Gene PTPRD-31 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP086_AA protein Get Run
AqueP086_AA_156-314 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 162-322 6.7e-77 253.3 In-house 128-287 (287) alignment 
Range on Protein: 162-322
Range on HMM: 128-287/287.0
VIKYWATEATeVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSA
  .||..|.. |..|||.|.||||| .. |.||..|.|||.| |....|.||||| |. .|.||..|.||...|||.||||..|||||||||||||||||
cyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsa

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYSNF
||||||||||||||||||||||||||||||||||||||||||.|..||..|||||..||.|
mfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 164-320 8.8e-74 243.0 In-house 135-290 (290) alignment 
Range on Protein: 164-320
Range on HMM: 135-290/290.0
KYWATEATEViFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMF
.||... |.  .||.|||||||| .. |.||..|.||| ..|....|.||||| |...|.||..|.||...|||.||||..|||||||||||||||||.|
qYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavf

CAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
||||||||||||||||||||||||||||||||||||.||.|||.||  |||||. ||
caaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 164-316 1e-40 134.8 In-house 133-286 (305) alignment 
Range on Protein: 164-316
Range on HMM: 133-286/305.0
KYWATEATE-VIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAM
.||... || . |||.|..| .|. .  |.|| ..| .. .    . |.|||.| |  .| ..   ..| ......|.|... .....||||..|||. .
qYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGv

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
|.|    ....|.|.|.|||.|||  | .... ||| .||  ...... .. ..
fiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 168-320 3.2e-38 126.1 In-house 147-300 (301) alignment 
Range on Protein: 168-320
Range on HMM: 147-300/301.0
TEATEVIFGEYSIKLLNEELYDL----YTERTIEIKNKMkggSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMF
|   | .. .. |. ||  ..|     |.||....|...   | ..|.|.|.| |  .| |  .. .|...... ..|.. |   .||||||||.|| ..
tlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvY

CAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
|.   ..  || |||.||||| |. | .||| |.| |||  |..... ||     |.
csvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstya
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 162-317 5.6e-37 122.6 In-house 141-294 (298) alignment 
Range on Protein: 162-317
Range on HMM: 141-294/298.0
VIKYWATEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSA
. ||| .| .|  .|| ...||..| .  .. |......| .  ....|.| . | |  .|. . ....| .|......|...||....|.||. |||| 
yhkywPdegke.tygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFM
 |.|  . ... |.| |.|||||.|  |...||.||| |||. |.|.|. .|||| 
tfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
0046845 (Phosphotyrosine protein) phosphatases II 160-321 5.5e-36 119.8 In-house 95-282 (284) alignment 
Range on Protein: 160-321
Range on HMM: 95-282/284.0
RS----------------------VIKYWATEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEM
|                         .|| .| . ...|.....||.|| .| || ||.|..|.  .|  ..| ....|.|  .|  .  . .| .|...
rmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlv

NKTQRR-SGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYSN
.. ... .|.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||.|||. ..|... || ... . .
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
0050432 (Phosphotyrosine protein) phosphatases II 160-320 1.6e-35 118.4 In-house 148-306 (308) alignment 
Range on Protein: 160-320
Range on HMM: 148-306/308.0
RSVIKYWATE--ATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrrsGNTSIVVHCSDTV
    .|| .|   . ...| ....||.|| .| || ||.|..|. .| | ..| ... |.|.  |  .  ...| .||...|..   ..  ||||||. |
ekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGv

GRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
||.. |.|. . ..  ..|| .|||...|  | |.||.|||.|||. ...... || ... . 
GRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
0051299 (Phosphotyrosine protein) phosphatases II 160-313 5.4e-34 113.4 In-house 132-286 (288) alignment 
Range on Protein: 160-313
Range on HMM: 132-286/288.0
RSVIKYWATeATEVIFGEYSIKLLNEELYDLYTERTIEIKNKM---KGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrSGNTSIVVHCSDT
.   .|| .  . ...|.....||.|| .| || ||.|..|.    ..|  ..| ... |.|  .|  .  ...| .|....| .. ||.  .|||||. 
ekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaG

VGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
|||...|.|. . ..  ..||..||....|  | |.||.|||.|||. ..|..  ||
vgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 159-318 5.8e-34 113.1 In-house 117-282 (297) alignment 
Range on Protein: 159-318
Range on HMM: 117-282/297.0
RRSVIKYWATE-ATEVIFGEYSIKLLNEEL--YDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS-GNTSIVVHCS
|    .|| .|   .. .|.....||..|   .| || ||.|.... ..|  ..| ....|||  .|  .... .| ..|...| .. . ... ..||||
rekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCs

DTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFML
. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||.|||. . |... .| ....
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 162-320 1.9e-33 110.7 In-house 93-249 (250) alignment 
Range on Protein: 162-320
Range on HMM: 93-249/250.0
VIKYWATEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHkVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSA
. .|| .| .| ..|.  ..||..| .  || |.. . .. | ..|. |.|.. . |   |     .|.| .|......|...||. ..|.||  |||| 
yhqywPvekae.kyGdvtvsllskeefadytkrklklskakkaderi.vrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
 |.|  . ... |.| |.|||.|.|  |...|..|.. |||  ..||.. .|||.  |.
afiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
0047943 (Phosphotyrosine protein) phosphatases II 161-313 4.3e-33 110.3 In-house 118-272 (273) alignment 
Range on Protein: 161-313
Range on HMM: 118-272/273.0
SVIKYWATEAT--EVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGsRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS-GNTSIVVHCSDTV
   .|| .|    ....|.....||.|| .| || ||.|..|.  |   ..| ... |||  .|  .  . .| ..|...|... . .|. .|||||. |
kcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGv

GRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
||...|.|. . ..  ..|| .||....|  | |.||.|||.|||. . |..  ||
gRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRD_pd Subfamily PTPRD 162-316 4.5e-33 109.7 In-house 133-284 (564) alignment 
Range on Protein: 162-316
Range on HMM: 133-284/564.0
VIKYWATEAtEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRSA
. ||| ..  .  .||. ..| .|| .  |. ||...|.| .  | ..| |.. | |  .|  .  ...| ......... ....  ||||||  |||. 
chkYWPekg.tetygeltVtleeeeeladyeirtfklkkkksses.reVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
.|..    ... |.|...|..|..|  | |..  ||| |||  |.|... .|...
tfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
0039614 (Phosphotyrosine protein) phosphatases II 157-315 8.5e-33 109.5 In-house 137-291 (297) alignment 
Range on Protein: 157-315
Range on HMM: 137-291/297.0
YFRRSVIKYWATEATevIFGEYSIKLLNEELYDLYTERTIEIKNkmkGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS-GNTSIVVHCSD
.  |   .|| .| .   .|.....||..| .| || ||.|..|   .|  ..| ..| |||  .|   ... .| .||.... .... ... ..||||.
elgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsa

TVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDS
 |||...|.|| . .. ...|| .||....|  | |.||.||| .||. ...... .|  
GvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0040438 (Phosphotyrosine protein) phosphatases II 160-316 1.2e-32 108.8 In-house 126-279 (317) alignment 
Range on Protein: 160-316
Range on HMM: 126-279/317.0
RSVIKYWATeATEVIFGEYSIKLLNEELYDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrSGNTSIVVHCSDTVGR
.   .|| .  ... .|.....||.|| .. .| ||.|.... ...  ..| ... |||   |    .. .| .||.... .. .... ..||||. |||
ekcaqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgR

SAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
...|.|| . .. ...|| .||....|  | |.||.||| |||. . .... ||  .
tGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0045450 (Phosphotyrosine protein) phosphatases II 162-313 3.3e-31 104.6 In-house 149-304 (307) alignment 
Range on Protein: 162-313
Range on HMM: 149-304/307.0
VIKYWATEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS-GNTSIVVHCSDTVGRS
  .|| .| .|. .|.. ..||.|| .| || ||.|.... . |  ..| ... |||   |  .  . .| ..||..| .... ... ..||||. |||.
caqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRt

AMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
..|.|| . .   ..||.   .|.....|  | |.||.||. |||. . |... .|
GtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 159-321 3.9e-31 103.3 In-house 128-288 (318) alignment 
Range on Protein: 159-321
Range on HMM: 128-288/318.0
RRSVIKYWATEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVG
.. | .||  . ..  .|.  ..| .|  .. |. |....... .  || .| ||..| |  .|  .    .| .. . .|.|..||.. ||||||  ||
kakvhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrteeeesr.qvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvG

RSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYSN
|  .|.|  . ... | |...||||. |  | |..  ||| .||. |..... .| |. .. .
rtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
0042113 (Phosphotyrosine protein) phosphatases II 161-313 6.4e-31 103.0 In-house 93-243 (245) alignment 
Range on Protein: 161-313
Range on HMM: 93-243/245.0
SVIKYWATeATEVIFGEYSIKLLNEELYDLYTERTIEIKNkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRS
   .|| .  ... .|.....||.|| .| || ||.|..| .. .  ..|..|. ..|. .|. . .. .| .||...| .....|. ..||||. |||.
kcaqywpl.gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt

AMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
..|.|| . ..  ..|. .......|  | |.||.||| .||. . |... .|
GtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 160-312 1.4e-30 102.1 In-house 128-276 (278) alignment 
Range on Protein: 160-312
Range on HMM: 128-276/278.0
RSVIKYWAteATEVIFGEYSIKLLNEELYDLYTERTIEIKNkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrSGNTSIVVHCSDTVGR
    .||    . . .|.....||.|| .| || ||.|..| .. |  ..|..|. .||  .|  .  . .| .|..... .. . |. ..||||. |||
vkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgR

SAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
...|.|. . ..  ..|| .|.....|  | |.||.||| .||. ..|... |
TGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
Y_phosphatase Protein-tyrosine phosphatase 159-309 3.1e-30 100.7 Pfam-A 81-233 (235) alignment 
Range on Protein: 159-309
Range on HMM: 81-233/235.0
RRSVIKYWA-TEATEVIFGEYSIKLL-NEE-LYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSD
|. . .||  .| ... .|.....|  .|.   . || |..|.|.| .   ...| |...|.|. .|  .. ...| ......|.. .. ....|||||.
rekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsa

TVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
 |||...|.|. . ......|. .||.|..|. | |.||.||..|||. . ...
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 159-309 3.1e-30 100.7 In-house 81-233 (235) alignment 
Range on Protein: 159-309
Range on HMM: 81-233/235.0
RRSVIKYWA-TEATEVIFGEYSIKLL-NEE-LYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSD
|. . .||  .| ... .|.....|  .|.   . || |..|.|.| .   ...| |...|.|. .|  .. ...| ......|.. .. ....|||||.
rekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsa

TVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
 |||...|.|. . ......|. .||.|..|. | |.||.||..|||. . ...
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 162-309 3.1e-30 100.0 In-house 117-262 (283) alignment 
Range on Protein: 162-309
Range on HMM: 117-262/283.0
VIKYWATEATEViFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWepngEVTCHQAILMI---LEEMNKTQRRSGNTSIVVHCSDTVG
  .||  . .|  .||. . | .|   . .. . . ....    |   .  ||. .|         |||.     .. .   |..| .. |||||| ..|
CsqyWPkrGsed.yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiG

RSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
|.|.|.||...... .|| |.|||.|.|  | |... ||| .||| . |.|
rtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
DSPc_SM00195 158-312 4.5e-30 100.2 In-house 107-261 (263) alignment 
Range on Protein: 158-312
Range on HMM: 107-261/263.0
FRRSVIKYWATEA-TEVIFGEYSIKLLNEELYD-LYTERTIEIKNKMKgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSgNTSIVVHCSD
 .. . .||  |. ..  ||..|.|| ..| ..  .. ||.|.... |    .|| |||...|. .|    .. .| .|....|....| .. ||||||.
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsa

TVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
 |||...|... . ..|...|  .|.|...|. | |.||.||| |||. | |..  |
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 158-312 4.5e-30 100.2 In-house 107-261 (263) alignment 
Range on Protein: 158-312
Range on HMM: 107-261/263.0
FRRSVIKYWATEA-TEVIFGEYSIKLLNEELYD-LYTERTIEIKNKMKgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSgNTSIVVHCSD
 .. . .||  |. ..  ||..|.|| ..| ..  .. ||.|.... |    .|| |||...|. .|    .. .| .|....|....| .. ||||||.
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsa

TVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
 |||...|... . ..|...|  .|.|...|. | |.||.||| |||. | |..  |
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0045098 (Phosphotyrosine protein) phosphatases II 160-313 1.5e-29 98.7 In-house 104-272 (278) alignment 
Range on Protein: 160-313
Range on HMM: 104-272/278.0
RSVIKYWATeATEVIFGEYSIKLLNEELYDLYTERTIEIKNK---MKGGSRHKVVQYQITGWEPNGEVTCH--QAILMILEEMNKTQR------------
    .||      ...|.....||.|| .| || ||... |     ...  ..| ......|. .|  . .  . .| .||.... ..            
ekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

RSGNTSIVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVEQYKGIFEIVQIYL
 .... ..||||  |||.....|| . .  .  ||..|.....|  | |.|| .||. |||. ..| .. .|
ldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 163-316 3.8e-29 96.8 In-house 134-286 (319) alignment 
Range on Protein: 163-316
Range on HMM: 134-286/319.0
IKYWATEATeVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAM
 ||| .|   . .|.. ..|..||  . |  | .....|       .|...| | |  ..  .  ...| .|....|..... .  ||||||. |||   
kkywpeenf.eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGt

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
|..   .... | |||.|||.. .  |.|..  ||. |||| |.|..  .....
fivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
0040439 (Phosphotyrosine protein) phosphatases II 159-313 1.6e-28 95.4 In-house 93-246 (249) alignment 
Range on Protein: 159-313
Range on HMM: 93-246/249.0
RRSVIKYWATeATEVIFGEYSIKLLNEELYDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS-GNTSIVVHCSDTV
|    .|| .  ... .|.....||..| .| || ||.|..|. . |. ..| ..|.|.|   |     . .| ..|...| ...   .. ..||||. |
rekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGv

GRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
||...|.|| . ..  ..|. .|.....|  | |.||.||. |||. . |... .|
gRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPRK_pd Subfamily PTPRK 158-309 2.7e-27 90.4 In-house 124-273 (314) alignment 
Range on Protein: 158-309
Range on HMM: 124-273/314.0
FRRSVIKYWAtEATEViFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHK-VVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRsGNTSIVVHCSDT
.|   .|||  | ||| .|.  ..|.. ||   .  |.  ...  .| . .. | |.| .||   .  .  ...| .. ...|.|   ..  ||||||  
grvkClkyWP.edtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaG

VGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
 ||. .|.| .. ..  ..|||.|||.. |. | .|.  |.| |||| |....
aGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPRA_pd Subfamily PTPRA 163-312 3.3e-27 90.2 In-house 144-294 (330) alignment 
Range on Protein: 163-312
Range on HMM: 144-294/330.0
IKYWATEATeVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGG---SRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNtSIVVHCSDTVGR
 .|| .| . | .|.  ... .|..   || | . .... ..    .   | |.  |.|   |  .  . .| .|....|....|.. .||||||  |||
aqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGr

SAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
.  |..  . ... |.|...|||...|. | |.|  ||| |||. |..... |
tGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 160-309 3.7e-27 90.1 In-house 132-275 (315) alignment 
Range on Protein: 160-309
Range on HMM: 132-275/315.0
RSVIKYWATEatEVIFGEYSIKLLNEELYDLYTERTIeikNKMKGGSRHKVVQYQITGWePNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGR
| . |||  .  .||.|.... . .|| .. || ||.     . |   ..|||...| | |. .|. .   || |    |  . .  ..||||||. |||
rkaekywpdk..kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytsw.pdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGr

SAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
.  |..  . ... ..| .|||.....  | .. . ||..|||. |....
tGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Ptp69D_pd Subfamily Ptp69D 159-308 6.4e-27 89.5 In-house 130-281 (307) alignment 
Range on Protein: 159-308
Range on HMM: 130-281/307.0
RRSVIKYWATEaTEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGG----SRHKVVQYQITGWEpNGEV-TCHQAILMILEEMNKTQRRSgNTSIVVHC
|. . |||. | .|| .|.  .|| .||  . |..|.... .| . .     ..|||||. |||. . .|  . ...| ..|.... .. . .. |||||
rkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykln.rsPivvhC

SDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEI
|  ||||..| | .  ....|.|  .|.|.. |  | |..  ||  |||. ..  
saGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyra
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 162-310 2.9e-26 87.2 In-house 132-276 (288) alignment 
Range on Protein: 162-310
Range on HMM: 132-276/288.0
VIKYWATEATEVIFGEYSIKLLNEELYDLYTERTIEIKnkmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRSA
 ..|| .. ... .|.  ..|....  . ...|.....   | ... .. ||| ..|  .|    .. .| .|. .. ..  .    |.||||. |||. 
CeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvan.qadtgpiivhCsaGvGrtg

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
 | |. . |.. ..| .|||. ...  | |..  |||..||  |.|.. 
tFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN6_pd Subfamily PTPN6 162-314 6.2e-26 86.1 In-house 140-298 (306) alignment 
Range on Protein: 162-314
Range on HMM: 140-298/306.0
VIKYWATEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSG---NTSIVVHCSDTVG
 ..|| .| ..  .|..|.. ..|.  . |. |.. ...| |... ..|.||. . |  .|  .  .|.|  ||..|. |...    . .||||||. .|
CarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiG

RSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
|   |    . ... ...|.   ||. .. || | |. | ||| .||| ...... |..
RtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
0037934 (Phosphotyrosine protein) phosphatases II 162-312 7e-26 86.7 In-house 90-241 (243) alignment 
Range on Protein: 162-312
Range on HMM: 90-241/243.0
VIKYWAteaTEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRR-------SGNTSIVVHCS
. .||     || .|.....||.|| .| || ||....|.  ..  . |..|. ..|  .|  . .. .| .|.|... ...       ...  ..||||
caqywp...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

DTVGRSAMFCAAATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTVEQYKGIFEIVQIY
  |||.....|| . . ..   | .|.....|  | |.|| .||| .||. . |... .
aGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 161-314 2.2e-25 84.2 In-house 128-278 (315) alignment 
Range on Protein: 161-314
Range on HMM: 128-278/315.0
SVIKYWAT-EATEVIFGEYSIKLLNEELYDLYTERTIEIKnkmKGGSRHKVVQYQITGWEPNGEVTcHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGR
.  .||   .|  | ||.....||. |     . | . ..   |. . ..| |.| |.|  .|    ... |. |    |..... . |..||||  |||
kcrqywPdrkadsvefGsikvellsleadtdgvarklvtr...kseesrtvtqfqftewPdkGvdk.qtssllklikevkadngkkefsllvhcsaGvGr

SAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
. .....   ... | . ..|||...|  | ..|  ||| |.|  |...|. .| 
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPRG_pd Subfamily PTPRG 159-310 4.9e-25 82.8 In-house 130-284 (563) alignment 
Range on Protein: 159-310
Range on HMM: 130-284/563.0
RRSVIKYWATeATEVIFGEYSIKLLNEELYDLYTERTIEIKN-KMKGGSR----HKVVQYQITGWePNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHC
||    || .  . . .|. ...| .||   |||.||. ||| |.| ...    ..| ||. | | |.  |  |..  .|  . ... ...    |||||
rrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkW.PdhgvPehslpvLifvkkssaankaeaGPivvHc

SDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
|  |||. ....  | ... ..| ...||..||  | |..  ||| |||  ......
saGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 160-315 2e-24 81.3 In-house 131-286 (297) alignment 
Range on Protein: 160-315
Range on HMM: 131-286/297.0
RSVIKYWATEATEViFGEYSIKLLNEELYDLYTERTIEIKnKMKGGSRHKVVQYQITGWEPNGEVT--CHQAILMILEEMNKTQRRSGNTSIVVHCSDTV
..  .||. ...   ||. |..||  .    . .|..|.. | |  .|. | ||| . |  . .      ...| ...|..|.     .. ..|||.  |
kkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevt.kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGv

GRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDS
|| .....    . . | |  .|.|...|  | ..|  ||| |||| ....|  .| |
Grtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 163-313 2.7e-24 80.2 In-house 129-276 (515) alignment 
Range on Protein: 163-313
Range on HMM: 129-276/515.0
IKYWAT-EATEVIFGEYSIKLLNEELYDLYTERTIEIknkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMnKTQRRSGNTSIVVHCSDTVGRSA
 |||    .  | ||.....|.  |     . |....   .||   . | |.. |.|  .|     ...| .. |. |...   . ....|||  |||  
gkyWPdkpgdsvkfGsikvelvsleactggikrkltv...lkgddsrtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
.....   . . ||  ..|||....  | ..|  ||| |||  |...|. .|
vvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPN12_pd Subfamily PTPN12 162-313 2.3e-23 77.5 In-house 125-277 (290) alignment 
Range on Protein: 162-313
Range on HMM: 125-277/290.0
VIKYWATEATEVI-FGEYSIKLLNEELYD-LYTERTIEIKNKmkgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrSGNTSIVVHCSDTVGR
  .||. |  | . |||....| .|.  |  .. ||......   . ..|| |.. | |   |  . .. .| ..|.....|. | .. .|||||  |||
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGr

SAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
    .|   . .  |.| .   .|||... . | |..  ||| |||. ... |  ..
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPRB_pd Subfamily PTPRB 164-313 3.6e-23 77.0 In-house 138-285 (293) alignment 
Range on Protein: 164-313
Range on HMM: 138-285/293.0
KYWATEATEVIFGEYSIKLLNEELYDLYTERTIEIKNkmkGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQ-RRSGNTSIVVHCSDTVGRSAM
.|| .. ..|..|. ...|..|| .. .. |...|..   . ...|| ||. | |   |     ...| ......... . . .. ||||||  |||.  
eYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGt

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
| |  . ... ..| ..|.| .. . | ..   |||..||  | . |. .|
fialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 161-310 6.5e-23 76.4 In-house 131-285 (325) alignment 
Range on Protein: 161-310
Range on HMM: 131-285/325.0
SVIKYWATE-ATEVIFGEYSIKLLNEELYDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNK---TQRR--SGNTSIVVHCS
.  .||  | .  . ||   .||   | .  |  | ...|.  |.|    | |.|. .|.  |      ... ||. ...   . .    . | |.||||
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqv.kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

DTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.||.||  |.| . 
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 164-315 1e-22 75.6 In-house 128-278 (281) alignment 
Range on Protein: 164-315
Range on HMM: 128-278/281.0
KYWATEATEVIFGEYSIKLLNEELYDLYTERTIEIknKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMF
.||  ...|...|.. .| ..||    | ||....  ....|   .|.| . | |  .|  .  ...|   .|..|..... ....|.|||  |||.  .
rYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGty

CAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDS
 |  . ......|   .|| .|... | ..   |||| ||. .. .|  .|| 
ialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
PTPc_DSPc_SM00012 209-307 2.4e-22 74.5 In-house 1-101 (105) alignment 
Range on Protein: 209-307
Range on HMM: 1-101/105.0
KVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
.| .|..|||   |  .  ..|| .|....| .. |. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| |||  . 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

E
.
r
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 195-309 5e-22 73.2 In-house 143-255 (267) alignment 
Range on Protein: 195-309
Range on HMM: 143-255/267.0
TIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILmiLEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPG
 | .. |.|  | |.|. |    |. | .   .   |  .  . | |   ||  .||.||| ||||  |  . . ... ||||| |.|. |.  | |..|
iitlelkfknesahnvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqrig

SVQTVEQYKGIFEIV
 |.| |.|  | |..
lvdtkeryiyihell
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 160-307 4e-21 70.7 In-house 102-249 (284) alignment 
Range on Protein: 160-307
Range on HMM: 102-249/284.0
RSVIKYWATEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEE-MNKTQRRSGNTSIVVHCSDTVG
    .||  .. .   ... .|.   |  . |. | ||. .. |     |. |. . ||   |       ......     |..  ....||||||  ||
dkcsqywplkivi.keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvg

RSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
|. .. .  . ... | |  .||.....  | |..  || . ||| |. 
rtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 161-307 4.3e-21 70.5 In-house 139-285 (319) alignment 
Range on Protein: 161-307
Range on HMM: 139-285/319.0
SVIKYWATEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEE-MNKTQRRSGNTSIVVHCSDTVGR
   .||  .. .   ... .|.   |  . |. | ||. .. |     |. |. . ||   |       ......     |..  ....||||||  |||
kcsqywplkivi.keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGr

SAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
. .. .  . ... | |  .||.....  | |..  || . ||| |. 
tGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
0051429 (Phosphotyrosine protein) phosphatases II 158-317 4.8e-21 71.1 In-house 52-229 (272) alignment 
Range on Protein: 158-317
Range on HMM: 52-229/272.0
FRRSV-------IKYWA-----------TEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTchQAILMILEEMNK
.|. .        .||.           ..|... .| ....|| |||.. |. |......... |  ..| ... |.|   |  .  .|.| .||....
LrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld

tqrrsgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------VFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFM
      .  ..||||  ..|.....|.   .     | ..|        ......  | | ||.||| |||. ..|... .|.|..
......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsll
subfamily_PTPN9_pd Subfamily PTPN9 159-308 6.6e-21 69.6 In-house 124-285 (297) alignment 
Range on Protein: 159-308
Range on HMM: 124-285/297.0
RRSVIKYWA-TEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS------------G
|.   .||  .| .   ||..|.. .. | .. |..|..||||  .. || ||. .|...|   |     ...| .||.. ..|  .             
rlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesr.kvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghps

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEI
.  ||||||  .||.  |..   .... ...|..||....|  | |.  |.|| |||.  .  
gPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla
subfamily_PTPN3_pd Subfamily PTPN3 161-314 2.3e-20 67.7 In-house 125-277 (280) alignment 
Range on Protein: 161-314
Range on HMM: 125-277/280.0
SVIKYWATEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKtQRRSGNTSIVVHCSDTVGRS
   .|| ..  |. .||.|.|. .|.    |  | . .|.| .  .| |..| | . |  .|  . .. .| ..|...| .|.. .. .|||||  .||.
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeer.kilqlqylaWpdhgvPddsadflefvervrk.lrsgkeePvvvhCsaGigrt

AMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE-IVQIYLD
 .. .  |.. .  ..  . . ....  | |.   |||..||| . | |...| .
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_CG7180_pd Subfamily CG7180 154-312 4.4e-20 66.5 In-house 118-289 (296) alignment 
Range on Protein: 154-312
Range on HMM: 118-289/296.0
QIFYFRRSVIKYWATEAtEVIFGEYSIKLLNEELYDLYTERTIEIKNK-------MKGGS--RHKVVQYQITGWEPNGEVTCH-QAILMILEE----MNK
. | |.. . .||  .. .  .||  .....|. |   . ||. .. |       .|. .     | ..|.| || . .|    .|.. ...     ..|
ktfdfakmypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrek

TQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
.. .  .  .||..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..||.|| |..... .
vdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
0036282 (Phosphotyrosine protein) phosphatases II 168-306 9.4e-20 66.5 In-house 60-163 (174) alignment 
Range on Protein: 168-306
Range on HMM: 60-163/174.0
TeatevifgeysikllneelydlytertieiknkMKGGSRHKVVQYQITGWEPNGEVTCHQaILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAA
.                                 ..   .. ..||. ..|. .|. . .. .| ....... . ....  ..||||  |||.....|| 
e.................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaay

TTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
  .   . |...|........| |.||.||| .||. . 
lmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 163-314 2e-19 64.7 In-house 116-269 (274) alignment 
Range on Protein: 163-314
Range on HMM: 116-269/274.0
IKYWATEATEV---IFGEYSIKLLNEELYDLYTERTIEIKNKMKggsRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNT--SIVVHCSDTV
 .|. ..        .|. .||  .    . |. |.. .|.  .   ...|. |  | |  .      ...| ...|........ .   ..|||||  .
avyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGi

GRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
||  .| |.  .... . |.|.||...    |... | ||| |||. |....  || 
GrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN23_pd Subfamily PTPN23 158-310 3.4e-19 63.7 In-house 121-277 (288) alignment 
Range on Protein: 158-310
Range on HMM: 121-277/288.0
FRRSVIKYWATEAT-EVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNK---TQRRSGNTSIVVHC
.. .| .|| ..    | ||..|. | ...  . . ||..... . .    ..|.  |.| |   |     . .| .|.|...   ...|  .| .||||
gkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhC

SDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
|  |||. .|.   . ... .  .|..|. ||..  | |.  .||..||.|  .|.| 
saGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 164-314 1.6e-18 61.7 In-house 108-265 (270) alignment 
Range on Protein: 164-314
Range on HMM: 108-265/270.0
KYWATEATE---VIFGEYSIKLLNEELYDLYTERTIEIKnkmKGGSRHKVVQYQITGWEPNGEVTCHQ------AILMILEEMNKTQRRSGN-TSIVVHC
.||..|. |   . .|. ..  |.||  . |  . ....   . |.....| .. . |  .| .. ..       .| .|... .....  . . ..|||
rYWpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

SDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
|. |||. .. |  ....  .... .|| ....  | ...  ||..|||. ... |..| .
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_PTPN13_pd Subfamily PTPN13 164-309 4.6e-17 57.2 In-house 121-265 (273) alignment 
Range on Protein: 164-309
Range on HMM: 121-265/273.0
KYWATEATEV--IFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrsGNTSIVVHCSDTVGRSA
.||  .. .   . . . ..||. . .| .. |....|..  | | ..|.. . . |   |  .  . .| .. |... |.   .. ||||||  .||| 
rywPesknkklkvsnrlevellkvqkldgfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
.. .  . ..  . .  .|| ..... | |. | ||| .||  .....
tlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_PTPN1_pd Subfamily PTPN1 163-303 4.9e-17 56.6 In-house 114-261 (290) alignment 
Range on Protein: 163-303
Range on HMM: 114-261/290.0
IKYWATEAT--EVIFG--EYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGN-TSIVVHCSDTV
 .|| ..    |...   ....||..|| .. || |..|..|.    .| .....  | |   |   . .| |  | .. ..   | .    |.|||  .
aqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetr.eilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYK
|||  || . | .    | .    .|. .||   | .. | .|| .| .
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlr
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 163-307 1e-16 55.9 In-house 88-233 (237) alignment 
Range on Protein: 163-307
Range on HMM: 88-233/237.0
IKYWATEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEM-NKTQRRSGNTSIVVHCSDTVGRSA
 |||        .| ... |  .| .  || |.. . ....      . |||.| |  .|      |.| .  .. |...  |  .  ..|||  |||..
hkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtg

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
.|    . . ..| . |.|... ..|   ..|  .|| .||  |..
iflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 198-314 1.1e-16 55.3 In-house 268-386 (392) alignment 
Range on Protein: 198-314
Range on HMM: 268-386/392.0
IKNKMKGGSRHKVVQYQITGWEPNGEVT--CHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGS
.|.  .  . | | |||. ||   |       ...| ..  .  .  .  . ||.|||    ||. .||.|   | .      .|.|| .|  | ..  .
lkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqf

VQTVEQYKGIFEIVQIYLD
||| |.|  ...... || 
vqteeeyafvydvireylh
subfamily_PTPRN_pd Subfamily PTPRN 162-309 1.2e-16 55.3 In-house 142-288 (297) alignment 
Range on Protein: 162-309
Range on HMM: 142-288/297.0
VIKYWATEATEViFGEYSIKLLNEELY-DLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRsGNTSIVVHCSDTVGRS
. .||  | .|| .. | ..|. | .. | |  |.. .||  .  .|  | |.    |. .|  .  ...|     .||. |    ..||||||| .||.
ckrywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetr.tvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrt

AMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
 ....    .|.  |    ||.   |.  | |.|| |.| .|.. ..  |
GvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
0043147 (Phosphotyrosine protein) phosphatases II 203-306 5e-16 54.4 In-house 58-154 (172) alignment 
Range on Protein: 203-306
Range on HMM: 58-154/172.0
KGGSRHKVVQYQITGWEPNGEVtCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVEQ
. .  . ..||. ..|. .|     . .| .|| ... . .| .  ..||||  |||.....||   .        . .......  | ..||.||. .|
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsq

YKGIF
|. . 
yrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 202-309 8.2e-16 52.3 In-house 83-190 (440) alignment 
Range on Protein: 202-309
Range on HMM: 83-190/440.0
MKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQ
..|   . . ||.  ||  .|       .| .....|..| ..||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| ||
ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeq

YKGIFEIV
|  ..| |
yafvheav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 158-314 3.6e-15 50.5 In-house 118-279 (287) alignment 
Range on Protein: 158-314
Range on HMM: 118-279/287.0
FRRSVIKYWATEATEVIFGEYSIKLLNEELY-DLYTERTIEIKNkMKGGSRHKVVQYQITGWePNGEVTCH--QAILMILEE---MNKTQRRSGNTSIVV
 |  . |||      .  | ||. ||. .     |. |.. . . ...   . | |...  | |.. ..      | ..|.    .. ..  |.   .||
arlkcykywPerevPmrvGGysvvlldydikePeygvralrlid.letrearvvkqldllsw.PdkvlaPtavglirfvldvkqhielardasevGPlvv

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL-D
|..  .||| .. |  . ... .  | .|| .|.   | .. . ||.| |.. ..| .  |   
hddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
0046846 (Phosphotyrosine protein) phosphatases II 192-314 1.1e-14 50.1 In-house 77-174 (176) alignment 
Range on Protein: 192-314
Range on HMM: 77-174/176.0
TertieiknkmkggsrhkvvQYQITGWEPNGEVTChQAILMILEEMNKTQRRSgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQ
                    ||. ..|. .|  .  ...| .||.... ...     ..||||  .||.....||      ...|  ..|...|.  | |
i...................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreq

KP-GSVQTVEQYKGIFEIVQIYLD
.| |.||| |||. . | .. .|.
RplgavqtpeQyrflyefellllk
0048076 (Phosphotyrosine protein) phosphatases II 195-312 1.1e-14 49.7 In-house 33-142 (145) alignment 
Range on Protein: 195-312
Range on HMM: 33-142/145.0
TIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRsgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVLKSQRIQKPG
 . . .  .. . ....||. ..|. .|. . .. .| .|| ... ...  .  ..||||  |||.....||   .     .| ......|.  | | ||
vlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpg

SVQTVEQYKGIFEIVQIY
.|....|.. ..| ....
avpnpgqlrflyefelel
0049260 (Phosphotyrosine protein) phosphatases II 181-306 1.2e-14 49.8 In-house 38-143 (152) alignment 
Range on Protein: 181-306
Range on HMM: 38-143/152.0
KLLNEELYDLYTERTIEIknkmkggsrhkvvQYQITGWEPNGEVTCHQAILMILEEMNKTqRRSGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVID
  |.|.|.. .      |             ||. . |. .|  . .| .|..|. ..|  ... .  ..||||  |||.....||   .        ..
vmltellelgklkceqyi.............qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvs

VFQVLKSQRIQKPGSVQTVEQYKGIF
......  | ..||.|.. .|.. ..
leeavalvrekRpgavpnpgqlrfly
0041856 (Phosphotyrosine protein) phosphatases II 205-309 2.8e-14 48.6 In-house 74-167 (182) alignment 
Range on Protein: 205-309
Range on HMM: 74-167/182.0
GSRHKVVQYQITGWEPNGEVTcHQAILMILEEMNKtqrrsGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDVFQVLKSQRIQKPGSVQTVEQYKG
   . ..||. ..|. .|  .  . .| ..||...      .  ..||||  |||.....||   . .    | .......|  | ..||.|.| .||  
llerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyff

IFEIV
.  ..
lqlal
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 161-306 3.3e-14 47.6 In-house 92-233 (239) alignment 
Range on Protein: 161-306
Range on HMM: 92-233/239.0
SVIKYWATEATEviFGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRS
 . .||   ...  . .  . | . |..  |  ||. . .  .    . | ||..| |  .|      |.| .  .. |     |    |.|||  |||.
kchqywpdstsk..ycnlrvtlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrt

AMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
  |    . . ..| .  .|.|. .|. | ..|  ||| |||  |.
gaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 161-306 3.4e-14 47.6 In-house 93-234 (239) alignment 
Range on Protein: 161-306
Range on HMM: 93-234/239.0
SVIKYWATEATEviFGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRS
 . .||   ...  . .  . | . |..  |  ||. . .  .    . | ||..| |  .|      |.| .  .. |     |    |.|||  |||.
kchqywpdstsk..ycnlrvtlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrt

AMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
  |    . . ..| .  .|.|. .|. | ..|  ||| |||  |.
gaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_PTPN14_pd Subfamily PTPN14 161-314 9.3e-14 46.1 In-house 134-297 (300) alignment 
Range on Protein: 161-314
Range on HMM: 134-297/300.0
SVIKYWATE---ATEVIFGEYSIKLLNEELYDLYTERTIEIKNkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTS--------I
  .||.  .   . .| ||.. .     |  | .. .....|  .  . . .|.  | | |  .|     .  |  |||..  .|.. ...        .
ksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkh.lpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

VVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
.||||. |||. .   .   |.  ... .||. .||.  | |.   |||. ||| .....  ||.
lvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0048179 (Phosphotyrosine protein) phosphatases II 195-306 2.9e-13 45.3 In-house 48-138 (144) alignment 
Range on Protein: 195-306
Range on HMM: 48-138/144.0
TieiknkmkggsrhkVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrsGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPG
.              ..||. ..|. .|  .  . .| .|| ... ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||
e..............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpg

SVQTVEQYKGIF
.|.. .|.. . 
avpnpgqlrfLl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 164-309 3.1e-13 44.0 In-house 138-279 (290) alignment 
Range on Protein: 164-309
Range on HMM: 138-279/290.0
KYWATEATE-VIFGEYSIKLLNEELYDLYTE-RTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMnktQRRSGntSIVVHCSDTVGRSA
.|.  .. | . |||...   .|.  |  .  .|. ...| . |  ||.  ..|  |  .       |.| .|  .   .. ||   .|||||  .||. 
qyypekeGevltfGeitvlcseeddkdaniikktlsvrdk.dsGkehklkhlkikswpdksvalstlallrtlril...rkasG..pvvvhcsaGiGrtG

MFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
 | |  ... .. ..|  .|. .. .. |  . .|||   ||  . ||.
tfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 163-309 5.6e-13 43.1 In-house 129-275 (439) alignment 
Range on Protein: 163-309
Range on HMM: 129-275/439.0
IKYWATEAtEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRH-KVVQYQITGWePNGEVTCH-QAILMILEEMNKTQRRSGNTSIVVHCSDTVGRS
 ||| ..| ||..|. ...   .     |. | . . |.   . .   |.|.. . | |. .| ..   .|  |  .| .. .     .|||||  |||.
ykywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiaw.pdknvpaqashvldflrainsandkeeygpvvvhcsagvGrt

AMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
    |   .... |.|  .|.  ..|  | |.   ||.. ||  |.. |
Gtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
0051082 (Phosphotyrosine protein) phosphatases II 200-304 1.3e-12 43.1 In-house 57-144 (151) alignment 
Range on Protein: 200-304
Range on HMM: 57-144/151.0
NkmkggsrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKtqrrSGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTV
.       ..|....|..| . |  .. .|.| .||....     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||. 
g.......ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpn

EQYKG
.|.  
qqflf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 167-302 2.1e-12 41.4 In-house 137-270 (301) alignment 
Range on Protein: 167-302
Range on HMM: 137-270/301.0
ATEA-TEVIFGEYSIKLLNEE--LYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEeMNKTqrrSgNTSIVVHCSDTVGRSAMF
...   ..  | ..||. |.|  | .  ..||.|...  .  . . |. || . |  .|    |  .  ..| . |    | .  ||||||. .|||  |
pvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkk...s.ekPivvhcsaGiGrsvaf

CAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQY
 ..    .. ...  |.. . ||  | ..  .|||..| 
igteylareveadptieltealkhlrehrwngvqtnsql
0044763 (Phosphotyrosine protein) phosphatases II 160-311 1e-11 40.3 In-house 64-169 (178) alignment 
Range on Protein: 160-311
Range on HMM: 64-169/178.0
RSVIKYWATEATevifgeysikllneelydlytertieiknkmkggsrhkvVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrSGNTSIVVHCSDTVGR
 . ..|| .||                                        .||. .... .|. .  . .| ..| ... .  . .  ..||||  |||
lkcdpywpeeag.......................................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgR

SAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVEQYKGIFEIVQI
|....||   .      |. .......  | ..|  |.. .|.. . |. ..
sgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr
0049772 (Phosphotyrosine protein) phosphatases II 207-317 2.4e-11 39.4 In-house 177-284 (314) alignment 
Range on Protein: 207-317
Range on HMM: 177-284/314.0
RHKVVQYQITGWEPnGEVTCHQAILMILEEMNKTqrrSGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTVEQ
 . ...|  . ..  |..   . .. .|| ...    . .. ..|||.. .||.. |..||  . ..   || .. ..|.  | . |     |.... ||
erlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleq

YKGIFEIVQIYLDSFM
|  |.|... ||. ..
yefilealleylkflk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 163-303 3.1e-10 34.0 In-house 134-278 (302) alignment 
Range on Protein: 163-303
Range on HMM: 134-278/302.0
IKYWATEATEV-IFGEYSIKLL--NEELYDLY-----TERTIEIKNKMKGGSRHKVVQ-YQITGWEPNGEVTCHQAILMILEEMNktqrrSGNTSIVVHC
 .|....  ..  ||.|..| .  ...| ..      .  |.||||. |    .| |.  . ..|   |     .. | ||   .     |  ....|||
aeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfce.....sykknvlvhc

SDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYK
|  |||.  . |    |. |... | |. ....  |  . |.||. .|  
saGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 164-310 4.7e-10 34.1 In-house 115-256 (290) alignment 
Range on Protein: 164-310
Range on HMM: 115-256/290.0
KYWATEA-TEVIFGEYSIKLLNEELYDLYTERTIEIKnkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTqrrsgNTSIVVHCSDTVGRSAM
||  ... .|. |.  ..|  . |  |   .|....|    ..  ..|  ... ||..      .. .| ... ...      .| ..||| | . |||.
kYvpesvgeelkfkgltvkCkskekeddvetRelvvk..fddeeeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAa

FCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
. |      |   |.| . . .|||. | |.   ... ...  .   . 
laaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 232-309 5.7e-10 33.5 In-house 216-291 (297) alignment 
Range on Protein: 232-309
Range on HMM: 216-291/297.0
MILEEMNKTQRRsgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
. || ..  . |  |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.||.. ....|
lqleslraempr..nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_CG42327_pd Subfamily CG42327 240-312 9.8e-10 32.6 In-house 241-314 (319) alignment 
Range on Protein: 240-312
Range on HMM: 241-314/319.0
TQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
. .|. .  .|||||| |||. .  |.  .|.. ..    .|. |.. | | ..  .|.|.|||. |. ... |
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 202-313 4.4e-09 30.5 In-house 180-287 (305) alignment 
Range on Protein: 202-313
Range on HMM: 180-287/305.0
MKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEemnKTqrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQTVE
  |.. .|| .|    |   |  .  .||| .||   |.  |.    ||||||  .||.         ...  .  .|.   ..|.  | |.  |.|| .
gpgekarkvthyhwidwpdrgvpaadlailelle...ka..rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtda

QYKGIFEIVQIYL
||  . ...  |.
qylfvhqvilnyf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 213-313 4.9e-09 30.0 In-house 186-285 (302) alignment 
Range on Protein: 213-313
Range on HMM: 186-285/302.0
YQITGWEPNGEVTCHQAILMILEEMnKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
| .| |...   .   ..    ...  ..  ... ..|.     .|| ..| ..|....| ...    . ...|| | |.| .|....||  .. .. .|
yvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly

L
.
i
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 168-307 7.3e-09 30.1 In-house 54-198 (199) alignment 
Range on Protein: 168-307
Range on HMM: 54-198/199.0
TEATEVIFGEYSIKLLNEELYDLYTERT-IEIKNKMKGGSRHKVVQYQITGWEPN--GEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFC
||..   .|  |.          ||  . |  .|     |  .. .||.| |  .   .|.    ...   |. |   .  .. ..|||||  | . .| 
tesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfv

AAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
|    .    . ||  |.|.|.| |  |  . | . ....|. |..
aldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 168-307 7.3e-09 30.1 In-house 53-197 (198) alignment 
Range on Protein: 168-307
Range on HMM: 53-197/198.0
TEATEVIFGEYSIKLLNEELYDLYTERT-IEIKNKMKGGSRHKVVQYQITGWEPN--GEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFC
||..   .|  |.          ||  . |  .|     |  .. .||.| |  .   .|.    ...   |. |   .  .. ..|||||  | . .| 
tesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfv

AAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
|    .    . ||  |.|.|.| |  |  . | . ....|. |..
aldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_ptpA1_pd Subfamily ptpA1 172-272 7.6e-09 29.8 In-house 151-255 (418) alignment 
Range on Protein: 172-272
Range on HMM: 151-255/418.0
EVIFGEYSIKLLnEELYDLYTE-RTIEIKNKMKGGSRhKVVQYQITGWePNGEVTCH-QAILMILEEMNKTQR----R-SGNTSIVVHCSDTVGRSAMFC
. .|| ||..|. | . |   |  | .|.  ..| .|  . |||  || |. ..  | | .  .|  . . |         |  |.||||  |||.  ||
nevfgtysvelv.eviqdpereiitrnirltfegetr.ditqyqyegw.pdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfc

AAATTINK
.|   ..|
tavimmkk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 210-313 9e-08 26.5 In-house 173-271 (288) alignment 
Range on Protein: 210-313
Range on HMM: 173-271/288.0
VVQYQITGWEPNGEVTCHQAILMILEEMnktqrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
| .  .  |. .|    ... | .|| .     .| .  ||||.|  |||.. .      ..  . .  . . ..|.. | ..  ..||  ||  .. .|
vkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv

QIYL
  .|
leel
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 194-295 1e-07 26.3 In-house 101-203 (255) alignment 
Range on Protein: 194-295
Range on HMM: 101-203/255.0
RTIEIKNKMK-GGSRHKVVQYQITGWEPNGEVTCHQAILMILeemnKTQRRSgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVL
||.||  ..      |.|  |. .||  .      . || ||    |  | |   |.|||||  .|||| |  |            . .| . .|  ..|
rtleitstlgekkkthtvkhysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylsll

KSQRIQKPGS
.  | .....
eelrskrkra
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 203-312 1.3e-07 25.9 In-house 172-276 (307) alignment 
Range on Protein: 203-312
Range on HMM: 172-276/307.0
KGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrrsgnTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVEQ
 ..||  . ..| . |  .|      . . .|| ..  .       .|||||  ||||    | .   .|  . .   |. ....  | |.. ..||  |
aqksr.tiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaq

YKGIFEIVQIY
|  .  ..  |
ylylhrvlley
subfamily_hpo-7_pd Subfamily hpo-7 193-298 1.8e-07 25.4 In-house 106-212 (263) alignment 
Range on Protein: 193-298
Range on HMM: 106-212/263.0
ERTIEIKNKMK-GGSRHKVVQYQITGWEPNGEVTCHQAILMILeemnKTQRRSgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQV
 .|.|. . ..     |.| .|. .||  . ...  . || ||    |  | |   |.|||||  .|||| |  | .          . .| . .|  ..
lktlellstlgeKkkthtvkhysykgWiekndpelareilnil....kvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsL

LKSQRIQKPGSVQT
|.  | .......|
leelrssrkraiht
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 201-312 7.3e-07 23.1 In-house 181-288 (305) alignment 
Range on Protein: 201-312
Range on HMM: 181-288/305.0
KMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMnktqrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTV
 . |. .  | . | | |   |   |. . | .|  .     |  .  ||||||  .||.    |    ..|   .  .  . ...|. | |.  |.|. 
tysgdqkmsvrhlqwtewpdrgvppckltslellsai.....rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqnd

EQYKGIFEIVQIY
 ||  |  ..  |
vqylfihrvmlny
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 233-309 8e-07 23.0 In-house 189-265 (281) alignment 
Range on Protein: 233-309
Range on HMM: 189-265/281.0
ILEEMNKTQRRSgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEG-VIDVFQVLKSQRIQ-KPGSVQTVEQYKGIFEIV
.|. . | . ||  |  |.|||  ||||  . |   ...  ..   . |. |..   |.  .  ||||..||  |....
mlkilrkirars..tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 232-313 9.3e-07 21.7 In-house 230-309 (346) alignment 
Range on Protein: 232-313
Range on HMM: 230-309/346.0
MILEEMNKTQRRsgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
|| . . . | .  |. . |      ||.  |  |  .||.       ......|. . |.||.|..  || .|. ||  |.
mihqflsekqvq..nagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 189-320 1.5e-06 22.1 In-house 158-283 (312) alignment 
Range on Protein: 189-320
Range on HMM: 158-283/312.0
DLYTERTIEIKNKMKgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrsgntSIVVHCSDTVGRSAMFCAAA---TTINKCKTEGVIDVFQVL
|  | | . .  |   |   |. .|| . |   |     .. | .|  ..| ..      .. |||  |||.  ..      ... . . . | |.| .|
dkithrvlkvvvkat.gqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvll

KSQRIQkpgSVQTVEQYKGIFEIVQIYLDSFMLYS
. .| .   ||... ||   . .|  .| |  || 
rkdrar...svrvfpqyvyalrcvleflyskglyk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 249-302 7.6e-06 20.2 In-house 1-54 (69) alignment 
Range on Protein: 249-302
Range on HMM: 1-54/69.0
IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQY
.|||||   ||.  | |    . . |.| ..|.|  ..  |  .|  |    .|
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneiey