Gene PTPRD-32 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP087_AA protein Get Run
AqueP087_AA_789-1009 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 844-1009 2.4e-90 297.4 In-house 100-265 (287) alignment
Range on Protein: 844-1009
Range on HMM: 100-265/287.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgIILGEYNITLLKENTSNRYIERKFEVKNTN-TGAKQSVTQFQVTNWDSTGEVKNPQTILMI
|||||.||||||||||||||||||| ||||||||...| ..||||||.||.|.... |||||.||||.| .|.||.|.|.|.|||||||.|..|||||..
rnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillv

IEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||| 
ieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtve

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 844-1009 1.3e-86 285.1 In-house 105-270 (290) alignment
Range on Protein: 844-1009
Range on HMM: 105-270/290.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIiLGEYNITLLKENTSNRYIERKFEVKNTNT-GAKQSVTQFQVTNWDSTGEVKNPQTILMI
..|||.|....||.||||....|.. ..|.||||....   .||..|.||.|.| |.|||||.||||.|. ||||||||.|.|||||||.|.||||||..
vdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

IEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||.
ieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvq

0051299 (Phosphotyrosine protein) phosphatases II 785-1008 8e-51 168.6 In-house 3-272 (288) alignment
Range on Protein: 785-1008
Range on HMM: 3-272/288.0
NLIPVRQFGEFVANGHAKGNEGFKNQFMMLDSGESDHTGTAGLTPSNKLLNRFANIVVS-----------------------------------------
. |.|... ..| . .|.|. |....| .| |   |.| .|.| | |.  ||. .|.                                           
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

---RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStSSGIILGEYNITLLKENTSNRYIERKFEVKNT----NTGAKQSVTQFQVTNWDSTGEVKNP
    .||.|. . ||. ||||... |.. | |.||||. .. ...|.. .|||.| . . |. |..||.|.     .| .. ||.|..|||   |   .|
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

QTILMIIEEMYKTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. .| ......| ..  |.  .|||||. |||.. |.|. . ..  ..||..||....|  | |.||.|||.
ellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

0050432 (Phosphotyrosine protein) phosphatases II 794-1008 3.9e-50 166.3 In-house 33-285 (308) alignment
Range on Protein: 794-1008
Range on HMM: 33-285/308.0
EFVANghAKGNEGFKNQFMMLDSGESDHTGTAGLTPSNKLLNRFANIVVS-----------------------------------------RNFWKMIDD
... .  |... ... .|. | |   ... ...| | || .||. .|.                                            .||.|. .
kllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

RNVTAIVMLCQEKENDLEVCYQYWPST--SSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQ
 ||. ||||... ||. | |.||||..  .. .. | . .|||.| . . |. |..|..|...|    ||.|. |||   |   .|. .| ..|.. |..
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl

rkrGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||.
...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

0047943 (Phosphotyrosine protein) phosphatases II 800-1008 6.2e-48 159.0 In-house 7-258 (273) alignment
Range on Protein: 800-1008
Range on HMM: 7-258/273.0
HAKGNEGFKNQFMMLDSGESDHTGTAGLTPSNKLLNRFANIVVSR----------------------------------------NFWKMIDDRNVTAIV
...|. ... .| .| |   ..| ...| | || .||. .|.                                           .||.|. . ||. ||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

MLCQEKENDLEVCYQYWPSTSS--GIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKR-GNT
||... |.. | |.||||..     .. |.. .|||.|.| . |. |..|..|..|| .  ||.|..|.|   |   ... .| .||.. |....  .|.
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

SIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .|||||. |||.. |.|. . ..  ..|| .||....|  | |.||.|||.
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 844-1007 7.4e-48 158.3 In-house 103-268 (305) alignment
Range on Protein: 844-1007
Range on HMM: 103-268/305.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG-IILGEYNITLLKENTSNRYIERKFEVKN-TNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
..||..| .  |. ||||.. .|.. . |.|||| . .    .||....|  |.| . |||||... .  .   ...|.|.|.|.|   | .. . ..| 
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

IIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|... |.|.|  .....||||..|||. .|.|    ....|.|.|.|||.|||  | .... |||
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqt

0036941 (Phosphotyrosine protein) phosphatases II 801-1008 8.2e-48 158.6 In-house 9-263 (297) alignment
Range on Protein: 801-1008
Range on HMM: 9-263/297.0
AKGNEGFKNQFMMLDSGESDHTGTAGLTPSNKLLNRFANIVVSRN----------------------------------------FWKMIDDRNVTAIVM
.... ... .|. |..   . . ...| | |. .||. .|.   .                                        ||.|. . ||| |||
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

LCQEKENDLEVCYQYWPST-SSGIILGEYNITLLKENT--SNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKR-GNT
|... |.. | |.||||..  . .  |.. .|||....  .. |. |..||..|..| .  ||.|..|.|.  |   .|...| .||.. | ...  ...
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

SIVVHCSDTVGRSAIFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTV
 ..||||. ||||. |.|| . ..  .   .|| .|.....|. | |.||.|||.
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl

0046845 (Phosphotyrosine protein) phosphatases II 807-1008 6.2e-47 155.7 In-house 2-260 (284) alignment
Range on Protein: 807-1008
Range on HMM: 2-260/284.0
FKNQFMMLDSGESDH--TGTAGLTPSNKLLNRFANIVVS--------------------------------------------------RNFWKMIDDRN
.. .|..| |   ..  . ...| | |. .||. .|..                                                    .||.|. . |
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNTN-TGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRK-
|. ||||... ||. | |.||||.... ...|.. .|||.|.. . |. |..|..|.. ||    ||.|..|.|   |   .|. .| ..... . ... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTV
 |.  ||||||. |||.. |.|. . ..  ..||   ..||....|  | |.||.|||.
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl

0040438 (Phosphotyrosine protein) phosphatases II 792-1008 9.4e-47 155.2 In-house 5-262 (317) alignment
Range on Protein: 792-1008
Range on HMM: 5-262/317.0
FGEFVANGHAKGNEGFKNQFMMLDSGESDhTGTAGLTPSNKLLNRFANIVVSR--------------------------------------------NFW
. ...   ..... .....|..|.|   | | . .. | || .||. .|.                                               .||
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

KMIDDRNVTAIVMLCQEKENDLEVCYQYWPStSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMY
.|. . .|| ||||....|.. | |.||||.  . .  |.. .|||.| . . .. |..||...... .  ||.|. |.|.  |  ..|...| ..|.. 
rmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

KTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. .. .... ..||||. |||.. |.|| . .. ...|| .||....|  | |.||.||| 
eale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp

0045450 (Phosphotyrosine protein) phosphatases II 786-1008 1.5e-46 154.9 In-house 8-290 (307) alignment
Range on Protein: 786-1008
Range on HMM: 8-290/307.0
LIPVRQFGEFVANGHAKGNEGFKNQFMMLDSGES--DHTGTAGLTPSNKLLNRFANIVVS----------------------------------------
.|.....  .|.  ......|.. .| .| | .    .. ...| | || .||. .|.                                          
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

-------------RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNT-NTGAKQSVTQFQVTNWDS
              .||.|. . .||.||||....|.. | |.||||.... .  |.. .|||.|.. . |. |..||...  ||    ||.|. |.|  
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpd

TGEVKNPQTILMIIEEMYKTQRKR-GNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
.|  ......| .|||. | ...  ... ..||||. |||.. |.|| . .   ..||.   .|.....|  | |.||.||. 
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

0039614 (Phosphotyrosine protein) phosphatases II 791-1008 1.2e-44 148.4 In-house 18-275 (297) alignment
Range on Protein: 791-1008
Range on HMM: 18-275/297.0
QFGEFVANGHAKGNEGFKNQFMMLDSGESDhtGTAGLTPSNKLLNRFANIVVS----------------------------------------------R
 .  ..   .|... .....|..| |   |   . .| | || .||. .|.                                                 
vldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

NFWKMIDDRNVTAIVMLCQEKENDLeVCYQYWPSTSSgiILGEYNITLLKENTSNRYIERKFEVKNtnTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIE
.||.|. . .||.||||....|..   |.||||....    |.. .||||. . . |. |..||.|  .|    ||.||.|.|   |   .....| ..|
dFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefle

EMYKTQRKR-GNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.. . ...  ... ..||||. |||.. |.|| . .. ...|| .||....|  | |.||.||| 
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp

0043336 (Phosphotyrosine protein) phosphatases II 787-1008 3.3e-44 146.8 In-house 2-263 (278) alignment
Range on Protein: 787-1008
Range on HMM: 2-263/278.0
IPVRQFGEFVANGHAKGNEGFKNQFMMLDSGESdHTGTAGLTPSNKLLNRFANIVV--------------------------------------------
|.| .. ..... ..... .....|  |.|     | . .| | || .||. .|.                                             
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPstSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMI
  .||.|. . .|| ||||....|.. . |.||||  .. .  |.. .|||||.. . |. |..||.|. .| .. ||... ..|   |   .....| .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

IEEMYKTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.... . ..   |. ..||||. |||.. |.|. . ..  ..|| .|.....|  | |.||.||| 
lkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 844-1008 5.3e-44 145.1 In-house 99-279 (301) alignment
Range on Protein: 844-1008
Range on HMM: 99-279/301.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKEN-----------------TSNRYIERKFEVKNTNtgAKQSVTQFQVT
..||..| .  ...|||....||.  . |.||||... .    |. ..|| .|.                 ..| ||||||.||...  . ..|.|.|||
vdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvt

NWDSTGEVKNPQTILMIIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|   | |..|.|.|..|... ..|.| |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.| 
dWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTL

subfamily_PTPRD_pd Subfamily PTPRD 845-1007 1.8e-43 144.1 In-house 106-266 (564) alignment
Range on Protein: 845-1007
Range on HMM: 106-266/564.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSsGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIE
.||.|. ..|.. |||| . .|.. . | .|||...     ||. .|| .|.. . |. |.|..|....  .. |.||. |.| ..|  ......| .|.
dFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlir

EMYKTQrKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. ... ....  ||||||  |||. .|..    ... |.|...|..|..|  | |..  |||
kvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 843-1008 1.5e-41 137.2 In-house 88-252 (283) alignment
Range on Protein: 843-1008
Range on HMM: 88-252/283.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgIILGEYNITLLKENTSNRYIERKFEVKNT-NTGAKQSVTQFQVTNWDSTGEVKnPQTILM
 ..||||. |...|||||| . .|.  . | ||||.  | .  ||. .|| || ||| .| ... ...   . ..  .. .|| .| . ||   .   |.
vvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqa.iinslv

IIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 .. .   |..  .. |||||| ..||.|.|.||...... .|| |.|||.|.|  | |... ||| 
kfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtl

Y_phosphatase Protein-tyrosine phosphatase 844-1008 1.9e-41 137.4 Pfam-A 56-223 (235) alignment
Range on Protein: 844-1008
Range on HMM: 56-223/235.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWP-STSSGIILGEYNITLL-KEN-TSNRYIERKFEVKNTNTG-AKQSVTQFQVTNWDSTGEVKNPQTI
  ||.|. ...|..||||....|.. | | |||| ...     |.....|  ||.  ...|. ||.|.|....  .|..|.|...|||   |  ..|. .
edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksl

LMIIEEMYKTQrKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| .|... |.. .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
ldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

Y_phosphatase Protein-tyrosine phosphatase 844-1008 1.9e-41 137.4 In-house 56-223 (235) alignment
Range on Protein: 844-1008
Range on HMM: 56-223/235.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWP-STSSGIILGEYNITLL-KEN-TSNRYIERKFEVKNTNTG-AKQSVTQFQVTNWDSTGEVKNPQTI
  ||.|. ...|..||||....|.. | | |||| ...     |.....|  ||.  ...|. ||.|.|....  .|..|.|...|||   |  ..|. .
edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksl

LMIIEEMYKTQrKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| .|... |.. .  ....|||||. |||...|.|. . ......|. .||.|..|. | |.||.||..
ldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

0045098 (Phosphotyrosine protein) phosphatases II 819-1008 2.4e-41 137.3 In-house 21-258 (278) alignment
Range on Protein: 819-1008
Range on HMM: 21-258/278.0
SDHTGTAGLTPSNKLLNRFANIVV--------------------------------SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStSSGIILG
.  . | .| ..|. .||. .|.                                   .||.|. . ..|.||||....|.. | |.||||. .. .. |
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltyg

EYNITLLKENTSNRYIERKFEVKNT----NTGAKQSVTQFQVTNWDSTGEVKNP--QTILMIIEEMYKTQR------------KRGNTSIVVHCSDTVGR
.. .|||.| . . |. |...| |.    ... .  ||... ..|.  |   .|  . .| ..|.. . ..              ... ..||||  |||
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SAIFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTV
.. ..|| . .  .  ||..|.....|  | |.|| .||. 
tGtlvaaylmlell..eggvdlleavkelrsqRpglavqnl

0042113 (Phosphotyrosine protein) phosphatases II 829-1008 7.1e-41 135.6 In-house 7-229 (245) alignment
Range on Protein: 829-1008
Range on HMM: 7-229/245.0
PSNKLLNRFANIVVS--------------------------------------------RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStSSGII
| || .||. .|.                                               .||.|. . ..|.||||..| |.. . |.||||. .. . 
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.geslt

LGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKT
 |.. .|||.|.. . |. |..||.|. .. .. |.... ..|.  |.  .....| ..|.. | ... .|. ..||||. |||.. |.|| . ..  ..
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek

EGVIDVFQVLKSQRIQKPGSVQTV
|. .......|  | |.||.||| 
elgvsleeavkelrsqRpgavqtp

0040439 (Phosphotyrosine protein) phosphatases II 825-1008 1.7e-40 134.6 In-house 5-232 (249) alignment
Range on Protein: 825-1008
Range on HMM: 5-232/249.0
AGLTPSNKLLNRFANIVVS--------------------------------------------RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStS
 .| | || .||. .|.                                               .||.|. . ..|.||||....|.. | |.||||. .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.g

SGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKR-GNTSIVVHCSDTVGRSAIFCAAATTI
. .  |.. .|||...... |. |..|..|. .| .  |...|.|.|  .|  ......| .||.. | ...   .. ..||||. |||...|.|| . .
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

NKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  ..|. .|.....|  | |.||.||. 
eqlekelgvdleeavkllrsqRpgavqnp

DSPc_SM00195 844-1007 1.8e-40 134.3 In-house 83-247 (263) alignment
Range on Protein: 844-1007
Range on HMM: 83-247/263.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKENTSN-RYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
. ||.|. ...|. ||||..|.||. | |..|||..| .    |.....| .... .  .| |..|......  ...|||.|..||   |  .... .| 
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

IIEEMYKTQRKRgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
......|....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.|||
llravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt

PTPc_SM00194 844-1007 1.8e-40 134.3 In-house 83-247 (263) alignment
Range on Protein: 844-1007
Range on HMM: 83-247/263.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKENTSN-RYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
. ||.|. ...|. ||||..|.||. | |..|||..| .    |.....| .... .  .| |..|......  ...|||.|..||   |  .... .| 
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

IIEEMYKTQRKRgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
......|....  .. ||||||. |||...|... . ..|...|  .|.|...|. | |.||.|||
llravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 845-1007 1.1e-39 131.4 In-house 114-275 (298) alignment
Range on Protein: 845-1007
Range on HMM: 114-275/298.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGiILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIE
.||.|. ......|||| . .| |   . .|||.. .    || ...||....   .| ||..|.....  ...| |...|.| . |. .| ...| ...
dFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

EMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.|||
kvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqt

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 844-1007 2.2e-39 130.4 In-house 103-265 (318) alignment
Range on Protein: 844-1007
Range on HMM: 103-265/318.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
..||.|. ..| . |||| ||.|.  . . .||||  | . .|.  ..| .| ... |. |.|.|..|.. ... | |...|.|  .|  ... ..| ..
eDfWrmvWeqnsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

EEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 .  |.|.| |.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  |||
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt

0037934 (Phosphotyrosine protein) phosphatases II 827-1008 2.2e-37 124.3 In-house 6-228 (243) alignment
Range on Protein: 827-1008
Range on HMM: 6-228/243.0
LTPSNKLLNRFANIV---------------------------------------VSRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPstSSGiILGE
| | |.  ||. .|.                                       .  .||.|. . ..|.||||....|.. | |.||||  ..    |.
llpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.tygd

YNITLLKENTSNRYIERKFEVKNTN-TGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRK-------RGNTSIVVHCSDTVGRSAIFCAAATTI
. .|||.|.. . |. |.....|.. .. .. |.... ..|   |   .|. .| ...|... ...        ..  ..||||  |||.. ..|| . .
ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylml

NKCkteGvIDVFQVLKSQRIQKPG-SVQTV
 ..   | .|.....|  | |.|| .||| 
lll...g.vdleeavkllreqRpgkavqtp

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 844-1008 5.5e-35 115.8 In-house 66-228 (250) alignment
Range on Protein: 844-1008
Range on HMM: 66-228/250.0
RNFWKMIDDRNVTAIVMLCQEKENDLEvCYQYWPSTSSGiILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
 .||.|. ......|||| . ||.. . . ||||   .  . |.  ..||....   |. ||. . ...   .. | |.. ..|   |  .. ...| ..
edfWrmvleeksgtivmLtnLkesekt.yhqywPvekae.kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLell

EEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... ..|.. ||. ..|.||  ||||  |.|  . ... |.| |.|||.|.|  |...|..|.. 
kkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesl

subfamily_PTPRA_pd Subfamily PTPRA 845-1008 2.8e-34 113.5 In-house 116-281 (330) alignment
Range on Protein: 845-1008
Range on HMM: 116-281/330.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgIILGEYNITLLKENTSNRYIERKFEVK----NTNTGAKQSVTQFQVTNWDSTGEVKNPQTIL
.||.|| ... ..|||| . || . | |.||||.  . .  |. .... .|. .. |  ||| |.    .|.  ... |.||  | |   |   .|. .|
dfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGml

MIIEEMYKTQRKRGNtSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 ..... |.... .. .||||||  |||.  |..  . ... |.|...|||...|. | |.|  ||| 
kllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtd

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 844-1010 1.4e-33 111.2 In-house 98-264 (281) alignment
Range on Protein: 844-1010
Range on HMM: 98-264/281.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVkNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
 .||.|. ...|.||||. .| |..   |..|||  .| ...|.. .. ..|.....||||||.. ....| ...|.|.. |.|  .|  .... .|   
vafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefr

EEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVVI
.|..|...|. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   ||||| 
kevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvq

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 845-1007 1e-32 108.5 In-house 106-268 (319) alignment
Range on Protein: 845-1007
Range on HMM: 106-268/319.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgIILGEYNITLLKENTSNRYIERKFEVKNTNTGA-KQSVTQFQVTNWDSTGEVKNPQTILMII
.||.|. ....  .|||.. .|.    . .|||..      |.. .||..|.  . || ||..... ..     .|..|| |.|   .  .. ...| ..
dfWrmvWeeessivvmltklveklkvklkkywpeenf.eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

EEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
... |...|  .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||.
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqr

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 844-1007 1.3e-32 107.9 In-house 101-262 (315) alignment
Range on Protein: 844-1007
Range on HMM: 101-262/315.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPS-TSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTgaKQSVTQFQVTNWDSTGEVKNPQTILMI
 .||.|. . .||.|||. . .|.|   | ||||   .  . .|.....||. ..    . ||. ......  .. ||||| |.|   |  |.  ..| .
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllkl

IEEMyKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
| |. |..... . |..||||  |||. .....   ... | . ..|||...|  | ..|  |||
ikev.kadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt

subfamily_PTPRK_pd Subfamily PTPRK 844-1007 1.7e-31 104.2 In-house 100-262 (314) alignment
Range on Protein: 844-1007
Range on HMM: 100-262/314.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGiiLGEYNITLLKENTSNRYIERKFEVKN--TNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
..||... | | ..|||| . .|.    |..|||  ..    |. ...|.. .. . .. | | |..   .  ... | ||| ..| . .  .. ...| 
kdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk

IIEEMYKTQRKrGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. .. |.| . ..  ||||||   ||. .|.| .. ..  ..|||.|||.. |. | .|.  |.|
lvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvet

subfamily_PTPN12_pd Subfamily PTPN12 844-1007 1.8e-31 104.1 In-house 97-262 (290) alignment
Range on Protein: 844-1007
Range on HMM: 97-262/290.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGII-LGEYNITLLKENTSN-RYIERKFEVKNTntGAKQSVTQFQVTNWDSTGEVKNPQTILM
 .||.||.. ||. .||.|.| |..   | .|||..    .  ||...|| .|.. .  .. | ..|..   .....|.||. |.|   |  ......| 
ddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssakslle

IIEEMYKTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQT
.||.. ..|. . .. .|||||  |||  . .|   . .  |.| .   .|||... . | |..  |||
lielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqt

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 844-1007 1.8e-31 103.8 In-house 100-261 (515) alignment
Range on Protein: 844-1007
Range on HMM: 100-261/515.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPS-TSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTgaKQSVTQFQVTNWDSTGEVKNPQTILMI
 .||... . |||.|.|. . ||.|   | .|||   .  . .|.... |.  ..    | ||..|   .    . ||||. |.|   |  |. ...| .
ddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllkl

IEEMyKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
| |. |... . . ....|||  |||  .....   . . ||  ..|||....  | ..|  |||
ikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqt

subfamily_Ptp69D_pd Subfamily Ptp69D 845-1007 2.4e-31 104.0 In-house 106-271 (307) alignment
Range on Protein: 845-1007
Range on HMM: 106-271/307.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTsSGIILGEYNITLLKENTSNRYIERKFEVKNTN-----TGAKQSVTQFQVTNWDSTGEVKNPQTI
.||.|| . .|| |||| ...| . . | .|||     .  |. ...| .|.. . ||.|...| ...       ... |.|.. |.|. .   . ....
DfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargl

LMIIEEMYKTQRKRgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
| .||.... ...  .. ||||||  ||||.|| | .  ....|.|  .|.|.. |  | |..  || 
lklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs

subfamily_PTPRB_pd Subfamily PTPRB 845-1009 3.2e-31 103.5 In-house 109-272 (293) alignment
Range on Protein: 845-1009
Range on HMM: 109-272/293.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNtnTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIE
.||.|. ......|||| |  |.  . | .|||.... .. |. ..||..|.. . .. |......  . ....|.|.. | |   |  ....|.| ...
dfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvr

EMYKTQ-RKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.. ... ..  .. ||||||  |||. .| |  . ... ..| ..|.| .. . | ..   |||. 
tvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtek

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 844-1007 8.2e-31 102.2 In-house 106-269 (297) alignment
Range on Protein: 844-1007
Range on HMM: 106-269/297.0
RNFWKMIDDRNVTAIVMLCQEKENDLeVCYQYWPSTSSGIiLGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVK--NPQTILM
 .||.|. | .|..|||| ...|.|   | .||. ...   .|.  ..||  .  . .|.|..||.. .. |.. | |.| ..| .  . .  . ...| 
adfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllk

IIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.|.|. |.  .. .. ..|||.  ||| .....    . . | |  .|.|...|  | ..|  |||
lisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqt

subfamily_PTPN3_pd Subfamily PTPN3 843-1008 1.2e-30 101.4 In-house 97-261 (280) alignment
Range on Protein: 843-1008
Range on HMM: 97-261/280.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMI
. .||.|. ..... |||| .  |.    |.||||.|.  . .||..... ||.... |. |.. .|...|  .....|.| ..|   |  .... .| .
atdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflef

IEEMyKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.|.. ...|.  .. .|||||  .||. .. .  |.. .  ..  . . ....  | |.   |||.
verv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 845-1008 1.8e-30 101.0 In-house 105-265 (288) alignment
Range on Protein: 845-1008
Range on HMM: 105-265/288.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKntNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIE
.||... ..... |||| .  |.. . | .|||..      |. ..||..... . ...||....   .. .  .||.| . |  .|  .. . .| ...
dfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellr

EMyKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
 . |.. .     |.||||. |||. .| |. . |.. ..| .|||. ...  | |..  |||.
qv.kvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtl

subfamily_PTPN23_pd Subfamily PTPN23 844-1009 2.7e-30 100.2 In-house 97-267 (288) alignment
Range on Protein: 844-1009
Range on HMM: 97-267/288.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMI
  ||.|. .. .  |||| ...| . . . .|||.        |....|| ...... ..||.....  .. |..||.  |.|.| . |  . |.|.| .
nDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqf

IEE---MYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVV
..|   .|...... .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||.. 
ldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqeke

subfamily_PTPN6_pd Subfamily PTPN6 845-1008 3.4e-30 100.1 In-house 113-283 (306) alignment
Range on Protein: 845-1008
Range on HMM: 113-283/306.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVK-NTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
.||.|. . | . |||. .| |   | |..|||....    |....| ..|.. ..|| |.. |. ... . ...| |.. ..|   |  |.|...|  .
dFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfl

EEMYKTQRKRG---NTSIVVHCSDTVGRSAIFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTV
|.. . |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | ||| 
edvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqte

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 845-1008 4.1e-29 96.7 In-house 106-274 (325) alignment
Range on Protein: 845-1008
Range on HMM: 106-274/325.0
NFWKMIDDRNvTAIVMLCQEKENDLEVCYQYWPST-SSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
..|... | . ...|..  | ... . | .|||   .    .|  .. |   ..   |. |...||... |  .|| |||.  ||  |  | | |.. |.
dlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

EEM---YKTQR--KRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
. .    .. .   .. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.||
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetv

subfamily_PTPRG_pd Subfamily PTPRG 845-1007 6.5e-29 95.6 In-house 106-272 (563) alignment
Range on Protein: 845-1007
Range on HMM: 106-272/563.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQS------VTQFQVTNWDSTGEVKNPQT
 ||.|| ..||. |||. . .|.  . | .|||.    . .|. ..|| .|..   | .|.. .||..  .|..      |.|.. |.|  .|  . .  
dFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp

ILMIIEEMYKTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 |. ..   .... .    ||||||  |||. ....  | ... ..| ...||..||  | |..  |||
vLifvkkssaank.aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 845-1009 2.8e-27 90.9 In-house 119-278 (319) alignment
Range on Protein: 845-1009
Range on HMM: 119-278/319.0
NFWKMIDDRNVTAIVMLCqekendLEVCYQYWPSTSsGIILGEYNITLLKENTSNRYIERKFEVKN-TNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
.||.|| . |...||.|        . | ||||     |  ..... .   . .. |. |..|. . ..   ....|||    |   |  . |  .....
dfWrmiweyncstivllt......kdkcsqywplki.vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlv

EE-MYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|
kkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 843-1007 4.1e-27 89.9 In-house 105-264 (315) alignment
Range on Protein: 843-1007
Range on HMM: 105-264/315.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTssGIILGEYNITLLKENTSNRYIERKFEVknTNTGAKQSVTQFQVTNWDsTGEVKNPQTILMI
 ..||... . ... |||| .  |.. . . .|||     .| |.. .|. .|.  ..|  | . |  .     . | |...| |  . .| .  . || 
vkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsv..vfgdnirevvqlhytswp.dmgvpkytiplmn

IEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.    |  ..   ..||||||. |||.  |..  . ... ..| .|||.....  | .. . ||.
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqv

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 845-1009 4.1e-27 90.4 In-house 83-242 (284) alignment
Range on Protein: 845-1009
Range on HMM: 83-242/284.0
NFWKMIDDRNVTAIVMLCqekendLEVCYQYWPSTSsGIILGEYNITLLKENTSNRYIERKFEVKN-TNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
.||.|| . |...||.|        . | ||||     |  ..... .   . |. |. |..|. . ..   .....||    |   |  . |  .....
dfWrmiweyncstivllt......kdkcsqywplki.vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlv

EE-MYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
.   . |........||||||  |||. .. .  . ... | |  .||.....  | |..  || .|
kkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv

subfamily_PTPRN_pd Subfamily PTPRN 845-1007 1.8e-26 87.5 In-house 115-277 (297) alignment
Range on Protein: 845-1007
Range on HMM: 115-277/297.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIiLGEYNITLLKENT-SNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
.||.|. .. |. ||.|.. .|.... |..||| . | .  . |.. |. |   .. |. | | .|| .|   ..||||    | ..|   .....|   
dfwqmvweqGvvvivnltrleeegvkqckrywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefr

EEMYKTQRKRGnTSIVVHCSDTVGRSAIFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQT
  . |. | |  ..||||||| .||. ....    .|.  |    ||.   |.  | |.|| |.|
rkvnksyrGrs.cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvkt

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 844-1007 2.1e-26 87.6 In-house 87-253 (274) alignment
Range on Protein: 844-1007
Range on HMM: 87-253/274.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEY---NITLLKENTSNRYIERKFEVKNTNTgaKQSVTQFQVTNWDSTGEVKNPQTIL
 .||.||  ..|. |||| . ||.. . | .|.| . .  | ..|   .|.  | .. | |  ||. .|...   ..||. .  |.|  .   ....|.|
adfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantll

MIIEEMYKTQRKRGNT--SIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
 ...|. ...... .   ..|||||  .||  .| |.  .... . |.|.||...    |... | |||
dlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqt

0036282 (Phosphotyrosine protein) phosphatases II 843-1007 2.3e-26 87.9 In-house 27-155 (174) alignment
Range on Protein: 843-1007
Range on HMM: 27-155/174.0
SrnFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPStssgiilgeynitllkentsnryierkfevknTNTGAKQSVTQFQVTNWDSTGEVKNPQtILMI
.  ||.|. . ..|..|||..|||..|. |..|||.                                . .  .... |.. ..|.  |.   .. .| .
a..fwemlkelgittvvmlleekelglykcinywpe................................lredlerlgiqylylpwpDhgvpdlsi.llef

IEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQT
...... . . ..  ..||||  |||.....||   .   . |...|........| |.||.|||
vkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

subfamily_PTPN1_pd Subfamily PTPN1 844-1008 1.6e-25 84.4 In-house 85-257 (290) alignment
Range on Protein: 844-1008
Range on HMM: 85-257/290.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSS--GIILG--EYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTI
  ||.|. ...  |.||| .  |..   |.||||.  .   ..|   .....|..|.... |. |..|..| .|   .....|  | |   |  . |.. 
dhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaf

LMIIEEMYKTQR-KRGNTSIVVHCSDTVGRSAIFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTV
|  . .. ..   ..     |.|||  .|||  || . | .    | .    .|. .||   | .. | .|| 
lkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta

subfamily_PTPN9_pd Subfamily PTPN9 843-1007 2.8e-25 83.9 In-house 98-275 (297) alignment
Range on Protein: 843-1007
Range on HMM: 98-275/297.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWP-STSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
...||.|. ...|  |||  .  |.    | |||| .. | .  |..... .. .... | .|..|.||..|. ...|| ||.. |   |  .. ...| 
vsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslld

IIEEMYKTQR---------KRG---NTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
..|.. ..|          ..|   .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.||
vlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqt

subfamily_PTPN13_pd Subfamily PTPN13 844-1007 2.9e-25 84.1 In-house 91-254 (273) alignment
Range on Protein: 844-1007
Range on HMM: 91-254/273.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSS-GIILGE-YNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
..||.|. ..... |.|. .|||..   | .|||.. .  . . . ....||| .  . .  |...||....|. . |.... ..|   |  .... .| 
kdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellq

IIEEMYKTQRkrGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
.. |. . |.   .. ||||||  .||| .. .  . ..  . .  .|| ..... | |. | |||
fvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqt

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 844-1009 7.8e-24 78.9 In-house 94-264 (287) alignment
Range on Protein: 844-1009
Range on HMM: 94-264/287.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLK-ENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWdsTGEVKNPQ---TI
|.||... .......... .| |.    ||.|||     . .| | ..||. .. .  |  | . . . .|   . | |... .|    .|  |     |
rdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllsw..PdkvlaPtavgli

LMIIEE--MYKTQRK-RGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 ....     . .|.  .   .|||..  .||| |. |  . ... .  | .|| .|.   | .. . ||.||
rfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavv

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 844-1009 3.2e-23 77.1 In-house 78-251 (270) alignment
Range on Protein: 844-1009
Range on HMM: 78-251/270.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG---IILGEYNITLLKENTSNRYIERKFEVKntNTGAKQSVTQFQVTNWDSTGEVKNP----
..||.|| ...||||||. . .|.  . | .|||. .     .  |. ... |.|. .. || .. ...  ..| .. .. |. ..|   | ....    
ksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedssl

--QTILMIIEEMYKTQRKRGN-TSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
  . .| ..... .....  . . ..||||. |||. .. |  ....  .... .|| ....  | ...  ||...
stdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpe

subfamily_CG7180_pd Subfamily CG7180 845-1007 1.4e-22 74.8 In-house 100-275 (296) alignment
Range on Protein: 845-1007
Range on HMM: 100-275/296.0
NFWKMIDDRNVTAIVMLCQEKENDLeVCYQYWPSTSsGIILGEYNITLLKENTSNRYIERKFEVKNT-------NTG---AKQSVTQFQVTNWDSTGEVK
.||... |... |.|.|... .     . .||| .|     ||  . ...|..      |.| .. .       ...    .  |..||.| |..  .| 
efWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvP

NPQTILMIIEEMYKTQRKRG-----NTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
   . |. . .. .. |..      .  .||..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..
lstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven

subfamily_PTPN14_pd Subfamily PTPN14 844-1008 2.2e-22 74.4 In-house 107-282 (300) alignment
Range on Protein: 844-1008
Range on HMM: 107-282/300.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPST---SSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTIL
..||.|. . .|. |||| .|.|.  | ...|.|..    . .  |....|    ..|...| .....|   .. ...|  .| |.|   |  ..... |
qdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgfl

MIIEEMYKTQRKRGNTS--------IVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  .||.   .||  ...        ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||.
syLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl

0051429 (Phosphotyrosine protein) phosphatases II 844-1009 2.4e-22 75.4 In-house 36-212 (272) alignment
Range on Protein: 844-1009
Range on HMM: 36-212/272.0
RNFWKMiDDRNVTAIVMLCQEKENDLEVCYQYWP-----------STSSGIILGEYNITLLKENTSNRYIERKFEVKNT-NTGAKQSVTQFQVTNWDSTG
..||..  . ....||.|..| | . . |..|||           ..   | .| . .|||.| . . || |....... ..|.   |.... |.|   |
adfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhg

EVKNPqtILMIIEEMYKtqrkrgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVID--------VFQVLKSQRIQKPGSVQTVV
  ...  .| ..|.. .      .  ..||||  ..|.....|.   .     | ..|        ......  | | ||.|||  
vpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqtee

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 786-843 2.9e-22 73.9 In-house 1-58 (290) alignment
Range on Protein: 786-843
Range on HMM: 1-58/290.0
LIPVRQFGEFVANGHAKGNEGFKNQFMMLDSGESDHTGTAGLTPSNKLLNRFANIVVS
|||| .||||||||||||||||.|||.|||||||.|| | |||.|||||||||||||.
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvy

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 845-1008 2.2e-21 71.0 In-house 87-245 (267) alignment
Range on Protein: 845-1008
Range on HMM: 87-245/267.0
NFWKMIDDRNVTAIVMLCQEKENDLEvcyQYWPST-SSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKqSVTQFQVTNWDSTGEVKNPQTilMII
.|...| |..|. ||.| .  ....    ..||          .  .    |.  | |    .|.|  |  |.  || .   .|.   . |       ..
dfltvihdqkvpvivlltkvftdnir...lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesah.nvtlyyykkwnintnnkpylk..plf

EEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  . | | . ||  .||.||| ||||  |  . . ... ||||| |.|. |.  | |..| |.| 
gilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtk

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 844-1008 3.9e-21 70.3 In-house 59-225 (237) alignment
Range on Protein: 844-1008
Range on HMM: 59-225/237.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGA-KQSVTQFQVTNWDSTGEVKNPQTILMI
 .||.|. . . . ||||    |.. . |..|||||      | . ..| |..    |  | . . .  |    . . |.| | |   |  ..  ..| .
ddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrf

IEEMYKTQRKRGN-TSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  .. .  ..  . .  ..|||  |||..||    . . ..| . |.|... ..|   ..|  .|| 
rkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtk

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 843-1008 3.6e-20 66.9 In-house 103-267 (301) alignment
Range on Protein: 843-1008
Range on HMM: 103-267/301.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKENT--SNRYIERKFEVKNTNT-GAKQSVTQFQVTNWDSTGEVKNPQT
| .|| |.   .|  ||||.|. |.  |.| .| |..  . . .| ..|.. ....  ... ..|..||...    | ..|| .| ..|   |  |    
sedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshae

ILMIIeEMYktqrKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  .. |.     |. .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||.
lfdlm.elv....kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn

0049260 (Phosphotyrosine protein) phosphatases II 845-1007 4.3e-20 67.4 In-house 24-135 (152) alignment
Range on Protein: 845-1007
Range on HMM: 24-135/152.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWpstssgiilgeynitllkentsnryierkfevkntntgakqsvtQFQVTNWDSTGEVKNPQTILMIIE
.||.|. . ..|.||||... |.. . |.||.                                            |.. ..|.  |  ...| .|....
dfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDhgvpdlsqlllflll

EMYKTqRKRGNTSIVVHCSDTVGRSAIFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQT
 . |  ... .  ..||||  |||.. ..||   .        ........  | ..||.|..
fiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpn

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 842-1008 1e-19 65.6 In-house 63-226 (239) alignment
Range on Protein: 842-1008
Range on HMM: 63-226/239.0
VSRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIilGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
 | .||.|. .     ||||    |   . |.|||| ..|     .  .|| | .    || | | . .     .. | |...| |   |  .   ..| 
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky..cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg

IIEEMYKtQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  .. | .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
lrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts

0041856 (Phosphotyrosine protein) phosphatases II 844-1008 1.1e-19 66.1 In-house 48-157 (182) alignment
Range on Protein: 844-1008
Range on HMM: 48-157/182.0
RNFWKMIDDRNVTAIVMLCqekendlevCYQYWPstssgiilgeynitllkentsnryierkfevkntnTGAKQSVTQFQVTNWDSTGEVKnPQTILMII
 .|..|. ....|.||.|.         ...|||                                   .  .. ..|.. ..|.  |    ....| .|
adflrmlkelgittivnlt.........eelywp...................................ellerlgiqylylpwpDhgvpd.ldelldfi

EEMYKtqrkrGNTSIVVHCSDTVGRSAIFCAAATTINKckteGvIDVFQVLKSQRIQKPGSVQTV
||...      .  ..||||  |||.. ..||   . .    | .......|  | ..||.|.| 
eevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitp

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 842-1008 1.2e-19 65.5 In-house 64-227 (239) alignment
Range on Protein: 842-1008
Range on HMM: 64-227/239.0
VSRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIilGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILM
 | .||.|. .     ||||    |   . |.|||| ..|     .  .|| | .    || | | . .     .. | |...| |   |  .   ..| 
ssgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky..cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg

IIEEMYKtQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
.  .. | .   |    |.|||  |||.  |    . . ..| .  .|.|. .|. | ..|  ||| 
lrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqts

PTPc_DSPc_SM00012 919-1007 4.7e-19 63.9 In-house 2-92 (105) alignment
Range on Protein: 919-1007
Range on HMM: 2-92/105.0
VTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKRG-NTSIVVHCSDTVGRSAIFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQT
|.....|.|  .|  .... || ..... | ..|.. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.|||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqt

0043147 (Phosphotyrosine protein) phosphatases II 845-1007 9.1e-19 63.3 In-house 35-146 (172) alignment
Range on Protein: 845-1007
Range on HMM: 35-146/172.0
NFWKMIDDRNVTAIVMLCQEkendlevcyqywpstssgiilgeynitllkentsnryierkfevKNTNTGAKQSVTQFQVTNWDSTGEVkNPQTILMIIE
 ||.|. ....|.||.|...                                             .. .. .... |.. ..|.  |   ... .| ..|
dfwrmlkelgithivnltel............................................lydpellerlgiqylylpwpDhgvp.llelllefle

EMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQT
 ... . .. .  ..||||  |||.. ..||   .        . .......  | ..||.||.
fidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqn

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 844-1007 9.8e-19 62.1 In-house 108-268 (290) alignment
Range on Protein: 844-1007
Range on HMM: 108-268/290.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG-IILGEYNITLLKENTS-NRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGeVknPQTILM
 ..|.|. . .|.||||||.  |.    | ||.| ..   . .||. ..  .|..  .. | . . |.. ..| .  .  ...  |     |  ... | 
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks.v..alstla

IIEEMYKTQRKRGntSIVVHCSDTVGRSAIFCAAATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQT
..  ..  ..  |   .|||||  .||.  | |  ... .. ..|  .|. .. .. |  . .||| 
llrtlrilrkasG..pvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqv

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 786-844 2e-18 61.4 In-house 1-60 (287) alignment
Range on Protein: 786-844
Range on HMM: 1-60/287.0
LIPVRQFGEFVANGHAKGNEGFKNQFMMLDS-GESDHTGTAGLTPSNKLLNRFANIVVSR
||||..||||||.|||||||||||||..|.. .....  | .....|| .||...|.|  
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpd

0046846 (Phosphotyrosine protein) phosphatases II 844-1007 2e-18 62.2 In-house 37-158 (176) alignment
Range on Protein: 844-1007
Range on HMM: 37-158/176.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIIlgeynitllkentsnryierkfevkntntgakqsvtQFQVTNWDSTGEVKNpQTILMII
 .|..|. . ..||.|.|..|.| .   |..|||   .  |                                    |.....|.  |     . .| ..
adflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................................qylhlpwpDhgvpdl.elllell

EEMYKTQRKRgnTSIVVHCSDTVGRSAIFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQT
|.... ...     ..||||  .||.. ..||      ...|  ..|...|.  | |.| |.|||
efirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

0051082 (Phosphotyrosine protein) phosphatases II 843-1009 3.4e-17 57.9 In-house 22-140 (151) alignment
Range on Protein: 843-1009
Range on HMM: 22-140/151.0
SRNFWKMIDDRNVTAIVMLCQEKENDleVCYQYWPSTSsgiilgeynitllkentsnryierkfevkntntgakQSVTQFQVTNWDSTGEVKNPQTILMI
.  |.... . ....||.|..|.|..   |..|.|...                                      |.......|. .|   .....| .
ladflellkelgiktivnlrseeerg..ycpeylpelg....................................ievlhipildwpdpglplsfdavlef

IEEMYKtqrkRGNTSIVVHCSDTVGRSAIFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVV
.|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||.  
lellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 838-1007 9.1e-17 55.5 In-house 96-221 (392) alignment
Range on Protein: 838-1007
Range on HMM: 96-221/392.0
ANIVVSRNFWKMIDDRNVTAIVMLCQEKENDlevcyqywpstssgiilgeynitllkentsnryierkfevkntNTGAKQSVTQFQVTNWDSTGEVKNPQ
 |.    .||.|. . |||.|.|. . || |                                           .   ...|.||..|.|   .  |   
pnaaslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhts

TILMIIEEMyKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
..| .|.|. |..  .    ...|||  |||...  .  . . ..|.  ..|||...   | ..|  |||
sllkfikev.kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqt

0044763 (Phosphotyrosine protein) phosphatases II 844-1006 3.3e-16 54.9 In-house 38-155 (178) alignment
Range on Protein: 844-1006
Range on HMM: 38-155/178.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSgiilgeynitllkentsnryierkfevkntntgakqsvTQFQVTNWDSTGEVKNPQTILMII
 ...... . ..|.||.|..|.|.  . |..|||.  .                                       |.. ....  |.   .. .| ..
addlellkelgithivnlteelelgflkcdpywpeeag......................................iqylhipipDhgvpdllehflefv

EEMYKTQRkRGNTSIVVHCSDTVGRSAIFCAAATTINKckTEGVIDVFQVLKSQRiqkPgSVQ
| . . .  . .  ..||||  ||||. ..||   .       . .... ....|   |  |.
efieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl..glsleeaielvrerR...p.ivp

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 824-979 4.8e-15 50.3 In-house 22-172 (255) alignment
Range on Protein: 824-979
Range on HMM: 22-172/255.0
TAGLTPSNKLLNRFANIVVSRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG-IILGEYNITLLKenTSNRYIERKFEVKNTNT--GAKQSVT
| .. |...  ..  ...   .|...|   . . .||||  .|.. | | .|.|    .  .| . |.|  |  .|.  . |  |.  | .     . |.
tehvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvk

QFQVTNWDSTGEVKNPQTILMIIeemyKTQRKRgnTSIVVHCSDTVGRSAIFCAAATTI
 .. . |      .... || |.    |  |.    |.|||||  .|||| |  |    
hysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvy

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 844-1009 5.6e-15 49.7 In-house 105-266 (439) alignment
Range on Protein: 844-1009
Range on HMM: 105-266/439.0
RNFWKMIDDRNVTAIVMLCQEKEndlevCYQYWPSTsSGIILGEYNITLLKENTSNRYIERKFEVKNTNTG--AKQSVTQFQVTNWDSTGEVKNPQTILM
 .||... ..... ||||..  |      |.||||  . .. |.  .   ..    .|. | | | |       ...| ||. . |       .   .| 
ddfwrlviekktvtivmltnlve.....sykywpsd.aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

IIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVV
 .  .  .. |.    .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||...
flrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalc

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 845-999 8.9e-15 49.6 In-house 82-236 (290) alignment
Range on Protein: 845-999
Range on HMM: 82-236/290.0
NFWKMIDDRNVTAIVMLCQEKENDLE----VCYQYWPSTSSG-IILGEYNITLLKENTSNRYIERKFEVKNtNTGAKQSVTQFQVTNWDSTGEVKNPQTI
.|| |. . .|. .||||. .|.. .     | .| | .  . . ..  ..   .  . .  ..|. .||  . . .  ||  .. .|...   ....|.
kfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktl

LMIIEEMYKTqrkrgNTSIVVHCSDTVGRSAIFCAAATTINKCK-TEGVIDVFQVLKSQRI
| .|. . .      .| ..||| | . |||.. |      |   |.| . . .|||. | 
lsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 844-1007 2.8e-14 47.3 In-house 105-273 (302) alignment
Range on Protein: 844-1007
Range on HMM: 105-273/302.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGI-ILGEYNITLLKENTS-NRYIER------KFEVKNTN--TGAKQSVTQFQVTNWDSTGEV
  .| .|.. ||. .| ||. .|.. . | .|.     |   .|.| .. .. .|  ... ..      . |.||..  .  |..|  .. . |   |  
ekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGap

KNPQTILMIIE--EMYKtqrkrgnTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
|...| | |.   | ||       ....||||  |||.  . |    |. |... | |. ....  |  . |.||.
keaytaldilkfcesyk.......knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqd

fn3 Fibronectin type III domain 397-468 8.3e-14 44.7 Pfam-A 11-84 (85) alignment
Range on Protein: 397-468
Range on HMM: 11-84/85.0
KNPDAINIVWNPPTIPNGIITVYEIRYRESTSTG-SYTITNTTDT-IYSIVGLIPNTSYTIGVRAYTSIGPGEW
 ... ... |.||. ..| || ||..|||..... . ..|.. .|  . . || |.|.|.. |.|..  | |..
vtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 844-1008 9.8e-14 45.7 In-house 95-255 (281) alignment
Range on Protein: 844-1008
Range on HMM: 95-255/281.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERkFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMII
 .||.|| . | ||||||||  | . | | .|.|  .   .  .      .. | |. .     .. .  |  . .|..   .|      .  . .| |.
adfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvt.trlnlsyegetrlithwlwkewpdwqvpessevmlkil

eemyKTQRKRgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEG-VIDVFQVLKSQRIQ-KPGSVQTV
    .  | |  |  |.|||  ||||  . |   ...  ..   . |. |..   |.  .  ||||.
....rkirar.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtl

0049772 (Phosphotyrosine protein) phosphatases II 826-999 1.3e-13 46.8 In-house 41-255 (314) alignment
Range on Protein: 826-999
Range on HMM: 41-255/314.0
GLTPSNKLLNRFANIV-------------------------------------------------VSRNFWKMI--DDRNVTAIVM--------------
.  . |.  ||. .|.                                                 .  |.|.|.  .|.||  |||              
adlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCQEKENDlevcyqywpstssGIIlGEYNITLLKentsnryierkfEVKNTNTGAKQSVTQFQVTNWDStGEVKNPQTILMIIEEMYKTqrkR
       |..  .|              ..   . .. |||            |. . .   .. . ..  ....  |..  .. .. ..| . .    .
aAlgKtpllildgng.............nep.taadlellk............eelydpelferlgikylripvpD.gsaplledfdeflefieea...d

GNTSIVVHCSDTVGRSAIFCAAATTINKCKTeGVIDVFQVLKSQRI
 .. ..|||.. .||.. |..||  . ...   . .... ....| 
kggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp

I-set Immunoglobulin I-set domain 678-764 1.9e-13 42.0 Pfam-A 1-90 (90) alignment
Range on Protein: 678-764
Range on HMM: 1-90/90.0
PVIEEFPSNMTTEEGCQVLLKVKVKDTSKPSFNWYHNGDLVTDDYAHELRGDG---SLLLVSVEEKHKGTYRFVANNDAGTVSQQVVLTV
|.... .......|| .| |...|. . .||..|...|  .. .  .... ..   .| . .||.. .|.|. .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

subfamily_hpo-7_pd Subfamily hpo-7 844-979 1.9e-13 44.9 In-house 48-178 (263) alignment
Range on Protein: 844-979
Range on HMM: 48-178/263.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG-IILGEYNITLLkeNTSNRYIERKFEVKNTN--TGAKQSVTQFQVTNWDSTGEVKNPQTIL
 .|...|   . . .||||  .|.. | | .|.|    .  .| . |..    .. .  . .  |. .|       . |.... . |  . ...... ||
dkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvctt..kvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

MIIeemyKTQRKRgnTSIVVHCSDTVGRSAIFCAAATTI
 |.    |  |.    |.|||||  .|||| |  | .  
nil....kvarns..kslvvhcstGiGrsaafsvaElvy

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 845-1007 2.8e-13 44.5 In-house 90-255 (285) alignment
Range on Protein: 845-1007
Range on HMM: 90-255/285.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGI-ILGEYNITL--LKENTSNRYIERKFEVKNTNTGAKQS--VTQFQVTNWDSTGEvknPQTI
.||.|| . ... ..|||   |  .| |  |.|     .  .|.|.|||   ||..    |   . | ||.  . .   . . ||  |        |.  
dfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqla...peda

LMIIeEMYKTQRKR--GNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQT
  .| |.||  .|    .. |.||||  |||.| |     .  .   .  |.......  |  .  .||.
rpmi.elykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqs

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 844-1007 3.5e-13 44.2 In-house 96-262 (307) alignment
Range on Protein: 844-1007
Range on HMM: 96-262/307.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSS-GIILGEYNITLLKENTSNRYIERKFEVKN------TNTGAKQSVTQFQVTNWDSTGevkNP
 .|| |. . .| ...|||.  |     | ||||       . || . |.  .|   . .    .. |        ..  ......| .||   |    |
ysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrg...vp

QTILMIIEEMYKTQRKrgNTSIVVHCSDTVGRSAIFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQT
|. |  |. .  .. .  .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..||
qinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqt

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 844-1008 8e-13 43.0 In-house 96-257 (288) alignment
Range on Protein: 844-1008
Range on HMM: 96-257/288.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTsnRYIERKFE---VKNTNTGAKQS-VTQFQVTNWDSTGEVKNPQTI
 ..|||. . .|  |||||.  |  .|   .|.||     .    . |  |..     |..  .   ......| ..  | .  . .||  |  .| .. 
eelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsp

LMIIEEMyktqrKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| ..| .     |  .  ||||.|  |||.. .      ..  . .  . . ..|.. | ..  ..|| 
lrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqte

fn3 Fibronectin type III domain 294-374 2.9e-12 39.8 Pfam-A 5-83 (85) alignment
Range on Protein: 294-374
Range on HMM: 5-83/85.0
DIILSSVESVSMTVSWDEVPcnGRKGPITGYYLTYTNITSNT-SYTVNITGGDNrMYNLRGLIPYTNYTVSIIPYNYNMNGP
.. .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|.|| |.|.|....  .| . .||
nlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegp

0048076 (Phosphotyrosine protein) phosphatases II 875-1008 3.1e-12 41.9 In-house 2-129 (145) alignment
Range on Protein: 875-1008
Range on HMM: 2-129/145.0
YWPST-SSGIILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKrgNTSIVVHCSDTVGRSAIFC
||||    |. || .  .|  |.  .  | . . . .. .. .. ..|.. ..|.  |.   ....| ..| . . ...  .  ..||||  |||.. ..
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv

AAATTINkcktEGvIDVFQVLKSQRIQKPGSVQTV
||   .     .| ......|.  | | ||.|...
aaylmll....lg.vsleealelvrsqrpgavpnp

subfamily_CG42327_pd Subfamily CG42327 843-947 3.9e-12 40.5 In-house 85-191 (319) alignment
Range on Protein: 843-947
Range on HMM: 85-191/319.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG---IILGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVtNWDSTGEVKNPQTI
| .||... ...   || |..  |. ..|| .|.|.  ..      |.. .|| . .. .||.   . .|. .    . .| .   .|  ..   .....
ssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaal

LMIIEEMY
. .. |. 
iamllevr

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 845-1009 6.8e-12 39.6 In-house 111-276 (305) alignment
Range on Protein: 845-1009
Range on HMM: 111-276/305.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGiILgEYNITLLKENTS-NRYIERKFEVKNTN------TGAKQSVTQFQVTNWDSTGEvknPQ
.|| |. ...|  |||||.  |     | |||| .     | | .  .. || | .. .||  |.. |        . | || ..| |.|   |    | 
efwwmviqnkveqivmlcktvelgklkcaqywpaaqge.kl.elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv...pp

TILMIIEEMYKTqRkRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVV
  |  .| .    |   .  ||||||  .||.    |    ..|   .  .  . ...|. | |.  |.|. |
ckltslellsai.r.gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 844-1005 2.2e-11 38.3 In-house 18-186 (198) alignment
Range on Protein: 844-1005
Range on HMM: 18-186/198.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGI-ILGEYNITLLKENTSNRYIERKFEVKNTNT--GAKQSVTQFQVTNWD--STGEVKNPQT
 .||.|. .     |||. ... |       |||.| ||    |  ..|     |   |    . . |  |   . . ....| | |   .| .|     
adfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvg

ILMIIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSV
...   |. |   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | .
fvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgii

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 844-1005 2.3e-11 38.2 In-house 19-187 (199) alignment
Range on Protein: 844-1005
Range on HMM: 19-187/199.0
RNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGI-ILGEYNITLLKENTSNRYIERKFEVKNTNT--GAKQSVTQFQVTNWD--STGEVKNPQT
 .||.|. .     |||. ... |       |||.| ||    |  ..|     |   |    . . |  |   . . ....| | |   .| .|     
adfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvg

ILMIIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSV
...   |. |   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | .
fvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgii

0048179 (Phosphotyrosine protein) phosphatases II 849-1008 2.4e-11 39.1 In-house 24-131 (144) alignment
Range on Protein: 849-1008
Range on HMM: 24-131/144.0
MIDDRNVTAIVMLCQEKENDLEVCYqywpstssgiilgeynitllkentsnryierkfevkntntgakqsVTQFQVTNWDSTGEVKNPQTILMIIEEMYK
.. . ..|... |. | |.. . ..                                             ..|.. ..|.  |    .. .| ..| . .
llkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefiee

TQRkrGNTSIVVHCSDTVGRSAIFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTV
 ..   .  ..||||  |||.. ..||   .    ..| ......|.  | . ||.|.. 
ale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnp

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 917-1008 5.5e-11 36.5 In-house 89-180 (440) alignment
Range on Protein: 917-1008
Range on HMM: 89-180/440.0
QSVTQFQVTNWDSTGEVKNPQTILMIIEEMYKTQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
... |..   |   |  |    .| .|... ..| | ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| 
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp

subfamily_ptpA1_pd Subfamily ptpA1 845-982 3.2e-10 34.3 In-house 104-256 (418) alignment
Range on Protein: 845-982
Range on HMM: 104-256/418.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSG----------IILGEYNITLLKENT-SNRY-IERkfEVKNTNTGAKQSVTQFQVTNWDSTGE
.||.|. .  .  |||| .| ||    | .|||    |           ..| |.. |..     .|  | |  ... |  |  . .||.|   |     
dfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitr..nirltfegetrditqyqyegwpdhni

VKNPQTILMIIEEMYKTQRK-----RGNTSIVVHCSDTVGRSAIFCAAATTINKC
    | .  ..  . . | .       |  |.||||  |||.  ||.|   ..| 
pdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl

subfamily_egg_pd Subfamily egg 844-1010 7.3e-10 33.0 In-house 97-258 (307) alignment
Range on Protein: 844-1010
Range on HMM: 97-258/307.0
RNFWKMIDDRNVTAIVMLCQEKENdlEVCYQYWPSTSS-GII--LGEYNITLLKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQTIL
 .||.|.   .|  ||||   ||.  | |  ||| . |  ..   | ..|. || .     . |  ..|   .  ..   .    ... ...|  |  .|
ddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvl

MIIEEMyktqrkrgNTSIVVHCSDTVGRSAIFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVVI
  . ..         . .||.. . | ..| . |. ... .    | |  . ||..    | ... ||..|. 
rklrnl........skpvvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvll

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 845-1007 4.1e-09 30.6 In-house 103-272 (305) alignment
Range on Protein: 845-1007
Range on HMM: 103-272/305.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIIL---GEYNITLLKENTSNRYIER--KFEVKNTN------TGAKQSVTQFQVTNWDSTGev
.|| |  . .| || |||. .|   . |..|..|    ..    ..  |..  | ...  ...  | .|..|        . .. ||..   .|   |  
dfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg..

kNPQTILMIIEEMYKTQRKRGntSIVVHCSDTVGRSAIFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQT
  | . | |.| . |..  .|   ||||||  .||.         ...  .  .|.   ..|.  | |.  |.||
.vpaadlailellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqt

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 845-1011 1.2e-08 28.9 In-house 109-279 (310) alignment
Range on Protein: 845-1011
Range on HMM: 109-279/310.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIE---RKFEVKNT---NTGAKQSVTQFQVTNWDSTGEVKNPQT
.||.|| .    .|..||.  |.    |  ||||       |   .| | | . .  |      |   |    .  |.    . .. .|    .   |. 
dfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde

ILMIIEEMYKTQRKRGNtsIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVVIH
    . .   .| . |    |||||  ..|  . .|   .|.| .    .|. .|    . ..   .|| . .
kchtvpqrllaqvrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqy

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 840-939 3.9e-08 27.2 In-house 147-242 (244) alignment
Range on Protein: 840-939
Range on HMM: 147-242/244.0
IVVSRNFWKMIDDRNVTAIVMLCQEKENDlevcyQYWPSTSsGIILGEYNITL-LKENTSNRYI-ERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKNPQ
   | .||||. .| |  .|.|   .|.|     .||| .   .   | .||. | .    . |   ..|..     ..|..| ||..|| | |   |  
adtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdse.plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpndh

TI
 |
fi

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 842-935 1.6e-07 25.7 In-house 40-129 (130) alignment
Range on Protein: 842-935
Range on HMM: 40-129/130.0
VSRNFWKMIDDRNVTAIVMLCQEKENDlevcyQYWPStSSGIILGEYNITLL-KENTSNRYIE-RKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKN
 | .||||. .| |  .|.|   .|.|     .|||  |  .   | .|..   .    ..|.  ..|...    ..|..| ||..|| | |   |
tsmdfwkmmleryvnvlvvlgsveeed.....eywpd.sePlewyeediivtltdrdefknikasnleiesdlneshqaltmfqisnwpsdgttpn

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 844-1008 2.3e-07 24.5 In-house 107-271 (302) alignment
Range on Protein: 844-1008
Range on HMM: 107-271/302.0
RNFWKMIDDRNVTAIVMLCQEKENDLeVCYQYWPSTSSG-IILGEYNITLLKENTSNRYIeRKFEVKNTNTGAKQSVT--QFQVTNWDSTGEVKNPQTIL
 .||.|. ..... .|.| .|.| .     ...| .|      |.  .   | . ..     .. .     |  .||      .||| ..   ..  .. 
eeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeli

MIIEEMYKtQRKRGNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
  ...... .   .. ..|.     .|| ..| ..|....| ...    . ...|| | |.| .|...
ktaakvfa.kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 908-975 2.8e-07 24.6 In-house 207-282 (350) alignment
Range on Protein: 908-975
Range on HMM: 207-282/350.0
VKNTNTGAKQsVTQFQVTNWDSTGEVKNPQTILMIIE---EMY-------KTQRKRGnTSIVVHCSDTVGRSAIFCAA
.. . .     | |.|| ||   . . ||. || ..|   ..          . .|. ..|.||||  |||  .... 
itlaasdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnars.spilvhCsaGvGrtGtlvtl

subfamily_eak_pd Subfamily eak 845-934 3.6e-07 23.9 In-house 108-196 (332) alignment
Range on Protein: 845-934
Range on HMM: 108-196/332.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTS-SGIILGEYNITLLKENTSNRYIERKFEVKNTNTGakQSVTQFQVTNWDSTGEVK
 ||.|. ...  |||.| .. |..||   .|.|  .   .  | ....  .    | .  |..|..  |      |  ..|  |  |   |
afwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnet..hrvlhykvfGwtettlpk

Ig_3 Immunoglobulin domain 677-751 6e-07 21.6 Pfam-A 1-75 (75) alignment
Range on Protein: 677-751
Range on HMM: 1-75/75.0
KPVIEEFPSNMTTEEGCqVLLKVKVKDTS-KPSFNWYHNGDLVTDDYAHELRGDGSLLLVSVEEKHKGTYRFVANN
||||   ||...|..|  | |   ..... .|.. ||  .. . .       ....| . || ... |||. ||.|
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvasN

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 845-884 6.1e-07 23.6 In-house 91-130 (297) alignment
Range on Protein: 845-884
Range on HMM: 91-130/297.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGII
.||... ...| .|||... .|.  . |. ||||.  .  
dfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

Ig_2 Immunoglobulin domain 677-764 9.9e-07 20.7 Pfam-A 1-80 (80) alignment
Range on Protein: 677-764
Range on HMM: 1-80/80.0
KPVIEEFPSNmtTEEGCQVLLKVKVKDTSKPSFNWYHNGDLVTDDYAHelrgdgsLLLVSVEEKHKGTYRFVANND-AGTVSQQVVLTV
|||... |..   .||..| |  ....  .|.. ||..|....   .        |.. .|.....|||. .| |.  ...|. | .||
kpvlsapptv..vtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnsegskqsnsvevtv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 845-881 1.1e-06 22.7 In-house 119-155 (350) alignment
Range on Protein: 845-881
Range on HMM: 119-155/350.0
NFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSS
.|.|.|   .|. |..| .. |..|| ||.||.  | 
dfykvillnkvkvilsltsdvelnlekcyrYWqegsy

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 843-1007 2.3e-06 21.5 In-house 95-261 (312) alignment
Range on Protein: 843-1007
Range on HMM: 95-261/312.0
SRNFWKMIDDRNVTAIVMLCQEKENDLEVCYQYWPSTSSGIILGEYNI------TL-LKENTSNRYIERKFEVKNTNTGAKQSVTQFQVTNWDSTGEVKN
. .||..      |.|..||   |.  | | .|     . . | .. .       . .  .. ..   | . |    || .  . ..| . |   |    
cthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds

PQTILMIIEEMYKTQRkrgntSIVVHCSDTVGRSAIFCAAA---TTINKCKTEGVIDVFQVLKSQRIQkpgSVQT
 .| | ..  . | ..      .. |||  |||.  ..      ... . . . | |.| .|. .| .   ||..
cdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrar...svrv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 845-928 3.2e-06 20.7 In-house 251-329 (440) alignment
Range on Protein: 845-928
Range on HMM: 251-329/440.0
NFWKMIDDRNVTAIVMLCQEkeNDlEVCYQYWPSTSSGIILGEYNITLLKENTSNRYIERKFEVKNTNTgaKQSVTQFQVTNWD
.||... | ....|.|| |   ||   |  |||  .  . .| . .     .  ||   | .|.|  .    . . ||.|  | 
dfwrlvhdyristiimlnql..nd.ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykee..vheirqfevqtwp

Filo_glycop Filovirus glycoprotein 894-960 5.1e-06 13.3 Pfam-A 192-260 (364) alignment
Range on Protein: 894-960
Range on HMM: 192-260/364.0
KENTSNRYIERKFEVKNTNTGAKQSVTQFQV--TNWDSTGEVKNPQTILMIIEEMYKTQRKRGNTSIVV
.|.....|.  . | . ...|...| . |.|  |..    . . ||... . |....|...   |  ..
tedstskYatstleyevedfGteeseiLfevdnttyvqlersltPqfLvqlnetikltnkrsnttgkli

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 945-1008 6.5e-06 20.2 In-house 219-281 (297) alignment
Range on Protein: 945-1008
Range on HMM: 219-281/297.0
EMYKTQRKRgNTSIVVHCSDTVGRSAIFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTV
| ....  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.
eslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtl