  .|  | | .     .  ||..  . .| ..||| |..|.||..  ..||||||. ..  .||.|||| |  .|.|.|.  |.|  .  .||| ..|
skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddn

EEDMYGSFNVVALPEdRTLPDYVVRKFKLSHSK
.|  || . |  . | .. . |. |||||....
selkygdvtvkstae.eekatyierkfkleres
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 8-151 1.5e-28 94.6 In-house 30-174 (315) alignment 
Range on Protein: 8-151
Range on HMM: 30-174/315.0
TDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQS
  | .   .|. ..|  | | |. || .  ||.|    .. ||||| |||. .. .  |.||.||| | .  ||||||.. |   |.|.|. .|.   . 
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc

VQYWPVNPNEEDMYGSFNVVALpEDRTLPDYVVRKFKLSHSKNVSY
 |||| .  .   .||..|  | .  .  | |.||. . .|..   
rqywPdrkadsvefGsikvell.sleadtdgvarklvtrkseesrt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 12-148 3.1e-28 93.2 In-house 33-170 (515) alignment 
Range on Protein: 12-148
Range on HMM: 33-170/515.0
FDCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYW
.  ..||   |  | | |. || .  || |     | .|||. |||. ..    |.||.||| | .  ||||.|.. .   |.|.|. .|.   .  .||
ypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyW

PVNPNEEDMYGSFNVVALPEDrTLPDYVVRKFKLSHSKN
|  | .   .||..|  .  . .  . . ||... ....
PdkpgdsvkfGsikvelvsle.actggikrkltvlkgdd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 20-147 2.2e-27 91.0 In-house 49-172 (297) alignment 
Range on Protein: 20-147
Range on HMM: 49-172/297.0
SDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQrsAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEeQSVQYWPVNPNEEd
  |. ||| |  || .  || |   | |  |||. ||.| |...   .|.|| |||.|  |||.||.. .  .|.||.. .|. . .  .||. .   . 
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.

mYGSFNVVALPEDRTlPDYVVRKFKLSHSK
 .|.  || |  ..    .. |.......|
.fGdvsvvllsvser.eGfikrelevtkgk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 11-146 1.2e-26 88.3 In-house 22-155 (283) alignment 
Range on Protein: 11-146
Range on HMM: 22-155/283.0
DFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYdsDYICASYVD---GYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQ
| |. ||  ..|  | | .| .| . .|| | ...   ||| |...     |.|   .|..|.|...|  |||.||.. |   |.|||.  |. ...  |
dldadiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPVNPNEEdmYGSFNVvALPEDRTLPDYVVRKFKLSHS
||| .  |.  || | | .| .. |   ...... | ..
yWPkrGsed..yGeftv.tlrkettsnsfiikelllrvn
subfamily_PTPN1_pd Subfamily PTPN1 10-146 2.5e-26 87.1 In-house 20-156 (290) alignment 
Range on Protein: 10-146
Range on HMM: 20-156/290.0
DDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKnyDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYW
.||... |.|  | .. | ..  | .  |..|  .  | ||| || |.  . .  .| ||||. ||.. ||.|||| ||  ..|| .  |... . .|||
sdfptreaklpenrnlnryrdvspydhsriklera..dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PVNPNEEDMYG---SFNVVALPEDRTlPDYVVRKFKLSHS
| . .|. .     ...|  . |.|.   |.||...|   
Pqgeeekellledtklkvkliseerk.syytvrllelenl
subfamily_PTPRN_pd Subfamily PTPRN 13-145 3.5e-26 86.6 In-house 47-180 (297) alignment 
Range on Protein: 13-145
Range on HMM: 47-180/297.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVD-GYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYW
 ...|.  .|. | |.|. || .. || |....   .|||| || .     ...|.||||||. .|  |||.||||  ...|..||. ||.| .|  .||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PVNpnEEDMYGSFNVVALPEDRTLPDYVVRKFKLSH
| .   ...|. ..|  . |     ||.|| | |  
pde..Gsevyhiyevhlvsehiwcddylvrsfylkn
subfamily_PTPN13_pd Subfamily PTPN13 13-147 1.9e-25 84.7 In-house 28-161 (273) alignment 
Range on Protein: 13-147
Range on HMM: 28-161/273.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYdsdYICASYVDGY--RQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWP
.|....  .| .| | .. || .. || |. .     || ||..      ..  .||.|||. .|. |||.|||| |. .|.|.|.  |.|. .  .|||
tcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

VNPNEEDMYGSFNVVALPEDRTLPDYVVRKFKLSHSK
.. |.. .  .   |.| .   | ..|||......|.
esknkklkvsnrlevellkvqkldgfvvralavkdse
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 17-145 2.4e-25 84.0 In-house 15-147 (270) alignment 
Range on Protein: 17-145
Range on HMM: 15-147/270.0
AQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQ-RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNP
 .   . .  | .. ||    ||.|.. . |  . || | || |. . . ..||..||...|  .||||.|| |.  |.|.|. ||.| ..  .||| .|
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

NE--EDMYGSFNVVALPEDRTlPDYVVRKFKLSH
.|  . ..|  .|.|| | ..   |.... .| .
kekvkledgkikvlalseeke.egyiltrlrlee
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 21-147 1.3e-24 81.7 In-house 2-127 (237) alignment 
Range on Protein: 21-147
Range on HMM: 2-127/237.0
DNLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQ-RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPvNPNEEDMY
.| .|.|  .    .  ||||     .|||| |.|..|.      .||.|||....  |||.|||. |  .|.|||   |. |..  .||| . ..   |
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaay

GSFNvVALPEDRTLPDYVVRKFKLSHSK
| .  |.|  .  . || || . ||.  
gvlt.vslkkkeefsdytvrslllskrl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 8-147 1.8e-24 81.0 In-house 32-167 (439) alignment 
Range on Protein: 8-147
Range on HMM: 32-167/439.0
TDDDFDCS--IAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEe
|. |. |   .|  . . .| | |.  . .  ||.|        | || | |..|| .   .|||||| |.|. ||||.|.| |.. |.||||  |    
tspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.

qsvqYWPVNpnEEDMYGSFnVVALPEDRTLPDYVVRKFKLSHSK
    ||| .  .| .||   .|    .  ||.||.| ||.   .
....ywpsd..aevcygdi.avrvdrnielpnyvirgfkvfner
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 6-125 1.3e-22 75.0 In-house 19-131 (267) alignment 
Range on Protein: 6-125
Range on HMM: 19-131/267.0
SPTDDDFDCSIAqlSDNLAKSRVKEHLPPNDYRVVLSTKNYDsdYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTeenGEEQS
|.|     .|||  ..| .. |. . || .| ||.|.||. .  || ||||.||... |||.||.|.||| .||. .. . |  .|..||..   .... 
sdtsstisqsia..eknqernrlddnlpyddtrvilrtkeee..yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdni

VQYWPVNPNEEDMYGSFNVV
 ..|| .  .   |  . | 
rlfwPPkmgqakkyqdltve
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 12-131 2.7e-22 73.8 In-house 46-162 (290) alignment 
Range on Protein: 12-131
Range on HMM: 46-162/290.0
FDCSIAQLSDNLAKSRVKEhLPPNDYRVVLSTKNYDSDYICASYVDGYRqrSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPV
.. .| .   .. | | |. .. ||   |.    || ||. | ||.| .  . || |||..|.|. |.|||| . |   |.|| .  |.|  .  ||.| 
lerkifdkntefkknrykd.vvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype

NPNEEDMYGSFNVVALPEDR
.  |   .|.. |.   || 
keGevltfGeitvlcseedd
subfamily_egg_pd Subfamily egg 19-141 6.9e-22 72.5 In-house 37-162 (307) alignment 
Range on Protein: 19-141
Range on HMM: 37-162/307.0
LSDNLAKSRVKEHLPPNDYRVVLSTK--NYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENgeEQSVQYWPVNPNEE
 ..|| |.| |     .  || |  .   |  |.| | .|.|      || .| |.|||  ||||||.. .   |.||| . |.  |.   |||  ... 
sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

DMY--GSFNVVALPEDR-TLPDYVVRKF
 ..  ||... .|  |. . | . | |.
lvtvpGslrienlkvdskadplfrvtkl
subfamily_ptpA1_pd Subfamily ptpA1 18-121 8.6e-22 72.4 In-house 43-149 (418) alignment 
Range on Protein: 18-121
Range on HMM: 43-149/418.0
QLSDNLAKSRVKEHLPPNDYRVVLST--KNYDSDYICASYVDGYRQRsAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNE
.   | .| |  . || |  || |     .  |||| | |.||   .  ||.||||. ||  |||||||| .  ||.||.   ||   .  .||| .   
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

ED--MYGS
|.  .|| 
eqfsiygn
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 7-108 2.2e-21 70.7 In-house 30-137 (392) alignment 
Range on Protein: 7-108
Range on HMM: 30-137/392.0
PTDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVL--STKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQ
|  | .. ..||  .|| | | |. || .  ||.|       ||||. |||.... .  |.||.|||   .  ||||||.. .   |.|.|. .|    .
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgd

----SVQY
      |.
dartvaqf
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 22-146 3.8e-21 70.3 In-house 8-131 (239) alignment 
Range on Protein: 22-146
Range on HMM: 8-131/239.0
NLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQ-RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPvnpNEEDM
| || |  . .  .  ||||   .    |||| |||.  |     |.||||| .. ..||||||.|. .  .|.|||   |  ...  ||||   .    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstsk

YGSFNvVALPEDRTLPDYVVRKFKLSHS
|  .  |.| .   . ||..| | .|. 
ycnlr.vtlrktevfadyiirtfvmsqv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 22-146 3.8e-21 70.3 In-house 7-130 (239) alignment 
Range on Protein: 22-146
Range on HMM: 7-130/239.0
NLAKSRVKEHLPPNDYRVVLSTKN--YDSDYICASYVDGYRQ-RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPvnpNEEDM
| || |  . .  .  ||||   .    |||| |||.  |     |.||||| .. ..||||||.|. .  .|.|||   |  ...  ||||   .    
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstsk

YGSFNvVALPEDRTLPDYVVRKFKLSHS
|  .  |.| .   . ||..| | .|. 
ycnlr.vtlrktevfadyiirtfvmsqv
subfamily_CG42327_pd Subfamily CG42327 25-125 1.6e-20 68.0 In-house 31-136 (319) alignment 
Range on Protein: 25-125
Range on HMM: 31-136/319.0
KSRVKEHLPPNDYRVVLSTKNYD--SDYICASYVDGYRQR-SAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNP--NEEDMY
|||| . .|  . ||||  .  |  . |. |||| ||..  . .||.| ...... ||||.||| .| .|. ||.  |.| ..  .|.| .   .....|
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

GSFNVV
| . | 
Gdilvt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 15-124 1.5e-19 65.0 In-house 26-137 (297) alignment 
Range on Protein: 15-124
Range on HMM: 26-137/297.0
SIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGY--RQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVN
| |. .  | | | .. |  .| || |     ..||| | ||      .   .| .|||...|  |||..|.|    .|.|... .|.| .. . |||  
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

PNEEDMYGSFNV
 .|    |.. |
vqerlkagdvvv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 19-129 5e-19 63.0 In-house 49-159 (310) alignment 
Range on Protein: 19-129
Range on HMM: 49-159/310.0
LSDNLAKSRVKEHLPPNDYRVVLST-KNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEd
  ... | |  . .  .. || |   |    ||| | ||     ||.|| .|||.. |  |||||... ..  |..| .. |.|  ..| |||     | 
ykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte.

MYGSFNVVALPE
 ||   |  | |
tygcirvtnlse
0049772 (Phosphotyrosine protein) phosphatases II 14-114 6.6e-19 64.2 In-house 38-156 (314) alignment 
Range on Protein: 14-114
Range on HMM: 38-156/314.0
CSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYrqrSAFIATQGPMKNTAGDF----------WRMV--WEMKSMIIIM--------
. .|.|  |  | | .. || . .... .  ...|||| ||||||.    .|||||||...|  ||          ||||  ..... .| |        
ilvadlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LTNTEENGeeqsvqywpvnpN
             |..  .||            |
elsrLdaAlgKtpllildgng............n
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4-111 2.9e-18 60.7 In-house 30-152 (350) alignment 
Range on Protein: 4-111
Range on HMM: 30-152/350.0
SSSPtDDDFDCSIAQLSDNLAKSRVKEHLPPNDYRVVLS-------TK---NYDSDYICASYVDGY----RQRSAF--IATQGPMKNTAGDFWRMVWEMK
|.|   .  |  ...  .  || | |. || .  || |        .|      .||| |.|.       .. . |  ||||.|...|  ||.... . |
sdse.spsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnk

SMIIIMLTNTEENGEEQSVQYWPV
  .|..||.  |.. |.  .||. 
vkvilsltsdvelnlekcyrYWqe
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 18-121 3e-18 60.9 In-house 37-140 (307) alignment 
Range on Protein: 18-121
Range on HMM: 37-140/307.0
QLSDNLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEED
 .| |  | | ..    .  |.|. ..   |||| | |.    .   ||..|||..||  .|| |. . |   .||| .. | .. .  ||||..  .. 
afsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

MYGS
..|.
vfge
0041856 (Phosphotyrosine protein) phosphatases II 22-117 6.6e-18 60.4 In-house 1-73 (182) alignment 
Range on Protein: 22-117
Range on HMM: 1-73/182.0
NLAKSRVKEHLPPNDYRvvlstknyDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTnteengeeqSVQYWPvnpneeD
|| | |... ||..  |        |.||| |....|..  . |||||||...|  ||.||..|..  .|..||         ...|||      .
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp......e
0051429 (Phosphotyrosine protein) phosphatases II 48-146 2.1e-16 55.9 In-house 4-113 (272) alignment 
Range on Protein: 48-146
Range on HMM: 4-113/272.0
SDYICASYVDGYRQ---RSAFIATQGPMKNTAGDFWRMvWEMKSMIIIMLTNTEENGEEQSVQYWP---------VNPNEEDMYGSFNVVALPEDRTLPD
|.|| |..|.|| .   . ......||...|| ||||. .|..   |..|...|| | ..  .|||         ..  ....   . .| | .  .|.|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YVVRKFKLSHS
|..|.. |.. 
yilrellltll
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 22-119 4.5e-16 53.3 In-house 53-152 (305) alignment 
Range on Protein: 22-119
Range on HMM: 53-152/305.0
N--LAKSRVkEHLPPNDYRVVLSTKNYDSDYICASYVDGYR-QRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDM
.   .| |  . .| .|  .|.  |   |||| | ||         ||..|||. .|  .|| || . |   |.|| .| | |  .  ||||.   |   
diaitknry.qdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

Y
 
l
0046846 (Phosphotyrosine protein) phosphatases II 38-119 4.5e-16 54.6 In-house 2-76 (176) alignment 
Range on Protein: 38-119
Range on HMM: 2-76/176.0
RVVLSTKNYDSDYICASYVDGYRqrsaFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVnpnEEDMY
|..|.. ..|.||| |....|.|    .||||||. .|  ||..|..|..  ....||.  | |  .  .|||.   .|.. 
rlrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklg
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 39-124 7.6e-16 52.6 In-house 58-142 (281) alignment 
Range on Protein: 39-124
Range on HMM: 58-142/281.0
VVLSTKNyDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNV
| .  ||  .||| | |.     .  .| |||| |.|  |||||.|. ..  |.|| .  |   |.  .|.| |      .  . |
vkmpnkn.stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsv
0036282 (Phosphotyrosine protein) phosphatases II 48-122 1.3e-15 53.0 In-house 2-71 (174) alignment 
Range on Protein: 48-122
Range on HMM: 2-71/174.0
SDYICASYVDGYRQRSAFIATQGPMKntagdFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSF
|||| ||..|...  . .||.|||..     ||.|..| .. ...||.. .|.| .   .||| ... .  .|  
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 62-145 3e-15 50.9 In-house 4-86 (199) alignment 
Range on Protein: 62-145
Range on HMM: 4-86/199.0
RSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALpEDRTLPDYVVRKFKLSH
.  .|||| |...|  |||.||||  |  |.|. . . | | .   |||.  .    |||..|..     | |||..  . |. 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttk.tittkpdytitaliltn
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 63-145 3.3e-15 50.8 In-house 4-85 (198) alignment 
Range on Protein: 63-145
Range on HMM: 4-85/198.0
SAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALpEDRTLPDYVVRKFKLSH
  .|||| |...|  |||.||||  |  |.|. . . | | .   |||.  .    |||..|..     | |||..  . |. 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttk.tittkpdytitaliltn
0043147 (Phosphotyrosine protein) phosphatases II 47-107 4.1e-15 51.4 In-house 4-55 (172) alignment 
Range on Protein: 47-107
Range on HMM: 4-55/172.0
DSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTeengeeqsvQ
.|||| |||.|.|.    |||||||. ||  |||||..|..  .|..||.          .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........l
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 35-124 4.2e-15 50.5 In-house 48-136 (285) alignment 
Range on Protein: 35-124
Range on HMM: 48-136/285.0
NDYRVVLstKNYDSDYICASYVD-GYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNV
.. ||||  ||.| ||| ||..    ...|..|.||||. .|  |||.|... |   ..||    | | |.   |.| .  |   .| ...
eetrvvl..knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyei
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 32-139 4.9e-15 50.1 In-house 59-166 (301) alignment 
Range on Protein: 32-139
Range on HMM: 59-166/301.0
LPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALPEDR
.| .    |   ..     | | ...   .   |||||||.|||. ||| |.   .   |.||... |. ||.  .| ||...|.   | |..    .. 
vPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkel

TLPDYVVR
 | . ...
ilnkkisk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 23-114 3.4e-14 47.3 In-house 49-139 (305) alignment 
Range on Protein: 23-114
Range on HMM: 49-139/305.0
LAKSRVKEHLPPNDYRVVLsTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPN
  | | |.    .. || |    .  .|| | ||    .   || || |...|  ||| | .. |   |.|| |  | | .. ..|.. . .
agknrykdvgcldnnrvkl.egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdk
0049260 (Phosphotyrosine protein) phosphatases II 55-121 1.6e-13 46.1 In-house 1-56 (152) alignment 
Range on Protein: 55-121
Range on HMM: 1-56/152.0
YVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWpvnpneedmygS
..|||..  .|||||||. ||. |||||..|..  .|.|||. .|.|...  ||.            
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........q
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 21-111 1.2e-12 42.0 In-house 95-180 (244) alignment 
Range on Protein: 21-111
Range on HMM: 95-180/244.0
DNLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEeqsvqYWPV
.|  |.|    || .  || ||  .    || ||.|    . . .| || |. .|. |||.|. | .  ....|   ||. |     ||| 
nnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 57-124 2e-12 41.1 In-house 230-293 (440) alignment 
Range on Protein: 57-124
Range on HMM: 230-293/440.0
DGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEEngEeQSVQYWPVNPNEeDMYGSFNV
.|| .. |||||| |.  |  ||||.| . .   |||| . ..        |||||      .| | |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd..k.tcsiywpvntrs.vtfgpftv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 17-118 3.7e-12 40.9 In-house 38-137 (288) alignment 
Range on Protein: 17-118
Range on HMM: 38-137/288.0
AQLSDNLAKSRVkEHLPPNDY-RVVLStknYDSD-YICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPN
 .  .| .. |  |.||  |. || ||    |.| || |  |   . .  .| .| |.. | . .|.|. |     |.||..  | | |.| .|.|..  
dsfianptrdry.enlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG

EEDM
|.  
ekar
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 21-105 3.9e-12 40.3 In-house 33-118 (332) alignment 
Range on Protein: 21-105
Range on HMM: 33-118/332.0
DNLAKSRVKEHLPPNDYRVVLSTKNYDSDYICASYVDGYRQRSAFIATQGPMKN-TAGDFWRMVWEMKSMIIIMLTNTEENGEEQS
.|.   |.      .  || |. ..   |.  ||.|||| ..||.| .| |... |   ||||| | |  .|... . .|. . ..
nnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_eak_pd Subfamily eak 18-125 6.4e-12 39.5 In-house 48-155 (332) alignment 
Range on Protein: 18-125
Range on HMM: 48-155/332.0
QLSDNLAKSrVKEHLPPNDYRVVLS-TKNYDSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEE
.  ... .  | . .| . | | |. ..     || || ..       .| |  . ..    ||.|| | ||  |..| .  |.. |.| .|.| .  ||
arleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

DMYGSFNVV
  .| ..| 
lkfGildve
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 20-70 2.2e-10 34.6 In-house 46-95 (95) alignment 
Range on Protein: 20-70
Range on HMM: 46-95/95.0
SDNLAKSRVKEHLPPNDYRVVLSTKNyDSDYICASYVDGYRQRSAFIATQG
  |. | |. . .| .  ||||.||  ||||| | .|||| .. ..||.||
eanipknrflnifpydatrvvlttkr.dsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 17-100 3e-10 34.2 In-house 42-121 (303) alignment 
Range on Protein: 17-100
Range on HMM: 42-121/303.0
AQLSDNLAKSRVKEHLPPNDYRVVLStknyDSDYICASYVDGYRQRSAfIATQGPMKNTAGDFWRMVWEMKSMI-IIMLTNTEEN
 |. .|. | |  . .  .  .| ||    || || |||..   .. | | || |.  || |||.|. | |    ...||..| .
nqfvknmdknrfvdvicldhskvkls....dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseyd
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 14-100 4.3e-10 33.6 In-house 29-124 (347) alignment 
Range on Protein: 14-100
Range on HMM: 29-124/347.0
CSIAQLSDNLAKSRVKEHLPPNDYRVVLSTKNYD-------SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLT--NTEEN
.. ..   .|.| | |..   .. ||||| .. .         || ||..     .  .| || |. .|  |||.||  .|   .. .    ..| 
ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdea
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 48-108 1e-09 32.6 In-house 67-127 (312) alignment 
Range on Protein: 48-108
Range on HMM: 67-127/312.0
SDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQY
  || | .|    .   |..||||..||.  ||...  . |  ||.|.   |.| |....|
nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcaky
0051082 (Phosphotyrosine protein) phosphatases II 48-112 1.1e-09 33.6 In-house 3-56 (151) alignment 
Range on Protein: 48-112
Range on HMM: 3-56/151.0
SDYICASYVDGYrqrsaFIATQGPMKntagDFWRMVWEMKSMIIIMLTNTEENGeeQSVQYWPVN
|||| .|||.|.     .....||.     ||.....|..   |..|...||.|     .|.| .
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 46-110 1.6e-09 31.6 In-house 88-154 (349) alignment 
Range on Protein: 46-110
Range on HMM: 88-154/349.0
YDSDYICASYVDGYR--QRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWP
   ||| | |.   |      .|||| |.  |  ||....   .  ... |.. .|.. |.  .|| 
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
0044763 (Phosphotyrosine protein) phosphatases II 36-114 1.8e-09 33.0 In-house 4-75 (178) alignment 
Range on Protein: 36-114
Range on HMM: 4-75/178.0
DYRVVLST--KNYDSDYICASYVDGYrqrsAFIATQGPmkntaGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPN
..||.||.      |||| ||.....     ......|      |......|..   |..||.. |.| ... .||| . .
rtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 47-111 7.8e-09 29.9 In-house 12-71 (130) alignment 
Range on Protein: 47-111
Range on HMM: 12-71/130.0
DSDYICASYVDGYRQRSAFIATQGPMKNTAGDFWRMVWEMKSMIIIMLTNTEENGEeqsvqYWPV
. .|| ||.|    . . .. || |. .|. |||.|. |    ....|   ||. |     ||| 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpd
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 13-132 3.6e-07 23.3 In-house 18-103 (169) alignment 
Range on Protein: 13-132
Range on HMM: 18-103/169.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLS--TKNYDSDYICAsyvdgyrqrsafiatqgpmkntagdfwRMVWEMKSMIIIMLTNTEENGeeqsvQYWP
.  .|.|. | .| |    | |.  || |    ..  |||| |                           ||.||  . .|..| .|..       ..||
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwp

vnpNEEDmYGSFNVVALPEDRT
   . || |     | | |  |
...eked.yqlhpavilgewyt
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 21-112 4.6e-07 23.6 In-house 50-141 (302) alignment 
Range on Protein: 21-112
Range on HMM: 50-141/302.0
DNLAKSRvKEHLPPNDYRVVLSTKNyDSDYICASYVDGYRQRSAFIATQGPMKNTA---GDFWRMVWEMKSMIIIMLTNTEENGEeQSVQYWPVN
.||.|.. .|..|  | ..|  ...   .|..|| |.    .   | .| | ....    .|||||.. |   . .|  .||  .    ...| .
knlkknq.sedvpildsnlvkleae.pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 13-129 4.8e-07 22.8 In-house 17-99 (169) alignment 
Range on Protein: 13-129
Range on HMM: 17-99/169.0
DCSIAQLSDNLAKSRVKEHLPPNDYRVVLS--TKNYDSDYICAsyvdgyrqrsafiatqgpmkntagdfwRMVWEMKSMIIIMLTNTEENGeeqsvQYWP
.  .|.|. | .| |    | |.  || |    ..  |||| |                           ||.||  . .|..| .|..       ..||
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwp

vnpNEEDmYGSFNVVALPE
   . || |     | | |
...eked.yqlhpavilGe
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 36-124 1.2e-06 22.9 In-house 32-132 (290) alignment 
Range on Protein: 36-124
Range on HMM: 32-132/290.0
DYRVVLS--TKNYDSDYICASYVDgYRQRSAFIATQGPMKN-------TAGDFWRMVWEMKSMIIIMLTNTEENGEEQSV----QYWPVNPNEEDMYGSF
. ||||    | . .||| |..|  . .  ..|.|| | ..       |  .|| |. . |.  ..|| . ||. ...|     .| | . .||  .. .
atrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgl

NV
.|
tv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 75-139 8.3e-06 20.1 In-house 40-101 (255) alignment 
Range on Protein: 75-139
Range on HMM: 40-101/255.0
TAGDFWRMVWEMKSMIIIMLTNTEENGEEQSVQYWPVNPNEEDMYGSFNVVALPedrTLPDYVVR
|   |....   |.  ..||.. .|.| |.  .|.|.. .|  ..   ||..     .  | |.|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlr